{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T06:06:22Z","timestamp":1774677982402,"version":"3.50.1"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,1,30]],"date-time":"2021-01-30T00:00:00Z","timestamp":1611964800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,1,30]],"date-time":"2021-01-30T00:00:00Z","timestamp":1611964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Jinan Science & Technology Development Program, China","award":["201602170"],"award-info":[{"award-number":["201602170"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1007\/s11010-021-04055-y","type":"journal-article","created":{"date-parts":[[2021,1,30]],"date-time":"2021-01-30T09:03:12Z","timestamp":1611997392000},"page":"2061-2073","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["MiR-195-5p inhibits proliferation and invasion of nerve cells in Hirschsprung disease by targeting GFRA4"],"prefix":"10.1007","volume":"476","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8845-0094","authenticated-orcid":false,"given":"Gang","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hefeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,30]]},"reference":[{"key":"4055_CR1","doi-asserted-by":"publisher","first-page":"G1","DOI":"10.1152\/ajpgi.00452.2012","volume":"305","author":"JI Lake","year":"2013","unstructured":"Lake JI, Heuckeroth RO (2013) Enteric nervous system development: migration, differentiation, and disease. Am J Physiol Gastrointest Liver Physiol 305:G1\u2013G24","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"4055_CR2","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1203\/00006450-200105000-00001","volume":"49","author":"CE Gariepy","year":"2001","unstructured":"Gariepy CE (2001) Intestinal motility disorders and development of the enteric nervous system. Pediatr Res 49:605\u2013613","journal-title":"Pediatr Res"},{"key":"4055_CR3","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/jhg.2012.54","volume":"57","author":"TC Carter","year":"2012","unstructured":"Carter TC, Kay DM, Browne ML et al (2012) Hirschsprung\u2019s disease and variants in genes that regulate enteric neural crest cell proliferation, migration and differentiation. J Hum Genet 57:485\u2013493","journal-title":"J Hum Genet"},{"key":"4055_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/jmg.2007.053959","volume":"45","author":"J Amiel","year":"2008","unstructured":"Amiel J, Sproat-Emison E, Garcia-Barcelo M et al (2008) Hirschsprung disease, associated syndromes and genetics: a review. J Med Genet 45:1\u201314","journal-title":"J Med Genet"},{"key":"4055_CR5","doi-asserted-by":"publisher","first-page":"262","DOI":"10.7150\/ijms.7287","volume":"11","author":"LL Wang","year":"2014","unstructured":"Wang LL, Gu H, Fan Y et al (2014) Up-regulated FHL1 expression maybe involved in the prognosis of Hirschsprung\u2019s disease. Int J Med Sci 11:262\u2013267","journal-title":"Int J Med Sci"},{"key":"4055_CR6","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1172\/JCI41619","volume":"120","author":"S Jain","year":"2010","unstructured":"Jain S, Knoten A, Hoshi M et al (2010) Organotypic specificity of key RET adaptor-docking sites in the pathogenesis of neurocristopathies and renal malformations in mice. J Clin Invest 120:778\u2013790","journal-title":"J Clin Invest"},{"key":"4055_CR7","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1093\/hmg\/ddh243","volume":"13","author":"VA Cantrell","year":"2004","unstructured":"Cantrell VA, Owens SE, Chandler RL et al (2004) Interactions between Sox10 and EdnrB modulate penetrance and severity of aganglionosis in the Sox10Dom mouse model of Hirschsprung disease. Hum Mol Genet 13:2289\u20132301","journal-title":"Hum Mol Genet"},{"key":"4055_CR8","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/382070a0","volume":"382","author":"MP Sanchez","year":"1996","unstructured":"Sanchez MP, Silos-Santiago I, Frisen J, He B, Lira SA, Barbacid M (1996) Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature 382:70\u201373","journal-title":"Nature"},{"key":"4055_CR9","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1002\/dvdy.21498","volume":"237","author":"JC Corpening","year":"2008","unstructured":"Corpening JC, Cantrell VA, Deal KK, Southard-Smith EM (2008) A Histone2BCerulean BAC transgene identifies differential expression of Phox2b in migrating enteric neural crest derivatives and enteric glia. Dev Dyn 237:1119\u20131132","journal-title":"Dev Dyn"},{"key":"4055_CR10","doi-asserted-by":"publisher","first-page":"6919","DOI":"10.1073\/pnas.0602152103","volume":"103","author":"TA Heanue","year":"2006","unstructured":"Heanue TA, Pachnis V (2006) Expression profiling the developing mammalian enteric nervous system identifies marker and candidate Hirschsprung disease genes. Proc Natl Acad Sci U S A 103:6919\u20136924","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4055_CR11","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/382076a0","volume":"382","author":"MW Moore","year":"1996","unstructured":"Moore MW, Klein RD, Farinas I et al (1996) Renal and neuronal abnormalities in mice lacking GDNF. Nature 382:76\u201379","journal-title":"Nature"},{"key":"4055_CR12","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1126\/science.8493557","volume":"260","author":"LF Lin","year":"1993","unstructured":"Lin LF, Doherty DH, Lile JD, Bektesh S, Collins F (1993) GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260:1130\u20131132","journal-title":"Science"},{"key":"4055_CR13","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/S0896-6273(00)80453-5","volume":"20","author":"J Milbrandt","year":"1998","unstructured":"Milbrandt J, De Sauvage FJ, Fahrner TJ et al (1998) Persephin, a novel neurotrophic factor related to GDNF and neurturin. Neuron 20:245\u2013253","journal-title":"Neuron"},{"key":"4055_CR14","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1111\/j.1460-9568.1997.tb01499.x","volume":"9","author":"P Naveilhan","year":"1997","unstructured":"Naveilhan P, Elshamy WM, Ernfors P (1997) Differential regulation of mRNAs for GDNF and its receptors Ret and GDNFR alpha after sciatic nerve lesion in the mouse. Eur J Neurosci 9:1450\u20131460","journal-title":"Eur J Neurosci"},{"key":"4055_CR15","doi-asserted-by":"publisher","first-page":"3892","DOI":"10.1038\/sj.onc.1210161","volume":"26","author":"J Yang","year":"2007","unstructured":"Yang J, Runeberg-Roos P, Leppanen VM, Saarma M (2007) The mouse soluble GFRalpha4 receptor activates RET independently of its ligand persephin. Oncogene 26:3892\u20133898","journal-title":"Oncogene"},{"key":"4055_CR16","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1101\/gr.155499.113","volume":"23","author":"K Lee","year":"2013","unstructured":"Lee K, Byun K, Hong W et al (2013) Proteome-wide discovery of mislocated proteins in cancer. Genome Res 23:1283\u20131294","journal-title":"Genome Res"},{"key":"4055_CR17","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/ncb0309-228","volume":"11","author":"J Winter","year":"2009","unstructured":"Winter J, Jung S, Keller S, Gregory RI, Diederichs S (2009) Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol 11:228\u2013234","journal-title":"Nat Cell Biol"},{"key":"4055_CR18","doi-asserted-by":"publisher","first-page":"681","DOI":"10.3892\/etm.2016.3970","volume":"13","author":"YL Chen","year":"2017","unstructured":"Chen YL, Xu QP, Guo F, Guan WH (2017) MicroRNA-302d downregulates TGFBR2 expression and promotes hepatocellular carcinoma growth and invasion. Exp Ther Med 13:681\u2013687","journal-title":"Exp Ther Med"},{"key":"4055_CR19","doi-asserted-by":"crossref","first-page":"101042831769167","DOI":"10.1177\/1010428317691674","volume":"39","author":"Y Zhang","year":"2017","unstructured":"Zhang Y, Zhu X, Zhu X et al (2017) MiR-613 suppresses retinoblastoma cell proliferation, invasion, and tumor formation by targeting E2F5. Tumour Biol 39:1010428317691674","journal-title":"Tumour Biol"},{"key":"4055_CR20","doi-asserted-by":"publisher","first-page":"101042831769594","DOI":"10.1177\/1010428317695947","volume":"39","author":"X Ge","year":"2017","unstructured":"Ge X, Gong L (2017) MiR-590-3p suppresses hepatocellular carcinoma growth by targeting TEAD1. Tumour Biol 39:1010428317695947","journal-title":"Tumour Biol"},{"key":"4055_CR21","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.ijbiomac.2018.05.151","volume":"117","author":"Y Jin","year":"2018","unstructured":"Jin Y, Wang M, Hu H, Huang Q, Chen Y, Wang G (2018) Overcoming stemness and chemoresistance in colorectal cancer through miR-195-5p-modulated inhibition of notch signaling. Int J Biol Macromol 117:445\u2013453","journal-title":"Int J Biol Macromol"},{"key":"4055_CR22","doi-asserted-by":"publisher","first-page":"7378148","DOI":"10.1155\/2017\/7378148","volume":"2017","author":"T Wang","year":"2017","unstructured":"Wang T, Ren Y, Liu R et al (2017) miR-195-5p suppresses the proliferation, migration, and invasion of oral squamous cell carcinoma by targeting TRIM14. Biomed Res Int 2017:7378148","journal-title":"Biomed Res Int"},{"key":"4055_CR23","doi-asserted-by":"publisher","first-page":"2580","DOI":"10.3892\/ijo.2016.3459","volume":"48","author":"XW Pan","year":"2016","unstructured":"Pan XW, Chen L, Hong Y et al (2016) EIF3D silencing suppresses renal cell carcinoma tumorigenesis via inducing G2\/M arrest through downregulation of Cyclin B1\/CDK1 signaling. Int J Oncol 48:2580\u20132590","journal-title":"Int J Oncol"},{"key":"4055_CR24","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods (San Diego, CA) 25:402\u2013408","journal-title":"Methods (San Diego, CA)"},{"key":"4055_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-230X-14-123","volume":"14","author":"H Lei","year":"2014","unstructured":"Lei H, Tang J, Li H et al (2014) MiR-195 affects cell migration and cell proliferation by down-regulating DIEXF in Hirschsprung\u2019s disease. BMC Gastroenterol 14:1\u20137","journal-title":"BMC Gastroenterol"},{"key":"4055_CR26","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1093\/carcin\/bgt312","volume":"35","author":"K Wang","year":"2014","unstructured":"Wang K, Demir IE, D\u2019Haese JG et al (2014) The neurotrophic factor neurturin contributes toward an aggressive cancer cell phenotype, neuropathic pain and neuronal plasticity in pancreatic cancer. Carcinogenesis 35:103\u2013113","journal-title":"Carcinogenesis"},{"key":"4055_CR27","doi-asserted-by":"publisher","first-page":"295","DOI":"10.3389\/fnagi.2016.00295","volume":"8","author":"Q Xu","year":"2016","unstructured":"Xu Q, Fan W, Ye SF et al (2016) Cistanche tubulosa protects dopaminergic neurons through regulation of apoptosis and glial cell-derived neurotrophic factor: in vivo and in vitro. Front Aging Neurosci 8:295","journal-title":"Front Aging Neurosci"},{"key":"4055_CR28","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1006\/mcne.2000.0845","volume":"15","author":"M Lindahl","year":"2000","unstructured":"Lindahl M, Timmusk T, Rossi J, Saarma M, Airaksinen MS (2000) Expression and alternative splicing of mouse Gfra4 suggest roles in endocrine cell development. Mol Cell Neurosci 15:522\u2013533","journal-title":"Mol Cell Neurosci"},{"key":"4055_CR29","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/S0079-6123(10)84013-0","volume":"184","author":"SB Rangasamy","year":"2010","unstructured":"Rangasamy SB, Soderstrom K, Bakay RA, Kordower JH (2010) Neurotrophic factor therapy for Parkinson\u2019s disease. Prog Brain Res 184:237\u2013264","journal-title":"Prog Brain Res"},{"key":"4055_CR30","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1111\/j.1365-2826.2012.02348.x","volume":"24","author":"FL Campos","year":"2012","unstructured":"Campos FL, Cristovao AC, Rocha SM, Fonseca CP, Baltazar G (2012) GDNF contributes to oestrogen-mediated protection of midbrain dopaminergic neurones. J Neuroendocrinol 24:1386\u20131397","journal-title":"J Neuroendocrinol"},{"key":"4055_CR31","doi-asserted-by":"publisher","first-page":"9344","DOI":"10.1074\/jbc.M008279200","volume":"276","author":"M Lindahl","year":"2001","unstructured":"Lindahl M, Poteryaev D, Yu L et al (2001) Human glial cell line-derived neurotrophic factor receptor alpha 4 is the receptor for persephin and is predominantly expressed in normal and malignant thyroid medullary cells. J Biol Chem 276:9344\u20139351","journal-title":"J Biol Chem"},{"key":"4055_CR32","doi-asserted-by":"publisher","first-page":"989","DOI":"10.2147\/CMAR.S163335","volume":"10","author":"L Chai","year":"2018","unstructured":"Chai L, Kang XJ, Sun ZZ et al (2018) MiR-497-5p, miR-195-5p and miR-455-3p function as tumor suppressors by targeting hTERT in melanoma A375 cells. Cancer Manag Res 10:989\u20131003","journal-title":"Cancer Manag Res"},{"key":"4055_CR33","doi-asserted-by":"publisher","first-page":"63986","DOI":"10.18632\/oncotarget.19256","volume":"8","author":"S Chen","year":"2017","unstructured":"Chen S, Wang L, Yao X et al (2017) miR-195-5p is critical in REGgamma-mediated regulation of wnt\/beta-catenin pathway in renal cell carcinoma. Oncotarget 8:63986\u201364000","journal-title":"Oncotarget"},{"key":"4055_CR34","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/j.biopha.2018.03.028","volume":"101","author":"C Feng","year":"2018","unstructured":"Feng C, Zhang L, Sun Y et al (2018) GDPD5, a target of miR-195-5p, is associated with metastasis and chemoresistance in colorectal cancer. Biomed Pharmacother 101:945\u2013952","journal-title":"Biomed Pharmacother"},{"key":"4055_CR35","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1186\/s12885-017-3575-z","volume":"17","author":"E Baltruskeviciene","year":"2017","unstructured":"Baltruskeviciene E, Schveigert D, Stankevicius V et al (2017) Down-regulation of miRNA-148a and miRNA-625-3p in colorectal cancer is associated with tumor budding. BMC Cancer 17:607","journal-title":"BMC Cancer"},{"key":"4055_CR36","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s10555-017-9724-7","volume":"37","author":"R Bayraktar","year":"2018","unstructured":"Bayraktar R, Van Roosbroeck K (2018) miR-155 in cancer drug resistance and as target for miRNA-based therapeutics. Cancer Metastasis Rev 37:33\u201344","journal-title":"Cancer Metastasis Rev"},{"key":"4055_CR37","doi-asserted-by":"publisher","first-page":"712","DOI":"10.2174\/1389200218666170518164507","volume":"18","author":"A Blanca","year":"2017","unstructured":"Blanca A, Cheng L, Montironi R et al (2017) Mirna expression in bladder cancer and their potential role in clinical practice. Curr Drug Metab 18:712\u2013722","journal-title":"Curr Drug Metab"},{"key":"4055_CR38","doi-asserted-by":"publisher","first-page":"33825","DOI":"10.1038\/srep33825","volume":"6","author":"F Du","year":"2016","unstructured":"Du F, Yuan P, Zhao ZT et al (2016) A miRNA-based signature predicts development of disease recurrence in HER2 positive breast cancer after adjuvant trastuzumab-based treatment. Sci Rep 6:33825","journal-title":"Sci Rep"},{"key":"4055_CR39","doi-asserted-by":"publisher","first-page":"112170","DOI":"10.18632\/oncotarget.22750","volume":"8","author":"NH Farina","year":"2017","unstructured":"Farina NH, Ramsey JE, Cuke ME et al (2017) Development of a predictive miRNA signature for breast cancer risk among high-risk women. Oncotarget 8:112170\u2013112183","journal-title":"Oncotarget"},{"key":"4055_CR40","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1089\/dna.2017.3821","volume":"36","author":"G Wang","year":"2017","unstructured":"Wang G, Guo F, Wang H et al (2017) Downregulation of microRNA-483-5p promotes cell proliferation and invasion by targeting GFRA4 in Hirschsprung\u2019s disease. DNA Cell Biol 36:930\u2013937","journal-title":"DNA Cell Biol"},{"key":"4055_CR41","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/nrm3838","volume":"15","author":"M Ha","year":"2014","unstructured":"Ha M, Kim VN (2014) Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol 15:509\u2013524","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4055_CR42","first-page":"1","volume":"38","author":"J Amiel","year":"2008","unstructured":"Amiel J et al (2008) Hirschsprung disease, associated syndromes, and genetics: a review. J Med Genet 38:1\u201314","journal-title":"J Med Genet"},{"key":"4055_CR43","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1373\/clinchem.2003.022061","volume":"50","author":"M Garciabarcel\u00f3","year":"2004","unstructured":"Garciabarcel\u00f3 M, Sham MH, Lee WS et al (2004) Highly recurrent RET mutations and novel mutations in genes of the receptor tyrosine kinase and endothelin receptor B pathways in Chinese patients with sporadic Hirschsprung disease. Clin Chem 50:93\u2013100","journal-title":"Clin Chem"},{"key":"4055_CR44","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1055\/s-2003-41270","volume":"13","author":"G Fitze","year":"2003","unstructured":"Fitze G, Cramer JA, Schreiber M, Roesner D, Schackert HK (2003) Within-gene interaction between c.135 G\/A genotypes and RET proto-oncogene germline mutations in HSCR families. Eur J Pediatr Surg 13:152\u2013157","journal-title":"Eur J Pediatr Surg"},{"key":"4055_CR45","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1016\/j.jpedsurg.2006.03.051","volume":"41","author":"JH Kim","year":"2006","unstructured":"Kim JH, Yoon KO, Kim JK et al (2006) Novel mutations of RET gene in Korean patients with sporadic Hirschsprung\u2019s disease. J Pediatr Surg 41:1250\u20131254","journal-title":"J Pediatr Surg"},{"key":"4055_CR46","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1038\/nsmb.1808","volume":"17","author":"S Kj\u00e6r","year":"2010","unstructured":"Kj\u00e6r S, Hanrahan S, Totty N, McDonald NQ (2010) Mammal-restricted elements predispose human RET to folding impairment by HSCR mutations. Nat Struct Mol Biol 17:726\u2013731","journal-title":"Nat Struct Mol Biol"},{"key":"4055_CR47","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1093\/hmg\/4.8.1381","volume":"4","author":"T Atti\u00e9","year":"1995","unstructured":"Atti\u00e9 T, Pelet A, Edery P et al (1995) Diversity of RET proto-oncogene mutations in familial and sporadic Hirschsprung disease. Hum Mol Genet 4:1381\u20131386","journal-title":"Hum Mol Genet"},{"key":"4055_CR48","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.1016\/j.celrep.2014.08.040","volume":"8","author":"KM Goodman","year":"2014","unstructured":"Goodman KM, Kj\u00e6r S, Beuron F et al (2014) RET recognition of GDNF-GFR\u03b11 ligand by a composite binding site promotes membrane-proximal self-association. Cell Rep 8:1894\u20131904","journal-title":"Cell Rep"},{"key":"4055_CR49","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1210\/jc.2010-0771","volume":"95","author":"JG Cockburn","year":"2010","unstructured":"Cockburn JG, Richardson DS, Gujral TS, Mulligan LM (2010) RET-mediated cell adhesion and migration require multiple integrin subunits. J Clin Endocrinol Metab 95:342\u2013346","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-021-04055-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-021-04055-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-021-04055-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T19:08:06Z","timestamp":1674932886000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-021-04055-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,30]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["4055"],"URL":"https:\/\/doi.org\/10.1007\/s11010-021-04055-y","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,30]]},"assertion":[{"value":"8 October 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no competing interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All of the study subjects were required to provide their written informed consent prior to enrollment. The study protocol was reviewed and approved by the Institutional Review Board of Shandong Provincial Hospital Affiliated to Shandong First Medical University.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}