{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:43:14Z","timestamp":1785544994855,"version":"3.56.0"},"reference-count":201,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T00:00:00Z","timestamp":1618617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T00:00:00Z","timestamp":1618617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1007\/s11010-021-04151-z","type":"journal-article","created":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T08:02:31Z","timestamp":1618646551000},"page":"3177-3190","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Melatonin and its mechanism of action in the female reproductive system and related malignancies"],"prefix":"10.1007","volume":"476","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3725-929X","authenticated-orcid":false,"given":"Maryam","family":"Ezzati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kobra","family":"Velaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raziyeh","family":"Kheirjou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,17]]},"reference":[{"issue":"2","key":"4151_CR1","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1111\/j.1600-079X.2005.00304.x","volume":"40","author":"AW Siu","year":"2006","unstructured":"Siu AW et al (2006) Protective effects of melatonin in experimental free radical-related ocular diseases. J Pineal Res 40(2):101\u2013109","journal-title":"J Pineal Res"},{"issue":"1","key":"4151_CR2","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1254\/jphs.13R01SR","volume":"123","author":"G Sarlak","year":"2013","unstructured":"Sarlak G et al (2013) Effects of melatonin on nervous system aging: neurogenesis and neurodegeneration. J Pharmacol Sci 123(1):9\u201324","journal-title":"J Pharmacol Sci"},{"issue":"3","key":"4151_CR3","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.biocel.2005.08.020","volume":"38","author":"R Hardeland","year":"2006","unstructured":"Hardeland R, Pandi-Perumal S, Cardinali DP (2006) Melatonin. Int J Biochem Cell Biol 38(3):313\u2013316","journal-title":"Int J Biochem Cell Biol"},{"issue":"1","key":"4151_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/jog.12177","volume":"40","author":"H Tamura","year":"2014","unstructured":"Tamura H et al (2014) Melatonin and female reproduction. J Obstet Gynaecol Res 40(1):1\u201311","journal-title":"J Obstet Gynaecol Res"},{"issue":"2\u20133","key":"4151_CR5","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.neuchi.2015.03.002","volume":"61","author":"B Claustrat","year":"2015","unstructured":"Claustrat B, Leston J (2015) Melatonin: physiological effects in humans. Neurochirurgie 61(2\u20133):77\u201384","journal-title":"Neurochirurgie"},{"key":"4151_CR6","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.3389\/fmicb.2015.01565","volume":"6","author":"R Hornedo-Ortega","year":"2016","unstructured":"Hornedo-Ortega R et al (2016) Melatonin and other tryptophan metabolites produced by yeasts: implications in cardiovascular and neurodegenerative diseases. Front Microbiol 6:1565","journal-title":"Front Microbiol"},{"issue":"4","key":"4151_CR7","doi-asserted-by":"publisher","first-page":"6597","DOI":"10.3390\/ijms14046597","volume":"14","author":"C Rodriguez","year":"2013","unstructured":"Rodriguez C et al (2013) Mechanisms involved in the pro-apoptotic effect of melatonin in cancer cells. Int J Mol Sci 14(4):6597\u20136613","journal-title":"Int J Mol Sci"},{"issue":"12","key":"4151_CR8","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1517\/14728222.2013.834890","volume":"17","author":"M Bizzarri","year":"2013","unstructured":"Bizzarri M et al (2013) Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: a review. Expert Opin Ther Targets 17(12):1483\u20131496","journal-title":"Expert Opin Ther Targets"},{"issue":"1","key":"4151_CR9","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/j.1600-079X.2006.00407.x","volume":"42","author":"DX Tan","year":"2007","unstructured":"Tan DX et al (2007) One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species? J Pineal Res 42(1):28\u201342","journal-title":"J Pineal Res"},{"issue":"3","key":"4151_CR10","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1111\/j.1600-079X.2008.00580.x","volume":"45","author":"F Peyrot","year":"2008","unstructured":"Peyrot F, Ducrocq C (2008) Potential role of tryptophan derivatives in stress responses characterized by the generation of reactive oxygen and nitrogen species. J Pineal Res 45(3):235\u2013246","journal-title":"J Pineal Res"},{"key":"4151_CR11","first-page":"57","volume":"1","author":"D-X Tan","year":"1993","unstructured":"Tan D-X (1993) Melatonin: a potent, endogenous hydroxyl radical scavenger. Endocr J 1:57\u201360","journal-title":"Endocr J"},{"issue":"3\u20134","key":"4151_CR12","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.yfrne.2004.08.001","volume":"25","author":"MM Macchi","year":"2004","unstructured":"Macchi MM, Bruce JN (2004) Human pineal physiology and functional significance of melatonin. Front Neuroendocrinol 25(3\u20134):177\u2013195","journal-title":"Front Neuroendocrinol"},{"issue":"3","key":"4151_CR13","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1097\/GCO.0b013e32832924ba","volume":"21","author":"EH Ruder","year":"2009","unstructured":"Ruder EH, Hartman TJ, Goldman MB (2009) Impact of oxidative stress on female fertility. Curr Opin Obstet Gynecol 21(3):219","journal-title":"Curr Opin Obstet Gynecol"},{"issue":"4","key":"4151_CR14","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1210\/jcem-64-4-865","volume":"64","author":"A Brzezinski","year":"1987","unstructured":"Brzezinski A et al (1987) Melatonin in human preovulatory follicular fluid. J Clin Endocrinol Metab 64(4):865\u2013867","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"4151_CR15","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1016\/S0015-0282(03)01008-2","volume":"80","author":"Y Nakamura","year":"2003","unstructured":"Nakamura Y et al (2003) Increased endogenous level of melatonin in preovulatory human follicles does not directly influence progesterone production. Fertil Steril 80(4):1012\u20131016","journal-title":"Fertil Steril"},{"issue":"1","key":"4151_CR16","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.fertnstert.2008.05.016","volume":"92","author":"H Tamura","year":"2009","unstructured":"Tamura H et al (2009) Melatonin and the ovary: physiological and pathophysiological implications. Fertil Steril 92(1):328\u2013343","journal-title":"Fertil Steril"},{"issue":"3","key":"4151_CR17","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.biopha.2006.01.002","volume":"60","author":"C Ekmekcioglu","year":"2006","unstructured":"Ekmekcioglu C (2006) Melatonin receptors in humans: biological role and clinical relevance. Biomed Pharmacother 60(3):97\u2013108","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"4151_CR18","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1159\/000084897","volume":"81","author":"MI Masana","year":"2005","unstructured":"Masana MI, Soares JM Jr, Dubocovich ML (2005) 17\u03b2-estradiol modulates hMT1 melatonin receptor function. Neuroendocrinology 81(2):87\u201395","journal-title":"Neuroendocrinology"},{"issue":"1","key":"4151_CR19","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1186\/1477-7827-10-103","volume":"10","author":"RV Sampaio","year":"2012","unstructured":"Sampaio RV et al (2012) MT3 melatonin binding site, MT1 and MT2 melatonin receptors are present in oocyte, but only MT1 is present in bovine blastocyst produced in vitro. Reprod Biol Endocrinol 10(1):103","journal-title":"Reprod Biol Endocrinol"},{"issue":"1","key":"4151_CR20","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/j.1600-079X.2008.00602.x","volume":"46","author":"JT Kang","year":"2009","unstructured":"Kang JT et al (2009) Effects of melatonin on in vitro maturation of porcine oocyte and expression of melatonin receptor RNA in cumulus and granulosa cells. J Pineal Res 46(1):22\u201328","journal-title":"J Pineal Res"},{"issue":"3","key":"4151_CR21","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1111\/jpi.12345","volume":"61","author":"C He","year":"2016","unstructured":"He C et al (2016) Melatonin and its receptor MT1 are involved in the downstream reaction to luteinizing hormone and participate in the regulation of luteinization in different species. J Pineal Res 61(3):279\u2013290","journal-title":"J Pineal Res"},{"issue":"6","key":"4151_CR22","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1517\/13543784.2012.681045","volume":"21","author":"EJ Sanchez-Barcelo","year":"2012","unstructured":"Sanchez-Barcelo EJ et al (2012) Melatonin uses in oncology: breast cancer prevention and reduction of the side effects of chemotherapy and radiation. Expert Opin Investig Drugs 21(6):819\u2013831","journal-title":"Expert Opin Investig Drugs"},{"issue":"24","key":"4151_CR23","doi-asserted-by":"publisher","first-page":"39896","DOI":"10.18632\/oncotarget.16379","volume":"8","author":"Y Li","year":"2017","unstructured":"Li Y et al (2017) Melatonin for the prevention and treatment of cancer. Oncotarget 8(24):39896","journal-title":"Oncotarget"},{"issue":"3","key":"4151_CR24","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/0304-3835(92)90050-6","volume":"64","author":"SM Hill","year":"1992","unstructured":"Hill SM et al (1992) The growth inhibitory action of melatonin on human breast cancer cells is linked to the estrogen response system. Cancer Lett 64(3):249\u2013256","journal-title":"Cancer Lett"},{"issue":"3\u20134","key":"4151_CR25","first-page":"215","volume":"24","author":"GH El-Sokkary","year":"2003","unstructured":"El-Sokkary GH, Reiier RJ, Abdel-Ghaffar SK (2003) Melatonin supplementation restores cellular proliferation and DNA synthesis in the splenic and thymic lymphocytes of old rats. Neuroendocrinol Lett 24(3\u20134):215\u2013223","journal-title":"Neuroendocrinol Lett"},{"issue":"2","key":"4151_CR26","doi-asserted-by":"publisher","first-page":"2410","DOI":"10.3390\/ijms14022410","volume":"14","author":"G Di Bella","year":"2013","unstructured":"Di Bella G et al (2013) Melatonin anticancer effects. Int J Mol Sci 14(2):2410\u20132430","journal-title":"Int J Mol Sci"},{"issue":"3","key":"4151_CR27","doi-asserted-by":"publisher","first-page":"3945","DOI":"10.1002\/jcb.27678","volume":"120","author":"GH El-Sokkary","year":"2019","unstructured":"El-Sokkary GH, Ismail IA, Saber SH (2019) Melatonin inhibits breast cancer cell invasion through modulating DJ-1\/KLF17\/ID-1 signaling pathway. J Cell Biochem 120(3):3945\u20133957","journal-title":"J Cell Biochem"},{"key":"4151_CR28","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.colsurfb.2016.04.042","volume":"145","author":"M Sabzichi","year":"2016","unstructured":"Sabzichi M et al (2016) Sustained release of melatonin: a novel approach in elevating efficacy of tamoxifen in breast cancer treatment. Colloids Surf B 145:64\u201371","journal-title":"Colloids Surf B"},{"issue":"3","key":"4151_CR29","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1095\/biolreprod.108.075655","volume":"81","author":"RJ Reiter","year":"2009","unstructured":"Reiter RJ et al (2009) Melatonin and reproduction revisited. Biol Reprod 81(3):445\u2013456","journal-title":"Biol Reprod"},{"issue":"2","key":"4151_CR30","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1210\/edrv-12-2-151","volume":"12","author":"RJ Reiter","year":"1991","unstructured":"Reiter RJ (1991) Pineal melatonin: cell biology of its synthesis and of its physiological interactions. Endocr Rev 12(2):151\u2013180","journal-title":"Endocr Rev"},{"issue":"4","key":"4151_CR31","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1111\/jpi.12267","volume":"59","author":"LC Manchester","year":"2015","unstructured":"Manchester LC et al (2015) Melatonin: an ancient molecule that makes oxygen metabolically tolerable. J Pineal Res 59(4):403\u2013419","journal-title":"J Pineal Res"},{"issue":"12","key":"4151_CR32","doi-asserted-by":"publisher","first-page":"3786","DOI":"10.3390\/ijms19123786","volume":"19","author":"K Kleszczy\u0144ski","year":"2018","unstructured":"Kleszczy\u0144ski K et al (2018) Melatonin and its metabolites ameliorate UVR-induced mitochondrial oxidative stress in human MNT-1 melanoma cells. Int J Mol Sci 19(12):3786","journal-title":"Int J Mol Sci"},{"issue":"2","key":"4151_CR33","doi-asserted-by":"publisher","first-page":"e12501","DOI":"10.1111\/jpi.12501","volume":"65","author":"C Skobowiat","year":"2018","unstructured":"Skobowiat C et al (2018) Melatonin and its derivatives counteract the ultraviolet B radiation-induced damage in human and porcine skin ex vivo. J Pineal Res 65(2):e12501","journal-title":"J Pineal Res"},{"issue":"1","key":"4151_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-01305-2","volume":"7","author":"Z Janjetovic","year":"2017","unstructured":"Janjetovic Z et al (2017) Melatonin and its metabolites protect human melanocytes against UVB-induced damage: involvement of NRF2-mediated pathways. Sci Rep 7(1):1\u201313","journal-title":"Sci Rep"},{"issue":"4","key":"4151_CR35","doi-asserted-by":"publisher","first-page":"490","DOI":"10.2174\/0929867321666141215095259","volume":"22","author":"H Gurer-Orhan","year":"2015","unstructured":"Gurer-Orhan H, Suzen S (2015) Melatonin, its metabolites and its synthetic analogs as multi-faceted compounds: antioxidant, prooxidant and inhibitor of bioactivation reactions. Curr Med Chem 22(4):490\u2013499","journal-title":"Curr Med Chem"},{"issue":"8","key":"4151_CR36","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1007\/BF01923944","volume":"49","author":"G Benitez-King","year":"1993","unstructured":"Benitez-King G, Anton-Tay F (1993) Calmodulin mediates melatonin cytoskeletal effects. Experientia 49(8):635\u2013641","journal-title":"Experientia"},{"issue":"4","key":"4151_CR37","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/j.jsmc.2010.08.001","volume":"5","author":"ER Dodson","year":"2010","unstructured":"Dodson ER, Zee PC (2010) Therapeutics for circadian rhythm sleep disorders. Sleep Med Clin 5(4):701\u2013715","journal-title":"Sleep Med Clin"},{"issue":"15","key":"4151_CR38","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1056\/NEJM200010123431503","volume":"343","author":"RL Sack","year":"2000","unstructured":"Sack RL et al (2000) Entrainment of free-running circadian rhythms by melatonin in blind people. N Engl J Med 343(15):1070\u20131077","journal-title":"N Engl J Med"},{"issue":"2","key":"4151_CR39","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/0197-0186(92)90166-O","volume":"20","author":"M Djamgoz","year":"1992","unstructured":"Djamgoz M, Wagner H-J (1992) Localization and function of dopamine in the adult vertebrate retina. Neurochem Int 20(2):139\u2013191","journal-title":"Neurochem Int"},{"issue":"9","key":"4151_CR40","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1007\/s10815-011-9604-y","volume":"28","author":"OG Eryilmaz","year":"2011","unstructured":"Eryilmaz OG et al (2011) Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems. J Assist Reprod Genet 28(9):815","journal-title":"J Assist Reprod Genet"},{"issue":"13","key":"4151_CR41","doi-asserted-by":"publisher","first-page":"2813","DOI":"10.1111\/j.1742-4658.2006.05322.x","volume":"273","author":"SR Pandi-Perumal","year":"2006","unstructured":"Pandi-Perumal SR et al (2006) Melatonin: nature\u2019s most versatile biological signal? FEBS J 273(13):2813\u20132838","journal-title":"FEBS J"},{"key":"4151_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1297-9686-37-S1-S39","volume":"37","author":"DR Notter","year":"2005","unstructured":"Notter DR, Cockett NE (2005) Opportunities for detection and use of QTL influencing seasonal reproduction in sheep: a review. Genet Sel Evol 37:1\u201316","journal-title":"Genet Sel Evol"},{"issue":"1\u20134","key":"4151_CR43","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1159\/000075727","volume":"102","author":"L Iannuzzi","year":"2003","unstructured":"Iannuzzi L et al (2003) The river buffalo (Bubalus bubalis, 2n= 50) cytogenetic map: assignment of 64 loci by fluorescence in situ hybridization and R-banding. Cytogenet Genome Res 102(1\u20134):65\u201375","journal-title":"Cytogenet Genome Res"},{"issue":"6","key":"4151_CR44","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1177\/074873049701200606","volume":"12","author":"SM Reppert","year":"1997","unstructured":"Reppert SM (1997) Melatonin receptors: molecular biology of a new family of G protein-coupled receptors. J Biol Rhythms 12(6):528\u2013531","journal-title":"J Biol Rhythms"},{"issue":"20","key":"4151_CR45","doi-asserted-by":"publisher","first-page":"9789","DOI":"10.1158\/0008-5472.CAN-06-1776","volume":"66","author":"B Jung","year":"2006","unstructured":"Jung B, Ahmad N (2006) Melatonin in cancer management: progress and promise. Cancer Res 66(20):9789\u20139793","journal-title":"Cancer Res"},{"key":"4151_CR46","doi-asserted-by":"crossref","unstructured":"Ekmekcioglu C, Thalhammer T (2014) Melatonin receptors and their role in human diseases. In Melatonin and melatonergic drugs in clinical practice. Springer, New Delhi, pp 1\u201315","DOI":"10.1007\/978-81-322-0825-9_1"},{"issue":"2","key":"4151_CR47","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.ejogrb.2012.10.006","volume":"166","author":"CC Maganhin","year":"2013","unstructured":"Maganhin CC et al (2013) Effects of melatonin on ovarian follicles. Eur J Obstet Gynecol Reprod Biol 166(2):178\u2013184","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"1","key":"4151_CR48","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.fertnstert.2014.04.006","volume":"102","author":"CC Maganhin","year":"2014","unstructured":"Maganhin CC et al (2014) Melatonin influences on steroidogenic gene expression in the ovary of pinealectomized rats. Fertil Steril 102(1):291\u2013298","journal-title":"Fertil Steril"},{"issue":"10","key":"4151_CR49","doi-asserted-by":"publisher","first-page":"4789","DOI":"10.1210\/jcem.86.10.7912","volume":"86","author":"MM Woo","year":"2001","unstructured":"Woo MM et al (2001) Direct action of melatonin in human granulosa-luteal cells. J Clin Endocrinol Metab 86(10):4789\u20134797","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"4151_CR50","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.4161\/cc.5.11.2803","volume":"5","author":"M Jamnongjit","year":"2006","unstructured":"Jamnongjit M, Hammes SR (2006) Ovarian steroids: the good, the bad, and the signals that raise them. Cell Cycle 5(11):1178\u20131183","journal-title":"Cell Cycle"},{"issue":"1","key":"4151_CR51","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1002\/mrd.20142","volume":"70","author":"X Jin","year":"2005","unstructured":"Jin X et al (2005) Anti-apoptotic action of stem cell factor on oocytes in primordial follicles and its signal transduction. Mol Reprod Dev Inc Gamete Res 70(1):82\u201390","journal-title":"Mol Reprod Dev Inc Gamete Res"},{"issue":"3","key":"4151_CR52","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1530\/ror.0.0050143","volume":"5","author":"M-A Driancourt","year":"2000","unstructured":"Driancourt M-A et al (2000) Roles of KIT and KIT LIGAND in ovarian function. Rev Reprod 5(3):143\u2013152","journal-title":"Rev Reprod"},{"issue":"11","key":"4151_CR53","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1016\/j.biocel.2006.12.005","volume":"39","author":"CE Edling","year":"2007","unstructured":"Edling CE, Hallberg B (2007) c-Kit\u2014a hematopoietic cell essential receptor tyrosine kinase. Int J Biochem Cell Biol 39(11):1995\u20131998","journal-title":"Int J Biochem Cell Biol"},{"issue":"1","key":"4151_CR54","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1111\/j.1600-079X.2008.00600.x","volume":"46","author":"L Ort\u00edz-L\u00f3pez","year":"2009","unstructured":"Ort\u00edz-L\u00f3pez L et al (2009) ROCK-regulated cytoskeletal dynamics participate in the inhibitory effect of melatonin on cancer cell migration. J Pineal Res 46(1):15\u201321","journal-title":"J Pineal Res"},{"issue":"3","key":"4151_CR55","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/j.1600-079X.2004.00165.x","volume":"37","author":"RJ Reiter","year":"2004","unstructured":"Reiter RJ (2004) Mechanisms of cancer inhibition by melatonin. J Pineal Res 37(3):213\u2013214","journal-title":"J Pineal Res"},{"issue":"21","key":"4151_CR56","doi-asserted-by":"publisher","first-page":"3883","DOI":"10.1007\/s00018-017-2615-9","volume":"74","author":"R Hardeland","year":"2017","unstructured":"Hardeland R (2017) Melatonin and the electron transport chain. Cell Mol Life Sci 74(21):3883\u20133896","journal-title":"Cell Mol Life Sci"},{"issue":"4","key":"4151_CR57","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1111\/j.1600-079X.2007.00513.x","volume":"43","author":"DX Tan","year":"2007","unstructured":"Tan DX et al (2007) Melatonin as a naturally occurring co-substrate of quinone reductase-2, the putative MT3 melatonin membrane receptor: hypothesis and significance. J Pineal Res 43(4):317\u2013320","journal-title":"J Pineal Res"},{"issue":"3","key":"4151_CR58","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1517\/14728222.2016.1091882","volume":"20","author":"JA Boutin","year":"2016","unstructured":"Boutin JA (2016) Quinone reductase 2 as a promising target of melatonin therapeutic actions. Expert Opin Ther Targets 20(3):303\u2013317","journal-title":"Expert Opin Ther Targets"},{"issue":"2\u20133","key":"4151_CR59","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.tox.2006.09.018","volume":"228","author":"I Adriaens","year":"2006","unstructured":"Adriaens I et al (2006) Melatonin has dose-dependent effects on folliculogenesis, oocyte maturation capacity and steroidogenesis. Toxicology 228(2\u20133):333\u2013343","journal-title":"Toxicology"},{"issue":"3","key":"4151_CR60","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.toxlet.2011.01.029","volume":"202","author":"J Wu","year":"2011","unstructured":"Wu J et al (2011) T-2 toxin induces apoptosis in ovarian granulosa cells of rats through reactive oxygen species-mediated mitochondrial pathway. Toxicol Lett 202(3):168\u2013177","journal-title":"Toxicol Lett"},{"issue":"3","key":"4151_CR61","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1111\/jpi.12010","volume":"54","author":"A Galano","year":"2013","unstructured":"Galano A, Tan DX, Reiter RJ (2013) On the free radical scavenging activities of melatonin\u2019s metabolites, AFMK and AMK. J Pineal Res 54(3):245\u2013257","journal-title":"J Pineal Res"},{"issue":"2","key":"4151_CR62","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1111\/j.1600-079X.2011.00878.x","volume":"51","author":"T Taketani","year":"2011","unstructured":"Taketani T et al (2011) Protective role of melatonin in progesterone production by human luteal cells. J Pineal Res 51(2):207\u2013213","journal-title":"J Pineal Res"},{"issue":"1","key":"4151_CR63","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1262\/jrd.2014-105","volume":"61","author":"M Tanabe","year":"2014","unstructured":"Tanabe M et al (2014) Melatonin protects the integrity of granulosa cells by reducing oxidative stress in nuclei, mitochondria, and plasma membranes in mice. J Reprod Dev 61(1):35\u201341","journal-title":"J Reprod Dev"},{"issue":"26","key":"4151_CR64","doi-asserted-by":"publisher","first-page":"16339","DOI":"10.1074\/jbc.273.26.16339","volume":"273","author":"F Arakane","year":"1998","unstructured":"Arakane F et al (1998) The mechanism of action of steroidogenic acute regulatory protein (StAR) StAR acts on the outside of mitochondria to stimulate steroidogenesis. J Biol Chem 273(26):16339\u201316345","journal-title":"J Biol Chem"},{"issue":"1","key":"4151_CR65","first-page":"108","volume":"20","author":"M Ezzati","year":"2018","unstructured":"Ezzati M et al (2018) Evaluating the effect of melatonin on HAS2, and PGR expression, as well as cumulus expansion, and fertility potential in mice. Cell J (Yakhteh) 20(1):108","journal-title":"Cell J (Yakhteh)"},{"issue":"3","key":"4151_CR66","doi-asserted-by":"publisher","first-page":"R183","DOI":"10.1530\/ERC-15-0030","volume":"22","author":"SM Hill","year":"2015","unstructured":"Hill SM et al (2015) Melatonin: an inhibitor of breast cancer. Endocr Relat Cancer 22(3):R183\u2013R204","journal-title":"Endocr Relat Cancer"},{"issue":"3","key":"4151_CR67","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s10911-011-9222-4","volume":"16","author":"SM Hill","year":"2011","unstructured":"Hill SM et al (2011) Melatonin and associated signaling pathways that control normal breast epithelium and breast cancer. J Mammary Gland Biol Neoplasia 16(3):235","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"4151_CR68","doi-asserted-by":"publisher","first-page":"106371","DOI":"10.1016\/j.domaniend.2019.06.003","volume":"72","author":"N Soni","year":"2019","unstructured":"Soni N et al (2019) Expression of MTNR1A, steroid (ER\u03b1, ER\u03b2, and PR) receptor gene transcripts, and the concentration of melatonin and steroid hormones in the ovarian follicles of buffalo. Domest Anim Endocrinol 72:106371","journal-title":"Domest Anim Endocrinol"},{"issue":"2","key":"4151_CR69","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1086\/physzool.23.2.30152069","volume":"23","author":"C Ladd Prosser","year":"1950","unstructured":"Ladd Prosser C, Weinstein SJ (1950) Comparison of blood volume in animals with open and with closed circulatory systems. Physiol Zool 23(2):113\u2013124","journal-title":"Physiol Zool"},{"issue":"7","key":"4151_CR70","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1542\/pir.28.7.249","volume":"28","author":"DS Jardine","year":"2007","unstructured":"Jardine DS (2007) Heat illness and heat stroke. Pediatr Rev 28(7):249","journal-title":"Pediatr Rev"},{"issue":"12","key":"4151_CR71","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.1242\/jeb.040626","volume":"213","author":"AV Sirotkin","year":"2010","unstructured":"Sirotkin AV (2010) Effect of two types of stress (heat shock\/high temperature and malnutrition\/serum deprivation) on porcine ovarian cell functions and their response to hormones. J Exp Biol 213(12):2125\u20132130","journal-title":"J Exp Biol"},{"issue":"2","key":"4151_CR72","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.theriogenology.2008.03.005","volume":"70","author":"Y Yuan","year":"2008","unstructured":"Yuan Y et al (2008) Heat shock at the germinal vesicle breakdown stage induces apoptosis in surrounding cumulus cells and reduces maturation rates of porcine oocytes in vitro. Theriogenology 70(2):168\u2013178","journal-title":"Theriogenology"},{"issue":"1","key":"4151_CR73","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/BF02186927","volume":"8","author":"R Dutt","year":"1964","unstructured":"Dutt R (1964) Detrimental effects of high ambient temperature on fertility and early embryo survival in sheep. Int J Biometeorol 8(1):47\u201356","journal-title":"Int J Biometeorol"},{"issue":"2","key":"4151_CR74","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1095\/biolreprod19.2.306","volume":"19","author":"KK Schillo","year":"1978","unstructured":"Schillo KK, Alliston CW, Malven PV (1978) Plasma concentrations of luteinizing hormone and prolactin in the ovariectomized ewe during induced hyperthermia. Biol Reprod 19(2):306\u2013313","journal-title":"Biol Reprod"},{"issue":"4","key":"4151_CR75","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1530\/rep.1.00502","volume":"129","author":"T Shimizu","year":"2005","unstructured":"Shimizu T et al (2005) Heat stress diminishes gonadotropin receptor expression and enhances susceptibility to apoptosis of rat granulosa cells. Reproduction 129(4):463\u2013472","journal-title":"Reproduction"},{"issue":"6","key":"4151_CR76","doi-asserted-by":"publisher","first-page":"731","DOI":"10.2131\/jts.42.731","volume":"42","author":"M Moniruzzaman","year":"2017","unstructured":"Moniruzzaman M et al (2017) Change in redox state and heat shock protein expression in an Indian major carp Cirrhinus cirrhosus exposed to zinc and lead. J Toxicol Sci 42(6):731\u2013740","journal-title":"J Toxicol Sci"},{"key":"4151_CR77","doi-asserted-by":"crossref","unstructured":"Moniruzzaman M et al (2018) Melatonin ameliorates H2O2-induced oxidative stress through modulation of Erk\/Akt\/NFkB pathway. Biol Res 11;51(1):17","DOI":"10.1186\/s40659-018-0168-5"},{"issue":"3","key":"4151_CR78","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1111\/jpi.12268","volume":"59","author":"Y Li","year":"2015","unstructured":"Li Y et al (2015) Melatonin protects porcine oocyte in vitro maturation from heat stress. J Pineal Res 59(3):365\u2013375","journal-title":"J Pineal Res"},{"issue":"1","key":"4151_CR79","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10561-019-09797-0","volume":"21","author":"M Ezzati","year":"2020","unstructured":"Ezzati M et al (2020) Influence of cryopreservation on structure and function of mammalian spermatozoa: an overview. Cell Tissue Bank 21(1):1\u201315","journal-title":"Cell Tissue Bank"},{"issue":"1","key":"4151_CR80","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s00580-017-2555-7","volume":"27","author":"T Mazoochi","year":"2018","unstructured":"Mazoochi T et al (2018) The effect of melatonin on expression of p53 and ovarian preantral follicle development isolated from vitrified ovary. Comp Clin Pathol 27(1):83\u201388","journal-title":"Comp Clin Pathol"},{"issue":"3","key":"4151_CR81","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.fertnstert.2006.11.177","volume":"88","author":"Y Englert","year":"2007","unstructured":"Englert Y et al (2007) Impaired ovarian stimulation during in vitro fertilization in women who are seropositive for hepatitis C virus and seronegative for human immunodeficiency virus. Fertil Steril 88(3):607\u2013611","journal-title":"Fertil Steril"},{"issue":"1","key":"4151_CR82","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.theriogenology.2006.09.014","volume":"67","author":"M Kuwayama","year":"2007","unstructured":"Kuwayama M (2007) Highly efficient vitrification for cryopreservation of human oocytes and embryos: the Cryotop method. Theriogenology 67(1):73\u201380","journal-title":"Theriogenology"},{"issue":"2","key":"4151_CR83","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.cryobiol.2007.06.008","volume":"55","author":"T Somfai","year":"2007","unstructured":"Somfai T et al (2007) Developmental competence of in vitro-fertilized porcine oocytes after in vitro maturation and solid surface vitrification: effect of cryopreservation on oocyte antioxidative system and cell cycle stage. Cryobiology 55(2):115\u2013126","journal-title":"Cryobiology"},{"issue":"3","key":"4151_CR84","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1111\/j.1600-079X.2009.00663.x","volume":"46","author":"P Maity","year":"2009","unstructured":"Maity P et al (2009) Melatonin reduces indomethacin-induced gastric mucosal cell apoptosis by preventing mitochondrial oxidative stress and the activation of mitochondrial pathway of apoptosis. J Pineal Res 46(3):314\u2013323","journal-title":"J Pineal Res"},{"issue":"2","key":"4151_CR85","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1111\/j.1600-079X.2004.00166.x","volume":"38","author":"AA Juknat","year":"2005","unstructured":"Juknat AA et al (2005) Melatonin prevents hydrogen peroxide-induced Bax expression in cultured rat astrocytes. J Pineal Res 38(2):84\u201392","journal-title":"J Pineal Res"},{"issue":"1","key":"4151_CR86","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.tips.2014.10.011","volume":"36","author":"SD Naidu","year":"2015","unstructured":"Naidu SD, Kostov RV, Dinkova-Kostova AT (2015) Transcription factors Hsf1 and Nrf2 engage in crosstalk for cytoprotection. Trends Pharmacol Sci 36(1):6\u201314","journal-title":"Trends Pharmacol Sci"},{"issue":"7","key":"4151_CR87","doi-asserted-by":"publisher","first-page":"2806","DOI":"10.1210\/en.2011-0207","volume":"152","author":"BN Nakamura","year":"2011","unstructured":"Nakamura BN et al (2011) Lack of maternal glutamate cysteine ligase modifier subunit (Gclm) decreases oocyte glutathione concentrations and disrupts preimplantation development in mice. Endocrinology 152(7):2806\u20132815","journal-title":"Endocrinology"},{"issue":"4","key":"4151_CR88","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1111\/jpi.12090","volume":"55","author":"R Hardeland","year":"2013","unstructured":"Hardeland R (2013) Melatonin and the theories of aging: a critical appraisal of melatonin\u2019s role in antiaging mechanisms. J Pineal Res 55(4):325\u2013356","journal-title":"J Pineal Res"},{"issue":"7","key":"4151_CR89","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1016\/j.theriogenology.2016.05.026","volume":"86","author":"MC Rodrigues-Cunha","year":"2016","unstructured":"Rodrigues-Cunha MC et al (2016) Effects of melatonin during IVM in defined medium on oocyte meiosis, oxidative stress, and subsequent embryo development. Theriogenology 86(7):1685\u20131694","journal-title":"Theriogenology"},{"issue":"3","key":"4151_CR90","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.bbamcr.2011.08.013","volume":"1823","author":"SD Hartson","year":"2012","unstructured":"Hartson SD, Matts RL (2012) Approaches for defining the Hsp90-dependent proteome. Biochimica et Biophysica Acta (BBA)-Mol Cell Res 1823(3):656\u2013667","journal-title":"Biochimica et Biophysica Acta (BBA)-Mol Cell Res"},{"issue":"3","key":"4151_CR91","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s12192-010-0239-1","volume":"16","author":"F Le Masson","year":"2011","unstructured":"Le Masson F, Christians E (2011) HSFs and regulation of Hsp70. 1 (Hspa1b) in oocytes and preimplantation embryos: new insights brought by transgenic and knockout mouse models. Cell Stress Chaperones 16(3):275\u2013285","journal-title":"Cell Stress Chaperones"},{"issue":"1","key":"4151_CR92","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s40104-015-0004-5","volume":"6","author":"Z Zeng","year":"2015","unstructured":"Zeng Z et al (2015) Essential oil and aromatic plants as feed additives in non-ruminant nutrition: a review. J Anim Sci Biotechnol 6(1):7","journal-title":"J Anim Sci Biotechnol"},{"issue":"3","key":"4151_CR93","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.pneurobio.2010.12.004","volume":"93","author":"R Hardeland","year":"2011","unstructured":"Hardeland R et al (2011) Melatonin\u2014a pleiotropic, orchestrating regulator molecule. Prog Neurobiol 93(3):350\u2013384","journal-title":"Prog Neurobiol"},{"issue":"3","key":"4151_CR94","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1590\/1414-431X20122230","volume":"46","author":"S Ferreira","year":"2013","unstructured":"Ferreira S et al (2013) Effects of melatonin on DNA damage induced by cyclophosphamide in rats. Braz J Med Biol Res 46(3):278\u2013286","journal-title":"Braz J Med Biol Res"},{"issue":"2","key":"4151_CR95","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1385\/CBB:34:2:237","volume":"34","author":"RJ Reiter","year":"2001","unstructured":"Reiter RJ et al (2001) Biochemical reactivity of melatonin with reactive oxygen and nitrogen species. Cell Biochem Biophys 34(2):237\u2013256","journal-title":"Cell Biochem Biophys"},{"issue":"2","key":"4151_CR96","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.theriogenology.2013.04.008","volume":"80","author":"WA Khalil","year":"2013","unstructured":"Khalil WA, Marei WF, Khalid M (2013) Protective effects of antioxidants on linoleic acid\u2013treated bovine oocytes during maturation and subsequent embryo development. Theriogenology 80(2):161\u2013168","journal-title":"Theriogenology"},{"issue":"1","key":"4151_CR97","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1097\/AOG.0000000000000592","volume":"125","author":"M Hamdan","year":"2015","unstructured":"Hamdan M et al (2015) Influence of endometriosis on assisted reproductive technology outcomes: a systematic review and meta-analysis. Obstet Gynecol 125(1):79\u201388","journal-title":"Obstet Gynecol"},{"issue":"2","key":"4151_CR98","doi-asserted-by":"publisher","first-page":"143","DOI":"10.4103\/0974-1208.138874","volume":"7","author":"N Singh","year":"2014","unstructured":"Singh N et al (2014) Effect of endometriosis on implantation rates when compared to tubal factor in fresh non donor in vitro fertilization cycles. J Hum Reprod Sci 7(2):143","journal-title":"J Hum Reprod Sci"},{"issue":"5","key":"4151_CR99","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1007\/s10815-015-0466-6","volume":"32","author":"A Ahelik","year":"2015","unstructured":"Ahelik A et al (2015) Systemic oxidative stress could predict assisted reproductive technique outcome. J Assist Reprod Genet 32(5):699\u2013704","journal-title":"J Assist Reprod Genet"},{"issue":"10","key":"4151_CR100","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1096\/fj.02-0752rev","volume":"17","author":"MS Cooke","year":"2003","unstructured":"Cooke MS et al (2003) Oxidative DNA damage: mechanisms, mutation, and disease. FASEB J 17(10):1195\u20131214","journal-title":"FASEB J"},{"key":"4151_CR101","doi-asserted-by":"publisher","first-page":"36994","DOI":"10.1038\/srep36994","volume":"6","author":"M Hamdan","year":"2016","unstructured":"Hamdan M et al (2016) The sensitivity of the DNA damage checkpoint prevents oocyte maturation in endometriosis. Sci Rep 6:36994","journal-title":"Sci Rep"},{"issue":"5","key":"4151_CR102","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1177\/1933719115612130","volume":"23","author":"G Basini","year":"2016","unstructured":"Basini G et al (2016) Swine granulosa cells show typical endothelial cell characteristics. Reprod Sci 23(5):630\u2013637","journal-title":"Reprod Sci"},{"issue":"1","key":"4151_CR103","doi-asserted-by":"publisher","first-page":"R1","DOI":"10.1530\/REP-14-0524","volume":"150","author":"G Basini","year":"2015","unstructured":"Basini G, Grasselli F (2015) Nitric oxide in follicle development and oocyte competence. Reproduction 150(1):R1\u2013R9","journal-title":"Reproduction"},{"issue":"12","key":"4151_CR104","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.1071\/RD16513","volume":"29","author":"G Basini","year":"2017","unstructured":"Basini G et al (2017) Melatonin potentially acts directly on swine ovary by modulating granulosa cell function and angiogenesis. Reprod Fertil Dev 29(12):2305\u20132312","journal-title":"Reprod Fertil Dev"},{"issue":"1","key":"4151_CR105","first-page":"433","volume":"39","author":"A Gonz\u00e1lez-Gonz\u00e1lez","year":"2018","unstructured":"Gonz\u00e1lez-Gonz\u00e1lez A et al (2018) Complementary actions of melatonin on angiogenic factors, the angiopoietin\/Tie2 axis and VEGF, in co-cultures of human endothelial and breast cancer cells. Oncol Rep 39(1):433\u2013441","journal-title":"Oncol Rep"},{"issue":"10","key":"4151_CR106","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1093\/carcin\/bgx054","volume":"38","author":"LGDA Chuffa","year":"2017","unstructured":"Chuffa LGDA, Reiter RJ, Lupi LA (2017) Melatonin as a promising agent to treat ovarian cancer: molecular mechanisms. Carcinogenesis 38(10):945\u2013952","journal-title":"Carcinogenesis"},{"issue":"1","key":"4151_CR107","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/bjc.2013.285","volume":"109","author":"S Carbajo-Pescador","year":"2013","unstructured":"Carbajo-Pescador S et al (2013) Inhibition of VEGF expression through blockade of Hif1\u03b1 and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells. Br J Cancer 109(1):83\u201391","journal-title":"Br J Cancer"},{"issue":"1","key":"4151_CR108","doi-asserted-by":"publisher","first-page":"231","DOI":"10.3892\/ol.2016.4605","volume":"12","author":"J Colombo","year":"2016","unstructured":"Colombo J et al (2016) Effects of melatonin on HIF-1\u03b1 and VEGF expression and on the invasive properties of hepatocarcinoma cells. Oncol Lett 12(1):231\u2013237","journal-title":"Oncol Lett"},{"key":"4151_CR109","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.anireprosci.2016.07.015","volume":"172","author":"Y-M He","year":"2016","unstructured":"He Y-M et al (2016) Melatonin modulates the functions of porcine granulosa cells via its membrane receptor MT2 in vitro. Anim Reprod Sci 172:164\u2013172","journal-title":"Anim Reprod Sci"},{"issue":"11","key":"4151_CR110","doi-asserted-by":"publisher","first-page":"5016","DOI":"10.1210\/en.2009-0096","volume":"150","author":"J Roa","year":"2009","unstructured":"Roa J et al (2009) The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system. Endocrinology 150(11):5016\u20135026","journal-title":"Endocrinology"},{"issue":"12","key":"4151_CR111","doi-asserted-by":"publisher","first-page":"2821","DOI":"10.1016\/j.febslet.2006.04.068","volume":"580","author":"SG Dann","year":"2006","unstructured":"Dann SG, Thomas G (2006) The amino acid sensitive TOR pathway from yeast to mammals. FEBS Lett 580(12):2821\u20132829","journal-title":"FEBS Lett"},{"issue":"14","key":"4151_CR112","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1038\/emboj.2008.119","volume":"27","author":"T Ikenoue","year":"2008","unstructured":"Ikenoue T et al (2008) Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO J 27(14):1919\u20131931","journal-title":"EMBO J"},{"issue":"3","key":"4151_CR113","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.bbapap.2009.12.001","volume":"1804","author":"RJ Dowling","year":"2010","unstructured":"Dowling RJ et al (2010) Dissecting the role of mTOR: lessons from mTOR inhibitors. Biochimica et Biophysica Acta (BBA)-Proteins Proteomics 1804(3):433\u2013439","journal-title":"Biochimica et Biophysica Acta (BBA)-Proteins Proteomics"},{"issue":"9","key":"4151_CR114","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1016\/j.theriogenology.2008.06.091","volume":"70","author":"H Santos","year":"2008","unstructured":"Santos H et al (2008) Ovarian follicular atresia is mediated by heterophagy, autophagy, and apoptosis in Prochilodus argenteus and Leporinus taeniatus (Teleostei: Characiformes). Theriogenology 70(9):1449\u20131460","journal-title":"Theriogenology"},{"key":"4151_CR115","doi-asserted-by":"publisher","first-page":"100","DOI":"10.14715\/cmb\/2017.63.2.16","volume":"63","author":"YB Kandemir","year":"2017","unstructured":"Kandemir YB, Aydin C, Gorgisen G (2017) The effects of melatonin on oxidative stress and prevention of primordial follicle loss via activation of mTOR pathway in the rat ovary. Cell Mol Biol (Noisy le Grand) 63:100\u2013106","journal-title":"Cell Mol Biol (Noisy le Grand)"},{"issue":"2","key":"4151_CR116","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1095\/biolreprod.103.020644","volume":"70","author":"AM Luciano","year":"2004","unstructured":"Luciano AM et al (2004) Role of intracellular cyclic adenosine 3\u2032, 5\u2032-monophosphate concentration and oocyte-cumulus cells communications on the acquisition of the developmental competence during in vitro maturation of bovine oocyte. Biol Reprod 70(2):465\u2013472","journal-title":"Biol Reprod"},{"issue":"2","key":"4151_CR117","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1006\/dbio.2002.0609","volume":"244","author":"RE Thomas","year":"2002","unstructured":"Thomas RE, Armstrong DT, Gilchrist RB (2002) Differential effects of specific phosphodiesterase isoenzyme inhibitors on bovine oocyte meiotic maturation. Dev Biol 244(2):215\u2013225","journal-title":"Dev Biol"},{"issue":"4","key":"4151_CR118","doi-asserted-by":"publisher","first-page":"834","DOI":"10.3390\/ijms18040834","volume":"18","author":"X Tian","year":"2017","unstructured":"Tian X et al (2017) Beneficial effects of melatonin on the in vitro maturation of sheep oocytes and its relation to melatonin receptors. Int J Mol Sci 18(4):834","journal-title":"Int J Mol Sci"},{"key":"4151_CR119","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.critrevonc.2017.12.018","volume":"122","author":"P Kubatka","year":"2018","unstructured":"Kubatka P et al (2018) Melatonin and breast cancer: evidences from preclinical and human studies. Crit Rev Oncol Hematol 122:133\u2013143","journal-title":"Crit Rev Oncol Hematol"},{"issue":"37","key":"4151_CR120","doi-asserted-by":"publisher","first-page":"38294","DOI":"10.1074\/jbc.M403140200","volume":"279","author":"B del R\u00edo","year":"2004","unstructured":"del R\u00edo B et al (2004) Melatonin, an endogenous-specific inhibitor of estrogen receptor \u03b1 via calmodulin. J Biol Chem 279(37):38294\u201338302","journal-title":"J Biol Chem"},{"issue":"1","key":"4151_CR121","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1007\/s12282-016-0690-7","volume":"24","author":"E Nooshinfar","year":"2017","unstructured":"Nooshinfar E et al (2017) Melatonin, an inhibitory agent in breast cancer. Breast Cancer 24(1):42\u201351","journal-title":"Breast Cancer"},{"issue":"7","key":"4151_CR122","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1097\/PAI.0000000000000788","volume":"28","author":"R Goyal","year":"2019","unstructured":"Goyal R et al (2019) Role of melatonin in breast carcinoma: correlation of expression patterns of melatonin-1 receptor with estrogen, progesterone, and HER2 receptors. Appl Immunohistochem Mol Morphol 28(7):518\u2013523","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"4151_CR123","doi-asserted-by":"publisher","first-page":"525","DOI":"10.3389\/fonc.2019.00525","volume":"9","author":"BR Dodda","year":"2019","unstructured":"Dodda BR et al (2019) Co-administering melatonin with an estradiol-progesterone menopausal hormone therapy represses mammary cancer development in a mouse model of HER2-positive breast cancer. Front Oncol 9:525","journal-title":"Front Oncol"},{"issue":"S1","key":"4151_CR124","first-page":"1","volume":"34","author":"M Hasan","year":"2020","unstructured":"Hasan M et al (2020) Anti-cancer effects of melatonin, estrogen, and progesterone hormone therapy in MCF-7 and MDA-MB-231 breast cancer cells. FASEB J 34(S1):1\u20131","journal-title":"FASEB J"},{"issue":"3","key":"4151_CR125","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1111\/1759-7714.12587","volume":"9","author":"T Wang","year":"2018","unstructured":"Wang T et al (2018) Melatonin inhibits the proliferation of breast cancer cells induced by bisphenol A via targeting estrogen receptor-related pathways. Thorac Cancer 9(3):368\u2013375","journal-title":"Thorac Cancer"},{"issue":"4","key":"4151_CR126","doi-asserted-by":"publisher","first-page":"e12467","DOI":"10.1111\/jpi.12467","volume":"64","author":"S Proietti","year":"2018","unstructured":"Proietti S et al (2018) Increase in motility and invasiveness of MCF 7 cancer cells induced by nicotine is abolished by melatonin through inhibition of ERK phosphorylation. J Pineal Res 64(4):e12467","journal-title":"J Pineal Res"},{"issue":"21","key":"4151_CR127","doi-asserted-by":"publisher","first-page":"9628","DOI":"10.1158\/0008-5472.CAN-05-2352","volume":"65","author":"Y Hayashita","year":"2005","unstructured":"Hayashita Y et al (2005) A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. Cancer Res 65(21):9628\u20139632","journal-title":"Cancer Res"},{"issue":"46","key":"4151_CR128","doi-asserted-by":"publisher","first-page":"6176","DOI":"10.1038\/sj.onc.1209912","volume":"25","author":"M Jovanovic","year":"2006","unstructured":"Jovanovic M, Hengartner M (2006) miRNAs and apoptosis: RNAs to die for. Oncogene 25(46):6176\u20136187","journal-title":"Oncogene"},{"issue":"45","key":"4151_CR129","doi-asserted-by":"publisher","first-page":"5959","DOI":"10.1038\/onc.2008.274","volume":"27","author":"R Schickel","year":"2008","unstructured":"Schickel R et al (2008) MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death. Oncogene 27(45):5959\u20135974","journal-title":"Oncogene"},{"issue":"6","key":"4151_CR130","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.tem.2018.03.008","volume":"29","author":"S-C Su","year":"2018","unstructured":"Su S-C et al (2018) Functional interaction between melatonin signaling and noncoding RNAs. Trends Endocrinol Metab 29(6):435\u2013445","journal-title":"Trends Endocrinol Metab"},{"issue":"3","key":"4151_CR131","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1111\/j.1600-079X.2011.00896.x","volume":"51","author":"SE Lee","year":"2011","unstructured":"Lee SE et al (2011) MicroRNA and gene expression analysis of melatonin-exposed human breast cancer cell lines indicating involvement of the anticancer effect. J Pineal Res 51(3):345\u2013352","journal-title":"J Pineal Res"},{"issue":"9","key":"4151_CR132","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.3390\/ijms17091485","volume":"17","author":"S Cerk","year":"2016","unstructured":"Cerk S et al (2016) Current status of long non-coding RNAs in human breast cancer. Int J Mol Sci 17(9):1485","journal-title":"Int J Mol Sci"},{"issue":"4","key":"4151_CR133","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1177\/1534735409353332","volume":"8","author":"SM Hill","year":"2009","unstructured":"Hill SM et al (2009) Molecular mechanisms of melatonin anticancer effects. Integr Cancer Ther 8(4):337\u2013346","journal-title":"Integr Cancer Ther"},{"issue":"1","key":"4151_CR134","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/j.1600-079X.2009.00682.x","volume":"47","author":"SS Joo","year":"2009","unstructured":"Joo SS, Yoo YM (2009) Melatonin induces apoptotic death in LNCaP cells via p38 and JNK pathways: therapeutic implications for prostate cancer. J Pineal Res 47(1):8\u201314","journal-title":"J Pineal Res"},{"issue":"1","key":"4151_CR135","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/j.1600-079X.2004.00206.x","volume":"39","author":"G Cini","year":"2005","unstructured":"Cini G et al (2005) Antiproliferative activity of melatonin by transcriptional inhibition of cyclin D1 expression: a molecular basis for melatonin-induced oncostatic effects. J Pineal Res 39(1):12\u201320","journal-title":"J Pineal Res"},{"issue":"5","key":"4151_CR136","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1038\/sj.bjc.6601626","volume":"90","author":"E Schernhammer","year":"2004","unstructured":"Schernhammer E, Schulmeister K (2004) Melatonin and cancer risk: does light at night compromise physiologic cancer protection by lowering serum melatonin levels? Br J Cancer 90(5):941\u2013943","journal-title":"Br J Cancer"},{"issue":"1","key":"4151_CR137","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-019-47480-2","volume":"9","author":"T-T Pham","year":"2019","unstructured":"Pham T-T et al (2019) Night-shift work, circadian and melatonin pathway related genes and their interaction on breast cancer risk: evidence from a case-control study in Korean women. Sci Rep 9(1):1\u20139","journal-title":"Sci Rep"},{"issue":"14","key":"4151_CR138","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1093\/jnci\/dji190","volume":"97","author":"ES Schernhammer","year":"2005","unstructured":"Schernhammer ES, Hankinson SE (2005) Urinary melatonin levels and breast cancer risk. J Natl Cancer Inst 97(14):1084\u20131087","journal-title":"J Natl Cancer Inst"},{"issue":"5","key":"4151_CR139","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1093\/carcin\/bgt025","volume":"34","author":"R Santoro","year":"2013","unstructured":"Santoro R et al (2013) Blockage of melatonin receptors impairs p53-mediated prevention of DNA damage accumulation. Carcinogenesis 34(5):1051\u20131061","journal-title":"Carcinogenesis"},{"issue":"15","key":"4151_CR140","doi-asserted-by":"publisher","first-page":"20532","DOI":"10.18632\/oncotarget.7978","volume":"7","author":"F Mori","year":"2016","unstructured":"Mori F et al (2016) Multitargeting activity of miR-24 inhibits long-term melatonin anticancer effects. Oncotarget 7(15):20532","journal-title":"Oncotarget"},{"issue":"7","key":"4151_CR141","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/nsmb1250","volume":"14","author":"S Guil","year":"2007","unstructured":"Guil S, C\u00e1ceres JF (2007) The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a. Nat Struct Mol Biol 14(7):591\u2013596","journal-title":"Nat Struct Mol Biol"},{"issue":"3","key":"4151_CR142","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.molcel.2008.10.013","volume":"32","author":"G Michlewski","year":"2008","unstructured":"Michlewski G et al (2008) Posttranscriptional regulation of miRNAs harboring conserved terminal loops. Mol Cell 32(3):383\u2013393","journal-title":"Mol Cell"},{"issue":"1","key":"4151_CR143","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/jpi.12270","volume":"60","author":"TF Borin","year":"2016","unstructured":"Borin TF et al (2016) Melatonin decreases breast cancer metastasis by modulating Rho-associated kinase protein-1 expression. J Pineal Res 60(1):3\u201315","journal-title":"J Pineal Res"},{"issue":"10","key":"4151_CR144","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1158\/2159-8290.CD-17-0550","volume":"7","author":"SO Sulima","year":"2017","unstructured":"Sulima SO et al (2017) How ribosomes translate cancer. Cancer Discov 7(10):1069\u20131087","journal-title":"Cancer Discov"},{"issue":"2","key":"4151_CR145","doi-asserted-by":"publisher","first-page":"301","DOI":"10.2353\/ajpath.2008.070752","volume":"173","author":"L Montanaro","year":"2008","unstructured":"Montanaro L, Trer\u00e9 D, Derenzini M (2008) Nucleolus, ribosomes, and cancer. Am J Pathol 173(2):301\u2013310","journal-title":"Am J Pathol"},{"key":"4151_CR146","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/879746","volume":"2013","author":"JH Jung","year":"2013","unstructured":"Jung JH et al (2013) Melatonin suppresses the expression of 45S preribosomal RNA and upstream binding factor and enhances the antitumor activity of puromycin in MDA-MB-231 breast cancer cells. Evid-Based Complement Altern Med 2013:879746","journal-title":"Evid-Based Complement Altern Med"},{"issue":"1","key":"4151_CR147","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1111\/jpi.12239","volume":"59","author":"S Xiang","year":"2015","unstructured":"Xiang S et al (2015) Doxorubicin resistance in breast cancer is driven by light at night-induced disruption of the circadian melatonin signal. J Pineal Res 59(1):60\u201369","journal-title":"J Pineal Res"},{"issue":"15","key":"4151_CR148","doi-asserted-by":"publisher","first-page":"4099","DOI":"10.1158\/0008-5472.CAN-13-3156","volume":"74","author":"RT Dauchy","year":"2014","unstructured":"Dauchy RT et al (2014) Circadian and melatonin disruption by exposure to light at night drives intrinsic resistance to tamoxifen therapy in breast cancer. Cancer Res 74(15):4099\u20134110","journal-title":"Cancer Res"},{"issue":"2","key":"4151_CR149","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1111\/jpi.12205","volume":"58","author":"C Alonso-Gonz\u00e1lez","year":"2015","unstructured":"Alonso-Gonz\u00e1lez C et al (2015) Melatonin sensitizes human breast cancer cells to ionizing radiation by downregulating proteins involved in double-strand DNA break repair. J Pineal Res 58(2):189\u2013197","journal-title":"J Pineal Res"},{"key":"4151_CR150","doi-asserted-by":"publisher","first-page":"117463","DOI":"10.1016\/j.lfs.2020.117463","volume":"248","author":"M Ezzati","year":"2020","unstructured":"Ezzati M et al (2020) A review on anti-cancer properties of Quercetin in breast cancer. Life Sci 248:117463","journal-title":"Life Sci"},{"issue":"1","key":"4151_CR151","doi-asserted-by":"publisher","first-page":"e85311","DOI":"10.1371\/journal.pone.0085311","volume":"9","author":"BV Jardim-Perassi","year":"2014","unstructured":"Jardim-Perassi BV et al (2014) Effect of melatonin on tumor growth and angiogenesis in xenograft model of breast cancer. PloS One 9(1):e85311","journal-title":"PloS One"},{"issue":"1","key":"4151_CR152","doi-asserted-by":"publisher","first-page":"144","DOI":"10.3109\/07420528.2013.842925","volume":"31","author":"H Schwimmer","year":"2014","unstructured":"Schwimmer H et al (2014) Light at night and melatonin have opposite effects on breast cancer tumors in mice assessed by growth rates and global DNA methylation. Chronobiol Int 31(1):144\u2013150","journal-title":"Chronobiol Int"},{"issue":"11","key":"4151_CR153","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.1210\/me.2012-1071","volume":"26","author":"L Mao","year":"2012","unstructured":"Mao L et al (2012) Circadian gating of epithelial-to-mesenchymal transition in breast cancer cells via melatonin-regulation of GSK3\u03b2. Mol Endocrinol 26(11):1808\u20131820","journal-title":"Mol Endocrinol"},{"issue":"12","key":"4151_CR154","doi-asserted-by":"publisher","first-page":"23074","DOI":"10.3390\/ijms151223074","volume":"15","author":"K Jablonska","year":"2014","unstructured":"Jablonska K et al (2014) Expression of the MT1 melatonin receptor in ovarian cancer cells. Int J Mol Sci 15(12):23074\u201323089","journal-title":"Int J Mol Sci"},{"issue":"4","key":"4151_CR155","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1111\/j.1600-079X.2011.00910.x","volume":"51","author":"S Carbajo-Pescador","year":"2011","unstructured":"Carbajo-Pescador S et al (2011) Melatonin modulation of intracellular signaling pathways in hepatocarcinoma HepG2 cell line: role of the MT1 receptor. J Pineal Res 51(4):463\u2013471","journal-title":"J Pineal Res"},{"issue":"1","key":"4151_CR156","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s12885-015-1032-4","volume":"15","author":"LGA Chuffa","year":"2015","unstructured":"Chuffa LGA et al (2015) Melatonin attenuates the TLR4-mediated inflammatory response through MyD88-and TRIF-dependent signaling pathways in an in vivo model of ovarian cancer. BMC Cancer 15(1):34","journal-title":"BMC Cancer"},{"issue":"9","key":"4151_CR157","doi-asserted-by":"publisher","first-page":"728","DOI":"10.7150\/jca.10196","volume":"5","author":"GM Ferreira","year":"2014","unstructured":"Ferreira GM et al (2014) Melatonin attenuates Her-2, p38 MAPK, p-AKT, and mTOR levels in ovarian carcinoma of ethanol-preferring rats. J Cancer 5(9):728","journal-title":"J Cancer"},{"issue":"2","key":"4151_CR158","doi-asserted-by":"publisher","first-page":"176","DOI":"10.3390\/ijms17020176","volume":"17","author":"C-J Shen","year":"2016","unstructured":"Shen C-J et al (2016) Melatonin suppresses the growth of ovarian cancer cell lines (OVCAR-429 and PA-1) and potentiates the effect of G1 arrest by targeting CDKs. Int J Mol Sci 17(2):176","journal-title":"Int J Mol Sci"},{"issue":"2","key":"4151_CR159","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1111\/j.1600-079X.2011.00935.x","volume":"52","author":"JH Kim","year":"2012","unstructured":"Kim JH et al (2012) Melatonin synergistically enhances cisplatin-induced apoptosis via the dephosphorylation of ERK\/p90 ribosomal S6 kinase\/heat shock protein 27 in SK-OV-3 cells. J Pineal Res 52(2):244\u2013252","journal-title":"J Pineal Res"},{"issue":"5","key":"4151_CR160","first-page":"801","volume":"31","author":"A Zem\u0142a","year":"2017","unstructured":"Zem\u0142a A et al (2017) Melatonin synergizes the chemotherapeutic effect of cisplatin in ovarian cancer cells independently of MT1 melatonin receptors. In vivo 31(5):801\u2013809","journal-title":"In vivo"},{"issue":"1","key":"4151_CR161","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-16940-y","volume":"7","author":"M Akbarzadeh","year":"2017","unstructured":"Akbarzadeh M et al (2017) The potential therapeutic effect of melatonin on human ovarian cancer by inhibition of invasion and migration of cancer stem cells. Sci Rep 7(1):1\u201311","journal-title":"Sci Rep"},{"issue":"11","key":"4151_CR162","first-page":"2531","volume":"116","author":"IC Scarinci","year":"2010","unstructured":"Scarinci IC et al (2010) Cervical cancer prevention: new tools and old barriers. Cancer Interdiscip Int J Am Cancer Soc 116(11):2531\u20132542","journal-title":"Cancer Interdiscip Int J Am Cancer Soc"},{"issue":"1","key":"4151_CR163","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/jpi.12288","volume":"60","author":"R Pariente","year":"2016","unstructured":"Pariente R et al (2016) Melatonin sensitizes human cervical cancer H e L a cells to cisplatin-induced cytotoxicity and apoptosis: effects on oxidative stress and DNA fragmentation. J Pineal Res 60(1):55\u201364","journal-title":"J Pineal Res"},{"issue":"7","key":"4151_CR164","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1007\/s00018-003-2319-1","volume":"60","author":"R Sainz","year":"2003","unstructured":"Sainz R et al (2003) Melatonin and cell death: differential actions on apoptosis in normal and cancer cells. Cell Mol Life Sci CMLS 60(7):1407\u20131426","journal-title":"Cell Mol Life Sci CMLS"},{"key":"4151_CR165","doi-asserted-by":"crossref","unstructured":"Dauchy RT et al (2012) Melatonin inhibition of linoleic acid transport and 13-HODE production in HeLa human cervical adenocarcinoma occurs via receptor-mediated signal transduction. AACR 5167","DOI":"10.1158\/1538-7445.AM2012-5167"},{"key":"4151_CR166","doi-asserted-by":"crossref","unstructured":"Dauchy RT et al (2013) The circadian neurohormone melatonin inhibits aerobic glycolysis (Warburg effect) and fatty acid metabolic signaling in human colorectal and cervical cancer. AACR 4001","DOI":"10.1158\/1538-7445.AM2013-4001"},{"issue":"6","key":"4151_CR167","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1007\/s00395-017-0653-y","volume":"112","author":"MV Cohen","year":"2017","unstructured":"Cohen MV, Downey JM (2017) The impact of irreproducibility and competing protection from P2Y 12 antagonists on the discovery of cardioprotective interventions. Basic Res Cardiol 112(6):64","journal-title":"Basic Res Cardiol"},{"issue":"1","key":"4151_CR168","doi-asserted-by":"publisher","first-page":"e12534","DOI":"10.1111\/jpi.12534","volume":"66","author":"JA Boga","year":"2019","unstructured":"Boga JA et al (2019) Therapeutic potential of melatonin related to its role as an autophagy regulator: a review. J Pineal Res 66(1):e12534","journal-title":"J Pineal Res"},{"issue":"1","key":"4151_CR169","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s12935-019-0777-2","volume":"19","author":"Q Zhao","year":"2019","unstructured":"Zhao Q, Wang W, Cui J (2019) Melatonin enhances TNF-\u03b1-mediated cervical cancer HeLa cells death via suppressing CaMKII\/Parkin\/mitophagy axis. Cancer Cell Int 19(1):58","journal-title":"Cancer Cell Int"},{"issue":"1","key":"4151_CR170","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12935-019-0777-2","volume":"19","author":"Q Zhao","year":"2019","unstructured":"Zhao Q, Wang W, Cui J (2019) Melatonin enhances TNF-\u03b1-mediated cervical cancer HeLa cells death via suppressing CaMKII\/Parkin\/mitophagy axis. Cancer Cell Int 19(1):1\u201312","journal-title":"Cancer Cell Int"},{"issue":"1","key":"4151_CR171","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21332","volume":"66","author":"RL Siegel","year":"2016","unstructured":"Siegel RL, Miller KD, Jemal A (2016) Cancer statistics, 2016. CA Cancer J Clin 66(1):7\u201330","journal-title":"CA Cancer J Clin"},{"issue":"18","key":"4151_CR172","doi-asserted-by":"publisher","first-page":"2787","DOI":"10.1002\/cncr.30094","volume":"122","author":"JN McAlpine","year":"2016","unstructured":"McAlpine JN, Temkin SM, Mackay HJ (2016) Endometrial cancer: not your grandmother\u2019s cancer. Cancer 122(18):2787\u20132798","journal-title":"Cancer"},{"issue":"4","key":"4151_CR173","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1034\/j.1600-079X.2000.280405.x","volume":"28","author":"Y Kanishi","year":"2000","unstructured":"Kanishi Y et al (2000) Differential growth inhibitory effect of melatonin on two endometrial cancer cell lines. J Pineal Res 28(4):227\u2013233","journal-title":"J Pineal Res"},{"issue":"2","key":"4151_CR174","first-page":"109","volume":"21","author":"M Karasek","year":"2000","unstructured":"Karasek M, Kowalski AJ, Zylinska K (2000) Serum melatonin circadian profile in women suffering from the genital tract cancers. Neuroendocrinol Lett 21(2):109\u2013114","journal-title":"Neuroendocrinol Lett"},{"issue":"21","key":"4151_CR175","doi-asserted-by":"publisher","first-page":"10618","DOI":"10.1158\/0008-5472.CAN-07-2485","volume":"67","author":"AN Viswanathan","year":"2007","unstructured":"Viswanathan AN, Hankinson SE, Schernhammer ES (2007) Night shift work and the risk of endometrial cancer. Cancer Res 67(21):10618\u201310622","journal-title":"Cancer Res"},{"issue":"4","key":"4151_CR176","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1007\/s10552-012-9912-2","volume":"23","author":"SR Sturgeon","year":"2012","unstructured":"Sturgeon SR et al (2012) Sleep duration and endometrial cancer risk. Cancer Causes Control 23(4):547\u2013553","journal-title":"Cancer Causes Control"},{"issue":"8","key":"4151_CR177","first-page":"2637","volume":"31","author":"R Ciortea","year":"2011","unstructured":"Ciortea R et al (2011) Effect of melatonin on intra-abdominal fat in correlation with endometrial proliferation in ovariectomized rats. Anticancer Res 31(8):2637\u20132643","journal-title":"Anticancer Res"},{"issue":"34","key":"4151_CR178","doi-asserted-by":"publisher","first-page":"4675","DOI":"10.1038\/sj.onc.1209594","volume":"25","author":"A King","year":"2006","unstructured":"King A, Selak M, Gottlieb E (2006) Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer. Oncogene 25(34):4675\u20134682","journal-title":"Oncogene"},{"key":"4151_CR179","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.canlet.2020.02.009","volume":"476","author":"C Gu","year":"2020","unstructured":"Gu C et al (2020) Melatonin alleviates progression of uterine endometrial cancer by suppressing estrogen\/ubiquitin C\/SDHB-mediated succinate accumulation. Cancer Lett 476:34\u201347","journal-title":"Cancer Lett"},{"issue":"2","key":"4151_CR180","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1128\/MCB.01338-07","volume":"28","author":"RD Guzy","year":"2008","unstructured":"Guzy RD et al (2008) Loss of the SdhB, but not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis. Mol Cell Biol 28(2):718\u2013731","journal-title":"Mol Cell Biol"},{"issue":"1","key":"4151_CR181","doi-asserted-by":"publisher","first-page":"djv287","DOI":"10.1093\/jnci\/djv287","volume":"108","author":"N Saxena","year":"2016","unstructured":"Saxena N et al (2016) SDHB-deficient cancers: the role of mutations that impair iron sulfur cluster delivery. JNCI J Natl Cancer Inst 108(1):djv287","journal-title":"JNCI J Natl Cancer Inst"},{"issue":"2","key":"4151_CR182","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1046\/j.1439-0434.2002.00691_2.x-i1","volume":"35","author":"Y Kobayashi","year":"2003","unstructured":"Kobayashi Y et al (2003) Melatonin binding sites in estrogen receptor-positive cells derived from human endometrial cancer. J Pineal Res 35(2):71\u201374","journal-title":"J Pineal Res"},{"issue":"3","key":"4151_CR183","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s13577-017-0169-7","volume":"30","author":"K Osanai","year":"2017","unstructured":"Osanai K et al (2017) Ramelteon, a selective MT1\/MT2 receptor agonist, suppresses the proliferation and invasiveness of endometrial cancer cells. Hum Cell 30(3):209\u2013215","journal-title":"Hum Cell"},{"issue":"12","key":"4151_CR184","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1038\/nrc3397","volume":"12","author":"A Umar","year":"2012","unstructured":"Umar A, Dunn BK, Greenwald P (2012) Future directions in cancer prevention. Nat Rev Cancer 12(12):835\u2013848","journal-title":"Nat Rev Cancer"},{"issue":"10","key":"4151_CR185","doi-asserted-by":"publisher","first-page":"2575","DOI":"10.1200\/JCO.2002.11.004","volume":"20","author":"G Vijayalaxmi","year":"2002","unstructured":"Vijayalaxmi G et al (2002) Melatonin: from basic research to cancer treatment clinics. J Clin Oncol 20(10):2575\u20132601","journal-title":"J Clin Oncol"},{"issue":"1","key":"4151_CR186","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2121-14-1","volume":"14","author":"R Liu","year":"2013","unstructured":"Liu R et al (2013) Melatonin enhances DNA repair capacity possibly by affecting genes involved in DNA damage responsive pathways. BMC Cell Biol 14(1):1","journal-title":"BMC Cell Biol"},{"issue":"1","key":"4151_CR187","doi-asserted-by":"publisher","first-page":"81","DOI":"10.32794\/mr11250050","volume":"3","author":"S Xiang","year":"2020","unstructured":"Xiang S et al (2020) Retinoic acid-related orphan receptor alpha 1 (ROR\u03b11) induction of AKR1C3 promotes MCF-7 breast cancer cell proliferation and tamoxifen-resistance which is suppressed by melatonin. Melatonin Res 3(1):81\u2013100","journal-title":"Melatonin Res"},{"issue":"2","key":"4151_CR188","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1002\/1097-0142(19890715)64:2<426::AID-CNCR2820640215>3.0.CO;2-O","volume":"64","author":"C Bartsch","year":"1989","unstructured":"Bartsch C et al (1989) Stage-dependent depression of melatonin in patients with primary breast cancer. Correlation with prolactin, thyroid stimulating hormone, and steroid receptors. Cancer 64(2):426\u2013433","journal-title":"Cancer"},{"issue":"7","key":"4151_CR189","first-page":"2747","volume":"32","author":"A Cutando","year":"2012","unstructured":"Cutando A et al (2012) Role of melatonin in cancer treatment. Anticancer Res 32(7):2747\u20132753","journal-title":"Anticancer Res"},{"issue":"4","key":"4151_CR190","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.sleep.2014.11.017","volume":"16","author":"P Wang","year":"2015","unstructured":"Wang P et al (2015) Night-shift work, sleep duration, daytime napping, and breast cancer risk. Sleep Med 16(4):462\u2013468","journal-title":"Sleep Med"},{"issue":"2","key":"4151_CR191","doi-asserted-by":"publisher","first-page":"108","DOI":"10.2174\/187221412800604581","volume":"6","author":"JE Sanchez-Barcelo","year":"2012","unstructured":"Sanchez-Barcelo JE et al (2012) Breast cancer therapy based on melatonin. Recent Patents Endocr Metab Immune Drug Discov 6(2):108\u2013116","journal-title":"Recent Patents Endocr Metab Immune Drug Discov"},{"issue":"12","key":"4151_CR192","doi-asserted-by":"publisher","first-page":"21670","DOI":"10.1002\/jcp.28865","volume":"234","author":"R Shafabakhsh","year":"2019","unstructured":"Shafabakhsh R et al (2019) Melatonin: a new inhibitor agent for cervical cancer treatment. J Cell Physiol 234(12):21670\u201321682","journal-title":"J Cell Physiol"},{"issue":"3","key":"4151_CR193","doi-asserted-by":"publisher","first-page":"170","DOI":"10.4103\/2096-2924.268154","volume":"3","author":"KD Baboo","year":"2019","unstructured":"Baboo KD, Chen Z-Y, Zhang X-M (2019) Role of oxidative stress and antioxidant therapies in endometriosis. Reprod Dev Med 3(3):170","journal-title":"Reprod Dev Med"},{"issue":"12","key":"4151_CR194","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.3390\/molecules22122059","volume":"22","author":"M Yang","year":"2017","unstructured":"Yang M et al (2017) Melatonin improves the quality of inferior bovine oocytes and promoted their subsequent IVF embryo development: mechanisms and results. Molecules 22(12):2059","journal-title":"Molecules"},{"issue":"3","key":"4151_CR195","doi-asserted-by":"publisher","first-page":"e12424","DOI":"10.1111\/jpi.12424","volume":"63","author":"S Lee","year":"2017","unstructured":"Lee S et al (2017) Melatonin influences the sonic hedgehog signaling pathway in porcine cumulus oocyte complexes. J Pineal Res 63(3):e12424","journal-title":"J Pineal Res"},{"issue":"1","key":"4151_CR196","doi-asserted-by":"publisher","first-page":"e12445","DOI":"10.1111\/jpi.12445","volume":"64","author":"XM Zhao","year":"2018","unstructured":"Zhao XM et al (2018) Melatonin improves the fertilization capacity and developmental ability of bovine oocytes by regulating cytoplasmic maturation events. J Pineal Res 64(1):e12445","journal-title":"J Pineal Res"},{"issue":"1","key":"4151_CR197","first-page":"108","volume":"20","author":"M Ezzati","year":"2018","unstructured":"Ezzati M, Roshangar L, Soleimani J (2018) Evaluating the effect of melatonin on HAS2, and PGR expression, as well as cumulus expansion, and fertility potential in mice. Cell J (Yakhteh) 20(1):108","journal-title":"Cell J (Yakhteh)"},{"issue":"9","key":"4151_CR198","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1111\/asj.12779","volume":"88","author":"Z Chen","year":"2017","unstructured":"Chen Z et al (2017) Effects of melatonin on maturation, histone acetylation, autophagy of porcine oocytes and subsequent embryonic development. Anim Sci J 88(9):1298\u20131310","journal-title":"Anim Sci J"},{"issue":"2","key":"4151_CR199","doi-asserted-by":"publisher","first-page":"494","DOI":"10.3390\/molecules23020494","volume":"23","author":"Y Fang","year":"2018","unstructured":"Fang Y et al (2018) Melatonin-mediated development of ovine cumulus cells, perhaps by regulation of DNA methylation. Molecules 23(2):494","journal-title":"Molecules"},{"key":"4151_CR200","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/j.omtn.2019.12.019","volume":"19","author":"P Liu","year":"2020","unstructured":"Liu P et al (2020) Melatonin regulates breast cancer progression by the lnc010561\/miR-30\/FKBP3 axis. Mol Ther Nucleic Acids 19:765\u2013774","journal-title":"Mol Ther Nucleic Acids"},{"key":"4151_CR201","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.lfs.2018.07.012","volume":"208","author":"JH Marques","year":"2018","unstructured":"Marques JH et al (2018) Melatonin restrains angiogenic factors in triple-negative breast cancer by targeting miR-152-3p: in vivo and in vitro studies. Life Sci 208:131\u2013138","journal-title":"Life Sci"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-021-04151-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-021-04151-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-021-04151-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T15:24:50Z","timestamp":1675178690000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-021-04151-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,17]]},"references-count":201,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["4151"],"URL":"https:\/\/doi.org\/10.1007\/s11010-021-04151-z","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,17]]},"assertion":[{"value":"3 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}