{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:33:37Z","timestamp":1791516817776,"version":"4.3.4"},"reference-count":81,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T00:00:00Z","timestamp":1620604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T00:00:00Z","timestamp":1620604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1007\/s11010-021-04173-7","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T14:04:23Z","timestamp":1620655463000},"page":"3433-3448","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["The protective potential of alpha lipoic acid on amiodarone-induced pulmonary fibrosis and hepatic injury in rats"],"prefix":"10.1007","volume":"476","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3665-3153","authenticated-orcid":false,"given":"Ghadha","family":"Ibrahim Fouad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"R. Mousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,10]]},"reference":[{"key":"4173_CR1","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s40089-014-0113-8","volume":"4","author":"M Ajdari","year":"2014","unstructured":"Ajdari M, Ghahnavieh MZ (2014) Histopathology effects of nickel nanoparticles on lungs, liver, and spleen tissues in male mice. Int Nano Lett 4:113. https:\/\/doi.org\/10.1007\/s40089-014-0113-8","journal-title":"Int Nano Lett"},{"issue":"1","key":"4173_CR2","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/1465-9921-13-39","volume":"13","author":"O Matsuno","year":"2012","unstructured":"Matsuno O (2012) Drug-induced interstitial lung disease: mechanisms and best diagnostic approaches. Respir Res 13(1):39. https:\/\/doi.org\/10.1186\/1465-9921-13-39","journal-title":"Respir Res"},{"issue":"10","key":"4173_CR3","doi-asserted-by":"publisher","first-page":"356","DOI":"10.3390\/jcm7100356","volume":"7","author":"S Skeoch","year":"2018","unstructured":"Skeoch S, Weatherley N, Swift AJ et al (2018) Drug-induced interstitial lung disease: a systematic review. J Clin Med 7(10):356. https:\/\/doi.org\/10.3390\/jcm7100356","journal-title":"J Clin Med"},{"key":"4173_CR4","doi-asserted-by":"publisher","first-page":"19","DOI":"10.4103\/0973-3698.272161","volume":"14","author":"WI Lee","year":"2019","unstructured":"Lee WI, Hissaria P (2019) Drug-induced interstitial lung disease. Indian J Rheumatol 14:19\u201326. https:\/\/doi.org\/10.4103\/0973-3698.272161","journal-title":"Indian J Rheumatol"},{"issue":"124","key":"4173_CR5","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1183\/09059180.00001112","volume":"21","author":"V Cottin","year":"2012","unstructured":"Cottin V (2012) Changing the idiopathic pulmonary fibrosis treatment approach and improving patient outcomes. Eur Respir Rev 21(124):161\u2013167","journal-title":"Eur Respir Rev"},{"issue":"10","key":"4173_CR6","first-page":"695","volume":"7","author":"JM Fenkel","year":"2011","unstructured":"Fenkel JM, Navarro VJ (2011) Herbal and dietary supplement-induced liver injury. Gastroenterol Hepatol (NY) 7(10):695\u2013696","journal-title":"Gastroenterol Hepatol (NY)"},{"key":"4173_CR7","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1007\/s40495-018-0136-3","volume":"4","author":"S Chopra","year":"2018","unstructured":"Chopra S, Saxena R (2018) Drug-induced liver injury\u2014perspectives from pathology. Curr Pharmacol Rep 4:182\u2013192. https:\/\/doi.org\/10.1007\/s40495-018-0136-3","journal-title":"Curr Pharmacol Rep"},{"issue":"2","key":"4173_CR8","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1517\/14740338.2012.660915","volume":"11","author":"P Santangeli","year":"2012","unstructured":"Santangeli P, Di Biase L, Burkhardt JD et al (2012) Examining the safety of amiodarone. Expert Opin Drug Saf 11(2):191\u2013214. https:\/\/doi.org\/10.1517\/14740338.2012.660915","journal-title":"Expert Opin Drug Saf"},{"issue":"3","key":"4173_CR9","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1159\/000358641","volume":"33","author":"Y Wang","year":"2014","unstructured":"Wang Y, Chen MS, Liu HC, Xiao JH, Wang JL (2014) The relationship between frequency dependence of action potential duration and the expression of TRPC3 in rabbit ventricular myocardium. Cell Physiol Biochem 33(3):646\u2013656. https:\/\/doi.org\/10.1159\/000358641","journal-title":"Cell Physiol Biochem"},{"issue":"2","key":"4173_CR10","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/0002-8703(85)90158-9","volume":"110","author":"GC Flaker","year":"1985","unstructured":"Flaker GC, Alpert MA, Webel RR, Ruder MA, Sanfelippo JF, Tsutakawa RK (1985) Amiodarone and sustained ventricular arrhythmias: statistical evidence of drug effectiveness. Am Heart J 110(2):371\u2013376. https:\/\/doi.org\/10.1016\/0002-8703(85)90158-9","journal-title":"Am Heart J"},{"issue":"2","key":"4173_CR11","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1210\/edrv.22.2.0427","volume":"22","author":"E Martino","year":"2001","unstructured":"Martino E, Bartalena L, Bogazzi F, Braverman LE (2001) The effects of amiodarone on the thyroid. Endocr Rev 22(2):240\u2013254. https:\/\/doi.org\/10.1210\/edrv.22.2.0427","journal-title":"Endocr Rev"},{"issue":"6","key":"4173_CR12","doi-asserted-by":"publisher","first-page":"667","DOI":"10.3978\/j.issn.2072-1439.2012.06.08","volume":"4","author":"N Nacca","year":"2012","unstructured":"Nacca N, Bhamidipati CM, Yuhico LS, Pinnamaneni S, Szombathy T (2012) Severe amiodarone induced pulmonary toxicity. J Thorac Dis 4(6):667\u2013670. https:\/\/doi.org\/10.3978\/j.issn.2072-1439.2012.06.08","journal-title":"J Thorac Dis"},{"issue":"6","key":"4173_CR13","doi-asserted-by":"publisher","first-page":"2311","DOI":"10.1159\/000445585","volume":"38","author":"LQ Jiang","year":"2016","unstructured":"Jiang LQ, Chen SJ, Xu JJ, Ran Z, Ying W, Zhao SG (2016) Dronedarone and amiodarone induce dyslipidemia and thyroid dysfunction in rats. Cell Physiol Biochem 38(6):2311\u20132322. https:\/\/doi.org\/10.1159\/000445585","journal-title":"Cell Physiol Biochem"},{"key":"4173_CR14","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/s13256-018-1629-8","volume":"12","author":"T Tsuda","year":"2018","unstructured":"Tsuda T, Tada H, Tanaka Y et al (2018) Amiodarone-induced reversible and irreversible hepatotoxicity: two case reports. J Med Case Rep 12:95. https:\/\/doi.org\/10.1186\/s13256-018-1629-8","journal-title":"J Med Case Rep"},{"issue":"19","key":"4173_CR15","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1136\/hrt.2008.152652","volume":"96","author":"L van Erven","year":"2010","unstructured":"van Erven L, Schalij MJ (2010) Amiodarone: an effective antiarrhythmic drug with unusual side effects. Heart 96(19):1593\u20131600. https:\/\/doi.org\/10.1136\/hrt.2008.152652","journal-title":"Heart"},{"key":"4173_CR16","doi-asserted-by":"publisher","first-page":"6265853","DOI":"10.1155\/2016\/6265853","volume":"2016","author":"B Al-Shammari","year":"2016","unstructured":"Al-Shammari B, Khalifa M, Bakheet SA, Yasser M (2016) A mechanistic study on the amiodarone-induced pulmonary toxicity. Oxid Med Cell Longev 2016:6265853. https:\/\/doi.org\/10.1155\/2016\/6265853","journal-title":"Oxid Med Cell Longev"},{"issue":"1","key":"4173_CR17","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1111\/jcpt.12594","volume":"43","author":"P Jaiswal","year":"2018","unstructured":"Jaiswal P, Attar BM, Yap JE et al (2018) Acute liver failure with amiodarone infusion: a case report and systematic review. J Clin Pharm Ther 43(1):129\u2013133. https:\/\/doi.org\/10.1111\/jcpt.12594","journal-title":"J Clin Pharm Ther"},{"key":"4173_CR18","doi-asserted-by":"publisher","first-page":"617943","DOI":"10.1155\/2013\/617943","volume":"2013","author":"N Hussain","year":"2013","unstructured":"Hussain N, Bhattacharyya A, Prueksaritanond S (2013) Amiodarone-induced cirrhosis of liver: what predicts mortality? ISRN Cardiol 2013:617943. https:\/\/doi.org\/10.1155\/2013\/617943","journal-title":"ISRN Cardiol"},{"issue":"5","key":"4173_CR19","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1179\/135100010X12826446921464","volume":"15","author":"M Valdecantos","year":"2010","unstructured":"Valdecantos M, P\u00e9rez-Matute P, Quintero P, Mart\u00ednez JA (2010) Vitamin C, resveratrol and lipoic acid actions on isolated rat liver mitochondria: all antioxidants but different. Redox Rep 15(5):207\u2013216. https:\/\/doi.org\/10.1179\/135100010X12826446921464","journal-title":"Redox Rep"},{"issue":"3","key":"4173_CR20","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.bbrc.2016.02.119","volume":"472","author":"K Chen","year":"2016","unstructured":"Chen K, Yan B, Wang F et al (2016) Type 1 5\u2019-deiodinase activity is inhibited by oxidative stress and restored by alpha-lipoic acid in HepG2 cells. Biochem Biophys Res Commun 472(3):496\u2013501. https:\/\/doi.org\/10.1016\/j.bbrc.2016.02.119","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"4173_CR21","doi-asserted-by":"publisher","first-page":"309","DOI":"10.5152\/balkanmedj.2013.8426","volume":"30","author":"FG Bulmu\u015f","year":"2013","unstructured":"Bulmu\u015f FG, G\u00fcrsu MF, Muz MH, Yaman I, Bulmu\u015f O, Sakin F (2013) Protective effects of alpha-lipoic acid on oleic acid-induced acute lung injury in rats. Balk Med J 30(3):309\u2013314. https:\/\/doi.org\/10.5152\/balkanmedj.2013.8426","journal-title":"Balk Med J"},{"key":"4173_CR22","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1007\/s10753-019-01020-2","volume":"42","author":"N Erol","year":"2019","unstructured":"Erol N, Saglam L, Saglam YS et al (2019) The protection potential of antioxidant vitamins against acute respiratory distress syndrome: a rat trial. Inflammation 42:1585\u20131594. https:\/\/doi.org\/10.1007\/s10753-019-01020-2","journal-title":"Inflammation"},{"key":"4173_CR23","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/590363","author":"YC Lin","year":"2013","unstructured":"Lin YC, Lai YS, Chou TC (2013) The protective effect of alpha-lipoic acid in lipopolysaccharide-induced acute lung injury is mediated by heme oxygenase-1. Evid Based Complement Altern Med. https:\/\/doi.org\/10.1155\/2013\/590363","journal-title":"Evid Based Complement Altern Med"},{"issue":"5","key":"4173_CR24","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1097\/SHK.0b013e3181c3cf0e","volume":"33","author":"E Cadirci","year":"2010","unstructured":"Cadirci E, Altunkaynak BZ, Halici Z, Odabasoglu F, Uyanik MH et al (2010) Alpha-lipoic acid as a potential target for the treatment of lung injury caused by cecal ligation and puncture-induced sepsis model in rats. Shock 33(5):479\u2013484. https:\/\/doi.org\/10.1097\/SHK.0b013e3181c3cf0e","journal-title":"Shock"},{"issue":"2","key":"4173_CR25","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1080\/08941939.2017.1296513","volume":"31","author":"H Arpag","year":"2018","unstructured":"Arpag H, G\u00fcl M, Aydemir Y et al (2018) Protective effects of alpha-lipoic acid on methotrexate-induced oxidative lung injury in rats. J Investig Surg 31(2):107\u2013113. https:\/\/doi.org\/10.1080\/08941939.2017.1296513","journal-title":"J Investig Surg"},{"issue":"5","key":"4173_CR26","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1139\/cjpp-2016-0366","volume":"95","author":"H Ateyya","year":"2017","unstructured":"Ateyya H, Nader MA, Attia GM, El-Sherbeeny NA (2017) Influence of alpha-lipoic acid on nicotine-induced lung and liver damage in experimental rats. Can J Physiol Pharmacol 95(5):492\u2013500","journal-title":"Can J Physiol Pharmacol"},{"issue":"129","key":"4173_CR27","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1183\/09059180.00002113","volume":"22","author":"K Antoniou","year":"2013","unstructured":"Antoniou K, Margaritopoulos G, Siafakas N (2013) Pharmacological treatment of idiopathic pulmonary fibrosis: from the past to the future. Eur Respir Rev 22(129):281\u2013291. https:\/\/doi.org\/10.1183\/09059180.00002113","journal-title":"Eur Respir Rev"},{"key":"4173_CR28","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.biochi.2018.10.002","volume":"156","author":"AI Abd El-Fattah","year":"2019","unstructured":"Abd El-Fattah AI, Zaghloul MS, Eltablawy NA, Rashed LA (2019) \u03b1-Lipoic acid and amlodipine\/perindopril combination potentiate the therapeutic effect of mesenchymal stem cells on isoproterenol induced cardiac injury in rats. Biochimie 156:59\u201368. https:\/\/doi.org\/10.1016\/j.biochi.2018.10.002","journal-title":"Biochimie"},{"issue":"1","key":"4173_CR29","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1111\/bcpt.12551","volume":"119","author":"AA Sharaf El-Din","year":"2016","unstructured":"Sharaf El-Din AA, Abd Allah OM (2016) Impact of olmesartan medoxomil on amiodarone-induced pulmonary toxicity in rats: focus on transforming growth factor-\u00df1. Basic Clin Pharmacol Toxicol 119(1):58\u201367. https:\/\/doi.org\/10.1111\/bcpt.12551","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"1","key":"4173_CR30","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/S0021-9258(19)51149-8","volume":"184","author":"RE Neuman","year":"1950","unstructured":"Neuman RE, Logan MA (1950) The determination of hydroxyproline. J Biol Chem 184(1):299\u2013306","journal-title":"J Biol Chem"},{"issue":"4","key":"4173_CR31","first-page":"349","volume":"4","author":"CR Kliment","year":"2011","unstructured":"Kliment CR, Englert JM, Crum LP, Oury TD (2011) A novel method for accurate collagen and biochemical assessment of pulmonary tissue utilizing one animal. Int J Clin Exp Pathol 4(4):349\u2013355","journal-title":"Int J Clin Exp Pathol"},{"issue":"2","key":"4173_CR32","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95(2):351\u2013358. https:\/\/doi.org\/10.1016\/0003-2697(79)90738-3","journal-title":"Anal Biochem"},{"key":"4173_CR33","first-page":"882","volume":"61","author":"E Beutler","year":"1963","unstructured":"Beutler E, Duron O, Kelly BM (1963) Improved method for the determination of blood glutathione. J Lab Clin Med 61:882\u2013888","journal-title":"J Lab Clin Med"},{"issue":"5","key":"4173_CR34","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1136\/jcp.54.5.356","volume":"54","author":"D Koracevic","year":"2001","unstructured":"Koracevic D, Koracevic G, Djordjevic V, Andrejevic S, Cosic V (2001) Method for the measurement of antioxidant activity in human fluids. J Clin Pathol 54(5):356\u2013361. https:\/\/doi.org\/10.1136\/jcp.54.5.356","journal-title":"J Clin Pathol"},{"issue":"1","key":"4173_CR35","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1093\/ajcp\/28.1.56","volume":"28","author":"S Reitman","year":"1957","unstructured":"Reitman S, Frankel S (1957) A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol 28(1):56\u201363. https:\/\/doi.org\/10.1093\/ajcp\/28.1.56","journal-title":"Am J Clin Pathol"},{"issue":"4","key":"4173_CR36","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1093\/clinchem\/20.4.470","volume":"20","author":"CC Allain","year":"1974","unstructured":"Allain CC, Poon LS, Chan CS, Richmond W, Fu PC (1974) Enzymatic determination of total serum cholesterol. Clin Chem 20(4):470\u2013475","journal-title":"Clin Chem"},{"issue":"1","key":"4173_CR37","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1177\/000456326900600108","volume":"6","author":"P Trinder","year":"1969","unstructured":"Trinder P (1969) Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. Ann Clin Biochem 6(1):24\u201325","journal-title":"Ann Clin Biochem"},{"issue":"4","key":"4173_CR38","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1097\/SHK.0000000000000302","volume":"43","author":"Y Li","year":"2015","unstructured":"Li Y, Zeng Z, Li Y et al (2015) Angiotensin-converting enzyme inhibition attenuates lipopolysaccharide-induced lung injury by regulating the balance between angiotensin-converting enzyme and angiotensin-converting enzyme 2 and inhibiting mitogen-activated protein kinase activation. Shock 43(4):395\u2013404. https:\/\/doi.org\/10.1097\/SHK.0000000000000302","journal-title":"Shock"},{"issue":"1\u20133","key":"4173_CR39","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.ejphar.2013.06.004","volume":"714","author":"CH Niu","year":"2013","unstructured":"Niu CH, Wang Y, Liu JD, Wang JL, Xiao JH (2013) Protective effects of neferine on amiodarone-induced pulmonary fibrosis in mice. Eur J Pharmacol 714(1\u20133):112\u2013119. https:\/\/doi.org\/10.1016\/j.ejphar.2013.06.004","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"4173_CR40","doi-asserted-by":"publisher","first-page":"491","DOI":"10.22159\/ajpcr.2019.v12i1.30368","volume":"12","author":"BAR Mshimesh","year":"2019","unstructured":"Mshimesh BAR (2019) Antifibrotic activity of mesna against amiodarone-associated lung injury in Wistar rats. Asian J Pharm Clin Res 12(1):491\u2013496","journal-title":"Asian J Pharm Clin Res"},{"issue":"2","key":"4173_CR41","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1097\/01.mcp.0000152998.11335.24","volume":"11","author":"B Rimal","year":"2005","unstructured":"Rimal B, Greenberg AK, Rom WN (2005) Basic pathogenetic mechanisms in silicosis: current understanding. Curr Opin Pulm Med 11(2):169\u2013173. https:\/\/doi.org\/10.1097\/01.mcp.0000152998.11335.24","journal-title":"Curr Opin Pulm Med"},{"key":"4173_CR42","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.biopha.2018.09.032","volume":"108","author":"M Raish","year":"2018","unstructured":"Raish M, Ahmad A, Ahmad Ansari M et al (2018) Sinapic acid ameliorates bleomycin-induced lung fibrosis in rats. Biomed Pharmacother 108:224\u2013231. https:\/\/doi.org\/10.1016\/j.biopha.2018.09.032","journal-title":"Biomed Pharmacother"},{"issue":"7","key":"4173_CR43","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1038\/sj.bjp.0705362","volume":"139","author":"D Punithavathi","year":"2003","unstructured":"Punithavathi D, Venkatesan N, Babu M (2003) Protective effects of curcumin against amiodarone-induced pulmonary fibrosis in rats. Br J Pharmacol 139(7):1342\u20131350. https:\/\/doi.org\/10.1038\/sj.bjp.0705362","journal-title":"Br J Pharmacol"},{"issue":"3","key":"4173_CR44","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1513\/pats.201203-023AW","volume":"9","author":"IE Fernandez","year":"2012","unstructured":"Fernandez IE, Eickelberg O (2012) The impact of TGF-\u03b2 on lung fibrosis: from targeting to biomarkers. Proc Am Thorac Soc 9(3):111\u2013116. https:\/\/doi.org\/10.1513\/pats.201203-023AW","journal-title":"Proc Am Thorac Soc"},{"issue":"2","key":"4173_CR45","doi-asserted-by":"publisher","first-page":"133","DOI":"10.15283\/ijsc.2011.4.2.133","volume":"4","author":"SS Zaglool","year":"2011","unstructured":"Zaglool SS, Zickri MB, Abd El Aziz DH, Mabrouk D, Metwally HG (2011) Effect of stem cell therapy on amiodarone induced fibrosing interstitial lung disease in albino rat. Int J Stem Cells 4(2):133\u2013142. https:\/\/doi.org\/10.15283\/ijsc.2011.4.2.133","journal-title":"Int J Stem Cells"},{"issue":"4","key":"4173_CR46","first-page":"323","volume":"22","author":"FA Gawad","year":"2018","unstructured":"Gawad FA, Rizk AA, Jouakim MF, Abd El Halem MZ (2018) Amiodarone-induced lung toxicity and the protective role of Vitamin E in adult male albino rat. Eur J Anat 22(4):323\u2013333","journal-title":"Eur J Anat"},{"issue":"7","key":"4173_CR47","doi-asserted-by":"publisher","first-page":"7915","DOI":"10.3390\/ijms13077915","volume":"13","author":"SJ Park","year":"2012","unstructured":"Park SJ, Lee KS, Lee SJ, Kim SR, Park SY, Jeon MS et al (2012) L-2- oxothiazolidine-4-carboxylic acid or \u03b1-lipoic acid attenuates airway remodeling: involvement of nuclear factor-\u03baB (NF-\u03baB), nuclear factor erythroid 2p45-related factor-2 (Nrf2), and hypoxiainducible factor (HIF). Int J Mol Scis 13(7):7915\u20137937. https:\/\/doi.org\/10.3390\/ijms13077915","journal-title":"Int J Mol Scis"},{"issue":"3\u20134","key":"4173_CR48","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1080\/01902148.2020.1728595","volume":"46","author":"ET Kozima","year":"2020","unstructured":"Kozima ET, Souza ABF, Castro TF et al (2020) Aluminum hydroxide nebulization-induced redox imbalance and acute lung inflammation in mice. Exp Lung Res 46(3\u20134):64\u201374. https:\/\/doi.org\/10.1080\/01902148.2020.1728595","journal-title":"Exp Lung Res"},{"key":"4173_CR49","doi-asserted-by":"publisher","first-page":"105","DOI":"10.4137\/BMI.S10009","volume":"7","author":"T Liu","year":"2012","unstructured":"Liu T, Wang X, Karsdal MA, Leeming DJ, Genovese F (2012) Molecular serum markers of liver fibrosis. Biomark Insights 7:105\u2013117. https:\/\/doi.org\/10.4137\/BMI.S10009","journal-title":"Biomark Insights"},{"key":"4173_CR50","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-32794-5-4","volume-title":"In: Guide to clinical management of idiopathic pulmonary fibrosis","author":"SD Nathan","year":"2016","unstructured":"Nathan SD, Brown AW, King CS (2016) Pathogenesis of idiopathic pulmonary fibrosis. In: Guide to clinical management of idiopathic pulmonary fibrosis. Adis, Cham. https:\/\/doi.org\/10.1007\/978-3-319-32794-5-4"},{"issue":"6","key":"4173_CR51","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1002\/cbf.3118","volume":"33","author":"SH Yu","year":"2015","unstructured":"Yu SH, Liu LJ, Lv B et al (2015) Inhibition of bleomycin-induced pulmonary fibrosis by bone marrow-derived mesenchymal stem cells might be mediated by decreasing MMP9, TIMP-1 INF-\u03b3 and TGF-\u03b2. Cell Biochem Funct 33(6):356\u2013366. https:\/\/doi.org\/10.1002\/cbf.3118","journal-title":"Cell Biochem Funct"},{"issue":"1","key":"4173_CR52","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3382\/ps\/pew285","volume":"96","author":"M Lu","year":"2017","unstructured":"Lu M, Bai J, Xu B et al (2017) Effect of alpha-lipoic acid on relieving ammonia stress and hepatic proteomic analyses of broilers. Poult Sci 96(1):88\u201397. https:\/\/doi.org\/10.3382\/ps\/pew285","journal-title":"Poult Sci"},{"issue":"4","key":"4173_CR53","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ejbas.2017.10.005","volume":"4","author":"MS Zaghloul","year":"2017","unstructured":"Zaghloul MS, Abdel-Salam RA, Said E, Suddek GM, Salem HAR (2017) Attenuation of bleomycin-induced pulmonary fibrosis in rats by flavocoxid treatment. Egypt J Basic Appl Sci 4(4):256\u2013263","journal-title":"Egypt J Basic Appl Sci"},{"issue":"9","key":"4173_CR54","doi-asserted-by":"publisher","first-page":"21486","DOI":"10.3390\/ijms160921486","volume":"16","author":"SJ Kim","year":"2015","unstructured":"Kim SJ, Cheresh P, Jablonski RP, Williams DB et al (2015) The role of mitochondrial DNA in mediating alveolar epithelial cell apoptosis and pulmonary fibrosis. Int J Mol Sci 16(9):21486\u201321519. https:\/\/doi.org\/10.3390\/ijms160921486","journal-title":"Int J Mol Sci"},{"key":"4173_CR55","first-page":"1","volume":"10","author":"AM Gado","year":"2013","unstructured":"Gado AM, Aldahmash BA (2013) Protective effect of L-carnitine against amiodarone-induced lung toxicity in rats. Internet J Toxicol 10:1\u20139","journal-title":"Internet J Toxicol"},{"key":"4173_CR56","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.toxrep.2018.05.014","volume":"5","author":"EE Guzel","year":"2018","unstructured":"Guzel EE, Kaya N, Ozan G, Tektemur A, Dabak DO, Ozan IE (2018) The investigation of effect of alpha lipoic acid against damage on neonatal rat lung to maternal tobacco smoke exposure. Toxicol Rep 5:714\u2013722. https:\/\/doi.org\/10.1016\/j.toxrep.2018.05.014","journal-title":"Toxicol Rep"},{"issue":"3","key":"4173_CR57","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.jfma.2013.07.011","volume":"114","author":"JG Li","year":"2015","unstructured":"Li JG, Yang TC, Yu DM, Ren TH (2015) Fatal acute liver failure after intravenous amiodarone administration. J Formos Med Assoc 114(3):294\u2013296. https:\/\/doi.org\/10.1016\/j.jfma.2013.07.011","journal-title":"J Formos Med Assoc"},{"issue":"2","key":"4173_CR58","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.bjbas.2017.12.001","volume":"7","author":"M Abdul-Hamid","year":"2018","unstructured":"Abdul-Hamid M, Galaly SR, Mahmoud H, Mostafa F (2018) The protective effect of grape seed and Ginkgo biloba against hepatotoxicity induced by the antidysrhythmic drug \u201camiodarone\u201d in male albino rats. Beni-Suef Univ J Basic Appl Sci 7(2):223\u2013230","journal-title":"Beni-Suef Univ J Basic Appl Sci"},{"key":"4173_CR59","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.eujim.2015.04.004","volume":"7","author":"E Tanvir","year":"2015","unstructured":"Tanvir E, Afroz R, Chowdhury MAZ, Khalil MI, Hossain MS et al (2015) Honey has a protective effect against chlorpyrifos-induced toxicity on lipid peroxidation, diagnostic markers, and hepatic histoarchitecture. Eur J Integr Med 7:525\u2013533","journal-title":"Eur J Integr Med"},{"issue":"4","key":"4173_CR60","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1002\/hep.510270416","volume":"27","author":"S Roth","year":"1998","unstructured":"Roth S, Michel K, Gressner AM (1998) (Latent) transforming growth factor beta in liver parenchymal cells, its injury-dependent release, and paracrine effects on rat hepatic stellate cells. Hepatology 27(4):1003\u20131012","journal-title":"Hepatology"},{"issue":"47","key":"4173_CR61","first-page":"1369","volume":"49","author":"R Flisiak","year":"2002","unstructured":"Flisiak R, Maxwell P, Prokopowicz D, Timms PM, Panasiuk A (2002) Plasma tissue inhibitor of metalloproteinases-1 and transforming growth factor beta 1-possible non-invasive biomarkers of hepatic fibrosis in patients with chronic B and C hepatitis. Hepatogastroenterology 49(47):1369\u20131372","journal-title":"Hepatogastroenterology"},{"issue":"2","key":"4173_CR62","doi-asserted-by":"publisher","first-page":"116","DOI":"10.14309\/crj.2015.23","volume":"2","author":"J Buggey","year":"2015","unstructured":"Buggey J, Kappus M, Lagoo AS, Brady CW (2015) Amiodarone-induced liver injury and cirrhosis. ACG Case Rep J 2(2):116\u2013118. https:\/\/doi.org\/10.14309\/crj.2015.23","journal-title":"ACG Case Rep J"},{"issue":"4","key":"4173_CR63","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1074\/jbc.275.4.2247","volume":"275","author":"SL Friedman","year":"2000","unstructured":"Friedman SL (2000) Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 275(4):2247\u20132250. https:\/\/doi.org\/10.1074\/jbc.275.4.2247","journal-title":"J Biol Chem"},{"issue":"3","key":"4173_CR64","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.jhep.2010.11.035","volume":"55","author":"Y Liu","year":"2011","unstructured":"Liu Y, Wang Z, Kwong SQ et al (2011) Inhibition of PDGF, TGF-\u03b2, and Abl signaling and reduction of liver fibrosis by the small molecule Bcr-Abl tyrosine kinase antagonist nilotinib. J Hepatol 55(3):612\u2013625. https:\/\/doi.org\/10.1016\/j.jhep.2010.11.035","journal-title":"J Hepatol"},{"key":"4173_CR65","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.etap.2018.02.007","volume":"59","author":"WR Mohamed","year":"2018","unstructured":"Mohamed WR, Mehany AB, Hussein RM (2018) Alpha lipoic acid protects against chlorpyrifos-induced toxicity in Wistar rats via modulating the apoptotic pathway. Environ Toxicol Pharmacol 59:17\u201323","journal-title":"Environ Toxicol Pharmacol"},{"issue":"5","key":"4173_CR66","doi-asserted-by":"publisher","first-page":"181","DOI":"10.3390\/medicina55050181","volume":"55","author":"AM Abdulrazzaq","year":"2019","unstructured":"Abdulrazzaq AM, Badr M, Gammoh O et al (2019) Hepatoprotective actions of ascorbic acid, alpha lipoic acid and silymarin or their combination against acetaminophen-induced hepatotoxicity in rats. Medicina 55(5):181","journal-title":"Medicina"},{"key":"4173_CR67","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.ejphar.2014.01.042","volume":"726","author":"SM Elshazly","year":"2014","unstructured":"Elshazly SM, El-Moselhy MA, Barakat W (2014) Insights in the mechanism underlying the protective effect of \u03b1-lipoic acid against acetaminophen-hepatotoxicity. Eur J Pharmacol 726:116\u2013123. https:\/\/doi.org\/10.1016\/j.ejphar.2014.01.042","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"4173_CR68","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1124\/jpet.104.072785","volume":"311","author":"TC McCarthy","year":"2004","unstructured":"McCarthy TC, Pollak PT, Hanniman EA, Sinal CJ (2004) Disruption of hepatic lipid homeostasis in mice after amiodarone treatment is associated with peroxisome proliferator-activated receptor-alpha target gene activation. J Pharmacol Exp Ther 311(3):864\u2013873. https:\/\/doi.org\/10.1124\/jpet.104.072785","journal-title":"J Pharmacol Exp Ther"},{"issue":"3","key":"4173_CR69","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1177\/0192623311432290","volume":"40","author":"N Mesens","year":"2012","unstructured":"Mesens N, Desmidt M, Verheyen GR et al (2012) Phospholipidosis in rats treated with amiodarone: serum biochemistry and whole genome micro-array analysis supporting the lipid traffic jam hypothesis and the subsequent rise of the biomarker BMP. Toxicol Pathol 40(3):491\u2013503. https:\/\/doi.org\/10.1177\/0192623311432290","journal-title":"Toxicol Pathol"},{"issue":"7","key":"4173_CR70","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1002\/jat.3960","volume":"40","author":"G Kim","year":"2020","unstructured":"Kim G, Choi HK, Lee H et al (2020) Increased hepatic acylcarnitines after oral administration of amiodarone in rats. J Appl Toxicol 40(7):1004\u20131013. https:\/\/doi.org\/10.1002\/jat.3960","journal-title":"J Appl Toxicol"},{"key":"4173_CR71","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1289\/ehp.8455149","volume":"55","author":"AB Fisher","year":"1984","unstructured":"Fisher AB (1984) Intermediary metabolism of the lung. Environ Health Perspect 55:149\u2013158. https:\/\/doi.org\/10.1289\/ehp.8455149","journal-title":"Environ Health Perspect"},{"key":"4173_CR72","unstructured":"Arvind A, Osganian SA, Cohen DE, Corey KE (2019) Lipid and lipoprotein metabolism in liver disease. In: Endotext [Internet]. MDText.com, Inc. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK326742\/. Accessed 15 Oct 2020"},{"issue":"10","key":"4173_CR73","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.biopha.2006.12.003","volume":"62","author":"A Zulkhairi","year":"2008","unstructured":"Zulkhairi A, Zaiton Z, Jamaluddin M et al (2008) Alpha lipoic acid posses dual antioxidant and lipid lowering properties in atherosclerotic-induced New Zealand white rabbit. Biomed Pharmacother 62(10):716\u2013722","journal-title":"Biomed Pharmacother"},{"issue":"6","key":"4173_CR74","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/j.nut.2008.02.002","volume":"24","author":"RL Yang","year":"2008","unstructured":"Yang RL, Li W, Shi YH, Le GW (2008) Lipoic acid prevents high-fat diet-induced dyslipidemia and oxidative stress: a microarray analysis. Nutrition 24(6):582\u2013588. https:\/\/doi.org\/10.1016\/j.nut.2008.02.002","journal-title":"Nutrition"},{"issue":"3","key":"4173_CR75","doi-asserted-by":"publisher","first-page":"e90863","DOI":"10.1371\/journal.pone.0090863","volume":"9","author":"B Carrier","year":"2014","unstructured":"Carrier B, Wen S, Zigouras S et al (2014) Alpha-lipoic acid reduces LDL-particle number and PCSK9 concentrations in high-fat fed obese Zucker rats. PLoS ONE 9(3):e90863. https:\/\/doi.org\/10.1371\/journal.pone.0090863","journal-title":"PLoS ONE"},{"issue":"3","key":"4173_CR76","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/j.bbrc.2005.05.035","volume":"332","author":"WJ Lee","year":"2005","unstructured":"Lee WJ, Song KH, Koh EH et al (2005) Alpha-lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle. Biochem Biophys Res Commun 332(3):885\u2013891. https:\/\/doi.org\/10.1016\/j.bbrc.2005.05.035","journal-title":"Biochem Biophys Res Commun"},{"issue":"8","key":"4173_CR77","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1038\/oby.2011.121","volume":"19","author":"Y Zhang","year":"2011","unstructured":"Zhang Y, Han P, Wu N et al (2011) Amelioration of lipid abnormalities by \u03b1-lipoic acid through antioxidative and anti-inflammatory effects. Obesity 19(8):1647\u20131653. https:\/\/doi.org\/10.1038\/oby.2011.121","journal-title":"Obesity"},{"key":"4173_CR78","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5850865","author":"N Baziar","year":"2020","unstructured":"Baziar N, Nasli-Esfahani E, Djafarian K et al (2020) The beneficial effects of alpha lipoic acid supplementation on Lp-PLA2 mass and its distribution between HDL and apoB-containing lipoproteins in type 2 diabetic patients: a randomized, double-blind, placebo-controlled trial. Oxidative Med Cell Longev. https:\/\/doi.org\/10.1155\/2020\/5850865","journal-title":"Oxidative Med Cell Longev"},{"issue":"6","key":"4173_CR79","doi-asserted-by":"publisher","first-page":"F686","DOI":"10.1152\/ajprenal.00148.2012","volume":"304","author":"JH Lee","year":"2013","unstructured":"Lee JH, Kim JH et al (2013) AMP-activated protein kinase inhibits TGF-\u03b2-, angiotensin II-, aldosterone-, high glucose-, and albumin-induced epithelial-mesenchymal transition. Am J Physiol-Ren Physiol 304(6):F686\u2013F697","journal-title":"Am J Physiol-Ren Physiol"},{"key":"4173_CR80","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1016\/j.biopha.2017.11.101","volume":"97","author":"N Gamad","year":"2018","unstructured":"Gamad N, Malik S, Suchal K, Vasisht S et al (2018) Metformin alleviates bleomycin-induced pulmonary fibrosis in rats: pharmacological effects and molecular mechanisms. Biomed Pharmacother 97:1544\u20131553","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"4173_CR81","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1093\/toxsci\/kfr266","volume":"125","author":"J Lu","year":"2012","unstructured":"Lu J, Jones AD, Harkema JR, Roth RA, Ganey PE (2012) Amiodarone exposure during modest inflammation induces idiosyncrasy-like liver injury in rats: role of tumor necrosis factor-alpha. Toxicol Sci 125(1):126\u2013133. https:\/\/doi.org\/10.1093\/toxsci\/kfr266","journal-title":"Toxicol Sci"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-021-04173-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-021-04173-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-021-04173-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T17:48:39Z","timestamp":1672076919000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-021-04173-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,10]]},"references-count":81,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["4173"],"URL":"https:\/\/doi.org\/10.1007\/s11010-021-04173-7","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,10]]},"assertion":[{"value":"7 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest to declare that are relevant to the content of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Animals care during the experiments was carried out in keeping with agreement of the Medical Ethical Committee, National Research Centre (NRC), Egypt (Approval number: 20-143). Basic housing requirements and regular inspection of facilities that mandate the control of pain and suffering during the experiment were conducted. Euthanasia was done rapidly and painlessly to be sure that the animals do not suffer at any stage of the experiment. Getting rid of the animals after termination was done rapidly by the aid of the Safety and Health Committee at NRC, Egypt.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}