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It participates in the regulation of various biological processes, as diverse as paracellular permeability, tight junction formation and maintenance, leukocyte transendothelial migration, epithelial-to-mesenchymal transition, angiogenesis, reovirus binding, and platelet activation. Dysregulation of F11R\/JAM-A may result in pathological consequences and disorders in normal cell function. A growing body of evidence points to its role in carcinogenesis and invasiveness, but its tissue-specific pro- or anti-tumorigenic role remains a debated issue. The following review focuses on the F11R\/JAM-A tissue-dependent manner in tumorigenesis and metastasis and also discusses the correlation between poor patient clinical outcomes and its aberrant expression. In the future, it will be required to clarify the signaling pathways that are activated or suppressed via the F11R\/JAM-A protein in various cancer types to understand its multiple roles in cancer progression and further use it as a novel direct target for cancer treatment.<\/jats:p>","DOI":"10.1007\/s11010-021-04259-2","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T04:06:27Z","timestamp":1631851587000},"page":"79-98","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["The F11 Receptor (F11R)\/Junctional Adhesion Molecule-A (JAM-A) (F11R\/JAM-A) in cancer progression"],"prefix":"10.1007","volume":"477","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4173-4417","authenticated-orcid":false,"given":"Kamila","family":"Czubak-Prowizor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Babinska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Swiatkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,17]]},"reference":[{"key":"4259_CR1","first-page":"197","volume":"20","author":"T Keiper","year":"2005","unstructured":"Keiper T, Santoso S, Nawroth PP, Orlova V, Chavakis T (2005) The role of junctional adhesion molecules in cell-cell interactions. 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