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Plasma FGF23 concentration early rises in kidney and cardiovascular diseases correlating with progression and outcome. Lactic acid is generated in anaerobic glycolysis. Lactic acidosis is the consequence of various physiological and pathological conditions and may be fatal. Since FGF23 production is stimulated by inflammation and lactic acid induces pro-inflammatory signaling, we investigated whether and how lactic acid influences FGF23. Experiments were performed in UMR106 osteoblast-like cells, <jats:italic>Fgf23<\/jats:italic> mRNA levels estimated from quantitative real-time polymerase chain reaction, and FGF23 protein determined by enzyme-linked immunosorbent assay. Lactic acid dose-dependently induced <jats:italic>Fgf23<\/jats:italic> gene expression and up-regulated FGF23 synthesis. Also, Na<jats:sup>+<\/jats:sup>-lactate as well as formic acid and acetic acid up-regulated <jats:italic>Fgf23<\/jats:italic>. The lactic acid effect was significantly attenuated by nuclear factor kappa-light-chain enhancer of activated B-cells (NF\u03baB) inhibitors wogonin and withaferin A. Lactic acid induces FGF23 production, an effect at least in part mediated by NF\u03baB. Lactic acidosis may, therefore, be paralleled by a surge in plasma FGF23.<\/jats:p>","DOI":"10.1007\/s11010-021-04287-y","type":"journal-article","created":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T10:02:53Z","timestamp":1635933773000},"page":"363-370","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Lactic acid induces fibroblast growth factor 23 (FGF23) production in UMR106 osteoblast-like cells"],"prefix":"10.1007","volume":"477","author":[{"given":"Jana","family":"Alber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2074-4827","authenticated-orcid":false,"given":"Michael","family":"F\u00f6ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,3]]},"reference":[{"key":"4287_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/s41581-019-0189-5","volume":"16","author":"D Edmonston","year":"2020","unstructured":"Edmonston D, Wolf M (2020) FGF23 at the crossroads of phosphate, iron economy and erythropoiesis. 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