{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:37:44Z","timestamp":1792532264235,"version":"4.5.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T00:00:00Z","timestamp":1642636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T00:00:00Z","timestamp":1642636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1007\/s11010-021-04332-w","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T19:03:46Z","timestamp":1642619026000},"page":"793-803","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Quercetin and vitamin E ameliorate cardio-apoptotic risks in diabetic rats"],"prefix":"10.1007","volume":"477","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5726-319X","authenticated-orcid":false,"given":"Oluwatoyin O.","family":"Ojo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifedayo M.","family":"Obaidu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwatosin C.","family":"Obigade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olufunso O.","family":"Olorunsogo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,20]]},"reference":[{"key":"4332_CR1","first-page":"131","volume":"20","author":"WA Ojieabu","year":"2017","unstructured":"Ojieabu WA, Odusan O, Ojieabu NI, Oku LM (2017) Evaluation of prevalence of micro- and macrovascular complications among elderly type 2 diabetes patients in a health facility. Afr J Biomed Res 20:131\u2013135","journal-title":"Afr J Biomed Res"},{"key":"4332_CR2","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1007\/s00125-015-3827-x","volume":"59","author":"MV Cannon","year":"2016","unstructured":"Cannon MV, Sillje HHW, Sijbesma JWA et al (2016) LXR\u03b1 improves myocardial glucose and reduces cardiac hypertrophy in a mouse model of obesity-induced type 2 diabetes. Diabetologia 59:634\u2013643","journal-title":"Diabetologia"},{"key":"4332_CR3","doi-asserted-by":"publisher","first-page":"2422","DOI":"10.1007\/s00125-018-4696-x","volume":"61","author":"VK Lee","year":"2018","unstructured":"Lee VK, Hosking BM, Holeniewka J et al (2018) BTBR ob\/ob mouse model of type 2 diabetes exhibits early loss of retinal function and retial inflammation followed by late vascular changes. Diabetologia 61:2422\u20132432","journal-title":"Diabetologia"},{"key":"4332_CR4","first-page":"1","volume":"9","author":"Y Zhao","year":"2019","unstructured":"Zhao Y, Wenting Z, Jia Q et al (2019) High dose of vitamin E attenuates diabetic nephropathy via alleviation of autophagic stress. Front physiol 9:1\u201313","journal-title":"Front physiol"},{"key":"4332_CR5","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/s41419-017-0135-z","volume":"9","author":"CMO Volpe","year":"2018","unstructured":"Volpe CMO, Villar-Delfino PH, dos Anjos PMF et al (2018) Cellular death, reactive oxygen species (ROS) and diabetic complications. Cell Death Dis 9:119. https:\/\/doi.org\/10.1038\/s41419-017-0135-z","journal-title":"Cell Death Dis"},{"issue":"4","key":"4332_CR6","doi-asserted-by":"publisher","first-page":"546","DOI":"10.4103\/2230-8210.183480","volume":"20","author":"A Chawla","year":"2016","unstructured":"Chawla A, Chawla R, Jaggi S (2016) Microvascular and macrovascular complications in diabetes mellitus: distinct or continuum? Indian J Endocr Metab 20(4):546","journal-title":"Indian J Endocr Metab"},{"issue":"3","key":"4332_CR7","first-page":"546","volume":"10","author":"J Kasznicki","year":"2013","unstructured":"Kasznicki J, Drzewoski J (2013) Heart failure in the diabetic population-pathophysiology, diagnosis and management. Arch Med Sci 10(3):546\u2013556","journal-title":"Arch Med Sci"},{"issue":"7","key":"4332_CR8","doi-asserted-by":"publisher","first-page":"299","DOI":"10.4070\/kcj.2010.40.7.299","volume":"J40","author":"NH Kim","year":"2010","unstructured":"Kim NH, Kang PM (2010) Apoptosis in cardiovascular diseases: mechanism and clinical implications. Korean Circ J40(7):299\u2013305. https:\/\/doi.org\/10.4070\/kcj.2010.40.7.299","journal-title":"Korean Circ"},{"issue":"1","key":"4332_CR9","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s12967-017-1191-y","volume":"15","author":"E Teringova","year":"2017","unstructured":"Teringova E, Tousek P (2017) Apoptosis in ischemic heart disease. J Trans Med 15(1):87. https:\/\/doi.org\/10.1186\/s12967-017-1191-y","journal-title":"J Trans Med"},{"key":"4332_CR10","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1152\/phyrev.00013.2006","volume":"87","author":"G Kroemer","year":"2007","unstructured":"Kroemer G, Galluzzi L, Brenner C (2007) Mitochondrial membrane permeabilization in cell death. Physiol Rev 87:99\u2013163. https:\/\/doi.org\/10.1152\/phyrev.00013.2006","journal-title":"Physiol Rev"},{"key":"4332_CR11","doi-asserted-by":"publisher","first-page":"12","DOI":"10.4103\/ijcpc.ijcpc_1_19","volume":"3","author":"NA Riswana","year":"2019","unstructured":"Riswana NA, Bhuvaneshwari P (2019) Apoptotic cell death in heart failure associated with diabetes. Int J Clinicopathol Correl 3:12\u201318","journal-title":"Int J Clinicopathol Correl"},{"issue":"2","key":"4332_CR12","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.cmet.2014.12.001","volume":"21","author":"JQ Kwong","year":"2015","unstructured":"Kwong JQ, Molkentin JD (2015) Physiological and pathological roles of the mitochondrial permeability transition pore in the heart. Cell Metab 21(2):206\u2013214. https:\/\/doi.org\/10.1016\/j.cmet.2014.12.001","journal-title":"Cell Metab"},{"key":"4332_CR13","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.2147\/JIR.S275595","volume":"13","author":"J Checa","year":"2020","unstructured":"Checa J, Aran JM (2020) Reactive oxygen species: drivers of physiological and pathological processes. J Inflamm Res 13:1057\u20131073","journal-title":"J Inflamm Res"},{"key":"4332_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-019-0355-7","volume":"51","author":"JN Peoples","year":"2019","unstructured":"Peoples JN, Saraf A, Ghazal N et al (2019) Mitochondrial dysfunction and oxidative stress in heart disease. Exp Mol Med 51:1\u201313. https:\/\/doi.org\/10.1038\/s12276-019-0355-7","journal-title":"Exp Mol Med"},{"key":"4332_CR15","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6626484","author":"AC Kent","year":"2021","unstructured":"Kent AC, El Baradie KBY, Hamrick MW (2021) Targeting the mitochondrial permeability transition pore to prevent age-associated cell damage and neurodegeneration. Oxid Med Cell Longev. https:\/\/doi.org\/10.1155\/2021\/6626484","journal-title":"Oxid Med Cell Longev"},{"issue":"2","key":"4332_CR16","doi-asserted-by":"publisher","first-page":"529","DOI":"10.2337\/db15-1274","volume":"66","author":"J Gu","year":"2017","unstructured":"Gu J, Chen Y, Wu H et al (2017) Metallothionein is downstream of Nrf 2 and partially mediates sulforaphane prevention of diabetic cardiomyopathy. Diabetes 66(2):529\u2013542. https:\/\/doi.org\/10.2337\/db15-1274","journal-title":"Diabetes"},{"key":"4332_CR17","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s12872-015-0076-3","volume":"15","author":"C Liu","year":"2015","unstructured":"Liu C, Lu XZ, Shen MZ et al (2015) N-acetyl cysteine improves the cardiac function: possible role of fibrosis inhibition. BMC Cardiovasc Disord 15:84. https:\/\/doi.org\/10.1186\/s12872-015-0076-3","journal-title":"BMC Cardiovasc Disord"},{"key":"4332_CR18","doi-asserted-by":"publisher","first-page":"e67009","DOI":"10.1371\/journal.pone.0067009","volume":"7","author":"S Kumar","year":"2013","unstructured":"Kumar S, Prasad S, Sitasawad SL (2013) Multiple antioxidants improve cardiaccomplications and inhibit cardiac cell death in steptozocin-induced diabetic rats. PLoS ONE 7:e67009","journal-title":"PLoS ONE"},{"key":"4332_CR19","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/B978-0-12-394309-5.00006-7","volume":"298","author":"T Kalogeris","year":"2012","unstructured":"Kalogeris T, Baines CP, Krenz M et al (2012) Cell biology of ischemia\/reperfusion injury. Int Rev Cell Mol Biol 298:229\u2013317. https:\/\/doi.org\/10.1016\/B978-0-12-394309-5.00006-7","journal-title":"Int Rev Cell Mol Biol"},{"key":"4332_CR20","first-page":"H633","volume":"298","author":"CL Williamson","year":"2010","unstructured":"Williamson CL, Dabkowski ER, Baseler WA et al (2010) Enhanced apoptotic propensity in diabetic cardiac mitochondria: influence of subcellular spatial location. Am J Physiol 298:H633\u2013H642","journal-title":"Am J Physiol"},{"key":"4332_CR21","doi-asserted-by":"publisher","first-page":"H118","DOI":"10.1152\/ajpcell.00268.2010","volume":"300","author":"EJ Anderson","year":"2011","unstructured":"Anderson EJ, Rodriguez E, Anderson CA et al (2011) Increased propensity for cell death in diabetic human heart is mediated by mitochondrial-dependent pathways. Am J Physiol 300:H118\u2013H124","journal-title":"Am J Physiol"},{"key":"4332_CR22","doi-asserted-by":"publisher","first-page":"10580","DOI":"10.1073\/pnas.1401591111","volume":"111","author":"KN Alvian","year":"2014","unstructured":"Alvian KN, Beutner G, Lazrove E et al (2014) An uncoupling channel within the c-subunit ring of the F1F0-ATP synthase is the mitochondrial permeability transition pore. Proc Natl Acad Sci USA 111:10580\u201310585","journal-title":"Proc Natl Acad Sci USA"},{"key":"4332_CR23","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2014.96","author":"M Bonora","year":"2014","unstructured":"Bonora M, Wieckowski MR, Chinopoulos C et al (2014) Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition. Oncogene. https:\/\/doi.org\/10.1038\/onc.2014.96","journal-title":"Oncogene"},{"key":"4332_CR24","doi-asserted-by":"publisher","DOI":"10.1007\/s10989-019-09950-z","author":"OO Ojo","year":"2019","unstructured":"Ojo OO, Rotimi S, Adegbite OS et al (2019) BrideliaferrugineaInhibit rat heart and liver mitochondrial membrane permeability transition pore opening following myocardial infarction. Int J Pept Res Ther. https:\/\/doi.org\/10.1007\/s10989-019-09950-z","journal-title":"Int J Pept Res Ther"},{"key":"4332_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000103747","volume":"20","author":"S Javadov","year":"2007","unstructured":"Javadov S, Karmazyn M (2007) Mitochondrial permeability as an endpoint to initiate cell death and as a putative target for cardioprotection. Cell Physiol Biochem 20:1\u201322","journal-title":"Cell Physiol Biochem"},{"key":"4332_CR26","first-page":"460","volume":"504","author":"OO Daniel","year":"2018","unstructured":"Daniel OO, Adeoye AO, Ojowu J et al (2018) Inhibition of liver mitochondrial membrane permeability transition pore opening by quercetin and vitamin E in streptozotocin-induced diabetic rats. BBRC 504:460\u2013469","journal-title":"BBRC"},{"issue":"1","key":"4332_CR27","first-page":"157","volume":"78","author":"A Mahipa","year":"2016","unstructured":"Mahipa A, Klapman J, Vignesh S, Yang CS, Neuger A, Chen D et al (2016) Pharmacokinetics and safety of vitamin E \u03b4-tocotrienol after single and multiple doses in healthy subjects with measurement of vitamin E metabolites. Cancer ChemotherPharmacol 78(1):157\u2013165","journal-title":"Cancer ChemotherPharmacol"},{"issue":"3","key":"4332_CR28","doi-asserted-by":"publisher","first-page":"374","DOI":"10.3390\/foods9030374","volume":"9","author":"GE Batiha","year":"2020","unstructured":"Batiha GE, Beshbishy AM, Ikram M, Mulla ZS, Abd El-Hack ME, Taha AE et al (2020) The pharmacological activity, biochemical properties and pharmacokinetics of the major natural polyphenolic flavonoid: quercetin. Foods 9(3):374. https:\/\/doi.org\/10.3390\/foods9030374","journal-title":"Foods"},{"issue":"9","key":"4332_CR29","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1248\/bpb.33.1534","volume":"33","author":"KMMB Carvalho","year":"2010","unstructured":"Carvalho KMMB, Morais TC, de Melo TS et al (2010) The natural flavonoid quercetin ameliorates cerulin-induced acute pancreatitis in mice. Biol Pharm Bull 33(9):1534\u20131539","journal-title":"Biol Pharm Bull"},{"key":"4332_CR30","doi-asserted-by":"publisher","first-page":"e95008","DOI":"10.1371\/journal.pone0095008","volume":"4","author":"R Xu","year":"2014","unstructured":"Xu R, Zhang S, Tao A et al (2014) Influence of vitamin supplementation on glycaemic control: a meta-analysis of randomized controlled trials. PLoS ONE 4:e95008. https:\/\/doi.org\/10.1371\/journal.pone0095008","journal-title":"PLoS ONE"},{"issue":"2","key":"4332_CR31","first-page":"96","volume":"4","author":"G Saravanan","year":"2005","unstructured":"Saravanan G, Leelavinothan P (2005) Effect of SyzygiumCumini bark on blood glucose, plasma, insulin and C-peptide in streptozotocin induced diabetic rats. Int J Endocrinol Metab 4(2):96\u2013105","journal-title":"Int J Endocrinol Metab"},{"key":"4332_CR32","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1016\/j.phymed.2014.09.006","volume":"21","author":"OR Ayepola","year":"2014","unstructured":"Ayepola OR, Cerf ME, Brooks NL et al (2014) Kolaviron, a biflavonoid complex of Garcinia kola seeds modulates apoptosis by suppressing oxidative stress and inflammation in diabetes-induced nephrotoxic rats. Phytomedicine 21:1785\u20131793","journal-title":"Phytomedicine"},{"key":"4332_CR33","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.abb.2015.08.008","volume":"583","author":"C Gardic","year":"2015","unstructured":"Gardic C, Bauerova K, Stringa B et al (2015) Quercetin reduced-inflammation and increased antioxidant defense in rat adjuvant arthritis. Arch Biochem Biophys 583:150\u2013157","journal-title":"Arch Biochem Biophys"},{"issue":"3","key":"4332_CR34","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.taap.2014.12.003","volume":"282","author":"K Rashid","year":"2015","unstructured":"Rashid K, Sil PC (2015) Curcumin enhances recovery of pancreatic islets from cellular stress induced inflammation and apoptosis in diabetic rats. Toxicol Appl Pharmacol 282(3):297\u2013310","journal-title":"Toxicol Appl Pharmacol"},{"issue":"10","key":"4332_CR35","doi-asserted-by":"publisher","first-page":"3178","DOI":"10.1093\/jn\/131.10.3178","volume":"132","author":"KG Calfee-Mason","year":"2002","unstructured":"Calfee-Mason KG, Spear BT, Glauert HP (2002) Vitamin E inhibits NF-kappa B in rats administered the hepatic tumor promoter, phenobarbital. J Nutr 132(10):3178\u20133185","journal-title":"J Nutr"},{"key":"4332_CR36","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/j.biopha.2016.12.044","volume":"86","author":"J Roslan","year":"2017","unstructured":"Roslan J, Giribabu N, Karim K et al (2017) Quercetin ameliorates oxidative stress, inflammation and apoptosis in the heart of streptozotocin-nicotinamide-induced adult male diabetic rats. Biomed Pharmacother 86:570\u2013582","journal-title":"Biomed Pharmacother"},{"key":"4332_CR37","doi-asserted-by":"publisher","DOI":"10.1111\/and.14185","author":"OO Ojo","year":"2021","unstructured":"Ojo OO, Olorunsogo OO (2021) Quercetin and vitamin E attenuate diabetes-induced testicular anomaly in Wistar rats via the mitochondrial-mediated apoptotic pathway. Andrologia. https:\/\/doi.org\/10.1111\/and.14185","journal-title":"Andrologia"},{"key":"4332_CR38","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/0076-6879(79)55006-X","volume":"55","author":"L Mela","year":"1979","unstructured":"Mela L, Seitz S (1979) Isolation of mitochondria with emphasis on heart mitochondria from small amounts of tissue. Methods Enzymol 55:39\u201346. https:\/\/doi.org\/10.1016\/0076-6879(79)55006-X","journal-title":"Methods Enzymol"},{"issue":"3","key":"4332_CR39","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.exger.2006.10.003","volume":"42","author":"AA Sanz","year":"2007","unstructured":"Sanz AA, Hiona GC, Kujoth AY et al (2007) Evaluation of gender differences on mitochondrial bioenergetics and apoptosis in mice. Exp Gerontol 42(3):173\u2013182. https:\/\/doi.org\/10.1016\/j.exger.2006.10.003","journal-title":"Exp Gerontol"},{"issue":"3","key":"4332_CR40","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/0014-5793(92)81217-A","volume":"313","author":"RG Lapidus","year":"1993","unstructured":"Lapidus RG, Sokolove PM (1993) Inhibition by spermine of the inner membrane permeability transition of isolated rat heart mitochondria. FEBS Lett 313(3):314\u2013318","journal-title":"FEBS Lett"},{"issue":"8","key":"4332_CR41","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1055\/s-2000-9773","volume":"66","author":"G Ruberto","year":"2000","unstructured":"Ruberto G, Baratta MT, Deans SG et al (2000) Antioxidant and antimicrobial activity of foeniculum vulgare and Crithmum maritimum essential oils. Planta Med 66(8):687\u2013693","journal-title":"Planta Med"},{"issue":"1","key":"4332_CR42","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL et al (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193(1):265\u2013275","journal-title":"J Biol Chem"},{"issue":"3","key":"4332_CR43","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1124\/jpet.109.153213","volume":"330","author":"S Javadov","year":"2009","unstructured":"Javadov S, Karmazyn M, Escobales N (2009) Mitochondrial permeability transition pore opening as a promising therapeutic target in cardiac diseases. J Pharmacol Exp Ther 330(3):670\u2013678","journal-title":"J Pharmacol Exp Ther"},{"key":"4332_CR44","first-page":"1402","volume":"1789","author":"AP Halestrap","year":"2009","unstructured":"Halestrap AP, Pasdios P (2009) The role of the mitochondrial permeability transition pore in heart disease. Biochem Biophys Acta 1789:1402\u20131415","journal-title":"Biochem Biophys Acta"},{"key":"4332_CR45","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7584691","author":"J Li","year":"2017","unstructured":"Li J, Yu S, Ying J et al (2017) Resvaratrol prevents ROS-induced apoptosis in high glucose-treated retinal capillary endothelial cells via the activation of AMPK\/Sirt 1\/PGC-1\u03b1 pathway. Oxid Med Cell Longev. https:\/\/doi.org\/10.1155\/2017\/7584691","journal-title":"Oxid Med Cell Longev"},{"key":"4332_CR46","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.bbadis.2015.12.022","volume":"1862","author":"K Takemoto","year":"2016","unstructured":"Takemoto K, Doi W, Noriyoshi M (2016) Protective effect of vitamin E against alloxan-induced mouse hyperglycemia. Biochim Biophys Acta 1862:647\u2013650","journal-title":"Biochim Biophys Acta"},{"issue":"336","key":"4332_CR47","first-page":"1","volume":"8","author":"R Dhanya","year":"2017","unstructured":"Dhanya R, Arya AD, Nisha P (2017) Quercetin, a lead compound against type 2 diabetes ameliorate glucose uptake via AMPK pathway in skeletal muscle cell line. Frontiers in Pharmcol 8(336):1\u20139","journal-title":"Frontiers in Pharmcol"},{"issue":"4","key":"4332_CR48","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1590\/S1516-89132012000400007","volume":"55","author":"DAT Ameida","year":"2012","unstructured":"Ameida DAT, Braga CP, Novelli ELB et al (2012) Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidants vitamin. Braz Arch Biol Technol 55(4):527\u2013536","journal-title":"Braz Arch Biol Technol"},{"key":"4332_CR49","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/j.yjmcc.2012.02.009","volume":"52","author":"RC Sloan","year":"2012","unstructured":"Sloan RC, Moukdar F, Frasier CR et al (2012) Mitochondrial permeability transition in the diabetic heart: contributions of thiol redox state and mitochondrial calcium to augmented reperfusion injury. J Mol Cell Cardiol 52:1009\u20131018","journal-title":"J Mol Cell Cardiol"},{"key":"4332_CR50","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1186\/s40200-014-0106-1","volume":"13","author":"M Najafi","year":"2014","unstructured":"Najafi M, Farajnia S, Mohammadi M et al (2014) Inhibition of mitochondrial permeability transition pore restores the cardioprotection by postconditioning in diabetic hearts. J Diabetes Metab Disord 13:106","journal-title":"J Diabetes Metab Disord"},{"issue":"9","key":"4332_CR51","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1161\/CIRCRESAHA.110.223545","volume":"107","author":"F Giacco","year":"2010","unstructured":"Giacco F, Brownlee M (2010) Oxidative stress and diabetic complications. Circ Res 107(9):1058\u20131070. https:\/\/doi.org\/10.1161\/CIRCRESAHA.110.223545","journal-title":"Circ Res"},{"key":"4332_CR52","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8386065","author":"MN Sarian","year":"2017","unstructured":"Sarian MN, Ahmed QU, So\u2019ad SZM et al (2017) Antioxidant and antidiabetic effects of flavonoids: a structure-activity relationship based study. Biomed Res Int. https:\/\/doi.org\/10.1155\/2017\/8386065","journal-title":"Biomed Res Int"},{"key":"4332_CR53","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1016\/j.drudis.2008.07.004","volume":"13","author":"AL Harvey","year":"2008","unstructured":"Harvey AL (2008) Natural products in discovery. Drug Discov Today 13:894\u2013901","journal-title":"Drug Discov Today"},{"key":"4332_CR54","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s40200-015-0184-8","volume":"14","author":"O Tabatabaei-Malazy","year":"2015","unstructured":"Tabatabaei-Malazy O, Larijani B, Abdollahi M (2015) Targeting metabolic disorders by natural products. J Diabetes Metab Disord 14:57","journal-title":"J Diabetes Metab Disord"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-021-04332-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-021-04332-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-021-04332-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T23:37:14Z","timestamp":1645227434000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-021-04332-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,20]]},"references-count":54,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["4332"],"URL":"https:\/\/doi.org\/10.1007\/s11010-021-04332-w","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-772041\/v1","asserted-by":"object"}]},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,20]]},"assertion":[{"value":"31 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed using experimental animals were in accordance with the ethical standards of the procedures of the University of Ibadan Ethics Committee, Ibadan, Nigeria.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}