{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T07:18:02Z","timestamp":1769152682027,"version":"3.49.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T00:00:00Z","timestamp":1644537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T00:00:00Z","timestamp":1644537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002790","name":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2016-04051"],"award-info":[{"award-number":["RGPIN-2016-04051"]}],"id":[{"id":"10.13039\/501100002790","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004411","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","award":["G-18-0022098"],"award-info":[{"award-number":["G-18-0022098"]}],"id":[{"id":"10.13039\/100004411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1007\/s11010-022-04386-4","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T05:06:04Z","timestamp":1644555964000},"page":"1393-1403","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["H2S protects from oxidative stress-driven ACE2 expression and cardiac aging"],"prefix":"10.1007","volume":"477","author":[{"given":"Kalem","family":"Barrow","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuehong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruihuan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiechun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3575-7786","authenticated-orcid":false,"given":"Guangdong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,2,11]]},"reference":[{"key":"4386_CR1","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1002\/path.5471","volume":"251","author":"AR Bourgonje","year":"2020","unstructured":"Bourgonje AR, Abdulle AE, Timens W, Hillebrands JL, Navis GJ, Gordijn SJ, Bolling MC, Dijkstra G, Voors AA, van der Voort OAD, Mulder DJ, van Goor H (2020) Angiotensin-converting enzyme 2 (ACE2), SARS-CoV-2 and the pathophysiology of coronavirus disease 2019 (COVID-19). J Pathol 251:228\u2013248. https:\/\/doi.org\/10.1002\/path.5471","journal-title":"J Pathol"},{"key":"4386_CR2","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1177\/1753944715597623","volume":"9","author":"E Mendoza-Torres","year":"2015","unstructured":"Mendoza-Torres E, Oyarz\u00fan A, Mondaca-Ruff D, Azocar A, Castro PF, Jalil JE, Chiong M, Lavandero S, Ocaranza MP (2015) ACE2 and vasoactive peptides: novel players in cardiovascular\/renal remodeling and hypertension. Ther Adv Cardiovasc Dis 9:217\u2013237. https:\/\/doi.org\/10.1177\/1753944715597623","journal-title":"Ther Adv Cardiovasc Dis"},{"issue":"1","key":"4386_CR3","doi-asserted-by":"publisher","first-page":"19","DOI":"10.2337\/dbi15-0014","volume":"65","author":"RM Touyz","year":"2016","unstructured":"Touyz RM (2016) Protecting the heart in obesity: role of ACE2 and its partners. Diabetes 65(1):19\u201321. https:\/\/doi.org\/10.2337\/dbi15-0014","journal-title":"Diabetes"},{"key":"4386_CR4","doi-asserted-by":"publisher","first-page":"2141","DOI":"10.1016\/j.peptides.2011.09.010","volume":"32","author":"AND Cat","year":"2011","unstructured":"Cat AND, Touyz RM (2011) A new look at the renin-angiotensin system\u2013focusing on the vascular system. Peptides 32:2141\u20132150. https:\/\/doi.org\/10.1016\/j.peptides.2011.09.010","journal-title":"Peptides"},{"key":"4386_CR5","doi-asserted-by":"publisher","first-page":"85","DOI":"10.2337\/db15-0399","volume":"65","author":"VB Patel","year":"2016","unstructured":"Patel VB, Mori J, McLean BA, Basu R, Das SK, Ramprasath T, Parajuli N, Penninger JM, Grant MB, Lopaschuk GD, Oudit GY (2016) ACE2 deficiency worsens epicardial adipose tissue inflammation and cardiac dysfunction in response to diet-induced obesity. Diabetes 65:85\u201395. https:\/\/doi.org\/10.2337\/db15-0399","journal-title":"Diabetes"},{"key":"4386_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2020.108142","volume":"162","author":"A Hussain","year":"2020","unstructured":"Hussain A, Bhowmik B, do Vale Moreira NC (2020) COVID-19 and diabetes: knowledge in progress. Diabetes Res Clin Pract 162:108142. https:\/\/doi.org\/10.1016\/j.diabres.2020.108142","journal-title":"Diabetes Res Clin Pract"},{"key":"4386_CR7","doi-asserted-by":"publisher","first-page":"563","DOI":"10.3390\/ijms18030563","volume":"18","author":"H Roca-Ho","year":"2017","unstructured":"Roca-Ho H, Riera M, Palau V, Pascual J, Soler MJ (2017) Characterization of ACE and ACE2 expression within different organs of the NOD mouse. Int J Mol Sci 18:563. https:\/\/doi.org\/10.3390\/ijms18030563","journal-title":"Int J Mol Sci"},{"key":"4386_CR8","doi-asserted-by":"publisher","first-page":"2132","DOI":"10.2337\/db06-0033","volume":"55","author":"J Wysocki","year":"2006","unstructured":"Wysocki J, Ye M, Soler MJ, Gurley SB, Xiao HD, Bernstein KE, Coffman TM, Chen S, Batlle D (2006) ACE and ACE2 activity in diabetic mice. Diabetes 55:2132\u20132139. https:\/\/doi.org\/10.2337\/db06-0033","journal-title":"Diabetes"},{"key":"4386_CR9","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.2337\/dc20-0643","volume":"43","author":"S Rao","year":"2020","unstructured":"Rao S, Lau A, So HC (2020) Exploring diseases\/traits and blood proteins causally related to expression of ACE2, the putative receptor of SARS-CoV-2: a mendelian randomization analysis highlights tentative relevance of diabetes-related traits. Diabetes Care 43:1416\u20131426. https:\/\/doi.org\/10.2337\/dc20-0643","journal-title":"Diabetes Care"},{"key":"4386_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s42399-020-00363-4","volume":"2020","author":"A Sanyaolu","year":"2020","unstructured":"Sanyaolu A, Okorie C, Marinkovic A, Patidar R, Younis K, Desai P, Hosein Z, Padda I, Mangat J, Altaf M (2020) Comorbidity and its impact on patients with COVID-19. SN Compr Clin Med 2020:1\u20138. https:\/\/doi.org\/10.1007\/s42399-020-00363-4","journal-title":"SN Compr Clin Med"},{"key":"4386_CR11","doi-asserted-by":"publisher","first-page":"4825","DOI":"10.1111\/bph.15082","volume":"177","author":"K Sriram","year":"2020","unstructured":"Sriram K, Insel PA (2020) A hypothesis for pathobiology and treatment of COVID-19: the centrality of ACE1\/ACE2 imbalance. Br J Pharmacol 177:4825\u20134844. https:\/\/doi.org\/10.1111\/bph.15082","journal-title":"Br J Pharmacol"},{"key":"4386_CR12","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1126\/science.abb2762","volume":"367","author":"R Yan","year":"2020","unstructured":"Yan R, Zhang Y, Li Y, Xia L, Guo Y, Zhou Q (2020) Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science 367:1444\u20131448. https:\/\/doi.org\/10.1126\/science.abb2762","journal-title":"Science"},{"key":"4386_CR13","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1128\/JVI.01248-09","volume":"84","author":"I Glowacka","year":"2010","unstructured":"Glowacka I, Bertram S, Herzog P, Pfefferle S, Steffen I, Muench MO, Simmons G, Hofmann H, Kuri T, Weber F, Eichler J, Drosten C, P\u00f6hlmann S (2010) Differential downregulation of ACE2 by the spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus NL63. J Virol 84:1198\u20131205. https:\/\/doi.org\/10.1128\/JVI.01248-09","journal-title":"J Virol"},{"key":"4386_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30116-8","volume":"8","author":"L Fang","year":"2020","unstructured":"Fang L, Karakiulakis G, Roth M (2020) Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? Lancet Respir Med 8:e21. https:\/\/doi.org\/10.1016\/S2213-2600(20)30116-8","journal-title":"Lancet Respir Med"},{"key":"4386_CR15","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1111\/bph.12811","volume":"172","author":"I Andreadou","year":"2015","unstructured":"Andreadou I, Iliodromitis EK, Rassaf T, Schulz R, Papapetropoulos A, Ferdinandy P (2015) The role of gasotransmitters NO, H2S and CO in myocardial ischaemia\/reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning. Br J Pharmacol 172:1587\u20131606. https:\/\/doi.org\/10.1111\/bph.12811","journal-title":"Br J Pharmacol"},{"key":"4386_CR16","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1089\/ars.2014.6186","volume":"23","author":"S Li","year":"2015","unstructured":"Li S, Yang G (2015) Hydrogen sulfide maintains mitochondrial DNA replication via demethylation of TFAM. Antioxid Redox Signal 23:630\u2013642. https:\/\/doi.org\/10.1089\/ars.2014.6186","journal-title":"Antioxid Redox Signal"},{"key":"4386_CR17","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1126\/science.1162667","volume":"322","author":"G Yang","year":"2008","unstructured":"Yang G, Wu L, Jiang B, Yang W, Qi J, Cao K, Meng Q, Mustafa AK, Mu W, Zhang S, Snyder SH, Wang R (2008) H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase. Science 322:587\u2013590. https:\/\/doi.org\/10.1126\/science.1162667","journal-title":"Science"},{"key":"4386_CR18","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/357824","volume":"2015","author":"G Yang","year":"2015","unstructured":"Yang G, An SS, Ji Y, Zhang W, Pei Y (2015) Hydrogen sulfide signaling in oxidative stress and aging development. Oxid Med Cell Longev 2015:357824. https:\/\/doi.org\/10.1155\/2015\/357824","journal-title":"Oxid Med Cell Longev"},{"key":"4386_CR19","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/925167","volume":"2015","author":"Y Shen","year":"2015","unstructured":"Shen Y, Shen Z, Luo S, Guo W, Zhu YZ (2015) The Cardioprotective effects of hydrogen sulfide in heart diseases: from molecular mechanisms to therapeutic potential. Oxid Med Cell Longev 2015:925167. https:\/\/doi.org\/10.1155\/2015\/925167","journal-title":"Oxid Med Cell Longev"},{"key":"4386_CR20","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1097\/SHK.0000000000001562","volume":"54","author":"G Renieris","year":"2020","unstructured":"Renieris G, Katrini K, Damoulari C, Akinosoglou K, Psarrakis C, Kyriakopoulou M, Dimopoulos G, Lada M, Koufargyris P, Giamarellos-Bourboulis EJ (2020) Serum hydrogen sulfide and outcome association in pneumonia by the SARS-CoV-2 coronavirus. Shock 54:633\u2013637. https:\/\/doi.org\/10.1097\/SHK.0000000000001562","journal-title":"Shock"},{"key":"4386_CR21","doi-asserted-by":"publisher","first-page":"2523","DOI":"10.1161\/CIRCULATIONAHA.113.002208","volume":"127","author":"S Mani","year":"2013","unstructured":"Mani S, Li H, Untereiner A, Wu L, Yang G, Austin RC, Dickhout JG, Lhot\u00e1k \u0160, Meng QH, Wang R (2013) Decreased endogenous production of hydrogen sulfide accelerates atherosclerosis. Circulation 127:2523\u20132534. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.113.002208","journal-title":"Circulation"},{"key":"4386_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/13813455.2021.1976209","volume":"11","author":"R Yu","year":"2021","unstructured":"Yu R, Wang Y, Zhu J, Yang G (2021) H(2)S-mediated blockage of protein acetylation and oxidative stress attenuates lipid overload-induced cardiac senescence. Arch Physiol Biochem 11:1\u201314. https:\/\/doi.org\/10.1080\/13813455.2021.1976209","journal-title":"Arch Physiol Biochem"},{"key":"4386_CR23","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.taap.2018.07.029","volume":"356","author":"M Racine","year":"2018","unstructured":"Racine M, Fu M, Shuang T, Zhang Y, Pei Y, Wu L, Wang R, Yang G (2018) Reversal of Sp1 transactivation and TGFbeta1\/SMAD1 signaling by H(2)S prevent nickel-induced fibroblast activation. Toxicol Appl Pharmacol 356:25\u201335. https:\/\/doi.org\/10.1016\/j.taap.2018.07.029","journal-title":"Toxicol Appl Pharmacol"},{"key":"4386_CR24","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.1038\/nprot.2009.191","volume":"4","author":"F Debacq-Chainiaux","year":"2009","unstructured":"Debacq-Chainiaux F, Erusalimsky JD, Campisi J, Toussaint O (2009) Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo. Nat Protoc 4:1798\u20131806. https:\/\/doi.org\/10.1038\/nprot.2009.191","journal-title":"Nat Protoc"},{"key":"4386_CR25","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/s41586-020-2179-y","volume":"581","author":"J Shang","year":"2020","unstructured":"Shang J, Ye G, Shi K, Wan Y, Luo C, Aihara H, Geng Q, Auerbach A, Li F (2020) Structural basis of receptor recognition by SARS-CoV-2. Nature 581:221\u2013224. https:\/\/doi.org\/10.1038\/s41586-020-2179-y","journal-title":"Nature"},{"key":"4386_CR26","doi-asserted-by":"publisher","first-page":"6008","DOI":"10.1093\/emboj\/20.21.6008","volume":"20","author":"W Zhao","year":"2001","unstructured":"Zhao W, Zhang J, Lu Y, Wang R (2001) The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener. EMBO J 20:6008\u20136016. https:\/\/doi.org\/10.1093\/emboj\/20.21.6008","journal-title":"EMBO J"},{"key":"4386_CR27","doi-asserted-by":"publisher","first-page":"8841575","DOI":"10.1155\/2021\/8841575","volume":"2021","author":"H Zhang","year":"2021","unstructured":"Zhang H, Dai J, Tian D, Xiao L, Xue H, Guo Q, Zhang X, Teng X, Jin S, Wu Y (2021) Hydrogen sulfide restored the diurnal variation in cardiac function of aging mice. Oxid Med Cell Longev 2021:8841575. https:\/\/doi.org\/10.1155\/2021\/8841575","journal-title":"Oxid Med Cell Longev"},{"key":"4386_CR28","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.phrs.2013.04.011","volume":"74","author":"F Talaei","year":"2013","unstructured":"Talaei F, van Praag VM, Henning RH (2013) Hydrogen sulfide restores a normal morphological phenotype in Werner syndrome fibroblasts, attenuates oxidative damage and modulates mTOR pathway. Pharmacol Res 74:34\u201344. https:\/\/doi.org\/10.1016\/j.phrs.2013.04.011","journal-title":"Pharmacol Res"},{"key":"4386_CR29","doi-asserted-by":"publisher","first-page":"2166","DOI":"10.1016\/j.lfs.2005.09.038","volume":"78","author":"X Xie","year":"2006","unstructured":"Xie X, Chen J, Wang X, Zhang F, Liu Y (2006) Age- and gender-related difference of ACE2 expression in rat lung. Life Sci 78:2166\u20132171. https:\/\/doi.org\/10.1016\/j.lfs.2005.09.038","journal-title":"Life Sci"},{"key":"4386_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2021.112526","author":"Z Zheng","year":"2021","unstructured":"Zheng Z, Wang B, Lv X, Yao F, Gao H, Jin Z, Liu Y, Deng Y, Chen D, Ning X, Wang W, He J, Lin R (2021) Protective effect of SIRT6 on cholesterol crystal-induced endothelial dysfunction via regulating ACE2 expression. Exp Cell Res. https:\/\/doi.org\/10.1016\/j.yexcr.2021.112526","journal-title":"Exp Cell Res"},{"key":"4386_CR31","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.3389\/fphar.2020.01150","volume":"11","author":"Y Li","year":"2020","unstructured":"Li Y, Liu M, Song X, Zheng X, Yi J, Liu D, Wang S, Chu C, Yang J (2020) Exogenous hydrogen sulfide ameliorates diabetic mocardial fibrosis by inhibiting cell aging through SIRT6\/AMPK autophagy. Front Pharmacol 11:1150. https:\/\/doi.org\/10.3389\/fphar.2020.01150","journal-title":"Front Pharmacol"},{"key":"4386_CR32","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.019948","author":"F Rizvi","year":"2021","unstructured":"Rizvi F, Preston CC, Emelyanova L, Yousufuddin M, Viqar M, Dakwar O, Ross GR, Faustino RS, Holmuhamedov EL, Jahangir A (2021) Effects of aging on cardiac oxidative stress and transcriptional changes in pathways of reactive oxygen species generation and clearance. J Am Heart Assoc. https:\/\/doi.org\/10.1161\/JAHA.120.019948","journal-title":"J Am Heart Assoc"},{"key":"4386_CR33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077034","author":"R Dong","year":"2013","unstructured":"Dong R, Xu X, Li G, Feng W, Zhao G, Zhao J, Wang DW, Tu L (2013) Bradykinin inhibits oxidative stress-induced cardiomyocytes senescence via regulating redox state. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0077034","journal-title":"PLoS ONE"},{"key":"4386_CR34","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1248\/bpb.34.501","volume":"34","author":"K Oyama","year":"2011","unstructured":"Oyama K, Takahashi K, Sakurai K (2011) Hydrogen peroxide induces cell cycle arrest in cardiomyoblast H9c2 cells, which is related to hypertrophy. Biol Pharm Bull 34:501\u2013506. https:\/\/doi.org\/10.1248\/bpb.34.501","journal-title":"Biol Pharm Bull"},{"key":"4386_CR35","doi-asserted-by":"publisher","first-page":"280","DOI":"10.3389\/fendo.2020.00280","volume":"11","author":"X Tang","year":"2020","unstructured":"Tang X, Li PH, Chen HZ (2020) Cardiomyocyte senescence and cellular communications within myocardial microenvironments. Front Endocrinol (Lausanne) 11:280. https:\/\/doi.org\/10.3389\/fendo.2020.00280","journal-title":"Front Endocrinol (Lausanne)"},{"key":"4386_CR36","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1089\/ars.2012.4645","volume":"18","author":"G Yang","year":"2013","unstructured":"Yang G, Zhao K, Ju Y, Mani S, Cao Q, Puukila S, Khaper N, Wu L, Wang R (2013) Hydrogen sulfide protects against cellular senescence via S-sulfhydration of Keap1 and activation of Nrf2. Antioxid Redox Signal 18:1906\u20131919. https:\/\/doi.org\/10.1089\/ars.2012.4645","journal-title":"Antioxid Redox Signal"},{"key":"4386_CR37","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/256294","volume":"2012","author":"C Tikellis","year":"2012","unstructured":"Tikellis C, Thomas MC (2012) Angiotensin-converting enzyme 2 (ACE2) is a key modulator of the renin angiotensin system in health and disease. Int J Pept 2012:256294. https:\/\/doi.org\/10.1155\/2012\/256294","journal-title":"Int J Pept"},{"key":"4386_CR38","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1152\/physrev.00030.2020","volume":"101","author":"J Ren","year":"2021","unstructured":"Ren J, Wu NN, Wang S, Sowers JR, Zhang Y (2021) Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications. Physiol Rev 101:1745\u20131807. https:\/\/doi.org\/10.1152\/physrev.00030.2020","journal-title":"Physiol Rev"},{"key":"4386_CR39","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1161\/CIRCRESAHA.113.302095","volume":"113","author":"SC Kolwicz","year":"2013","unstructured":"Kolwicz SC, Purohit S, Tian R (2013) Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes. Circ Res 113:603\u2013616. https:\/\/doi.org\/10.1161\/CIRCRESAHA.113.302095","journal-title":"Circ Res"},{"key":"4386_CR40","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.555039","volume":"11","author":"S Al Heialy","year":"2020","unstructured":"Al Heialy S, Hachim MY, Senok A, Gaudet M, Abou Tayoun A, Hamoudi R, Alsheikh-Ali A, Hamid Q (2020) Regulation of angiotensin-converting enzyme 2 in obesity: implications for COVID-19. Front Physiol 11:555039. https:\/\/doi.org\/10.3389\/fphys.2020.555039","journal-title":"Front Physiol"},{"key":"4386_CR41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119511","volume":"10","author":"CY Tsai","year":"2015","unstructured":"Tsai CY, Peh MT, Feng W, Dymock BW, Moore PK (2015) Hydrogen sulfide promotes adipogenesis in 3T3L1 cells. PLoS ONE 10:e0119511. https:\/\/doi.org\/10.1371\/journal.pone.0119511","journal-title":"PLoS ONE"},{"key":"4386_CR42","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.3390\/ijms22041687","volume":"22","author":"Q Ding","year":"2021","unstructured":"Ding Q, Shults NV, Gychka SG, Harris BT, Suzuki YJ (2021) Protein expression of angiotensin-converting enzyme 2 (ACE2) is upregulated in brains with Alzheimer\u2019s disease. Int J Mol Sci 22:1687. https:\/\/doi.org\/10.3390\/ijms22041687","journal-title":"Int J Mol Sci"},{"key":"4386_CR43","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.540591","volume":"11","author":"X Liu","year":"2020","unstructured":"Liu X, Liu X, Li M, Zhang Y, Chen W, Zhang M, Zhang C, Zhang M (2020) Mechanical stretch induces smooth muscle cell dysfunction by regulating ACE2 via p38\/ATF3 and post-transcriptional regulation by miR-421. Front Physiol 11:540591. https:\/\/doi.org\/10.3389\/fphys.2020.540591","journal-title":"Front Physiol"},{"key":"4386_CR44","doi-asserted-by":"publisher","first-page":"5263","DOI":"10.3390\/ijms22105263","volume":"22","author":"NM Elemam","year":"2021","unstructured":"Elemam NM, Hasswan H, Aljaibeji H, Sulaiman N (2021) Circulating soluble ACE2 and upstream microRNA expressions in serum of type 2 diabetes mellitus patients. Int J Mol Sci 22:5263. https:\/\/doi.org\/10.3390\/ijms22105263","journal-title":"Int J Mol Sci"},{"key":"4386_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000492969","volume":"103","author":"L Ren","year":"2019","unstructured":"Ren L, Wang Q, Chen Y, Ma Y, Wang D (2019) Involvement of microRNA-133a in the protective effect of hydrogen sulfide against ischemia\/reperfusion-induced endoplasmic reticulum stress and cardiomyocyte apoptosis. Pharmacology 103:1\u20139. https:\/\/doi.org\/10.1159\/000492969","journal-title":"Pharmacology"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-022-04386-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-022-04386-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-022-04386-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T11:09:21Z","timestamp":1744196961000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-022-04386-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,11]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["4386"],"URL":"https:\/\/doi.org\/10.1007\/s11010-022-04386-4","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,11]]},"assertion":[{"value":"11 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}