{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T07:05:40Z","timestamp":1779174340190,"version":"3.51.4"},"reference-count":79,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:00:00Z","timestamp":1648166400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:00:00Z","timestamp":1648166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"the social development project of jiangsu provincial science and technology department","award":["BE2017627"],"award-info":[{"award-number":["BE2017627"]}]},{"name":"the high-end talent project of wuxi health committee, the youth project of wuxi health committee","award":["Q202038"],"award-info":[{"award-number":["Q202038"]}]},{"name":"the reserve top talent project of wuxi municipal health commission","award":["HB2020032"],"award-info":[{"award-number":["HB2020032"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s11010-022-04409-0","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T03:02:30Z","timestamp":1648177350000},"page":"1849-1863","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Quantitative proteomics analysis of human vitreous in rhegmatogenous retinal detachment associated with choroidal detachment by data-independent acquisition mass spectrometry"],"prefix":"10.1007","volume":"477","author":[{"given":"Shasha","family":"Luo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiyan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lufei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuechun","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinyan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1118-6176","authenticated-orcid":false,"given":"Zhifeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,3,25]]},"reference":[{"key":"4409_CR1","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/s12886-016-0319-9","volume":"16","author":"Y Yu","year":"2016","unstructured":"Yu Y, An M, Mo B, Yang Z, Liu W (2016) Risk factors for choroidal detachment following rhegmatogenous retinal detachment in a chinese population. BMC Ophthalmol 16:140. https:\/\/doi.org\/10.1186\/s12886-016-0319-9","journal-title":"BMC Ophthalmol"},{"key":"4409_CR2","first-page":"135","volume":"38","author":"J Zhu","year":"2002","unstructured":"Zhu J, Xu X, Zhang X (2002) Surgical therapeutic results of rhegmatogenous retinal detachment associated with choroidal detachment. Zhonghua Yan Ke Za Zhi 38:135\u2013139","journal-title":"Zhonghua Yan Ke Za Zhi"},{"key":"4409_CR3","first-page":"664","volume":"79","author":"WH Jarrett 2nd","year":"1981","unstructured":"Jarrett WH 2nd (1981) Rhematogenous retinal detachment complicated by severe intraocular inflammation, hypotony, and choroidal detachment. Trans Am Ophthalmol Soc 79:664\u2013683","journal-title":"Trans Am Ophthalmol Soc"},{"key":"4409_CR4","doi-asserted-by":"publisher","first-page":"2020","DOI":"10.1097\/IAE.0b013e3182561f7c","volume":"32","author":"Z Li","year":"2012","unstructured":"Li Z, Li Y, Huang X, yu Cai X, Chen X, Li S, Huang Y, Lu L (2012) Quantitative analysis of rhegmatogenous retinal detachment associated with choroidal detachment in Chinese using UBM. Retina 32:2020\u20132025","journal-title":"Retina"},{"key":"4409_CR5","first-page":"989","volume":"9","author":"Y-H Gu","year":"2016","unstructured":"Gu Y-H, Ke G-J, Wang L, Gu Q-H, Zhou E-L, Pan H-B, Wang S-Y (2016) Risk factors of rhegmatogenous retinal detachment associated with choroidal detachment in Chinese patients. Int J Ophthalmol 9:989","journal-title":"Int J Ophthalmol"},{"key":"4409_CR6","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1016\/j.ophtha.2013.01.056","volume":"120","author":"R Adelman","year":"2013","unstructured":"Adelman R, Parnes A, Sipperley J, Ducournau D (2013) European Vitreo-Retinal Society (EVRS) retinal detachment study group. Strategy for the management of complex retinal detachments. Ophthalmology 120:1809\u20131813. https:\/\/doi.org\/10.1016\/j.ophtha.2013.01.056","journal-title":"Ophthalmology"},{"key":"4409_CR7","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1097\/IAE.0b013e3182923463","volume":"34","author":"Y Wei","year":"2014","unstructured":"Wei Y, Wang N, Chen F, Wang H, Bi C, Zu Z, Yang X (2014) Vitrectomy combined with periocular\/intravitreal injection of steroids for rhegmatogenous retinal detachment associated with choroidal detachment. Retina 34:136\u2013141. https:\/\/doi.org\/10.1097\/IAE.0b013e3182923463","journal-title":"Retina"},{"key":"4409_CR8","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1001\/archopht.1974.03900060264003","volume":"91","author":"MH Seelenfreund","year":"1974","unstructured":"Seelenfreund MH, Kraushar MF, Schepens CL, Freilich DB (1974) Choroidal detachment associated with primary retinal detachment. Arch Ophthalmol 91:254\u2013258. https:\/\/doi.org\/10.1001\/archopht.1974.03900060264003","journal-title":"Arch Ophthalmol"},{"key":"4409_CR9","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1080\/14789450.2017.1322904","volume":"14","author":"JG Meyer","year":"2017","unstructured":"Meyer JG, Schilling B (2017) Clinical applications of quantitative proteomics using targeted and untargeted data-independent acquisition techniques. Expert Rev Proteomics 14:419\u2013429. https:\/\/doi.org\/10.1080\/14789450.2017.1322904","journal-title":"Expert Rev Proteomics"},{"issue":"O111","key":"4409_CR10","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.O111.016717","volume":"11","author":"LC Gillet","year":"2012","unstructured":"Gillet LC, Navarro P, Tate S, R\u00f6st H, Selevsek N, Reiter L, Bonner R, Aebersold R (2012) Targeted data extraction of the MS\/MS spectra generated by data-independent acquisition: a new concept for consistent and accurate proteome analysis. Mol Cell Proteomics 11(O111):016717. https:\/\/doi.org\/10.1074\/mcp.O111.016717","journal-title":"Mol Cell Proteomics"},{"key":"4409_CR11","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1002\/1878-0261.12642","volume":"14","author":"X Ku","year":"2020","unstructured":"Ku X, Sun Q, Zhu L, Gu Z, Han Y, Xu N, Meng C, Yang X, Yan W, Fang W (2020) Deciphering tissue-based proteome signatures revealed novel subtyping and prognostic markers for thymic epithelial tumors. Mol Oncol 14:721\u2013741. https:\/\/doi.org\/10.1002\/1878-0261.12642","journal-title":"Mol Oncol"},{"key":"4409_CR12","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17122052","author":"Z Wu","year":"2016","unstructured":"Wu Z, Ding N, Yu M, Wang K, Luo S, Zou W, Zhou Y, Yan B, Jiang Q (2016) Identification of potential biomarkers for rhegmatogenous retinal detachment associated with choroidal detachment by vitreous iTRAQ-based proteomic profiling. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms17122052","journal-title":"Int J Mol Sci"},{"key":"4409_CR13","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1016\/j.cmet.2020.04.011","volume":"31","author":"C Jian","year":"2020","unstructured":"Jian C, Fu J, Cheng X, Shen LJ, Ji YX, Wang X, Pan S, Tian H, Tian S, Liao R, Song K, Wang HP, Zhang X, Wang Y, Huang Z, She ZG, Zhang XJ, Zhu L, Li H (2020) Low-Dose Sorafenib Acts as a Mitochondrial Uncoupler and Ameliorates Nonalcoholic Steatohepatitis. Cell Metab 31:892-908.e11. https:\/\/doi.org\/10.1016\/j.cmet.2020.04.011","journal-title":"Cell Metab"},{"key":"4409_CR14","doi-asserted-by":"publisher","first-page":"D1211","DOI":"10.1093\/nar\/gky869","volume":"47","author":"J Ma","year":"2019","unstructured":"Ma J, Chen T, Wu S, Yang C, Bai M, Shu K, Li K, Zhang G, Jin Z, He F (2019) iProX: an integrated proteome resource. Nucleic Acids Res 47:D1211\u2013D1217","journal-title":"Nucleic Acids Res"},{"key":"4409_CR15","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13:2498\u20132504. https:\/\/doi.org\/10.1101\/gr.1239303","journal-title":"Genome Res"},{"key":"4409_CR16","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s13402-017-0315-y","volume":"40","author":"M Giulietti","year":"2017","unstructured":"Giulietti M, Occhipinti G, Principato G, Piva F (2017) Identification of candidate miRNA biomarkers for pancreatic ductal adenocarcinoma by weighted gene co-expression network analysis. Cell Oncol 40:181\u2013192. https:\/\/doi.org\/10.1007\/s13402-017-0315-y","journal-title":"Cell Oncol"},{"key":"4409_CR17","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1739444","author":"M Liu","year":"2020","unstructured":"Liu M, Pi H, Xi Y, Wang L, Tian L, Chen M, Xie J, Deng P, Zhang T, Zhou C, Liang Y, Zhang L, He M, Lu Y, Chen C, Yu Z, Zhou Z (2020) KIF5A-dependent axonal transport deficiency disrupts autophagic flux in trimethyltin chloride-induced neurotoxicity. Autophagy. https:\/\/doi.org\/10.1080\/15548627.2020.1739444","journal-title":"Autophagy"},{"key":"4409_CR18","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1093\/bioinformatics\/btq054","volume":"26","author":"B MacLean","year":"2010","unstructured":"MacLean B, Tomazela DM, Shulman N, Chambers M, Finney GL, Frewen B, Kern R, Tabb DL, Liebler DC, MacCoss MJ (2010) Skyline: an open source document editor for creating and analyzing targeted proteomics experiments. Bioinformatics 26:966\u2013968. https:\/\/doi.org\/10.1093\/bioinformatics\/btq054","journal-title":"Bioinformatics"},{"key":"4409_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2020.102036","volume":"126","author":"R Bansal","year":"2021","unstructured":"Bansal R, Khan MM, Dasari S, Verma I, Goodlett DR, Manes NP, Nita-Lazar A, Sharma SP, Kumar A, Singh N, Chakraborti A, Gupta V, Dogra MR, Ram J, Gupta A (2021) Proteomic profile of vitreous in patients with tubercular uveitis. Tuberculosis 126:102036. https:\/\/doi.org\/10.1016\/j.tube.2020.102036","journal-title":"Tuberculosis"},{"key":"4409_CR20","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1089\/jir.2019.0030","volume":"39","author":"Q Wei","year":"2019","unstructured":"Wei Q, Jiang C, Ye X, Huang X, Jin H, Xu G (2019) Vitreous proteomics provides new insights into antivascular endothelial growth factor therapy for pathologic myopia choroid neovascularization. J Interferon Cytokine Res 39:786\u2013796. https:\/\/doi.org\/10.1089\/jir.2019.0030","journal-title":"J Interferon Cytokine Res"},{"key":"4409_CR21","first-page":"417","volume":"21","author":"Y Dai","year":"2015","unstructured":"Dai Y, Wu Z, Sheng H, Zhang Z, Yu M, Zhang Q (2015) Identification of inflammatory mediators in patients with rhegmatogenous retinal detachment associated with choroidal detachment. Mol Vis 21:417\u2013427","journal-title":"Mol Vis"},{"key":"4409_CR22","first-page":"737","volume":"36","author":"SF Geller","year":"1995","unstructured":"Geller SF, Lewis GP, Anderson DH, Fisher SK (1995) Use of the MIB-1 antibody for detecting proliferating cells in the retina. Invest Ophthalmol Vis Sci 36:737\u2013744","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4409_CR23","doi-asserted-by":"publisher","first-page":"4256183","DOI":"10.1155\/2016\/4256183","volume":"2016","author":"S Takahashi","year":"2016","unstructured":"Takahashi S, Adachi K, Suzuki Y, Maeno A, Nakazawa M (2016) Profiles of inflammatory cytokines in the vitreous fluid from patients with rhegmatogenous retinal detachment and their correlations with clinical features. Biomed Res Int 2016:4256183. https:\/\/doi.org\/10.1155\/2016\/4256183","journal-title":"Biomed Res Int"},{"key":"4409_CR24","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/j.pupt.2013.01.008","volume":"26","author":"MR Dillingh","year":"2013","unstructured":"Dillingh MR, van den Blink B, Moerland M, van Dongen MG, Levi M, Kleinjan A, Wijsenbeek MS, Lupher ML Jr, Harper DM, Getsy JA, Hoogsteden HC, Burggraaf J (2013) Recombinant human serum amyloid P in healthy volunteers and patients with pulmonary fibrosis. Pulm Pharmacol Ther 26:672\u2013676. https:\/\/doi.org\/10.1016\/j.pupt.2013.01.008","journal-title":"Pulm Pharmacol Ther"},{"key":"4409_CR25","doi-asserted-by":"publisher","first-page":"e00218","DOI":"10.1128\/mBio.00218-19","volume":"10","author":"NE Behrens","year":"2019","unstructured":"Behrens NE, Lipke PN, Pilling D, Gomer RH, Klotz SA (2019) Serum Amyloid P component binds fungal surface amyloid and decreases human macrophage phagocytosis and secretion of inflammatory cytokines. MBio 10:e00218\u2013e00219. https:\/\/doi.org\/10.1128\/mBio.00218-19","journal-title":"MBio"},{"key":"4409_CR26","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.vph.2015.05.001","volume":"73","author":"G Vilahur","year":"2015","unstructured":"Vilahur G, Badimon L (2015) Biological actions of pentraxins. Vascul Pharmacol 73:38\u201344. https:\/\/doi.org\/10.1016\/j.vph.2015.05.001","journal-title":"Vascul Pharmacol"},{"key":"4409_CR27","doi-asserted-by":"publisher","first-page":"7619","DOI":"10.1073\/pnas.0902640106","volume":"106","author":"SE Kolstoe","year":"2009","unstructured":"Kolstoe SE, Ridha BH, Bellotti V, Wang N, Robinson CV, Crutch SJ, Keir G, Kukkastenvehmas R, Gallimore JR, Hutchinson WL, Hawkins PN, Wood SP, Rossor MN, Pepys MB (2009) Molecular dissection of Alzheimer,s disease neuropathology by depletion of serum amyloid P component. Proc Natl Acad Sci USA 106:7619\u20137623. https:\/\/doi.org\/10.1073\/pnas.0902640106","journal-title":"Proc Natl Acad Sci USA"},{"key":"4409_CR28","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s13105-015-0389-9","volume":"71","author":"Z Luo","year":"2015","unstructured":"Luo Z, Lei H, Sun Y, Liu X, Su DF (2015) Orosomucoid, an acute response protein with multiple modulating activities. J Physiol Biochem 71:329\u2013340. https:\/\/doi.org\/10.1007\/s13105-015-0389-9","journal-title":"J Physiol Biochem"},{"key":"4409_CR29","doi-asserted-by":"publisher","first-page":"2878","DOI":"10.1523\/jneurosci.2534-16.2017","volume":"37","author":"M Jo","year":"2017","unstructured":"Jo M, Kim J, Song G, Seo M, Hwang E, Suk K (2017) Astrocytic Orosomucoid-2 modulates microglial activation and neuroinflammation. J Neurosci 37:2878\u20132894. https:\/\/doi.org\/10.1523\/jneurosci.2534-16.2017","journal-title":"J Neurosci"},{"key":"4409_CR30","first-page":"107","volume":"25","author":"R Sabry","year":"2018","unstructured":"Sabry R, El-Madbouly A, Abozeid H, Hassan M (2018) Urinary Orosomucoid - 2 and soluble CD14 as potential biomarkers for assessment of disease activity in rheumatoid arthritis. Egypt J Immunol 25:107\u2013116","journal-title":"Egypt J Immunol"},{"key":"4409_CR31","doi-asserted-by":"publisher","first-page":"5706","DOI":"10.1167\/iovs.14-16338","volume":"56","author":"M Yu","year":"2015","unstructured":"Yu M, Wu Z, Zhang Z, Huang X, Zhang Q (2015) Metabolomic analysis of human vitreous in rhegmatogenous retinal detachment associated with choroidal detachment. Invest Ophthalmol Vis Sci 56:5706\u20135713. https:\/\/doi.org\/10.1167\/iovs.14-16338","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4409_CR32","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1042\/bj2710285","volume":"271","author":"MA Kerr","year":"1990","unstructured":"Kerr MA (1990) The structure and function of human IgA. Biochem J 271:285\u2013296. https:\/\/doi.org\/10.1042\/bj2710285","journal-title":"Biochem J"},{"key":"4409_CR33","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/nri3128","volume":"12","author":"M McHeyzer-Williams","year":"2011","unstructured":"McHeyzer-Williams M, Okitsu S, Wang N, McHeyzer-Williams L (2011) Molecular programming of B cell memory. Nat Rev Immunol 12:24\u201334. https:\/\/doi.org\/10.1038\/nri3128","journal-title":"Nat Rev Immunol"},{"key":"4409_CR34","doi-asserted-by":"publisher","first-page":"S41","DOI":"10.1016\/j.jaci.2009.09.046","volume":"125","author":"HW Schroeder Jr","year":"2010","unstructured":"Schroeder HW Jr, Cavacini L (2010) Structure and function of immunoglobulins. J Allergy Clin Immunol 125:S41-52. https:\/\/doi.org\/10.1016\/j.jaci.2009.09.046","journal-title":"J Allergy Clin Immunol"},{"key":"4409_CR35","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/s0002-9394(14)77054-0","volume":"110","author":"C Baudouin","year":"1990","unstructured":"Baudouin C, Fredj-Reygrobellet D, Gordon WC, Baudouin F, Peyman G, Lapalus P, Gastaud P, Bazan NG (1990) Immunohistologic study of epiretinal membranes in proliferative vitreoretinopathy. Am J Ophthalmol 110:593\u2013598. https:\/\/doi.org\/10.1016\/s0002-9394(14)77054-0","journal-title":"Am J Ophthalmol"},{"key":"4409_CR36","first-page":"468","volume":"90","author":"S Grisanti","year":"1993","unstructured":"Grisanti S, Wiedemann P, Heimann K (1993) Proliferative vitreoretinopathy. On the significance of protein transfer through the blood-retina barrier. Ophthalmologe 90:468\u2013471","journal-title":"Ophthalmologe"},{"key":"4409_CR37","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.semcdb.2013.01.002","volume":"24","author":"BC Jongbloets","year":"2013","unstructured":"Jongbloets BC, Ramakers GM, Pasterkamp RJ (2013) Semaphorin7A and its receptors: pleiotropic regulators of immune cell function, bone homeostasis, and neural development. Semin Cell Dev Biol 24:129\u2013138. https:\/\/doi.org\/10.1016\/j.semcdb.2013.01.002","journal-title":"Semin Cell Dev Biol"},{"key":"4409_CR38","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30340","author":"Y Song","year":"2021","unstructured":"Song Y, Wang L, Zhang L, Huang D (2021) The involvement of semaphorin 7A in tumorigenic and immunoinflammatory regulation. J Cell Physiol. https:\/\/doi.org\/10.1002\/jcp.30340","journal-title":"J Cell Physiol"},{"key":"4409_CR39","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1038\/nature05652","volume":"446","author":"K Suzuki","year":"2007","unstructured":"Suzuki K, Okuno T, Yamamoto M, Pasterkamp RJ, Takegahara N, Takamatsu H, Kitao T, Takagi J, Rennert PD, Kolodkin AL, Kumanogoh A, Kikutani H (2007) Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin. Nature 446:680\u2013684. https:\/\/doi.org\/10.1038\/nature05652","journal-title":"Nature"},{"key":"4409_CR40","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1097\/00001756-199902250-00012","volume":"10","author":"S Chen","year":"1999","unstructured":"Chen S, Jen A, Gentleman S, Jen L (1999) Effects of bFGF and TGFbeta on the expression of amyloid precursor and B-cell lymphoma protooncogene proteins in the rat retina. NeuroReport 10:509\u2013512. https:\/\/doi.org\/10.1097\/00001756-199902250-00012","journal-title":"NeuroReport"},{"key":"4409_CR41","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/nrm3068","volume":"12","author":"U Cavallaro","year":"2011","unstructured":"Cavallaro U, Dejana E (2011) Adhesion molecule signalling: not always a sticky business. Nat Rev Mol Cell Biol 12:189\u2013197. https:\/\/doi.org\/10.1038\/nrm3068","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4409_CR42","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.160258","volume":"7","author":"T Martins","year":"2017","unstructured":"Martins T, Eusebio N, Correia A, Marinho J, Casares F, Pereira PS (2017) TGF\u03b2\/Activin signalling is required for ribosome biogenesis and cell growth in <i>Drosophila<\/i> salivary glands. Open Biol 7:160258. https:\/\/doi.org\/10.1098\/rsob.160258","journal-title":"Open Biol"},{"key":"4409_CR43","first-page":"477","volume":"34","author":"GA Lutty","year":"1993","unstructured":"Lutty GA, Merges C, Threlkeld AB, Crone S, McLeod DS (1993) Heterogeneity in localization of isoforms of TGF-beta in human retina, vitreous, and choroid. Invest Ophthalmol Vis Sci 34:477\u2013487","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4409_CR44","first-page":"1258","volume":"20","author":"Y Bai","year":"2014","unstructured":"Bai Y, Liang S, Yu W, Zhao M, Huang L, Zhao M, Li X (2014) Semaphorin 3A blocks the formation of pathologic choroidal neovascularization induced by transforming growth factor beta. Mol Vis 20:1258\u20131270","journal-title":"Mol Vis"},{"key":"4409_CR45","doi-asserted-by":"publisher","first-page":"2784","DOI":"10.2337\/db08-0302","volume":"57","author":"S Kawahara","year":"2008","unstructured":"Kawahara S, Hata Y, Kita T, Arita R, Miura M, Nakao S, Mochizuki Y, Enaida H, Kagimoto T, Goto Y, Hafezi-Moghadam A, Ishibashi T (2008) Potent inhibition of cicatricial contraction in proliferative vitreoretinal diseases by statins. Diabetes 57:2784\u20132793. https:\/\/doi.org\/10.2337\/db08-0302","journal-title":"Diabetes"},{"key":"4409_CR46","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1172\/jci114065","volume":"83","author":"TB Connor Jr","year":"1989","unstructured":"Connor TB Jr, Roberts AB, Sporn MB, Danielpour D, Dart LL, Michels RG, de Bustros S, Enger C, Kato H, Lansing M et al (1989) Correlation of fibrosis and transforming growth factor-beta type 2 levels in the eye. J Clin Invest 83:1661\u20131666. https:\/\/doi.org\/10.1172\/jci114065","journal-title":"J Clin Invest"},{"key":"4409_CR47","first-page":"1210","volume":"41","author":"L Carrington","year":"2000","unstructured":"Carrington L, McLeod D, Boulton M (2000) IL-10 and antibodies to TGF-beta2 and PDGF inhibit RPE-mediated retinal contraction. Invest Ophthalmol Vis Sci 41:1210\u20131216","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4409_CR48","doi-asserted-by":"publisher","first-page":"3212","DOI":"10.1096\/fj.201800858RR","volume":"33","author":"H Yao","year":"2019","unstructured":"Yao H, Ge T, Zhang Y, Li M, Yang S, Li H, Wang F (2019) BMP7 antagonizes proliferative vitreoretinopathy through retinal pigment epithelial fibrosis in vivo and in vitro. Faseb j 33:3212\u20133224. https:\/\/doi.org\/10.1096\/fj.201800858RR","journal-title":"Faseb j"},{"key":"4409_CR49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122229","volume":"10","author":"Z Dvashi","year":"2015","unstructured":"Dvashi Z, Goldberg M, Adir O, Shapira M, Pollack A (2015) TGF-\u03b21 induced transdifferentiation of rpe cells is mediated by TAK1. PLoS ONE 10:e0122229. https:\/\/doi.org\/10.1371\/journal.pone.0122229","journal-title":"PLoS ONE"},{"key":"4409_CR50","doi-asserted-by":"publisher","first-page":"204","DOI":"10.17305\/bjbms.2010.2686","volume":"10","author":"XZ Zheng","year":"2010","unstructured":"Zheng XZ, Du LF, Wang HP (2010) An immunohistochemical analysis of a rat model of proliferative vitreoretinopathy and a comparison of the expression of TGF-\u03b2 and PDGF among the induction methods. Bosn J Basic Med Sci 10:204\u2013209. https:\/\/doi.org\/10.17305\/bjbms.2010.2686","journal-title":"Bosn J Basic Med Sci"},{"key":"4409_CR51","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.oftal.2018.08.002","volume":"94","author":"JL Palomares-Ord\u00f3\u00f1ez","year":"2019","unstructured":"Palomares-Ord\u00f3\u00f1ez JL, S\u00e1nchez-Ramos JA, Ram\u00edrez-Estudillo JA, Robles-Contreras A (2019) Correlation of transforming growth factor \u03b2-1 vitreous levels with clinical severity of proliferative vitreoretinopathy in patients with rhegmatogenous retinal detachment. Arch Soc Esp Oftalmol 94:12\u201317. https:\/\/doi.org\/10.1016\/j.oftal.2018.08.002","journal-title":"Arch Soc Esp Oftalmol"},{"key":"4409_CR52","doi-asserted-by":"publisher","first-page":"14461","DOI":"10.1016\/S0021-9258(19)85261-4","volume":"268","author":"T Shinomura","year":"1993","unstructured":"Shinomura T, Nishida Y, Ito K, Kimata K (1993) cDNA cloning of PG-M, a large chondroitin sulfate proteoglycan expressed during chondrogenesis in chick limb buds. Alternative spliced multiforms of PG-M and their relationships to versican. J Biol Chem 268:14461\u201314469","journal-title":"J Biol Chem"},{"key":"4409_CR53","doi-asserted-by":"publisher","first-page":"7528","DOI":"10.1167\/iovs.12-10797","volume":"53","author":"TD Keenan","year":"2012","unstructured":"Keenan TD, Clark SJ, Unwin RD, Ridge LA, Day AJ, Bishop PN (2012) Mapping the differential distribution of proteoglycan core proteins in the adult human retina, choroid, and sclera. Invest Ophthalmol Vis Sci 53:7528\u20137538. https:\/\/doi.org\/10.1167\/iovs.12-10797","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4409_CR54","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.brainres.2008.12.023","volume":"1256","author":"Y Inoue","year":"2009","unstructured":"Inoue Y, Yoneda M, Miyaishi O, Iwaki M, Zako M (2009) Hyaluronan dynamics during retinal development. Brain Res 1256:55\u201360. https:\/\/doi.org\/10.1016\/j.brainres.2008.12.023","journal-title":"Brain Res"},{"key":"4409_CR55","doi-asserted-by":"publisher","first-page":"2870","DOI":"10.1167\/iovs.07-1488","volume":"49","author":"A Ohno-Jinno","year":"2008","unstructured":"Ohno-Jinno A, Isogai Z, Yoneda M, Kasai K, Miyaishi O, Inoue Y, Kataoka T, Zhao JS, Li H, Takeyama M, Keene DR, Sakai LY, Kimata K, Iwaki M, Zako M (2008) Versican and fibrillin-1 form a major hyaluronan-binding complex in the ciliary body. Invest Ophthalmol Vis Sci 49:2870\u20132877. https:\/\/doi.org\/10.1167\/iovs.07-1488","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4409_CR56","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1080\/03008200802148496","volume":"49","author":"DA Theocharis","year":"2008","unstructured":"Theocharis DA, Skandalis SS, Noulas AV, Papageorgakopoulou N, Theocharis AD, Karamanos NK (2008) Hyaluronan and chondroitin sulfate proteoglycans in the supramolecular organization of the mammalian vitreous body. Connect Tissue Res 49:124\u2013128. https:\/\/doi.org\/10.1080\/03008200802148496","journal-title":"Connect Tissue Res"},{"key":"4409_CR57","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1074\/jbc.273.4.2312","volume":"273","author":"T Osterwalder","year":"1998","unstructured":"Osterwalder T, Cinelli P, Baici A, Pennella A, Krueger SR, Schrimpf SP, Meins M, Sonderegger P (1998) The axonally secreted serine proteinase inhibitor, neuroserpin, inhibits plasminogen activators and plasmin but not thrombin. J Biol Chem 273:2312\u20132321. https:\/\/doi.org\/10.1074\/jbc.273.4.2312","journal-title":"J Biol Chem"},{"key":"4409_CR58","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.mcn.2005.09.005","volume":"30","author":"N Lebeurrier","year":"2005","unstructured":"Lebeurrier N, Liot G, Lopez-Atalaya JP, Orset C, Fernandez-Monreal M, Sonderegger P, Ali C, Vivien D (2005) The brain-specific tissue-type plasminogen activator inhibitor, neuroserpin, protects neurons against excitotoxicity both in vitro and in vivo. Mol Cell Neurosci 30:552\u2013558. https:\/\/doi.org\/10.1016\/j.mcn.2005.09.005","journal-title":"Mol Cell Neurosci"},{"key":"4409_CR59","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1182\/blood.V96.2.569","volume":"96","author":"M Yepes","year":"2000","unstructured":"Yepes M, Sandkvist M, Wong MK, Coleman TA, Smith E, Cohan SL, Lawrence DA (2000) Neuroserpin reduces cerebral infarct volume and protects neurons from ischemia-induced apoptosis. Blood 96:569\u2013576","journal-title":"Blood"},{"key":"4409_CR60","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130440","volume":"10","author":"RP Gu","year":"2015","unstructured":"Gu RP, Fu LL, Jiang CH, Xu YF, Wang X, Yu J (2015) Retina is protected by neuroserpin from ischemic\/reperfusion-induced injury independent of tissue-type plasminogen activator. PLoS ONE 10:e0130440. https:\/\/doi.org\/10.1371\/journal.pone.0130440","journal-title":"PLoS ONE"},{"key":"4409_CR61","doi-asserted-by":"publisher","first-page":"8412","DOI":"10.1038\/s41598-017-08688-2","volume":"7","author":"V Gupta","year":"2017","unstructured":"Gupta V, Mirzaei M, Gupta VB, Chitranshi N, Dheer Y, Vander Wall R, Abbasi M, You Y, Chung R, Graham S (2017) Glaucoma is associated with plasmin proteolytic activation mediated through oxidative inactivation of neuroserpin. Sci Rep 7:8412\u20138412. https:\/\/doi.org\/10.1038\/s41598-017-08688-2","journal-title":"Sci Rep"},{"key":"4409_CR62","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1007\/s12031-014-0436-y","volume":"55","author":"Y Brand","year":"2015","unstructured":"Brand Y, Sung M, Pak K, Chavez E, Wei E, Radojevic V, Bodmer D, Ryan A (2015) Neural cell adhesion molecule NrCAM is expressed in the mammalian inner ear and modulates spiral ganglion neurite outgrowth in an in vitro alternate choice assay. J Mol Neurosci 55:836\u2013844. https:\/\/doi.org\/10.1007\/s12031-014-0436-y","journal-title":"J Mol Neurosci"},{"key":"4409_CR63","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.18240\/ijo.2019.11.15","volume":"12","author":"S-C Qu","year":"2019","unstructured":"Qu S-C, Xu D, Li T-T, Zhang J-F, Liu F (2019) iTRAQ-based proteomics analysis of aqueous humor in patients with dry age-related macular degeneration. Int J Ophthalmol 12:1758\u20131766. https:\/\/doi.org\/10.18240\/ijo.2019.11.15","journal-title":"Int J Ophthalmol"},{"key":"4409_CR64","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1038\/287795a0","volume":"287","author":"C N\u00fcsslein-Volhard","year":"1980","unstructured":"N\u00fcsslein-Volhard C, Wieschaus E (1980) Mutations affecting segment number and polarity in Drosophila. Nature 287:795\u2013801. https:\/\/doi.org\/10.1038\/287795a0","journal-title":"Nature"},{"key":"4409_CR65","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.conb.2004.07.004","volume":"14","author":"DE Nilsson","year":"2004","unstructured":"Nilsson DE (2004) Eye evolution: a question of genetic promiscuity. Curr Opin Neurobiol 14:407\u2013414. https:\/\/doi.org\/10.1016\/j.conb.2004.07.004","journal-title":"Curr Opin Neurobiol"},{"key":"4409_CR66","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1007\/s00439-018-1918-8","volume":"138","author":"F Cavodeassi","year":"2019","unstructured":"Cavodeassi F, Creuzet S, Etchevers HC (2019) The hedgehog pathway and ocular developmental anomalies. Hum Genet 138:917\u2013936. https:\/\/doi.org\/10.1007\/s00439-018-1918-8","journal-title":"Hum Genet"},{"key":"4409_CR67","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.preteyeres.2007.07.002","volume":"26","author":"A Cvekl","year":"2007","unstructured":"Cvekl A, Duncan MK (2007) Genetic and epigenetic mechanisms of gene regulation during lens development. Prog Retin Eye Res 26:555\u2013597. https:\/\/doi.org\/10.1016\/j.preteyeres.2007.07.002","journal-title":"Prog Retin Eye Res"},{"key":"4409_CR68","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1002\/ajmg.1320470518","volume":"47","author":"D Donnai","year":"1993","unstructured":"Donnai D, Barrow M (1993) Diaphragmatic hernia, exomphalos, absent corpus callosum, hypertelorism, myopia, and sensorineural deafness: a newly recognized autosomal recessive disorder? Am J Med Genet 47:679\u2013682. https:\/\/doi.org\/10.1002\/ajmg.1320470518","journal-title":"Am J Med Genet"},{"key":"4409_CR69","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1038\/ng2063","volume":"39","author":"S Kantarci","year":"2007","unstructured":"Kantarci S, Al-Gazali L, Hill RS, Donnai D, Black GC, Bieth E, Chassaing N, Lacombe D, Devriendt K, Teebi A, Loscertales M, Robson C, Liu T, MacLaughlin DT, Noonan KM, Russell MK, Walsh CA, Donahoe PK, Pober BR (2007) Mutations in LRP2, which encodes the multiligand receptor megalin, cause Donnai-Barrow and facio-oculo-acoustico-renal syndromes. Nat Genet 39:957\u2013959. https:\/\/doi.org\/10.1038\/ng2063","journal-title":"Nat Genet"},{"key":"4409_CR70","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1002\/bdra.20534","volume":"85","author":"BR Pober","year":"2009","unstructured":"Pober BR, Longoni M, Noonan KM (2009) A review of Donnai-Barrow and facio-oculo-acoustico-renal (DB\/FOAR) syndrome: clinical features and differential diagnosis. Birth Defects Res A Clin Mol Teratol 85:76\u201381. https:\/\/doi.org\/10.1002\/bdra.20534","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"4409_CR71","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3389\/fcell.2019.00167","volume":"7","author":"RF Collery","year":"2019","unstructured":"Collery RF, Link BA (2019) Precise short sequence insertion in zebrafish using a CRISPR\/Cas9 approach to generate a constitutively soluble Lrp2 protein. Front Cell Develop Biol 7:167\u2013167. https:\/\/doi.org\/10.3389\/fcell.2019.00167","journal-title":"Front Cell Develop Biol"},{"key":"4409_CR72","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0129518","volume":"10","author":"O Cases","year":"2015","unstructured":"Cases O, Joseph A, Obry A, Santin MD, Ben-Yacoub S, P\u00e2ques M, Amsellem-Levera S, Bribian A, Simonutti M, Augustin S, Debeir T, Sahel JA, Christ A, de Castro F, Leh\u00e9ricy S, Cosette P, Kozyraki R (2015) Foxg1-Cre mediated Lrp2 inactivation in the developing mouse neural retina, ciliary and retinal pigment epithelia models congenital high myopia. PLoS ONE 10:e0129518. https:\/\/doi.org\/10.1371\/journal.pone.0129518","journal-title":"PLoS ONE"},{"key":"4409_CR73","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001310","volume":"7","author":"KN Veth","year":"2011","unstructured":"Veth KN, Willer JR, Collery RF, Gray MP, Willer GB, Wagner DS, Mullins MC, Udvadia AJ, Smith RS, John SW, Gregg RG, Link BA (2011) Mutations in zebrafish lrp2 result in adult-onset ocular pathogenesis that models myopia and other risk factors for glaucoma. PLoS Genet 7:e1001310. https:\/\/doi.org\/10.1371\/journal.pgen.1001310","journal-title":"PLoS Genet"},{"key":"4409_CR74","doi-asserted-by":"crossref","unstructured":"Collery R, Link B (2018) Proteolytic processing of LRP2 on RPE cells regulates BMP activity to control eye size and refractive error","DOI":"10.1101\/365817"},{"key":"4409_CR75","doi-asserted-by":"publisher","first-page":"3183","DOI":"10.1093\/hmg\/ddaa200","volume":"29","author":"A Christ","year":"2020","unstructured":"Christ A, Marczenke M, Willnow TE (2020) LRP2 controls sonic hedgehog-dependent differentiation of cardiac progenitor cells during outflow tract formation. Hum Mol Genet 29:3183\u20133196. https:\/\/doi.org\/10.1093\/hmg\/ddaa200","journal-title":"Hum Mol Genet"},{"key":"4409_CR76","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.devcel.2011.11.023","volume":"22","author":"A Christ","year":"2012","unstructured":"Christ A, Christa A, Kur E, Lioubinski O, Bachmann S, Willnow TE, Hammes A (2012) LRP2 is an auxiliary SHH receptor required to condition the forebrain ventral midline for inductive signals. Dev Cell 22:268\u2013278. https:\/\/doi.org\/10.1016\/j.devcel.2011.11.023","journal-title":"Dev Cell"},{"key":"4409_CR77","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.devcel.2015.09.001","volume":"35","author":"A Christ","year":"2015","unstructured":"Christ A, Christa A, Klippert J, Eule JC, Bachmann S, Wallace VA, Hammes A, Willnow TE (2015) LRP2 Acts as SHH clearance receptor to protect the retinal margin from mitogenic stimuli. Dev Cell 35:36\u201348. https:\/\/doi.org\/10.1016\/j.devcel.2015.09.001","journal-title":"Dev Cell"},{"key":"4409_CR78","doi-asserted-by":"publisher","first-page":"16655","DOI":"10.1074\/jbc.M113.451070","volume":"288","author":"O Cases","year":"2013","unstructured":"Cases O, Perea-Gomez A, Aguiar DP, Nykjaer A, Amsellem S, Chandellier J, Umbhauer M, Cereghini S, Madsen M, Collignon J, Verroust P, Riou JF, Creuzet SE, Kozyraki R (2013) Cubilin, a high affinity receptor for fibroblast growth factor 8, is required for cell survival in the developing vertebrate head. J Biol Chem 288:16655\u201316670. https:\/\/doi.org\/10.1074\/jbc.M113.451070","journal-title":"J Biol Chem"},{"key":"4409_CR79","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1242\/dev.01580","volume":"132","author":"R Spoelgen","year":"2005","unstructured":"Spoelgen R, Hammes A, Anzenberger U, Zechner D, Andersen OM, Jerchow B, Willnow TE (2005) LRP2\/megalin is required for patterning of the ventral telencephalon. Development 132:405\u2013414. https:\/\/doi.org\/10.1242\/dev.01580","journal-title":"Development"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-022-04409-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-022-04409-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-022-04409-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T09:15:55Z","timestamp":1651655755000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-022-04409-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,25]]},"references-count":79,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["4409"],"URL":"https:\/\/doi.org\/10.1007\/s11010-022-04409-0","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,25]]},"assertion":[{"value":"4 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study adhered to the guidelines of the Declaration of Helsinki and the ethics committee of Nanjing Medical University affiliated Wuxi No. 2 Hospital approved the study (Wuxi, China. Identification code: 2019Y-30).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All the participating patients in this study provided signed, informed consent prior to the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}