{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T04:19:42Z","timestamp":1788754782124,"version":"build-2803163510"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T00:00:00Z","timestamp":1649289600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T00:00:00Z","timestamp":1649289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Preeclampsia (PE) is a major complication of pregnancy with partially elucidated pathophysiology. Placental mitochondrial dysfunction has been increasingly studied as major pathomechanism in both early- and late-onset PE. Impairment of mitochondrial respiration in platelets has recently emerged as a peripheral biomarker that may mirror organ mitochondrial dysfunction in several acute and chronic pathologies. The present study was purported to assess mitochondrial respiratory dys\/function in both platelets and placental mitochondria in PE pregnancies. To this aim, a high-resolution respirometry SUIT (Substrate-Uncoupler-Inhibitor-Titration) protocol was adapted to assess complex I (glutamate\u2009+\u2009malate)- and complex II (succinate)-supported respiration. A decrease in all respiratory parameters (basal, coupled, and maximal uncoupled respiration) in peripheral platelets was found in preeclamptic as compared to healthy pregnancies. At variance, placental mitochondria showed a dichotomous behavior in preeclampsia in relation to the fetal birth weight. PE pregnancies with fetal growth restriction were associated with decreased in coupled respiration (oxidative phosphorylation\/OXPHOS capacity) and maximal uncoupled respiration (electron transfer\/ET capacity). At variance, these respiratory parameters were increased for both complex I- and II-supported respiration in PE pregnancies with normal weight fetuses. Large randomized controlled clinical studies are needed in order to advance our understanding of mitochondrial adaptive vs. pathological changes in preeclampsia.<\/jats:p>","DOI":"10.1007\/s11010-022-04415-2","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T06:03:03Z","timestamp":1649311383000},"page":"1987-2000","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Impairment of mitochondrial respiration in platelets and placentas: a pilot study in preeclamptic pregnancies"],"prefix":"10.1007","volume":"477","author":[{"given":"Anca M.","family":"B\u00een\u0103","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oana M.","family":"Aburel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vlad F.","family":"Avram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theia","family":"Lelcu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adina V.","family":"Lin\u021ba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela V.","family":"Chiriac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelina G.","family":"Mocanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Bernad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Borza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius L.","family":"Craina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoran L.","family":"Popa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6186-5321","authenticated-orcid":false,"given":"Danina M.","family":"Muntean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavian M.","family":"Cre\u021bu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,7]]},"reference":[{"key":"4415_CR1","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1152\/physrev.00029.2015","volume":"96","author":"GJ Burton","year":"2016","unstructured":"Burton GJ, Fowden AL, Thornburg KL (2016) Placental origins of chronic disease. Physiol Rev 96:1509\u20131565. https:\/\/doi.org\/10.1152\/physrev.00029.2015","journal-title":"Physiol Rev"},{"issue":"Suppl 1","key":"4415_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/ijgo.12802","volume":"145","author":"LC Poon","year":"2019","unstructured":"Poon LC, Shennan A, Hyett JA, Kapur A, Hadar E, Divakar H, McAuliffe F, da Silva Costa F, von Dadelszen P, McIntyre HD et al (2019) The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre-eclampsia: a pragmatic guide for first-trimester screening and prevention. Int J Gynaecol Obstet 145(Suppl 1):1\u201333. https:\/\/doi.org\/10.1002\/ijgo.12802","journal-title":"Int J Gynaecol Obstet"},{"key":"4415_CR3","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.ccl.2019.04.008","volume":"37","author":"S Shah","year":"2019","unstructured":"Shah S, Gupta A (2019) Hypertensive disorders of pregnancy. Cardiol Clin 37:345\u2013354. https:\/\/doi.org\/10.1016\/j.ccl.2019.04.008","journal-title":"Cardiol Clin"},{"key":"4415_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165961","volume":"1866","author":"R Mar\u00edn","year":"2020","unstructured":"Mar\u00edn R, Chiarello DI, Abad C, Rojas D, Toledo F, Sobrevia L (2020) Oxidative stress and mitochondrial dysfunction in early-onset and late-onset preeclampsia. Biochim Biophys Acta Mol Basis Dis 1866:165961. https:\/\/doi.org\/10.1016\/j.bbadis.2020.165961","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"4415_CR5","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1161\/hypertensionaha.117.10803","volume":"72","author":"MA Brown","year":"2018","unstructured":"Brown MA, Magee LA, Kenny LC, Karumanchi SA, McCarthy FP, Saito S, Hall DR, Warren CE, Adoyi G, Ishaku S (2018) Hypertensive disorders of pregnancy: ISSHP classification, diagnosis, and management recommendations for international practice. Hypertension 72:24\u201343. https:\/\/doi.org\/10.1161\/hypertensionaha.117.10803","journal-title":"Hypertension"},{"key":"4415_CR6","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1097\/OGX.0b013e3182331028","volume":"66","author":"D Raymond","year":"2011","unstructured":"Raymond D, Peterson E (2011) A critical review of early-onset and late-onset preeclampsia. Obstet Gynecol Surv 66:497\u2013506. https:\/\/doi.org\/10.1097\/OGX.0b013e3182331028","journal-title":"Obstet Gynecol Surv"},{"key":"4415_CR7","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.2215\/cjn.12081115","volume":"11","author":"E Phipps","year":"2016","unstructured":"Phipps E, Prasanna D, Brima W, Jim B (2016) Preeclampsia: updates in pathogenesis, definitions, and guidelines. Clin J Am Soc Nephrol 11:1102\u20131113. https:\/\/doi.org\/10.2215\/cjn.12081115","journal-title":"Clin J Am Soc Nephrol"},{"key":"4415_CR8","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1093\/humupd\/dmaa053","volume":"27","author":"A Colson","year":"2021","unstructured":"Colson A, Sonveaux P, Debi\u00e8ve F, Sferruzzi-Perri AN (2021) Adaptations of the human placenta to hypoxia: opportunities for interventions in fetal growth restriction. Hum Reprod Update 27:531\u2013569. https:\/\/doi.org\/10.1093\/humupd\/dmaa053","journal-title":"Hum Reprod Update"},{"key":"4415_CR9","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1161\/HYPERTENSIONAHA.115.06357","volume":"67","author":"AC Staff","year":"2016","unstructured":"Staff AC, Redman CW, Williams D, Leeson P, Moe K, Thilaganathan B, Magnus P, Steegers EA, Tsigas EZ, Ness RB et al (2016) Pregnancy and long-term maternal cardiovascular health: progress through harmonization of research cohorts and biobanks. Hypertension 67:251\u2013260. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.115.06357","journal-title":"Hypertension"},{"key":"4415_CR10","doi-asserted-by":"publisher","first-page":"2704","DOI":"10.1016\/j.ajpath.2018.07.027","volume":"188","author":"AM Nuzzo","year":"2018","unstructured":"Nuzzo AM, Camm EJ, Sferruzzi-Perri AN, Ashmore TJ, Yung HW, Cindrova-Davies T, Spiroski AM, Sutherland MR, Logan A, Austin-Williams S et al (2018) Placental adaptation to early-onset hypoxic pregnancy and mitochondria-targeted antioxidant therapy in a rodent model. Am J Pathol 188:2704\u20132716. https:\/\/doi.org\/10.1016\/j.ajpath.2018.07.027","journal-title":"Am J Pathol"},{"key":"4415_CR11","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1161\/hypertensionaha.118.11290","volume":"72","author":"VR Vaka","year":"2018","unstructured":"Vaka VR, McMaster KM, Cunningham MW Jr, Ibrahim T, Hazlewood R, Usry N, Cornelius DC, Amaral LM, LaMarca B (2018) Role of mitochondrial dysfunction and reactive oxygen species in mediating hypertension in the reduced uterine perfusion pressure rat model of preeclampsia. Hypertension 72:703\u2013711. https:\/\/doi.org\/10.1161\/hypertensionaha.118.11290","journal-title":"Hypertension"},{"key":"4415_CR12","doi-asserted-by":"publisher","first-page":"E404","DOI":"10.1152\/ajpendo.00426.2013","volume":"306","author":"C Mand\u00f2","year":"2014","unstructured":"Mand\u00f2 C, De Palma C, Stampalija T, Anelli GM, Figus M, Novielli C, Parisi F, Clementi E, Ferrazzi E, Cetin I (2014) Placental mitochondrial content and function in intrauterine growth restriction and preeclampsia. Am J Physiol Endocrinol Metabol 306:E404-413. https:\/\/doi.org\/10.1152\/ajpendo.00426.2013","journal-title":"Am J Physiol Endocrinol Metabol"},{"key":"4415_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10215063","author":"R Vaka","year":"2021","unstructured":"Vaka R, Deer E, Cunningham M, McMaster KM, Wallace K, Cornelius DC, Amaral LM, LaMarca B (2021) Characterization of mitochondrial bioenergetics in preeclampsia. J Clin Med. https:\/\/doi.org\/10.3390\/jcm10215063","journal-title":"J Clin Med"},{"key":"4415_CR14","doi-asserted-by":"publisher","first-page":"2186","DOI":"10.1007\/s43032-021-00464-y","volume":"28","author":"P Vangrieken","year":"2021","unstructured":"Vangrieken P, Al-Nasiry S, Bast A, Leermakers PA, Tulen CBM, Schiffers PMH, van Schooten FJ, Remels AHV (2021) Placental mitochondrial abnormalities in preeclampsia. Reprod Sci 28:2186\u20132199. https:\/\/doi.org\/10.1007\/s43032-021-00464-y","journal-title":"Reprod Sci"},{"key":"4415_CR15","doi-asserted-by":"publisher","first-page":"372","DOI":"10.3389\/fphys.2014.00372","volume":"5","author":"LC S\u00e1nchez-Aranguren","year":"2014","unstructured":"S\u00e1nchez-Aranguren LC, Prada CE, Ria\u00f1o-Medina CE, Lopez M (2014) Endothelial dysfunction and preeclampsia: role of oxidative stress. Front Physiol 5:372\u2013372. https:\/\/doi.org\/10.3389\/fphys.2014.00372","journal-title":"Front Physiol"},{"key":"4415_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/ijms221910732","author":"D Forstner","year":"2021","unstructured":"Forstner D, Guettler J, Gauster M (2021) Changes in maternal platelet physiology during gestation and their interaction with trophoblasts. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms221910732","journal-title":"Int J Mol Sci"},{"key":"4415_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2019.100835","volume":"71","author":"A Braganza","year":"2020","unstructured":"Braganza A, Annarapu GK, Shiva S (2020) Blood-based bioenergetics: an emerging translational and clinical tool. Mol Aspects Med 71:100835. https:\/\/doi.org\/10.1016\/j.mam.2019.100835","journal-title":"Mol Aspects Med"},{"key":"4415_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/life11090949","author":"R Acin-Perez","year":"2021","unstructured":"Acin-Perez R, Beninc\u00e1 C, Shabane B, Shirihai OS, Stiles L (2021) Utilization of human samples for assessment of mitochondrial bioenergetics: gold standards, limitations, and future perspectives. Life. https:\/\/doi.org\/10.3390\/life11090949","journal-title":"Life"},{"key":"4415_CR19","doi-asserted-by":"publisher","first-page":"347","DOI":"10.33549\/physiolres.934032","volume":"68","author":"AT Petrus","year":"2019","unstructured":"Petrus AT, Lighezan DL, Danila MD, Duicu OM, Sturza A, Muntean DM, Ionita I (2019) Assessment of platelet respiration as emerging biomarker of disease. Physiol Res 68:347\u2013363. https:\/\/doi.org\/10.33549\/physiolres.934032","journal-title":"Physiol Res"},{"key":"4415_CR20","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.mito.2012.11.001","volume":"13","author":"F Sj\u00f6vall","year":"2013","unstructured":"Sj\u00f6vall F, Ehinger JK, Marelsson SE, Morota S, Frostner EA, Uchino H, Lundgren J, Arnbj\u00f6rnsson E, Hansson MJ, Fellman V et al (2013) Mitochondrial respiration in human viable platelets\u2013methodology and influence of gender, age and storage. Mitochondrion 13:7\u201314. https:\/\/doi.org\/10.1016\/j.mito.2012.11.001","journal-title":"Mitochondrion"},{"key":"4415_CR21","doi-asserted-by":"crossref","unstructured":"Gnaiger E, Kuznetsov A, Schneeberger S, Seiler R, Brandacher G, Steurer W, Margreiter R (2000) Mitochondria in the cold. 431\u2013442","DOI":"10.1007\/978-3-662-04162-8_45"},{"key":"4415_CR22","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1002\/uog.22134","volume":"56","author":"CC Lees","year":"2020","unstructured":"Lees CC, Stampalija T, Baschat A, da Silva Costa F, Ferrazzi E, Figueras F, Hecher K, Kingdom J, Poon LC, Salomon LJ et al (2020) ISUOG practice guidelines: diagnosis and management of small-for-gestational-age fetus and fetal growth restriction. Ultrasound Obstetr Gynecol 56:298\u2013312. https:\/\/doi.org\/10.1002\/uog.22134","journal-title":"Ultrasound Obstetr Gynecol"},{"key":"4415_CR23","doi-asserted-by":"publisher","first-page":"32410","DOI":"10.1038\/srep32410","volume":"6","author":"PA Vishnyakova","year":"2016","unstructured":"Vishnyakova PA, Volodina MA, Tarasova NV, Marey MV, Tsvirkun DV, Vavina OV, Khodzhaeva ZS, Kan NE, Menon R, Vysokikh MY et al (2016) Mitochondrial role in adaptive response to stress conditions in preeclampsia. Sci Rep 6:32410. https:\/\/doi.org\/10.1038\/srep32410","journal-title":"Sci Rep"},{"key":"4415_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.placenta.2007.05.010","volume":"29","author":"TM Mayhew","year":"2008","unstructured":"Mayhew TM (2008) Taking tissue samples from the placenta: an illustration of principles and strategies. Placenta 29:1\u201314. https:\/\/doi.org\/10.1016\/j.placenta.2007.05.010","journal-title":"Placenta"},{"key":"4415_CR25","doi-asserted-by":"publisher","first-page":"5478","DOI":"10.1073\/pnas.0508035103","volume":"103","author":"R Sood","year":"2006","unstructured":"Sood R, Zehnder JL, Druzin ML, Brown PO (2006) Gene expression patterns in human placenta. Proc Natl Acad Sci USA 103:5478\u20135483. https:\/\/doi.org\/10.1073\/pnas.0508035103","journal-title":"Proc Natl Acad Sci USA"},{"key":"4415_CR26","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/S0021-9258(18)57021-6","volume":"177","author":"AG Gornall","year":"1949","unstructured":"Gornall AG, Bardawill CJ, David MM (1949) Determination of serum proteins by means of the biuret reaction. J Biol Chem 177:751\u2013766","journal-title":"J Biol Chem"},{"key":"4415_CR27","doi-asserted-by":"publisher","first-page":"H1633","DOI":"10.1152\/ajpheart.00701.2003","volume":"286","author":"AV Kuznetsov","year":"2004","unstructured":"Kuznetsov AV, Schneeberger S, Seiler R, Brandacher G, Mark W, Steurer W, Saks V, Usson Y, Margreiter R, Gnaiger E (2004) Mitochondrial defects and heterogeneous cytochrome c release after cardiac cold ischemia and reperfusion. Am J Physiol Heart Circul Physiol 286:H1633-1641. https:\/\/doi.org\/10.1152\/ajpheart.00701.2003","journal-title":"Am J Physiol Heart Circul Physiol"},{"key":"4415_CR28","doi-asserted-by":"publisher","first-page":"792","DOI":"10.5603\/GP.a2021.0056","volume":"92","author":"M Temur","year":"2021","unstructured":"Temur M, Ta\u015fg\u00f6z FN, \u00c7ift T, Serpim G, \u00dcst\u00fcnyurt E (2021) Role of platelet indices in prediction of preeclampsia. Ginekol Pol 92:792\u2013796. https:\/\/doi.org\/10.5603\/GP.a2021.0056","journal-title":"Ginekol Pol"},{"key":"4415_CR29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0225536","volume":"14","author":"F Tesfay","year":"2019","unstructured":"Tesfay F, Negash M, Alemu J, Yahya M, Teklu G, Yibrah M, Asfaw T, Tsegaye A (2019) Role of platelet parameters in early detection and prediction of severity of preeclampsia: a comparative cross-sectional study at Ayder comprehensive specialized and Mekelle general hospitals, Mekelle, Tigray, Ethiopia. PLoS ONE 14:e0225536. https:\/\/doi.org\/10.1371\/journal.pone.0225536","journal-title":"PLoS ONE"},{"key":"4415_CR30","unstructured":"Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis, 5th ed."},{"key":"4415_CR31","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.2353\/ajpath.2007.070528","volume":"171","author":"T Cindrova-Davies","year":"2007","unstructured":"Cindrova-Davies T, Yung HW, Johns J, Spasic-Boskovic O, Korolchuk S, Jauniaux E, Burton GJ, Charnock-Jones DS (2007) Oxidative stress, gene expression, and protein changes induced in the human placenta during labor. Am J Pathol 171:1168\u20131179. https:\/\/doi.org\/10.2353\/ajpath.2007.070528","journal-title":"Am J Pathol"},{"key":"4415_CR32","doi-asserted-by":"publisher","first-page":"434","DOI":"10.3109\/10641955.2015.1060244","volume":"34","author":"K Dogan","year":"2015","unstructured":"Dogan K, Guraslan H, Senturk MB, Helvacioglu C, Idil S, Ekin M (2015) Can platelet count and platelet indices predict the risk and the prognosis of preeclampsia? Hypertens Pregnancy 34:434\u2013442. https:\/\/doi.org\/10.3109\/10641955.2015.1060244","journal-title":"Hypertens Pregnancy"},{"key":"4415_CR33","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.htct.2018.08.008","volume":"41","author":"N Thalor","year":"2019","unstructured":"Thalor N, Singh K, Pujani M, Chauhan V, Agarwal C, Ahuja R (2019) A correlation between platelet indices and preeclampsia. Hematol Transfus Cell Ther 41:129\u2013133. https:\/\/doi.org\/10.1016\/j.htct.2018.08.008","journal-title":"Hematol Transfus Cell Ther"},{"key":"4415_CR34","doi-asserted-by":"publisher","first-page":"696","DOI":"10.2478\/s11536-011-0076-3","volume":"6","author":"G Babi\u0107","year":"2011","unstructured":"Babi\u0107 G, Novokmet S, Jankovic S (2011) Changes of platelets\u2019 function in preeclampsia. Open Med 6:696\u2013700. https:\/\/doi.org\/10.2478\/s11536-011-0076-3","journal-title":"Open Med"},{"key":"4415_CR35","doi-asserted-by":"publisher","unstructured":"Malinow AM, Schuh RA, Alyamani O, Kim J, Bharadwaj S, Crimmins SD, Galey JL, Fiskum G, Polster BM (2018) Platelets in preeclamptic pregnancies fail to exhibit the decrease in mitochondrial oxygen consumption rate seen in normal pregnancies. Biosci Rep. https:\/\/doi.org\/10.1042\/bsr20180286","DOI":"10.1042\/bsr20180286"},{"key":"4415_CR36","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6797460","author":"I Pilchova","year":"2017","unstructured":"Pilchova I, Klacanova K, Tatarkova Z, Kaplan P, Racay P (2017) The involvement of Mg(2+) in regulation of cellular and mitochondrial functions. Oxid Med Cell Longev. https:\/\/doi.org\/10.1155\/2017\/6797460","journal-title":"Oxid Med Cell Longev"},{"key":"4415_CR37","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1055\/s-0031-1285833","volume":"120","author":"C Avila","year":"2012","unstructured":"Avila C, Huang RJ, Stevens MV, Aponte AM, Tripodi D, Kim KY, Sack MN (2012) Platelet mitochondrial dysfunction is evident in type 2 diabetes in association with modifications of mitochondrial anti-oxidant stress proteins. Exp Clin Endocrinol Diabetes 120:248\u2013251. https:\/\/doi.org\/10.1055\/s-0031-1285833","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"4415_CR38","doi-asserted-by":"publisher","DOI":"10.3390\/life11040288","author":"VF Avram","year":"2021","unstructured":"Avram VF, B\u00eena AM, Sima A, Aburel OM, Sturza A, Burlacu O, Timar RZ, Muntean DM, Elm\u00e9r E, Cre\u021bu OM (2021) Improvement of platelet respiration by cell-permeable succinate in diabetic patients treated with statins. Life. https:\/\/doi.org\/10.3390\/life11040288","journal-title":"Life"},{"key":"4415_CR39","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1089\/ars.2018.7627","volume":"31","author":"D Winnica","year":"2019","unstructured":"Winnica D, Corey C, Mullett S, Reynolds M, Hill G, Wendell S, Que L, Holguin F, Shiva S (2019) Bioenergetic differences in the airway epithelium of lean versus obese asthmatics are driven by nitric oxide and reflected in circulating platelets. Antioxid Redox Signal 31:673\u2013686. https:\/\/doi.org\/10.1089\/ars.2018.7627","journal-title":"Antioxid Redox Signal"},{"key":"4415_CR40","doi-asserted-by":"publisher","first-page":"E503","DOI":"10.1152\/ajpendo.00084.2019","volume":"317","author":"S Rose","year":"2019","unstructured":"Rose S, Carvalho E, Diaz EC, Cotter M, Bennuri SC, Azhar G, Frye RE, Adams SH, B\u00f8rsheim E (2019) A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women. Am J Physiol Endocrinol Metab 317:E503-e512. https:\/\/doi.org\/10.1152\/ajpendo.00084.2019","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"4415_CR41","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1038\/s41419-018-1190-9","volume":"9","author":"OJ Holland","year":"2018","unstructured":"Holland OJ, Cuffe JSM, Dekker Nitert M, Callaway L, Kwan Cheung KA, Radenkovic F, Perkins AV (2018) Placental mitochondrial adaptations in preeclampsia associated with progression to term delivery. Cell Death Dis 9:1150. https:\/\/doi.org\/10.1038\/s41419-018-1190-9","journal-title":"Cell Death Dis"},{"key":"4415_CR42","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.697022","volume":"12","author":"H Liu","year":"2021","unstructured":"Liu H, Tenzing N, van Patot MT, Qile M, Ge RL, Wuren T (2021) Enhanced placental mitochondrial respiration in tibetan women at high altitude. Front Physiol 12:697022. https:\/\/doi.org\/10.3389\/fphys.2021.697022","journal-title":"Front Physiol"},{"key":"4415_CR43","doi-asserted-by":"publisher","first-page":"3962","DOI":"10.1111\/jcmm.14282","volume":"23","author":"M Guitart-Mampel","year":"2019","unstructured":"Guitart-Mampel M, Juarez-Flores DL, Youssef L, Moren C, Garcia-Otero L, Roca-Agujetas V, Catalan-Garcia M, Gonzalez-Casacuberta I, Tobias E, Milisenda JC et al (2019) Mitochondrial implications in human pregnancies with intrauterine growth restriction and associated cardiac remodelling. J Cell Mol Med 23:3962\u20133973. https:\/\/doi.org\/10.1111\/jcmm.14282","journal-title":"J Cell Mol Med"},{"key":"4415_CR44","doi-asserted-by":"publisher","first-page":"2911","DOI":"10.1080\/14767058.2016.1268594","volume":"30","author":"M Beyramzadeh","year":"2017","unstructured":"Beyramzadeh M, Dikmen ZG, Erturk NK, Tuncer ZS, Akbiyik F (2017) Placental respiratory chain complex activities in high risk pregnancies. J Maternal-Fetal Neonatal Med 30:2911\u20132917. https:\/\/doi.org\/10.1080\/14767058.2016.1268594","journal-title":"J Maternal-Fetal Neonatal Med"},{"key":"4415_CR45","doi-asserted-by":"publisher","first-page":"e55194","DOI":"10.1371\/journal.pone.0055194","volume":"8","author":"F Colleoni","year":"2013","unstructured":"Colleoni F, Padmanabhan N, Yung HW, Watson ED, Cetin I, Tissot van Patot MC, Burton GJ, Murray AJ (2013) Suppression of mitochondrial electron transport chain function in the hypoxic human placenta: a role for miRNA-210 and protein synthesis inhibition. PLoS ONE 8:e55194. https:\/\/doi.org\/10.1371\/journal.pone.0055194","journal-title":"PLoS ONE"},{"key":"4415_CR46","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/978-1-4939-1031-1_12","volume":"814","author":"L Myatt","year":"2014","unstructured":"Myatt L, Muralimanoharan S, Maloyan A (2014) Effect of preeclampsia on placental function: influence of sexual dimorphism, microRNA\u2019s and mitochondria. Adv Exp Med Biol 814:133\u2013146. https:\/\/doi.org\/10.1007\/978-1-4939-1031-1_12","journal-title":"Adv Exp Med Biol"},{"key":"4415_CR47","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3109\/00016348909009902","volume":"68","author":"T Torbergsen","year":"1989","unstructured":"Torbergsen T, Oian P, Mathiesen E, Borud O (1989) Pre-eclampsia\u2013a mitochondrial disease? Acta Obstet Gynecol Scand 68:145\u2013148. https:\/\/doi.org\/10.3109\/00016348909009902","journal-title":"Acta Obstet Gynecol Scand"},{"key":"4415_CR48","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1017\/s204017441900014x","volume":"10","author":"W Tong","year":"2019","unstructured":"Tong W, Giussani DA (2019) Preeclampsia link to gestational hypoxia. J Dev Orig Health Dis 10:322\u2013333. https:\/\/doi.org\/10.1017\/s204017441900014x","journal-title":"J Dev Orig Health Dis"},{"key":"4415_CR49","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10030405","author":"XQ Hu","year":"2021","unstructured":"Hu XQ, Zhang L (2021) Hypoxia and mitochondrial dysfunction in pregnancy complications. Antioxidants. https:\/\/doi.org\/10.3390\/antiox10030405","journal-title":"Antioxidants"},{"key":"4415_CR50","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1161\/hypertensionaha.108.117358","volume":"52","author":"H Valensise","year":"2008","unstructured":"Valensise H, Vasapollo B, Gagliardi G, Novelli GP (2008) Early and late preeclampsia: two different maternal hemodynamic states in the latent phase of the disease. Hypertension 52:873\u2013880. https:\/\/doi.org\/10.1161\/hypertensionaha.108.117358","journal-title":"Hypertension"},{"key":"4415_CR51","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1161\/hypertensionaha.120.14781","volume":"77","author":"JM Roberts","year":"2021","unstructured":"Roberts JM, Rich-Edwards JW, McElrath TF, Garmire L, Myatt L (2021) Subtypes of preeclampsia: recognition and determining clinical usefulness. Hypertension 77:1430\u20131441. https:\/\/doi.org\/10.1161\/hypertensionaha.120.14781","journal-title":"Hypertension"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-022-04415-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-022-04415-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-022-04415-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T17:12:27Z","timestamp":1655572347000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-022-04415-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,7]]},"references-count":51,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["4415"],"URL":"https:\/\/doi.org\/10.1007\/s11010-022-04415-2","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,7]]},"assertion":[{"value":"6 January 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study protocol and informed consent were approved by\u00a0the Committee of Research Ethics of \u201c<i>Victor Babe\u015f<\/i>\u201d University of Medicine and Pharmacy, Timi\u015foara, Romania (no. 7\/30.01.2019 and 28\/25.06.2020).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all subjects involved in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}