{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:44:59Z","timestamp":1786981499229,"version":"build-2736575974"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,8,7]],"date-time":"2022-08-07T00:00:00Z","timestamp":1659830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,8,7]],"date-time":"2022-08-07T00:00:00Z","timestamp":1659830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Project of Henan Medical Science and Technology in 2018","award":["No. 2018020023"],"award-info":[{"award-number":["No. 2018020023"]}]},{"name":"the Project of Henan Medical Science and Technology in 2018","award":["No. 2018020141"],"award-info":[{"award-number":["No. 2018020141"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 81901974"],"award-info":[{"award-number":["No. 81901974"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1007\/s11010-022-04484-3","type":"journal-article","created":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T23:14:21Z","timestamp":1659827661000},"page":"249-260","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Exosomes from human urine-derived stem cells carry NRF1 to alleviate bladder fibrosis via regulating miR-301b-3p\/TGF\u03b2R1 pathway"],"prefix":"10.1007","volume":"478","author":[{"given":"Junwei","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyuan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yudong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5574-2138","authenticated-orcid":false,"given":"Qingwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,7]]},"reference":[{"issue":"7","key":"4484_CR1","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1111\/j.1464-410X.2010.09993.x","volume":"108","author":"DE Irwin","year":"2011","unstructured":"Irwin DE, Kopp ZS, Agatep B, Milsom I, Abrams P (2011) Worldwide prevalence estimates of lower urinary tract symptoms, overactive bladder, urinary incontinence and bladder outlet obstruction. BJU Int 108(7):1132\u20131138","journal-title":"BJU Int"},{"issue":"6","key":"4484_CR2","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1016\/j.eururo.2014.12.038","volume":"67","author":"C Gratzke","year":"2015","unstructured":"Gratzke C, Bachmann A, Descazeaud A, Drake MJ, Madersbacher S, Mamoulakis C, Oelke M, Tikkinen KAO, Gravas S (2015) EAU guidelines on the assessment of non-neurogenic male lower urinary tract symptoms including benign prostatic obstruction. Eur Urol 67(6):1099\u20131109","journal-title":"Eur Urol"},{"issue":"1","key":"4484_CR3","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s12894-018-0329-4","volume":"18","author":"F Fusco","year":"2018","unstructured":"Fusco F, Creta M, De Nunzio C, Iacovelli V, Mangiapia F, Li Marzi V, Finazzi Agro E (2018) Progressive bladder remodeling due to bladder outlet obstruction: a systematic review of morphological and molecular evidences in humans. BMC Urol 18(1):15","journal-title":"BMC Urol"},{"issue":"6","key":"4484_CR4","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1111\/bju.12687","volume":"114","author":"M Jock","year":"2014","unstructured":"Jock M, Leggett RE, Schuler C, Callaghan C, Levin RM (2014) Effect of partial bladder outlet obstruction and reversal on rabbit bladder physiology and biochemistry: duration of recovery period and severity of function. BJU Int 114(6):946\u2013954","journal-title":"BJU Int"},{"key":"4484_CR5","doi-asserted-by":"publisher","first-page":"4686259","DOI":"10.1155\/2018\/4686259","volume":"2018","author":"L Chen","year":"2018","unstructured":"Chen L, Li L, Xing F, Peng J, Peng K, Wang Y, Xiang Z (2018) Human urine-derived stem cells: potential for cell-based therapy of cartilage defects. Stem Cells Int 2018:4686259","journal-title":"Stem Cells Int"},{"issue":"4","key":"4484_CR6","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/s10735-018-9772-5","volume":"49","author":"T Zhao","year":"2018","unstructured":"Zhao T, Luo D, Sun Y, Niu X, Wang Y, Wang C, Jia W (2018) Human urine-derived stem cells play a novel role in the treatment of STZ-induced diabetic mice. J Mol Histol 49(4):419\u2013428","journal-title":"J Mol Histol"},{"issue":"15\u201316","key":"4484_CR7","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1089\/ten.tea.2010.0637","volume":"17","author":"S Bharadwaj","year":"2011","unstructured":"Bharadwaj S, Liu G, Shi Y, Markert C, Andersson KE, Atala A, Zhang Y (2011) Characterization of urine-derived stem cells obtained from upper urinary tract for use in cell-based urological tissue engineering. Tissue Eng Part A 17(15\u201316):2123\u20132132","journal-title":"Tissue Eng Part A"},{"issue":"1","key":"4484_CR8","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.gendis.2014.07.001","volume":"1","author":"D Zhang","year":"2014","unstructured":"Zhang D, Wei G, Li P, Zhou X, Zhang Y (2014) Urine-derived stem cells: a novel and versatile progenitor source for cell-based therapy and regenerative medicine. Genes Dis 1(1):8\u201317","journal-title":"Genes Dis"},{"key":"4484_CR9","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.mce.2016.03.001","volume":"427","author":"X Dong","year":"2016","unstructured":"Dong X, Zhang T, Liu Q, Zhu J, Zhao J, Li J, Sun B, Ding G, Hu X, Yang Z et al (2016) Beneficial effects of urine-derived stem cells on fibrosis and apoptosis of myocardial, glomerular and bladder cells. Mol Cell Endocrinol 427:21\u201332","journal-title":"Mol Cell Endocrinol"},{"key":"4484_CR10","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.semcdb.2015.03.001","volume":"40","author":"RC Lai","year":"2015","unstructured":"Lai RC, Yeo RW, Lim SK (2015) Mesenchymal stem cell exosomes. Semin Cell Dev Biol 40:82\u201388","journal-title":"Semin Cell Dev Biol"},{"issue":"10","key":"4484_CR11","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1016\/j.jprot.2010.06.006","volume":"73","author":"S Mathivanan","year":"2010","unstructured":"Mathivanan S, Ji H, Simpson RJ (2010) Exosomes: extracellular organelles important in intercellular communication. J Proteomics 73(10):1907\u20131920","journal-title":"J Proteomics"},{"key":"4484_CR12","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/659890","volume":"2015","author":"K Kang","year":"2015","unstructured":"Kang K, Ma R, Cai W, Huang W, Paul C, Liang J, Wang Y, Zhao T, Kim HW, Xu M et al (2015) Exosomes secreted from CXCR4 overexpressing mesenchymal stem cells promote cardioprotection via Akt signaling pathway following myocardial infarction. Stem Cells Int 2015:659890","journal-title":"Stem Cells Int"},{"key":"4484_CR13","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.taap.2018.09.037","volume":"360","author":"J Yuan","year":"2018","unstructured":"Yuan J, Zhang S, Zhang Y (2018) Nrf1 is paved as a new strategic avenue to prevent and treat cancer, neurodegenerative and other diseases. Toxicol Appl Pharmacol 360:273\u2013283","journal-title":"Toxicol Appl Pharmacol"},{"key":"4484_CR14","doi-asserted-by":"publisher","first-page":"39709","DOI":"10.1038\/srep39709","volume":"6","author":"MM Falco","year":"2016","unstructured":"Falco MM, Bleda M, Carbonell-Caballero J, Dopazo J (2016) The pan-cancer pathological regulatory landscape. Sci Rep 6:39709","journal-title":"Sci Rep"},{"issue":"11","key":"4484_CR15","doi-asserted-by":"publisher","first-page":"2777","DOI":"10.1007\/s00432-020-03320-9","volume":"146","author":"J Ramos","year":"2020","unstructured":"Ramos J, Yoo C, Felty Q, Gong Z, Liuzzi JP, Poppiti R, Thakur IS, Goel R, Vaid AK, Komotar RJ et al (2020) Sensitivity to differential NRF1 gene signatures contributes to breast cancer disparities. J Cancer Res Clin Oncol 146(11):2777\u20132815","journal-title":"J Cancer Res Clin Oncol"},{"issue":"9","key":"4484_CR16","first-page":"5472","volume":"11","author":"H Huang","year":"2019","unstructured":"Huang H, Ni H, Ma K, Zou J (2019) ANGPTL2 regulates autophagy through the MEK\/ERK\/Nrf-1 pathway and affects the progression of renal fibrosis in diabetic nephropathy. Am J Transl Res 11(9):5472\u20135486","journal-title":"Am J Transl Res"},{"issue":"2","key":"4484_CR17","doi-asserted-by":"publisher","first-page":"874","DOI":"10.3892\/etm.2021.10306","volume":"22","author":"L Wang","year":"2021","unstructured":"Wang L, Yuan X, Lian L, Guo H, Zhang H, Zhang M (2021) Knockdown of lncRNA NORAD inhibits the proliferation, inflammation and fibrosis of human mesangial cells under high-glucose conditions by regulating the miR-485\/NRF1 axis. Exp Ther Med 22(2):874","journal-title":"Exp Ther Med"},{"key":"4484_CR18","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.bcp.2015.09.012","volume":"102","author":"I Koeck","year":"2016","unstructured":"Koeck I, Burkhard FC, Monastyrskaya K (2016) Activation of common signaling pathways during remodeling of the heart and the bladder. Biochem Pharmacol 102:7\u201319","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"4484_CR19","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1111\/j.1442-2042.2012.03217.x","volume":"20","author":"YS Song","year":"2013","unstructured":"Song YS, Lee HJ, Doo SW, An J, Kim SU (2013) Enhanced angiogenesis and relaxation of bladder as early response to bladder outlet obstruction. Int J Urol 20(1):116\u2013122","journal-title":"Int J Urol"},{"issue":"5","key":"4484_CR20","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/j.jpedsurg.2004.01.030","volume":"39","author":"SY Lee","year":"2004","unstructured":"Lee SY, Chuang JH, Huang CC, Chou MH, Wu CL, Chen CM, Hsieh CS, Chen CL (2004) Identification of transforming growth factors actively transcribed during the progress of liver fibrosis in biliary atresia. J Pediatr Surg 39(5):702\u2013708","journal-title":"J Pediatr Surg"},{"issue":"2","key":"4484_CR21","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","volume":"136","author":"DP Bartel","year":"2009","unstructured":"Bartel DP (2009) MicroRNAs: target recognition and regulatory functions. Cell 136(2):215\u2013233","journal-title":"Cell"},{"issue":"3","key":"4484_CR22","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/nrd.2016.246","volume":"16","author":"R Rupaimoole","year":"2017","unstructured":"Rupaimoole R, Slack FJ (2017) MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Nat Rev Drug Discov 16(3):203\u2013222","journal-title":"Nat Rev Drug Discov"},{"issue":"2","key":"4484_CR23","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.cellsig.2014.11.001","volume":"27","author":"LJ Duan","year":"2015","unstructured":"Duan LJ, Qi J, Kong XJ, Huang T, Qian XQ, Xu D, Liang JH, Kang J (2015) MiR-133 modulates TGF-beta1-induced bladder smooth muscle cell hypertrophic and fibrotic response: implication for a role of microRNA in bladder wall remodeling caused by bladder outlet obstruction. Cell Signal 27(2):215\u2013227","journal-title":"Cell Signal"},{"key":"4484_CR24","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.biocel.2015.06.005","volume":"65","author":"X Zhao","year":"2015","unstructured":"Zhao X, Wang K, Hu F, Qian C, Guan H, Feng K, Zhou Y, Chen Z (2015) MicroRNA-101 protects cardiac fibroblasts from hypoxia-induced apoptosis via inhibition of the TGF-beta signaling pathway. Int J Biochem Cell Biol 65:155\u2013164","journal-title":"Int J Biochem Cell Biol"},{"key":"4484_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biomaterials.2015.03.029","volume":"55","author":"J Guan","year":"2015","unstructured":"Guan J, Zhang J, Guo S, Zhu H, Zhu Z, Li H, Wang Y, Zhang C, Chang J (2015) Human urine-derived stem cells can be induced into osteogenic lineage by silicate bioceramics via activation of the Wnt\/beta-catenin signaling pathway. Biomaterials 55:1\u201311","journal-title":"Biomaterials"},{"issue":"3","key":"4484_CR26","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1159\/000490214","volume":"47","author":"Q Zhu","year":"2018","unstructured":"Zhu Q, Li Q, Niu X, Zhang G, Ling X, Zhang J, Wang Y, Deng Z (2018) Extracellular vesicles secreted by human urine-derived stem cells promote ischemia repair in a mouse model of hind-limb ischemia. Cell Physiol Biochem 47(3):1181\u20131192","journal-title":"Cell Physiol Biochem"},{"key":"4484_CR27","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14558","author":"YR Duan","year":"2019","unstructured":"Duan YR, Chen BP, Chen F, Yang SX, Zhu CY, Ma YL, Li Y, Shi J (2019) Exosomal microRNA-16\u20135p from human urine-derived stem cells ameliorates diabetic nephropathy through protection of podocyte. J Cell Mol Med. https:\/\/doi.org\/10.1111\/jcmm.14558","journal-title":"J Cell Mol Med"},{"issue":"4","key":"4484_CR28","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1016\/S0022-5347(17)41846-5","volume":"140","author":"WD Steers","year":"1988","unstructured":"Steers WD, De Groat WC (1988) Effect of bladder outlet obstruction on micturition reflex pathways in the rat. J Urol 140(4):864\u2013871","journal-title":"J Urol"},{"issue":"2","key":"4484_CR29","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/iub.1968","volume":"71","author":"N Wang","year":"2019","unstructured":"Wang N, Duan L, Ding J, Cao Q, Qian S, Shen H, Qi J (2019) MicroRNA-101 protects bladder of BOO from hypoxia-induced fibrosis by attenuating TGF-beta-smad2\/3 signaling. IUBMB Life 71(2):235\u2013243","journal-title":"IUBMB Life"},{"issue":"1","key":"4484_CR30","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1111\/j.1442-2042.2012.03192.x","volume":"20","author":"W Shen","year":"2013","unstructured":"Shen W, Li L, Song B, Li W, Zhou Z, Guo R (2013) Platelet-derived growth factor-BB increases expression of connexin 43 in an extracellular-regulated protein kinase-dependent manner in bladder smooth muscle cells. Int J Urol 20(1):123\u2013130","journal-title":"Int J Urol"},{"issue":"1","key":"4484_CR31","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1002\/nau.2034","volume":"21","author":"F Ma","year":"2002","unstructured":"Ma F, Higashira H, Ukai Y, Hanai T, Kiwamoto H, Park YC, Kurita T (2002) A new enzymic method for the isolation and culture of human bladder body smooth muscle cells. Neurourol Urodyn 21(1):71\u201379","journal-title":"Neurourol Urodyn"},{"key":"4484_CR32","doi-asserted-by":"publisher","DOI":"10.31491\/CSRC.2018.12.024","author":"Z Qiu-li","year":"2018","unstructured":"Qiu-li Z, Wei W (2018) LncRNA-H19 induces retinal m\u00fcller cell apoptosis via MiR-29b\/FOXO4 axis in diabetic retinopathy. Clin Surg Res Commun. https:\/\/doi.org\/10.31491\/CSRC.2018.12.024","journal-title":"Clin Surg Res Commun"},{"issue":"1","key":"4484_CR33","doi-asserted-by":"publisher","first-page":"52","DOI":"10.31491\/APT.2020.03.013","volume":"2","author":"Y Niu","year":"2020","unstructured":"Niu Y, Zhou B, Wan C, wu R, Sun H, Lu D (2020) Down-regulation of miR-181a promotes microglial M1 polarization through increasing expression of NDRG2. Aging Pathobiol Ther 2(1):52\u201357","journal-title":"Aging Pathobiol Ther"},{"issue":"1","key":"4484_CR34","doi-asserted-by":"publisher","first-page":"17","DOI":"10.31491\/APT.2019.12.004","volume":"1","author":"B Ge","year":"2019","unstructured":"Ge B, Wu H, Shao D, Li S, Li F (2019) Interfering with miR-24 alleviates rotenone-induced dopaminergic neuron injury via enhancing autophagy by upregulating DJ-1. Aging Pathobiol Ther 1(1):17\u201324","journal-title":"Aging Pathobiol Ther"},{"issue":"1","key":"4484_CR35","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.yexcr.2016.09.005","volume":"349","author":"PF Hsieh","year":"2016","unstructured":"Hsieh PF, Liu SF, Hung TJ, Hung CY, Liu GZ, Chuang LY, Chen MF, Wang JL, Shi MD, Hsu CH et al (2016) Elucidation of the therapeutic role of mitochondrial biogenesis transducers NRF-1 in the regulation of renal fibrosis. Exp Cell Res 349(1):23\u201331","journal-title":"Exp Cell Res"},{"issue":"1","key":"4484_CR36","doi-asserted-by":"publisher","first-page":"7867","DOI":"10.1038\/s41598-017-08384-1","volume":"7","author":"DW Wei","year":"2017","unstructured":"Wei DW, Gui LS, Raza SHA, Zhang S, Khan R, Wang L, Guo HF, Zan LS (2017) NRF1 and ZSCAN10 bind to the promoter region of the SIX1 gene and their effects body measurements in Qinchuan cattle. Sci Rep 7(1):7867","journal-title":"Sci Rep"},{"issue":"1","key":"4484_CR37","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.bbrc.2017.03.002","volume":"486","author":"JS Joseph","year":"2017","unstructured":"Joseph JS, Ayeleso AO, Mukwevho E (2017) Exercise increases hyper-acetylation of histones on the Cis-element of NRF-1 binding to the Mef2a promoter: Implications on type 2 diabetes. Biochem Biophys Res Commun 486(1):83\u201387","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"4484_CR38","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2017.98","volume":"49","author":"JW Lv","year":"2017","unstructured":"Lv JW, Wen W, Jiang C, Fu QB, Gu YJ, Lv TT, Li ZD, Xue W (2017) Inhibition of microRNA-214 promotes epithelial-mesenchymal transition process and induces interstitial cystitis in postmenopausal women by upregulating Mfn2. Exp Mol Med 49(7):e357","journal-title":"Exp Mol Med"},{"issue":"5","key":"4484_CR39","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1016\/j.juro.2015.12.068","volume":"195","author":"FM Hughes Jr","year":"2016","unstructured":"Hughes FM Jr, Hill HM, Wood CM, Edmondson AT, Dumas A, Foo WC, Oelsen JM, Rac G, Purves JT (2016) The NLRP3 inflammasome mediates inflammation produced by bladder outlet obstruction. J Urol 195(5):1598\u20131605","journal-title":"J Urol"},{"issue":"1","key":"4484_CR40","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1002\/nau.21219","volume":"31","author":"J Zeng","year":"2012","unstructured":"Zeng J, Xie K, Jiang C, Mo J, Lindstrom S (2012) Bladder mechanoreceptor changes after artificial bladder outlet obstruction in the anesthetized rat. Neurourol Urodyn 31(1):178\u2013184","journal-title":"Neurourol Urodyn"},{"key":"4484_CR41","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s12894-015-0036-3","volume":"15","author":"SM Yuk","year":"2015","unstructured":"Yuk SM, Shin JH, Song KH, Na YG, Lim JS, Sul CK (2015) Expression of brain derived-neurotrophic factor and granulocyte-colony stimulating factor in the urothelium: relation with voiding function. BMC Urol 15:37","journal-title":"BMC Urol"},{"issue":"7","key":"4484_CR42","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.3727\/096368914X682125","volume":"24","author":"HJ Lee","year":"2015","unstructured":"Lee HJ, An J, Doo SW, Kim JH, Choi SS, Lee SR, Park SW, Song YS, Kim SU (2015) Improvement in spinal cord injury-induced bladder fibrosis using mesenchymal stem cell transplantation into the bladder wall. Cell Transplant 24(7):1253\u20131263","journal-title":"Cell Transplant"},{"issue":"1","key":"4484_CR43","doi-asserted-by":"publisher","first-page":"5270","DOI":"10.1038\/s41467-021-25653-w","volume":"12","author":"M Cui","year":"2021","unstructured":"Cui M, Atmanli A, Morales MG, Tan W, Chen K, Xiao X, Xu L, Liu N, Bassel-Duby R, Olson EN (2021) Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance. Nat Commun 12(1):5270","journal-title":"Nat Commun"},{"issue":"2","key":"4484_CR44","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1007\/s11626-019-00419-3","volume":"56","author":"M Yang","year":"2020","unstructured":"Yang M, Zhang J, Jin X, Li C, Zhou G, Feng J (2020) NRF1-enhanced miR-4458 alleviates cardiac hypertrophy through releasing TTP-inhibited TFAM. In Vitro Cell Dev Biol Anim 56(2):120\u2013128","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"4484_CR45","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.atherosclerosis.2020.02.001","volume":"297","author":"H Chong","year":"2020","unstructured":"Chong H, Wei Z, Na M, Sun G, Zheng S, Zhu X, Xue Y, Zhou Q, Guo S, Xu J et al (2020) The PGC-1alpha\/NRF1\/miR-378a axis protects vascular smooth muscle cells from FFA-induced proliferation, migration and inflammation in atherosclerosis. Atherosclerosis 297:136\u2013145","journal-title":"Atherosclerosis"},{"issue":"1","key":"4484_CR46","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1186\/s12894-020-00765-5","volume":"20","author":"B Liu","year":"2020","unstructured":"Liu B, Ding Y, Li P, Wang T, He S, Jia Z, Yang J (2020) MicroRNA-219c-5p regulates bladder fibrosis by targeting FN1. BMC Urol 20(1):193","journal-title":"BMC Urol"},{"issue":"5","key":"4484_CR47","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1007\/s00192-020-04593-x","volume":"32","author":"Y Hou","year":"2021","unstructured":"Hou Y, Li H, Huo W (2021) MicroRNA-495 alleviates ulcerative interstitial cystitis via inactivating the JAK-STAT signaling pathway by inhibiting JAK3. Int Urogynecol J 32(5):1253\u20131263","journal-title":"Int Urogynecol J"},{"issue":"1","key":"4484_CR48","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1186\/s13046-019-1262-4","volume":"38","author":"X Man","year":"2019","unstructured":"Man X, Piao C, Lin X, Kong C, Cui X, Jiang Y (2019) USP13 functions as a tumor suppressor by blocking the NF-kB-mediated PTEN downregulation in human bladder cancer. J Exp Clin Cancer Res 38(1):259","journal-title":"J Exp Clin Cancer Res"},{"issue":"1","key":"4484_CR49","doi-asserted-by":"publisher","first-page":"10204","DOI":"10.1038\/s41598-021-89535-3","volume":"11","author":"M von Siebenthal","year":"2021","unstructured":"von Siebenthal M, Besic M, Gheinani AH, Akshay A, Lizun-Platoni S, Kunz N, Burkhard FC, Monastyrskaya K (2021) Urinary miRNA profiles discriminate between obstruction-induced bladder dysfunction and healthy controls. Sci Rep 11(1):10204","journal-title":"Sci Rep"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-022-04484-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-022-04484-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-022-04484-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T05:54:43Z","timestamp":1700891683000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-022-04484-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,7]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["4484"],"URL":"https:\/\/doi.org\/10.1007\/s11010-022-04484-3","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,7]]},"assertion":[{"value":"31 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have not disclosed any competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}