{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:38:16Z","timestamp":1783442296176,"version":"3.54.6"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1007\/s11010-022-04574-2","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T15:10:23Z","timestamp":1665069023000},"page":"981-989","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["STAT-3 signaling role in an experimental model of nephropathy induced by doxorubicin"],"prefix":"10.1007","volume":"478","author":[{"given":"Thabata Caroline","family":"de Oliveira Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Gabrielle Gomes","family":"Coutinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halison Pereira","family":"Dos Santos Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo M. S.","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Augusto Lavezzo","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo C\u00e2ndido","family":"de Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora Tavares","family":"Resende e Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Fernandez","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6056-724X","authenticated-orcid":false,"given":"Rafael Luiz","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,6]]},"reference":[{"key":"4574_CR1","doi-asserted-by":"publisher","first-page":"90","DOI":"10.5414\/cnp61090","volume":"61","author":"M Bahiense-Oliveira","year":"2004","unstructured":"Bahiense-Oliveira M, Saldanha LB, Mota EL, Penna DO, Barros RT, Romao-Junior JE (2004) Primary glomerular diseases in Brazil (1979\u20131999): is the frequency of focal and segmental glomerulosclerosis increasing? Clin Nephrol 61:90\u201397. https:\/\/doi.org\/10.5414\/cnp61090","journal-title":"Clin Nephrol"},{"key":"4574_CR2","doi-asserted-by":"publisher","first-page":"399","DOI":"10.2215\/CJN.06100612","volume":"8","author":"VD D'Agati","year":"2013","unstructured":"D\u2019Agati VD, Alster JM, Jennette JC, Thomas DB, Pullman J, Savino DA, Cohen AH, Gipson DS, Gassman JJ, Radeva MK, Moxey-Mims MM, Friedman AL, Kaskel FJ, Trachtman H, Alpers CE, Fogo AB, Greene TH, Nast CC (2013) Association of histologic variants in FSGS clinical trial with presenting features and outcomes. Clin J Am Soc Nephrol 8:399\u2013406. https:\/\/doi.org\/10.2215\/CJN.06100612","journal-title":"Clin J Am Soc Nephrol"},{"key":"4574_CR3","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1093\/ndt\/gfp355","volume":"25","author":"MG Polito","year":"2010","unstructured":"Polito MG, de Moura LA, Kirsztajn GM (2010) An overview on frequency of renal biopsy diagnosis in Brazil: clinical and pathological patterns based on 9,617 native kidney biopsies. Nephrol Dial Transplant 25:490\u2013496. https:\/\/doi.org\/10.1093\/ndt\/gfp355","journal-title":"Nephrol Dial Transplant"},{"key":"4574_CR4","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1159\/000508099","volume":"144","author":"A Shabaka","year":"2020","unstructured":"Shabaka A, Tato Ribera A, Fernandez-Juarez G (2020) Focal segmental glomerulosclerosis: state-of-the-art and clinical perspective. Nephron 144:413\u2013427. https:\/\/doi.org\/10.1159\/000508099","journal-title":"Nephron"},{"key":"4574_CR5","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1016\/j.mayocp.2017.09.011","volume":"92","author":"MS Hommos","year":"2017","unstructured":"Hommos MS, De Vriese AS, Alexander MP, Sethi S, Vaughan L, Zand L, Bharucha K, Lepori N, Rule AD, Fervenza FC (2017) The incidence of primary vs secondary focal segmental glomerulosclerosis: a clinicopathologic study. Mayo Clin Proc 92:1772\u20131781. https:\/\/doi.org\/10.1016\/j.mayocp.2017.09.011","journal-title":"Mayo Clin Proc"},{"key":"4574_CR6","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s40620-016-0333-2","volume":"29","author":"A Angioi","year":"2016","unstructured":"Angioi A, Pani A (2016) FSGS: from pathogenesis to the histological lesion. J Nephrol 29:517\u2013523. https:\/\/doi.org\/10.1007\/s40620-016-0333-2","journal-title":"J Nephrol"},{"key":"4574_CR7","doi-asserted-by":"publisher","first-page":"4632768","DOI":"10.1155\/2016\/4632768","volume":"2016","author":"B Sprangers","year":"2016","unstructured":"Sprangers B, Meijers B, Appel G (2016) FSGS: diagnosis and diagnostic work-up. Biomed Res Int 2016:4632768. https:\/\/doi.org\/10.1155\/2016\/4632768","journal-title":"Biomed Res Int"},{"key":"4574_CR8","doi-asserted-by":"publisher","first-page":"247","DOI":"10.2215\/CJN.08970719","volume":"15","author":"A Uffing","year":"2020","unstructured":"Uffing A, Perez-Saez MJ, Mazzali M, Manfro RC, Bauer AC, de Sottomaior DF, O\u2019Shaughnessy MM, Cheng XS, Chin KK, Ventura CG, Agena F, David-Neto E, Mansur JB, Kirsztajn GM, Tedesco-Silva H Jr, Neto GMV, Arias-Cabrales C, Buxeda A, Bugnazet M, Jouve T, Malvezzi P, Akalin E, Alani O, Agrawal N, La Manna G, Comai G, Bini C, Muhsin SA, Riella MC, Hokazono SR, Farouk SS, Haverly M, Mothi SS, Berger SP, Cravedi P, Riella LV (2020) Recurrence of FSGS after kidney transplantation in adults. Clin J Am Soc Nephrol 15:247\u2013256. https:\/\/doi.org\/10.2215\/CJN.08970719","journal-title":"Clin J Am Soc Nephrol"},{"key":"4574_CR9","doi-asserted-by":"publisher","first-page":"171","DOI":"10.2215\/CJN.14841219","volume":"15","author":"RA Lafayette","year":"2020","unstructured":"Lafayette RA (2020) Facing the vexing problem of recurrent FSGS after kidney transplantation. Clin J Am Soc Nephrol 15:171\u2013173. https:\/\/doi.org\/10.2215\/CJN.14841219","journal-title":"Clin J Am Soc Nephrol"},{"key":"4574_CR10","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.2215\/CJN.06720810","volume":"5","author":"C Ponticelli","year":"2010","unstructured":"Ponticelli C, Glassock RJ (2010) Posttransplant recurrence of primary glomerulonephritis. Clin J Am Soc Nephrol 5:2363\u20132372. https:\/\/doi.org\/10.2215\/CJN.06720810","journal-title":"Clin J Am Soc Nephrol"},{"key":"4574_CR11","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1111\/j.1440-1797.2010.01383.x","volume":"16","author":"VW Lee","year":"2011","unstructured":"Lee VW, Harris DC (2011) Adriamycin nephropathy: a model of focal segmental glomerulosclerosis. Nephrology (Carlton) 16:30\u201338. https:\/\/doi.org\/10.1111\/j.1440-1797.2010.01383.x","journal-title":"Nephrology (Carlton)"},{"key":"4574_CR12","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1038\/ki.1986.28","volume":"29","author":"S Okuda","year":"1986","unstructured":"Okuda S, Oh Y, Tsuruda H, Onoyama K, Fujimi S, Fujishima M (1986) Adriamycin-induced nephropathy as a model of chronic progressive glomerular disease. Kidney Int 29:502\u2013510. https:\/\/doi.org\/10.1038\/ki.1986.28","journal-title":"Kidney Int"},{"key":"4574_CR13","doi-asserted-by":"publisher","first-page":"F76","DOI":"10.1152\/ajprenal.00331.2018","volume":"316","author":"L Xie","year":"2019","unstructured":"Xie L, Koukos G, Barck K, Foreman O, Lee WP, Brendza R, Eastham-Anderson J, McKenzie BS, Peterson A, Carano RAD (2019) Micro-CT imaging and structural analysis of glomeruli in a model of Adriamycin-induced nephropathy. Am J Physiol Renal Physiol 316:F76\u2013F89. https:\/\/doi.org\/10.1152\/ajprenal.00331.2018","journal-title":"Am J Physiol Renal Physiol"},{"key":"4574_CR14","doi-asserted-by":"publisher","first-page":"28","DOI":"10.5812\/nephropathol.8959","volume":"2","author":"S Shakeel","year":"2013","unstructured":"Shakeel S, Mubarak M, Kazi JI, Jafry N, Ahmed E (2013) Frequency and clinicopathological characteristics of variants of primary focal segmental glomerulosclerosis in adults presenting with nephrotic syndrome. J Nephropathol 2:28\u201335. https:\/\/doi.org\/10.5812\/nephropathol.8959","journal-title":"J Nephropathol"},{"key":"4574_CR15","first-page":"322","volume":"64","author":"S Shakeel","year":"2014","unstructured":"Shakeel S, Mubarak M, Kazi JI (2014) Frequency and clinicopathological correlations of histopathological variants of idiopathic focal segmental glomerulosclerosis in nephrotic adolescents. J Pak Med Assoc 64:322\u2013326","journal-title":"J Pak Med Assoc"},{"key":"4574_CR16","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1053\/snep.2003.50015","volume":"23","author":"AB Fogo","year":"2003","unstructured":"Fogo AB (2003) Animal models of FSGS: lessons for pathogenesis and treatment. Semin Nephrol 23:161\u2013171. https:\/\/doi.org\/10.1053\/snep.2003.50015","journal-title":"Semin Nephrol"},{"key":"4574_CR17","doi-asserted-by":"publisher","first-page":"2974","DOI":"10.1681\/ASN.2006040377","volume":"17","author":"M Abbate","year":"2006","unstructured":"Abbate M, Zoja C, Remuzzi G (2006) How does proteinuria cause progressive renal damage? J Am Soc Nephrol 17:2974\u20132984. https:\/\/doi.org\/10.1681\/ASN.2006040377","journal-title":"J Am Soc Nephrol"},{"key":"4574_CR18","doi-asserted-by":"publisher","first-page":"4179","DOI":"10.1111\/jcmm.14304","volume":"23","author":"Y Li","year":"2019","unstructured":"Li Y, Zhou H, Li Y, Han L, Song M, Chen F, Shang G, Wang D, Wang Z, Zhang W, Zhong M (2019) PTPN2 improved renal injury and fibrosis by suppressing STAT-induced inflammation in early diabetic nephropathy. J Cell Mol Med 23:4179\u20134195. https:\/\/doi.org\/10.1111\/jcmm.14304","journal-title":"J Cell Mol Med"},{"key":"4574_CR19","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1007\/s10753-019-01120-z","volume":"43","author":"Q Liu","year":"2020","unstructured":"Liu Q, Liang X, Liang M, Qin R, Qin F, Wang X (2020) Ellagic acid ameliorates renal ischemic-reperfusion injury through NOX4\/JAK\/STAT signaling pathway. Inflammation 43:298\u2013309. https:\/\/doi.org\/10.1007\/s10753-019-01120-z","journal-title":"Inflammation"},{"key":"4574_CR20","doi-asserted-by":"publisher","first-page":"3837","DOI":"10.1111\/jcmm.14973","volume":"24","author":"Y Liu","year":"2020","unstructured":"Liu Y, Feng Q, Miao J, Wu Q, Zhou S, Shen W, Feng Y, Hou FF, Liu Y, Zhou L (2020) C-X-C motif chemokine receptor 4 aggravates renal fibrosis through activating JAK\/STAT\/GSK3beta\/beta-catenin pathway. J Cell Mol Med 24:3837\u20133855. https:\/\/doi.org\/10.1111\/jcmm.14973","journal-title":"J Cell Mol Med"},{"key":"4574_CR21","doi-asserted-by":"publisher","first-page":"973","DOI":"10.2215\/CJN.11010919","volume":"15","author":"J Tao","year":"2020","unstructured":"Tao J, Mariani L, Eddy S, Maecker H, Kambham N, Mehta K, Hartman J, Wang W, Kretzler M, Lafayette RA (2020) JAK-STAT activity in peripheral blood cells and kidney tissue in IgA nephropathy. Clin J Am Soc Nephrol 15:973\u2013982. https:\/\/doi.org\/10.2215\/CJN.11010919","journal-title":"Clin J Am Soc Nephrol"},{"key":"4574_CR22","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1002\/jcb.25058","volume":"116","author":"JS Huang","year":"2015","unstructured":"Huang JS, Lee YH, Chuang LY, Guh JY, Hwang JY (2015) Cinnamaldehyde and nitric oxide attenuate advanced glycation end products-induced the Jak\/STAT signaling in human renal tubular cells. J Cell Biochem 116:1028\u20131038. https:\/\/doi.org\/10.1002\/jcb.25058","journal-title":"J Cell Biochem"},{"key":"4574_CR23","doi-asserted-by":"publisher","first-page":"F1000","DOI":"10.1152\/ajprenal.00482.2015","volume":"310","author":"R O'Leary","year":"2016","unstructured":"O\u2019Leary R, Penrose H, Miyata K, Satou R (2016) Macrophage-derived IL-6 contributes to ANG II-mediated angiotensinogen stimulation in renal proximal tubular cells. Am J Physiol Renal Physiol 310:F1000\u2013F1007. https:\/\/doi.org\/10.1152\/ajprenal.00482.2015","journal-title":"Am J Physiol Renal Physiol"},{"key":"4574_CR24","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-020-01283-0","author":"B Zhang","year":"2020","unstructured":"Zhang B, Guo Z, Lai S, Chen H (2020) Interference with miR-210 alleviated renal injury in septic rats by inhibiting JAK-STAT pathway. Inflammation. https:\/\/doi.org\/10.1007\/s10753-020-01283-0","journal-title":"Inflammation"},{"key":"4574_CR25","doi-asserted-by":"publisher","first-page":"2585","DOI":"10.3892\/ol.2020.11394","volume":"19","author":"Y Gu","year":"2020","unstructured":"Gu Y, Mohammad IS, Liu Z (2020) Overview of the STAT-3 signaling pathway in cancer and the development of specific inhibitors. Oncol Lett 19:2585\u20132594. https:\/\/doi.org\/10.3892\/ol.2020.11394","journal-title":"Oncol Lett"},{"key":"4574_CR26","doi-asserted-by":"publisher","first-page":"105151","DOI":"10.1016\/j.ejps.2019.105151","volume":"143","author":"WA Abualsunun","year":"2020","unstructured":"Abualsunun WA, Sahin C, Cummins CL, Piquette-Miller M (2020) Essential role of STAT-3 dependent NF-kappaB activation on IL-6-mediated downregulation of hepatic transporters. Eur J Pharm Sci 143:105151. https:\/\/doi.org\/10.1016\/j.ejps.2019.105151","journal-title":"Eur J Pharm Sci"},{"key":"4574_CR27","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1002\/kjm2.12159","volume":"36","author":"YL Yang","year":"2020","unstructured":"Yang YL, Liu P, Li D, Yang Q, Li B, Jiang XJ (2020) Stat-3 signaling promotes cell proliferation and metastasis of gastric cancer through PDCD4 downregulation. Kaohsiung J Med Sci 36:244\u2013249. https:\/\/doi.org\/10.1002\/kjm2.12159","journal-title":"Kaohsiung J Med Sci"},{"key":"4574_CR28","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/ki.2010.158","volume":"78","author":"PY Chuang","year":"2010","unstructured":"Chuang PY, He JC (2010) JAK\/STAT signaling in renal diseases. Kidney Int 78:231\u2013234. https:\/\/doi.org\/10.1038\/ki.2010.158","journal-title":"Kidney Int"},{"key":"4574_CR29","doi-asserted-by":"publisher","first-page":"3690","DOI":"10.1681\/ASN.2015091014","volume":"27","author":"F Bienaime","year":"2016","unstructured":"Bienaime F, Muorah M, Yammine L, Burtin M, Nguyen C, Baron W, Garbay S, Viau A, Broueilh M, Blanc T, Peters D, Poli V, Anglicheau D, Friedlander G, Pontoglio M, Gallazzini M, Terzi F (2016) Stat3 controls tubulointerstitial communication during CKD. J Am Soc Nephrol 27:3690\u20133705. https:\/\/doi.org\/10.1681\/ASN.2015091014","journal-title":"J Am Soc Nephrol"},{"key":"4574_CR30","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/ki.2010.154","volume":"78","author":"M Pang","year":"2010","unstructured":"Pang M, Ma L, Gong R, Tolbert E, Mao H, Ponnusamy M, Chin YE, Yan H, Dworkin LD, Zhuang S (2010) A novel STAT3 inhibitor, S3I\u2013201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy. Kidney Int 78:257\u2013268. https:\/\/doi.org\/10.1038\/ki.2010.154","journal-title":"Kidney Int"},{"key":"4574_CR31","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1681\/ASN.2007111205","volume":"20","author":"M Jeansson","year":"2009","unstructured":"Jeansson M, Bjorck K, Tenstad O, Haraldsson B (2009) Adriamycin alters glomerular endothelium to induce proteinuria. J Am Soc Nephrol 20:114\u2013122. https:\/\/doi.org\/10.1681\/ASN.2007111205","journal-title":"J Am Soc Nephrol"},{"key":"4574_CR32","doi-asserted-by":"publisher","first-page":"2290","DOI":"10.2353\/ajpath.2010.100263","volume":"177","author":"AV Cybulsky","year":"2010","unstructured":"Cybulsky AV, Takano T, Papillon J, Guillemette J, Herzenberg AM, Kennedy CR (2010) Podocyte injury and albuminuria in mice with podocyte-specific overexpression of the Ste20-like kinase, SLK. Am J Pathol 177:2290\u20132299. https:\/\/doi.org\/10.2353\/ajpath.2010.100263","journal-title":"Am J Pathol"},{"key":"4574_CR33","doi-asserted-by":"publisher","first-page":"645","DOI":"10.3389\/fimmu.2016.00645","volume":"7","author":"DC de Almeida","year":"2016","unstructured":"de Almeida DC, Bassi EJ, Azevedo H, Anderson L, Origassa CS, Cenedeze MA, de Andrade-Oliveira V, Felizardo RJ, da Silva RC, Hiyane MI, Semedo P, Dos Reis MA, Moreira-Filho CA, Verjovski-Almeida S, Pacheco-Silva A, Camara NO (2016) A regulatory miRNA-mRNA network is associated with tissue repair induced by mesenchymal stromal cells in acute kidney injury. Front Immunol 7:645. https:\/\/doi.org\/10.3389\/fimmu.2016.00645","journal-title":"Front Immunol"},{"key":"4574_CR34","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.imbio.2016.10.001","volume":"222","author":"SF Ahmad","year":"2017","unstructured":"Ahmad SF, Ansari MA, Nadeem A, Zoheir KMA, Bakheet SA, Alsaad AMS, Al-Shabanah OA, Attia SM (2017) STA-21, a STAT-3 inhibitor, attenuates the development and progression of inflammation in collagen antibody-induced arthritis. Immunobiology 222:206\u2013217. https:\/\/doi.org\/10.1016\/j.imbio.2016.10.001","journal-title":"Immunobiology"},{"key":"4574_CR35","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1096\/fj.15-273953","volume":"30","author":"M Pedroza","year":"2016","unstructured":"Pedroza M, Le TT, Lewis K, Karmouty-Quintana H, To S, George AT, Blackburn MR, Tweardy DJ, Agarwal SK (2016) STAT-3 contributes to pulmonary fibrosis through epithelial injury and fibroblast-myofibroblast differentiation. FASEB J 30:129\u2013140. https:\/\/doi.org\/10.1096\/fj.15-273953","journal-title":"FASEB J"},{"key":"4574_CR36","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.2215\/CJN.07170714","volume":"9","author":"KN Campbell","year":"2014","unstructured":"Campbell KN, He JC (2014) Can biomarkers of disease activity guide treatment in FSGS? Clin J Am Soc Nephrol 9:1507\u20131509. https:\/\/doi.org\/10.2215\/CJN.07170714","journal-title":"Clin J Am Soc Nephrol"},{"key":"4574_CR37","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1111\/ajt.12045","volume":"13","author":"P Cravedi","year":"2013","unstructured":"Cravedi P, Kopp JB, Remuzzi G (2013) Recent progress in the pathophysiology and treatment of FSGS recurrence. Am J Transplant 13:266\u2013274. https:\/\/doi.org\/10.1111\/ajt.12045","journal-title":"Am J Transplant"},{"key":"4574_CR38","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1681\/ASN.2012040389","volume":"23","author":"SM Korbet","year":"2012","unstructured":"Korbet SM (2012) Treatment of primary FSGS in adults. J Am Soc Nephrol 23:1769\u20131776. https:\/\/doi.org\/10.1681\/ASN.2012040389","journal-title":"J Am Soc Nephrol"},{"key":"4574_CR39","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1053\/j.ackd.2014.01.010","volume":"21","author":"CB Sethna","year":"2014","unstructured":"Sethna CB, Gipson DS (2014) Treatment of FSGS in children. Adv Chronic Kidney Dis 21:194\u2013199. https:\/\/doi.org\/10.1053\/j.ackd.2014.01.010","journal-title":"Adv Chronic Kidney Dis"},{"key":"4574_CR40","doi-asserted-by":"publisher","first-page":"2502","DOI":"10.1073\/pnas.0409786102","volume":"102","author":"Z Zheng","year":"2005","unstructured":"Zheng Z, Schmidt-Ott KM, Chua S, Foster KA, Frankel RZ, Pavlidis P, Barasch J, D\u2019Agati VD, Gharavi AG (2005) A Mendelian locus on chromosome 16 determines susceptibility to doxorubicin nephropathy in the mouse. Proc Natl Acad Sci USA 102:2502\u20132507. https:\/\/doi.org\/10.1073\/pnas.0409786102","journal-title":"Proc Natl Acad Sci USA"},{"key":"4574_CR41","doi-asserted-by":"publisher","first-page":"e32454","DOI":"10.1371\/journal.pone.0032454","volume":"7","author":"RL Pereira","year":"2012","unstructured":"Pereira RL, Reis VO, Semedo P, Buscariollo BN, Donizetti-Oliveira C, Cenedeze MA, Soares MF, Pacheco-Silva A, Savage PB, Camara NO, Keller AC (2012) Invariant natural killer T cell agonist modulates experimental focal and segmental glomerulosclerosis. PLoS ONE 7:e32454. https:\/\/doi.org\/10.1371\/journal.pone.0032454","journal-title":"PLoS ONE"},{"key":"4574_CR42","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1083\/jcb.201410017","volume":"209","author":"RP Scott","year":"2015","unstructured":"Scott RP, Quaggin SE (2015) Review series: the cell biology of renal filtration. J Cell Biol 209:199\u2013210. https:\/\/doi.org\/10.1083\/jcb.201410017","journal-title":"J Cell Biol"},{"key":"4574_CR43","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.coi.2015.02.008","volume":"34","author":"C Garbers","year":"2015","unstructured":"Garbers C, Aparicio-Siegmund S, Rose-John S (2015) The IL-6\/gp130\/STAT3 signaling axis: recent advances towards specific inhibition. Curr Opin Immunol 34:75\u201382. https:\/\/doi.org\/10.1016\/j.coi.2015.02.008","journal-title":"Curr Opin Immunol"},{"key":"4574_CR44","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1038\/nrrheum.2014.127","volume":"10","author":"LH Calabrese","year":"2014","unstructured":"Calabrese LH, Rose-John S (2014) IL-6 biology: implications for clinical targeting in rheumatic disease. Nat Rev Rheumatol 10:720\u2013727. https:\/\/doi.org\/10.1038\/nrrheum.2014.127","journal-title":"Nat Rev Rheumatol"},{"key":"4574_CR45","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/ni.3153","volume":"16","author":"CA Hunter","year":"2015","unstructured":"Hunter CA, Jones SA (2015) IL-6 as a keystone cytokine in health and disease. Nat Immunol 16:448\u2013457. https:\/\/doi.org\/10.1038\/ni.3153","journal-title":"Nat Immunol"},{"key":"4574_CR46","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1007\/s13730-017-0276-z","volume":"6","author":"S Isobe","year":"2017","unstructured":"Isobe S, Ohashi N, Katahashi N, Ishigaki S, Tsuji N, Tsuji T, Kato A, Fujigaki Y, Shimizu A, Yasuda H (2017) Focal segmental glomerulosclerosis associated with cutaneous and systemic plasmacytosis. CEN Case Rep 6:206\u2013209. https:\/\/doi.org\/10.1007\/s13730-017-0276-z","journal-title":"CEN Case Rep"},{"key":"4574_CR47","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1038\/ki.1993.317","volume":"44","author":"K Yoshioka","year":"1993","unstructured":"Yoshioka K, Takemura T, Murakami K, Okada M, Yagi K, Miyazato H, Matsushima K, Maki S (1993) In situ expression of cytokines in IgA nephritis. Kidney Int 44:825\u2013833. https:\/\/doi.org\/10.1038\/ki.1993.317","journal-title":"Kidney Int"},{"key":"4574_CR48","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3389\/fimmu.2014.00058","volume":"5","author":"B Carow","year":"2014","unstructured":"Carow B, Rottenberg ME (2014) SOCS3, a major regulator of infection and inflammation. Front Immunol 5:58. https:\/\/doi.org\/10.3389\/fimmu.2014.00058","journal-title":"Front Immunol"},{"key":"4574_CR49","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1007\/978-981-13-8871-2_18","volume":"1165","author":"XM Meng","year":"2019","unstructured":"Meng XM (2019) Inflammatory mediators and renal fibrosis. Adv Exp Med Biol 1165:381\u2013406. https:\/\/doi.org\/10.1007\/978-981-13-8871-2_18","journal-title":"Adv Exp Med Biol"},{"key":"4574_CR50","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.kint.2018.05.022","volume":"94","author":"J Tao","year":"2018","unstructured":"Tao J, Mariani L, Eddy S, Maecker H, Kambham N, Mehta K, Hartman J, Wang W, Kretzler M, Lafayette RA (2018) JAK-STAT signaling is activated in the kidney and peripheral blood cells of patients with focal segmental glomerulosclerosis. Kidney Int 94:795\u2013808. https:\/\/doi.org\/10.1016\/j.kint.2018.05.022","journal-title":"Kidney Int"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-022-04574-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-022-04574-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-022-04574-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T17:10:58Z","timestamp":1682356258000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-022-04574-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,6]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["4574"],"URL":"https:\/\/doi.org\/10.1007\/s11010-022-04574-2","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,6]]},"assertion":[{"value":"28 January 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All experimental procedures were carried out following the ethical principles established by the Experimental Brazilian Council (COBEA) and approved by the local Animal Ethics Committee (protocol n\u00b0957).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}