{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:42:36Z","timestamp":1786981356763,"version":"build-2736575974"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:00:00Z","timestamp":1666656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:00:00Z","timestamp":1666656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["NS103826"],"award-info":[{"award-number":["NS103826"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["NS103826"],"award-info":[{"award-number":["NS103826"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["NS103826"],"award-info":[{"award-number":["NS103826"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["NS103826"],"award-info":[{"award-number":["NS103826"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["NS103826"],"award-info":[{"award-number":["NS103826"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["NS103826"],"award-info":[{"award-number":["NS103826"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["NS103826"],"award-info":[{"award-number":["NS103826"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["NS103826"],"award-info":[{"award-number":["NS103826"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["NS103826"],"award-info":[{"award-number":["NS103826"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["NS103826"],"award-info":[{"award-number":["NS103826"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["NS103826"],"award-info":[{"award-number":["NS103826"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["NS103826"],"award-info":[{"award-number":["NS103826"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["NS103826"],"award-info":[{"award-number":["NS103826"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["NS103826"],"award-info":[{"award-number":["NS103826"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1007\/s11010-022-04589-9","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T09:02:45Z","timestamp":1666688565000},"page":"1231-1244","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Succinate prodrugs as treatment for acute metabolic crisis during fluoroacetate intoxication in the rat"],"prefix":"10.1007","volume":"478","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1779-3532","authenticated-orcid":false,"given":"Sarah","family":"Piel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna I.","family":"Janowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Laurenson","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meagan J.","family":"McManus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle I.","family":"Aronowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr K.","family":"Janowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Starr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan N.","family":"Hook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco M.","family":"Hefti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carly L.","family":"Clayman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eskil","family":"Elm\u00e9r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus J.","family":"Hansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Karlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes K.","family":"Ehinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd J.","family":"Kilbaugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,25]]},"reference":[{"issue":"4","key":"4589_CR1","doi-asserted-by":"publisher","first-page":"213","DOI":"10.2165\/00139709-200625040-00002","volume":"25","author":"AT Proudfoot","year":"2006","unstructured":"Proudfoot AT, Bradberry SM, Vale JA (2006) Sodium fluoroacetate poisoning. Toxicol Rev 25(4):213\u2013219","journal-title":"Toxicol Rev"},{"issue":"2","key":"4589_CR2","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1002\/jat.1118","volume":"26","author":"NV Goncharov","year":"2006","unstructured":"Goncharov NV, Jenkins RO, Radilov AS (2006) Toxicology of fluoroacetate: a review, with possible directions for therapy research. J Appl Toxicol: JAT 26(2):148\u2013161","journal-title":"J Appl Toxicol: JAT"},{"issue":"1","key":"4589_CR3","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/s41467-019-13668-3","volume":"11","author":"I Mart\u00ednez-Reyes","year":"2020","unstructured":"Mart\u00ednez-Reyes I, Chandel NS (2020) Mitochondrial TCA cycle metabolites control physiology and disease. Nat Commun 11(1):102","journal-title":"Nat Commun"},{"issue":"1","key":"4589_CR4","doi-asserted-by":"publisher","first-page":"1568669","DOI":"10.1080\/23312025.2019.1568669","volume":"5","author":"BJ McCranor","year":"2019","unstructured":"McCranor BJ, Young TD, Tressler J, Jennings L, Irwin J, Alli NA et al (2019) The cardiopulmonary effects of sodium fluoroacetate (1080) in Sprague\u2013Dawley rats. Cogent Biol 5(1):1568669","journal-title":"Cogent Biol"},{"issue":"1","key":"4589_CR5","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1111\/nyas.14347","volume":"1479","author":"VE DeLey Cox","year":"2020","unstructured":"DeLey Cox VE, Hartog MA, Pueblo E, Racine M, Jennings L, Tressler J et al (2020) Methylene blue and monosodium glutamate improve neurologic signs after fluoroacetate poisoning. Ann N Y Acad Sci 1479(1):196\u2013209","journal-title":"Ann N Y Acad Sci"},{"key":"4589_CR6","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/B978-0-12-374484-5.00013-4","volume-title":"Handbook of toxicology of chemical warfare agents","author":"N Goncharov","year":"2009","unstructured":"Goncharov N, Glashkina L, Savelieva E, Zinchenko V, Kuznetsov S, Vinokurov M et al (2009) CHAPTER 13 - Fluoroacetate. In: Gupta RC (ed) Handbook of toxicology of chemical warfare agents. Academic Press, San Diego, pp 177\u2013198"},{"key":"4589_CR7","doi-asserted-by":"publisher","first-page":"12317","DOI":"10.1038\/ncomms12317","volume":"7","author":"JK Ehinger","year":"2016","unstructured":"Ehinger JK, Piel S, Ford R, Karlsson M, Sjovall F, Frostner EA et al (2016) Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency. Nat Commun 7:12317","journal-title":"Nat Commun"},{"key":"4589_CR8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15563650.2020.1814316","volume":"59","author":"DH Jang","year":"2021","unstructured":"Jang DH, Piel S, Greenwood JC, Kelly M, Mazandi VM, Ranganathan A et al (2021) Alterations in cerebral and cardiac mitochondrial function in a porcine model of acute carbon monoxide poisoning. Clin Toxicol (Philadelphia, Pa). 59:1\u201314","journal-title":"Clin Toxicol (Philadelphia, Pa)."},{"key":"4589_CR9","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/978-1-61779-382-0_3","volume":"810","author":"D Pesta","year":"2012","unstructured":"Pesta D, Gnaiger E (2012) High-resolution respirometry: OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle. Methods Mol Biol (Clifton, NJ) 810:25\u201358","journal-title":"Methods Mol Biol (Clifton, NJ)"},{"issue":"6","key":"4589_CR10","doi-asserted-by":"publisher","first-page":"e67747","DOI":"10.1371\/journal.pone.0067747","volume":"8","author":"S Morota","year":"2013","unstructured":"Morota S, Manolopoulos T, Eyjolfsson A, Kimblad P-O, Wierup P, Metzsch C et al (2013) Functional and pharmacological characteristics of permeability transition in isolated human heart mitochondria. PloS One 8(6):e67747","journal-title":"PloS One"},{"key":"4589_CR11","unstructured":"Kirzon MV, Time\u012dko VN, Artiushkova VA (1973) Citric acid accumulation in different organs of rabbits and cats with sodium fluoroacetate poisoning. Vopr Med Khimii 19(5):471\u2013475"},{"issue":"2","key":"4589_CR12","doi-asserted-by":"publisher","first-page":"13c","DOI":"10.1042\/bj0930013C","volume":"93","author":"RH Bowman","year":"1964","unstructured":"Bowman RH (1964) Inhibition of citrate metabolism by sodium fluoroacetate in the perfused rat heart and the effect on phosphofructokinase activity and glucose utilization. Biochem J 93(2):13c-c15","journal-title":"Biochem J"},{"issue":"3\u20134","key":"4589_CR13","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1113\/jphysiol.1949.sp004456","volume":"110","author":"P Buffa","year":"1949","unstructured":"Buffa P, Peters RA (1949) The in vivo formation of citrate induced by fluoroacetate and its significance. J Physiol 110(3\u20134):488\u2013500","journal-title":"J Physiol"},{"key":"4589_CR14","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.mito.2016.10.003","volume":"31","author":"M Karlsson","year":"2016","unstructured":"Karlsson M, Ehinger JK, Piel S, Sjovall F, Henriksnas J, Hoglund U et al (2016) Changes in energy metabolism due to acute rotenone-induced mitochondrial complex I dysfunction\u2014an in vivo large animal model. Mitochondrion 31:56\u201362","journal-title":"Mitochondrion"},{"issue":"2","key":"4589_CR15","doi-asserted-by":"publisher","first-page":"C641","DOI":"10.1152\/ajpcell.00222.2006","volume":"292","author":"O Kann","year":"2007","unstructured":"Kann O, Kov\u00e1cs R (2007) Mitochondria and neuronal activity. Am J Physiol Cell Physiol 292(2):C641\u2013C657","journal-title":"Am J Physiol Cell Physiol"},{"issue":"4","key":"4589_CR16","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.neuint.2012.02.013","volume":"61","author":"NM Rowley","year":"2012","unstructured":"Rowley NM, Madsen KK, Schousboe A, Steve WH (2012) Glutamate and GABA synthesis, release, transport and metabolism as targets for seizure control. Neurochem Int 61(4):546\u2013558","journal-title":"Neurochem Int"},{"key":"4589_CR17","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3389\/fnut.2019.00063","volume":"6","author":"NG Norwitz","year":"2019","unstructured":"Norwitz NG, Hu MT, Clarke K (2019) the mechanisms by which the Ketone body d-\u03b2-hydroxybutyrate may improve the multiple cellular pathologies of Parkinson\u2019s disease. Front Nutr 6:63","journal-title":"Front Nutr"},{"key":"4589_CR18","doi-asserted-by":"publisher","first-page":"101395","DOI":"10.1016\/j.redox.2019.101395","volume":"29","author":"P Rojas-Morales","year":"2020","unstructured":"Rojas-Morales P, Pedraza-Chaverri J, Tapia E (2020) Ketone bodies, stress response, and redox homeostasis. Redox Biol 29:101395","journal-title":"Redox Biol"},{"key":"4589_CR19","doi-asserted-by":"publisher","first-page":"171","DOI":"10.3389\/fnmol.2021.732120","volume":"14","author":"D Garc\u00eda-Rodr\u00edguez","year":"2021","unstructured":"Garc\u00eda-Rodr\u00edguez D, Gim\u00e9nez-Cassina A (2021) Ketone bodies in the brain beyond fuel metabolism: from excitability to gene expression and cell signaling. Front Mol Neurosci 14:171","journal-title":"Front Mol Neurosci"},{"issue":"4","key":"4589_CR20","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.ccc.2012.07.001","volume":"28","author":"MM Cartwright","year":"2012","unstructured":"Cartwright MM, Hajja W, Al-Khatib S, Hazeghazam M, Sreedhar D, Li RN et al (2012) Toxigenic and metabolic causes of ketosis and ketoacidotic syndromes. Crit Care Clin 28(4):601\u2013631","journal-title":"Crit Care Clin"},{"issue":"5","key":"4589_CR21","first-page":"427","volume":"32","author":"F Omara","year":"1990","unstructured":"Omara F, Sisodia CS (1990) Evaluation of potential antidotes for sodium fluoroacetate in mice. Vet Hum Toxicol 32(5):427\u2013431","journal-title":"Vet Hum Toxicol"},{"issue":"4","key":"4589_CR22","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1191\/0960327106ht609oa","volume":"25","author":"RC Collicchio-Zuanaze","year":"2006","unstructured":"Collicchio-Zuanaze RC, Sakate M, Schwartz DS, Trezza E, Crocci AJ (2006) Calcium gluconate and sodium succinate for therapy of sodium fluoroacetate experimental intoxication in cats: clinical and electrocardiographic evaluation. Hum Exp Toxicol 25(4):175\u2013182","journal-title":"Hum Exp Toxicol"},{"key":"4589_CR23","first-page":"6612276","volume":"2021","author":"Y Yu","year":"2021","unstructured":"Yu Y, Yu J, Yao R, Wang P, Zhang Y, Xiao J et al (2021) Admission serum ionized and total calcium as new predictors of mortality in patients with cardiogenic shock. Biomed Res Int 2021:6612276","journal-title":"Biomed Res Int"},{"issue":"2","key":"4589_CR24","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/0041-008X(80)90292-6","volume":"56","author":"A Roy","year":"1980","unstructured":"Roy A, Taitelman U, Bursztein S (1980) Evaluation of the role of ionized calcium in sodium fluoroacetate (\u201c1080\u201d) poisoning. Toxicol Appl Pharmacol 56(2):216\u2013220","journal-title":"Toxicol Appl Pharmacol"},{"key":"4589_CR25","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1007\/978-3-642-69083-9_40","volume":"6","author":"U Taitelman","year":"1983","unstructured":"Taitelman U, Roy A, Raikhlin-Eisenkraft B, Hoffer E (1983) The effect of monoacetin and calcium chloride on acid-base balance and survival in experimental sodium fluoroacetate poisoning. Arch Toxicol Suppl 6:222\u20137","journal-title":"Arch Toxicol Suppl"},{"issue":"1","key":"4589_CR26","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1177\/0271678X211042112","volume":"42","author":"A Khellaf","year":"2022","unstructured":"Khellaf A, Garcia NM, Tajsic T, Alam A, Stovell MG, Killen MJ et al (2022) Focally administered succinate improves cerebral metabolism in traumatic brain injury patients with mitochondrial dysfunction. J Cerebral Blood Flow Metabol 42(1):39\u201355","journal-title":"J Cerebral Blood Flow Metabol"},{"issue":"1","key":"4589_CR27","doi-asserted-by":"publisher","first-page":"11140","DOI":"10.1038\/s41598-018-29255-3","volume":"8","author":"MG Stovell","year":"2018","unstructured":"Stovell MG, Mada MO, Helmy A, Carpenter TA, Thelin EP, Yan JL et al (2018) The effect of succinate on brain NADH\/NAD(+) redox state and high energy phosphate metabolism in acute traumatic brain injury. Sci Rep 8(1):11140","journal-title":"Sci Rep"},{"issue":"7","key":"4589_CR28","doi-asserted-by":"publisher","first-page":"2626","DOI":"10.1177\/0271678X16672665","volume":"37","author":"I Jalloh","year":"2017","unstructured":"Jalloh I, Helmy A, Howe DJ, Shannon RJ, Grice P, Mason A et al (2017) Focally perfused succinate potentiates brain metabolism in head injury patients. J Cerebral Blood Flow Metabol 37(7):2626\u20132638","journal-title":"J Cerebral Blood Flow Metabol"},{"issue":"1","key":"4589_CR29","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1038\/s41598-017-01149-w","volume":"7","author":"S Giorgi-Coll","year":"2017","unstructured":"Giorgi-Coll S, Amaral AI, Hutchinson PJA, Kotter MR, Carpenter KLH (2017) Succinate supplementation improves metabolic performance of mixed glial cell cultures with mitochondrial dysfunction. Sci Rep 7(1):1003","journal-title":"Sci Rep"},{"issue":"5","key":"4589_CR30","doi-asserted-by":"publisher","first-page":"427","DOI":"10.2169\/internalmedicine.43.427","volume":"43","author":"H Oguro","year":"2004","unstructured":"Oguro H, Iijima K, Takahashi K, Nagai A, Bokura H, Yamaguchi S et al (2004) Successful treatment with succinate in a patient with MELAS. Internal Med (Tokyo, Japan) 43(5):427\u2013431","journal-title":"Internal Med (Tokyo, Japan)"},{"key":"4589_CR31","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.3389\/fneur.2019.01315","volume":"10","author":"BD Paul","year":"2019","unstructured":"Paul BD, Snyder SH (2019) Therapeutic applications of cysteamine and cystamine in neurodegenerative and neuropsychiatric diseases. Front Neurol 10:1315","journal-title":"Front Neurol"},{"key":"4589_CR32","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.brainres.2010.03.079","volume":"1335","author":"L Sun","year":"2010","unstructured":"Sun L, Xu S, Zhou M, Wang C, Wu Y, Chan P (2010) Effects of cysteamine on MPTP-induced dopaminergic neurodegeneration in mice. Brain Res 1335:74\u201382","journal-title":"Brain Res"},{"issue":"2","key":"4589_CR33","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.pnpbp.2010.11.023","volume":"35","author":"C Gibrat","year":"2011","unstructured":"Gibrat C, Cicchetti F (2011) Potential of cystamine and cysteamine in the treatment of neurodegenerative diseases. Prog Neuropsychopharmacol Biol Psychiatry 35(2):380\u2013389","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"2","key":"4589_CR34","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1071\/BI9850139","volume":"38","author":"RJ Mead","year":"1985","unstructured":"Mead RJ, Moulden DL, Twigg LE (1985) Significance of sulfhydryl compounds in the manifestation of fluoroacetate toxicity to the rat, brush-tailed possum, woylie and western grey kangaroo. Aust J Biol Sci 38(2):139\u2013149","journal-title":"Aust J Biol Sci"},{"issue":"1","key":"4589_CR35","first-page":"62","volume":"95","author":"JO Hutchens","year":"1949","unstructured":"Hutchens JO, Wagner H et al (1949) The effect of ethanol and various metabolites on fluoroacetate poisoning. J Pharmacol Exp Ther 95(1):62\u201370","journal-title":"J Pharmacol Exp Ther"},{"issue":"3","key":"4589_CR36","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1080\/109158101317097728","volume":"20","author":"MA Miller","year":"2001","unstructured":"Miller MA (2001) Gender-based differences in the toxicity of pharmaceuticals\u2014the Food and Drug Administration\u2019s perspective. Int J Toxicol 20(3):149\u2013152","journal-title":"Int J Toxicol"},{"issue":"3","key":"4589_CR37","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/0278-6915(94)00136-C","volume":"33","author":"RL Lipnick","year":"1995","unstructured":"Lipnick RL, Cotruvo JA, Hill RN, Bruce RD, Stitzel KA, Walker AP et al (1995) Comparison of the up-and-down, conventional LD50, and fixed-dose acute toxicity procedures. Food Chem Toxicol 33(3):223\u2013231","journal-title":"Food Chem Toxicol"},{"issue":"4","key":"4589_CR38","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1007\/s40572-017-0171-y","volume":"4","author":"N Comfort","year":"2017","unstructured":"Comfort N, Re DB (2017) Sex-specific neurotoxic effects of organophosphate pesticides across the life course. Curr Environ Health Rep 4(4):392\u2013404","journal-title":"Curr Environ Health Rep"},{"key":"4589_CR39","doi-asserted-by":"publisher","first-page":"196","DOI":"10.3389\/fgene.2018.00196","volume":"9","author":"C Torres-Rojas","year":"2018","unstructured":"Torres-Rojas C, Jones BC (2018) Sex differences in neurotoxicogenetics. Front Genet 9:196","journal-title":"Front Genet"},{"issue":"3","key":"4589_CR40","doi-asserted-by":"publisher","first-page":"143","DOI":"10.2165\/00003088-200948030-00001","volume":"48","author":"OP Soldin","year":"2009","unstructured":"Soldin OP, Mattison DR (2009) Sex differences in pharmacokinetics and pharmacodynamics. Clin Pharmacokinet 48(3):143\u2013157","journal-title":"Clin Pharmacokinet"},{"key":"4589_CR41","doi-asserted-by":"publisher","first-page":"113804","DOI":"10.1016\/j.addr.2021.05.014","volume":"175","author":"CM Madla","year":"2021","unstructured":"Madla CM, Gavins FKH, Merchant HA, Orlu M, Murdan S, Basit AW (2021) Let\u2019s talk about sex: Differences in drug therapy in males and females. Adv Drug Deliv Rev 175:113804","journal-title":"Adv Drug Deliv Rev"},{"key":"4589_CR42","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1210\/endocr\/bqac058","volume":"163","author":"BC \u00d6zdemir","year":"2022","unstructured":"\u00d6zdemir BC, Gerard CL, Espinosa da SC (2022) Sex and gender differences in anticancer treatment toxicity: a call for revisiting drug dosing in oncology. Endocrinology 163:6","journal-title":"Endocrinology"},{"key":"4589_CR43","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3390\/jpm12060907","volume":"12","author":"M Romanescu","year":"2022","unstructured":"Romanescu M, Buda V, Lombrea A, Andor M, Ledeti I, Suciu M et al (2022) Sex-related differences in pharmacological response to CNS drugs: a narrative review. J Personal Med 12:6","journal-title":"J Personal Med"},{"issue":"4","key":"4589_CR44","doi-asserted-by":"publisher","first-page":"335","DOI":"10.4062\/biomolther.2018.103","volume":"26","author":"HI Kim","year":"2018","unstructured":"Kim HI, Lim H, Moon A (2018) Sex differences in cancer: epidemiology. Genet Therapy Biomol Ther (Seoul) 26(4):335\u2013342","journal-title":"Genet Therapy Biomol Ther (Seoul)"},{"issue":"1\u20132","key":"4589_CR45","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s10863-014-9583-7","volume":"47","author":"TG Demarest","year":"2015","unstructured":"Demarest TG, McCarthy MM (2015) Sex differences in mitochondrial (dys)function: implications for neuroprotection. J Bioenerg Biomembr 47(1\u20132):173\u2013188","journal-title":"J Bioenerg Biomembr"},{"issue":"1","key":"4589_CR46","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s13293-018-0193-7","volume":"9","author":"C Silaidos","year":"2018","unstructured":"Silaidos C, Pilatus U, Grewal R, Matura S, Lienerth B, Pantel J et al (2018) Sex-associated differences in mitochondrial function in human peripheral blood mononuclear cells (PBMCs) and brain. Biol Sex Differ 9(1):34","journal-title":"Biol Sex Differ"},{"issue":"5","key":"4589_CR47","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1111\/jnc.13590","volume":"137","author":"TG Demarest","year":"2016","unstructured":"Demarest TG, Schuh RA, Waddell J, McKenna MC, Fiskum G (2016) Sex-dependent mitochondrial respiratory impairment and oxidative stress in a rat model of neonatal hypoxic-ischemic encephalopathy. J Neurochem 137(5):714\u2013729","journal-title":"J Neurochem"},{"key":"4589_CR48","doi-asserted-by":"publisher","first-page":"753946","DOI":"10.3389\/fnmol.2021.753946","volume":"14","author":"OJ Kalimon","year":"2021","unstructured":"Kalimon OJ, Sullivan PG (2021) Sex differences in mitochondrial function following a controlled cortical impact traumatic brain injury in rodents. Front Mol Neurosci 14:753946","journal-title":"Front Mol Neurosci"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-022-04589-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-022-04589-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-022-04589-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T15:02:58Z","timestamp":1683385378000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-022-04589-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,25]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["4589"],"URL":"https:\/\/doi.org\/10.1007\/s11010-022-04589-9","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,25]]},"assertion":[{"value":"11 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"S.P., M.K., J.K.E., E.E. and M.J.H have, or have had, salary from and\/or equity interest in Abliva AB. S.P., J.K.E., E.E. and M.J.H have filed patent applications for the use of succinate prodrugs for treatment of lactic acidosis or drug-induced side-effects due to complex I-related impairment of mitochondrial oxidative phosphorylation (WO\/2015\/155238). S.P., M.K., J.K.E., E.E. and M.J.H additionally have filed patent applications for the use of protected carboxylic acid-based metabolites for treatment of mitochondrial disorders (WO\/2017\/060400, WO\/2017\/060418, WO\/2017\/060422).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All procedures were approved by the Institutional Animal Care and Use Committee at the Children\u2019s Hospital of Philadelphia and performed in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}