{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T07:15:34Z","timestamp":1775978134473,"version":"3.50.1"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100020328","name":"University of Petra","doi-asserted-by":"crossref","award":["11\/4\/2019"],"award-info":[{"award-number":["11\/4\/2019"]}],"id":[{"id":"10.13039\/100020328","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1007\/s11010-022-04648-1","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T08:02:50Z","timestamp":1672387370000},"page":"1949-1960","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Transcriptional profiling of drug-induced liver injury biomarkers: association of hepatic Srebf1\/Ppar\u03b1 signaling and crosstalk of thrombin, alcohol dehydrogenase, MDR and DNA damage regulators"],"prefix":"10.1007","volume":"478","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8922-7815","authenticated-orcid":false,"given":"Bayan Y.","family":"Ghanim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9072-4173","authenticated-orcid":false,"given":"Qasem","family":"Abdallah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anas","family":"Khaleel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9628-6036","authenticated-orcid":false,"given":"Nidal A.","family":"Qinna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,12,30]]},"reference":[{"key":"4648_CR1","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1002\/jat.3740","volume":"7","author":"NA Qinna","year":"2019","unstructured":"Qinna NA, Ghanim BY (2019) Chemical induction of hepatic apoptosis in rodents. J Appl Toxicol 7:178\u2013190. https:\/\/doi.org\/10.1002\/jat.3740","journal-title":"J Appl Toxicol"},{"key":"4648_CR2","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1002\/hep.21831","volume":"46","author":"JM Maher","year":"2007","unstructured":"Maher JM, Dieter MZ, Aleksunes LM, Slitt AL, Guo G, Tanaka Y, Scheffer GL, Chan JY, Manautou JE, Chen Y, Dalton TP, Yamamoto M, Klaassen CD (2007) Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway. Hepatology 46:1597\u20131610. https:\/\/doi.org\/10.1002\/hep.21831","journal-title":"Hepatology"},{"key":"4648_CR3","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/jid.2014.371","volume":"1","author":"LM Aleksunes","year":"2008","unstructured":"Aleksunes LM, Slitt AL, Maher JM, Augustine LM, Manautou M (2008) Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2. Toxicol Appl Pharmacol 1:74\u201383. https:\/\/doi.org\/10.1038\/jid.2014.371","journal-title":"Toxicol Appl Pharmacol"},{"key":"4648_CR4","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1080\/01926230701320337","volume":"35","author":"S Elmore","year":"2007","unstructured":"Elmore S (2007) Apoptosis: a review of programmed cell death. Toxicol Pathol 35:495\u2013516. https:\/\/doi.org\/10.1080\/01926230701320337","journal-title":"Toxicol Pathol"},{"key":"4648_CR5","doi-asserted-by":"publisher","first-page":"5718","DOI":"10.1093\/nar\/gkq212","volume":"38","author":"D Malhotra","year":"2010","unstructured":"Malhotra D, Portales-Casamar E, Singh A, Srivastava S, Arenillas D, Happel C, Shyr C, Wakabayashi N, Kensler TW, Wasserman WW, Biswal S, Singh A, Kensler TW, Arenillas D, Wakabayashi N, Srivastava S, Wasserman WW, Biswal S, Malhotra D, Shyr C, Portales-Casamar E (2010) Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through chip-seq profiling and network analysis. Nucleic Acids Res 38:5718\u20135734. https:\/\/doi.org\/10.1093\/nar\/gkq212","journal-title":"Nucleic Acids Res"},{"key":"4648_CR6","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.molcel.2017.09.009","volume":"68","author":"D Chen","year":"2017","unstructured":"Chen D, Tavana O, Chu B, Erber L, Chen Y, Baer R, Gu W (2017) NRF2 is a major target of ARF in p53-independent tumor suppression. Mol Cell 68:224-232.e4. https:\/\/doi.org\/10.1016\/j.molcel.2017.09.009","journal-title":"Mol Cell"},{"key":"4648_CR7","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nature14344","volume":"520","author":"L Jiang","year":"2015","unstructured":"Jiang L, Kon N, Li T, Wang SJ, Su T, Hibshoosh H, Baer R, Gu W (2015) Ferroptosis as a p53-mediated activity during tumour suppression. Nature 520:57\u201362. https:\/\/doi.org\/10.1038\/nature14344","journal-title":"Nature"},{"key":"4648_CR8","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/cdd.2011.164","volume":"19","author":"N Vanlangenakker","year":"2012","unstructured":"Vanlangenakker N, Vanden Berghe T, Vandenabeele P, Vanden Berghe T, Vandenabeele P (2012) Many stimuli pull the necrotic trigger, an overview. Cell Death Differ 19:75\u201386. https:\/\/doi.org\/10.1038\/cdd.2011.164","journal-title":"Cell Death Differ"},{"key":"4648_CR9","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/j.1582-4934.2005.tb00337.x","volume":"9","author":"G Song","year":"2005","unstructured":"Song G, Ouyang G, Bao S (2005) The activation of Akt\/PKB signaling pathway and cell survival. J Cell Mol Med 9:59\u201371. https:\/\/doi.org\/10.1111\/j.1582-4934.2005.tb00337.x","journal-title":"J Cell Mol Med"},{"key":"4648_CR10","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1093\/toxsci\/kfr183","volume":"123","author":"KC Wu","year":"2011","unstructured":"Wu KC, Cui JY, Klaassen CD (2011) Beneficial role of Nrf2 in regulating NADPH generation and consumption. Toxicol Sci 123:590\u2013600. https:\/\/doi.org\/10.1093\/toxsci\/kfr183","journal-title":"Toxicol Sci"},{"key":"4648_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0172463","volume":"12","author":"YE Cho","year":"2017","unstructured":"Cho YE, Im EJ, Moon PG, Mezey E, Song BJ, Baek MC (2017) Increased liver-specific proteins in circulating extracellular vesicles as potential biomarkers for drug- and alcohol-induced liver injury. PLoS ONE 12:1\u201323. https:\/\/doi.org\/10.1371\/journal.pone.0172463","journal-title":"PLoS ONE"},{"key":"4648_CR12","doi-asserted-by":"publisher","first-page":"112","DOI":"10.4062\/biomolther.2016.076","volume":"25","author":"M Kim","year":"2017","unstructured":"Kim M, Yun JW, Shin K, Cho Y, Yang M, Nam KT, Lim KM (2017) Expression levels of GABA-A receptor subunit alpha 3, Gabra3 and lipoprotein lipase, Lpl are associated with the susceptibility to acetaminophen-induced hepatotoxicity. Biomol Therapeut 25:112\u2013121. https:\/\/doi.org\/10.4062\/biomolther.2016.076","journal-title":"Biomol Therapeut"},{"key":"4648_CR13","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1172\/JCI119248","volume":"99","author":"H Shimano","year":"1997","unstructured":"Shimano H, Horton JD, Shimomura I, Hammer RE, Brown MS, Goldstein JL (1997) Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. J Clin Investig 99:846\u2013854. https:\/\/doi.org\/10.1172\/JCI119248","journal-title":"J Clin Investig"},{"key":"4648_CR14","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1172\/jci15593","volume":"109","author":"JD Horton","year":"2002","unstructured":"Horton JD, Goldstein JL, Brown MS (2002) SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Investig 109:1125\u20131131. https:\/\/doi.org\/10.1172\/jci15593","journal-title":"J Clin Investig"},{"key":"4648_CR15","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/S0140-6736(09)61040-0","volume":"374","author":"B Charbonnel","year":"2009","unstructured":"Charbonnel B (2009) PPAR-\u03b1 and PPAR-\u03b3 agonists for type 2 diabetes. Lancet 374:96\u201398. https:\/\/doi.org\/10.1016\/S0140-6736(09)61040-0","journal-title":"Lancet"},{"key":"4648_CR16","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/nrendo.2016.135","volume":"13","author":"B Gross","year":"2017","unstructured":"Gross B, Pawlak M, Lefebvre P, Staels B (2017) PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD. Nat Rev Endocrinol 13:36\u201349. https:\/\/doi.org\/10.1038\/nrendo.2016.135","journal-title":"Nat Rev Endocrinol"},{"key":"4648_CR17","doi-asserted-by":"publisher","first-page":"2641","DOI":"10.1242\/jcs.01284","volume":"117","author":"HM Beere","year":"2004","unstructured":"Beere HM (2004) \u201cThe stress of dying\u201d: the role of heat shock proteins in the regulation of apoptosis. J Cell Sci 117:2641\u20132651. https:\/\/doi.org\/10.1242\/jcs.01284","journal-title":"J Cell Sci"},{"key":"4648_CR18","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1093\/toxsci\/kfz222","volume":"173","author":"JH Vazquez","year":"2020","unstructured":"Vazquez JH, Clemens MM, Allard FD, Yee EU, Kennon-McGill S, Mackintosh SG, Jaeschke H, Hambuchen MD, McGill MR (2020) Identification of serum biomarkers to distinguish hazardous and benign aminotransferase elevations. Toxicol Sci 173:244\u2013254. https:\/\/doi.org\/10.1093\/toxsci\/kfz222","journal-title":"Toxicol Sci"},{"key":"4648_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2014.03.023.Coagulation","author":"AK Kopec","year":"2014","unstructured":"Kopec AK, Luyendyk JP (2014) Coagulation in liver toxicity and disease: role of hepatocyte tissue factor. Thromb Res. https:\/\/doi.org\/10.1016\/j.thromres.2014.03.023.Coagulation","journal-title":"Thromb Res"},{"key":"4648_CR20","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.taap.2012.08.015","volume":"264","author":"MR McGill","year":"2012","unstructured":"McGill MR, Williams CD, Xie Y, Ramachandran A, Jaeschke H (2012) Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity. Toxicol Appl Pharmacol 264:387\u2013394. https:\/\/doi.org\/10.1016\/j.taap.2012.08.015","journal-title":"Toxicol Appl Pharmacol"},{"issue":"9","key":"4648_CR21","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1101\/gr.090241.108","volume":"19","author":"AH Harrill","year":"2009","unstructured":"Harrill AH, Watkins PB, Su S, Ross PK, Harbourt DE, Stylianou IM, Boorman GA, Russo MW, Sackler RS, Harris SC, Smith PC, Tennant R, Bogue M, Paigen K, Harris C, Contractor T, Wiltshire T, Rusyn I, Threadgill DW (2009) Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans. Genome Res 19(9):1507\u20131515. https:\/\/doi.org\/10.1101\/gr.090241.108","journal-title":"Genome Res"},{"key":"4648_CR22","doi-asserted-by":"publisher","first-page":"131","DOI":"10.3390\/molecules24010131","volume":"24","author":"HC Zhou","year":"2019","unstructured":"Zhou HC, Wang H, Shi K, Li JM, Zong Y, Du R (2019) Hepatoprotective effect of baicalein against acetaminophen-induced acute liver injury in mice. Molecules 24:131. https:\/\/doi.org\/10.3390\/molecules24010131","journal-title":"Molecules"},{"key":"4648_CR23","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1002\/hep.26134","volume":"57","author":"BV Martin-Murphy","year":"2013","unstructured":"Martin-Murphy BV, Kominsky DJ, Orlicky DJ, Donohue TM, Ju C (2013) Increased susceptibility of natural killer T-cell-deficient mice to acetaminophen-induced liver injury. Hepatology 57:1575\u20131584. https:\/\/doi.org\/10.1002\/hep.26134","journal-title":"Hepatology"},{"key":"4648_CR24","doi-asserted-by":"publisher","DOI":"10.1177\/09603271211027947","author":"B Ghanim","year":"2021","unstructured":"Ghanim B, Ahmad M, Abdallah Q, Qatouseh L, Qinna N (2021) Modulation of NRF2\/ARE pathway- and cell death-related genes during drug-induced liver injury. Hum Exp Toxicol. https:\/\/doi.org\/10.1177\/09603271211027947","journal-title":"Hum Exp Toxicol"},{"key":"4648_CR25","doi-asserted-by":"crossref","unstructured":"Abu-Ajamieh RN, Ghanim BY, Gammoh OS, Qinna NA (2020) Hepatocyte apoptosis induction by acetaminophen through modulation of caspase\/Bax pathway in mice. Int J Pharmacy Pharmaceut Sci 12","DOI":"10.22159\/ijpps.2020v12i11.39141"},{"key":"4648_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep25533","volume":"6","author":"S Parekh","year":"2016","unstructured":"Parekh S, Ziegenhain C, Vieth B, Enard W, Hellmann I (2016) The impact of amplification on differential expression analyses by RNA-seq. Sci Rep 6:1\u201311. https:\/\/doi.org\/10.1038\/srep25533","journal-title":"Sci Rep"},{"key":"4648_CR27","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.rvsc.2017.09.025","volume":"114","author":"DA Sandercock","year":"2017","unstructured":"Sandercock DA, Coe JE, Di Giminiani P, Edwards SA (2017) Determination of stable reference genes for RT-qPCR expression data in mechanistic pain studies on pig dorsal root ganglia and spinal cord. Res Vet Sci 114:493\u2013501. https:\/\/doi.org\/10.1016\/j.rvsc.2017.09.025","journal-title":"Res Vet Sci"},{"key":"4648_CR28","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/1471-2105-4-26","volume":"4","author":"X Peng","year":"2003","unstructured":"Peng X, Wood CL, Blalock EM, Chen KC, Landfield PW, Stromberg AJ (2003) Statistical implications of pooling RNA samples for microarray experiments. BMC Bioinformatics 4:26. https:\/\/doi.org\/10.1186\/1471-2105-4-26","journal-title":"BMC Bioinformatics"},{"key":"4648_CR29","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1186\/s12864-020-6721-y","volume":"21","author":"AT Assefa","year":"2020","unstructured":"Assefa AT, Vandesompele J, Thas O (2020) On the utility of RNA sample pooling to optimize cost and statistical power in RNA sequencing experiments. BMC Genom 21:312. https:\/\/doi.org\/10.1186\/s12864-020-6721-y","journal-title":"BMC Genom"},{"key":"4648_CR30","doi-asserted-by":"publisher","first-page":"9235","DOI":"10.2147\/CMAR.S266473","volume":"12","author":"Y Peng","year":"2020","unstructured":"Peng Y, Zhang HW, Cao WH, Mao Y, Cheng RC (2020) Exploration of the potential biomarkers of papillary thyroid cancer (Ptc) based on rt2 profiler pcr arrays and bioinformatics analysis. Cancer Manag Res 12:9235\u20139246. https:\/\/doi.org\/10.2147\/CMAR.S266473","journal-title":"Cancer Manag Res"},{"key":"4648_CR31","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1186\/s13041-019-0526-4","volume":"12","author":"H Wang","year":"2019","unstructured":"Wang H, Rangaswamy S, Kodavati M, Mitra J, Guo W, Guerrero EN, Van Den Bosch L, Hegde ML (2019) RT2 PCR array screening reveals distinct perturbations in DNA damage response signaling in FUS-associated motor neuron disease. Mol Brain 12:103. https:\/\/doi.org\/10.1186\/s13041-019-0526-4","journal-title":"Mol Brain"},{"key":"4648_CR32","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3390\/medicines6030079","volume":"6","author":"B Hedgpeth","year":"2019","unstructured":"Hedgpeth B, Missall R, Bambaci A, Smolen M, Yavuz S, Cottrell J, Chu T, Chang SL (2019) A review of bioinformatics tools to understand acetaminophen-alcohol interaction. Medicines 6:79. https:\/\/doi.org\/10.3390\/medicines6030079","journal-title":"Medicines"},{"key":"4648_CR33","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1016\/j.bbadis.2018.08.037","volume":"2019","author":"MR McGill","year":"1865","unstructured":"McGill MR, Jaeschke H (1865) Animal models of drug-induced liver injury. Biochim Biophys Acta Mol Basis Dis 2019:1031\u20131039. https:\/\/doi.org\/10.1016\/j.bbadis.2018.08.037","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"4648_CR34","doi-asserted-by":"publisher","DOI":"10.3945\/jn.114.193573.1211","author":"J Zhang","year":"2014","unstructured":"Zhang J, Xu L, Zhang L, Ying Z, Su W, Wang T (2014) Curcumin attenuates D-galactosamine\/lipopolysaccharide\u2014induced liver injury and mitochondrial dysfunction in mice 1\u20133. J Nutr. https:\/\/doi.org\/10.3945\/jn.114.193573.1211","journal-title":"J Nutr"},{"key":"4648_CR35","doi-asserted-by":"publisher","first-page":"181","DOI":"10.3390\/medicina55050181","volume":"55","author":"AM Abdulrazzaq","year":"2019","unstructured":"Abdulrazzaq AM, Badr M, Gammoh O, Abu-Khalil AA, Ghanim BY, Alhussainy TM, Qinna NA (2019) Hepatoprotective actions of ascorbic acid, alpha lipoic acid and silymarin or their combination against acetaminophen-induced hepatotoxicity in rats. Medicina (B Aires) 55:181. https:\/\/doi.org\/10.3390\/medicina55050181","journal-title":"Medicina (B Aires)"},{"key":"4648_CR36","unstructured":"Arora P, Jadaun SS, Das P, Shalimar, Data SK (2019) Unusually low serum alkaline phosphatase activity in a patient with acute on chronic liver failure and hemolysis. Electron J Int Feder Clin Chem Laborat Med 30:99\u2013105"},{"key":"4648_CR37","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.mri.2011.09.023","volume":"30","author":"AT Brown","year":"2012","unstructured":"Brown AT, Ou X, James LP, Jambhekar K, Pandey T, McCullough S, Chaudhuri S, Borrelli MJ (2012) Correlation of MRI findings to histology of acetaminophen toxicity in the mouse. Magn Reson Imaging 30:283\u2013289. https:\/\/doi.org\/10.1016\/j.mri.2011.09.023","journal-title":"Magn Reson Imaging"},{"key":"4648_CR38","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/cld.653","volume":"10","author":"M Krishna","year":"2017","unstructured":"Krishna M (2017) Patterns of necrosis in liver disease. Clin Liver Dis 10:53\u201356. https:\/\/doi.org\/10.1002\/cld.653","journal-title":"Clin Liver Dis"},{"key":"4648_CR39","doi-asserted-by":"publisher","unstructured":"P. Gill, S. Bhattacharyya, S. McCullough, L. Letzig, P.J. Mishra, C. Luo, H. Dweep, L. James, MicroRNA regulation of CYP 1A2, CYP3A4 and CYP2E1 expression in acetaminophen toxicity, Scientific Reports. 7 (2017). https:\/\/doi.org\/10.1038\/s41598-017-11811-y","DOI":"10.1038\/s41598-017-11811-y"},{"key":"4648_CR40","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1055\/s-0038-1667299","volume":"38","author":"MC Reichert","year":"2018","unstructured":"Reichert MC, Lammert F (2018) ABCB4 gene aberrations in human liver disease: an evolving spectrum. Semin Liver Dis 38:299\u2013307. https:\/\/doi.org\/10.1055\/s-0038-1667299","journal-title":"Semin Liver Dis"},{"key":"4648_CR41","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1007\/s11626-013-9646-9","volume":"49","author":"X Shan","year":"2013","unstructured":"Shan X, Miao Y, Fan R, Song C, Wu G, Wan Z, Zhu J, Sun G, Zha W, Mu X, Zhou G, Chen Y (2013) Suppression of Grb2 expression improved hepatic steatosis, oxidative stress, and apoptosis induced by palmitic acid in vitro partly through insulin signaling alteration. In Vitro Cell Dev Biol Anim 49:576\u2013582. https:\/\/doi.org\/10.1007\/s11626-013-9646-9","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"4648_CR42","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1002\/hep.25645","volume":"56","author":"AD Patterson","year":"2012","unstructured":"Patterson AD, Shah YM, Matsubara T, Krausz KW, Gonzalez FJ (2012) Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity. Hepatology 56:281\u2013290. https:\/\/doi.org\/10.1002\/hep.25645","journal-title":"Hepatology"},{"key":"4648_CR43","doi-asserted-by":"publisher","first-page":"705","DOI":"10.3389\/fphar.2017.00705","volume":"8","author":"P Rivera","year":"2017","unstructured":"Rivera P, Pastor A, Arrabal S, Decara J, Vargas A, S\u00e1nchez-Mar\u00edn L, Pav\u00f3n FJ, Serrano A, Bautista D, Boronat A, de la Torre R, Baixeras E, Lucena MI, de Fonseca FR, Su\u00e1rez J (2017) Acetaminophen-induced liver injury alters the Acyl ethanolamine-based anti-inflammatory signaling system in liver. Front Pharmacol 8:705. https:\/\/doi.org\/10.3389\/fphar.2017.00705","journal-title":"Front Pharmacol"},{"key":"4648_CR44","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1093\/toxsci\/57.2.187","volume":"57","author":"HM Mehendale","year":"2000","unstructured":"Mehendale HM (2000) PPAR-\u03b1: a key to the mechanism of hepatoprotection by clofibrate. Toxicol Sci 57:187\u2013190. https:\/\/doi.org\/10.1093\/toxsci\/57.2.187","journal-title":"Toxicol Sci"},{"key":"4648_CR45","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfaa032","author":"AC Donepudi","year":"2020","unstructured":"Donepudi AC, Smith GJ, Aladelokun O, Lee Y, Toro SJ, Pfohl M, Slitt AL, Wang L, Lee J-Y, Schuetz JD, Manautou JE (2020) Lack of multidrug-resistance associated protein 4 prolongs partial hepatectomy-induced hepatic steatosis. Toxicol Sci. https:\/\/doi.org\/10.1093\/toxsci\/kfaa032","journal-title":"Toxicol Sci"},{"key":"4648_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/cpr.12445","volume":"51","author":"P Viswanathan","year":"2018","unstructured":"Viswanathan P, Sharma Y, Gupta P, Gupta S (2018) Replicative stress and alterations in cell cycle checkpoint controls following acetaminophen hepatotoxicity restrict liver regeneration. Cell Prolif 51:1\u201314. https:\/\/doi.org\/10.1111\/cpr.12445","journal-title":"Cell Prolif"},{"key":"4648_CR47","doi-asserted-by":"publisher","first-page":"6762","DOI":"10.1038\/onc.2017.254","volume":"36","author":"LE Giono","year":"2017","unstructured":"Giono LE, Resnick-Silverman L, Carvajal LA, St Clair S, Manfredi JJ (2017) Mdm2 promotes Cdc25C protein degradation and delays cell cycle progression through the G2\/M phase. Oncogene 36:6762\u20136773. https:\/\/doi.org\/10.1038\/onc.2017.254","journal-title":"Oncogene"},{"key":"4648_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41419-018-0507-z","volume":"9","author":"J Sun","year":"2018","unstructured":"Sun J, Wen Y, Zhou Y, Jiang Y, Chen Y, Zhang H, Guan L, Yao X, Huang M, Bi H (2018) P53 attenuates acetaminophen-induced hepatotoxicity by regulating drug-metabolizing enzymes and transporter expression article. Cell Death Dis 9:1\u201312. https:\/\/doi.org\/10.1038\/s41419-018-0507-z","journal-title":"Cell Death Dis"},{"key":"4648_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4137\/GRSB.S25388","volume":"9","author":"BD Stamper","year":"2015","unstructured":"Stamper BD, Garcia ML, Nguyen DQ, Beyer RP, Bammler TK, Farin FM, Kavanagh TJ, Nelson SD (2015) P53 contributes to differentiating gene expression following exposure to acetaminophen and its less hepatotoxic regioisomer both in vitro and in vivo. Gene Regul Syst Biol 9:1\u201314. https:\/\/doi.org\/10.4137\/GRSB.S25388","journal-title":"Gene Regul Syst Biol"},{"key":"4648_CR50","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1002\/jat.3226","volume":"36","author":"C Wang","year":"2016","unstructured":"Wang C, Yang J, Lu D, Fan Y, Zhao M, Li Z (2016) Oxidative stress-related DNA damage and homologous recombination repairing induced by N,N-dimethylformamide. J Appl Toxicol 36:936\u2013945. https:\/\/doi.org\/10.1002\/jat.3226","journal-title":"J Appl Toxicol"},{"key":"4648_CR51","doi-asserted-by":"publisher","first-page":"115","DOI":"10.3727\/105221618X15205260749346","volume":"18","author":"P Borude","year":"2018","unstructured":"Borude P, Bhushan B, Apte U (2018) DNA damage response regulates initiation of liver regeneration following acetaminophen overdose. Gene Expr 18:115\u2013123. https:\/\/doi.org\/10.3727\/105221618X15205260749346","journal-title":"Gene Expr"},{"key":"4648_CR52","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1111\/jgh.12425","volume":"29","author":"L Li","year":"2014","unstructured":"Li L, Zhang T, Zhou L, Xing G, Chen Y, Xin Y (2014) Schisandrin B attenuates acetaminophen-induced hepatic injury through heat-shock protein 27 and 70 in mice. J Gastroenterol Hepatol (Austr) 29:640\u2013647. https:\/\/doi.org\/10.1111\/jgh.12425","journal-title":"J Gastroenterol Hepatol (Austr)"},{"key":"4648_CR53","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/S0006-291X(03)00572-2","volume":"304","author":"Y Masubuchi","year":"2003","unstructured":"Masubuchi Y, Bourdi M, Reilly TP, Graf MLM, George JW, Pohl LR (2003) Role of interleukin-6 in hepatic heat shock protein expression and protection against acetaminophen-induced liver disease. Biochem Biophys Res Commun 304:207\u2013212. https:\/\/doi.org\/10.1016\/S0006-291X(03)00572-2","journal-title":"Biochem Biophys Res Commun"},{"key":"4648_CR54","doi-asserted-by":"publisher","first-page":"2551","DOI":"10.1016\/j.lfs.2003.10.011","volume":"74","author":"I Sumioka","year":"2004","unstructured":"Sumioka I, Matsura T, Kai M, Yamada K (2004) Potential roles of hepatic heat shock protein 25 and 70i in protection of mice against acetaminophen-induced liver injury. Life Sci 74:2551\u20132561. https:\/\/doi.org\/10.1016\/j.lfs.2003.10.011","journal-title":"Life Sci"},{"key":"4648_CR55","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1016\/j.jhep.2018.01.003","volume":"68","author":"K Levada","year":"2018","unstructured":"Levada K, Guldiken N, Zhang X, Vella G, Mo FR, James LP, Haybaeck J, Kessler SM, Kiemer AK, Ott T, Hartmann D, H\u00fcser N, Ziol M, Trautwein C, Strnad P (2018) Hsp72 protects against liver injury via attenuation of hepatocellular death, oxidative stress, and JNK signaling. J Hepatol 68:996\u20131005. https:\/\/doi.org\/10.1016\/j.jhep.2018.01.003","journal-title":"J Hepatol"},{"key":"4648_CR56","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1002\/hep.28251","volume":"63","author":"X Sun","year":"2016","unstructured":"Sun X, Ou Z, Chen R, Niu X, Chen D, Kang R, Tang D (2016) Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells. Hepatology 63:173\u2013184. https:\/\/doi.org\/10.1002\/hep.28251","journal-title":"Hepatology"},{"key":"4648_CR57","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-13-8","author":"S Huss","year":"2013","unstructured":"Huss S, Stellmacher C, Goltz D, Khlistunova I, Adam AC, Trebicka J, Kirfel J, B\u00fcttner R, Weiskirchen R (2013) Deficiency in four and one half LIM domain protein 2 (FHL2) aggravates liver fibrosis in mice. BMC Gastroenterol. https:\/\/doi.org\/10.1186\/1471-230X-13-8","journal-title":"BMC Gastroenterol"},{"key":"4648_CR58","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18071484","author":"W-R Xia","year":"2017","unstructured":"Xia W-R, Fu W, Wang Q, Zhu X, Xing W-W, Wang M, Xu D-Q, Xu D-G (2017) Autophagy induced FHL2 upregulation promotes IL-6 production by activating the NF-\u03baB pathway in mouse aortic endothelial cells after exposure to PM25. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms18071484","journal-title":"Int J Mol Sci"},{"key":"4648_CR59","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1002\/hep.26968","volume":"59","author":"J Bi","year":"2014","unstructured":"Bi J, Zhang Q, Liang D, Xiong L, Wei H, Sun R, Tian Z (2014) T-cell Ig and ITIM domain regulates natural killer cell activation in murine acute viral hepatitis. Hepatology 59:1715\u20131725. https:\/\/doi.org\/10.1002\/hep.26968","journal-title":"Hepatology"},{"key":"4648_CR60","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1182\/blood-2014-09-598656","volume":"126","author":"K Miyakawa","year":"2015","unstructured":"Miyakawa K, Joshi N, Sullivan BP, Albee R, Brandenberger C, Jaeschke H, McGill MR, Scott MA, Ganey PE, Luyendyk JP, Roth RA (2015) Platelets and protease-activated receptor-4 contribute to acetaminophen-induced liver injury in mice. Blood 126:1835\u20131845. https:\/\/doi.org\/10.1182\/blood-2014-09-598656","journal-title":"Blood"},{"key":"4648_CR61","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1002\/ajh.2830450313","volume":"45","author":"M Fischereder","year":"1994","unstructured":"Fischereder M, Jaffe JP (1994) Thrombocytopenia following acute acetaminophen. Am J Hematol 45:258\u2013259. https:\/\/doi.org\/10.1002\/ajh.2830450313","journal-title":"Am J Hematol"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-022-04648-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-022-04648-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-022-04648-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T08:06:17Z","timestamp":1689840377000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-022-04648-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,30]]},"references-count":61,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["4648"],"URL":"https:\/\/doi.org\/10.1007\/s11010-022-04648-1","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,30]]},"assertion":[{"value":"16 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}},{"value":"The study protocol was reviewed and approved by the Ethical Committee approval number 2A-2\u20132019, University of Petra (Amman, Jordan).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}