{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:09:55Z","timestamp":1788318595536,"version":"build-2803163510"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Research Development Program, Sir Ganga Ram Hospital, New Delhi, India","award":["4.9.35-010"],"award-info":[{"award-number":["4.9.35-010"]}]},{"name":"Research Development Program, Sir Ganga Ram Hospital, New Delhi, India","award":["4.9.35-010"],"award-info":[{"award-number":["4.9.35-010"]}]},{"name":"Research Development Program, Sir Ganga Ram Hospital, New Delhi, India","award":["4.9.35-010"],"award-info":[{"award-number":["4.9.35-010"]}]},{"name":"Research Development Program, Sir Ganga Ram Hospital, New Delhi, India","award":["4.9.35-010"],"award-info":[{"award-number":["4.9.35-010"]}]},{"name":"Research Development Program, Sir Ganga Ram Hospital, New Delhi, India","award":["4.9.35-010"],"award-info":[{"award-number":["4.9.35-010"]}]},{"name":"Research Development Program, Sir Ganga Ram Hospital, New Delhi, India","award":["4.9.35-010"],"award-info":[{"award-number":["4.9.35-010"]}]},{"name":"Research Development Program, Sir Ganga Ram Hospital, New Delhi, India","award":["4.9.35-010"],"award-info":[{"award-number":["4.9.35-010"]}]},{"name":"Research Development Program, Sir Ganga Ram Hospital, New Delhi, India","award":["4.9.35-010"],"award-info":[{"award-number":["4.9.35-010"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1007\/s11010-023-04679-2","type":"journal-article","created":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T18:23:49Z","timestamp":1679855029000},"page":"2497-2504","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Homocysteine and nutritional biomarkers in cognitive impairment"],"prefix":"10.1007","volume":"478","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0749-7999","authenticated-orcid":false,"given":"Bhargava","family":"Seema","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Sethi","family":"Prahlad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Batra","family":"Anuradha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choudhury","family":"Sangeeta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takkar","family":"Parul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manocha","family":"Anjali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kankra","family":"Mamta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Singla","family":"Parul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,13]]},"reference":[{"issue":"3","key":"4679_CR1","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1055\/s-0035-1555115","volume":"36","author":"DL Murman","year":"2015","unstructured":"Murman DL (2015) The impact of age on cognition. Semin Hear 36(3):111\u2013121","journal-title":"Semin Hear"},{"key":"4679_CR2","unstructured":"https:\/\/www.nature.com\/scitable\/content\/life-expectancy-around-the-world-has-increased-19786\/"},{"key":"4679_CR3","volume-title":"World population ageing, 1950\u20132050","author":"United Nations","year":"2002","unstructured":"United Nations (2002) World population ageing, 1950\u20132050. United Nations Department of Economic and Social Affairs, New York"},{"key":"4679_CR4","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1136\/pgmj.2005.036665","volume":"82","author":"R Peters","year":"2006","unstructured":"Peters R (2006) Ageing and the brain. Postgrad Med J 82:84\u201388","journal-title":"Postgrad Med J"},{"issue":"3","key":"4679_CR5","first-page":"392","volume":"138","author":"C Gopalan","year":"2013","unstructured":"Gopalan C (2013) The changing nutrition scenario. Indian J Med Res 138(3):392\u2013397","journal-title":"Indian J Med Res"},{"key":"4679_CR6","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1111\/j.1532-5415.2005.53153.x","volume":"53","author":"JH Schafer","year":"2005","unstructured":"Schafer JH, Glass TA, Bolla KI, Mintz M, Jedlicka AE, Schwartz BS (2005) Homocysteine and cognitive function in a population-based study of older adults. J Am Geriatr Soc 53:381\u2013388","journal-title":"J Am Geriatr Soc"},{"issue":"3","key":"4679_CR7","doi-asserted-by":"publisher","first-page":"222","DOI":"10.3164\/jcbn.11-72","volume":"50","author":"S Bhargava","year":"2012","unstructured":"Bhargava S, Ali A, Bhargava EK, Manocha A, Kankra M, Das S, Srivastava LM (2012) Lowering homocysteine and modifying nutritional status with folate and vitamin B12 in Indian patients of vascular disease. J Clin Biochem Nutr 50(3):222\u2013226","journal-title":"J Clin Biochem Nutr"},{"issue":"7135","key":"4679_CR8","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1136\/bmj.316.7135.894","volume":"316","author":"HLT Collaboration","year":"1998","unstructured":"Collaboration HLT (1998) Lowering blood homocysteine with folate based supplements: meta-analysis of randomised trials Homocysteine Lowering Trialists\u2019 Collaboration. BMJ 316(7135):894\u2013898","journal-title":"BMJ"},{"issue":"3","key":"4679_CR9","doi-asserted-by":"publisher","first-page":"H1206","DOI":"10.1152\/ajpheart.00376.2005","volume":"290","author":"D Lominadze","year":"2006","unstructured":"Lominadze D, Roberts AM, Tyagi N, Moshal KS, Tyagi SC (2006) Homocysteine causes cerebrovascular leakage in mice. Am J Physiol Heart Circ Physiol 290(3):H1206. https:\/\/doi.org\/10.1152\/ajpheart.00376.2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"4679_CR10","first-page":"1008","volume":"5","author":"AH Hainsworth","year":"1862","unstructured":"Hainsworth AH, Yeo NE, Weekman EM (1862) Wilcock DM (2016) Homocysteine, homocysteinemia and vascular contributions to cognitive impairment and dementia (VCID). Biochim Biophys Acta 5:1008\u20131017","journal-title":"Biochim Biophys Acta"},{"key":"4679_CR11","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1007\/978-981-10-7632-9","volume-title":"The clinical application of homocysteine","author":"S Bhargava","year":"2018","unstructured":"Bhargava S (2018) Homocysteinemia and its neurological effects. In: Bhargava S (ed) The clinical application of homocysteine. Springer Books International, Cham, p 46"},{"issue":"4","key":"4679_CR12","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","volume":"53","author":"ZS Nasreddine","year":"2005","unstructured":"Nasreddine ZS, Phillips NA, B\u00e9dirian V, Charbonneau S, Whitehead V, Collin I, Cummings JL, Chertkow H (2005) The montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc 53(4):695\u2013699","journal-title":"J Am Geriatr Soc"},{"issue":"2","key":"4679_CR13","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1002\/wps.20050.PMID:23737408;PMCID:PMC3683251","volume":"12","author":"DA Regier","year":"2013","unstructured":"Regier DA, Kuhl EA, Kupfer DJ (2013) The DSM-5: classification and criteria changes. World Psychiatry 12(2):92\u201398. https:\/\/doi.org\/10.1002\/wps.20050.PMID:23737408;PMCID:PMC3683251","journal-title":"World Psychiatry"},{"issue":"2","key":"4679_CR14","doi-asserted-by":"publisher","first-page":"561","DOI":"10.3233\/JAD-171042.PMID:29480200;PMCID:PMC5836397","volume":"62","author":"AD Smith","year":"2018","unstructured":"Smith AD, Refsum H, Bottiglieri T, Fenech M, Hooshmand B, McCaddon A, Miller JW, Rosenberg IH, Obeid R (2018) Homocysteine and dementia: an international consensus statement. J Alzheimers Dis 62(2):561\u2013570. https:\/\/doi.org\/10.3233\/JAD-171042.PMID:29480200;PMCID:PMC5836397","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"4679_CR15","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s00401-011-0884-1","volume":"123","author":"EJ Mufson","year":"2012","unstructured":"Mufson EJ, Binder L, Counts SE, DeKosky ST, deTolledo-Morell L, Ginsberg SD, Ikonomovic MD, Perez SE, Scheff SW (2012) Mild cognitive impairment: pathology and mechanisms. Acta Neuropathol 123(1):13\u201330","journal-title":"Acta Neuropathol"},{"issue":"1","key":"4679_CR16","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s12291-017-0646-5.PMID:29371765;PMCID:PMC5766465","volume":"33","author":"S Bhargava","year":"2018","unstructured":"Bhargava S, Bhandari A, Choudhury S (2018) Role of homocysteine in cognitive impairement and alzheimer\u2019s disease. Indian J Clin Biochem 33(1):16\u201320. https:\/\/doi.org\/10.1007\/s12291-017-0646-5.PMID:29371765;PMCID:PMC5766465","journal-title":"Indian J Clin Biochem"},{"key":"4679_CR17","doi-asserted-by":"publisher","first-page":"427","DOI":"10.7326\/0003-4819-148-6-200803180-00005","volume":"148","author":"BL Plassman","year":"2008","unstructured":"Plassman BL, Langa KM, Fisher GG, Heeringa SG, Weir DR, Ofstedal MB, Burke JR, Hurd MD, Potter GG, Rodgers WL, Steffens DC, McArdle JJ, Willis RJ, Wallace RB (2008) Prevalence of cognitive impairment without dementia in the United States. Ann Intern Med 148:427\u2013434","journal-title":"Ann Intern Med"},{"key":"4679_CR18","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/ajcn\/80.1.114","volume":"80","author":"P Qadri","year":"2004","unstructured":"Qadri P, Fragiacomo C, Pezzati R, Zanda E, Forloni G, Tettamanti M, Lucca U (2004) Homocysteine, folate and vitamin B12 in mild cognitive impairment, Alzheimers disease and vascular dementia. Am J Clin Nutr 80:114\u2013122","journal-title":"Am J Clin Nutr"},{"key":"4679_CR19","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1475-2891-5-6","volume":"5","author":"A McCaddon","year":"2006","unstructured":"McCaddon A (2006) Homocysteine and cognitive impairment: a case series in general practice setting. Nutr J 5:6","journal-title":"Nutr J"},{"key":"4679_CR20","first-page":"CD004514","volume":"4","author":"R Malouf","year":"2003","unstructured":"Malouf R, Grimley EJ (2003) Folate with or without B12 for the prevention and treatment of healthy elderly and demented people. Cochrane Database Syst Rev. 4:CD004514","journal-title":"Cochrane Database Syst Rev."},{"issue":"2","key":"4679_CR21","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/s12291-021-00966-1","volume":"37","author":"S Bhargava","year":"2022","unstructured":"Bhargava S, Srivastava LM, Manocha A, Kankra M, Rawat S (2022) Micronutrient deficiencies and anemia in Urban India\u2014do we need food fortification? Ind J Clin Biochem 37(2):149\u2013158. https:\/\/doi.org\/10.1007\/s12291-021-00966-1","journal-title":"Ind J Clin Biochem"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-023-04679-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-023-04679-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-023-04679-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T21:41:58Z","timestamp":1729114918000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-023-04679-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,13]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["4679"],"URL":"https:\/\/doi.org\/10.1007\/s11010-023-04679-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-1725172\/v1","asserted-by":"object"}]},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,13]]},"assertion":[{"value":"4 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the institutional ethics committee under no: EC\/01\/16\/925.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual subjects included for participating in the study and publishing of the data as per the consent form approved by the ethics committee.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}