{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T13:09:29Z","timestamp":1724072969383},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1007\/s11010-023-04725-z","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T16:01:51Z","timestamp":1683043311000},"page":"567-577","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Regulation of Ras p21 and RalA GTPases activity by quinine in mammary epithelial cells"],"prefix":"10.1007","volume":"479","author":[{"given":"Vikram","family":"Bhatia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laya","family":"Esmati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajinder P.","family":"Bhullar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,5,2]]},"reference":[{"issue":"10","key":"4725_CR1","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1136\/hrt.2005.072280","volume":"91","author":"CP Wheeler-Jones","year":"2005","unstructured":"Wheeler-Jones CP (2005) Cell signalling in the cardiovascular system: an overview. Heart 91(10):1366\u20131374","journal-title":"Heart"},{"issue":"2","key":"4725_CR2","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1042\/BCJ20170441","volume":"476","author":"F McCormick","year":"2019","unstructured":"McCormick F (2019) Progress in targeting RAS with small molecule drugs. Biochem J 476(2):365\u2013374","journal-title":"Biochem J"},{"issue":"16","key":"4725_CR3","doi-asserted-by":"publisher","first-page":"4848","DOI":"10.1073\/pnas.79.16.4848","volume":"79","author":"EH Chang","year":"1982","unstructured":"Chang EH et al (1982) Human genome contains four genes homologous to transforming genes of Harvey and Kirsten murine sarcoma viruses. Proc Natl Acad Sci USA 79(16):4848\u20134852","journal-title":"Proc Natl Acad Sci USA"},{"issue":"29","key":"4725_CR4","doi-asserted-by":"publisher","first-page":"46717","DOI":"10.18632\/oncotarget.8773","volume":"7","author":"N Tsuchida","year":"2016","unstructured":"Tsuchida N, Murugan AK, Grieco M (2016) Kirsten Ras* oncogene: significance of its discovery in human cancer research. Oncotarget 7(29):46717\u201346733","journal-title":"Oncotarget"},{"issue":"7","key":"4725_CR5","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/nrm2438","volume":"9","author":"AE Karnoub","year":"2008","unstructured":"Karnoub AE, Weinberg RA (2008) Ras oncogenes: split personalities. Nat Rev Mol Cell Biol 9(7):517\u2013531","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"4725_CR6","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/nrc2109","volume":"7","author":"S Schubbert","year":"2007","unstructured":"Schubbert S, Shannon K, Bollag G (2007) Hyperactive Ras in developmental disorders and cancer. Nat Rev Cancer 7(4):295\u2013308","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"4725_CR7","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrc969","volume":"3","author":"J Downward","year":"2003","unstructured":"Downward J (2003) Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer 3(1):11\u201322","journal-title":"Nat Rev Cancer"},{"issue":"Pt 5","key":"4725_CR8","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1242\/jcs.01660","volume":"118","author":"K Wennerberg","year":"2005","unstructured":"Wennerberg K, Rossman KL, Der CJ (2005) The Ras superfamily at a glance. J Cell Sci 118(Pt 5):843\u2013846","journal-title":"J Cell Sci"},{"issue":"4","key":"4725_CR9","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1007\/s10555-020-09918-2","volume":"39","author":"L Buday","year":"2020","unstructured":"Buday L, Vas V (2020) Novel regulation of Ras proteins by direct tyrosine phosphorylation and dephosphorylation. Cancer Metastasis Rev 39(4):1067\u20131073","journal-title":"Cancer Metastasis Rev"},{"issue":"1","key":"4725_CR10","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1007\/s12017-018-8479-9","volume":"20","author":"S Veleri","year":"2018","unstructured":"Veleri S et al (2018) Molecular insights into the roles of Rab proteins in intracellular dynamics and neurodegenerative diseases. Neuromolecular Med 20(1):18\u201336","journal-title":"Neuromolecular Med"},{"issue":"1","key":"4725_CR11","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/BF00694753","volume":"35","author":"GJ Clark","year":"1995","unstructured":"Clark GJ, Der CJ (1995) Aberrant function of the Ras signal transduction pathway in human breast cancer. Breast Cancer Res Treat 35(1):133\u2013144","journal-title":"Breast Cancer Res Treat"},{"issue":"4","key":"4725_CR12","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S0962-8924(00)01740-2","volume":"10","author":"JM Shields","year":"2000","unstructured":"Shields JM et al (2000) Understanding Ras: \u2019it ain\u2019t over \u201ctil it\u2019s over.\u201d Trends Cell Biol 10(4):147\u2013154","journal-title":"Trends Cell Biol"},{"issue":"2","key":"4725_CR13","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1158\/0008-5472.CAN-16-0938","volume":"77","author":"AB Keeton","year":"2017","unstructured":"Keeton AB, Salter EA, Piazza GA (2017) The RAS-effector interaction as a drug target. Cancer Res 77(2):221\u2013226","journal-title":"Cancer Res"},{"issue":"42","key":"4725_CR14","doi-asserted-by":"publisher","first-page":"36460","DOI":"10.1074\/jbc.M111.262675","volume":"286","author":"K Hibino","year":"2011","unstructured":"Hibino K et al (2011) Activation kinetics of RAF protein in the ternary complex of RAF, RAS-GTP, and kinase on the plasma membrane of living cells: single-molecule imaging analysis. J Biol Chem 286(42):36460\u201336468","journal-title":"J Biol Chem"},{"issue":"3","key":"4725_CR15","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1158\/1535-7163.MCT-09-0560","volume":"9","author":"P Khanal","year":"2010","unstructured":"Khanal P et al (2010) The prolyl isomerase Pin1 enhances HER-2 expression and cellular transformation via its interaction with mitogen-activated protein kinase\/extracellular signal-regulated kinase kinase 1. Mol Cancer Ther 9(3):606\u2013616","journal-title":"Mol Cancer Ther"},{"issue":"1","key":"4725_CR16","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1517\/14728222.2011.645805","volume":"16","author":"L Santarpia","year":"2012","unstructured":"Santarpia L, Lippman SM, El-Naggar AK (2012) Targeting the MAPK-RAS-RAF signaling pathway in cancer therapy. Expert Opin Ther Targets 16(1):103\u2013119","journal-title":"Expert Opin Ther Targets"},{"issue":"4","key":"4725_CR17","first-page":"1966","volume":"39","author":"H Tian","year":"2018","unstructured":"Tian H et al (2018) Raf1 is a prognostic factor for progression in patients with nonsmall cell lung cancer after radiotherapy. Oncol Rep 39(4):1966\u20131974","journal-title":"Oncol Rep"},{"issue":"2","key":"4725_CR18","doi-asserted-by":"publisher","first-page":"L241","DOI":"10.1152\/ajplung.00093.2018","volume":"315","author":"S Li","year":"2018","unstructured":"Li S et al (2018) Inhibition of Raf1 ameliorates bleomycin-induced pulmonary fibrosis through attenuation of TGF-beta1 signaling. Am J Physiol Lung Cell Mol Physiol 315(2):L241\u2013L247","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"1","key":"4725_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0304-3835(01)00528-6","volume":"171","author":"K Pruitt","year":"2001","unstructured":"Pruitt K, Der CJ (2001) Ras and Rho regulation of the cell cycle and oncogenesis. Cancer Lett 171(1):1\u201310","journal-title":"Cancer Lett"},{"issue":"1","key":"4725_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.03.028","volume":"31","author":"M Hirayama","year":"2020","unstructured":"Hirayama M et al (2020) FTO demethylates cyclin D1 mRNA and controls cell-cycle progression. Cell Rep 31(1):107464","journal-title":"Cell Rep"},{"issue":"14","key":"4725_CR21","doi-asserted-by":"publisher","first-page":"22443","DOI":"10.18632\/oncotarget.12338","volume":"8","author":"JY Ho","year":"2017","unstructured":"Ho JY et al (2017) MicroRNA-382-5p aggravates breast cancer progression by regulating the RERG\/Ras\/ERK signaling axis. Oncotarget 8(14):22443\u201322459","journal-title":"Oncotarget"},{"issue":"3","key":"4725_CR22","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1002\/pro.3526","volume":"28","author":"X Edward Zhou","year":"2019","unstructured":"Edward Zhou X, Melcher K, Eric Xu H (2019) Structural biology of G protein-coupled receptor signaling complexes. Protein Sci 28(3):487\u2013501","journal-title":"Protein Sci"},{"key":"4725_CR23","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao3048","author":"LJ Bugaj","year":"2018","unstructured":"Bugaj LJ et al (2018) Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway. Science. https:\/\/doi.org\/10.1126\/science.aao3048","journal-title":"Science"},{"issue":"5","key":"4725_CR24","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1080\/14728222.2018.1465931","volume":"22","author":"JA Walker","year":"2018","unstructured":"Walker JA, Upadhyaya M (2018) Emerging therapeutic targets for neurofibromatosis type 1. Expert Opin Ther Targets 22(5):419\u2013437","journal-title":"Expert Opin Ther Targets"},{"issue":"29","key":"4725_CR25","doi-asserted-by":"publisher","first-page":"9948","DOI":"10.1074\/jbc.RA119.010981","volume":"295","author":"JA Mund","year":"2020","unstructured":"Mund JA et al (2020) Genetic disruption of the small GTPase RAC1 prevents plexiform neurofibroma formation in mice with neurofibromatosis type 1. J Biol Chem 295(29):9948\u20139958","journal-title":"J Biol Chem"},{"issue":"2","key":"4725_CR26","first-page":"645","volume":"20","author":"R Dammann","year":"2005","unstructured":"Dammann R et al (2005) The tumor suppressor RASSF1A in human carcinogenesis: an update. Histol Histopathol 20(2):645\u2013663","journal-title":"Histol Histopathol"},{"key":"4725_CR27","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1186\/1471-2407-10-253","volume":"10","author":"JH Tong","year":"2010","unstructured":"Tong JH et al (2010) Putative tumour-suppressor gene DAB2 is frequently down regulated by promoter hypermethylation in nasopharyngeal carcinoma. BMC Cancer 10:253","journal-title":"BMC Cancer"},{"issue":"1","key":"4725_CR28","doi-asserted-by":"publisher","first-page":"198","DOI":"10.3390\/cells9010198","volume":"9","author":"U Degirmenci","year":"2020","unstructured":"Degirmenci U, Wang M, Hu J (2020) Targeting Aberrant RAS\/RAF\/MEK\/ERK Signaling for Cancer Therapy. Cells 9(1):198","journal-title":"Cells"},{"issue":"3","key":"4725_CR29","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1177\/1947601911407329","volume":"2","author":"NF Neel","year":"2011","unstructured":"Neel NF et al (2011) The RalGEF-Ral effector signaling network: the road less travelled for anti-Ras drug discovery. Genes Cancer 2(3):275\u2013287","journal-title":"Genes Cancer"},{"issue":"3","key":"4725_CR30","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/aps.2014.129","volume":"36","author":"S Guin","year":"2015","unstructured":"Guin S, Theodorescu D (2015) The RAS-RAL axis in cancer: evidence for mutation-specific selectivity in non-small cell lung cancer. Acta Pharmacol Sin 36(3):291\u2013297","journal-title":"Acta Pharmacol Sin"},{"issue":"8","key":"4725_CR31","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/S0962-8924(03)00152-1","volume":"13","author":"LA Feig","year":"2003","unstructured":"Feig LA (2003) Ral-GTPases: approaching their 15 minutes of fame. Trends Cell Biol 13(8):419\u2013425","journal-title":"Trends Cell Biol"},{"issue":"2","key":"4725_CR32","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/nrc2296","volume":"8","author":"BO Bodemann","year":"2008","unstructured":"Bodemann BO, White MA (2008) Ral GTPases and cancer: linchpin support of the tumorigenic platform. Nat Rev Cancer 8(2):133\u2013140","journal-title":"Nat Rev Cancer"},{"issue":"9","key":"4725_CR33","doi-asserted-by":"publisher","first-page":"2316","DOI":"10.3324\/haematol.2019.223024","volume":"105","author":"M Seibold","year":"2020","unstructured":"Seibold M et al (2020) RAL GTPases mediate multiple myeloma cell survival and are activated independently of oncogenic RAS. Haematologica 105(9):2316\u20132326","journal-title":"Haematologica"},{"issue":"5","key":"4725_CR34","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1093\/jb\/mvv029","volume":"157","author":"R Shirakawa","year":"2015","unstructured":"Shirakawa R, Horiuchi H (2015) Ral GTPases: crucial mediators of exocytosis and tumourigenesis. J Biochem 157(5):285\u2013299","journal-title":"J Biochem"},{"issue":"2","key":"4725_CR35","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s10549-012-2289-9","volume":"136","author":"H Masuda","year":"2012","unstructured":"Masuda H et al (2012) Role of epidermal growth factor receptor in breast cancer. Breast Cancer Res Treat 136(2):331\u2013345","journal-title":"Breast Cancer Res Treat"},{"issue":"12","key":"4725_CR36","doi-asserted-by":"publisher","first-page":"2998","DOI":"10.1002\/cam4.1105","volume":"6","author":"AR Moghadam","year":"2017","unstructured":"Moghadam AR et al (2017) Ral signaling pathway in health and cancer. Cancer Med 6(12):2998\u20133013","journal-title":"Cancer Med"},{"issue":"1","key":"4725_CR37","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s13058-021-01438-3","volume":"23","author":"KA Thies","year":"2021","unstructured":"Thies KA et al (2021) The small G-protein RalA promotes progression and metastasis of triple-negative breast cancer. Breast Cancer Res 23(1):65","journal-title":"Breast Cancer Res"},{"key":"4725_CR38","doi-asserted-by":"publisher","first-page":"e61539","DOI":"10.7554\/eLife.61539","volume":"10","author":"S Ghoroghi","year":"2021","unstructured":"Ghoroghi S et al (2021) Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes. Elife 10:e61539","journal-title":"Elife"},{"issue":"2","key":"4725_CR39","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.bbrc.2014.02.140","volume":"446","author":"N Singh","year":"2014","unstructured":"Singh N et al (2014) Differential expression of bitter taste receptors in non-cancerous breast epithelial and breast cancer cells. Biochem Biophys Res Commun 446(2):499\u2013503","journal-title":"Biochem Biophys Res Commun"},{"issue":"13","key":"4725_CR40","doi-asserted-by":"publisher","first-page":"7131","DOI":"10.1073\/pnas.1913654117","volume":"117","author":"K Bum-Erdene","year":"2020","unstructured":"Bum-Erdene K et al (2020) Small-molecule covalent bond formation at tyrosine creates a binding site and inhibits activation of Ral GTPases. Proc Natl Acad Sci USA 117(13):7131\u20137139","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7527","key":"4725_CR41","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/nature13713","volume":"515","author":"C Yan","year":"2014","unstructured":"Yan C et al (2014) Discovery and characterization of small molecules that target the GTPase Ral. Nature 515(7527):443\u2013447","journal-title":"Nature"},{"issue":"2","key":"4725_CR42","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1111\/j.1747-0285.2007.00483.x","volume":"69","author":"T Halgren","year":"2007","unstructured":"Halgren T (2007) New method for fast and accurate binding-site identification and analysis. Chem Biol Drug Des 69(2):146\u2013148","journal-title":"Chem Biol Drug Des"},{"issue":"5","key":"4725_CR43","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/j.cell.2007.05.018","volume":"129","author":"JL Bos","year":"2007","unstructured":"Bos JL, Rehmann H, Wittinghofer A (2007) GEFs and GAPs: critical elements in the control of small G proteins. Cell 129(5):865\u2013877","journal-title":"Cell"},{"key":"4725_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jbior.2014.04.002","volume":"55","author":"O Maertens","year":"2014","unstructured":"Maertens O, Cichowski K (2014) An expanding role for RAS GTPase activating proteins (RAS GAPs) in cancer. Adv Biol Regul 55:1\u201314","journal-title":"Adv Biol Regul"},{"issue":"12","key":"4725_CR45","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1097\/JTO.0000000000000007","volume":"8","author":"S Guin","year":"2013","unstructured":"Guin S et al (2013) Contributions of KRAS and RAL in non-small-cell lung cancer growth and progression. J Thorac Oncol 8(12):1492\u20131501","journal-title":"J Thorac Oncol"},{"issue":"7","key":"4725_CR46","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1038\/onc.2012.101","volume":"32","author":"R Saito","year":"2013","unstructured":"Saito R et al (2013) Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer. Oncogene 32(7):894\u2013902","journal-title":"Oncogene"},{"issue":"4","key":"4725_CR47","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1158\/0008-5472.CAN-05-3855","volume":"66","author":"SC Smith","year":"2006","unstructured":"Smith SC et al (2006) The metastasis-associated gene CD24 is regulated by Ral GTPase and is a mediator of cell proliferation and survival in human cancer. Cancer Res 66(4):1917\u20131922","journal-title":"Cancer Res"},{"key":"4725_CR48","doi-asserted-by":"publisher","first-page":"5435831","DOI":"10.1155\/2017\/5435831","volume":"2017","author":"M Gilca","year":"2017","unstructured":"Gilca M, Dragos D (2017) Extraoral taste receptor discovery: new light on ayurvedic pharmacology. Evid Based Complement Altern Med 2017:5435831","journal-title":"Evid Based Complement Altern Med"},{"issue":"12","key":"4725_CR49","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1016\/j.cub.2010.04.043","volume":"20","author":"JP Slack","year":"2010","unstructured":"Slack JP et al (2010) Modulation of bitter taste perception by a small molecule hTAS2R antagonist. Curr Biol 20(12):1104\u20131109","journal-title":"Curr Biol"},{"issue":"1\u20132","key":"4725_CR50","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s11010-019-03679-5","volume":"465","author":"N Singh","year":"2020","unstructured":"Singh N et al (2020) Chemosensory bitter taste receptors T2R4 and T2R14 activation attenuates proliferation and migration of breast cancer cells. Mol Cell Biochem 465(1\u20132):199\u2013214","journal-title":"Mol Cell Biochem"},{"issue":"6","key":"4725_CR51","doi-asserted-by":"publisher","first-page":"501","DOI":"10.2174\/138920312803582942","volume":"13","author":"SP Pydi","year":"2012","unstructured":"Pydi SP et al (2012) Recent advances in structure and function studies on human bitter taste receptors. Curr Protein Pept Sci 13(6):501\u2013508","journal-title":"Curr Protein Pept Sci"},{"issue":"3","key":"4725_CR52","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1111\/j.1471-4159.2012.07808.x","volume":"122","author":"SP Pydi","year":"2012","unstructured":"Pydi SP, Bhullar RP, Chelikani P (2012) Constitutively active mutant gives novel insights into the mechanism of bitter taste receptor activation. J Neurochem 122(3):537\u2013544","journal-title":"J Neurochem"},{"issue":"5","key":"4725_CR53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0156347","volume":"11","author":"JD Upadhyaya","year":"2016","unstructured":"Upadhyaya JD et al (2016) The pharmacochaperone activity of quinine on bitter taste receptors. PLoS ONE 11(5):e0156347","journal-title":"PLoS ONE"},{"issue":"6","key":"4725_CR54","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1111\/eci.12441","volume":"45","author":"B Delire","year":"2015","unstructured":"Delire B, Starkel P (2015) The Ras\/MAPK pathway and hepatocarcinoma: pathogenesis and therapeutic implications. Eur J Clin Invest 45(6):609\u2013623","journal-title":"Eur J Clin Invest"},{"issue":"22","key":"4725_CR55","doi-asserted-by":"publisher","first-page":"3291","DOI":"10.1038\/sj.onc.1210422","volume":"26","author":"PJ Roberts","year":"2007","unstructured":"Roberts PJ, Der CJ (2007) Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene 26(22):3291\u20133310","journal-title":"Oncogene"},{"issue":"4","key":"4725_CR56","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.coph.2008.08.004","volume":"8","author":"TA Yap","year":"2008","unstructured":"Yap TA et al (2008) Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises. Curr Opin Pharmacol 8(4):393\u2013412","journal-title":"Curr Opin Pharmacol"},{"issue":"37","key":"4725_CR57","doi-asserted-by":"publisher","first-page":"22851","DOI":"10.1074\/jbc.M115.656710","volume":"290","author":"LR Gentry","year":"2015","unstructured":"Gentry LR et al (2015) Divergent roles of CAAX motif-signaled posttranslational modifications in the regulation and subcellular localization of Ral GTPases. J Biol Chem 290(37):22851\u201322861","journal-title":"J Biol Chem"},{"issue":"1\u20132","key":"4725_CR58","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s11010-016-2886-8","volume":"426","author":"C Sidhu","year":"2017","unstructured":"Sidhu C et al (2017) Regulation of Rac1 GTPase activity by quinine through G-protein and bitter taste receptor T2R4. Mol Cell Biochem 426(1\u20132):129\u2013136","journal-title":"Mol Cell Biochem"},{"issue":"2","key":"4725_CR59","doi-asserted-by":"publisher","first-page":"126","DOI":"10.4161\/sgtp.19571","volume":"3","author":"TD Martin","year":"2012","unstructured":"Martin TD, Der CJ (2012) Differential involvement of RalA and RalB in colorectal cancer. Small GTPases 3(2):126\u2013130","journal-title":"Small GTPases"},{"issue":"32","key":"4725_CR60","doi-asserted-by":"publisher","first-page":"28972","DOI":"10.1074\/jbc.M201504200","volume":"277","author":"RR Clough","year":"2002","unstructured":"Clough RR, Sidhu RS, Bhullar RP (2002) Calmodulin binds RalA and RalB and is required for the thrombin-induced activation of Ral in human platelets. J Biol Chem 277(32):28972\u201328980","journal-title":"J Biol Chem"},{"issue":"4","key":"4725_CR61","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1007\/BF00213527","volume":"172","author":"SR Barry","year":"1993","unstructured":"Barry SR, Bernal J (1993) Antimalarial drugs inhibit calcium-dependent backward swimming and calcium currents in Paramecium calkinsi. J Comp Physiol A 172(4):457\u2013466","journal-title":"J Comp Physiol A"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-023-04725-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-023-04725-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-023-04725-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T09:14:01Z","timestamp":1711185241000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-023-04725-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,2]]},"references-count":61,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["4725"],"URL":"https:\/\/doi.org\/10.1007\/s11010-023-04725-z","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,2]]},"assertion":[{"value":"21 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest. Co-authors have read the manuscript and agreed to submission to MCB journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}