{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T13:52:03Z","timestamp":1778593923695,"version":"3.51.4"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Beijing Municipal Natural Science Foundation","award":["7232228"],"award-info":[{"award-number":["7232228"]}]},{"name":"Institute for Intelligent Healthcare","award":["2022ZLB007"],"award-info":[{"award-number":["2022ZLB007"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Glioma is an intracranial tumor characterized by high mortality and recurrence rates. In the present study, the association of TRPM8 channel-associated factor 2 (TCAF2) in glioma was investigated using bioinformatics, showing significant relationships with age, WHO grade, IDH, and 1p\/19q status, as well as being an independent predictor of prognosis. Immunohistochemistry of a glioma sample microarray showed markedly increased TCAF2 expression in glioblastoma relative to lower-grade glioma, with elevated expression predominating in the tumor center. Raised TCAF2 levels promote glioma cell migratory\/invasion properties through the epithelial-to-mesenchymal transition-like (EMT-like) process, shown by Transwell and scratch assays and western blotting. It was further found that the effects of TCAF2 were mediated by the activation of STAT3. These results suggest that TCAF2 promotes glioma cell migration and invasion, rendering it a potential drug target in glioma therapy.<\/jats:p>","DOI":"10.1007\/s11010-023-04891-0","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T10:02:28Z","timestamp":1701252148000},"page":"1801-1815","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["TCAF2 drives glioma cellular migratory\/invasion properties through STAT3 signaling"],"prefix":"10.1007","volume":"479","author":[{"given":"Debo","family":"Yun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianshen","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuya","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jikang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xisen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiabo","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiude","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanjie","family":"Shang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenzhe","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengping","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,11,29]]},"reference":[{"issue":"3","key":"4891_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A et al (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209\u2013249","journal-title":"CA Cancer J Clin"},{"key":"4891_CR2","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.canlet.2020.10.050","volume":"499","author":"T Jiang","year":"2021","unstructured":"Jiang T, Nam DH, Ram Z, Poon WS, Wang J, Boldbaatar D et al (2021) Clinical practice guidelines for the management of adult diffuse gliomas. Cancer Lett 499:60\u201372","journal-title":"Cancer Lett"},{"issue":"4","key":"4891_CR3","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1093\/neuonc\/noz233","volume":"22","author":"AS Haider","year":"2020","unstructured":"Haider AS, van den Bent M, Wen PY, Vogelbaum MA, Chang S, Canoll PD et al (2020) Toward a standard pathological and molecular characterization of recurrent glioma in adults: a Response Assessment in Neuro-Oncology effort. Neuro Oncol 22(4):450\u2013456","journal-title":"Neuro Oncol"},{"issue":"1","key":"4891_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.radonc.2010.11.006","volume":"98","author":"M Niyazi","year":"2011","unstructured":"Niyazi M, Siefert A, Schwarz SB, Ganswindt U, Kreth FW, Tonn JC et al (2011) Therapeutic options for recurrent malignant glioma. Radiother Oncol 98(1):1\u201314","journal-title":"Radiother Oncol"},{"issue":"8","key":"4891_CR5","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","volume":"23","author":"DN Louis","year":"2021","unstructured":"Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D et al (2021) The 2021 WHO classification of tumors of the central nervous system: a summary. Neuro Oncol 23(8):1231\u20131251","journal-title":"Neuro Oncol"},{"issue":"3","key":"4891_CR6","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1083\/jcb.200412081","volume":"169","author":"EH Danen","year":"2005","unstructured":"Danen EH, van Rheenen J, Franken W, Huveneers S, Sonneveld P, Jalink K et al (2005) Integrins control motile strategy through a Rho-cofilin pathway. J Cell Biol 169(3):515\u2013526","journal-title":"J Cell Biol"},{"issue":"7","key":"4891_CR7","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/nrn3765","volume":"15","author":"VA Cuddapah","year":"2014","unstructured":"Cuddapah VA, Robel S, Watkins S, Sontheimer H (2014) A neurocentric perspective on glioma invasion. Nat Rev Neurosci 15(7):455\u2013465","journal-title":"Nat Rev Neurosci"},{"issue":"5","key":"4891_CR8","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/S1470-2045(09)70025-7","volume":"10","author":"R Stupp","year":"2009","unstructured":"Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJ, Janzer RC et al (2009) Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomized phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol 10(5):459\u2013466","journal-title":"Lancet Oncol"},{"issue":"3","key":"4891_CR9","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1001\/archneurol.2010.5","volume":"67","author":"J Clarke","year":"2010","unstructured":"Clarke J, Butowski N, Chang S (2010) Recent advances in therapy for glioblastoma. Arch Neurol 67(3):279\u2013283","journal-title":"Arch Neurol"},{"issue":"23","key":"4891_CR10","doi-asserted-by":"publisher","first-page":"2306","DOI":"10.1001\/jama.2017.18718","volume":"318","author":"R Stupp","year":"2017","unstructured":"Stupp R, Taillibert S, Kanner A, Read W, Steinberg D, Lhermitte B et al (2017) Effect of tumor-treating fields plus maintenance temozolomide vs maintenance temozolomide alone on survival in patients with glioblastoma: a randomized clinical trial. JAMA 318(23):2306\u20132316","journal-title":"JAMA"},{"issue":"5","key":"4891_CR11","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1517\/13543784.2012.670219","volume":"21","author":"K Seystahl","year":"2012","unstructured":"Seystahl K, Weller M (2012) Is there a world beyond Bevacizumab in targeting angiogenesis in glioblastoma? Expert Opin Investig Drugs 21(5):605\u2013617","journal-title":"Expert Opin Investig Drugs"},{"issue":"5","key":"4891_CR12","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1517\/14712598.2014.898060","volume":"14","author":"M Khasraw","year":"2014","unstructured":"Khasraw M, Ameratunga M, Grommes C (2014) Bevacizumab for the treatment of high-grade glioma: an update after phase III trials. Expert Opin Biol Ther 14(5):729\u2013740","journal-title":"Expert Opin Biol Ther"},{"issue":"1","key":"4891_CR13","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s13046-019-1085-3","volume":"38","author":"X Wang","year":"2019","unstructured":"Wang X, Guo G, Guan H, Yu Y, Lu J, Yu J (2019) Challenges and potential of PD-1\/PD-L1 checkpoint blockade immunotherapy for glioblastoma. J Exp Clin Cancer Res 38(1):87","journal-title":"J Exp Clin Cancer Res"},{"issue":"Pt 3","key":"4891_CR14","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.semcancer.2022.02.012","volume":"86","author":"I Preddy","year":"2022","unstructured":"Preddy I, Nandoliya K, Miska J, Ahmed AU (2022) Checkpoint: Inspecting the barriers in glioblastoma immunotherapies. Semin Cancer Biol 86(Pt 3):473\u2013481","journal-title":"Semin Cancer Biol"},{"issue":"1","key":"4891_CR15","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1083\/jcb.201402076","volume":"208","author":"D Gkika","year":"2015","unstructured":"Gkika D, Lemonnier L, Shapovalov G, Gordienko D, Poux C, Bernardini M et al (2015) TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity. J Cell Biol 208(1):89\u2013107","journal-title":"J Cell Biol"},{"key":"4891_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.617801","volume":"9","author":"G Chinigo","year":"2021","unstructured":"Chinigo G, Castel H, Chever O, Gkika D (2021) TRP channels in brain tumors. Front Cell Dev Biol 9:617801","journal-title":"Front Cell Dev Biol"},{"issue":"8","key":"4891_CR17","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.7150\/jca.38399","volume":"11","author":"K Saeki","year":"2020","unstructured":"Saeki K, Onishi H, Koga S, Ichimiya S, Nakayama K, Oyama Y et al (2020) FAM115C could be a novel tumor suppressor associated with prolonged survival in pancreatic cancer patients. J Cancer 11(8):2289\u20132302","journal-title":"J Cancer"},{"key":"4891_CR18","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202302717","author":"X Li","year":"2023","unstructured":"Li X, Qi Q, Li Y, Miao Q, Yin W, Pan J et al (2023) TCAF2 in pericytes promotes colorectal cancer liver metastasis via inhibiting cold-sensing TRPM8 channel. Adv Sci (Weinh). https:\/\/doi.org\/10.1002\/advs.202302717","journal-title":"Adv Sci (Weinh)"},{"key":"4891_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2023.147667","volume":"883","author":"Y Li","year":"2023","unstructured":"Li Y, Li J, Chen H, Lu B, Lu F, Chen H et al (2023) TCAF2 is associated with the immune microenvironment, promotes pathogenesis, and impairs prognosis in glioma. Gene 883:147667","journal-title":"Gene"},{"issue":"4","key":"4891_CR20","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1038\/nbt.3772","volume":"35","author":"J Vivian","year":"2017","unstructured":"Vivian J, Rao AA, Nothaft FA, Ketchum C, Armstrong J, Novak A et al (2017) Toil enables reproducible, open-source, big biomedical data analyses. Nat Biotechnol 35(4):314\u2013316","journal-title":"Nat Biotechnol"},{"issue":"3","key":"4891_CR21","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.cell.2015.12.028","volume":"164","author":"M Ceccarelli","year":"2016","unstructured":"Ceccarelli M, Barthel FP, Malta TM, Sabedot TS, Salama SR, Murray BA et al (2016) Molecular profiling reveals biologically discrete subsets and pathways of progression in diffuse glioma. Cell 164(3):550\u2013563","journal-title":"Cell"},{"key":"4891_CR22","unstructured":"Liu J, Lichtenberg T, Hoadley KA, Poisson LM, Lazar AJ, Cherniack AD, et al. An integrated TCGA pan-cancer clinical data resource to drive high-quality survival outcome analytics. Cell. 2018;173(2)."},{"issue":"1","key":"4891_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.gpb.2020.10.005","volume":"19","author":"Z Zhao","year":"2021","unstructured":"Zhao Z, Zhang KN, Wang Q, Li G, Zeng F, Zhang Y et al (2021) Chinese Glioma Genome Atlas (CGGA): A Comprehensive Resource with Functional Genomic Data from Chinese Glioma Patients. Genomics Proteomics Bioinformatics 19(1):1\u201312","journal-title":"Genomics Proteomics Bioinformatics"},{"issue":"5","key":"4891_CR24","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, Wang LG, Han Y, He QY (2012) clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS 16(5):284\u2013287","journal-title":"OMICS"},{"issue":"43","key":"4891_CR25","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA et al (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 102(43):15545\u201315550","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"4891_CR26","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1038\/s41419-017-0253-7","volume":"9","author":"T Li","year":"2018","unstructured":"Li T, Yi L, Hai L, Ma H, Tao Z, Zhang C et al (2018) The interactome and spatial redistribution feature of Ca(2+) receptor protein calmodulin reveals a novel role in invadopodia-mediated invasion. Cell Death Dis 9(3):292","journal-title":"Cell Death Dis"},{"key":"4891_CR27","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.canlet.2018.11.034","volume":"443","author":"Z Zhang","year":"2019","unstructured":"Zhang Z, Wang Z, Huang K, Liu Y, Wei C, Zhou J et al (2019) PLK4 is a determinant of temozolomide sensitivity through phosphorylation of IKBKE in glioblastoma. Cancer Lett 443:91\u2013107","journal-title":"Cancer Lett"},{"issue":"3","key":"4891_CR28","first-page":"336","volume":"19","author":"K Aldape","year":"2017","unstructured":"Aldape K, Nejad R, Louis DN, Zadeh G (2017) Integrating molecular markers into the World Health Organization classification of CNS tumors: a survey of the neuro-oncology community. Neuro Oncol 19(3):336\u2013344","journal-title":"Neuro Oncol"},{"issue":"7","key":"4891_CR29","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/s41583-018-0014-3","volume":"19","author":"D Laug","year":"2018","unstructured":"Laug D, Glasgow SM, Deneen B (2018) A glial blueprint for gliomagenesis. Nat Rev Neurosci 19(7):393\u2013403","journal-title":"Nat Rev Neurosci"},{"key":"4891_CR30","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3389\/fonc.2016.00060","volume":"6","author":"P Viswanath","year":"2016","unstructured":"Viswanath P, Chaumeil MM, Ronen SM (2016) Molecular imaging of metabolic reprograming in mutant IDH cells. Front Oncol 6:60","journal-title":"Front Oncol"},{"issue":"11","key":"4891_CR31","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1038\/s41416-020-0814-x","volume":"122","author":"S Han","year":"2020","unstructured":"Han S, Liu Y, Cai SJ, Qian M, Ding J, Larion M et al (2020) IDH mutation in glioma: molecular mechanisms and potential therapeutic targets. Br J Cancer 122(11):1580\u20131589","journal-title":"Br J Cancer"},{"issue":"10","key":"4891_CR32","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1001\/jamaneurol.2014.1205","volume":"71","author":"Z Turkalp","year":"2014","unstructured":"Turkalp Z, Karamchandani J, Das S (2014) IDH mutation in glioma: new insights and promises for the future. JAMA Neurol 71(10):1319\u20131325","journal-title":"JAMA Neurol"},{"issue":"5","key":"4891_CR33","first-page":"719","volume":"19","author":"SE van West","year":"2017","unstructured":"van West SE, de Bruin HG, van de Langerijt B, Swaak-Kragten AT, van den Bent MJ, Taal W (2017) Incidence of pseudoprogression in low-grade gliomas treated with radiotherapy. Neuro Oncol 19(5):719\u2013725","journal-title":"Neuro Oncol"},{"issue":"6","key":"4891_CR34","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1002\/cam4.2754","volume":"9","author":"G Li","year":"2020","unstructured":"Li G, Zhai Y, Wang Z, Wang Z, Huang R, Jiang H et al (2020) Postoperative standard chemoradiotherapy benefits primary glioblastoma patients of all ages. Cancer Med 9(6):1955\u20131965","journal-title":"Cancer Med"},{"issue":"1","key":"4891_CR35","volume":"3","author":"MK Wendt","year":"2014","unstructured":"Wendt MK, Balanis N, Carlin CR, Schiemann WP (2014) STAT3 and epithelial-mesenchymal transitions in carcinomas. JAKSTAT 3(1):e28975","journal-title":"JAKSTAT"},{"issue":"1","key":"4891_CR36","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1186\/s12935-021-02216-z","volume":"21","author":"FB Kang","year":"2021","unstructured":"Kang FB, Wang L, Jia HC, Li D, Li HJ, Zhang YG et al (2021) Correction to: B7\u2013H3 promotes aggression and invasion of hepatocellular carcinoma by targeting epithelial-to-mesenchymal transition via JAK2\/STAT3\/Slug signaling pathway. Cancer Cell Int 21(1):570","journal-title":"Cancer Cell Int"},{"issue":"5","key":"4891_CR37","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.3892\/ijo.2014.2310","volume":"44","author":"RY Liu","year":"2014","unstructured":"Liu RY, Zeng Y, Lei Z, Wang L, Yang H, Liu Z et al (2014) JAK\/STAT3 signaling is required for TGF-beta-induced epithelial-mesenchymal transition in lung cancer cells. Int J Oncol 44(5):1643\u20131651","journal-title":"Int J Oncol"},{"issue":"4","key":"4891_CR38","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1093\/brain\/awz044","volume":"142","author":"J Behnan","year":"2019","unstructured":"Behnan J, Finocchiaro G, Hanna G (2019) The landscape of the mesenchymal signature in brain tumours. Brain 142(4):847\u2013866","journal-title":"Brain"},{"issue":"3","key":"4891_CR39","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.ccr.2006.02.019","volume":"9","author":"HS Phillips","year":"2006","unstructured":"Phillips HS, Kharbanda S, Chen R, Forrest WF, Soriano RH, Wu TD et al (2006) Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 9(3):157\u2013173","journal-title":"Cancer Cell"},{"issue":"1","key":"4891_CR40","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1038\/s41467-019-14065-6","volume":"11","author":"R Li","year":"2020","unstructured":"Li R, Huang Y, Lin J (2020) Distinct effects of general anesthetics on lung metastasis mediated by IL-6\/JAK\/STAT3 pathway in mouse models. Nat Commun 11(1):642","journal-title":"Nat Commun"},{"issue":"30","key":"4891_CR41","doi-asserted-by":"publisher","first-page":"4094","DOI":"10.1038\/s41388-018-0250-z","volume":"37","author":"J Zhao","year":"2018","unstructured":"Zhao J, Du P, Cui P, Qin Y, Hu C, Wu J et al (2018) LncRNA PVT1 promotes angiogenesis via activating the STAT3\/VEGFA axis in gastric cancer. Oncogene 37(30):4094\u20134109","journal-title":"Oncogene"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-023-04891-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-023-04891-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-023-04891-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T07:29:28Z","timestamp":1721201368000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-023-04891-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,29]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["4891"],"URL":"https:\/\/doi.org\/10.1007\/s11010-023-04891-0","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,29]]},"assertion":[{"value":"3 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study was conducted following the Declaration of Helsinki and was approved by the ethical committee of Tianjin Medical University General Hospital (March 03, 2018).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All patients or relatives provided written informed consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}