{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:07:22Z","timestamp":1790233642199,"version":"4.1.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Agencia Nacional de Promoci\u00f3n Cientifica y Tecnologica","award":["PICT 2010-2581"],"award-info":[{"award-number":["PICT 2010-2581"]}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIP 11220200103056CO"],"award-info":[{"award-number":["PIP 11220200103056CO"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIP 11220090100636"],"award-info":[{"award-number":["PIP 11220090100636"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Agencia Nacional de Promoci\u00f3n Cientifica y Tecnologica)","award":["PICT 2010-0441"],"award-info":[{"award-number":["PICT 2010-0441"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1007\/s11010-024-05001-4","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T15:01:36Z","timestamp":1713366096000},"page":"937-949","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Valproate decreases transgenerationally blood pressure by affecting thyrotropin-releasing hormone promoter DNA methylation and gene expression in spontaneously hypertensive rat"],"prefix":"10.1007","volume":"480","author":[{"given":"Mar\u00eda S.","family":"Landa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano L.","family":"Schuman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maia","family":"Aisicovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila S.","family":"Peres Diaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariela M.","family":"Gironacci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia I.","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos J.","family":"Pirola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"5001_CR1","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1210\/endo-111-1-55","volume":"111","author":"RM Lechan","year":"1982","unstructured":"Lechan RM, Jackson IMD (1982) Immunohistochemical localization of thyrotropin-releasing hormone in the rat hypothalamus and pituitary*. Endocrinology 111:55\u201365. https:\/\/doi.org\/10.1210\/endo-111-1-55","journal-title":"Endocrinology"},{"key":"5001_CR2","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1002\/cne.22180","volume":"517","author":"G Wittmann","year":"2009","unstructured":"Wittmann G, F\u00fczesi T, Liposits Z et al (2009) Distribution and axonal projections of neurons coexpressing thyrotropin-releasing hormone and urocortin 3 in the rat brain. J Comp Neurol 517:825\u2013840. https:\/\/doi.org\/10.1002\/cne.22180","journal-title":"J Comp Neurol"},{"key":"5001_CR3","first-page":"209","volume-title":"Progress in brain research","author":"RM Lechan","year":"2006","unstructured":"Lechan RM, Fekete C (2006) The TRH neuron: a hypothalamic integrator of energy metabolism. Progress in brain research. Elsevier, Amsterdam, pp 209\u2013235"},{"key":"5001_CR4","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1161\/01.HYP.30.3.759","volume":"30","author":"SI Garc\u00eda","year":"1997","unstructured":"Garc\u00eda SI, Porto PI, Alvarez AL et al (1997) Central overexpression of the TRH precursor gene induces hypertension in rats: antisense reversal. Hypertension 30:759\u2013766. https:\/\/doi.org\/10.1161\/01.HYP.30.3.759","journal-title":"Hypertension"},{"key":"5001_CR5","doi-asserted-by":"publisher","first-page":"E1388","DOI":"10.1152\/ajpendo.00234.2006","volume":"292","author":"MS Landa","year":"2007","unstructured":"Landa MS, Garc\u00eda SI, Schuman ML et al (2007) Knocking down the diencephalic thyrotropin-releasing hormone precursor gene normalizes obesity-induced hypertension in the rat. Am J Physiol-Endocrinol Metab 292:E1388\u2013E1394. https:\/\/doi.org\/10.1152\/ajpendo.00234.2006","journal-title":"Am J Physiol-Endocrinol Metab"},{"key":"5001_CR6","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1016\/j.metabol.2007.06.008","volume":"56","author":"AL Burgue\u00f1o","year":"2007","unstructured":"Burgue\u00f1o AL, Landa MS, Schuman ML et al (2007) Association between diencephalic thyroliberin and arterial blood pressure in agouti-yellow and ob\/ob mice may be mediated by leptin. Metabolism 56:1439\u20131443. https:\/\/doi.org\/10.1016\/j.metabol.2007.06.008","journal-title":"Metabolism"},{"key":"5001_CR7","doi-asserted-by":"publisher","first-page":"3431","DOI":"10.2741\/2324","volume":"12","author":"MS Landa","year":"2007","unstructured":"Landa MS (2007) SiRNA-mediated silencing of the diencephalic thyrotropin-releasing hormone precursor gene decreases the arterial blood pressure in the obese agouti mice. Front Biosci 12:3431. https:\/\/doi.org\/10.2741\/2324","journal-title":"Front Biosci"},{"key":"5001_CR8","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s13105-020-00765-x","volume":"76","author":"MS Landa","year":"2020","unstructured":"Landa MS, Garc\u00eda SI, Schuman ML et al (2020) Cardiovascular and body weight regulation changes in transgenic mice overexpressing thyrotropin-releasing hormone (TRH). J Physiol Biochem 76:599\u2013608. https:\/\/doi.org\/10.1007\/s13105-020-00765-x","journal-title":"J Physiol Biochem"},{"key":"5001_CR9","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1161\/01.HYP.37.2.365","volume":"37","author":"SI Garc\u00eda","year":"2001","unstructured":"Garc\u00eda SI, Alvarez AL, Porto PI et al (2001) Antisense inhibition of thyrotropin-releasing hormone reduces arterial blood pressure in spontaneously hypertensive rats. Hypertension 37:365\u2013370. https:\/\/doi.org\/10.1161\/01.HYP.37.2.365","journal-title":"Hypertension"},{"key":"5001_CR10","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202051803","author":"Y Li","year":"2021","unstructured":"Li Y, Chen X, Lu C (2021) The interplay between DNA and histone methylation: molecular mechanisms and disease implications. EMBO Rep. https:\/\/doi.org\/10.15252\/embr.202051803","journal-title":"EMBO Rep"},{"key":"5001_CR11","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/sj.cr.7290337","volume":"15","author":"G Zardo","year":"2005","unstructured":"Zardo G, Fazi F, Travaglini L, Nervi C (2005) Dynamic and reversibility of heterochromatic gene silencing in human disease. Cell Res 15:679\u2013690. https:\/\/doi.org\/10.1038\/sj.cr.7290337","journal-title":"Cell Res"},{"key":"5001_CR12","doi-asserted-by":"publisher","first-page":"730","DOI":"10.4161\/epi.5.8.13053","volume":"5","author":"E Dong","year":"2010","unstructured":"Dong E, Chen Y, Gavin DP et al (2010) Valproate induces DNA demethylation in nuclear extracts from adult mouse brain. Epigenetics 5:730\u2013735. https:\/\/doi.org\/10.4161\/epi.5.8.13053","journal-title":"Epigenetics"},{"key":"5001_CR13","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1097\/WNR.0000000000000448","volume":"26","author":"S Aizawa","year":"2015","unstructured":"Aizawa S, Yamamuro Y (2015) Valproate administration to mice increases hippocampal p21 expression by altering genomic DNA methylation. NeuroReport 26:915\u2013920. https:\/\/doi.org\/10.1097\/WNR.0000000000000448","journal-title":"NeuroReport"},{"key":"5001_CR14","doi-asserted-by":"publisher","first-page":"1033035","DOI":"10.3389\/fonc.2022.1033035","volume":"12","author":"A-M Barciszewska","year":"2022","unstructured":"Barciszewska A-M, Belter A, Gawro\u0144ska I et al (2022) Cross-reactivity between histone demethylase inhibitor valproic acid and DNA methylation in glioblastoma cell lines. Front Oncol 12:1033035. https:\/\/doi.org\/10.3389\/fonc.2022.1033035","journal-title":"Front Oncol"},{"key":"5001_CR15","doi-asserted-by":"publisher","first-page":"033310242211463","DOI":"10.1177\/03331024221146317","volume":"43","author":"M Vila-Pueyo","year":"2023","unstructured":"Vila-Pueyo M, Cuenca-Le\u00f3n E, Queir\u00f3s AC et al (2023) Genome-wide DNA methylation analysis in an antimigraine-treated preclinical model of cortical spreading depolarization. Cephalalgia 43:033310242211463. https:\/\/doi.org\/10.1177\/03331024221146317","journal-title":"Cephalalgia"},{"key":"5001_CR16","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1161\/HYPERTENSIONAHA.110.154567","volume":"56","author":"JP Cardinale","year":"2010","unstructured":"Cardinale JP, Sriramula S, Pariaut R et al (2010) HDAC inhibition attenuates inflammatory, hypertrophic, and hypertensive responses in spontaneously hypertensive rats. Hypertension 56:437\u2013444. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.110.154567","journal-title":"Hypertension"},{"key":"5001_CR17","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1097\/00005344-199005000-00004","volume":"15","author":"S Sasaki","year":"1990","unstructured":"Sasaki S, Nakata T, Kawasaki S et al (1990) Chronic central GABAergic stimulation attenuates hypothalamic hyperactivity and development of spontaneous hypertension in rats. J Cardiovasc Pharmacol 15:706\u2013713. https:\/\/doi.org\/10.1097\/00005344-199005000-00004","journal-title":"J Cardiovasc Pharmacol"},{"key":"5001_CR18","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1006\/abio.1987.9999","volume":"162","author":"P Chomzynski","year":"1987","unstructured":"Chomzynski P (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate\u2013phenol\u2013chloroform extraction. Anal Biochem 162:156\u2013159. https:\/\/doi.org\/10.1006\/abio.1987.9999","journal-title":"Anal Biochem"},{"key":"5001_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118346","volume":"261","author":"LS Peres Diaz","year":"2020","unstructured":"Peres Diaz LS, Schuman ML, Aisicovich M et al (2020) Short-term doxorubicin cardiotoxic effects: involvement of cardiac thyrotropin releasing hormone system. Life Sci 261:118346. https:\/\/doi.org\/10.1016\/j.lfs.2020.118346","journal-title":"Life Sci"},{"key":"5001_CR20","first-page":"71","volume":"3","author":"X Rao","year":"2013","unstructured":"Rao X, Huang X, Zhou Z, Lin X (2013) An improvement of the 2\u2212\u2206\u2206CT method for quantitative real-time polymerase chain reaction data analysis. Biostat Bioinforma Biomath 3:71\u201385","journal-title":"Biostat Bioinforma Biomath"},{"key":"5001_CR21","first-page":"146","volume-title":"PCR protocols","author":"ES Kawasaki","year":"1990","unstructured":"Kawasaki ES (1990) Sample preparation from blood, cells, and other fluids. PCR protocols. Elsevier, Amsterdam, pp 146\u2013152"},{"key":"5001_CR22","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1093\/bioinformatics\/18.11.1427","volume":"18","author":"L-C Li","year":"2002","unstructured":"Li L-C, Dahiya R (2002) MethPrimer: designing primers for methylation PCRs. Bioinformatics 18:1427\u20131431. https:\/\/doi.org\/10.1093\/bioinformatics\/18.11.1427","journal-title":"Bioinformatics"},{"key":"5001_CR23","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.ymgme.2010.02.004","volume":"100","author":"C Gemma","year":"2010","unstructured":"Gemma C, Sookoian S, Dieuzeide G et al (2010) Methylation of TFAM gene promoter in peripheral white blood cells is associated with insulin resistance in adolescents. Mol Genet Metab 100:83\u201387. https:\/\/doi.org\/10.1016\/j.ymgme.2010.02.004","journal-title":"Mol Genet Metab"},{"key":"5001_CR24","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1111\/j.1471-4159.2009.05912.x","volume":"109","author":"MA Lopez Verrilli","year":"2009","unstructured":"Lopez Verrilli MA, Pirola CJ, Pascual MM et al (2009) Angiotensin-(1\u20137) through AT2 receptors mediates tyrosine hydroxylase degradation via the ubiquitin-proteasome pathway. J Neurochem 109:326\u2013335. https:\/\/doi.org\/10.1111\/j.1471-4159.2009.05912.x","journal-title":"J Neurochem"},{"key":"5001_CR25","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1046\/j.0022-3042.2001.00728.x","volume":"80","author":"R Hashimoto","year":"2002","unstructured":"Hashimoto R, Hough C, Nakazawa T et al (2002) Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation. J Neurochem 80:589\u2013597. https:\/\/doi.org\/10.1046\/j.0022-3042.2001.00728.x","journal-title":"J Neurochem"},{"key":"5001_CR26","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.yfrne.2010.01.001","volume":"31","author":"EA Nillni","year":"2010","unstructured":"Nillni EA (2010) Regulation of the hypothalamic thyrotropin releasing hormone (TRH) neuron by neuronal and peripheral inputs. Front Neuroendocrinol 31:134\u2013156. https:\/\/doi.org\/10.1016\/j.yfrne.2010.01.001","journal-title":"Front Neuroendocrinol"},{"key":"5001_CR27","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1111\/j.1365-2826.2010.01966.x","volume":"22","author":"MY D\u00edaz-Gallardo","year":"2010","unstructured":"D\u00edaz-Gallardo MY, Cote-V\u00e9lez A, Charli JL, Joseph-Bravo P (2010) A rapid interference between glucocorticoids and cAMP-activated signalling in hypothalamic neurones prevents binding of phosphorylated cAMP response element binding protein and glucocorticoid receptor at the CRE-like and composite GRE sites of thyrotrophin-releasing hormone gene promoter. J Neuroendocrinol 22:282\u2013293. https:\/\/doi.org\/10.1111\/j.1365-2826.2010.01966.x","journal-title":"J Neuroendocrinol"},{"key":"5001_CR28","doi-asserted-by":"publisher","first-page":"E39","DOI":"10.1152\/ajpendo.00267.2017","volume":"314","author":"H-A Lee","year":"2018","unstructured":"Lee H-A, Kang S-H, Kim M et al (2018) Histone deacetylase inhibition ameliorates hypertension and hyperglycemia in a model of Cushing\u2019s syndrome. Am J Physiol-Endocrinol Metab 314:E39\u2013E52. https:\/\/doi.org\/10.1152\/ajpendo.00267.2017","journal-title":"Am J Physiol-Endocrinol Metab"},{"key":"5001_CR29","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.1038\/ijo.2017.166","volume":"41","author":"J Choi","year":"2017","unstructured":"Choi J, Park S, Kwon TK et al (2017) Role of the histone deacetylase inhibitor valproic acid in high-fat diet-induced hypertension via inhibition of HDAC1\/angiotensin II axis. Int J Obes 41:1702\u20131709. https:\/\/doi.org\/10.1038\/ijo.2017.166","journal-title":"Int J Obes"},{"key":"5001_CR30","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.peptides.2004.01.016","volume":"25","author":"AE Pekary","year":"2004","unstructured":"Pekary AE, Sattin A, Meyerhoff JL, Chilingar M (2004) Valproate modulates TRH receptor, TRH and TRH-like peptide levels in rat brain. Peptides 25:647\u2013658. https:\/\/doi.org\/10.1016\/j.peptides.2004.01.016","journal-title":"Peptides"},{"key":"5001_CR31","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.bbrc.2015.12.048","volume":"469","author":"S Kameshima","year":"2016","unstructured":"Kameshima S, Okada M, Yamawaki H (2016) Expression and localization of calmodulin-related proteins in brain, heart and kidney from spontaneously hypertensive rats. Biochem Biophys Res Commun 469:654\u2013658. https:\/\/doi.org\/10.1016\/j.bbrc.2015.12.048","journal-title":"Biochem Biophys Res Commun"},{"key":"5001_CR32","doi-asserted-by":"publisher","first-page":"e600","DOI":"10.1038\/tp.2015.90","volume":"5","author":"RS Lee","year":"2015","unstructured":"Lee RS, Pirooznia M, Guintivano J et al (2015) Search for common targets of lithium and valproic acid identifies novel epigenetic effects of lithium on the rat leptin receptor gene. Transl Psychiatry 5:e600\u2013e600. https:\/\/doi.org\/10.1038\/tp.2015.90","journal-title":"Transl Psychiatry"},{"key":"5001_CR33","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1097\/CAD.0b013e32835739dd","volume":"23","author":"S Gu","year":"2012","unstructured":"Gu S, Tian Y, Chlenski A et al (2012) Valproic acid shows a potent antitumor effect with alteration of DNA methylation in neuroblastoma. Anticancer Drugs 23:1054\u20131066. https:\/\/doi.org\/10.1097\/CAD.0b013e32835739dd","journal-title":"Anticancer Drugs"},{"key":"5001_CR34","doi-asserted-by":"publisher","first-page":"e371","DOI":"10.1016\/S2666-7568(21)00061-1","volume":"2","author":"J Pedro Ferreira","year":"2021","unstructured":"Pedro Ferreira J, Pitt B, Zannad F (2021) Histone deacetylase inhibitors for cardiovascular conditions and healthy longevity. Lancet Healthy Longevity 2:e371\u2013e379. https:\/\/doi.org\/10.1016\/S2666-7568(21)00061-1","journal-title":"Lancet Healthy Longevity"},{"key":"5001_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.121577","volume":"321","author":"Y Xin","year":"2023","unstructured":"Xin Y, Sun X, Ren L et al (2023) Maternal preconceptional inflammation transgenerationally alters metabolic and behavioral phenotypes in offspring. Life Sci 321:121577. https:\/\/doi.org\/10.1016\/j.lfs.2023.121577","journal-title":"Life Sci"},{"key":"5001_CR36","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s12916-014-0153-y","volume":"12","author":"MK Skinner","year":"2014","unstructured":"Skinner MK (2014) Environmental stress and epigenetic transgenerational inheritance. BMC Med 12:153. https:\/\/doi.org\/10.1186\/s12916-014-0153-y","journal-title":"BMC Med"},{"key":"5001_CR37","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1111\/1440-1681.12303","volume":"41","author":"JS Master","year":"2014","unstructured":"Master JS, Zimanyi MA, Yin KV et al (2014) Transgenerational left ventricular hypertrophy and hypertension in offspring after uteroplacental insufficiency in male rats. Clin Exp Pharmacol Physiol 41:884\u2013890. https:\/\/doi.org\/10.1111\/1440-1681.12303","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"5001_CR38","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1017\/S2040174411000055","volume":"2","author":"SR de Rooij","year":"2011","unstructured":"de Rooij SR, Painter RC, Phillips DI et al (2011) Self-reported depression and anxiety after prenatal famine exposure: mediation by cardio-metabolic pathology? J Devel Orig Health Dis 2:136\u2013143. https:\/\/doi.org\/10.1017\/S2040174411000055","journal-title":"J Devel Orig Health Dis"},{"key":"5001_CR39","doi-asserted-by":"publisher","first-page":"2228","DOI":"10.1210\/en.2010-1461","volume":"152","author":"GA Dunn","year":"2011","unstructured":"Dunn GA, Bale TL (2011) Maternal high-fat diet effects on third-generation female body size via the paternal lineage. Endocrinology 152:2228\u20132236. https:\/\/doi.org\/10.1210\/en.2010-1461","journal-title":"Endocrinology"},{"key":"5001_CR40","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1126\/science.1108190","volume":"308","author":"MD Anway","year":"2005","unstructured":"Anway MD, Cupp AS, Uzumcu M, Skinner MK (2005) Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science 308:1466\u20131469. https:\/\/doi.org\/10.1126\/science.1108190","journal-title":"Science"},{"key":"5001_CR41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013100","volume":"5","author":"C Guerrero-Bosagna","year":"2010","unstructured":"Guerrero-Bosagna C, Settles M, Lucker B, Skinner MK (2010) Epigenetic transgenerational actions of vinclozolin on promoter regions of the sperm epigenome. PLoS ONE 5:e13100. https:\/\/doi.org\/10.1371\/journal.pone.0013100","journal-title":"PLoS ONE"},{"key":"5001_CR42","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/s41421-021-00343-5","volume":"7","author":"X Zheng","year":"2021","unstructured":"Zheng X, Li Z, Wang G et al (2021) Sperm epigenetic alterations contribute to inter- and transgenerational effects of paternal exposure to long-term psychological stress via evading offspring embryonic reprogramming. Cell Discov 7:101. https:\/\/doi.org\/10.1038\/s41421-021-00343-5","journal-title":"Cell Discov"},{"key":"5001_CR43","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1415195112","author":"H Jia","year":"2015","unstructured":"Jia H, Morris CD, Williams RM et al (2015) HDAC inhibition imparts beneficial transgenerational effects in Huntington\u2019s disease mice via altered DNA and histone methylation. Proc Natl Acad Sci USA. https:\/\/doi.org\/10.1073\/pnas.1415195112","journal-title":"Proc Natl Acad Sci USA"},{"key":"5001_CR44","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1161\/01.HYP.22.2.139","volume":"22","author":"JN Wu","year":"1993","unstructured":"Wu JN, Berecek KH (1993) Prevention of genetic hypertension by early treatment of spontaneously hypertensive rats with the angiotensin converting enzyme inhibitor captopril. Hypertension 22:139\u2013146. https:\/\/doi.org\/10.1161\/01.HYP.22.2.139","journal-title":"Hypertension"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-024-05001-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-024-05001-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-024-05001-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T14:12:44Z","timestamp":1739887964000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-024-05001-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,17]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["5001"],"URL":"https:\/\/doi.org\/10.1007\/s11010-024-05001-4","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,17]]},"assertion":[{"value":"14 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}