{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:42:02Z","timestamp":1787503322576,"version":"build-2736575974"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T00:00:00Z","timestamp":1716595200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T00:00:00Z","timestamp":1716595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Dan He","award":["CBYI202103"],"award-info":[{"award-number":["CBYI202103"]}]},{"name":"Dan He","award":["2021YJ0204"],"award-info":[{"award-number":["2021YJ0204"]}]},{"name":"Dan He","award":["Q19034"],"award-info":[{"award-number":["Q19034"]}]},{"name":"Jingyi Li","award":["2022ZYD0073"],"award-info":[{"award-number":["2022ZYD0073"]}]},{"name":"Jingyi Li","award":["2022-YF05-01504- SN"],"award-info":[{"award-number":["2022-YF05-01504- SN"]}]},{"name":"Jingyi Li","award":["2022LHFSZYB-02"],"award-info":[{"award-number":["2022LHFSZYB-02"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s11010-024-05030-z","type":"journal-article","created":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T06:01:37Z","timestamp":1716616897000},"page":"2277-2290","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Swertiamarin relieves radiation-induced intestinal injury by limiting DNA damage"],"prefix":"10.1007","volume":"480","author":[{"given":"Zhe","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,25]]},"reference":[{"issue":"10","key":"5030_CR1","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1046\/j.1365-2036.2003.01760.x","volume":"18","author":"B Gami","year":"2003","unstructured":"Gami B, Harrington K, Blake P, Dearnaley D, Tait D, Davies J, Norman AR, Andreyev HJ (2003) How patients manage gastrointestinal symptoms after pelvic radiotherapy. Aliment Pharmacol Ther 18(10):987\u2013994. https:\/\/doi.org\/10.1046\/j.1365-2036.2003.01760.x","journal-title":"Aliment Pharmacol Ther"},{"issue":"11","key":"5030_CR2","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/s1470-2045(07)70341-8","volume":"8","author":"J Andreyev","year":"2007","unstructured":"Andreyev J (2007) Gastrointestinal symptoms after pelvic radiotherapy: a new understanding to improve management of symptomatic patients. Lancet Oncol 8(11):1007\u20131017. https:\/\/doi.org\/10.1016\/s1470-2045(07)70341-8","journal-title":"Lancet Oncol"},{"issue":"1","key":"5030_CR3","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1136\/flgastro-2014-100468","volume":"6","author":"HJ Andreyev","year":"2015","unstructured":"Andreyev HJ, Muls AC, Norton C, Ralph C, Watson L, Shaw C, Lindsay JO (2015) Guidance: the practical management of the gastrointestinal symptoms of pelvic radiation disease. Frontline Gastroenterol 6(1):53\u201372. https:\/\/doi.org\/10.1136\/flgastro-2014-100468","journal-title":"Frontline Gastroenterol"},{"issue":"1","key":"5030_CR4","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1097\/SPC.0b013e328343ad2f","volume":"5","author":"LJ Wedlake","year":"2011","unstructured":"Wedlake LJ, Andreyev HJ (2011) Manipulating the consequential effect: an alternative approach to reducing pelvic radiation disease other than dose reduction. Curr Opin Support Palliat Care 5(1):25\u201328. https:\/\/doi.org\/10.1097\/SPC.0b013e328343ad2f","journal-title":"Curr Opin Support Palliat Care"},{"issue":"1","key":"5030_CR5","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.eururo.2011.09.027","volume":"61","author":"L Bud\u00e4us","year":"2012","unstructured":"Bud\u00e4us L, Bolla M, Bossi A, Cozzarini C, Crook J, Widmark A, Wiegel T (2012) Functional outcomes and complications following radiation therapy for prostate cancer: a critical analysis of the literature. Eur Urol 61(1):112\u2013127. https:\/\/doi.org\/10.1016\/j.eururo.2011.09.027","journal-title":"Eur Urol"},{"issue":"4","key":"5030_CR6","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/s1470-2045(10)70026-7","volume":"11","author":"HJ Andreyev","year":"2010","unstructured":"Andreyev HJ, Wotherspoon A, Denham JW, Hauer-Jensen M (2010) Defining pelvic-radiation disease for the survivorship era. Lancet Oncol 11(4):310\u2013312. https:\/\/doi.org\/10.1016\/s1470-2045(10)70026-7","journal-title":"Lancet Oncol"},{"issue":"6","key":"5030_CR7","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1634\/theoncologist.12-6-738","volume":"12","author":"JR Kouvaris","year":"2007","unstructured":"Kouvaris JR, Kouloulias VE, Vlahos LJ (2007) Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist 12(6):738\u2013747. https:\/\/doi.org\/10.1634\/theoncologist.12-6-738","journal-title":"Oncologist"},{"issue":"2\u20133","key":"5030_CR8","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.phymed.2008.09.010","volume":"16","author":"V Jaishree","year":"2009","unstructured":"Jaishree V, Badami S, Rupesh Kumar M, Tamizhmani T (2009) Antinociceptive activity of swertiamarin isolated from Enicostemma axillare. Phytomedicine 16(2\u20133):227\u2013232. https:\/\/doi.org\/10.1016\/j.phymed.2008.09.010","journal-title":"Phytomedicine"},{"issue":"3","key":"5030_CR9","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1248\/bpb.28.534","volume":"28","author":"JC Li","year":"2005","unstructured":"Li JC, Feng L, Sun BH, Ikeda T, Nohara T (2005) Hepatoprotective activity of the constituents in Swertia pseudochinensis. Biol Pharm Bull 28(3):534\u2013537. https:\/\/doi.org\/10.1248\/bpb.28.534","journal-title":"Biol Pharm Bull"},{"issue":"3","key":"5030_CR10","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1002\/ptr.1434","volume":"18","author":"UM Upadhyay","year":"2004","unstructured":"Upadhyay UM, Goyal RK (2004) Efficacy of Enicostemma littorale in Type 2 diabetic patients. Phytother Res 18(3):233\u2013235. https:\/\/doi.org\/10.1002\/ptr.1434","journal-title":"Phytother Res"},{"issue":"1","key":"5030_CR11","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.jep.2010.04.019","volume":"130","author":"V Jaishree","year":"2010","unstructured":"Jaishree V, Badami S (2010) Antioxidant and hepatoprotective effect of swertiamarin from Enicostemma axillare against d-galactosamine induced acute liver damage in rats. J Ethnopharmacol 130(1):103\u2013106. https:\/\/doi.org\/10.1016\/j.jep.2010.04.019","journal-title":"J Ethnopharmacol"},{"issue":"3","key":"5030_CR12","first-page":"235","volume":"46","author":"MF Sullivan","year":"1965","unstructured":"Sullivan MF, Hulse EV, Mole RH (1965) The mucus-depleting action of bile in the small intestine of the irradiated rat. Br J Exp Pathol 46(3):235\u2013244","journal-title":"Br J Exp Pathol"},{"issue":"11","key":"5030_CR13","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1002\/1097-0142(19841201)54:11<2396::AID-CNCR2820541115>3.0.CO;2-3","volume":"54","author":"MW Mulholland","year":"1984","unstructured":"Mulholland MW, Levitt SH, Song CW, Potish RA, Delaney JP (1984) The role of luminal contents in radiation enteritis. Cancer 54(11):2396\u20132402","journal-title":"Cancer"},{"issue":"2","key":"5030_CR14","doi-asserted-by":"crossref","first-page":"175","DOI":"10.2307\/3579575","volume":"148","author":"P Scanff","year":"1997","unstructured":"Scanff P, Grison S, Monti P, Joubert C, Griffiths NM, Gourmelon P (1997) Whole-body gamma irradiation modifies bile composition in the pig. Radiat Res 148(2):175\u2013180","journal-title":"Radiat Res"},{"issue":"2","key":"5030_CR15","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1080\/095530099140663","volume":"75","author":"P Scanff","year":"1999","unstructured":"Scanff P, Monti P, Joubert C, Grison S, Gourmelon P, Griffiths NM (1999) Modified bile acid profiles in mixed neutron and gamma-irradiated pigs. Int J Radiat Biol 75(2):209\u2013216. https:\/\/doi.org\/10.1080\/095530099140663","journal-title":"Int J Radiat Biol"},{"issue":"1","key":"5030_CR16","first-page":"12","volume":"17","author":"H Vaidya","year":"2012","unstructured":"Vaidya H, Giri S, Jain M, Goyal R (2012) Decrease in serum matrix metalloproteinase-9 and matrix metalloproteinase-3 levels in Zucker fa\/fa obese rats after treatment with swertiamarin. Exp Clin Cardiol 17(1):12\u201316","journal-title":"Exp Clin Cardiol"},{"issue":"8","key":"5030_CR17","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1002\/ptr.3708","volume":"26","author":"H Vaidya","year":"2012","unstructured":"Vaidya H, Prajapati A, Rajani M, Sudarsanam V, Padh H, Goyal RK (2012) Beneficial effects of swertiamarin on dyslipidaemia in streptozotocin-induced type 2 diabetic rats. Phytother Res 26(8):1259\u20131261. https:\/\/doi.org\/10.1002\/ptr.3708","journal-title":"Phytother Res"},{"key":"5030_CR18","doi-asserted-by":"publisher","first-page":"s15","DOI":"10.5604\/01.3001.0010.5494","volume":"16","author":"O Ram\u00edrez-P\u00e9rez","year":"2017","unstructured":"Ram\u00edrez-P\u00e9rez O, Cruz-Ram\u00f3n V, Chinchilla-L\u00f3pez P, M\u00e9ndez-S\u00e1nchez N (2017) The role of the gut microbiota in bile acid metabolism. Ann Hepatol 16:s15\u2013s20. https:\/\/doi.org\/10.5604\/01.3001.0010.5494","journal-title":"Ann Hepatol"},{"issue":"6121","key":"5030_CR19","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1126\/science.1232458","volume":"339","author":"L Sun","year":"2013","unstructured":"Sun L, Wu J, Du F, Chen X, Chen ZJ (2013) Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 339(6121):786\u2013791. https:\/\/doi.org\/10.1126\/science.1232458","journal-title":"Science"},{"issue":"6121","key":"5030_CR20","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1126\/science.1229963","volume":"339","author":"J Wu","year":"2013","unstructured":"Wu J, Sun L, Chen X, Du F, Shi H, Chen C, Chen ZJ (2013) Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science 339(6121):826\u2013830. https:\/\/doi.org\/10.1126\/science.1229963","journal-title":"Science"},{"issue":"6","key":"5030_CR21","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1016\/j.immuni.2021.05.008","volume":"54","author":"L Shmuel-Galia","year":"2021","unstructured":"Shmuel-Galia L, Humphries F, Lei X, Ceglia S, Wilson R, Jiang Z, Ketelut-Carneiro N, Foley SE, Pechhold S, Houghton J, Muneeruddin K, Shaffer SA, McCormick BA, Reboldi A, Ward D, Marshak-Rothstein A, Fitzgerald KA (2021) Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells. Immunity 54(6):1137-1153.e1138. https:\/\/doi.org\/10.1016\/j.immuni.2021.05.008","journal-title":"Immunity"},{"issue":"5","key":"5030_CR22","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1016\/j.immuni.2014.10.017","volume":"41","author":"SR Woo","year":"2014","unstructured":"Woo SR, Fuertes MB, Corrales L, Spranger S, Furdyna MJ, Leung MY, Duggan R, Wang Y, Barber GN, Fitzgerald KA, Alegre ML, Gajewski TF (2014) STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors. Immunity 41(5):830\u2013842. https:\/\/doi.org\/10.1016\/j.immuni.2014.10.017","journal-title":"Immunity"},{"issue":"7668","key":"5030_CR23","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/nature23449","volume":"548","author":"KJ Mackenzie","year":"2017","unstructured":"Mackenzie KJ, Carroll P, Martin CA, Murina O, Fluteau A, Simpson DJ, Olova N, Sutcliffe H, Rainger JK, Leitch A, Osborn RT, Wheeler AP, Nowotny M, Gilbert N, Chandra T, Reijns MAM, Jackson AP (2017) cGAS surveillance of micronuclei links genome instability to innate immunity. Nature 548(7668):461\u2013465. https:\/\/doi.org\/10.1038\/nature23449","journal-title":"Nature"},{"issue":"10","key":"5030_CR24","doi-asserted-by":"publisher","first-page":"2076","DOI":"10.1016\/j.cmet.2021.07.009","volume":"33","author":"R Liu","year":"2021","unstructured":"Liu R, Li J, Shao J, Lee JH, Qiu X, Xiao Y, Zhang B, Hao Y, Li M, Chen Q (2021) Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair. Cell Metab 33(10):2076-2089.e2079. https:\/\/doi.org\/10.1016\/j.cmet.2021.07.009","journal-title":"Cell Metab"},{"issue":"1","key":"5030_CR25","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/s13046-022-02334-0","volume":"41","author":"J Zhang","year":"2022","unstructured":"Zhang J, Chen M, Pang Y, Cheng M, Huang B, Xu S, Liu M, Lian H, Zhong C (2022) Flap endonuclease 1 and DNA-PKcs synergistically participate in stabilizing replication fork to encounter replication stress in glioma cells. J Exp Clin Cancer Res 41(1):140. https:\/\/doi.org\/10.1186\/s13046-022-02334-0","journal-title":"J Exp Clin Cancer Res"},{"key":"5030_CR26","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.freeradbiomed.2019.09.035","volume":"145","author":"M Li","year":"2019","unstructured":"Li M, Gu MM, Lang Y, Shi J, Chen BPC, Guan H, Yu L, Zhou PK, Shang ZF (2019) The vanillin derivative VND3207 protects intestine against radiation injury by modulating p53\/NOXA signaling pathway and restoring the balance of gut microbiota. Free Radic Biol Med 145:223\u2013236. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2019.09.035","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"5030_CR27","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1159\/000502979","volume":"98","author":"M King","year":"2020","unstructured":"King M, Joseph S, Albert A, Thomas TV, Nittala MR, Woods WC, Vijayakumar S, Packianathan S (2020) Use of amifostine for cytoprotection during radiation therapy: a review. Oncology 98(2):61\u201380. https:\/\/doi.org\/10.1159\/000502979","journal-title":"Oncology"},{"key":"5030_CR28","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.10.012","volume":"161","author":"LW Xie","year":"2020","unstructured":"Xie LW, Cai S, Zhao TS, Li M, Tian Y (2020) Green tea derivative (\u2212)-epigallocatechin-3-gallate (EGCG) confers protection against ionizing radiation-induced intestinal epithelial cell death both in vitro and in vivo. Free Radic Biol Med 161:175\u2013186. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2020.10.012","journal-title":"Free Radic Biol Med"},{"key":"5030_CR29","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.bbrc.2021.03.122","volume":"554","author":"H Qin","year":"2021","unstructured":"Qin H, Zhang H, Zhang X, Zhang S, Zhu S, Wang H (2021) Resveratrol attenuates radiation enteritis through the SIRT1\/FOXO3a and PI3K\/AKT signaling pathways. Biochem Biophys Res Commun 554:199\u2013205. https:\/\/doi.org\/10.1016\/j.bbrc.2021.03.122","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"5030_CR30","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/j.molcel.2020.04.035","volume":"78","author":"JM Cleary","year":"2020","unstructured":"Cleary JM, Aguirre AJ, Shapiro GI, D\u2019Andrea AD (2020) Biomarker-guided development of DNA repair inhibitors. Mol Cell 78(6):1070\u20131085. https:\/\/doi.org\/10.1016\/j.molcel.2020.04.035","journal-title":"Mol Cell"},{"key":"5030_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111320","volume":"137","author":"YL Hua","year":"2021","unstructured":"Hua YL, Jia YQ, Zhang XS, Yuan ZW, Ji P, Hu JJ, Wei YM (2021) Baitouweng Tang ameliorates DSS-induced ulcerative colitis through the regulation of the gut microbiota and bile acids via pathways involving FXR and TGR5. Biomed Pharmacother 137:111320. https:\/\/doi.org\/10.1016\/j.biopha.2021.111320","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"5030_CR32","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/s0360-3016(01)02683-9","volume":"52","author":"D Antonadou","year":"2002","unstructured":"Antonadou D, Pepelassi M, Synodinou M, Puglisi M, Throuvalas N (2002) Prophylactic use of amifostine to prevent radiochemotherapy-induced mucositis and xerostomia in head-and-neck cancer. Int J Radiat Oncol Biol Phys 52(3):739\u2013747. https:\/\/doi.org\/10.1016\/s0360-3016(01)02683-9","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"5030_CR33","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1016\/s0360-3016(03)00187-1","volume":"56","author":"H Athanassiou","year":"2003","unstructured":"Athanassiou H, Antonadou D, Coliarakis N, Kouveli A, Synodinou M, Paraskevaidis M, Sarris G, Georgakopoulos GR, Panousaki K, Karageorgis P, Throuvalas N (2003) Protective effect of amifostine during fractionated radiotherapy in patients with pelvic carcinomas: results of a randomized trial. Int J Radiat Oncol Biol Phys 56(4):1154\u20131160. https:\/\/doi.org\/10.1016\/s0360-3016(03)00187-1","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"5","key":"5030_CR34","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/j.immuni.2014.10.019","volume":"41","author":"L Deng","year":"2014","unstructured":"Deng L, Liang H, Xu M, Yang X, Burnette B, Arina A, Li XD, Mauceri H, Beckett M, Darga T, Huang X, Gajewski TF, Chen ZJ, Fu YX, Weichselbaum RR (2014) STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors. Immunity 41(5):843\u2013852. https:\/\/doi.org\/10.1016\/j.immuni.2014.10.019","journal-title":"Immunity"},{"key":"5030_CR35","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12010079","author":"J Kabiljo","year":"2019","unstructured":"Kabiljo J, Harpain F, Carotta S, Bergmann M (2019) Radiotherapy as a backbone for novel concepts in cancer immunotherapy. Cancers (Basel). https:\/\/doi.org\/10.3390\/cancers12010079","journal-title":"Cancers (Basel)"},{"issue":"1","key":"5030_CR36","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1186\/s12906-017-1915-9","volume":"17","author":"H Zhang","year":"2017","unstructured":"Zhang H, Yan H, Zhou X, Wang H, Yang Y, Zhang J, Wang H (2017) The protective effects of resveratrol against radiation-induced intestinal injury. BMC Complement Altern Med 17(1):410. https:\/\/doi.org\/10.1186\/s12906-017-1915-9","journal-title":"BMC Complement Altern Med"},{"issue":"8","key":"5030_CR37","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1038\/bjc.1998.618","volume":"78","author":"CS Potten","year":"1998","unstructured":"Potten CS, Grant HK (1998) The relationship between ionizing radiation-induced apoptosis and stem cells in the small and large intestine. Br J Cancer 78(8):993\u20131003. https:\/\/doi.org\/10.1038\/bjc.1998.618","journal-title":"Br J Cancer"},{"issue":"6","key":"5030_CR38","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1093\/jrr\/rrt077","volume":"54","author":"H Ishihara","year":"2013","unstructured":"Ishihara H, Tanaka I, Yakumaru H, Tanaka M, Yokochi K, Akashi M (2013) Pharmaceutical drugs supporting regeneration of small-intestinal mucosa severely damaged by ionizing radiation in mice. J Radiat Res 54(6):1057\u20131064. https:\/\/doi.org\/10.1093\/jrr\/rrt077","journal-title":"J Radiat Res"},{"issue":"1","key":"5030_CR39","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1159\/000171432","volume":"12","author":"MC Wolvekamp","year":"1994","unstructured":"Wolvekamp MC, de Bruin RW (1994) Diamine oxidase: an overview of historical, biochemical and functional aspects. Dig Dis 12(1):2\u201314. https:\/\/doi.org\/10.1159\/000171432","journal-title":"Dig Dis"},{"issue":"11","key":"5030_CR40","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/s1470-2045(02)00900-2","volume":"3","author":"RR Weichselbaum","year":"2002","unstructured":"Weichselbaum RR, Kufe DW, Hellman S, Rasmussen HS, King CR, Fischer PH, Mauceri HJ (2002) Radiation-induced tumour necrosis factor-alpha expression: clinical application of transcriptional and physical targeting of gene therapy. Lancet Oncol 3(11):665\u2013671. https:\/\/doi.org\/10.1016\/s1470-2045(02)00900-2","journal-title":"Lancet Oncol"},{"key":"5030_CR41","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-022-04094-1","author":"T Wang","year":"2022","unstructured":"Wang T, Wu S, Ibrahim IAA, Fan L (2022) Cardioprotective role of swertiamarin, a plant glycoside against experimentally induced myocardial infarction via antioxidant and anti-inflammatory functions. Appl Biochem Biotechnol. https:\/\/doi.org\/10.1007\/s12010-022-04094-1","journal-title":"Appl Biochem Biotechnol"},{"issue":"1","key":"5030_CR42","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1177\/15353702221131858","volume":"248","author":"H Bernstein","year":"2023","unstructured":"Bernstein H, Bernstein C (2023) Bile acids as carcinogens in the colon and at other sites in the gastrointestinal system. Exp Biol Med (Maywood) 248(1):79\u201389. https:\/\/doi.org\/10.1177\/15353702221131858","journal-title":"Exp Biol Med (Maywood)"},{"issue":"16","key":"5030_CR43","doi-asserted-by":"publisher","first-page":"E1610","DOI":"10.1073\/pnas.1401941111","volume":"111","author":"CM Cremers","year":"2014","unstructured":"Cremers CM, Knoefler D, Vitvitsky V, Banerjee R, Jakob U (2014) Bile salts act as effective protein-unfolding agents and instigators of disulfide stress in vivo. Proc Natl Acad Sci USA 111(16):E1610-1619. https:\/\/doi.org\/10.1073\/pnas.1401941111","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"5030_CR44","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.mrrev.2004.08.001","volume":"589","author":"H Bernstein","year":"2005","unstructured":"Bernstein H, Bernstein C, Payne CM, Dvorakova K, Garewal H (2005) Bile acids as carcinogens in human gastrointestinal cancers. Mutat Res 589(1):47\u201365. https:\/\/doi.org\/10.1016\/j.mrrev.2004.08.001","journal-title":"Mutat Res"},{"key":"5030_CR45","doi-asserted-by":"publisher","DOI":"10.3892\/or.2021.8195","author":"DP Vageli","year":"2021","unstructured":"Vageli DP, Doukas SG, Doukas PG, Judson BL (2021) Bile reflux and hypopharyngeal cancer (Review). Oncol Rep. https:\/\/doi.org\/10.3892\/or.2021.8195","journal-title":"Oncol Rep"},{"issue":"5","key":"5030_CR46","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1093\/carcin\/23.5.839","volume":"23","author":"B Glinghammar","year":"2002","unstructured":"Glinghammar B, Inoue H, Rafter JJ (2002) Deoxycholic acid causes DNA damage in colonic cells with subsequent induction of caspases, COX-2 promoter activity and the transcription factors NF-kB and AP-1. Carcinogenesis 23(5):839\u2013845. https:\/\/doi.org\/10.1093\/carcin\/23.5.839","journal-title":"Carcinogenesis"},{"issue":"3\u20134","key":"5030_CR47","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1080\/01635589109514161","volume":"16","author":"RL Kandell","year":"1991","unstructured":"Kandell RL, Bernstein C (1991) Bile salt\/acid induction of DNA damage in bacterial and mammalian cells: implications for colon cancer. Nutr Cancer 16(3\u20134):227\u2013238. https:\/\/doi.org\/10.1080\/01635589109514161","journal-title":"Nutr Cancer"},{"issue":"9","key":"5030_CR48","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1016\/j.freeradbiomed.2012.01.007","volume":"52","author":"SC Xu","year":"2012","unstructured":"Xu SC, Chen YB, Lin H, Pi HF, Zhang NX, Zhao CC, Shuai L, Zhong M, Yu ZP, Zhou Z, Bie P (2012) Damage to mtDNA in liver injury of patients with extrahepatic cholestasis: the protective effects of mitochondrial transcription factor A. Free Radic Biol Med 52(9):1543\u20131551. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2012.01.007","journal-title":"Free Radic Biol Med"},{"issue":"8 Pt 1","key":"5030_CR49","first-page":"2666","volume":"40","author":"MS Kulkarni","year":"1980","unstructured":"Kulkarni MS, Heidepriem PM, Yielding KL (1980) Production by lithocholic acid of DNA strand breaks in L1210 cells. Cancer Res 40(8 Pt 1):2666\u20132669","journal-title":"Cancer Res"},{"issue":"11","key":"5030_CR50","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1111\/j.1349-7006.1998.tb00510.x","volume":"89","author":"A Ogawa","year":"1998","unstructured":"Ogawa A, Murate T, Suzuki M, Nimura Y, Yoshida S (1998) Lithocholic acid, a putative tumor promoter, inhibits mammalian DNA polymerase beta. Jpn J Cancer Res 89(11):1154\u20131159. https:\/\/doi.org\/10.1111\/j.1349-7006.1998.tb00510.x","journal-title":"Jpn J Cancer Res"},{"issue":"2","key":"5030_CR51","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.ijrobp.2022.08.007","volume":"115","author":"L Guo","year":"2023","unstructured":"Guo L, Da F, Gao Q, Miao X, Guo J, Zhang W, Li J, Wang J, Liu J (2023) Irradiation-induced intestinal injury is associated with disorders of bile acids metabolism. Int J Radiat Oncol Biol Phys 115(2):490\u2013500. https:\/\/doi.org\/10.1016\/j.ijrobp.2022.08.007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"5030_CR52","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s13027-019-0257-2","volume":"14","author":"MJ Gouveia","year":"2019","unstructured":"Gouveia MJ, Brindley PJ, Rinaldi G, G\u00e4rtner F, da Costa JMC, Vale N (2019) Infection with carcinogenic helminth parasites and its production of metabolites induces the formation of DNA-adducts. Infectious Agents & Cancer 14:41. https:\/\/doi.org\/10.1186\/s13027-019-0257-2","journal-title":"Infectious Agents & Cancer"},{"issue":"4","key":"5030_CR53","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1093\/mutage\/geh035","volume":"19","author":"AJ Jolly","year":"2004","unstructured":"Jolly AJ, Wild CP, Hardie LJ (2004) Acid and bile salts induce DNA damage in human oesophageal cell lines. Mutagenesis 19(4):319\u2013324. https:\/\/doi.org\/10.1093\/mutage\/geh035","journal-title":"Mutagenesis"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-024-05030-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-024-05030-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-024-05030-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T14:47:36Z","timestamp":1743691656000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-024-05030-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,25]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["5030"],"URL":"https:\/\/doi.org\/10.1007\/s11010-024-05030-z","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,25]]},"assertion":[{"value":"27 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have not disclosed any competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}