{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T21:50:42Z","timestamp":1793829042394,"version":"4.6.1"},"reference-count":133,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32100918"],"award-info":[{"award-number":["32100918"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31971096"],"award-info":[{"award-number":["31971096"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32300959"],"award-info":[{"award-number":["32300959"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2021M690060"],"award-info":[{"award-number":["2021M690060"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Guangzhou Scientific Research Grant","award":["L2024A04J00578"],"award-info":[{"award-number":["L2024A04J00578"]}]},{"name":"SCNU Young Faculty Development Program","award":["22KJ04"],"award-info":[{"award-number":["22KJ04"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s11010-024-05071-4","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T08:02:22Z","timestamp":1722499342000},"page":"1983-1998","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["The role of estrogen in Alzheimer\u2019s disease pathogenesis and therapeutic potential in women"],"prefix":"10.1007","volume":"480","author":[{"given":"Xinyi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianting","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongyun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luodan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,1]]},"reference":[{"issue":"1","key":"5071_CR1","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.yfrne.2013.08.001","volume":"35","author":"JR Rettberg","year":"2014","unstructured":"Rettberg JR, Yao J, Brinton RD (2014) Estrogen: a master regulator of bioenergetic systems in the brain and body. Front Neuroendocrinol 35(1):8\u201330. https:\/\/doi.org\/10.1016\/j.yfrne.2013.08.001","journal-title":"Front Neuroendocrinol"},{"key":"5071_CR2","doi-asserted-by":"publisher","first-page":"1220150","DOI":"10.3389\/fendo.2023.1220150","volume":"14","author":"K Sato","year":"2023","unstructured":"Sato K, Takayama KI, Inoue S (2023) Expression and function of estrogen receptors and estrogen-related receptors in the brain and their association with Alzheimer\u2019s disease. Front Endocrinol (Lausanne) 14:1220150. https:\/\/doi.org\/10.3389\/fendo.2023.1220150","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"4","key":"5071_CR3","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1007\/s12640-020-00289-8","volume":"38","author":"A Wnuk","year":"2020","unstructured":"Wnuk A, Przepiorska K, Rzemieniec J, Pietrzak B, Kajta M (2020) Selective targeting of non-nuclear estrogen receptors with PaPE-1 as a New treatment strategy for Alzheimer\u2019s disease. Neurotox Res 38(4):957\u2013966. https:\/\/doi.org\/10.1007\/s12640-020-00289-8","journal-title":"Neurotox Res"},{"issue":"6","key":"5071_CR4","doi-asserted-by":"publisher","first-page":"2654","DOI":"10.1007\/s12035-020-01911-8","volume":"57","author":"MS Uddin","year":"2020","unstructured":"Uddin MS, Rahman MM, Jakaria M, Rahman MS, Hossain MS, Islam A et al (2020) Estrogen signaling in Alzheimer\u2019s disease: molecular insights and therapeutic targets for Alzheimer\u2019s dementia. Mol Neurobiol 57(6):2654\u20132670. https:\/\/doi.org\/10.1007\/s12035-020-01911-8","journal-title":"Mol Neurobiol"},{"key":"5071_CR5","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/B978-0-12-804766-8.00013-3","volume":"167","author":"JA Soria Lopez","year":"2019","unstructured":"Soria Lopez JA, Gonzalez HM, Leger GC (2019) Alzheimer\u2019s disease. Handb Clin Neurol 167:231\u2013255. https:\/\/doi.org\/10.1016\/B978-0-12-804766-8.00013-3","journal-title":"Handb Clin Neurol"},{"key":"5071_CR6","doi-asserted-by":"publisher","unstructured":"Weller J, Budson A (2018) Current understanding of Alzheimer\u2019s disease diagnosis and treatment. F1000Research. https:\/\/doi.org\/10.12688\/f1000research.14506.1","DOI":"10.12688\/f1000research.14506.1"},{"issue":"1\u20132","key":"5071_CR7","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1002\/jnr.23827","volume":"95","author":"CJ Pike","year":"2017","unstructured":"Pike CJ (2017) Sex and the development of Alzheimer\u2019s disease. J Neurosci Res 95(1\u20132):671\u2013680. https:\/\/doi.org\/10.1002\/jnr.23827","journal-title":"J Neurosci Res"},{"issue":"1","key":"5071_CR8","doi-asserted-by":"publisher","first-page":"E164","DOI":"10.1152\/ajpendo.00008.2021","volume":"321","author":"A Bagit","year":"2021","unstructured":"Bagit A, Hayward GC, MacPherson REK (2021) Exercise and estrogen: common pathways in Alzheimer\u2019s disease pathology. Am J Physiol Endocrinol Metab 321(1):E164\u2013E168. https:\/\/doi.org\/10.1152\/ajpendo.00008.2021","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"2","key":"5071_CR9","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.cell.2019.09.001","volume":"179","author":"JM Long","year":"2019","unstructured":"Long JM, Holtzman DM (2019) Alzheimer disease: an update on pathobiology and treatment strategies. Cell 179(2):312\u2013339. https:\/\/doi.org\/10.1016\/j.cell.2019.09.001","journal-title":"Cell"},{"issue":"10","key":"5071_CR10","doi-asserted-by":"publisher","first-page":"3434","DOI":"10.7150\/thno.81951","volume":"13","author":"S Feng","year":"2023","unstructured":"Feng S, Wu C, Zou P, Deng Q, Chen Z, Li M et al (2023) High-intensity interval training ameliorates Alzheimer\u2019s disease-like pathology by regulating astrocyte phenotype-associated AQP4 polarization. Theranostics 13(10):3434\u20133450. https:\/\/doi.org\/10.7150\/thno.81951","journal-title":"Theranostics"},{"key":"5071_CR11","doi-asserted-by":"publisher","first-page":"572308","DOI":"10.3389\/fnmol.2020.572308","volume":"13","author":"K Zubcic","year":"2020","unstructured":"Zubcic K, Hof PR, Simic G, Jazvinscak Jembrek M (2020) The role of copper in tau-related pathology in Alzheimer\u2019s disease. Front Mol Neurosci 13:572308. https:\/\/doi.org\/10.3389\/fnmol.2020.572308","journal-title":"Front Mol Neurosci"},{"key":"5071_CR12","doi-asserted-by":"publisher","first-page":"1021796","DOI":"10.3389\/fendo.2022.1021796","volume":"13","author":"P Villaseca","year":"2022","unstructured":"Villaseca P, Cisternas P, Inestrosa NC (2022) Menopause and development of Alzheimer\u2019s disease: roles of neural glucose metabolism and wnt signaling. Front Endocrinol (Lausanne) 13:1021796. https:\/\/doi.org\/10.3389\/fendo.2022.1021796","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"5071_CR13","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/2047-9158-3-6","volume":"3","author":"ER Zimmer","year":"2014","unstructured":"Zimmer ER, Leuzy A, Bhat V, Gauthier S, Rosa-Neto P (2014) In vivo tracking of tau pathology using positron emission tomography (PET) molecular imaging in small animals. Transl Neurodegener 3(1):6. https:\/\/doi.org\/10.1186\/2047-9158-3-6","journal-title":"Transl Neurodegener"},{"issue":"1","key":"5071_CR14","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s41232-022-00216-8","volume":"42","author":"C Wu","year":"2022","unstructured":"Wu C, Yang L, Feng S, Zhu L, Yang L, Liu TC et al (2022) Therapeutic non-invasive brain treatments in Alzheimer\u2019s disease: recent advances and challenges. Inflamm Regen 42(1):31. https:\/\/doi.org\/10.1186\/s41232-022-00216-8","journal-title":"Inflamm Regen"},{"issue":"18","key":"5071_CR15","doi-asserted-by":"publisher","first-page":"6972","DOI":"10.1523\/JNEUROSCI.23-18-06972.2003","volume":"23","author":"T Arendt","year":"2003","unstructured":"Arendt T, Stieler J, Strijkstra AM, Hut RA, Rudiger J, Van der Zee EA et al (2003) Reversible paired helical filament-like phosphorylation of tau is an adaptive process associated with neuronal plasticity in hibernating animals. J Neurosci 23(18):6972\u20136981. https:\/\/doi.org\/10.1523\/JNEUROSCI.23-18-06972.2003","journal-title":"J Neurosci"},{"issue":"5","key":"5071_CR16","doi-asserted-by":"publisher","first-page":"307","DOI":"10.3109\/00207454.2013.833510","volume":"124","author":"Z Cai","year":"2014","unstructured":"Cai Z, Hussain MD, Yan LJ (2014) Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer\u2019s disease. Int J Neurosci 124(5):307\u2013321. https:\/\/doi.org\/10.3109\/00207454.2013.833510","journal-title":"Int J Neurosci"},{"issue":"10","key":"5071_CR17","doi-asserted-by":"publisher","first-page":"4274","DOI":"10.1038\/s41380-022-01686-5","volume":"27","author":"S Ziegler-Waldkirch","year":"2022","unstructured":"Ziegler-Waldkirch S, Friesen M, Loreth D, Sauer JF, Kemna S, Hilse A et al (2022) Seed-induced abeta deposition alters neuronal function and impairs olfaction in a mouse model of Alzheimer\u2019s disease. Mol Psychiatry 27(10):4274\u20134284. https:\/\/doi.org\/10.1038\/s41380-022-01686-5","journal-title":"Mol Psychiatry"},{"issue":"1","key":"5071_CR18","doi-asserted-by":"publisher","first-page":"e53117","DOI":"10.1371\/journal.pone.0053117","volume":"8","author":"C Zussy","year":"2013","unstructured":"Zussy C, Brureau A, Keller E, Marchal S, Blayo C, Delair B et al (2013) Alzheimer\u2019s disease related markers, cellular toxicity and behavioral deficits induced six weeks after oligomeric amyloid-beta peptide injection in rats. PLoS ONE 8(1):e53117. https:\/\/doi.org\/10.1371\/journal.pone.0053117","journal-title":"PLoS ONE"},{"key":"5071_CR19","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.neuropharm.2015.05.007","volume":"106","author":"A Zlomuzica","year":"2016","unstructured":"Zlomuzica A, Dere D, Binder S, De Souza Silva MA, Huston JP, Dere E (2016) Neuronal histamine and cognitive symptoms in Alzheimer\u2019s disease. Neuropharmacology 106:135\u2013145. https:\/\/doi.org\/10.1016\/j.neuropharm.2015.05.007","journal-title":"Neuropharmacology"},{"issue":"3","key":"5071_CR20","doi-asserted-by":"publisher","first-page":"329","DOI":"10.11613\/BM.2014.035","volume":"24","author":"P Vrtacnik","year":"2014","unstructured":"Vrtacnik P, Ostanek B, Mencej-Bedrac S, Marc J (2014) The many faces of estrogen signaling. Biochem Med (Zagreb) 24(3):329\u2013342. https:\/\/doi.org\/10.11613\/BM.2014.035","journal-title":"Biochem Med (Zagreb)"},{"issue":"3","key":"5071_CR21","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1007\/s13311-019-00766-9","volume":"16","author":"JK Russell","year":"2019","unstructured":"Russell JK, Jones CK, Newhouse PA (2019) The role of estrogen in brain and cognitive aging. Neurotherapeutics 16(3):649\u2013665. https:\/\/doi.org\/10.1007\/s13311-019-00766-9","journal-title":"Neurotherapeutics"},{"issue":"3","key":"5071_CR22","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1007\/s11011-023-01161-2","volume":"38","author":"AC Tecalco-Cruz","year":"2023","unstructured":"Tecalco-Cruz AC, Lopez-Canovas L, Azuara-Liceaga E (2023) Estrogen signaling via estrogen receptor alpha and its implications for neurodegeneration associated with Alzheimer\u2019s disease in aging women. Metab Brain Dis 38(3):783\u2013793. https:\/\/doi.org\/10.1007\/s11011-023-01161-2","journal-title":"Metab Brain Dis"},{"issue":"1","key":"5071_CR23","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s40360-022-00574-6","volume":"23","author":"Z Hao","year":"2022","unstructured":"Hao Z, Xu J, Zhao H, Zhou W, Liu Z, He S et al (2022) The inhibition of tamoxifen on UGT2B gene expression and enzyme activity in rat liver contribute to the estrogen homeostasis dysregulation. BMC Pharmacol Toxicol 23(1):33. https:\/\/doi.org\/10.1186\/s40360-022-00574-6","journal-title":"BMC Pharmacol Toxicol"},{"key":"5071_CR24","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23168946","author":"D Kata","year":"2022","unstructured":"Kata D, Grof I, Hoyk Z, Ducza E, Deli MA, Zupko I et al (2022) Immunofluorescent evidence for nuclear localization of aromatase in astrocytes in the rat central nervous system. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms23168946","journal-title":"Int J Mol Sci"},{"issue":"7","key":"5071_CR25","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.tins.2015.05.004","volume":"38","author":"CA Cornil","year":"2015","unstructured":"Cornil CA, Ball GF, Balthazart J (2015) The dual action of estrogen hypothesis. Trends Neurosci 38(7):408\u2013416. https:\/\/doi.org\/10.1016\/j.tins.2015.05.004","journal-title":"Trends Neurosci"},{"issue":"4","key":"5071_CR26","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.yfrne.2012.08.001","volume":"33","author":"E Terasawa","year":"2012","unstructured":"Terasawa E, Kenealy BP (2012) Neuroestrogen, rapid action of estradiol, and GnRH neurons. Front Neuroendocrinol 33(4):364\u2013375. https:\/\/doi.org\/10.1016\/j.yfrne.2012.08.001","journal-title":"Front Neuroendocrinol"},{"issue":"6","key":"5071_CR27","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1093\/humupd\/dmn033","volume":"14","author":"A Requena","year":"2008","unstructured":"Requena A, Herrero J, Landeras J, Navarro E, Neyro JL, Salvador C et al (2008) Use of letrozole in assisted reproduction: a systematic review and meta-analysis. Hum Reprod Update 14(6):571\u2013582. https:\/\/doi.org\/10.1093\/humupd\/dmn033","journal-title":"Hum Reprod Update"},{"key":"5071_CR28","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.yfrne.2014.08.001","volume":"36","author":"K Sellers","year":"2015","unstructured":"Sellers K, Raval P, Srivastava DP (2015) Molecular signature of rapid estrogen regulation of synaptic connectivity and cognition. Front Neuroendocrinol 36:72\u201389. https:\/\/doi.org\/10.1016\/j.yfrne.2014.08.001","journal-title":"Front Neuroendocrinol"},{"key":"5071_CR29","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1146\/annurev.pharmtox.47.120505.105219","volume":"47","author":"CS Woolley","year":"2007","unstructured":"Woolley CS (2007) Acute effects of estrogen on neuronal physiology. Annu Rev Pharmacol Toxicol 47:657\u2013680. https:\/\/doi.org\/10.1146\/annurev.pharmtox.47.120505.105219","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"5071_CR30","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/j.neubiorev.2021.11.014","volume":"132","author":"DW Brann","year":"2022","unstructured":"Brann DW, Lu Y, Wang J, Zhang Q, Thakkar R, Sareddy GR et al (2022) Brain-derived estrogen and neural function. Neurosci Biobehav Rev 132:793\u2013817. https:\/\/doi.org\/10.1016\/j.neubiorev.2021.11.014","journal-title":"Neurosci Biobehav Rev"},{"key":"5071_CR31","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.steroids.2016.06.007","volume":"114","author":"E Kulkoyluoglu","year":"2016","unstructured":"Kulkoyluoglu E, Madak-Erdogan Z (2016) Nuclear and extranuclear-initiated estrogen receptor signaling crosstalk and endocrine resistance in breast cancer. Steroids 114:41\u201347. https:\/\/doi.org\/10.1016\/j.steroids.2016.06.007","journal-title":"Steroids"},{"issue":"1","key":"5071_CR32","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1037\/a0026708","volume":"126","author":"BS McEwen","year":"2012","unstructured":"McEwen BS, Akama KT, Spencer-Segal JL, Milner TA, Waters EM (2012) Estrogen effects on the brain: actions beyond the hypothalamus via novel mechanisms. Behav Neurosci 126(1):4\u201316. https:\/\/doi.org\/10.1037\/a0026708","journal-title":"Behav Neurosci"},{"key":"5071_CR33","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12121995","author":"Z Yu","year":"2022","unstructured":"Yu Z, Jiao Y, Zhao Y, Gu W (2022) Level of estrogen in females-the different impacts at different life stages. J Pers Med. https:\/\/doi.org\/10.3390\/jpm12121995","journal-title":"J Pers Med"},{"issue":"1","key":"5071_CR34","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/s0753-3322(01)00155-x","volume":"56","author":"H Tapiero","year":"2002","unstructured":"Tapiero H, Ba GN, Tew KD (2002) Estrogens and environmental estrogens. Biomed Pharmacother 56(1):36\u201344. https:\/\/doi.org\/10.1016\/s0753-3322(01)00155-x","journal-title":"Biomed Pharmacother"},{"key":"5071_CR35","doi-asserted-by":"publisher","first-page":"839005","DOI":"10.3389\/fendo.2022.839005","volume":"13","author":"P Chen","year":"2022","unstructured":"Chen P, Li B, Ou-Yang L (2022) Role of estrogen receptors in health and disease. Front Endocrinol (Lausanne) 13:839005. https:\/\/doi.org\/10.3389\/fendo.2022.839005","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"9","key":"5071_CR36","doi-asserted-by":"publisher","first-page":"4111","DOI":"10.1210\/en.2012-1435","volume":"153","author":"WA Banks","year":"2012","unstructured":"Banks WA (2012) Brain meets body: the blood\u2013brain barrier as an endocrine interface. Endocrinology 153(9):4111\u20134119. https:\/\/doi.org\/10.1210\/en.2012-1435","journal-title":"Endocrinology"},{"issue":"6","key":"5071_CR37","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1042\/EBC20200162","volume":"65","author":"S Maioli","year":"2021","unstructured":"Maioli S, Leander K, Nilsson P, Nalvarte I (2021) Estrogen receptors and the aging brain. Essays Biochem 65(6):913\u2013925. https:\/\/doi.org\/10.1042\/EBC20200162","journal-title":"Essays Biochem"},{"issue":"4","key":"5071_CR38","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1210\/me.2004-0486","volume":"19","author":"L Bjornstrom","year":"2005","unstructured":"Bjornstrom L, Sjoberg M (2005) Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes. Mol Endocrinol 19(4):833\u2013842. https:\/\/doi.org\/10.1210\/me.2004-0486","journal-title":"Mol Endocrinol"},{"issue":"1\u20132","key":"5071_CR39","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/s0303-7207(03)00255-7","volume":"206","author":"WR Harrington","year":"2003","unstructured":"Harrington WR, Sheng S, Barnett DH, Petz LN, Katzenellenbogen JA, Katzenellenbogen BS (2003) Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression. Mol Cell Endocrinol 206(1\u20132):13\u201322. https:\/\/doi.org\/10.1016\/s0303-7207(03)00255-7","journal-title":"Mol Cell Endocrinol"},{"key":"5071_CR40","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.steroids.2014.06.012","volume":"90","author":"I Paterni","year":"2014","unstructured":"Paterni I, Granchi C, Katzenellenbogen JA, Minutolo F (2014) Estrogen receptors alpha (ERalpha) and beta (ERbeta): subtype-selective ligands and clinical potential. Steroids 90:13\u201329. https:\/\/doi.org\/10.1016\/j.steroids.2014.06.012","journal-title":"Steroids"},{"issue":"4","key":"5071_CR41","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1002\/hipo.20935","volume":"22","author":"TC Foster","year":"2012","unstructured":"Foster TC (2012) Role of estrogen receptor alpha and beta expression and signaling on cognitive function during aging. Hippocampus 22(4):656\u2013669. https:\/\/doi.org\/10.1002\/hipo.20935","journal-title":"Hippocampus"},{"issue":"3","key":"5071_CR42","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1017\/neu.2013.48","volume":"26","author":"DD Leffa","year":"2014","unstructured":"Leffa DD, Damiani AP, Damazio DD, Guerra NP, Moretti M, de Brito GG et al (2014) Long-term effects of ageing and ovariectomy on aversive and recognition memory and DNA damage in the hippocampus of female rats. Acta Neuropsychiatr 26(3):161\u2013169. https:\/\/doi.org\/10.1017\/neu.2013.48","journal-title":"Acta Neuropsychiatr"},{"issue":"2","key":"5071_CR43","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1002\/mrd.1120210208","volume":"21","author":"S Speirs","year":"1988","unstructured":"Speirs S, Kaufman MH (1988) Effect of exogenous hormones on the ovulation of primary and secondary oocytes in LT\/Sv strain mice. Gamete Res 21(2):179\u2013184. https:\/\/doi.org\/10.1002\/mrd.1120210208","journal-title":"Gamete Res"},{"key":"5071_CR44","doi-asserted-by":"publisher","first-page":"636176","DOI":"10.3389\/fncel.2021.636176","volume":"15","author":"FA Bustamante-Barrientos","year":"2021","unstructured":"Bustamante-Barrientos FA, Mendez-Ruette M, Ortloff A, Luz-Crawford P, Rivera FJ, Figueroa CD et al (2021) The impact of estrogen and estrogen-like molecules in neurogenesis and neurodegeneration: beneficial or harmful? Front Cell Neurosci 15:636176. https:\/\/doi.org\/10.3389\/fncel.2021.636176","journal-title":"Front Cell Neurosci"},{"issue":"4","key":"5071_CR45","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1210\/er.2016-1007","volume":"37","author":"A Villa","year":"2016","unstructured":"Villa A, Vegeto E, Poletti A, Maggi A (2016) Estrogens, neuroinflammation, and neurodegeneration. Endocr Rev 37(4):372\u2013402. https:\/\/doi.org\/10.1210\/er.2016-1007","journal-title":"Endocr Rev"},{"issue":"6","key":"5071_CR46","doi-asserted-by":"publisher","first-page":"405","DOI":"10.2165\/00002512-200219060-00002","volume":"19","author":"B Cholerton","year":"2002","unstructured":"Cholerton B, Gleason CE, Baker LD, Asthana S (2002) Estrogen and Alzheimer\u2019s disease: the story so far. Drugs Aging 19(6):405\u2013427. https:\/\/doi.org\/10.2165\/00002512-200219060-00002","journal-title":"Drugs Aging"},{"key":"5071_CR47","doi-asserted-by":"publisher","first-page":"133","DOI":"10.3389\/fendo.2018.00133","volume":"9","author":"D Munoz-Mayorga","year":"2018","unstructured":"Munoz-Mayorga D, Guerra-Araiza C, Torner L, Morales T (2018) Tau phosphorylation in female neurodegeneration: role of estrogens, progesterone, and prolactin. Front Endocrinol (Lausanne) 9:133. https:\/\/doi.org\/10.3389\/fendo.2018.00133","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"5","key":"5071_CR48","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.steroids.2007.02.003","volume":"72","author":"DW Brann","year":"2007","unstructured":"Brann DW, Dhandapani K, Wakade C, Mahesh VB, Khan MM (2007) Neurotrophic and neuroprotective actions of estrogen: basic mechanisms and clinical implications. Steroids 72(5):381\u2013405. https:\/\/doi.org\/10.1016\/j.steroids.2007.02.003","journal-title":"Steroids"},{"issue":"4","key":"5071_CR49","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1038\/nm0498-447","volume":"4","author":"H Xu","year":"1998","unstructured":"Xu H, Gouras GK, Greenfield JP, Vincent B, Naslund J, Mazzarelli L et al (1998) Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. Nat Med 4(4):447\u2013451. https:\/\/doi.org\/10.1038\/nm0498-447","journal-title":"Nat Med"},{"issue":"12","key":"5071_CR50","doi-asserted-by":"publisher","first-page":"6198","DOI":"10.1210\/en.2008-0122","volume":"149","author":"J Weiss","year":"2008","unstructured":"Weiss J, Bernhardt ML, Laronda MM, Hurley LA, Glidewell-Kenney C, Pillai S et al (2008) Estrogen actions in the male reproductive system involve estrogen response element-independent pathways. Endocrinology 149(12):6198\u20136206. https:\/\/doi.org\/10.1210\/en.2008-0122","journal-title":"Endocrinology"},{"issue":"4","key":"5071_CR51","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1095\/biolreprod.111.091611","volume":"85","author":"W Zhou","year":"2011","unstructured":"Zhou W, Bolden-Tiller OU, Shao SH, Weng CC, Shetty G, AbuElhija M et al (2011) Estrogen-regulated genes in rat testes and their relationship to recovery of spermatogenesis after irradiation. Biol Reprod 85(4):823\u2013833. https:\/\/doi.org\/10.1095\/biolreprod.111.091611","journal-title":"Biol Reprod"},{"issue":"2","key":"5071_CR52","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.cellimm.2015.01.018","volume":"294","author":"S Kovats","year":"2015","unstructured":"Kovats S (2015) Estrogen receptors regulate innate immune cells and signaling pathways. Cell Immunol 294(2):63\u201369. https:\/\/doi.org\/10.1016\/j.cellimm.2015.01.018","journal-title":"Cell Immunol"},{"issue":"1546","key":"5071_CR53","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1098\/rstb.2009.0113","volume":"365","author":"S Carreau","year":"2010","unstructured":"Carreau S, Wolczynski S, Galeraud-Denis I (2010) Aromatase, oestrogens and human male reproduction. Philos Trans R Soc Lond B Biol Sci 365(1546):1571\u20131579. https:\/\/doi.org\/10.1098\/rstb.2009.0113","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"3","key":"5071_CR54","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1210\/edrv.22.3.0431","volume":"22","author":"L O\u2019Donnell","year":"2001","unstructured":"O\u2019Donnell L, Robertson KM, Jones ME, Simpson ER (2001) Estrogen and spermatogenesis. Endocr Rev 22(3):289\u2013318. https:\/\/doi.org\/10.1210\/edrv.22.3.0431","journal-title":"Endocr Rev"},{"issue":"1","key":"5071_CR55","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/biolre\/ioy043","volume":"99","author":"RA Hess","year":"2018","unstructured":"Hess RA, Cooke PS (2018) Estrogen in the male: a historical perspective. Biol Reprod 99(1):27\u201344. https:\/\/doi.org\/10.1093\/biolre\/ioy043","journal-title":"Biol Reprod"},{"key":"5071_CR56","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.diff.2020.11.002","volume":"118","author":"PS Cooke","year":"2021","unstructured":"Cooke PS, Mesa AM, Sirohi VK, Levin ER (2021) Role of nuclear and membrane estrogen signaling pathways in the male and female reproductive tract. Differentiation 118:24\u201333. https:\/\/doi.org\/10.1016\/j.diff.2020.11.002","journal-title":"Differentiation"},{"issue":"9","key":"5071_CR57","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/s0039-128x(99)00041-0","volume":"64","author":"TO Abney","year":"1999","unstructured":"Abney TO (1999) The potential roles of estrogens in regulating Leydig cell development and function: a review. Steroids 64(9):610\u2013617. https:\/\/doi.org\/10.1016\/s0039-128x(99)00041-0","journal-title":"Steroids"},{"issue":"1","key":"5071_CR58","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1093\/toxsci\/kfy077","volume":"164","author":"S Zhou","year":"2018","unstructured":"Zhou S, Wang Y, Ma L, Chen X, Lu Y, Ge F et al (2018) Zearalenone delays rat leydig cell regeneration. Toxicol Sci 164(1):60\u201371. https:\/\/doi.org\/10.1093\/toxsci\/kfy077","journal-title":"Toxicol Sci"},{"key":"5071_CR59","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.semcdb.2016.03.003","volume":"59","author":"Q Wen","year":"2016","unstructured":"Wen Q, Cheng CY, Liu YX (2016) Development, function and fate of fetal leydig cells. Semin Cell Dev Biol 59:89\u201398. https:\/\/doi.org\/10.1016\/j.semcdb.2016.03.003","journal-title":"Semin Cell Dev Biol"},{"issue":"2\u20133","key":"5071_CR60","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/s0304-4165(96)00115-8","volume":"1334","author":"IH Zwain","year":"1997","unstructured":"Zwain IH, Yen SS, Cheng CY (1997) Astrocytes cultured in vitro produce estradiol-17beta and express aromatase cytochrome P-450 (P-450 AROM) mRNA. Biochim Biophys Acta 1334(2\u20133):338\u2013348. https:\/\/doi.org\/10.1016\/s0304-4165(96)00115-8","journal-title":"Biochim Biophys Acta"},{"key":"5071_CR61","doi-asserted-by":"publisher","DOI":"10.3390\/biology11121698","author":"DW Brann","year":"2022","unstructured":"Brann DW, Lu Y, Wang J, Sareddy GR, Pratap UP, Zhang Q et al (2022) Brain-derived estrogen and neurological disorders. Biology (Basel). https:\/\/doi.org\/10.3390\/biology11121698","journal-title":"Biology (Basel)"},{"key":"5071_CR62","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105360","author":"Y Lu","year":"2022","unstructured":"Lu Y, Wang J, Tang F, Pratap UP, Sareddy GR, Dhandapani KM et al (2022) Regulation and role of neuron-derived hemoglobin in the mouse hippocampus. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms23105360","journal-title":"Int J Mol Sci"},{"key":"5071_CR63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.steroids.2018.04.001","volume":"134","author":"M Verderame","year":"2018","unstructured":"Verderame M, Scudiero R (2018) A comparative review on estrogen receptors in the reproductive male tract of non mammalian vertebrates. Steroids 134:1\u20138. https:\/\/doi.org\/10.1016\/j.steroids.2018.04.001","journal-title":"Steroids"},{"issue":"9","key":"5071_CR64","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/s1043-2760(98)00089-7","volume":"9","author":"RM Sharpe","year":"1998","unstructured":"Sharpe RM (1998) The roles of oestrogen in the male. Trends Endocrinol Metab 9(9):371\u2013377. https:\/\/doi.org\/10.1016\/s1043-2760(98)00089-7","journal-title":"Trends Endocrinol Metab"},{"key":"5071_CR65","doi-asserted-by":"publisher","DOI":"10.3390\/cells8101123","author":"ZR Tang","year":"2019","unstructured":"Tang ZR, Zhang R, Lian ZX, Deng SL, Yu K (2019) Estrogen-receptor expression and function in female reproductive disease. Cells. https:\/\/doi.org\/10.3390\/cells8101123","journal-title":"Cells"},{"issue":"3","key":"5071_CR66","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.molmed.2012.12.007","volume":"19","author":"J Cui","year":"2013","unstructured":"Cui J, Shen Y, Li R (2013) Estrogen synthesis and signaling pathways during aging: from periphery to brain. Trends Mol Med 19(3):197\u2013209. https:\/\/doi.org\/10.1016\/j.molmed.2012.12.007","journal-title":"Trends Mol Med"},{"key":"5071_CR67","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.brainres.2010.10.031","volume":"1379","author":"WA Rocca","year":"2011","unstructured":"Rocca WA, Grossardt BR, Shuster LT (2011) Oophorectomy, menopause, estrogen treatment, and cognitive aging: clinical evidence for a window of opportunity. Brain Res 1379:188\u2013198. https:\/\/doi.org\/10.1016\/j.brainres.2010.10.031","journal-title":"Brain Res"},{"key":"5071_CR68","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.bpobgyn.2021.10.009","volume":"81","author":"E Hogervorst","year":"2022","unstructured":"Hogervorst E, Craig J, O\u2019Donnell E (2022) Cognition and mental health in menopause: a review. Best Pract Res Clin Obstet Gynaecol 81:69\u201384. https:\/\/doi.org\/10.1016\/j.bpobgyn.2021.10.009","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"5071_CR69","doi-asserted-by":"publisher","first-page":"2628","DOI":"10.1038\/ncomms3628","volume":"4","author":"Y Rui","year":"2013","unstructured":"Rui Y, Myers KR, Yu K, Wise A, De Blas AL, Hartzell HC et al (2013) Activity-dependent regulation of dendritic growth and maintenance by glycogen synthase kinase 3beta. Nat Commun 4:2628. https:\/\/doi.org\/10.1038\/ncomms3628","journal-title":"Nat Commun"},{"key":"5071_CR70","doi-asserted-by":"publisher","first-page":"8101615","DOI":"10.1155\/2021\/8101615","volume":"2021","author":"C Borras","year":"2021","unstructured":"Borras C, Ferrando M, Ingles M, Gambini J, Lopez-Grueso R, Edo R et al (2021) Estrogen replacement therapy induces antioxidant and longevity-related genes in women after medically induced menopause. Oxid Med Cell Longev 2021:8101615. https:\/\/doi.org\/10.1155\/2021\/8101615","journal-title":"Oxid Med Cell Longev"},{"key":"5071_CR71","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8860467","author":"F Zovari","year":"2020","unstructured":"Zovari F, Parsian H, Bijani A, Moslemnezhad A, Shirzad A (2020) Evaluation of salivary and serum total antioxidant capacity and lipid peroxidation in postmenopausal women. Int J Dent. https:\/\/doi.org\/10.1155\/2020\/8860467. 2020(8860467","journal-title":"Int J Dent"},{"issue":"1","key":"5071_CR72","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/1423-0127-19-76","volume":"19","author":"KL Wu","year":"2012","unstructured":"Wu KL, Chen CH, Shih CD (2012) Nontranscriptional activation of PI3K\/Akt signaling mediates hypotensive effect following activation of estrogen receptor beta in the rostral ventrolateral medulla of rats. J Biomed Sci 19(1):76. https:\/\/doi.org\/10.1186\/1423-0127-19-76","journal-title":"J Biomed Sci"},{"issue":"1\u20132","key":"5071_CR73","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.mce.2005.11.007","volume":"246","author":"R Yashwanth","year":"2006","unstructured":"Yashwanth R, Rama S, Anbalagan M, Rao AJ (2006) Role of estrogen in regulation of cellular differentiation: a study using human placental and rat leydig cells. Mol Cell Endocrinol 246(1\u20132):114\u2013120. https:\/\/doi.org\/10.1016\/j.mce.2005.11.007","journal-title":"Mol Cell Endocrinol"},{"issue":"4","key":"5071_CR74","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/s1550-8579(06)80214-7","volume":"3","author":"SM Harman","year":"2006","unstructured":"Harman SM (2006) Estrogen replacement in menopausal women: recent and current prospective studies, the WHI and the KEEPS. Gend Med 3(4):254\u2013269. https:\/\/doi.org\/10.1016\/s1550-8579(06)80214-7","journal-title":"Gend Med"},{"key":"5071_CR75","doi-asserted-by":"publisher","DOI":"10.3390\/nu13103334","author":"Q Zuo","year":"2021","unstructured":"Zuo Q, Chen KL, Arredondo Eve A, Liu YJ, Kim SH, Katzenellenbogen BS et al (2021) Pathway preferential estrogens prevent hepatosteatosis due to ovariectomy and high-fat diets. Nutrients. https:\/\/doi.org\/10.3390\/nu13103334","journal-title":"Nutrients"},{"key":"5071_CR76","doi-asserted-by":"publisher","first-page":"204201882110139","DOI":"10.1177\/20420188211013917","volume":"12","author":"S Prabakaran","year":"2021","unstructured":"Prabakaran S, Schwartz A, Lundberg G (2021) Cardiovascular risk in menopausal women and our evolving understanding of menopausal hormone therapy: risks, benefits, and current guidelines for use. Ther Adv Endocrinol Metab 12:20420188211013917. https:\/\/doi.org\/10.1177\/20420188211013917","journal-title":"Ther Adv Endocrinol Metab"},{"issue":"8","key":"5071_CR77","doi-asserted-by":"publisher","first-page":"3443","DOI":"10.1210\/en.2009-0449","volume":"150","author":"J Iqbal","year":"2009","unstructured":"Iqbal J, Zaidi M (2009) Understanding estrogen action during menopause. Endocrinology 150(8):3443\u20133445. https:\/\/doi.org\/10.1210\/en.2009-0449","journal-title":"Endocrinology"},{"issue":"4","key":"5071_CR78","doi-asserted-by":"publisher","first-page":"225","DOI":"10.14283\/jpad.2018.34","volume":"5","author":"O Scheyer","year":"2018","unstructured":"Scheyer O, Rahman A, Hristov H, Berkowitz C, Isaacson RS, Diaz Brinton R et al (2018) Female sex and Alzheimer\u2019s risk: the menopause connection. J Prev Alzheimers Dis 5(4):225\u2013230. https:\/\/doi.org\/10.14283\/jpad.2018.34","journal-title":"J Prev Alzheimers Dis"},{"issue":"3","key":"5071_CR79","doi-asserted-by":"publisher","first-page":"138","DOI":"10.5114\/pm.2016.62660","volume":"15","author":"D Zolnierczuk-Kieliszek","year":"2016","unstructured":"Zolnierczuk-Kieliszek D, Janiszewska M, Mielniczuk A, Dziedzic MA, Firlej E (2016) Professional activity of Polish peri- and postmenopausal women. Prz Menopauzalny 15(3):138\u2013142. https:\/\/doi.org\/10.5114\/pm.2016.62660","journal-title":"Prz Menopauzalny"},{"issue":"1","key":"5071_CR80","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1210\/clinem\/dgaa764","volume":"106","author":"N Santoro","year":"2021","unstructured":"Santoro N, Roeca C, Peters BA, Neal-Perry G (2021) The menopause transition: signs, symptoms, and management options. J Clin Endocrinol Metab 106(1):1\u201315. https:\/\/doi.org\/10.1210\/clinem\/dgaa764","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"5071_CR81","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.3233\/JAD-201616","volume":"83","author":"L Yang","year":"2021","unstructured":"Yang L, Wu C, Tucker L, Dong Y, Li Y, Xu P et al (2021) Photobiomodulation therapy attenuates anxious-depressive-like behavior in the TgF344 rat model. J Alzheimers Dis 83(4):1415\u20131429. https:\/\/doi.org\/10.3233\/JAD-201616","journal-title":"J Alzheimers Dis"},{"issue":"10","key":"5071_CR82","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.4103\/1673-5374.308071","volume":"16","author":"H Kuang","year":"2021","unstructured":"Kuang H, Zhu YG, Zhou ZF, Yang MW, Hong FF, Yang SL (2021) Sleep disorders in Alzheimer\u2019s disease: the predictive roles and potential mechanisms. Neural Regen Res 16(10):1965\u20131972. https:\/\/doi.org\/10.4103\/1673-5374.308071","journal-title":"Neural Regen Res"},{"issue":"1","key":"5071_CR83","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1007\/s43440-022-00444-2","volume":"75","author":"J Turek","year":"2023","unstructured":"Turek J, Gasior L (2023) Estrogen fluctuations during the menopausal transition are a risk factor for depressive disorders. Pharmacol Rep 75(1):32\u201343. https:\/\/doi.org\/10.1007\/s43440-022-00444-2","journal-title":"Pharmacol Rep"},{"key":"5071_CR84","doi-asserted-by":"publisher","DOI":"10.3390\/cells10030540","author":"P Preman","year":"2021","unstructured":"Preman P, Alfonso-Triguero M, Alberdi E, Verkhratsky A, Arranz AM (2021) Astrocytes in Alzheimer\u2019s disease: pathological significance and molecular pathways. Cells. https:\/\/doi.org\/10.3390\/cells10030540","journal-title":"Cells"},{"issue":"12","key":"5071_CR85","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1016\/j.ebiom.2015.11.002","volume":"2","author":"LP Klosinski","year":"2015","unstructured":"Klosinski LP, Yao J, Yin F, Fonteh AN, Harrington MG, Christensen TA et al (2015) White matter lipids as a ketogenic fuel supply in aging female brain: implications for Alzheimer\u2019s disease. EBioMedicine 2(12):1888\u20131904. https:\/\/doi.org\/10.1016\/j.ebiom.2015.11.002","journal-title":"EBioMedicine"},{"issue":"4","key":"5071_CR86","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1002\/hbm.20394","volume":"29","author":"K Inoue","year":"2008","unstructured":"Inoue K, Ito H, Uchida S, Taki Y, Kinomura S, Tsuji I et al (2008) Decrease in glucose metabolism in frontal cortex associated with deterioration of microstructure of corpus callosum measured by diffusion tensor imaging in healthy elderly. Hum Brain Mapp 29(4):375\u2013384. https:\/\/doi.org\/10.1002\/hbm.20394","journal-title":"Hum Brain Mapp"},{"issue":"42","key":"5071_CR87","doi-asserted-by":"publisher","first-page":"eadd6155","DOI":"10.1126\/sciadv.add6155","volume":"8","author":"DJ Panyard","year":"2022","unstructured":"Panyard DJ, Yu B, Snyder MP (2022) The metabolomics of human aging: advances, challenges, and opportunities. Sci Adv 8(42):eadd6155. https:\/\/doi.org\/10.1126\/sciadv.add6155","journal-title":"Sci Adv"},{"issue":"1","key":"5071_CR88","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s13024-021-00456-1","volume":"16","author":"Y Chen","year":"2021","unstructured":"Chen Y, Dang M, Zhang Z (2021) Brain mechanisms underlying neuropsychiatric symptoms in Alzheimer\u2019s disease: a systematic review of symptom-general and -specific lesion patterns. Mol Neurodegener 16(1):38. https:\/\/doi.org\/10.1186\/s13024-021-00456-1","journal-title":"Mol Neurodegener"},{"issue":"4","key":"5071_CR89","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1055\/s-0033-1359312","volume":"33","author":"SL Risacher","year":"2013","unstructured":"Risacher SL, Saykin AJ (2013) Neuroimaging biomarkers of neurodegenerative diseases and dementia. Semin Neurol 33(4):386\u2013416. https:\/\/doi.org\/10.1055\/s-0033-1359312","journal-title":"Semin Neurol"},{"issue":"11","key":"5071_CR90","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.15252\/embj.201695810","volume":"36","author":"S Camandola","year":"2017","unstructured":"Camandola S, Mattson MP (2017) Brain metabolism in health, aging, and neurodegeneration. EMBO J 36(11):1474\u20131492. https:\/\/doi.org\/10.15252\/embj.201695810","journal-title":"EMBO J"},{"issue":"3","key":"5071_CR91","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/S1474-4422(05)01016-1","volume":"4","author":"MC Craig","year":"2005","unstructured":"Craig MC, Maki PM, Murphy DG (2005) The women\u2019s Health Initiative Memory Study: findings and implications for treatment. Lancet Neurol 4(3):190\u2013194. https:\/\/doi.org\/10.1016\/S1474-4422(05)01016-1","journal-title":"Lancet Neurol"},{"issue":"6","key":"5071_CR92","doi-asserted-by":"publisher","first-page":"101561","DOI":"10.1016\/j.beem.2021.101561","volume":"35","author":"E Armeni","year":"2021","unstructured":"Armeni E, Paschou SA, Goulis DG, Lambrinoudaki I (2021) Hormone therapy regimens for managing the menopause and premature ovarian insufficiency. Best Pract Res Clin Endocrinol Metab 35(6):101561. https:\/\/doi.org\/10.1016\/j.beem.2021.101561","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"2","key":"5071_CR93","doi-asserted-by":"publisher","first-page":"69","DOI":"10.6118\/jmm.20000","volume":"26","author":"SR Lee","year":"2020","unstructured":"Academic Committee of the Korean Society of Menopause, Lee SR, Cho MK, Cho YJ, Chun S, Hong SH et al (2020) The 2020 menopausal hormone therapy guidelines. J Menopausal Med 26(2):69\u201398. https:\/\/doi.org\/10.6118\/jmm.20000","journal-title":"J Menopausal Med"},{"issue":"1","key":"5071_CR94","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1161\/01.atv.0000046033.32478.6d","volume":"23","author":"LH Kuller","year":"2003","unstructured":"Kuller LH, Women\u2019s Health I (2003) Hormone replacement therapy and risk of cardiovascular disease: implications of the results of the women\u2019s Health Initiative. Arterioscler Thromb Vasc Biol 23(1):11\u201316. https:\/\/doi.org\/10.1161\/01.atv.0000046033.32478.6d","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"5071_CR95","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.socscimed.2015.02.027","volume":"132","author":"JR Fishman","year":"2015","unstructured":"Fishman JR, Flatt MA, Settersten RA Jr (2015) Bioidentical hormones, menopausal women, and the lure of the natural in U.S. anti-aging medicine. Soc Sci Med 132:79\u201387. https:\/\/doi.org\/10.1016\/j.socscimed.2015.02.027","journal-title":"Soc Sci Med"},{"issue":"2","key":"5071_CR96","doi-asserted-by":"publisher","first-page":"202","DOI":"10.3122\/jabfm.2011.02.100194","volume":"24","author":"R Sood","year":"2011","unstructured":"Sood R, Shuster L, Smith R, Vincent A, Jatoi A (2011) Counseling postmenopausal women about bioidentical hormones: ten discussion points for practicing physicians. J Am Board Fam Med 24(2):202\u2013210. https:\/\/doi.org\/10.3122\/jabfm.2011.02.100194","journal-title":"J Am Board Fam Med"},{"issue":"11","key":"5071_CR97","doi-asserted-by":"publisher","first-page":"3848","DOI":"10.1210\/en.2018-00600","volume":"159","author":"UM Selvaraj","year":"2018","unstructured":"Selvaraj UM, Zuurbier KR, Whoolery CW, Plautz EJ, Chambliss KL, Kong X et al (2018) Selective nonnuclear estrogen receptor activation decreases stroke severity and promotes functional recovery in female mice. Endocrinology 159(11):3848\u20133859. https:\/\/doi.org\/10.1210\/en.2018-00600","journal-title":"Endocrinology"},{"issue":"17","key":"5071_CR98","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1001\/jama.288.17.2123","volume":"288","author":"PP Zandi","year":"2002","unstructured":"Zandi PP, Carlson MC, Plassman BL, Welsh-Bohmer KA, Mayer LS, Steffens DC et al (2002) Hormone replacement therapy and incidence of Alzheimer disease in older women: the Cache County study. JAMA 288(17):2123\u20132129. https:\/\/doi.org\/10.1001\/jama.288.17.2123","journal-title":"JAMA"},{"key":"5071_CR99","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1350318","author":"C Andy","year":"2024","unstructured":"Andy C, Nerattini M, Jett S, Carlton C, Zarate C, Boneu C et al (2024) Systematic review and meta-analysis of the effects of menopause hormone therapy on cognition. Front Endocrinol (Lausanne). https:\/\/doi.org\/10.3389\/fendo.2024.1350318","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"13","key":"5071_CR100","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1001\/jama.2013.278040","volume":"310","author":"JE Manson","year":"2013","unstructured":"Manson JE, Chlebowski RT, Stefanick ML, Aragaki AK, Rossouw JE, Prentice RL et al (2013) Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the women\u2019s health initiative randomized trials. JAMA 310(13):1353\u20131368. https:\/\/doi.org\/10.1001\/jama.2013.278040","journal-title":"JAMA"},{"issue":"6","key":"5071_CR101","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1111\/psyg.12768","volume":"21","author":"HH Zhou","year":"2021","unstructured":"Zhou HH, Yu Z, Luo L, Xie F, Wang Y, Wan Z (2021) The effect of hormone replacement therapy on cognitive function in healthy postmenopausal women: a meta-analysis of 23 randomized controlled trials. Psychogeriatrics 21(6):926\u2013938. https:\/\/doi.org\/10.1111\/psyg.12768","journal-title":"Psychogeriatrics"},{"issue":"9","key":"5071_CR102","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1080\/14737175.2018.1510320","volume":"18","author":"L Mosconi","year":"2018","unstructured":"Mosconi L, Brinton RD (2018) How would we combat menopause as an Alzheimer\u2019s risk factor? Expert Rev Neurother 18(9):689\u2013691. https:\/\/doi.org\/10.1080\/14737175.2018.1510320","journal-title":"Expert Rev Neurother"},{"issue":"2","key":"5071_CR103","doi-asserted-by":"publisher","first-page":"fcaa109","DOI":"10.1093\/braincomms\/fcaa109","volume":"2","author":"J Rivers-Auty","year":"2020","unstructured":"Rivers-Auty J, Mather AE, Peters R, Lawrence CB, Brough D (2020) Anti-inflammatories in Alzheimer\u2019s disease\u2014potential therapy or spurious correlate? Brain Commun 2(2):fcaa109. https:\/\/doi.org\/10.1093\/braincomms\/fcaa109","journal-title":"Brain Commun"},{"key":"5071_CR104","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.brainres.2010.08.103","volume":"1379","author":"TJ Williams","year":"2011","unstructured":"Williams TJ, Mitterling KL, Thompson LI, Torres-Reveron A, Waters EM, McEwen BS et al (2011) Age- and hormone-regulation of opioid peptides and synaptic proteins in the rat dorsal hippocampal formation. Brain Res 1379:71\u201385. https:\/\/doi.org\/10.1016\/j.brainres.2010.08.103","journal-title":"Brain Res"},{"key":"5071_CR105","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.yhbeh.2015.04.012","volume":"74","author":"JM Daniel","year":"2015","unstructured":"Daniel JM, Witty CF, Rodgers SP (2015) Long-term consequences of estrogens administered in midlife on female cognitive aging. Horm Behav 74:77\u201385. https:\/\/doi.org\/10.1016\/j.yhbeh.2015.04.012","journal-title":"Horm Behav"},{"issue":"10","key":"5071_CR106","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.tins.2008.07.003","volume":"31","author":"RD Brinton","year":"2008","unstructured":"Brinton RD (2008) The healthy cell bias of estrogen action: mitochondrial bioenergetics and neurological implications. Trends Neurosci 31(10):529\u2013537. https:\/\/doi.org\/10.1016\/j.tins.2008.07.003","journal-title":"Trends Neurosci"},{"key":"5071_CR107","doi-asserted-by":"publisher","first-page":"107201","DOI":"10.1016\/j.phrs.2024.107201","volume":"204","author":"W He","year":"2024","unstructured":"He W, Zhang S, Qi Z, Liu W (2024) Unveiling the potential of estrogen: exploring its role in neuropsychiatric disorders and exercise intervention. Pharmacol Res 204:107201. https:\/\/doi.org\/10.1016\/j.phrs.2024.107201","journal-title":"Pharmacol Res"},{"issue":"1","key":"5071_CR108","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s40035-020-00221-2","volume":"9","author":"HS Kwon","year":"2020","unstructured":"Kwon HS, Koh SH (2020) Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes. Transl Neurodegener 9(1):42. https:\/\/doi.org\/10.1186\/s40035-020-00221-2","journal-title":"Transl Neurodegener"},{"issue":"4","key":"5071_CR109","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.cmet.2023.03.006","volume":"35","author":"P Hasel","year":"2023","unstructured":"Hasel P, Aisenberg WH, Bennett FC, Liddelow SA (2023) Molecular and metabolic heterogeneity of astrocytes and microglia. Cell Metab 35(4):555\u2013570. https:\/\/doi.org\/10.1016\/j.cmet.2023.03.006","journal-title":"Cell Metab"},{"key":"5071_CR110","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-024-03931-0","author":"C Wu","year":"2024","unstructured":"Wu C, Deng Q, Zhu L, Liu TC, Duan R, Yang L (2024) Methylene blue pretreatment protects against repeated neonatal isoflurane exposure-induced brain injury and memory loss. Mol Neurobiol. https:\/\/doi.org\/10.1007\/s12035-024-03931-0","journal-title":"Mol Neurobiol"},{"key":"5071_CR111","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.3389\/fimmu.2020.01024","volume":"11","author":"LR Liu","year":"2020","unstructured":"Liu LR, Liu JC, Bao JS, Bai QQ, Wang GQ (2020) Interaction of microglia and astrocytes in the neurovascular unit. Front Immunol 11:1024. https:\/\/doi.org\/10.3389\/fimmu.2020.01024","journal-title":"Front Immunol"},{"issue":"Pt A","key":"5071_CR112","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.expneurol.2017.10.013","volume":"299","author":"L Yang","year":"2018","unstructured":"Yang L, Tucker D, Dong Y, Wu C, Lu Y, Li Y et al (2018) Photobiomodulation therapy promotes neurogenesis by improving post-stroke local microenvironment and stimulating neuroprogenitor cells. Exp Neurol 299(Pt A):86\u201396. https:\/\/doi.org\/10.1016\/j.expneurol.2017.10.013","journal-title":"Exp Neurol"},{"issue":"1\u20132","key":"5071_CR113","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.mce.2013.12.018","volume":"389","author":"R Li","year":"2014","unstructured":"Li R, Cui J, Shen Y (2014) Brain sex matters: estrogen in cognition and Alzheimer\u2019s disease. Mol Cell Endocrinol 389(1\u20132):13\u201321. https:\/\/doi.org\/10.1016\/j.mce.2013.12.018","journal-title":"Mol Cell Endocrinol"},{"key":"5071_CR114","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1196\/annals.1286.028","volume":"1007","author":"I Azcoitia","year":"2003","unstructured":"Azcoitia I, Sierra A, Veiga S, Garcia-Segura LM (2003) Aromatase expression by reactive astroglia is neuroprotective. Ann N Y Acad Sci 1007:298\u2013305. https:\/\/doi.org\/10.1196\/annals.1286.028","journal-title":"Ann N Y Acad Sci"},{"issue":"50","key":"5071_CR115","doi-asserted-by":"publisher","first-page":"9751","DOI":"10.1523\/JNEUROSCI.0888-20.2020","volume":"40","author":"J Wang","year":"2020","unstructured":"Wang J, Sareddy GR, Lu Y, Pratap UP, Tang F, Greene KM et al (2020) Astrocyte-derived estrogen regulates reactive astrogliosis and is neuroprotective following ischemic brain Injury. J Neurosci 40(50):9751\u20139771. https:\/\/doi.org\/10.1523\/JNEUROSCI.0888-20.2020","journal-title":"J Neurosci"},{"issue":"1","key":"5071_CR116","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1124\/jpet.119.264598","volume":"375","author":"M Acosta-Martinez","year":"2020","unstructured":"Acosta-Martinez M (2020) Shaping microglial phenotypes through estrogen receptors: relevance to sex-specific neuroinflammatory responses to brain injury and disease. J Pharmacol Exp Ther 375(1):223\u2013236. https:\/\/doi.org\/10.1124\/jpet.119.264598","journal-title":"J Pharmacol Exp Ther"},{"key":"5071_CR117","doi-asserted-by":"publisher","first-page":"100897","DOI":"10.1016\/j.yfrne.2020.100897","volume":"60","author":"GM Rurak","year":"2021","unstructured":"Rurak GM, Woodside B, Aguilar-Valles A, Salmaso N (2021) Astroglial cells as neuroendocrine targets in forebrain development: implications for sex differences in psychiatric disease. Front Neuroendocrinol 60:100897. https:\/\/doi.org\/10.1016\/j.yfrne.2020.100897","journal-title":"Front Neuroendocrinol"},{"issue":"1\u20132","key":"5071_CR118","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.mce.2014.01.010","volume":"389","author":"P Karki","year":"2014","unstructured":"Karki P, Smith K, Johnson J Jr., Lee E (2014) Astrocyte-derived growth factors and estrogen neuroprotection: role of transforming growth factor-alpha in estrogen-induced upregulation of glutamate transporters in astrocytes. Mol Cell Endocrinol 389(1\u20132):58\u201364. https:\/\/doi.org\/10.1016\/j.mce.2014.01.010","journal-title":"Mol Cell Endocrinol"},{"key":"5071_CR119","doi-asserted-by":"publisher","first-page":"107559","DOI":"10.1016\/j.neuropharm.2019.03.002","volume":"161","author":"E Pajarillo","year":"2019","unstructured":"Pajarillo E, Rizor A, Lee J, Aschner M, Lee E (2019) The role of astrocytic glutamate transporters GLT-1 and GLAST in neurological disorders: potential targets for neurotherapeutics. Neuropharmacology 161:107559. https:\/\/doi.org\/10.1016\/j.neuropharm.2019.03.002","journal-title":"Neuropharmacology"},{"key":"5071_CR120","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2023.0907","author":"Q Deng","year":"2023","unstructured":"Deng Q, Wu C, Parker E, Liu TC, Duan R, Yang L (2023) Microglia and astrocytes in Alzheimer\u2019s disease: significance and summary of recent advances. Aging Dis. https:\/\/doi.org\/10.14336\/AD.2023.0907","journal-title":"Aging Dis"},{"issue":"10","key":"5071_CR121","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1007\/s12264-022-00907-9","volume":"38","author":"L Yang","year":"2022","unstructured":"Yang L, Feng S, Wu C, Yang L (2022) Microglia-mediated abeta propagation in Alzheimer\u2019s disease. Neurosci Bull 38(10):1274\u20131276. https:\/\/doi.org\/10.1007\/s12264-022-00907-9","journal-title":"Neurosci Bull"},{"issue":"2","key":"5071_CR122","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1007\/s12264-021-00795-5","volume":"38","author":"C Wu","year":"2022","unstructured":"Wu C, Yang L, Youngblood H, Liu TC, Duan R (2022) Microglial SIRPalpha deletion facilitates synapse loss in preclinical models of neurodegeneration. Neurosci Bull 38(2):232\u2013234. https:\/\/doi.org\/10.1007\/s12264-021-00795-5","journal-title":"Neurosci Bull"},{"issue":"10","key":"5071_CR123","doi-asserted-by":"publisher","first-page":"e2212646120","DOI":"10.1073\/pnas.2212646120","volume":"120","author":"LA Pickett","year":"2023","unstructured":"Pickett LA, VanRyzin JW, Marquardt AE, McCarthy MM (2023) Microglia phagocytosis mediates the volume and function of the rat sexually dimorphic nucleus of the preoptic area. Proc Natl Acad Sci U S A 120(10):e2212646120. https:\/\/doi.org\/10.1073\/pnas.2212646120","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5071_CR124","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuint.2018.03.004","volume":"116","author":"J Zhang","year":"2018","unstructured":"Zhang J, Tucker LD, DongYan, Lu Y, Yang L, Wu C et al (2018) Tert-butylhydroquinone post-treatment attenuates neonatal hypoxic-ischemic brain damage in rats. Neurochem Int 116:1\u201312. https:\/\/doi.org\/10.1016\/j.neuint.2018.03.004","journal-title":"Neurochem Int"},{"issue":"4","key":"5071_CR125","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1002\/(sici)1097-4695(19990915)40:4<484::aid-neu6>3.0.co;2-c","volume":"40","author":"G Mor","year":"1999","unstructured":"Mor G, Nilsen J, Horvath T, Bechmann I, Brown S, Garcia-Segura LM et al (1999) Estrogen and microglia: a regulatory system that affects the brain. J Neurobiol 40(4):484\u2013496. https:\/\/doi.org\/10.1002\/(sici)1097-4695(19990915)40:4%3c484::aid-neu6%3e3.0.co;2-c","journal-title":"J Neurobiol"},{"issue":"5","key":"5071_CR126","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.7150\/thno.70756","volume":"12","author":"L Yang","year":"2022","unstructured":"Yang L, Wu C, Parker E, Li Y, Dong Y, Tucker L et al (2022) Non-invasive photobiomodulation treatment in an Alzheimer disease-like transgenic rat model. Theranostics 12(5):2205\u20132231. https:\/\/doi.org\/10.7150\/thno.70756","journal-title":"Theranostics"},{"issue":"3","key":"5071_CR127","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1007\/s11357-022-00534-2","volume":"44","author":"L Yang","year":"2022","unstructured":"Yang L, Wu C, Li Y, Dong Y, Wu CY, Lee RH et al (2022) Long-term exercise pre-training attenuates Alzheimer\u2019s disease-related pathology in a transgenic rat model of Alzheimer\u2019s disease. Geroscience 44(3):1457\u20131477. https:\/\/doi.org\/10.1007\/s11357-022-00534-2","journal-title":"Geroscience"},{"key":"5071_CR128","doi-asserted-by":"publisher","DOI":"10.3390\/cells11172728","author":"G Di Benedetto","year":"2022","unstructured":"Di Benedetto G, Burgaletto C, Bellanca CM, Munafo A, Bernardini R, Cantarella G (2022) Role of microglia and astrocytes in Alzheimer\u2019s disease: from neuroinflammation to Ca2+ homeostasis dysregulation. Cells. https:\/\/doi.org\/10.3390\/cells11172728","journal-title":"Cells"},{"issue":"1","key":"5071_CR129","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s40035-020-00197-z","volume":"9","author":"L Yang","year":"2020","unstructured":"Yang L, Youngblood H, Wu C, Zhang Q (2020) Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation. Transl Neurodegener 9(1):19. https:\/\/doi.org\/10.1186\/s40035-020-00197-z","journal-title":"Transl Neurodegener"},{"issue":"4","key":"5071_CR130","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s10787-019-00580-x","volume":"27","author":"D Kaur","year":"2019","unstructured":"Kaur D, Sharma V, Deshmukh R (2019) Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer\u2019s disease. Inflammopharmacology 27(4):663\u2013677. https:\/\/doi.org\/10.1007\/s10787-019-00580-x","journal-title":"Inflammopharmacology"},{"key":"5071_CR131","doi-asserted-by":"publisher","first-page":"1260427","DOI":"10.3389\/fnagi.2023.1260427","volume":"15","author":"M Nerattini","year":"2023","unstructured":"Nerattini M, Jett S, Andy C, Carlton C, Zarate C, Boneu C et al (2023) Systematic review and meta-analysis of the effects of menopause hormone therapy on risk of Alzheimer\u2019s disease and dementia. Front Aging Neurosci 15:1260427. https:\/\/doi.org\/10.3389\/fnagi.2023.1260427","journal-title":"Front Aging Neurosci"},{"issue":"8","key":"5071_CR132","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1111\/ene.14315","volume":"27","author":"JE Yoo","year":"2020","unstructured":"Yoo JE, Shin DW, Han K, Kim D, Won HS, Lee J et al (2020) Female reproductive factors and the risk of dementia: a nationwide cohort study. Eur J Neurol 27(8):1448\u20131458. https:\/\/doi.org\/10.1111\/ene.14315","journal-title":"Eur J Neurol"},{"issue":"24","key":"5071_CR133","doi-asserted-by":"publisher","first-page":"2947","DOI":"10.1001\/jama.291.24.2947","volume":"291","author":"SA Shumaker","year":"2004","unstructured":"Shumaker SA, Legault C, Kuller L, Rapp SR, Thal L, Lane DS et al (2004) Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women\u2019s Health Initiative Memory Study. JAMA 291(24):2947\u20132958. https:\/\/doi.org\/10.1001\/jama.291.24.2947","journal-title":"JAMA"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-024-05071-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-024-05071-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-024-05071-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T15:04:16Z","timestamp":1743692656000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-024-05071-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,1]]},"references-count":133,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["5071"],"URL":"https:\/\/doi.org\/10.1007\/s11010-024-05071-4","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,1]]},"assertion":[{"value":"11 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"N\/A.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"N\/A.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"N\/A.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}