{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:49:13Z","timestamp":1787503753420,"version":"build-2736575974"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Sciences Foundation of China","doi-asserted-by":"crossref","award":["82170838"],"award-info":[{"award-number":["82170838"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Sciences Foundation of China","doi-asserted-by":"crossref","award":["81770859"],"award-info":[{"award-number":["81770859"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Sciences Foundation of China","doi-asserted-by":"crossref","award":["31771307"],"award-info":[{"award-number":["31771307"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Sciences Foundation of China","doi-asserted-by":"crossref","award":["91957115"],"award-info":[{"award-number":["91957115"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Sciences Foundation of China","doi-asserted-by":"crossref","award":["32201064"],"award-info":[{"award-number":["32201064"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Sciences Foundation of China","doi-asserted-by":"crossref","award":["82170838"],"award-info":[{"award-number":["82170838"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Sciences Foundation of China","doi-asserted-by":"crossref","award":["81770859"],"award-info":[{"award-number":["81770859"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Sciences Foundation of China","doi-asserted-by":"crossref","award":["31771307"],"award-info":[{"award-number":["31771307"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Sciences Foundation of China","doi-asserted-by":"crossref","award":["91957115"],"award-info":[{"award-number":["91957115"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Sciences Foundation of China","doi-asserted-by":"crossref","award":["32201064"],"award-info":[{"award-number":["32201064"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"R&D Program of Guangzhou National Laboratory","award":["SRPG23-GZNL2023A02008"],"award-info":[{"award-number":["SRPG23-GZNL2023A02008"]}]},{"name":"Foundation of Jiangsu Health Development Research Center","award":["JSHD2021048"],"award-info":[{"award-number":["JSHD2021048"]}]},{"name":"Foundation of Jiangsu Commission of Health","award":["ZD2021030"],"award-info":[{"award-number":["ZD2021030"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1007\/s11010-024-05085-y","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T04:11:55Z","timestamp":1724386315000},"page":"1715-1730","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Inhibition of STRA6 suppresses NSCLC growth via blocking STAT3\/SREBP-1c axis-mediated lipogenesis"],"prefix":"10.1007","volume":"480","author":[{"given":"Yue","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingfeng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenzi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijia","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Zhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,21]]},"reference":[{"key":"5085_CR1","doi-asserted-by":"publisher","first-page":"4362","DOI":"10.1038\/s41467-021-24656-x","volume":"12","author":"LY Li","year":"2021","unstructured":"Li LY, Yang Q, Jiang YY, Yang W, Jiang Y, Li X, Hazawa M, Zhou B, Huang GW, Xu XE, Gery S, Zhang Y, Ding LW, Ho AS, Zumsteg ZS, Wang MR, Fullwood MJ, Freedland SJ, Meltzer SJ, Xu LY, Li EM, Koeffler HP, Lin DC (2021) Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer. Nat Commun 12:4362. https:\/\/doi.org\/10.1038\/s41467-021-24656-x","journal-title":"Nat Commun"},{"key":"5085_CR2","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.cmet.2015.12.006","volume":"23","author":"NN Pavlova","year":"2016","unstructured":"Pavlova NN, Thompson CB (2016) The emerging hallmarks of cancer metabolism. Cell Metab 23:27\u201347. https:\/\/doi.org\/10.1016\/j.cmet.2015.12.006","journal-title":"Cell Metab"},{"key":"5085_CR3","doi-asserted-by":"publisher","first-page":"4932","DOI":"10.1158\/0008-5472.CAN-20-1255","volume":"80","author":"CN Rozeveld","year":"2020","unstructured":"Rozeveld CN, Johnson KM, Zhang L, Razidlo GL (2020) KRAS controls pancreatic cancer cell lipid metabolism and invasive potential through the lipase HSL. Cancer Res 80:4932\u20134945. https:\/\/doi.org\/10.1158\/0008-5472.CAN-20-1255","journal-title":"Cancer Res"},{"key":"5085_CR4","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.canlet.2019.11.032","volume":"470","author":"M Zhao","year":"2020","unstructured":"Zhao M, Bu Y, Feng J, Zhang H, Chen Y, Yang G, Liu Z, Yuan H, Yuan Y, Liu L, Yun H, Wang J, Zhang X (2020) SPIN1 triggers abnormal lipid metabolism and enhances tumor growth in liver cancer. Cancer Lett 470:54\u201363. https:\/\/doi.org\/10.1016\/j.canlet.2019.11.032","journal-title":"Cancer Lett"},{"key":"5085_CR5","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/s41419-022-04506-4","volume":"13","author":"C Zhang","year":"2022","unstructured":"Zhang C, Wang XY, Zhang P, He TC, Han JH, Zhang R, Lin J, Fan J, Lu L, Zhu WW, Jia HL, Zhang JB, Chen JH (2022) Cancer-derived exosomal HSPC111 promotes colorectal cancer liver metastasis by reprogramming lipid metabolism in cancer-associated fibroblasts. Cell Death Dis 13:57. https:\/\/doi.org\/10.1038\/s41419-022-04506-4","journal-title":"Cell Death Dis"},{"key":"5085_CR6","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201606","author":"X Bian","year":"2021","unstructured":"Bian X, Liu R, Meng Y, Xing D, Xu D, Lu Z (2021) Lipid metabolism and cancer. J Exp Med. https:\/\/doi.org\/10.1084\/jem.20201606","journal-title":"J Exp Med"},{"key":"5085_CR7","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1038\/nrc.2016.89","volume":"16","author":"F Rohrig","year":"2016","unstructured":"Rohrig F, Schulze A (2016) The multifaceted roles of fatty acid synthesis in cancer. Nat Rev Cancer 16:732\u2013749. https:\/\/doi.org\/10.1038\/nrc.2016.89","journal-title":"Nat Rev Cancer"},{"key":"5085_CR8","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/s12943-017-0646-3","volume":"16","author":"X Luo","year":"2017","unstructured":"Luo X, Cheng C, Tan Z, Li N, Tang M, Yang L, Cao Y (2017) Emerging roles of lipid metabolism in cancer metastasis. Mol Cancer 16:76. https:\/\/doi.org\/10.1186\/s12943-017-0646-3","journal-title":"Mol Cancer"},{"key":"5085_CR9","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s40170-016-0146-8","volume":"4","author":"B Peck","year":"2016","unstructured":"Peck B, Schug ZT, Zhang Q, Dankworth B, Jones DT, Smethurst E, Patel R, Mason S, Jiang M, Saunders R, Howell M, Mitter R, Spencer-Dene B, Stamp G, McGarry L, James D, Shanks E, Aboagye EO, Critchlow SE, Leung HY, Harris AL, Wakelam MJO, Gottlieb E, Schulze A (2016) Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments. Cancer Metab 4:6. https:\/\/doi.org\/10.1186\/s40170-016-0146-8","journal-title":"Cancer Metab"},{"key":"5085_CR10","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.tem.2011.10.004","volume":"23","author":"TI Jeon","year":"2012","unstructured":"Jeon TI, Osborne TF (2012) SREBPs: metabolic integrators in physiology and metabolism. Trends Endocrinol Metab 23:65\u201372. https:\/\/doi.org\/10.1016\/j.tem.2011.10.004","journal-title":"Trends Endocrinol Metab"},{"key":"5085_CR11","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.cell.2005.12.022","volume":"124","author":"JL Goldstein","year":"2006","unstructured":"Goldstein JL, DeBose-Boyd RA, Brown MS (2006) Protein sensors for membrane sterols. Cell 124:35\u201346. https:\/\/doi.org\/10.1016\/j.cell.2005.12.022","journal-title":"Cell"},{"key":"5085_CR12","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1038\/nrendo.2017.91","volume":"13","author":"H Shimano","year":"2017","unstructured":"Shimano H, Sato R (2017) SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology. Nat Rev Endocrinol 13:710\u2013730. https:\/\/doi.org\/10.1038\/nrendo.2017.91","journal-title":"Nat Rev Endocrinol"},{"key":"5085_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/nu12010066","author":"YH Han","year":"2019","unstructured":"Han YH, Mun JG, Jeon HD, Kee JY, Hong SH (2019) Betulin inhibits lung metastasis by inducing cell cycle arrest, autophagy, and apoptosis of metastatic colorectal cancer cells. Nutrients. https:\/\/doi.org\/10.3390\/nu12010066","journal-title":"Nutrients"},{"key":"5085_CR14","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/s41389-018-0076-0","volume":"7","author":"V Brovkovych","year":"2018","unstructured":"Brovkovych V, Izhar Y, Danes JM, Dubrovskyi O, Sakallioglu IT, Morrow LM, Atilla-Gokcumen GE, Frasor J (2018) Fatostatin induces pro- and anti-apoptotic lipid accumulation in breast cancer. Oncogenesis 7:66. https:\/\/doi.org\/10.1038\/s41389-018-0076-0","journal-title":"Oncogenesis"},{"key":"5085_CR15","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71:209\u2013249. https:\/\/doi.org\/10.3322\/caac.21660","journal-title":"CA Cancer J Clin"},{"key":"5085_CR16","doi-asserted-by":"publisher","first-page":"1940","DOI":"10.1016\/j.ajpath.2010.12.057","volume":"178","author":"C Moran","year":"2011","unstructured":"Moran C (2011) Importance of molecular features of non-small cell lung cancer for choice of treatment. Am J Pathol 178:1940\u20131948. https:\/\/doi.org\/10.1016\/j.ajpath.2010.12.057","journal-title":"Am J Pathol"},{"key":"5085_CR17","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1038\/nature25183","volume":"553","author":"RS Herbst","year":"2018","unstructured":"Herbst RS, Morgensztern D, Boshoff C (2018) The biology and management of non-small cell lung cancer. Nature 553:446\u2013454. https:\/\/doi.org\/10.1038\/nature25183","journal-title":"Nature"},{"key":"5085_CR18","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1007\/s12272-001-1157-x","volume":"31","author":"K Kim","year":"2008","unstructured":"Kim K, Kim HL, Lee YK, Han M, Sacket SJ, Jo JY, Kim YL, Im DS (2008) Lysophosphatidylserine induces calcium signaling through Ki16425\/VPC32183-sensitive GPCR in bone marrow-derived mast cells and in C6 glioma and colon cancer cells. Arch Pharm Res 31:310\u2013317. https:\/\/doi.org\/10.1007\/s12272-001-1157-x","journal-title":"Arch Pharm Res"},{"key":"5085_CR19","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1111\/imcb.12025","volume":"96","author":"MJ Barnes","year":"2018","unstructured":"Barnes MJ, Cyster JG (2018) Lysophosphatidylserine suppression of T-cell activation via GPR174 requires Galphas proteins. Immunol Cell Biol 96:439\u2013445. https:\/\/doi.org\/10.1111\/imcb.12025","journal-title":"Immunol Cell Biol"},{"key":"5085_CR20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021320","volume":"6","author":"R Mancini","year":"2011","unstructured":"Mancini R, Giarnieri E, De Vitis C, Malanga D, Roscilli G, Noto A, Marra E, Laudanna C, Zoppoli P, De Luca P, Affuso A, Ruco L, Di Napoli A, Mesiti G, Aurisicchio L, Ricci A, Mariotta S, Pisani L, Andreetti C, Viglietto G, Rendina EA, Giovagnoli MR, Ciliberto G (2011) Spheres derived from lung adenocarcinoma pleural effusions: molecular characterization and tumor engraftment. PLoS ONE 6:e21320. https:\/\/doi.org\/10.1371\/journal.pone.0021320","journal-title":"PLoS ONE"},{"key":"5085_CR21","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.critrevonc.2017.02.001","volume":"112","author":"M Merino Salvador","year":"2017","unstructured":"Merino Salvador M, Gomez de Cedron M, Moreno Rubio J, Falagan Martinez S, Sanchez Martinez R, Casado E, Ramirez de Molina A, Sereno M (2017) Lipid metabolism and lung cancer. Crit Rev Oncol Hematol 112:31\u201340. https:\/\/doi.org\/10.1016\/j.critrevonc.2017.02.001","journal-title":"Crit Rev Oncol Hematol"},{"key":"5085_CR22","doi-asserted-by":"publisher","first-page":"4340","DOI":"10.1073\/pnas.1011115108","volume":"108","author":"DC Berry","year":"2011","unstructured":"Berry DC, Jin H, Majumdar A, Noy N (2011) Signaling by vitamin A and retinol-binding protein regulates gene expression to inhibit insulin responses. Proc Natl Acad Sci USA 108:4340\u20134345. https:\/\/doi.org\/10.1073\/pnas.1011115108","journal-title":"Proc Natl Acad Sci USA"},{"key":"5085_CR23","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad8266","author":"Y Chen","year":"2016","unstructured":"Chen Y, Clarke OB, Kim J, Stowe S, Kim YK, Assur Z, Cavalier M, Godoy-Ruiz R, von Alpen DC, Manzini C, Blaner WS, Frank J, Quadro L, Weber DJ, Shapiro L, Hendrickson WA, Mancia F (2016) Structure of the STRA6 receptor for retinol uptake. Science. https:\/\/doi.org\/10.1126\/science.aad8266","journal-title":"Science"},{"key":"5085_CR24","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1186\/s13046-019-1450-2","volume":"38","author":"L Lin","year":"2019","unstructured":"Lin L, Xiao J, Shi L, Chen W, Ge Y, Jiang M, Li Z, Fan H, Yang L, Xu Z (2019) STRA6 exerts oncogenic role in gastric tumorigenesis by acting as a crucial target of miR-873. J Exp Clin Cancer Res 38:452. https:\/\/doi.org\/10.1186\/s13046-019-1450-2","journal-title":"J Exp Clin Cancer Res"},{"key":"5085_CR25","doi-asserted-by":"publisher","first-page":"6341","DOI":"10.1158\/0008-5472.CAN-14-1052","volume":"74","author":"DC Berry","year":"2014","unstructured":"Berry DC, Levi L, Noy N (2014) Holo-retinol-binding protein and its receptor STRA6 drive oncogenic transformation. Cancer Res 74:6341\u20136351. https:\/\/doi.org\/10.1158\/0008-5472.CAN-14-1052","journal-title":"Cancer Res"},{"key":"5085_CR26","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.579561","volume":"10","author":"S Muniz-Hernandez","year":"2020","unstructured":"Muniz-Hernandez S, Velazquez-Fernandez JB, Diaz-Chavez J, Mondragon-Fonseca O, Mayen-Lobo Y, Ortega A, Lopez-Lopez M, Arrieta O (2020) STRA6 polymorphisms are associated with EGFR mutations in locally-advanced and metastatic non-small cell lung cancer patients. Front Oncol 10:579561. https:\/\/doi.org\/10.3389\/fonc.2020.579561","journal-title":"Front Oncol"},{"key":"5085_CR27","doi-asserted-by":"publisher","first-page":"509","DOI":"10.21873\/cgp.20207","volume":"17","author":"S Nakamura","year":"2020","unstructured":"Nakamura S, Kanda M, Shimizu D, Sawaki K, Tanaka C, Hattori N, Hayashi M, Yamada S, Nakayama G, Omae K, Koike M, Kodera Y (2020) STRA6 expression serves as a prognostic biomarker of gastric cancer. Cancer Genomics Proteomics 17:509\u2013516. https:\/\/doi.org\/10.21873\/cgp.20207","journal-title":"Cancer Genomics Proteomics"},{"key":"5085_CR28","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.biochi.2006.09.021","volume":"89","author":"J Aoki","year":"2007","unstructured":"Aoki J, Inoue A, Makide K, Saiki N, Arai H (2007) Structure and function of extracellular phospholipase A1 belonging to the pancreatic lipase gene family. Biochimie 89:197\u2013204. https:\/\/doi.org\/10.1016\/j.biochi.2006.09.021","journal-title":"Biochimie"},{"key":"5085_CR29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038522","volume":"7","author":"Q Wang","year":"2012","unstructured":"Wang Q, Chen J, Wang Y, Han X, Chen X (2012) Hepatitis C virus induced a novel apoptosis-like death of pancreatic beta cells through a caspase 3-dependent pathway. PLoS ONE 7:e38522. https:\/\/doi.org\/10.1371\/journal.pone.0038522","journal-title":"PLoS ONE"},{"key":"5085_CR30","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/s41419-018-0457-5","volume":"9","author":"Y Zhou","year":"2018","unstructured":"Zhou Y, Zhang Z, Wang N, Chen J, Zhang X, Guo M, John Zhong L, Wang Q (2018) Suppressor of cytokine signalling-2 limits IGF1R-mediated regulation of epithelial-mesenchymal transition in lung adenocarcinoma. Cell Death Dis 9:429. https:\/\/doi.org\/10.1038\/s41419-018-0457-5","journal-title":"Cell Death Dis"},{"key":"5085_CR31","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s40880-018-0301-4","volume":"38","author":"C Cheng","year":"2018","unstructured":"Cheng C, Geng F, Cheng X, Guo D (2018) Lipid metabolism reprogramming and its potential targets in cancer. Cancer Commun (Lond) 38:27. https:\/\/doi.org\/10.1186\/s40880-018-0301-4","journal-title":"Cancer Commun (Lond)"},{"key":"5085_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2020.100933","volume":"78","author":"E Piccinin","year":"2021","unstructured":"Piccinin E, Cariello M, Moschetta A (2021) Lipid metabolism in colon cancer: role of liver X receptor (LXR) and Stearoyl-CoA Desaturase 1 (SCD1). Mol Aspects Med 78:100933. https:\/\/doi.org\/10.1016\/j.mam.2020.100933","journal-title":"Mol Aspects Med"},{"key":"5085_CR33","doi-asserted-by":"publisher","DOI":"10.3390\/cells10010175","author":"AM Rizzo","year":"2021","unstructured":"Rizzo AM, Colombo I, Montorfano G, Zava S, Corsetto PA (2021) Exogenous Fatty Acids Modulate ER Lipid Composition and Metabolism in Breast Cancer Cells. Cells. https:\/\/doi.org\/10.3390\/cells10010175","journal-title":"Cells"},{"key":"5085_CR34","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.stemcr.2017.06.002","volume":"9","author":"S Karunanithi","year":"2017","unstructured":"Karunanithi S, Levi L, DeVecchio J, Karagkounis G, Reizes O, Lathia JD, Kalady MF, Noy N (2017) RBP4-STRA6 pathway drives cancer stem cell maintenance and mediates high-fat diet-induced colon carcinogenesis. Stem Cell Rep 9:438\u2013450. https:\/\/doi.org\/10.1016\/j.stemcr.2017.06.002","journal-title":"Stem Cell Rep"},{"key":"5085_CR35","first-page":"4197","volume":"61","author":"W Szeto","year":"2001","unstructured":"Szeto W, Jiang W, Tice DA, Rubinfeld B, Hollingshead PG, Fong SE, Dugger DL, Pham T, Yansura DG, Wong TA, Grimaldi JC, Corpuz RT, Singh JS, Frantz GD, Devaux B, Crowley CW, Schwall RH, Eberhard DA, Rastelli L, Polakis P, Pennica D (2001) Overexpression of the retinoic acid-responsive gene Stra6 in human cancers and its synergistic induction by Wnt-1 and retinoic acid. Cancer Res 61:4197\u20134205","journal-title":"Cancer Res"},{"key":"5085_CR36","doi-asserted-by":"publisher","unstructured":"Li M, Wang Z, Zhu L, Shui Y, Zhang S, Guo W (2021) Down-regulation of RBP4 indicates a poor prognosis and correlates with immune cell infiltration in hepatocellular carcinoma. Biosci Rep. https:\/\/doi.org\/10.1042\/BSR20210328","DOI":"10.1042\/BSR20210328"},{"key":"5085_CR37","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3892\/ol.2020.12346","volume":"21","author":"D Tsakogiannis","year":"2021","unstructured":"Tsakogiannis D, Kalogera E, Zagouri F, Zografos E, Balalis D, Bletsa G (2021) Determination of FABP4, RBP4 and the MMP-9\/NGAL complex in the serum of women with breast cancer. Oncol Lett 21:85. https:\/\/doi.org\/10.3892\/ol.2020.12346","journal-title":"Oncol Lett"},{"key":"5085_CR38","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s13048-018-0397-9","volume":"11","author":"Y Wang","year":"2018","unstructured":"Wang Y, Wang Y, Zhang Z (2018) Adipokine RBP4 drives ovarian cancer cell migration. J Ovarian Res 11:29. https:\/\/doi.org\/10.1186\/s13048-018-0397-9","journal-title":"J Ovarian Res"},{"key":"5085_CR39","doi-asserted-by":"publisher","first-page":"4770","DOI":"10.1158\/0008-5472.CAN-13-0384","volume":"73","author":"L Levi","year":"2013","unstructured":"Levi L, Lobo G, Doud MK, von Lintig J, Seachrist D, Tochtrop GP, Noy N (2013) Genetic ablation of the fatty acid-binding protein FABP5 suppresses HER2-induced mammary tumorigenesis. Cancer Res 73:4770\u20134780. https:\/\/doi.org\/10.1158\/0008-5472.CAN-13-0384","journal-title":"Cancer Res"},{"key":"5085_CR40","first-page":"4426","volume":"63","author":"D Manor","year":"2003","unstructured":"Manor D, Shmidt EN, Budhu A, Flesken-Nikitin A, Zgola M, Page R, Nikitin AY, Noy N (2003) Mammary carcinoma suppression by cellular retinoic acid binding protein-II. Cancer Res 63:4426\u20134433","journal-title":"Cancer Res"},{"key":"5085_CR41","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1038\/s41586-020-2183-2","volume":"580","author":"D Xu","year":"2020","unstructured":"Xu D, Wang Z, Xia Y, Shao F, Xia W, Wei Y, Li X, Qian X, Lee JH, Du L, Zheng Y, Lv G, Leu JS, Wang H, Xing D, Liang T, Hung MC, Lu Z (2020) The gluconeogenic enzyme PCK1 phosphorylates INSIG1\/2 for lipogenesis. Nature 580:530\u2013535. https:\/\/doi.org\/10.1038\/s41586-020-2183-2","journal-title":"Nature"},{"key":"5085_CR42","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1002\/cac2.12341","volume":"42","author":"W Dai","year":"2022","unstructured":"Dai W, Xiang W, Han L, Yuan Z, Wang R, Ma Y, Yang Y, Cai S, Xu Y, Mo S, Li Q, Cai G (2022) PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism. Cancer Commun (Lond) 42:848\u2013867. https:\/\/doi.org\/10.1002\/cac2.12341","journal-title":"Cancer Commun (Lond)"},{"key":"5085_CR43","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.canlet.2021.12.018","volume":"527","author":"X Li","year":"2022","unstructured":"Li X, Liu Z, Xia C, Yan K, Fang Z, Fan Y (2022) SETD8 stabilized by USP17 epigenetically activates SREBP1 pathway to drive lipogenesis and oncogenesis of ccRCC. Cancer Lett 527:150\u2013163. https:\/\/doi.org\/10.1016\/j.canlet.2021.12.018","journal-title":"Cancer Lett"},{"key":"5085_CR44","doi-asserted-by":"publisher","first-page":"5337","DOI":"10.1158\/1078-0432.CCR-15-2973","volume":"22","author":"F Geng","year":"2016","unstructured":"Geng F, Cheng X, Wu X, Yoo JY, Cheng C, Guo JY, Mo X, Ru P, Hurwitz B, Kim SH, Otero J, Puduvalli V, Lefai E, Ma J, Nakano I, Horbinski C, Kaur B, Chakravarti A, Guo D (2016) Inhibition of SOAT1 suppresses glioblastoma growth via blocking SREBP-1-mediated lipogenesis. Clin Cancer Res 22:5337\u20135348. https:\/\/doi.org\/10.1158\/1078-0432.CCR-15-2973","journal-title":"Clin Cancer Res"},{"key":"5085_CR45","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1186\/s13046-019-1288-7","volume":"38","author":"C Zhou","year":"2019","unstructured":"Zhou C, Qian W, Li J, Ma J, Chen X, Jiang Z, Cheng L, Duan W, Wang Z, Wu Z, Ma Q, Li X (2019) High glucose microenvironment accelerates tumor growth via SREBP1-autophagy axis in pancreatic cancer. J Exp Clin Cancer Res 38:302. https:\/\/doi.org\/10.1186\/s13046-019-1288-7","journal-title":"J Exp Clin Cancer Res"},{"key":"5085_CR46","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/s42255-022-00568-y","volume":"4","author":"C Cheng","year":"2022","unstructured":"Cheng C, Geng F, Li Z, Zhong Y, Wang H, Cheng X, Zhao Y, Mo X, Horbinski C, Duan W, Chakravarti A, Cheng X, Guo D (2022) Ammonia stimulates SCAP\/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth. Nat Metab 4:575\u2013588. https:\/\/doi.org\/10.1038\/s42255-022-00568-y","journal-title":"Nat Metab"},{"key":"5085_CR47","doi-asserted-by":"publisher","first-page":"4696","DOI":"10.1158\/0008-5472.CAN-15-1734","volume":"76","author":"Y Zhao","year":"2016","unstructured":"Zhao Y, Li H, Zhang Y, Li L, Fang R, Li Y, Liu Q, Zhang W, Qiu L, Liu F, Zhang X, Ye L (2016) Oncoprotein HBXIP modulates abnormal lipid metabolism and growth of breast cancer cells by activating the LXRs\/SREBP-1c\/FAS signaling cascade. Cancer Res 76:4696\u20134707. https:\/\/doi.org\/10.1158\/0008-5472.CAN-15-1734","journal-title":"Cancer Res"},{"key":"5085_CR48","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.1136\/gutjnl-2014-308430","volume":"65","author":"H Wu","year":"2016","unstructured":"Wu H, Ng R, Chen X, Steer CJ, Song G (2016) MicroRNA-21 is a potential link between non-alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1-p53-Srebp1c pathway. Gut 65:1850\u20131860. https:\/\/doi.org\/10.1136\/gutjnl-2014-308430","journal-title":"Gut"},{"key":"5085_CR49","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00265-17","author":"JH Lee","year":"2017","unstructured":"Lee JH, Jeon YG, Lee KH, Lee HW, Park J, Jang H, Kang M, Lee HS, Cho HJ, Nam DH, Kwak C, Kim JB (2017) RNF20 suppresses tumorigenesis by inhibiting the SREBP1c-PTTG1 axis in kidney cancer. Mol Cell Biol. https:\/\/doi.org\/10.1128\/MCB.00265-17","journal-title":"Mol Cell Biol"},{"key":"5085_CR50","doi-asserted-by":"publisher","unstructured":"Sethi G, Shanmugam MK, Kumar AP (2017) SREBP-1c as a molecular bridge between lipogenesis and cell cycle progression of clear cell renal carcinoma. Biosci Rep. https:\/\/doi.org\/10.1042\/BSR20171270","DOI":"10.1042\/BSR20171270"},{"key":"5085_CR51","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14194876","author":"E Teveroni","year":"2022","unstructured":"Teveroni E, Di Nicuolo F, Vergani E, Bianchetti G, Bruno C, Maulucci G, De Spirito M, Cenci T, Pierconti F, Gulino G, Bassi P, Pontecorvi A, Milardi D, Mancini F (2022) PTTG1\/ZEB1 axis regulates E-cadherin expression in human seminoma. Cancers (Basel). https:\/\/doi.org\/10.3390\/cancers14194876","journal-title":"Cancers (Basel)"},{"key":"5085_CR52","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/nrm.2017.95","volume":"19","author":"S Herzig","year":"2018","unstructured":"Herzig S, Shaw RJ (2018) AMPK: guardian of metabolism and mitochondrial homeostasis. Nat Rev Mol Cell Biol 19:121\u2013135. https:\/\/doi.org\/10.1038\/nrm.2017.95","journal-title":"Nat Rev Mol Cell Biol"},{"key":"5085_CR53","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/nrc2676","volume":"9","author":"DB Shackelford","year":"2009","unstructured":"Shackelford DB, Shaw RJ (2009) The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat Rev Cancer 9:563\u2013575. https:\/\/doi.org\/10.1038\/nrc2676","journal-title":"Nat Rev Cancer"},{"key":"5085_CR54","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.cmet.2011.03.009","volume":"13","author":"Y Li","year":"2011","unstructured":"Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy JY, Gao B, Wierzbicki M, Verbeuren TJ, Shaw RJ, Cohen RA, Zang M (2011) AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab 13:376\u2013388. https:\/\/doi.org\/10.1016\/j.cmet.2011.03.009","journal-title":"Cell Metab"},{"key":"5085_CR55","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/s41467-019-08585-4","volume":"10","author":"Y Han","year":"2019","unstructured":"Han Y, Hu Z, Cui A, Liu Z, Ma F, Xue Y, Liu Y, Zhang F, Zhao Z, Yu Y, Gao J, Wei C, Li J, Fang J, Li J, Fan JG, Song BL, Li Y (2019) Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene. Nat Commun 10:623. https:\/\/doi.org\/10.1038\/s41467-019-08585-4","journal-title":"Nat Commun"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-024-05085-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-024-05085-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-024-05085-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T08:17:03Z","timestamp":1740039423000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-024-05085-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,21]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["5085"],"URL":"https:\/\/doi.org\/10.1007\/s11010-024-05085-y","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,21]]},"assertion":[{"value":"17 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}