{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T23:10:53Z","timestamp":1772320253078,"version":"3.50.1"},"reference-count":69,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Ministry of Science, Technological Development and Innovation of the Republic of Serbia","award":["Grant No. 175043, No. 200110\/00402, and No. 451-03-66\/2024-03\/200110"],"award-info":[{"award-number":["Grant No. 175043, No. 200110\/00402, and No. 451-03-66\/2024-03\/200110"]}]},{"name":"Ministry of Science, Technological Development and Innovation of the Republic of Serbia","award":["Grant No. 175043, No. 200110\/00402, and No. 451-03-66\/2024-03\/200110"],"award-info":[{"award-number":["Grant No. 175043, No. 200110\/00402, and No. 451-03-66\/2024-03\/200110"]}]},{"name":"Ministry of Science, Technological Development and Innovation of the Republic of Serbia","award":["Grant No. 175043, No. 200110\/00402, and No. 451-03-66\/2024-03\/200110"],"award-info":[{"award-number":["Grant No. 175043, No. 200110\/00402, and No. 451-03-66\/2024-03\/200110"]}]},{"name":"Ministry of Science, Technological Development and Innovation of the Republic of Serbia","award":["Grant No. 175043, No. 200110\/00402, and No. 451-03-66\/2024-03\/200110"],"award-info":[{"award-number":["Grant No. 175043, No. 200110\/00402, and No. 451-03-66\/2024-03\/200110"]}]},{"name":"Ministry of Science, Technological Development and Innovation of the Republic of Serbia","award":["Grant No. 175043, No. 200110\/00402, and No. 451-03-66\/2024-03\/200110"],"award-info":[{"award-number":["Grant No. 175043, No. 200110\/00402, and No. 451-03-66\/2024-03\/200110"]}]},{"name":"Ministry of Science, Technological Development and Innovation of the Republic of Serbia","award":["Grant No. 175043, No. 200110\/00402, and No. 451-03-66\/2024-03\/200110"],"award-info":[{"award-number":["Grant No. 175043, No. 200110\/00402, and No. 451-03-66\/2024-03\/200110"]}]},{"name":"Ministry of Science, Technological Development and Innovation of the Republic of Serbia","award":["Grant No. 175043, No. 200110\/00402, and No. 451-03-66\/2024-03\/200110"],"award-info":[{"award-number":["Grant No. 175043, No. 200110\/00402, and No. 451-03-66\/2024-03\/200110"]}]},{"name":"Ministry of Science, Technological Development and Innovation of the Republic of Serbia","award":["Grant No. 175043, No. 200110\/00402, and No. 451-03-66\/2024-03\/200110"],"award-info":[{"award-number":["Grant No. 175043, No. 200110\/00402, and No. 451-03-66\/2024-03\/200110"]}]},{"name":"Ministry of Science, Technological Development and Innovation of the Republic of Serbia","award":["Grant No. 175043, No. 200110\/00402, and No. 451-03-66\/2024-03\/200110"],"award-info":[{"award-number":["Grant No. 175043, No. 200110\/00402, and No. 451-03-66\/2024-03\/200110"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s11010-024-05133-7","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T23:02:13Z","timestamp":1728514933000},"page":"2511-2524","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of four-week lasting aerobic treadmill training on hepatic injury biomarkers, oxidative stress parameters, metabolic enzymes activities and histological characteristics in liver tissue of hyperhomocysteinemic rats"],"prefix":"10.1007","volume":"480","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8270-3089","authenticated-orcid":false,"given":"Du\u0161an","family":"Todorovi\u0107","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6927-2715","authenticated-orcid":false,"given":"Marija","family":"Stojanovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2886-7058","authenticated-orcid":false,"given":"Slavica","family":"Mutavd\u017ein Krneta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4386-5907","authenticated-orcid":false,"given":"Jovana","family":"Jakovljevi\u0107 Uzelac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4045-6734","authenticated-orcid":false,"given":"Kristina","family":"Gop\u010devi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9919-2281","authenticated-orcid":false,"given":"Ana","family":"Medi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1471-0014","authenticated-orcid":false,"given":"Milica","family":"Labudovi\u0107 Borovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0890-535X","authenticated-orcid":false,"given":"Sanja","family":"Stankovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2196-9438","authenticated-orcid":false,"given":"Dragan M.","family":"Djuric","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"issue":"6 Suppl","key":"5133_CR1","doi-asserted-by":"publisher","first-page":"1636S","DOI":"10.1093\/jn\/136.6.1636S","volume":"136","author":"JT Brosnan","year":"2006","unstructured":"Brosnan JT, Brosnan ME (2006) The sulfur-containing amino acids: an overview. J Nutr 136(6 Suppl):1636S-1640S. https:\/\/doi.org\/10.1093\/jn\/136.6.1636S","journal-title":"J Nutr"},{"issue":"1","key":"5133_CR2","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1152\/physrev.00003.2018","volume":"99","author":"H Jakubowski","year":"2019","unstructured":"Jakubowski H (2019) Homocysteine modification in protein structure\/function and human disease. Physiol Rev 99(1):555\u2013604. https:\/\/doi.org\/10.1152\/physrev.00003.2018","journal-title":"Physiol Rev"},{"issue":"1","key":"5133_CR3","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/s41392-020-00349-7","volume":"5","author":"Z Li","year":"2020","unstructured":"Li Z, Wang F, Liang B, Su Y, Sun S, Xia S, Shao J, Zhang Z, Hong M, Zhang F, Zheng S (2020) Methionine metabolism in chronic liver diseases: an update on molecular mechanism and therapeutic implication. Sig Transduct Target Ther 5(1):280. https:\/\/doi.org\/10.1038\/s41392-020-00349-7","journal-title":"Sig Transduct Target Ther"},{"key":"5133_CR4","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1097\/MCO.0b013e32835a892a","volume":"16","author":"KK Kharbanda","year":"2013","unstructured":"Kharbanda KK (2013) Methionine metabolic pathway in alcoholic liver injury. Curr Opin Clin Nutr Metab Care 16:89\u201395. https:\/\/doi.org\/10.1097\/MCO.0b013e32835a892a","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"4","key":"5133_CR5","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1111\/acer.12315","volume":"38","author":"WH Watson","year":"2014","unstructured":"Watson WH, Burke TJ, Doll MA, McClain CJ (2014) S-adenosylhomocysteine inhibits NF-\u03baB-mediated gene expression in hepatocytes and confers sensitivity to TNF cytotoxicity. Alcohol Clin Exp Res 38(4):889\u2013896. https:\/\/doi.org\/10.1111\/acer.12315","journal-title":"Alcohol Clin Exp Res"},{"key":"5133_CR6","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1016\/j.bbadis.2013.05.013","volume":"1832","author":"R Esse","year":"2013","unstructured":"Esse R, Florindo C, Imbard A, Rocha MS, de Vriese AS, Smulders YM, Teerlink T, Tavares de Almeida I, Castro R, Blom HJ (2013) Global protein and histone arginine methylation are affected in a tissue-specific manner in a rat model of diet-induced hyperhomocysteinemia. Biochim Biophys Acta 1832:1708\u20131714. https:\/\/doi.org\/10.1016\/j.bbadis.2013.05.013","journal-title":"Biochim Biophys Acta"},{"issue":"11","key":"5133_CR7","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1111\/acer.13214","volume":"40","author":"M Ganesan","year":"2016","unstructured":"Ganesan M, Feng D, Barton RW, Thomes PG, McVicker BL, Tuma DJ, Osna NA, Kharbanda KK (2016) Creatine supplementation does not prevent the development of alcoholic steatosis. Alcohol Clin Exp Res 40(11):2312\u20132319. https:\/\/doi.org\/10.1111\/acer.13214","journal-title":"Alcohol Clin Exp Res"},{"issue":"6","key":"5133_CR8","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1111\/acer.13382","volume":"41","author":"J Auta","year":"2017","unstructured":"Auta J, Zhang H, Pandey SC, Guidotti A (2017) Chronic alcohol exposure differentially alters one-carbon metabolism in rat liver and brain. Alcohol Clin Exp Res 41(6):1105\u20131111. https:\/\/doi.org\/10.1111\/acer.13382","journal-title":"Alcohol Clin Exp Res"},{"issue":"3","key":"5133_CR9","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1515\/cclm-2012-0308","volume":"51","author":"CH Halsted","year":"2013","unstructured":"Halsted CH (2013) B-Vitamin dependent methionine metabolism and alcoholic liver disease. Clin Chem Lab Med 51(3):457\u2013465. https:\/\/doi.org\/10.1515\/cclm-2012-0308","journal-title":"Clin Chem Lab Med"},{"issue":"10","key":"5133_CR10","doi-asserted-by":"publisher","first-page":"e3152","DOI":"10.1038\/cddis.2017.532","volume":"8","author":"F Hao","year":"2017","unstructured":"Hao F, Cubero FJ, Ramadori P, Liao L, Haas U, Lambertz D, Sonntag R, Bangen JM, Gassler N, Hoss M, Streetz KL, Reissing J, Zimmermann HW, Trautwein C, Liedtke C, Nevzorova YA (2017) Inhibition of caspase-8 does not protect from alcohol-induced liver apoptosis but alleviates alcoholic hepatic steatosis in mice. Cell Death Dis 8(10):e3152. https:\/\/doi.org\/10.1038\/cddis.2017.532","journal-title":"Cell Death Dis"},{"key":"5133_CR11","doi-asserted-by":"publisher","first-page":"4134053","DOI":"10.1155\/2016\/4134053","volume":"2016","author":"T Guo","year":"2016","unstructured":"Guo T, He Y, Ma W, Liu Z, Liu Q (2016) Feasibility and efficacy of S-adenosyl-L-methionine in patients with HBV-related HCC with different BCLC stages. Gastroenterol Res Pract 2016:4134053. https:\/\/doi.org\/10.1155\/2016\/4134053","journal-title":"Gastroenterol Res Pract"},{"issue":"2","key":"5133_CR12","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1097\/shk.0b013e318160f417","volume":"30","author":"A Karaa","year":"2008","unstructured":"Karaa A, Thompson KJ, McKillop IH, Clemens MG, Schrum LW (2008) S-adenosyl-L-methionine attenuates oxidative stress and hepatic stellate cell activation in an ethanol-LPS-induced fibrotic rat model. Shock 30(2):197\u2013205. https:\/\/doi.org\/10.1097\/shk.0b013e318160f417","journal-title":"Shock"},{"issue":"6","key":"5133_CR13","doi-asserted-by":"publisher","first-page":"296","DOI":"10.3390\/medicina55060296","volume":"55","author":"RM Pascale","year":"2019","unstructured":"Pascale RM, Peitta G, Simile MM, Feo F (2019) Alterations of methionine metabolism as potential targets for the prevention and therapy of hepatocellular carcinoma. Medicina (Kaunas) 55(6):296. https:\/\/doi.org\/10.3390\/medicina55060296","journal-title":"Medicina (Kaunas)"},{"issue":"10","key":"5133_CR14","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1515\/cclm-2015-1040","volume":"54","author":"B Maroto-S\u00e1nchez","year":"2016","unstructured":"Maroto-S\u00e1nchez B, Lopez-Torres O, Palacios G, Gonz\u00e1lez-Gross M (2016) What do we know about homocysteine and exercise? A review from the literature. Clin Chem Lab Med 54(10):1561\u20131577. https:\/\/doi.org\/10.1515\/cclm-2015-1040","journal-title":"Clin Chem Lab Med"},{"key":"5133_CR15","doi-asserted-by":"publisher","first-page":"325","DOI":"10.3305\/nh.2013.28.2.6300","volume":"28","author":"B Maroto-Sanchez","year":"2013","unstructured":"Maroto-Sanchez B, Valtuena J, Albers U, Benito PJ, GonzalezGross M (2013) Acute physical exercise increases homocysteine concentrations in young trained male subjects. Nutr Hosp 28:325\u2013332. https:\/\/doi.org\/10.3305\/nh.2013.28.2.6300","journal-title":"Nutr Hosp"},{"key":"5133_CR16","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1123\/ijsnem.16.4.341","volume":"16","author":"LM Joubert","year":"2006","unstructured":"Joubert LM, Manore MM (2006) Exercise, nutrition, and homocysteine. Int J Sport Nutr Exer Metab 16:341\u2013361. https:\/\/doi.org\/10.1123\/ijsnem.16.4.341","journal-title":"Int J Sport Nutr Exer Metab"},{"key":"5133_CR17","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1159\/000070032","volume":"47","author":"D Konig","year":"2003","unstructured":"Konig D, Bisse E, Deibert P, Muller HM, Wieland H, Berg A (2003) Influence of training volume and acute physical exercise on the homocysteine levels in endurance-trained men: interactions with plasma folate and vitamin B12. Ann Nutr Metab 47:114\u2013118. https:\/\/doi.org\/10.1159\/000070032","journal-title":"Ann Nutr Metab"},{"issue":"11","key":"5133_CR18","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1515\/CCLM.2003.233","volume":"41","author":"M Herrmann","year":"2003","unstructured":"Herrmann M, Schorr H, Obeid R, Scharhag J, Urhausen A, Kindermann W, Herrmann W (2003) Homocysteine increases during endurance exercise. Clin Chem Lab Med 41(11):1518\u20131524. https:\/\/doi.org\/10.1515\/CCLM.2003.233","journal-title":"Clin Chem Lab Med"},{"issue":"12","key":"5133_CR19","doi-asserted-by":"publisher","first-page":"e51185","DOI":"10.1371\/journal.pone.0051185","volume":"7","author":"E Iglesias-Guti\u00e9rrez","year":"2012","unstructured":"Iglesias-Guti\u00e9rrez E, Egan B, D\u00edaz-Mart\u00ednez \u00c1E, Pe\u00f1alvo JL, Gonz\u00e1lez-Medina A, Mart\u00ednez-Camblor P, O\u2019Gorman DJ, \u00dabeda N (2012) Transient increase in homocysteine but not hyperhomocysteinemia during acute exercise at different intensities in sedentary individuals. PLoS ONE 7(12):e51185. https:\/\/doi.org\/10.1371\/journal.pone.0051185","journal-title":"PLoS ONE"},{"key":"5133_CR20","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1249\/MSS.0b013e31819e02f2","volume":"41","author":"R Venta","year":"2009","unstructured":"Venta R, Cruz E, Valcarcel G, Terrados N (2009) Plasma vitamins, amino acids, and renal function in postexercise hyperhomocysteinemia. Med Sci Sports Exerc 41:1645\u20131651. https:\/\/doi.org\/10.1249\/MSS.0b013e31819e02f2","journal-title":"Med Sci Sports Exerc"},{"key":"5133_CR21","doi-asserted-by":"publisher","first-page":"202","DOI":"10.4077\/CJP.2012.AMM122","volume":"55","author":"NA Guzel","year":"2012","unstructured":"Guzel NA, Pinar L, Colakoglu F, Karacan S, Ozer C (2012) Long-term callisthenic exercise-related changes in blood lipids, homocysteine, nitric oxide levels and body composition in middle-aged healthy sedentary women. Chin J Physiol 55:202\u2013209. https:\/\/doi.org\/10.4077\/CJP.2012.AMM122","journal-title":"Chin J Physiol"},{"issue":"1","key":"5133_CR22","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1550-2783-10-10","volume":"10","author":"J Molina-L\u00f3pez","year":"2013","unstructured":"Molina-L\u00f3pez J, Molina JM, Chirosa LJ, Florea DI, S\u00e1ez L, Planells E (2013) Effect of folic acid supplementation on homocysteine concentration and association with training in handball players. J Int Soc Sports Nutr 10(1):10. https:\/\/doi.org\/10.1186\/1550-2783-10-10","journal-title":"J Int Soc Sports Nutr"},{"issue":"4","key":"5133_CR23","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1007\/s00421-006-0294-6","volume":"98","author":"T Okura","year":"2006","unstructured":"Okura T, Rankinen T, Gagnon J, Lussier-Cacan S, Davignon J, Leon AS, Rao DC, Skinner JS, Wilmore JH, Bouchard C (2006) Effect of regular exercise on homocysteine concentrations: the HERITAGE Family Study. Eur J Appl Physiol 98(4):394\u2013401. https:\/\/doi.org\/10.1007\/s00421-006-0294-6","journal-title":"Eur J Appl Physiol"},{"key":"5133_CR24","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1136\/bjsm.2002.001131","volume":"39","author":"CA Boreham","year":"2005","unstructured":"Boreham CA, Kennedy RA, Murphy MH, Tully M, Wallace WF, Young I (2005) Training effects of short bouts of stair climbing on cardiorespiratory fitness, blood lipids, and homocysteine in sedentary young women. Br J Sports Med 39:590\u2013593. https:\/\/doi.org\/10.1136\/bjsm.2002.001131","journal-title":"Br J Sports Med"},{"key":"5133_CR25","doi-asserted-by":"publisher","first-page":"S61","DOI":"10.4149\/gpb_2011_SI1_61","volume":"30","author":"M Pavlikova","year":"2011","unstructured":"Pavlikova M, Kovalska M, Tatarkova Z, Sivonova-Kmetova M, Kaplan P, Lehotsky J (2011) Response of secretory pathways Ca2+ ATPase gene expression to hyperhomocysteinemia and\/or ischemic preconditioning in rat cerebral cortex and hippocampus. Gen Physiol Biophys 30:S61\u2013S69. https:\/\/doi.org\/10.4149\/gpb_2011_SI1_61","journal-title":"Gen Physiol Biophys"},{"key":"5133_CR26","first-page":"29","volume":"8","author":"FDB Manchado","year":"2005","unstructured":"Manchado FDB, Gobatto CA, Mello MARD (2005) The maximal lactate steady state in running rats. J Exerc Physiol Online 8:29\u201335","journal-title":"J Exerc Physiol Online"},{"key":"5133_CR27","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/S1388-9842(99)00048-3","volume":"1","author":"P Rouet-Benzineb","year":"1999","unstructured":"Rouet-Benzineb P, Buhler JM, Dreyfus P, Delcourt A, Dorent R, Perennec J, Crozatier B, Harf A, Lafuma C (1999) Altered balance between matrix gelatinases (MMP-2 and MMP-9) and their tissue inhibitors in human dilated cardiomyopathy: potential role of MMP-9 in myosin-heavy chain degradation. Eur J Heart Fail 1:337\u2013352. https:\/\/doi.org\/10.1016\/S1388-9842(99)00048-3","journal-title":"Eur J Heart Fail"},{"key":"5133_CR28","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254. https:\/\/doi.org\/10.1016\/0003-2697(76)90527-3","journal-title":"Anal Biochem"},{"key":"5133_CR29","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/S0021-9258(19)50881-X","volume":"195","author":"RF Beers Jr","year":"1952","unstructured":"Beers RF Jr, Sizer IW (1952) A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem 195:133\u2013140. https:\/\/doi.org\/10.1016\/S0021-9258(19)50881-X","journal-title":"J Biol Chem"},{"key":"5133_CR30","doi-asserted-by":"publisher","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","volume":"247","author":"HP Misra","year":"1972","unstructured":"Misra HP, Fridovich I (1972) The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 247:3170\u20133175. https:\/\/doi.org\/10.1016\/S0021-9258(19)45228-9","journal-title":"J Biol Chem"},{"key":"5133_CR31","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351\u2013358. https:\/\/doi.org\/10.1016\/0003-2697(79)90738-3","journal-title":"Anal Biochem"},{"key":"5133_CR32","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/0009-8981(79)90036-6","volume":"99","author":"L Hollaar","year":"1979","unstructured":"Hollaar L, Van der Laarse A (1979) Interference of the measurement of lactate dehydrogenase (LDH) activity in human serum and plasma by LDH from blood cells. Clin Chim Acta 99:135\u2013142. https:\/\/doi.org\/10.1016\/0009-8981(79)90036-6","journal-title":"Clin Chim Acta"},{"key":"5133_CR33","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1016\/S0021-9258(19)41689-X","volume":"250","author":"C Frieden","year":"1975","unstructured":"Frieden C, Fernandez-Sousa J (1975) Kinetic studies on pig heart cytoplasmic malate dehydrogenase. J Biol Chem 250:2106\u20132113. https:\/\/doi.org\/10.1016\/S0021-9258(19)41689-X","journal-title":"J Biol Chem"},{"key":"5133_CR34","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1136\/jcp.18.6.765","volume":"18","author":"VR Cunningham","year":"1965","unstructured":"Cunningham VR, Phillips J, Field EJ (1965) Lactic dehydrogenase isoenzymes in normal and pathological spinal fluids. J Clin Pathol 18:765\u2013770. https:\/\/doi.org\/10.1136\/jcp.18.6.765","journal-title":"J Clin Pathol"},{"key":"5133_CR35","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/BF00277461","volume":"22","author":"Y Yoshimura","year":"1970","unstructured":"Yoshimura Y, Kawano T, Kuroi M, Morishita M, Mori M, Kawakatsu K (1970) Zymographic demonstration of lactate and malate dehydrogenases isoenzymes in the rodent salivary glands. Histochemie 22:337\u2013346. https:\/\/doi.org\/10.1007\/BF00277461","journal-title":"Histochemie"},{"issue":"8","key":"5133_CR36","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/j.biochi.2009.04.018","volume":"91","author":"FM Stefanello","year":"2009","unstructured":"Stefanello FM, Matt\u00e9 C, Pederzolli CD, Kolling J, Mescka CP, Lamers ML, de Assis AM, Perry ML, dos Santos MF, Dutra-Filho CS, Wyse AT (2009) Hypermethioninemia provokes oxidative injury and histological changes in liver of rats. Biochimie 91(8):961\u2013968. https:\/\/doi.org\/10.1016\/j.biochi.2009.04.018","journal-title":"Biochimie"},{"issue":"1","key":"5133_CR37","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1111\/j.1478-3231.2005.01042.x","volume":"25","author":"P Ventura","year":"2005","unstructured":"Ventura P, Rosa MC, Abbati G, Marchini S, Grandone E, Vergura P, Tremosini S, Zeneroli ML (2005) Hyperhomocysteinaemia in chronic liver diseases: role of disease stage, vitamin status and methylenetetrahydrofolate reductase genetics. Liver Int 25(1):49\u201356. https:\/\/doi.org\/10.1111\/j.1478-3231.2005.01042.x","journal-title":"Liver Int"},{"issue":"2","key":"5133_CR38","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.carpath.2005.11.001","volume":"15","author":"S Devi","year":"2006","unstructured":"Devi S, Kennedy RH, Joseph L, Shekhawat NS, Melchert RB, Joseph J (2006) Effect of long-term hyperhomocysteinemia on myocardial structure and function in hypertensive rats. Cardiovasc Pathol 15(2):75\u201382. https:\/\/doi.org\/10.1016\/j.carpath.2005.11.001","journal-title":"Cardiovasc Pathol"},{"issue":"1\u20132","key":"5133_CR39","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s11010-017-3155-1","volume":"440","author":"M Stojanovi\u0107","year":"2018","unstructured":"Stojanovi\u0107 M, \u0160\u0107epanovi\u0107 L, Todorovi\u0107 D, Mitrovi\u0107 D, \u0160\u0107epanovi\u0107 V, \u0160\u0107epanovi\u0107 R, Ili\u0107 S, \u0160\u0107epanovi\u0107 T, Borovi\u0107 ML, Mili\u0107evi\u0107 \u017d, Dragutinovi\u0107 V, Borozan S, Lali\u0107 I, Despotovi\u0107 S, Djuric D (2018) Suppression of methionine-induced colon injury of young rats by cysteine and N-acetyl-L-cysteine. Mol Cell Biochem 440(1\u20132):53\u201364. https:\/\/doi.org\/10.1007\/s11010-017-3155-1","journal-title":"Mol Cell Biochem"},{"issue":"9","key":"5133_CR40","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1093\/ecco-jcc\/jjv094","volume":"9","author":"S Zhu","year":"2015","unstructured":"Zhu S, Li J, Bing Y, Yan W, Zhu Y, Xia B, Chen M (2015) Diet-induced hyperhomocysteinaemia increases intestinal inflammation in an animal model of colitis. J Crohns Colitis 9(9):708\u2013719. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjv094","journal-title":"J Crohns Colitis"},{"issue":"7","key":"5133_CR41","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.bbadis.2006.05.012","volume":"1762","author":"CW Woo","year":"2006","unstructured":"Woo CW, Prathapasinghe GA, Siow YL, Karmin O (2006) Hyperhomocysteinemia induces liver injury in rat: protective effect of folic acid supplementation. Biochim Biophys Acta 1762(7):656\u2013665. https:\/\/doi.org\/10.1016\/j.bbadis.2006.05.012","journal-title":"Biochim Biophys Acta"},{"key":"5133_CR42","doi-asserted-by":"publisher","first-page":"25702","DOI":"10.3402\/fnr.v59.25702","volume":"59","author":"CC Hsu","year":"2015","unstructured":"Hsu CC, Cheng CH, Hsu CL, Lee WJ, Huang SC, Huang YC (2015) Role of vitamin B6 status on antioxidant defenses, glutathione, and related enzyme activities in mice with homocysteine-induced oxidative stress. Food Nutr Res 59:25702. https:\/\/doi.org\/10.3402\/fnr.v59.25702","journal-title":"Food Nutr Res"},{"key":"5133_CR43","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.autneu.2013.10.006","volume":"180","author":"RH Mendes","year":"2014","unstructured":"Mendes RH, Mostarda C, Candido GO, Moraes-Silva IC, D\u2019Almeida V, Bell\u00f3-Klein A, Irigoyen MC, Rigatto K (2014) Moderate hyperhomocysteinemia provokes dysfunction of cardiovascular autonomic system and liver oxidative stress in rats. Auton Neurosci 180:43\u201347. https:\/\/doi.org\/10.1016\/j.autneu.2013.10.006","journal-title":"Auton Neurosci"},{"issue":"4","key":"5133_CR44","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.ijdevneu.2009.03.005","volume":"27","author":"C Matt\u00e9","year":"2009","unstructured":"Matt\u00e9 C, Stefanello FM, Mackedanz V, Pederzolli CD, Lamers ML, Dutra-Filho CS, Dos Santos MF, Wyse AT (2009) Homocysteine induces oxidative stress, inflammatory infiltration, fibrosis and reduces glycogen\/glycoprotein content in liver of rats. Int J Dev Neurosci 27(4):337\u2013344. https:\/\/doi.org\/10.1016\/j.ijdevneu.2009.03.005","journal-title":"Int J Dev Neurosci"},{"issue":"5","key":"5133_CR45","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1053\/j.gastro.2005.02.034","volume":"128","author":"K Robert","year":"2005","unstructured":"Robert K, Nehm\u00e9 J, Bourdon E, Pivert G, Friguet B, Delcayre C, Delabar JM, Janel N (2005) Cystathionine beta synthase deficiency promotes oxidative stress, fibrosis, and steatosis in mice liver. Gastroenterology 128(5):1405\u20131415. https:\/\/doi.org\/10.1053\/j.gastro.2005.02.034","journal-title":"Gastroenterology"},{"issue":"4","key":"5133_CR46","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/s0049-3848(97)00145-x","volume":"87","author":"TB Domagala","year":"1997","unstructured":"Domagala TB, Libura M, Szczeklik A (1997) Hyperhomocysteinemia following oral methionine load is associated with increased lipid peroxidation. Thromb Res 87(4):411\u2013416. https:\/\/doi.org\/10.1016\/s0049-3848(97)00145-x","journal-title":"Thromb Res"},{"issue":"13","key":"5133_CR47","doi-asserted-by":"publisher","first-page":"6792","DOI":"10.3390\/ijms22136792","volume":"22","author":"D Todorovic","year":"2021","unstructured":"Todorovic D, Stojanovic M, Medic A, Gopcevic K, Mutavdzin S, Stankovic S, Djuric D (2021) Four weeks of aerobic training affects cardiac tissue matrix metalloproteinase, lactate dehydrogenase and malate dehydrogenase enzymes activities, and hepatorenal biomarkers in experimental hyperhomocysteinemia in rats. Int J Mol Sci 22(13):6792. https:\/\/doi.org\/10.3390\/ijms22136792","journal-title":"Int J Mol Sci"},{"issue":"4","key":"5133_CR48","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.3390\/ijms25041946","volume":"25","author":"M Stojanovi\u0107","year":"2024","unstructured":"Stojanovi\u0107 M, Todorovi\u0107 D, Gop\u010devi\u0107 K, Medi\u0107 A, Labudovi\u0107 Borovi\u0107 M, Despotovi\u0107 S, Djuric D (2024) Effects of aerobic treadmill training on oxidative stress parameters, metabolic enzymes, and histomorphometric changes in colon of rats with experimentally induced hyperhomocysteinemia. Int J Mol Sci 25(4):1946. https:\/\/doi.org\/10.3390\/ijms25041946","journal-title":"Int J Mol Sci"},{"issue":"7","key":"5133_CR49","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1002\/cbf.2938","volume":"31","author":"J Kolling","year":"2013","unstructured":"Kolling J, Scherer EB, Siebert C, Hansen F, Torres FV, Scaini G, Ferreira G, de Andrade RB, Gon\u00e7alves CA, Streck EL, Wannmacher CM, Wyse AT (2013) Homocysteine induces energy imbalance in rat skeletal muscle: is creatine a protector? Cell Biochem Funct 31(7):575\u2013584. https:\/\/doi.org\/10.1002\/cbf.2938","journal-title":"Cell Biochem Funct"},{"key":"5133_CR50","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1152\/physrev.2000.80.3.1107","volume":"80","author":"M Wyss","year":"2000","unstructured":"Wyss M, Kaddurah-Daouk R (2000) Creatine and creatinine metabolism. Physiol Ver 80:1107\u20131213. https:\/\/doi.org\/10.1152\/physrev.2000.80.3.1107","journal-title":"Physiol Ver"},{"key":"5133_CR51","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.advenzreg.2003.11.012","volume":"44","author":"LM Stead","year":"2004","unstructured":"Stead LM, Jacobs RL, Brosnan ME, Brosnan JT (2004) Methylation demand and homocysteine metabolism. Adv Enzyme Regul 44:321\u2013333. https:\/\/doi.org\/10.1016\/j.advenzreg.2003.11.012","journal-title":"Adv Enzyme Regul"},{"key":"5133_CR52","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1046\/j.1523-1755.2003.00206.x","volume":"64","author":"YE Taes","year":"2003","unstructured":"Taes YE, Delanghe JR, De Vriese AS, Rombaut R, Vam Camp RJ, Lameire NH (2003) Creatine supplementation decrease homocysteine in an animal model of uremia. Kidney Int 64:1331\u20131337. https:\/\/doi.org\/10.1046\/j.1523-1755.2003.00206.x","journal-title":"Kidney Int"},{"key":"5133_CR53","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1054\/mehy.1999.1014","volume":"56","author":"MF Mccarty","year":"2001","unstructured":"Mccarty MF (2001) Supplemental creatine may decrease serum homocysteine and abolish the homocysteine \u2018gender gap\u2019 by suppressing endogenous creatine synthesis. Med Hypotheses 56:5\u20137. https:\/\/doi.org\/10.1054\/mehy.1999.1014","journal-title":"Med Hypotheses"},{"key":"5133_CR54","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1002\/ana.20419","volume":"57","author":"OA Bodamer","year":"2005","unstructured":"Bodamer OA, Sahoo T, Beaudet AL, O\u2019Brien WE, Bottiglieri T, St\u00f6ckler-Ipsiroglu S, Wagner C, Scaglia F (2005) Creatine metabolism in combined methylmalonic aciduria and homocystinuria. Ann Neurol 57:557\u2013560. https:\/\/doi.org\/10.1002\/ana.20419","journal-title":"Ann Neurol"},{"key":"5133_CR55","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/S0026-895X(25)13037-X","volume":"32","author":"LH Lash","year":"1987","unstructured":"Lash LH, Anders MW (1987) Mechanism of S-(1,2-dichlorovinyl)-L-cysteine- and S-(1,2-dichlorovinyl)- L-homocysteine-induced renal mitochondrial toxicity. Mol Pharmacol 32:549\u2013556","journal-title":"Mol Pharmacol"},{"key":"5133_CR56","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1007\/s00726-007-0011-8","volume":"34","author":"L Chang","year":"2008","unstructured":"Chang L, Geng B, Zhao J, Jiang H, Tang C (2008) Hydrogen sulfide inhibits myocardial injury induced by homocysteine in rats. Amino Acids 34:573\u2013585. https:\/\/doi.org\/10.1007\/s00726-007-0011-8","journal-title":"Amino Acids"},{"key":"5133_CR57","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s11010-015-2588-7","volume":"411","author":"V Timkova","year":"2016","unstructured":"Timkova V, Tatarkova Z, Lehotsk\u00fd J, Racay P, Dobrota D, Kapl\u00e1n P (2016) Effects of mild hyperhomocysteinemia on electron transport chain complexes, oxidative stress, and protein expression in rat cardiac mitochondria. Mol Cell Biochem 411:261\u2013270. https:\/\/doi.org\/10.1007\/s11010-015-2588-7","journal-title":"Mol Cell Biochem"},{"key":"5133_CR58","doi-asserted-by":"publisher","first-page":"2036","DOI":"10.1093\/jn\/137.9.2036","volume":"137","author":"Y Chou","year":"2007","unstructured":"Chou Y, Huang S (2007) Changes in mitochondrial DNA deletion, content, and biogenesis in folate-deficient tissues of young rats depend on mitochondrial folate and oxidative DNA injuries. J Nutr 137:2036\u20132042. https:\/\/doi.org\/10.1093\/jn\/137.9.2036","journal-title":"J Nutr"},{"key":"5133_CR59","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1093\/ajcn\/57.1.47","volume":"57","author":"JB Ubbink","year":"1993","unstructured":"Ubbink JB, Vermaak WJ, van der Merwe A, Becker PJ (1993) Vitamin B12, vitamin B6, and folate nutritional status in men with hyperhomocysteinemia. Am J Clin Nutr 57:47\u201353. https:\/\/doi.org\/10.1093\/ajcn\/57.1.47","journal-title":"Am J Clin Nutr"},{"key":"5133_CR60","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/0021-9150(90)90058-q","volume":"81","author":"L Brattstrom","year":"1990","unstructured":"Brattstrom L, Israelsson B, Norrving B, Bergqvist D, Thorne J, Hultberg B, Hamfelt A (1990) Impaired homocysteine metabolism in early-onset cerebral and peripheral occlusive arterial disease. effects of pyridoxine and folic acid treatment. Atherosclerosis 81:51\u201360. https:\/\/doi.org\/10.1016\/0021-9150(90)90058-q","journal-title":"Atherosclerosis"},{"issue":"9","key":"5133_CR61","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.3724\/abbs.2022093","volume":"54","author":"S Ma","year":"2022","unstructured":"Ma S, Lu G, Zhang Q, Ding N, Jie Y, Zhang H, Xu L, Xie L, Yang X, Zhang H, Jiang Y (2022) Extracellular-superoxide dismutase DNA methylation promotes oxidative stress in homocysteine-induced atherosclerosis. Acta Biochim Biophys Sin (Shanghai) 54(9):1222\u20131233. https:\/\/doi.org\/10.3724\/abbs.2022093","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"5133_CR62","doi-asserted-by":"publisher","first-page":"5175","DOI":"10.2147\/IJGM.S329863","volume":"14","author":"D Lv","year":"2021","unstructured":"Lv D, Wang Z, Ji S, Wang X, Hou H (2021) Plasma levels of homocysteine is associated with liver fibrosis in health check-up population. Int J Gen Med 14:5175\u20135181. https:\/\/doi.org\/10.2147\/IJGM.S329863","journal-title":"Int J Gen Med"},{"issue":"12","key":"5133_CR63","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.3390\/nu16121872","volume":"16","author":"M Yang","year":"2024","unstructured":"Yang M, Wang D, Wang X, Mei J, Gong Q (2024) Role of folate in liver diseases. Nutrients 16(12):1872. https:\/\/doi.org\/10.3390\/nu16121872","journal-title":"Nutrients"},{"issue":"2","key":"5133_CR64","doi-asserted-by":"publisher","first-page":"197","DOI":"10.3233\/CBM-201545","volume":"29","author":"M Yang","year":"2020","unstructured":"Yang M, Tan W, Yang X, Zhuo J, Lin Z, Cen B, Lian Z, Li H, Lu D, Wei X, Zheng S, Xu X (2020) Homocysteine: a novel prognostic biomarker in liver transplantation for alpha-fetoprotein- negative hepatocellular carcinoma. Cancer Biomark 29(2):197\u2013206. https:\/\/doi.org\/10.3233\/CBM-201545","journal-title":"Cancer Biomark"},{"issue":"2","key":"5133_CR65","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1017\/S0007114520001890","volume":"125","author":"N Al-Bayyari","year":"2021","unstructured":"Al-Bayyari N, Hailat R, Subih H, Alkhalidy H, Eaton A (2021) Vitamin D3 reduces risk of cardiovascular and liver diseases by lowering homocysteine levels: double-blinded, randomised, placebo-controlled trial. Br J Nutr 125(2):139\u2013146. https:\/\/doi.org\/10.1017\/S0007114520001890","journal-title":"Br J Nutr"},{"issue":"1","key":"5133_CR66","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1007\/s11695-021-05701-6","volume":"32","author":"A Pastore","year":"2022","unstructured":"Pastore A, Panera N, Mosca A, Caccamo R, Camanni D, Crudele A, De Stefanis C, Alterio A, Di Giovamberardino G, De Vito R, Francalanci P, Battaglia S, Muda AO, De Peppo F, Alisi A (2022) Changes in total homocysteine and glutathione levels after laparoscopic sleeve gastrectomy in children with metabolic-associated fatty liver disease. Obes Surg 32(1):82\u201389. https:\/\/doi.org\/10.1007\/s11695-021-05701-6","journal-title":"Obes Surg"},{"issue":"1","key":"5133_CR67","doi-asserted-by":"publisher","first-page":"51","DOI":"10.15403\/jgld-529","volume":"29","author":"Y Xu","year":"2020","unstructured":"Xu Y, Guan Y, Yang X, Xia Z, Wu J (2020) Association of serum homocysteine levels with histological severity of NAFLD. J Gastrointestin Liver Dis 29(1):51\u201358. https:\/\/doi.org\/10.15403\/jgld-529","journal-title":"J Gastrointestin Liver Dis"},{"issue":"2","key":"5133_CR68","doi-asserted-by":"publisher","first-page":"e13216","DOI":"10.1016\/j.heliyon.2023.e13216","volume":"9","author":"M Warrier","year":"2023","unstructured":"Warrier M, Paules EM, Silva-Gomez J, Friday WB, Bramlett F, Kim H, Zhang K, Trujillo-Gonzalez I (2023) Homocysteine-induced endoplasmic reticulum stress activates FGF21 and is associated with browning and atrophy of white adipose tissue in Bhmt knockout mice. Heliyon 9(2):e13216. https:\/\/doi.org\/10.1016\/j.heliyon.2023.e13216","journal-title":"Heliyon"},{"issue":"1","key":"5133_CR69","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1179\/135100003125001260","volume":"8","author":"V Vitvitsky","year":"2003","unstructured":"Vitvitsky V, Mosharov E, Tritt M, Ataullakhanov F, Banerjee R (2003) Redox regulation of homocysteine-dependent glutathione synthesis. Redox Rep 8(1):57\u201363. https:\/\/doi.org\/10.1179\/135100003125001260","journal-title":"Redox Rep"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-024-05133-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-024-05133-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-024-05133-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T02:41:38Z","timestamp":1743734498000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-024-05133-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,10]]},"references-count":69,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["5133"],"URL":"https:\/\/doi.org\/10.1007\/s11010-024-05133-7","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,10]]},"assertion":[{"value":"19 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The study has been approved by the Ethical Council for the Welfare of Experimental Animals, Ministry of Agriculture, Forestry and Water Management, Veterinary Directorate, Republic of Serbia No: 323-07-02523\/2018-05.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}