{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:12:00Z","timestamp":1788973920297,"version":"build-2803163510"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,10,27]],"date-time":"2024-10-27T00:00:00Z","timestamp":1729987200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,27]],"date-time":"2024-10-27T00:00:00Z","timestamp":1729987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s11010-024-05144-4","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T08:53:42Z","timestamp":1730105622000},"page":"2131-2142","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Mitochondrial Dysfunction-Molecular Mechanisms and Potential Treatment approaches of Hepatocellular Carcinoma"],"prefix":"10.1007","volume":"480","author":[{"given":"Lianlin","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shasha","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kehui","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,27]]},"reference":[{"key":"5144_CR1","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.currproblcancer.2017.10.007","volume":"42","author":"HW Sim","year":"2018","unstructured":"Sim HW, Knox J (2018) Hepatocellular carcinoma in the era of immunotherapy. Curr Probl Cancer 42:40\u201348","journal-title":"Curr Probl Cancer"},{"key":"5144_CR2","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.cld.2022.08.004","volume":"27","author":"P Ganesan","year":"2023","unstructured":"Ganesan P, Kulik LM (2023) Hepatocellular carcinoma: new developments. Clin Liver Dis 27:85\u2013102","journal-title":"Clin Liver Dis"},{"key":"5144_CR3","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1038\/s12276-020-00527-1","volume":"52","author":"E Kim","year":"2020","unstructured":"Kim E, Viatour P (2020) Hepatocellular carcinoma: old friends and new tricks. Exp Mol Med 52:1898\u20131907","journal-title":"Exp Mol Med"},{"key":"5144_CR4","doi-asserted-by":"publisher","first-page":"6841","DOI":"10.3748\/wjg.v22.i30.6841","volume":"22","author":"N Kubo","year":"2016","unstructured":"Kubo N, Araki K, Kuwano H, Shirabe K (2016) Cancer-associated fibroblasts in hepatocellular carcinoma. World J Gastroenterol 22:6841\u20136850","journal-title":"World J Gastroenterol"},{"key":"5144_CR5","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/s41575-019-0186-y","volume":"16","author":"JD Yang","year":"2019","unstructured":"Yang JD, Hainaut P, Gores GJ, Amadou A, Plymoth A, Roberts LR (2019) A global view of hepatocellular carcinoma: trends, risk, prevention and management. Nat Rev Gastroenterol Hepatol 16:589\u2013604","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"5144_CR6","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1053\/j.semdp.2016.12.011","volume":"34","author":"J Hartke","year":"2017","unstructured":"Hartke J, Johnson M, Ghabril M (2017) The diagnosis and treatment of hepatocellular carcinoma. Semin Diagn Pathol 34:153\u2013159","journal-title":"Semin Diagn Pathol"},{"key":"5144_CR7","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.2217\/fon-2020-0758","volume":"17","author":"PR Galle","year":"2021","unstructured":"Galle PR, Dufour JF, Peck-Radosavljevic M, Trojan J, Vogel A (2021) Systemic therapy of advanced hepatocellular carcinoma. Future Oncol 17:1237\u20131251","journal-title":"Future Oncol"},{"key":"5144_CR8","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1136\/gutjnl-2019-320282","volume":"69","author":"J von Felden","year":"2020","unstructured":"von Felden J, Garcia-Lezana T, Schulze K, Losic B, Villanueva A (2020) Liquid biopsy in the clinical management of hepatocellular carcinoma. Gut 69:2025\u20132034","journal-title":"Gut"},{"key":"5144_CR9","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1007\/s11864-023-01098-9","volume":"24","author":"B Alawyia","year":"2023","unstructured":"Alawyia B, Constantinou C (2023) Hepatocellular carcinoma: a narrative review on current knowledge and future prospects. Curr Treat Options Oncol 24:711\u2013724","journal-title":"Curr Treat Options Oncol"},{"key":"5144_CR10","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1002\/cac2.12345","volume":"42","author":"K Cheng","year":"2022","unstructured":"Cheng K, Cai N, Zhu J, Yang X, Liang H, Zhang W (2022) Tumor-associated macrophages in liver cancer: From mechanisms to therapy. Cancer Commun (Lond) 42:1112\u20131140","journal-title":"Cancer Commun (Lond)"},{"key":"5144_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.803037","volume":"12","author":"C Wang","year":"2021","unstructured":"Wang C, Ma C, Gong L, Guo Y, Fu K, Zhang Y et al (2021) Macrophage polarization and its role in liver disease. Front Immunol 12:803037","journal-title":"Front Immunol"},{"key":"5144_CR12","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.tibs.2015.01.002","volume":"40","author":"D Senft","year":"2015","unstructured":"Senft D, Ronai ZA (2015) UPR, autophagy, and mitochondria crosstalk underlies the ER stress response. Trends Biochem Sci 40:141\u2013148","journal-title":"Trends Biochem Sci"},{"key":"5144_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2022.215912","volume":"549","author":"Q Wang","year":"2022","unstructured":"Wang Q, Yu P, Liu C, He X, Wang G (2022) Mitochondrial fragmentation in liver cancer: emerging player and promising therapeutic opportunities. Cancer Lett 549:215912","journal-title":"Cancer Lett"},{"key":"5144_CR14","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.cca.2020.02.024","volume":"506","author":"A Gao","year":"2020","unstructured":"Gao A, Jiang J, Xie F, Chen L (2020) Bnip3 in mitophagy: novel insights and potential therapeutic target for diseases of secondary mitochondrial dysfunction. Clin Chim Acta 506:72\u201383","journal-title":"Clin Chim Acta"},{"key":"5144_CR15","doi-asserted-by":"publisher","first-page":"1149809","DOI":"10.3389\/fphar.2023.1149809","volume":"14","author":"A Alim Al-Bari","year":"2023","unstructured":"Alim Al-Bari A, Ito Y, Thomes PG, Menon MB, Garc\u00eda-Macia M, Fadel R et al (2023) Emerging mechanistic insights of selective autophagy in hepatic diseases. Front Pharmacol 14:1149809","journal-title":"Front Pharmacol"},{"key":"5144_CR16","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.2741\/4169","volume":"18","author":"W Wang","year":"2013","unstructured":"Wang W, Sun Q, Wu Z, Zhou D, Wei J, Xie H et al (2013) Mitochondrial dysfunction-related genes in hepatocellular carcinoma. Front Biosci (Landmark Ed) 18:1141\u20131149","journal-title":"Front Biosci (Landmark Ed)"},{"issue":"8","key":"5144_CR17","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.3390\/cells10081901","volume":"10","author":"HY Lee","year":"2021","unstructured":"Lee HY, Nga HT, Tian J, Yi HS (2021) Mitochondrial metabolic signatures in hepatocellular carcinoma. Cells 10(8):1901","journal-title":"Cells"},{"key":"5144_CR18","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1177\/1535370219898141","volume":"245","author":"D Dhar","year":"2020","unstructured":"Dhar D, Baglieri J, Kisseleva T, Brenner DA (2020) Mechanisms of liver fibrosis and its role in liver cancer. Exp Biol Med (Maywood) 245:96\u2013108","journal-title":"Exp Biol Med (Maywood)"},{"key":"5144_CR19","doi-asserted-by":"publisher","first-page":"3156","DOI":"10.3390\/cimb44070218","volume":"44","author":"C Zhang","year":"2022","unstructured":"Zhang C, Zhao Y, Yu M, Qin J, Ye B, Wang Q (2022) Mitochondrial dysfunction and chronic liver disease. Curr Issues Mol Biol 44:3156\u20133165","journal-title":"Curr Issues Mol Biol"},{"key":"5144_CR20","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/j.cell.2012.02.035","volume":"148","author":"J Nunnari","year":"2012","unstructured":"Nunnari J, Suomalainen A (2012) Mitochondria: in sickness and in health. Cell 148:1145\u20131159","journal-title":"Cell"},{"key":"5144_CR21","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.freeradbiomed.2020.11.016","volume":"170","author":"JH Santos","year":"2021","unstructured":"Santos JH (2021) Mitochondria signaling to the epigenome: a novel role for an old organelle. Free Radic Biol Med 170:59\u201369","journal-title":"Free Radic Biol Med"},{"key":"5144_CR22","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1534\/genetics.117.300262","volume":"207","author":"AM van der Bliek","year":"2017","unstructured":"van der Bliek AM, Sedensky MM, Morgan PG (2017) Cell biology of the mitochondrion. Genetics 207:843\u2013871","journal-title":"Genetics"},{"key":"5144_CR23","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.tcb.2018.02.009","volume":"28","author":"G Csord\u00e1s","year":"2018","unstructured":"Csord\u00e1s G, Weaver D, Hajn\u00f3czky G (2018) Endoplasmic reticulum-mitochondrial contactology: structure and signaling functions. Trends Cell Biol 28:523\u2013540","journal-title":"Trends Cell Biol"},{"key":"5144_CR24","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1146\/annurev-biochem-060815-014343","volume":"85","author":"BJ Greber","year":"2016","unstructured":"Greber BJ, Ban N (2016) Structure and function of the mitochondrial ribosome. Annu Rev Biochem 85:103\u2013132","journal-title":"Annu Rev Biochem"},{"key":"5144_CR25","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.3390\/ijms18071576","volume":"18","author":"J Szyma\u0144ski","year":"2017","unstructured":"Szyma\u0144ski J, Janikiewicz J, Michalska B, Patalas-Krawczyk P, Perrone M, Zi\u00f3\u0142kowski W et al (2017) Interaction of mitochondria with the endoplasmic reticulum and plasma membrane in calcium homeostasis, lipid trafficking and mitochondrial structure. Int J Mol Sci 18:1576","journal-title":"Int J Mol Sci"},{"key":"5144_CR26","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s10456-020-09720-2","volume":"23","author":"J Wang","year":"2020","unstructured":"Wang J, Toan S, Zhou H (2020) New insights into the role of mitochondria in cardiac microvascular ischemia\/reperfusion injury. Angiogenesis 23:299\u2013314","journal-title":"Angiogenesis"},{"key":"5144_CR27","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1111\/bph.15068","volume":"178","author":"M Forte","year":"2021","unstructured":"Forte M, Schirone L, Ameri P, Basso C, Catalucci D, Modica J et al (2021) The role of mitochondrial dynamics in cardiovascular diseases. Br J Pharmacol 178:2060\u20132076","journal-title":"Br J Pharmacol"},{"key":"5144_CR28","doi-asserted-by":"publisher","first-page":"65001","DOI":"10.18632\/oncotarget.11339","volume":"7","author":"L Zhan","year":"2016","unstructured":"Zhan L, Cao H, Wang G, Lyu Y, Sun X, An J et al (2016) Drp1-mediated mitochondrial fission promotes cell proliferation through crosstalk of p53 and NF-\u03baB pathways in hepatocellular carcinoma. Oncotarget 7:65001\u201365011","journal-title":"Oncotarget"},{"key":"5144_CR29","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/s41416-019-0658-4","volume":"122","author":"Z Zhang","year":"2020","unstructured":"Zhang Z, Li TE, Chen M, Xu D, Zhu Y, Hu BY et al (2020) MFN1-dependent alteration of mitochondrial dynamics drives hepatocellular carcinoma metastasis by glucose metabolic reprogramming. Br J Cancer 122:209\u2013220","journal-title":"Br J Cancer"},{"key":"5144_CR30","doi-asserted-by":"publisher","first-page":"144","DOI":"10.3390\/ijms18010144","volume":"18","author":"C Hu","year":"2017","unstructured":"Hu C, Huang Y, Li L (2017) Drp1-dependent mitochondrial fission plays critical roles in physiological and pathological progresses in mammals. Int J Mol Sci 18:144","journal-title":"Int J Mol Sci"},{"key":"5144_CR31","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/labinvest.2012.144","volume":"93","author":"X Zhao","year":"2013","unstructured":"Zhao X, Tian C, Puszyk WM, Ogunwobi OO, Cao M, Wang T et al (2013) OPA1 downregulation is involved in sorafenib-induced apoptosis in hepatocellular carcinoma. Lab Invest 93:8\u201319","journal-title":"Lab Invest"},{"key":"5144_CR32","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1002\/jor.22320","volume":"31","author":"LA Nasto","year":"2013","unstructured":"Nasto LA, Robinson AR, Ngo K, Clauson CL, Dong Q, St Croix C et al (2013) Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration. J Orthop Res 31:1150\u20131157","journal-title":"J Orthop Res"},{"key":"5144_CR33","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/nrc3365","volume":"12","author":"DC Wallace","year":"2012","unstructured":"Wallace DC (2012) Mitochondria and cancer. Nat Rev Cancer 12:685\u2013698","journal-title":"Nat Rev Cancer"},{"key":"5144_CR34","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1080\/15384101.2015.1038685","volume":"14","author":"K Wang","year":"2015","unstructured":"Wang K (2015) Autophagy and apoptosis in liver injury. Cell Cycle 14:1631\u20131642","journal-title":"Cell Cycle"},{"key":"5144_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114711","volume":"162","author":"C Song","year":"2023","unstructured":"Song C, Zhou Y, Cheng K, Liu F, Cai W, Zhou D et al (2023) Cellular senescence\u2014Molecular mechanisms of intervertebral disc degeneration from an immune perspective. Biomed Pharmacother 162:114711","journal-title":"Biomed Pharmacother"},{"key":"5144_CR36","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.canlet.2008.10.048","volume":"286","author":"M Ozturk","year":"2009","unstructured":"Ozturk M, Arslan-Ergul A, Bagislar S, Senturk S, Yuzugullu H (2009) Senescence and immortality in hepatocellular carcinoma. Cancer Lett 286:103\u2013113","journal-title":"Cancer Lett"},{"key":"5144_CR37","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1172\/JCI64125","volume":"123","author":"A Bratic","year":"2013","unstructured":"Bratic A, Larsson NG (2013) The role of mitochondria in aging. J Clin Invest 123:951\u2013957","journal-title":"J Clin Invest"},{"key":"5144_CR38","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1055\/s-2007-991511","volume":"27","author":"G Szabo","year":"2007","unstructured":"Szabo G, Mandrekar P, Dolganiuc A (2007) Innate immune response and hepatic inflammation. Semin Liver Dis 27:339\u2013350","journal-title":"Semin Liver Dis"},{"key":"5144_CR39","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1159\/000343852","volume":"2","author":"G Ramakrishna","year":"2013","unstructured":"Ramakrishna G, Rastogi A, Trehanpati N, Sen B, Khosla R, Sarin SK (2013) From cirrhosis to hepatocellular carcinoma: new molecular insights on inflammation and cellular senescence. Liver Cancer 2:367\u2013383","journal-title":"Liver Cancer"},{"key":"5144_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101833","volume":"84","author":"Y He","year":"2023","unstructured":"He Y, Su Y, Duan C, Wang S, He W, Zhang Y et al (2023) Emerging role of aging in the progression of NAFLD to HCC. Ageing Res Rev 84:101833","journal-title":"Ageing Res Rev"},{"key":"5144_CR41","doi-asserted-by":"publisher","first-page":"2917","DOI":"10.1111\/liv.14659","volume":"40","author":"ND Karakousis","year":"2020","unstructured":"Karakousis ND, Papatheodoridi A, Chatzigeorgiou A, Papatheodoridis G (2020) Cellular senescence and hepatitis B-related hepatocellular carcinoma: an intriguing link. Liver Int 40:2917\u20132927","journal-title":"Liver Int"},{"key":"5144_CR42","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/s41575-021-00568-5","volume":"19","author":"D Geh","year":"2022","unstructured":"Geh D, Leslie J, Rumney R, Reeves HL, Bird TG, Mann DA (2022) Neutrophils as potential therapeutic targets in hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol 19:257\u2013273","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"5144_CR43","doi-asserted-by":"publisher","first-page":"3174","DOI":"10.1002\/hep.32062","volume":"74","author":"Q He","year":"2021","unstructured":"He Q, Liu M, Huang W, Chen X, Zhang B, Zhang T et al (2021) IL-1\u03b2-induced elevation of solute carrier family 7 member 11 promotes hepatocellular carcinoma metastasis through up-regulating programmed death ligand 1 and colony-stimulating factor 1. Hepatology 74:3174\u20133193","journal-title":"Hepatology"},{"key":"5144_CR44","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.3389\/fimmu.2019.01643","volume":"10","author":"Z Zong","year":"2019","unstructured":"Zong Z, Zou J, Mao R, Ma C, Li N, Wang J et al (2019) M1 Macrophages induce PD-L1 expression in hepatocellular carcinoma cells through IL-1\u03b2 signaling. Front Immunol 10:1643","journal-title":"Front Immunol"},{"key":"5144_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114560","volume":"161","author":"Z Gao","year":"2023","unstructured":"Gao Z, Feng SR, Chen JF, Li XG, Shi YH, Tang Z et al (2023) Inhibition of autophagy in macrophage promotes IL-1\u03b2-mediated hepatocellular carcinoma progression via inflammasome accumulation and self-recruitment. Biomed Pharmacother 161:114560","journal-title":"Biomed Pharmacother"},{"key":"5144_CR46","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1016\/j.apsb.2020.06.015","volume":"10","author":"X Zhang","year":"2020","unstructured":"Zhang X, Zhang P, An L, Sun N, Peng L, Tang W et al (2020) Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis. Acta Pharm Sin B 10:1397\u20131413","journal-title":"Acta Pharm Sin B"},{"key":"5144_CR47","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.845974","volume":"13","author":"Y Hu","year":"2022","unstructured":"Hu Y, Chen D, Hong M, Liu J, Li Y, Hao J et al (2022) Apoptosis, pyroptosis, and ferroptosis conspiringly induce immunosuppressive hepatocellular carcinoma microenvironment and \u03b3\u03b4 T-cell imbalance. Front Immunol 13:845974","journal-title":"Front Immunol"},{"key":"5144_CR48","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.748039","volume":"9","author":"XW Fu","year":"2021","unstructured":"Fu XW, Song CQ (2021) Identification and validation of pyroptosis-related gene signature to predict prognosis and reveal immune infiltration in hepatocellular carcinoma. Front Cell Dev Biol 9:748039","journal-title":"Front Cell Dev Biol"},{"key":"5144_CR49","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s40659-019-0242-7","volume":"52","author":"W Wang","year":"2019","unstructured":"Wang W, Zhu M, Xu Z, Li W, Dong X, Chen Y et al (2019) Ropivacaine promotes apoptosis of hepatocellular carcinoma cells through damaging mitochondria and activating caspase-3 activity. Biol Res 52:36","journal-title":"Biol Res"},{"key":"5144_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2023.110411","volume":"374","author":"X Wei","year":"2023","unstructured":"Wei X, Zeng Y, Meng F, Wang T, Wang H, Yuan Y et al (2023) Calycosin-7-glucoside promotes mitochondria-mediated apoptosis in hepatocellular carcinoma by targeting thioredoxin 1 to regulate oxidative stress. Chem Biol Interact 374:110411","journal-title":"Chem Biol Interact"},{"key":"5144_CR51","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1142\/S0192415X17500835","volume":"45","author":"J Xia","year":"2017","unstructured":"Xia J, Inagaki Y, Gao J, Qi F, Song P, Han G et al (2017) Combination of cinobufacini and doxorubicin increases apoptosis of hepatocellular carcinoma cells through the fas- and mitochondria-mediated pathways. Am J Chin Med 45:1537\u20131556","journal-title":"Am J Chin Med"},{"key":"5144_CR52","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1080\/15548627.2016.1166318","volume":"12","author":"Q Huang","year":"2016","unstructured":"Huang Q, Zhan L, Cao H, Li J, Lyu Y, Guo X et al (2016) Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways. Autophagy 12:999\u20131014","journal-title":"Autophagy"},{"key":"5144_CR53","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1080\/15548627.2016.1151580","volume":"12","author":"M Chen","year":"2016","unstructured":"Chen M, Chen Z, Wang Y, Tan Z, Zhu C, Li Y et al (2016) Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy. Autophagy 12:689\u2013702","journal-title":"Autophagy"},{"key":"5144_CR54","doi-asserted-by":"publisher","first-page":"2775","DOI":"10.1016\/j.bbamcr.2015.02.022","volume":"1853","author":"PA Ney","year":"2015","unstructured":"Ney PA (2015) Mitochondrial autophagy: origins, significance, and role of BNIP3 and NIX. Biochim Biophys Acta 1853:2775\u20132783","journal-title":"Biochim Biophys Acta"},{"key":"5144_CR55","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/nature12748","volume":"504","author":"SA Hasson","year":"2013","unstructured":"Hasson SA, Kane LA, Yamano K, Huang CH, Sliter DA, Buehler E et al (2013) High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. Nature 504:291\u2013295","journal-title":"Nature"},{"key":"5144_CR56","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1002\/jbmr.4019","volume":"35","author":"V Madhu","year":"2020","unstructured":"Madhu V, Boneski PK, Silagi E, Qiu Y, Kurland I, Guntur AR et al (2020) Hypoxic regulation of mitochondrial metabolism and mitophagy in nucleus pulposus cells is dependent on HIF-1\u03b1-BNIP3 axis. J Bone Miner Res 35:1504\u20131524","journal-title":"J Bone Miner Res"},{"key":"5144_CR57","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/s41392-022-01257-8","volume":"7","author":"QJ Wu","year":"2022","unstructured":"Wu QJ, Zhang TN, Chen HH, Yu XF, Lv JL, Liu YY et al (2022) The sirtuin family in health and disease. Signal Transduct Target Ther 7:402","journal-title":"Signal Transduct Target Ther"},{"key":"5144_CR58","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.arr.2017.08.001","volume":"40","author":"M W\u0105troba","year":"2017","unstructured":"W\u0105troba M, Dudek I, Skoda M, Stangret A, Rzodkiewicz P, Szukiewicz D (2017) Sirtuins, epigenetics and longevity. Ageing Res Rev 40:11\u201319","journal-title":"Ageing Res Rev"},{"key":"5144_CR59","doi-asserted-by":"publisher","first-page":"3858","DOI":"10.3390\/ijms21113858","volume":"21","author":"E de Gregorio","year":"2020","unstructured":"de Gregorio E, Colell A, Morales A, Mar\u00ed M (2020) Relevance of SIRT1-NF-\u03baB axis as therapeutic target to ameliorate inflammation in liver disease. Int J Mol Sci 21:3858","journal-title":"Int J Mol Sci"},{"key":"5144_CR60","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.ccr.2011.09.004","volume":"20","author":"HS Kim","year":"2011","unstructured":"Kim HS, Vassilopoulos A, Wang RH, Lahusen T, Xiao Z, Xu X et al (2011) SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC\/C activity. Cancer Cell 20:487\u2013499","journal-title":"Cancer Cell"},{"key":"5144_CR61","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1002\/hep.26278","volume":"57","author":"J Chen","year":"2013","unstructured":"Chen J, Chan AW, To KF, Chen W, Zhang Z, Ren J et al (2013) SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition by protein kinase B\/glycogen synthase kinase-3\u03b2\/\u03b2-catenin signaling. Hepatology 57:2287\u20132298","journal-title":"Hepatology"},{"key":"5144_CR62","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2019.153112","volume":"66","author":"XL Lin","year":"2020","unstructured":"Lin XL, Li K, Yang Z, Chen B, Zhang T (2020) Dulcitol suppresses proliferation and migration of hepatocellular carcinoma via regulating SIRT1\/p53 pathway. Phytomedicine 66:153112","journal-title":"Phytomedicine"},{"key":"5144_CR63","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202256052","volume":"24","author":"J Jin","year":"2023","unstructured":"Jin J, Bai L, Wang D, Ding W, Cao Z, Yan P et al (2023) SIRT3-dependent delactylation of cyclin E2 prevents hepatocellular carcinoma growth. EMBO Rep 24:e56052","journal-title":"EMBO Rep"},{"key":"5144_CR64","doi-asserted-by":"publisher","first-page":"893","DOI":"10.2147\/JHC.S409292","volume":"10","author":"S Liu","year":"2023","unstructured":"Liu S, Kang L, Song Y, Miao M (2023) Role of the HIF-1\u03b1\/BNIP3 signaling pathway in recurrent hepatocellular carcinoma and the mechanism of traditional chinese medicine. J Hepatocell Carcinoma 10:893\u2013908","journal-title":"J Hepatocell Carcinoma"},{"key":"5144_CR65","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.semcancer.2022.12.002","volume":"88","author":"J Zhang","year":"2023","unstructured":"Zhang J, Hu Z, Horta CA, Yang J (2023) Regulation of epithelial-mesenchymal transition by tumor microenvironmental signals and its implication in cancer therapeutics. Semin Cancer Biol 88:46\u201366","journal-title":"Semin Cancer Biol"},{"key":"5144_CR66","doi-asserted-by":"publisher","first-page":"5840","DOI":"10.3390\/ijms21165840","volume":"21","author":"W Olejarz","year":"2020","unstructured":"Olejarz W, Kubiak-Tomaszewska G, Chrzanowska A, Lorenc T (2020) Exosomes in angiogenesis and anti-angiogenic therapy in cancers. Int J Mol Sci 21:5840","journal-title":"Int J Mol Sci"},{"key":"5144_CR67","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1136\/gut.2004.054452","volume":"54","author":"Y Murakami","year":"2005","unstructured":"Murakami Y, Saigo K, Takashima H, Minami M, Okanoue T, Br\u00e9chot C et al (2005) Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas. Gut 54:1162\u20131168","journal-title":"Gut"},{"key":"5144_CR68","doi-asserted-by":"publisher","first-page":"20160274","DOI":"10.1098\/rstb.2016.0274","volume":"372","author":"M Ringelhan","year":"2017","unstructured":"Ringelhan M, McKeating JA, Protzer U (2017) Viral hepatitis and liver cancer. Philos Trans R Soc Lond B Biol Sci 372:20160274","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"5144_CR69","doi-asserted-by":"publisher","DOI":"10.1172\/JCI176345","author":"B Mackowiak","year":"2024","unstructured":"Mackowiak B, Fu Y, Maccioni L, Gao B (2024) Alcohol-associated liver disease. J Clin Invest. https:\/\/doi.org\/10.1172\/JCI176345","journal-title":"J Clin Invest"},{"key":"5144_CR70","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1002\/jcb.30312","volume":"123","author":"E Aryapour","year":"2022","unstructured":"Aryapour E, Kietzmann T (2022) Mitochondria, mitophagy, and the role of deubiquitinases as novel therapeutic targets in liver pathology. J Cell Biochem 123:1634\u20131646","journal-title":"J Cell Biochem"},{"key":"5144_CR71","first-page":"1","volume":"50","author":"J Wang","year":"2018","unstructured":"Wang J, Nisar M, Huang C, Pan X, Lin D, Zheng G et al (2018) Small molecule natural compound agonist of SIRT3 as a therapeutic target for the treatment of intervertebral disc degeneration. Exp Mol Med 50:1\u201314","journal-title":"Exp Mol Med"},{"key":"5144_CR72","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.216621","volume":"587","author":"P Luo","year":"2024","unstructured":"Luo P, An Y, He J, Xing X, Zhang Q, Liu X et al (2024) Icaritin with autophagy\/mitophagy inhibitors synergistically enhances anticancer efficacy and apoptotic effects through PINK1\/Parkin-mediated mitophagy in hepatocellular carcinoma. Cancer Lett 587:216621","journal-title":"Cancer Lett"},{"key":"5144_CR73","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118461","volume":"334","author":"Z Yang","year":"2024","unstructured":"Yang Z, Wang J, Zhao T, Wang L, Liang T, Zheng Y (2024) Mitochondrial structure and function: a new direction for the targeted treatment of chronic liver disease with Chinese herbal medicine. J Ethnopharmacol 334:118461","journal-title":"J Ethnopharmacol"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-024-05144-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-024-05144-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-024-05144-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T06:41:14Z","timestamp":1743748874000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-024-05144-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,27]]},"references-count":73,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["5144"],"URL":"https:\/\/doi.org\/10.1007\/s11010-024-05144-4","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,27]]},"assertion":[{"value":"6 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no financial or proprietary interests in any material discussed in this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"No datasets were generated or analysed during the current study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}}]}}