{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T08:07:26Z","timestamp":1793520446822,"version":"4.5.0"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1007\/s11010-025-05345-5","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T09:47:05Z","timestamp":1752140825000},"page":"5585-5601","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Epigenetic reprogramming by air pollution: linking prenatal exposures to birth outcomes"],"prefix":"10.1007","volume":"480","author":[{"given":"Garvita","family":"Parikh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0594-5452","authenticated-orcid":false,"given":"Bhoomika","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"5345_CR1","unstructured":"World Health Organization (2024) Ambient (outdoor) air pollution. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/ambient-(outdoor)-air-quality-and-health. Accessed 24 May 2025"},{"key":"5345_CR2","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s13148-019-0713-2","volume":"11","author":"CF Rider","year":"2019","unstructured":"Rider CF, Carlsten C (2019) Air pollution and DNA methylation: effects of exposure in humans. Clin Epigenet 11:131. https:\/\/doi.org\/10.1186\/s13148-019-0713-2","journal-title":"Clin Epigenet"},{"key":"5345_CR3","doi-asserted-by":"publisher","first-page":"e34664","DOI":"10.1371\/journal.pone.0034664","volume":"7","author":"I Kloog","year":"2012","unstructured":"Kloog I, Coull BA, Zanobetti A et al (2012) Acute and chronic effects of particles on hospital admissions in New-England. PLoS ONE 7:e34664. https:\/\/doi.org\/10.1371\/journal.pone.0034664","journal-title":"PLoS ONE"},{"key":"5345_CR4","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S40214","author":"S Vieira","year":"2015","unstructured":"Vieira S (2015) The health burden of pollution: the impact of prenatal exposure to air pollutants. COPD. https:\/\/doi.org\/10.2147\/COPD.S40214","journal-title":"COPD"},{"key":"5345_CR5","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1111\/1471-0528.17727","volume":"131","author":"JC Fussell","year":"2024","unstructured":"Fussell JC, Jauniaux E, Smith RB, Burton GJ (2024) Ambient air pollution and adverse birth outcomes: a review of underlying mechanisms. BJOG 131:538\u2013550. https:\/\/doi.org\/10.1111\/1471-0528.17727","journal-title":"BJOG"},{"key":"5345_CR6","doi-asserted-by":"publisher","first-page":"3025","DOI":"10.3390\/cells10113025","volume":"10","author":"T Ghazi","year":"2021","unstructured":"Ghazi T, Naidoo P, Naidoo RN, Chuturgoon AA (2021) Prenatal air pollution exposure and placental DNA methylation changes: implications on fetal development and future disease susceptibility. Cells 10:3025. https:\/\/doi.org\/10.3390\/cells10113025","journal-title":"Cells"},{"key":"5345_CR7","doi-asserted-by":"publisher","first-page":"R27","DOI":"10.1530\/JOE-16-0340","volume":"232","author":"DS Boeldt","year":"2017","unstructured":"Boeldt DS, Bird IM (2017) Vascular adaptation in pregnancy and endothelial dysfunction in preeclampsia. J Endocrinol 232:R27\u2013R44. https:\/\/doi.org\/10.1530\/JOE-16-0340","journal-title":"J Endocrinol"},{"key":"5345_CR8","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz228","author":"MR Miller","year":"2019","unstructured":"Miller MR, Newby DE (2019) Air pollution and cardiovascular disease: car sick. Cardiovasc Res. https:\/\/doi.org\/10.1093\/cvr\/cvz228","journal-title":"Cardiovasc Res"},{"key":"5345_CR9","doi-asserted-by":"publisher","first-page":"109465","DOI":"10.1016\/j.envres.2020.109465","volume":"185","author":"D Prada","year":"2020","unstructured":"Prada D, L\u00f3pez G, Solleiro-Villavicencio H et al (2020) Molecular and cellular mechanisms linking air pollution and bone damage. Environ Res 185:109465. https:\/\/doi.org\/10.1016\/j.envres.2020.109465","journal-title":"Environ Res"},{"key":"5345_CR10","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1007\/s40572-018-0218-8","volume":"5","author":"R Alfano","year":"2018","unstructured":"Alfano R, Herceg Z, Nawrot TS et al (2018) The impact of air pollution on our epigenome: how far is the evidence? (a systematic review). Curr Envir Health Rpt 5:544\u2013578. https:\/\/doi.org\/10.1007\/s40572-018-0218-8","journal-title":"Curr Envir Health Rpt"},{"key":"5345_CR11","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1177\/1947601910393957","volume":"2","author":"B Jin","year":"2011","unstructured":"Jin B, Li Y, Robertson KD (2011) DNA methylation: superior or subordinate in the epigenetic hierarchy? Genes Cancer 2:607\u2013617. https:\/\/doi.org\/10.1177\/1947601910393957","journal-title":"Genes Cancer"},{"key":"5345_CR12","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.114-a160","author":"B Weinhold","year":"2006","unstructured":"Weinhold B (2006) Epigenetics: the science of change. Environ Health Perspect. https:\/\/doi.org\/10.1289\/ehp.114-a160","journal-title":"Environ Health Perspect"},{"key":"5345_CR13","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.envint.2018.05.007","volume":"118","author":"E Abraham","year":"2018","unstructured":"Abraham E, Rousseaux S, Agier L et al (2018) Pregnancy exposure to atmospheric pollution and meteorological conditions and placental DNA methylation. Environ Int 118:334\u2013347. https:\/\/doi.org\/10.1016\/j.envint.2018.05.007","journal-title":"Environ Int"},{"key":"5345_CR14","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.envres.2018.07.008","volume":"167","author":"P Klepac","year":"2018","unstructured":"Klepac P, Locatelli I, Koro\u0161ec S et al (2018) Ambient air pollution and pregnancy outcomes: a comprehensive review and identification of environmental public health challenges. Environ Res 167:144\u2013159. https:\/\/doi.org\/10.1016\/j.envres.2018.07.008","journal-title":"Environ Res"},{"key":"5345_CR15","doi-asserted-by":"publisher","first-page":"109970","DOI":"10.1016\/j.envres.2020.109970","volume":"190","author":"C Li","year":"2020","unstructured":"Li C, Yang M, Zhu Z et al (2020) Maternal exposure to air pollution and the risk of low birth weight: a meta-analysis of cohort studies. Environ Res 190:109970. https:\/\/doi.org\/10.1016\/j.envres.2020.109970","journal-title":"Environ Res"},{"key":"5345_CR16","doi-asserted-by":"publisher","first-page":"116752","DOI":"10.1016\/j.envpol.2021.116752","volume":"278","author":"H Zhang","year":"2021","unstructured":"Zhang H, Zhang X, Wang Q et al (2021) Ambient air pollution and stillbirth: An updated systematic review and meta-analysis of epidemiological studies. Environ Pollut 278:116752. https:\/\/doi.org\/10.1016\/j.envpol.2021.116752","journal-title":"Environ Pollut"},{"key":"5345_CR17","doi-asserted-by":"publisher","first-page":"20140066","DOI":"10.1098\/rstb.2014.0066","volume":"370","author":"GJ Burton","year":"2015","unstructured":"Burton GJ, Fowden AL (2015) The placenta: a multifaceted, transient organ. Phil Trans R Soc B 370:20140066. https:\/\/doi.org\/10.1098\/rstb.2014.0066","journal-title":"Phil Trans R Soc B"},{"key":"5345_CR18","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1101\/gad.947102","volume":"16","author":"A Bird","year":"2002","unstructured":"Bird A (2002) DNA methylation patterns and epigenetic memory. Genes Dev 16:6\u201321. https:\/\/doi.org\/10.1101\/gad.947102","journal-title":"Genes Dev"},{"key":"5345_CR19","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/nrg3142","volume":"13","author":"R Feil","year":"2012","unstructured":"Feil R, Fraga MF (2012) Epigenetics and the environment: emerging patterns and implications. Nat Rev Genet 13:97\u2013109. https:\/\/doi.org\/10.1038\/nrg3142","journal-title":"Nat Rev Genet"},{"key":"5345_CR20","doi-asserted-by":"publisher","first-page":"5624","DOI":"10.1158\/0008-5472.CAN-06-0516","volume":"66","author":"S-M Ho","year":"2006","unstructured":"Ho S-M, Tang W-Y, Belmonte de Frausto J, Prins GS (2006) Developmental exposure to Estradiol and Bisphenol a increases susceptibility to prostate carcinogenesis and epigenetically regulates Phosphodiesterase Type 4 variant 4. Can Res 66:5624\u20135632. https:\/\/doi.org\/10.1158\/0008-5472.CAN-06-0516","journal-title":"Can Res"},{"key":"5345_CR21","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1111\/j.1749-6632.2003.tb05971.x","volume":"983","author":"S Li","year":"2003","unstructured":"Li S, Hursting SD, Davis BJ et al (2003) Environmental exposure, DNA methylation, and gene regulation: lessons from diethylstilbesterol-induced cancers. Ann N Y Acad Sci 983:161\u2013169. https:\/\/doi.org\/10.1111\/j.1749-6632.2003.tb05971.x","journal-title":"Ann N Y Acad Sci"},{"key":"5345_CR22","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s13148-015-0130-0","volume":"7","author":"A Vaiserman","year":"2015","unstructured":"Vaiserman A (2015) Epidemiologic evidence for association between adverse environmental exposures in early life and epigenetic variation: a potential link to disease susceptibility? Clin Epigenet 7:96. https:\/\/doi.org\/10.1186\/s13148-015-0130-0","journal-title":"Clin Epigenet"},{"key":"5345_CR23","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/npp.2012.112","volume":"38","author":"LD Moore","year":"2013","unstructured":"Moore LD, Le T, Fan G (2013) DNA Methylation and Its Basic Function. Neuropsychopharmacol 38:23\u201338. https:\/\/doi.org\/10.1038\/npp.2012.112","journal-title":"Neuropsychopharmacol"},{"key":"5345_CR24","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.1161\/CIRCULATIONAHA.110.956839","volume":"123","author":"DE Handy","year":"2011","unstructured":"Handy DE, Castro R, Loscalzo J (2011) Epigenetic modifications: basic mechanisms and role in cardiovascular disease. Circulation 123:2145\u20132156. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.110.956839","journal-title":"Circulation"},{"key":"5345_CR25","doi-asserted-by":"publisher","first-page":"883","DOI":"10.3892\/mmr.2012.763","volume":"5","author":"O Koukoura","year":"2012","unstructured":"Koukoura O, Sifakis S, Spandidos DA (2012) DNA methylation in the human placenta and fetal growth (Review). Mol Med Rep 5:883\u2013889. https:\/\/doi.org\/10.3892\/mmr.2012.763","journal-title":"Mol Med Rep"},{"key":"5345_CR26","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.mrgentox.2015.12.002","volume":"796","author":"R Ding","year":"2016","unstructured":"Ding R, Jin Y, Liu X et al (2016) Characteristics of DNA methylation changes induced by traffic-related air pollution. Mutat Res\/Genetic Toxicol Env Mutagen 796:46\u201353. https:\/\/doi.org\/10.1016\/j.mrgentox.2015.12.002","journal-title":"Mutat Res\/Genetic Toxicol Env Mutagen"},{"key":"5345_CR27","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.envint.2017.08.006","volume":"108","author":"M Plusquin","year":"2017","unstructured":"Plusquin M, Guida F, Polidoro S et al (2017) DNA methylation and exposure to ambient air pollution in two prospective cohorts. Environ Int 108:127\u2013136. https:\/\/doi.org\/10.1016\/j.envint.2017.08.006","journal-title":"Environ Int"},{"key":"5345_CR28","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/S2213-2600(18)30052-3","volume":"6","author":"C-J Xu","year":"2018","unstructured":"Xu C-J, S\u00f6derh\u00e4ll C, Bustamante M et al (2018) DNA methylation in childhood asthma: an epigenome-wide meta-analysis. Lancet Respir Med 6:379\u2013388. https:\/\/doi.org\/10.1016\/S2213-2600(18)30052-3","journal-title":"Lancet Respir Med"},{"key":"5345_CR29","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1289\/EHP38","volume":"125","author":"ND Saenen","year":"2017","unstructured":"Saenen ND, Vrijens K, Janssen BG et al (2017) Lower placental leptin promoter methylation in association with fine particulate matter air pollution during pregnancy and placental nitrosative stress at birth in the ENVIRONAGE cohort. Environ Health Perspect 125:262\u2013268. https:\/\/doi.org\/10.1289\/EHP38","journal-title":"Environ Health Perspect"},{"key":"5345_CR30","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1743-8977-10-22","volume":"10","author":"BG Janssen","year":"2013","unstructured":"Janssen BG, Godderis L, Pieters N et al (2013) Placental DNA hypomethylation in association with particulate air pollution in early life. Part Fibre Toxicol 10:22. https:\/\/doi.org\/10.1186\/1743-8977-10-22","journal-title":"Part Fibre Toxicol"},{"key":"5345_CR31","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1016\/j.scitotenv.2017.07.029","volume":"607\u2013608","author":"J Cai","year":"2017","unstructured":"Cai J, Zhao Y, Liu P et al (2017) Exposure to particulate air pollution during early pregnancy is associated with placental DNA methylation. Sci Total Environ 607\u2013608:1103\u20131108. https:\/\/doi.org\/10.1016\/j.scitotenv.2017.07.029","journal-title":"Sci Total Environ"},{"key":"5345_CR32","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.envint.2016.03.020","volume":"92\u201393","author":"SL Kingsley","year":"2016","unstructured":"Kingsley SL, Eliot MN, Whitsel EA et al (2016) Maternal residential proximity to major roadways, birth weight, and placental DNA methylation. Environ Int 92\u201393:43\u201349. https:\/\/doi.org\/10.1016\/j.envint.2016.03.020","journal-title":"Environ Int"},{"key":"5345_CR33","doi-asserted-by":"publisher","first-page":"e0199772","DOI":"10.1371\/journal.pone.0199772","volume":"13","author":"Z Maghbooli","year":"2018","unstructured":"Maghbooli Z, Hossein-nezhad A, Adabi E et al (2018) Air pollution during pregnancy and placental adaptation in the levels of global DNA methylation. PLoS ONE 13:e0199772. https:\/\/doi.org\/10.1371\/journal.pone.0199772","journal-title":"PLoS ONE"},{"key":"5345_CR34","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.envint.2019.02.028","volume":"126","author":"C Ladd-Acosta","year":"2019","unstructured":"Ladd-Acosta C, Feinberg JI, Brown SC et al (2019) Epigenetic marks of prenatal air pollution exposure found in multiple tissues relevant for child health. Environ Int 126:363\u2013376. https:\/\/doi.org\/10.1016\/j.envint.2019.02.028","journal-title":"Environ Int"},{"key":"5345_CR35","doi-asserted-by":"publisher","first-page":"106313","DOI":"10.1016\/j.envint.2020.106313","volume":"147","author":"Y Zhao","year":"2021","unstructured":"Zhao Y, Wang P, Zhou Y et al (2021) Prenatal fine particulate matter exposure, placental DNA methylation changes, and fetal growth. Environ Int 147:106313. https:\/\/doi.org\/10.1016\/j.envint.2020.106313","journal-title":"Environ Int"},{"key":"5345_CR36","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1111\/jpc.13356","volume":"52","author":"M Ohn","year":"2016","unstructured":"Ohn M, Jaffe A, Selvadurai H (2016) Persistent growth effects of inhaled corticosteroids. J Paediatr Child Health 52:964\u2013966. https:\/\/doi.org\/10.1111\/jpc.13356","journal-title":"J Paediatr Child Health"},{"key":"5345_CR37","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1080\/15592294.2020.1790923","volume":"16","author":"S Vos","year":"2021","unstructured":"Vos S, Nawrot TS, Martens DS et al (2021) Mitochondrial DNA methylation in placental tissue: a proof of concept study by means of prenatal environmental stressors. Epigenetics 16:121\u2013131. https:\/\/doi.org\/10.1080\/15592294.2020.1790923","journal-title":"Epigenetics"},{"key":"5345_CR38","doi-asserted-by":"publisher","first-page":"13210","DOI":"10.1021\/es404751a","volume":"47","author":"H Li","year":"2013","unstructured":"Li H, Qian X, Wang Q (2013) Heavy metals in atmospheric particulate matter: a comprehensive understanding is needed for monitoring and risk mitigation. Environ Sci Technol 47:13210\u201313211. https:\/\/doi.org\/10.1021\/es404751a","journal-title":"Environ Sci Technol"},{"key":"5345_CR39","doi-asserted-by":"publisher","DOI":"10.29024\/aogh.909","author":"I Alvarado-Cruz","year":"2018","unstructured":"Alvarado-Cruz I, Alegr\u00eda-Torres JA, Montes-Castro N et al (2018) Environmental epigenetic changes, as risk factors for the development of diseases in children: a systematic review. Ann Glob Health. https:\/\/doi.org\/10.29024\/aogh.909","journal-title":"Ann Glob Health"},{"key":"5345_CR40","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1289\/ehp.0800497","volume":"117","author":"JR Pilsner","year":"2009","unstructured":"Pilsner JR, Hu H, Ettinger A et al (2009) Influence of prenatal lead exposure on genomic methylation of cord blood DNA. Environ Health Perspect 117:1466\u20131471. https:\/\/doi.org\/10.1289\/ehp.0800497","journal-title":"Environ Health Perspect"},{"key":"5345_CR41","doi-asserted-by":"publisher","first-page":"494","DOI":"10.4161\/epi.24401","volume":"8","author":"M Kippler","year":"2013","unstructured":"Kippler M, Engstr\u00f6m K, Mlakar SJ et al (2013) Sex-specific effects of early life cadmium exposure on DNA methylation and implications for birth weight. Epigenetics 8:494\u2013503. https:\/\/doi.org\/10.4161\/epi.24401","journal-title":"Epigenetics"},{"key":"5345_CR42","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.envres.2015.02.004","volume":"138","author":"AF Mohanty","year":"2015","unstructured":"Mohanty AF, Farin FM, Bammler TK et al (2015) Infant sex-specific placental cadmium and DNA methylation associations. Environ Res 138:74\u201381. https:\/\/doi.org\/10.1016\/j.envres.2015.02.004","journal-title":"Environ Res"},{"key":"5345_CR43","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.reprotox.2016.08.011","volume":"65","author":"TM Everson","year":"2016","unstructured":"Everson TM, Armstrong DA, Jackson BP et al (2016) Maternal cadmium, placental PCDHAC1, and fetal development. Reprod Toxicol 65:263\u2013271. https:\/\/doi.org\/10.1016\/j.reprotox.2016.08.011","journal-title":"Reprod Toxicol"},{"key":"5345_CR44","doi-asserted-by":"publisher","first-page":"017010","DOI":"10.1289\/EHP2192","volume":"126","author":"TM Everson","year":"2018","unstructured":"Everson TM, Punshon T, Jackson BP et al (2018) Cadmium-associated differential methylation throughout the placental genome: epigenome-wide association study of Two U.S. birth cohorts. Environ Health Perspect 126:017010. https:\/\/doi.org\/10.1289\/EHP2192","journal-title":"Environ Health Perspect"},{"key":"5345_CR45","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1080\/15592294.2015.1046026","volume":"10","author":"A Cardenas","year":"2015","unstructured":"Cardenas A, Koestler DC, Houseman EA et al (2015) Differential DNA methylation in umbilical cord blood of infants exposed to mercury and arsenic in utero. Epigenetics 10:508\u2013515. https:\/\/doi.org\/10.1080\/15592294.2015.1046026","journal-title":"Epigenetics"},{"key":"5345_CR46","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1038\/jes.2013.96","volume":"24","author":"O Drescher","year":"2014","unstructured":"Drescher O, Dewailly E, Diorio C et al (2014) Methylmercury exposure, PON1 gene variants and serum paraoxonase activity in Eastern James Bay Cree adults. J Expo Sci Environ Epidemiol 24:608\u2013614. https:\/\/doi.org\/10.1038\/jes.2013.96","journal-title":"J Expo Sci Environ Epidemiol"},{"key":"5345_CR47","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1038\/s41598-017-00384-5","volume":"7","author":"A Cardenas","year":"2017","unstructured":"Cardenas A, Rifas-Shiman SL, Agha G et al (2017) Persistent DNA methylation changes associated with prenatal mercury exposure and cognitive performance during childhood. Sci Rep 7:288. https:\/\/doi.org\/10.1038\/s41598-017-00384-5","journal-title":"Sci Rep"},{"key":"5345_CR48","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1289\/ehp.1408561","volume":"123","author":"JZJ Maccani","year":"2015","unstructured":"Maccani JZJ, Koestler DC, Lester B et al (2015) Placental DNA methylation related to both infant toenail mercury and adverse neurobehavioral outcomes. Environ Health Perspect 123:723\u2013729. https:\/\/doi.org\/10.1289\/ehp.1408561","journal-title":"Environ Health Perspect"},{"key":"5345_CR49","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.reprotox.2015.05.002","volume":"57","author":"JZJ Maccani","year":"2015","unstructured":"Maccani JZJ, Koestler DC, Houseman EA et al (2015) DNA methylation changes in the placenta are associated with fetal manganese exposure. Reprod Toxicol 57:43\u201349. https:\/\/doi.org\/10.1016\/j.reprotox.2015.05.002","journal-title":"Reprod Toxicol"},{"issue":"reviews0003","key":"5345_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/gb-2001-2-4-reviews0003","volume":"2","author":"PA Grant","year":"2001","unstructured":"Grant PA (2001) A tale of histone modifications. Genome Biol 2(reviews0003):1. https:\/\/doi.org\/10.1186\/gb-2001-2-4-reviews0003","journal-title":"Genome Biol"},{"key":"5345_CR51","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1038\/nm.2053","volume":"15","author":"J Xu","year":"2009","unstructured":"Xu J, Zhang X, Pelayo R et al (2009) Extracellular histones are major mediators of death in sepsis. Nat Med 15:1318\u20131321. https:\/\/doi.org\/10.1038\/nm.2053","journal-title":"Nat Med"},{"key":"5345_CR52","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1161\/CIR.0b013e3181dbece1","volume":"121","author":"RD Brook","year":"2010","unstructured":"Brook RD, Rajagopalan S, Pope CA et al (2010) Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the american heart association. Circulation 121:2331\u20132378. https:\/\/doi.org\/10.1161\/CIR.0b013e3181dbece1","journal-title":"Circulation"},{"key":"5345_CR53","doi-asserted-by":"publisher","first-page":"e205156","DOI":"10.1001\/jamanetworkopen.2020.5156","volume":"3","author":"K Vrijens","year":"2020","unstructured":"Vrijens K, Trippas A-J, Lefebvre W et al (2020) Association of prenatal exposure to ambient air pollution with circulating histone levels in maternal cord blood. JAMA Netw Open 3:e205156. https:\/\/doi.org\/10.1001\/jamanetworkopen.2020.5156","journal-title":"JAMA Netw Open"},{"key":"5345_CR54","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1097\/01.EE9.0000610684.93852.e6","volume":"3","author":"K Vrijens","year":"2019","unstructured":"Vrijens K, Trippas A, Dockx Y et al (2019) Newborn histone modifications and gestational exposure to particulate matter air pollution: the ENVIRONAGE Cohort Study. Env Epidemiol 3:418. https:\/\/doi.org\/10.1097\/01.EE9.0000610684.93852.e6","journal-title":"Env Epidemiol"},{"key":"5345_CR55","doi-asserted-by":"publisher","first-page":"eadp5227","DOI":"10.1126\/sciadv.adp5227","volume":"10","author":"YS Jung","year":"2024","unstructured":"Jung YS, Aguilera J, Kaushik A et al (2024) Impact of air pollution exposure on cytokines and histone modification profiles at single-cell levels during pregnancy. Sci Adv 10:eadp5227. https:\/\/doi.org\/10.1126\/sciadv.adp5227","journal-title":"Sci Adv"},{"key":"5345_CR56","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s43042-024-00553-y","volume":"25","author":"TP George","year":"2024","unstructured":"George TP, Subramanian S, Supriya MH (2024) A brief review of noncoding RNA. Egypt J Med Human Genetics 25:98. https:\/\/doi.org\/10.1186\/s43042-024-00553-y","journal-title":"Egypt J Med Human Genetics"},{"key":"5345_CR57","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1161\/CIRCRESAHA.116.302521","volume":"116","author":"S Uchida","year":"2015","unstructured":"Uchida S, Dimmeler S (2015) Long noncoding RNAs in cardiovascular diseases. Circ Res 116:737\u2013750. https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.302521","journal-title":"Circ Res"},{"key":"5345_CR58","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/nature07242","volume":"455","author":"D Baek","year":"2008","unstructured":"Baek D, Vill\u00e9n J, Shin C et al (2008) The impact of microRNAs on protein output. Nature 455:64\u201371. https:\/\/doi.org\/10.1038\/nature07242","journal-title":"Nature"},{"key":"5345_CR59","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1080\/07853890.2016.1255350","volume":"49","author":"M Montagnana","year":"2017","unstructured":"Montagnana M, Danese E, Lippi G, Fava C (2017) Blood laboratory testing for early prediction of preeclampsia: chasing the finish line or at the starting blocks? Ann Med 49:240\u2013253. https:\/\/doi.org\/10.1080\/07853890.2016.1255350","journal-title":"Ann Med"},{"key":"5345_CR60","doi-asserted-by":"publisher","first-page":"402","DOI":"10.3389\/fendo.2018.00402","volume":"9","author":"J O\u2019Brien","year":"2018","unstructured":"O\u2019Brien J, Hayder H, Zayed Y, Peng C (2018) Overview of microRNA biogenesis, mechanisms of actions, and circulation. Front Endocrinol (Lausanne) 9:402. https:\/\/doi.org\/10.3389\/fendo.2018.00402","journal-title":"Front Endocrinol (Lausanne)"},{"key":"5345_CR61","doi-asserted-by":"publisher","first-page":"S173","DOI":"10.1016\/j.ajog.2015.07.001","volume":"213","author":"MD Mitchell","year":"2015","unstructured":"Mitchell MD, Peiris HN, Kobayashi M et al (2015) Placental exosomes in normal and complicated pregnancy. Am J Obstet Gynecol 213:S173\u2013S181. https:\/\/doi.org\/10.1016\/j.ajog.2015.07.001","journal-title":"Am J Obstet Gynecol"},{"key":"5345_CR62","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","volume":"116","author":"DP Bartel","year":"2004","unstructured":"Bartel DP (2004) MicroRNAs. Cell 116:281\u2013297. https:\/\/doi.org\/10.1016\/S0092-8674(04)00045-5","journal-title":"Cell"},{"key":"5345_CR63","doi-asserted-by":"publisher","first-page":"782.e1","DOI":"10.1016\/j.ajog.2015.01.023","volume":"212","author":"MA Elovitz","year":"2015","unstructured":"Elovitz MA, Anton L, Bastek J, Brown AG (2015) Can microRNA profiling in maternal blood identify women at risk for preterm birth? Am J Obstet Gynecol 212:782.e1-782.e5. https:\/\/doi.org\/10.1016\/j.ajog.2015.01.023","journal-title":"Am J Obstet Gynecol"},{"key":"5345_CR64","doi-asserted-by":"publisher","first-page":"5030","DOI":"10.3390\/ijms24055030","volume":"24","author":"J Ren","year":"2023","unstructured":"Ren J, Jin H, Zhu Y (2023) The role of placental non-coding RNAs in adverse pregnancy outcomes. Int J Mol Sci 24:5030. https:\/\/doi.org\/10.3390\/ijms24055030","journal-title":"Int J Mol Sci"},{"key":"5345_CR65","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.598817","author":"N Gao","year":"2020","unstructured":"Gao N, Li Y, Li J et al (2020) Long non-coding RNAs: the regulatory mechanisms, research strategies, and future directions in cancers. Front Oncol. https:\/\/doi.org\/10.3389\/fonc.2020.598817","journal-title":"Front Oncol"},{"key":"5345_CR66","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1007\/s40572-022-00354-8","volume":"9","author":"S Lapehn","year":"2022","unstructured":"Lapehn S, Paquette AG (2022) The placental epigenome as a molecular link between prenatal exposures and fetal health outcomes through the DOHaD hypothesis. Curr Envir Health Rpt 9:490\u2013501. https:\/\/doi.org\/10.1007\/s40572-022-00354-8","journal-title":"Curr Envir Health Rpt"},{"key":"5345_CR67","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s11845-024-03828-w","volume":"194","author":"C Bao","year":"2025","unstructured":"Bao C, Kuang J, He C, Xu H (2025) The value of lncRNAs as a biomarker for the pregnancy outcomes of gestational diabetes: a meta-analysis. Ir J Med Sci 194:91\u2013100. https:\/\/doi.org\/10.1007\/s11845-024-03828-w","journal-title":"Ir J Med Sci"},{"key":"5345_CR68","doi-asserted-by":"publisher","first-page":"2760","DOI":"10.1111\/jcmm.13570","volume":"22","author":"S Fallen","year":"2018","unstructured":"Fallen S, Baxter D, Wu X et al (2018) Extracellular vesicle RNAs reflect placenta dysfunction and are a biomarker source for preterm labour. J Cell Mol Med 22:2760\u20132773. https:\/\/doi.org\/10.1111\/jcmm.13570","journal-title":"J Cell Mol Med"},{"key":"5345_CR69","doi-asserted-by":"publisher","first-page":"e78487","DOI":"10.1371\/journal.pone.0078487","volume":"8","author":"CL Whitehead","year":"2013","unstructured":"Whitehead CL, Teh WT, Walker SP et al (2013) Circulating microRNAs in maternal blood as potential biomarkers for Fetal Hypoxia In-Utero. PLoS ONE 8:e78487. https:\/\/doi.org\/10.1371\/journal.pone.0078487","journal-title":"PLoS ONE"},{"key":"5345_CR70","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1080\/15592294.2016.1155012","volume":"13","author":"M Tsamou","year":"2018","unstructured":"Tsamou M, Vrijens K, Madhloum N et al (2018) Air pollution-induced placental epigenetic alterations in early life: a candidate miRNA approach. Epigenetics 13:135\u2013146. https:\/\/doi.org\/10.1080\/15592294.2016.1155012","journal-title":"Epigenetics"},{"key":"5345_CR71","doi-asserted-by":"publisher","first-page":"dvaa003","DOI":"10.1093\/eep\/dvaa003","volume":"6","author":"MR Hussey","year":"2020","unstructured":"Hussey MR, Burt A, Deyssenroth MA et al (2020) Placental lncRNA expression associated with placental cadmium concentrations and birth weight. Environ Epigenet 6:dvaa003. https:\/\/doi.org\/10.1093\/eep\/dvaa003","journal-title":"Environ Epigenet"},{"key":"5345_CR72","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1038\/s41390-022-02201-w","volume":"93","author":"JM Tehrani","year":"2023","unstructured":"Tehrani JM, Kennedy E, Tung PW et al (2023) Human placental microRNAs dysregulated by cadmium exposure predict neurobehavioral outcomes at birth. Pediatr Res 93:1410\u20131418. https:\/\/doi.org\/10.1038\/s41390-022-02201-w","journal-title":"Pediatr Res"},{"key":"5345_CR73","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1080\/15592294.2015.1066960","volume":"10","author":"Q Li","year":"2015","unstructured":"Li Q, Kappil MA, Li A et al (2015) Exploring the associations between microRNA expression profiles and environmental pollutants in human placenta from the National Children\u2019s Study (NCS). Epigenetics 10:793\u2013802. https:\/\/doi.org\/10.1080\/15592294.2015.1066960","journal-title":"Epigenetics"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-025-05345-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-025-05345-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-025-05345-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T15:08:27Z","timestamp":1761750507000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-025-05345-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,9]]},"references-count":73,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["5345"],"URL":"https:\/\/doi.org\/10.1007\/s11010-025-05345-5","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,9]]},"assertion":[{"value":"1 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"No ethical approval was required as this is a review article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}