{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:37:35Z","timestamp":1793320655869,"version":"4.5.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100010301","name":"Fakultet Medicinskih Nauka, Univerziteta U Kragujevcu","doi-asserted-by":"publisher","award":["No. 11\/22)"],"award-info":[{"award-number":["No. 11\/22)"]}],"id":[{"id":"10.13039\/501100010301","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"DOI":"10.1007\/s11010-025-05380-2","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T13:12:08Z","timestamp":1757077928000},"page":"213-229","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Exploring the beneficial effects of curcumin-based hydrogel beads in rats with rheumatoid arthritis induced by Freund\u2019s complete adjuvant"],"prefix":"10.1007","volume":"481","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6476-972X","authenticated-orcid":false,"given":"Katarina","family":"Djordjevic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7603-5865","authenticated-orcid":false,"given":"Bozidar","family":"Pindovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1975-1990","authenticated-orcid":false,"given":"Katarina","family":"Mihajlovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Ilic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6860-3015","authenticated-orcid":false,"given":"Jelena","family":"Terzic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2600-1082","authenticated-orcid":false,"given":"Andjela","family":"Milojevic-Samanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4813-9808","authenticated-orcid":false,"given":"Zorka","family":"Stanic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6383-1659","authenticated-orcid":false,"given":"Katarina","family":"Postolovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Ekkert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7853-7356","authenticated-orcid":false,"given":"Vladimir","family":"Reshetnikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9354-9876","authenticated-orcid":false,"given":"Vladimir","family":"Zivkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0071-8376","authenticated-orcid":false,"given":"Vladimir","family":"Jakovljevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9105-1350","authenticated-orcid":false,"given":"Tamara Nikolic","family":"Turnic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,5]]},"reference":[{"issue":"11","key":"5380_CR1","doi-asserted-by":"publisher","first-page":"2857","DOI":"10.3390\/cells10112857","volume":"10","author":"AF Radu","year":"2021","unstructured":"Radu AF, Bungau SG (2021) Management of rheumatoid arthritis: an overview. Cells 10(11):2857. https:\/\/doi.org\/10.3390\/cells10112857","journal-title":"Cells"},{"issue":"10416","key":"5380_CR2","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1016\/S0140-6736(23)01525-8","volume":"402","author":"A Di Matteo","year":"2023","unstructured":"Di Matteo A, Bathon JM, Emery P (2023) Rheumatoid arthritis. Lancet 402(10416):2019\u20132033. https:\/\/doi.org\/10.1016\/S0140-6736(23)01525-8","journal-title":"Lancet"},{"issue":"2","key":"5380_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102735","volume":"20","author":"A Conforti","year":"2021","unstructured":"Conforti A, Di Cola I, Pavlych V et al (2021) Beyond the joints, the extra-articular manifestations in rheumatoid arthritis. Autoimmun Rev 20(2):102735. https:\/\/doi.org\/10.1016\/j.autrev.2020.102735","journal-title":"Autoimmun Rev"},{"key":"5380_CR4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2022-070856","volume":"384","author":"P Brown","year":"2024","unstructured":"Brown P, Pratt AG, Hyrich KL (2024) Therapeutic advances in rheumatoid arthritis. BMJ 384:e070856. https:\/\/doi.org\/10.1136\/bmj-2022-070856","journal-title":"BMJ"},{"issue":"6","key":"5380_CR5","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1159\/000493390","volume":"27","author":"J Bullock","year":"2018","unstructured":"Bullock J, Rizvi SAA, Saleh AM et al (2018) Rheumatoid arthritis: a brief overview of the treatment. Med Princ Pract 27(6):501\u2013507. https:\/\/doi.org\/10.1159\/000493390","journal-title":"Med Princ Pract"},{"key":"5380_CR6","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1093\/rheumatology\/keq135","volume":"49","author":"CM Bartels","year":"2010","unstructured":"Bartels CM, Bell CL, Shinki K, Rosenthal A, Bridges AJ (2010) Changing trends in serious extra-articular manifestations of rheumatoid arthritis among United State veterans over 20 years. Rheumatology (Oxford) 49:1670\u20131675. https:\/\/doi.org\/10.1093\/rheumatology\/keq135","journal-title":"Rheumatology (Oxford)"},{"key":"5380_CR7","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.jbspin.2012.02.005","volume":"80","author":"S Dadoun","year":"2013","unstructured":"Dadoun S, Zeboulon-Ktorza N, Combescure C et al (2013) Mortality in rheumatoid arthritis over the last fifty years: systematic review and meta-analysis. Joint Bone Spine 80:29\u201333. https:\/\/doi.org\/10.1016\/j.jbspin.2012.02.005","journal-title":"Joint Bone Spine"},{"issue":"10055","key":"5380_CR8","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","volume":"388","author":"JS Smolen","year":"2016","unstructured":"Smolen JS, Aletaha D, McInnes IB (2016) Rheumatoid arthritis. Lancet 388(10055):2023\u20132038. https:\/\/doi.org\/10.1016\/S0140-6736(16)30173-8","journal-title":"Lancet"},{"issue":"5","key":"5380_CR9","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/0010-7824(87)90082-5","volume":"35","author":"MP Vessey","year":"1987","unstructured":"Vessey MP, Villard-Mackintosh L, Yeates D (1987) Oral contraceptives, cigarette smoking and other factors in relation to arthritis. Contraception 35(5):457\u2013464. https:\/\/doi.org\/10.1016\/0010-7824(87)90082-5","journal-title":"Contraception"},{"issue":"7","key":"5380_CR10","first-page":"1310","volume":"31","author":"DJ Pattison","year":"2004","unstructured":"Pattison DJ, Harrison RA, Symmons DPM (2004) The role of diet in susceptibility to rheumatoid arthritis: a systematic review. J Rheumatol 31(7):1310\u20131319","journal-title":"J Rheumatol"},{"issue":"4","key":"5380_CR11","doi-asserted-by":"publisher","first-page":"880","DOI":"10.3390\/cells9040880","volume":"9","author":"YJ Lin","year":"2020","unstructured":"Lin YJ, Anzaghe M, Sch\u00fclke S (2020) Update on the pathomechanism, diagnosis, and treatment options for rheumatoid arthritis. Cells 9(4):880. https:\/\/doi.org\/10.3390\/cells9040880","journal-title":"Cells"},{"key":"5380_CR12","doi-asserted-by":"publisher","unstructured":"Strand V, Kavanaugh AF (2004) The role of interleukin-1 in bone resorption in rheumatoid arthritis. Rheumatology (Oxford) 43(3):iii10-iii16. https:\/\/doi.org\/10.1093\/rheumatology\/keh200","DOI":"10.1093\/rheumatology\/keh200"},{"key":"5380_CR13","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7536805","volume":"2019","author":"LJS da Fonseca","year":"2019","unstructured":"da Fonseca LJS, Nunes-Souza V, Goulart MOF, Rabelo LA (2019) Oxidative stress in rheumatoid arthritis: what the future might hold regarding novel biomarkers and add-on therapies. Oxid Med Cell Longev 2019:7536805. https:\/\/doi.org\/10.1155\/2019\/7536805","journal-title":"Oxid Med Cell Longev"},{"issue":"6","key":"5380_CR14","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.3390\/antiox11061151","volume":"11","author":"MJ L\u00f3pez-Armada","year":"2022","unstructured":"L\u00f3pez-Armada MJ, Fern\u00e1ndez-Rodr\u00edguez JA, Blanco FJ (2022) Mitochondrial dysfunction and oxidative stress in rheumatoid arthritis. Antioxidants (Basel) 11(6):1151. https:\/\/doi.org\/10.3390\/antiox11061151","journal-title":"Antioxidants (Basel)"},{"issue":"7","key":"5380_CR15","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1080\/10715762.2019.1629586","volume":"53","author":"A Pradhan","year":"2019","unstructured":"Pradhan A, Bagchi A, De S et al (2019) Role of redox imbalance and cytokines in mediating oxidative damage and disease progression of patients with rheumatoid arthritis. Free Radic Res 53(7):768\u2013779. https:\/\/doi.org\/10.1080\/10715762.2019.1629586","journal-title":"Free Radic Res"},{"issue":"1","key":"5380_CR16","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/s13075-018-1592-1","volume":"20","author":"E Balogh","year":"2018","unstructured":"Balogh E, Veale DJ, McGarry T et al (2018) Oxidative stress impairs energy metabolism in primary cells and synovial tissue of patients with rheumatoid arthritis. Arthritis Res Ther 20(1):95. https:\/\/doi.org\/10.1186\/s13075-018-1592-1","journal-title":"Arthritis Res Ther"},{"issue":"9","key":"5380_CR17","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1007\/s00296-017-3771-9","volume":"37","author":"H Hirvonen","year":"2017","unstructured":"Hirvonen H, Kautiainen H, Moilanen E, Mikkelsson M, Leirisalo-Repo M (2017) The effect of cryotherapy on total antioxidative capacity in patients with active seropositive rheumatoid arthritis. Rheumatol Int 37(9):1481\u20131487. https:\/\/doi.org\/10.1007\/s00296-017-3771-9","journal-title":"Rheumatol Int"},{"issue":"1","key":"5380_CR18","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/ejcn.2016.151","volume":"71","author":"M Ghavipour","year":"2017","unstructured":"Ghavipour M, Sotoudeh G, Tavakoli E, Mowla K, Hasanzadeh J, Mazloom Z (2017) Pomegranate extract alleviates disease activity and some blood biomarkers of inflammation and oxidative stress in rheumatoid arthritis patients. Eur J Clin Nutr 71(1):92\u201396. https:\/\/doi.org\/10.1038\/ejcn.2016.151","journal-title":"Eur J Clin Nutr"},{"key":"5380_CR19","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.freeradbiomed.2018.05.086","volume":"125","author":"MJ Smallwood","year":"2018","unstructured":"Smallwood MJ, Nissim A, Knight AR, Whiteman M, Haigh R, Winyard PG (2018) Oxidative stress in autoimmune rheumatic diseases. Free Radic Biol Med 125:3\u201314. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2018.05.086","journal-title":"Free Radic Biol Med"},{"key":"5380_CR20","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.cbi.2017.12.024","volume":"281","author":"AR Phull","year":"2018","unstructured":"Phull AR, Nasir B, Haq IU, Kim SJ (2018) Oxidative stress, consequences and ROS mediated cellular signaling in rheumatoid arthritis. Chem Biol Interact 281:121\u2013136. https:\/\/doi.org\/10.1016\/j.cbi.2017.12.024","journal-title":"Chem Biol Interact"},{"issue":"1","key":"5380_CR21","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1186\/s13075-015-0736-9","volume":"17","author":"D Aletaha","year":"2015","unstructured":"Aletaha D, Alasti F, Smolen JS (2015) Rheumatoid factor, not antibodies against citrullinated proteins, is associated with baseline disease activity in rheumatoid arthritis clinical trials. Arthritis Res Ther 17(1):229. https:\/\/doi.org\/10.1186\/s13075-015-0736-9","journal-title":"Arthritis Res Ther"},{"key":"5380_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.1","volume":"4","author":"JS Smolen","year":"2018","unstructured":"Smolen JS, Aletaha D, Barton A et al (2018) Rheumatoid arthritis. Nat Rev Dis Primers 4:18001. https:\/\/doi.org\/10.1038\/nrdp.2018.1","journal-title":"Nat Rev Dis Primers"},{"issue":"1","key":"5380_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/art.39480","volume":"68","author":"JA Singh","year":"2016","unstructured":"Singh JA, Saag KG, Bridges SL et al (2016) 2015 American college of rheumatology guideline for the treatment of rheumatoid arthritis. Arthritis Rheumatol 68(1):1\u201326. https:\/\/doi.org\/10.1002\/art.39480","journal-title":"Arthritis Rheumatol"},{"issue":"41","key":"5380_CR24","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012658","volume":"97","author":"MDG Moura","year":"2018","unstructured":"Moura MDG, Lopes LC, Silva MT, Barberato-Filho S, Motta RHL, Bergamaschi CC (2018) Use of steroid and nonsteroidal anti-inflammatories in the treatment of rheumatoid arthritis: systematic review protocol. Medicine (Baltimore) 97(41):e12658. https:\/\/doi.org\/10.1097\/MD.0000000000012658","journal-title":"Medicine (Baltimore)"},{"issue":"4","key":"5380_CR25","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1007\/s10067-016-3528-y","volume":"36","author":"S Monti","year":"2017","unstructured":"Monti S, Klersy C, Gorla R et al (2017) Factors influencing the choice of first- and second-line biologic therapy for the treatment of rheumatoid arthritis: real-life data from the Italian LORHEN registry. Clin Rheumatol 36(4):753\u2013761. https:\/\/doi.org\/10.1007\/s10067-016-3528-y","journal-title":"Clin Rheumatol"},{"issue":"7","key":"5380_CR26","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8070938","volume":"8","author":"BM K\u00f6hler","year":"2019","unstructured":"K\u00f6hler BM, G\u00fcnther J, Kaudewitz D, Lorenz HM (2019) Current therapeutic options in the treatment of rheumatoid arthritis. J Clin Med 8(7):938. https:\/\/doi.org\/10.3390\/jcm8070938","journal-title":"J Clin Med"},{"issue":"3","key":"5380_CR27","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1007\/s10787-024-01445-8","volume":"32","author":"C Kaur","year":"2024","unstructured":"Kaur C, Mishra Y, Kumar R et al (2024) Pathophysiology, diagnosis, and herbal medicine-based therapeutic implication of rheumatoid arthritis: an overview. Inflammopharmacology 32(3):1705\u20131720. https:\/\/doi.org\/10.1007\/s10787-024-01445-8","journal-title":"Inflammopharmacology"},{"issue":"11","key":"5380_CR28","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12111938","volume":"12","author":"K Djordjevic","year":"2023","unstructured":"Djordjevic K, Milojevic Samanovic A, Veselinovic M et al (2023) Oxidative stress mediated therapy in patients with rheumatoid arthritis: a systematic review and meta-analysis. Antioxidants 12(11):1938. https:\/\/doi.org\/10.3390\/antiox12111938","journal-title":"Antioxidants"},{"key":"5380_CR29","doi-asserted-by":"publisher","first-page":"1024120","DOI":"10.3389\/fimmu.2023.1024120","volume":"14","author":"Z Long","year":"2023","unstructured":"Long Z, Xiang W, He Q et al (2023) Efficacy and safety of dietary polyphenols in rheumatoid arthritis: a systematic review and meta-analysis of 47 randomized controlled trials. Front Immunol 14:1024120. https:\/\/doi.org\/10.3389\/fimmu.2023.1024120","journal-title":"Front Immunol"},{"key":"5380_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/112_2020_54","volume":"179","author":"S MohammadianHaftcheshmeh","year":"2021","unstructured":"MohammadianHaftcheshmeh S, Khosrojerdi A, Aliabadi A, Lotfi S, Mohammadi A, Momtazi-Borojeni AA (2021) Immunomodulatory effects of curcumin in rheumatoid arthritis: evidence from molecular mechanisms to clinical outcomes. Rev Physiol Biochem Pharmacol 179:1\u201329. https:\/\/doi.org\/10.1007\/112_2020_54","journal-title":"Rev Physiol Biochem Pharmacol"},{"issue":"16","key":"5380_CR31","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24162930","volume":"24","author":"RR Kotha","year":"2019","unstructured":"Kotha RR, Luthria DL (2019) Curcumin: biological, pharmaceutical, nutraceutical, and analytical aspects. Molecules 24(16):2930. https:\/\/doi.org\/10.3390\/molecules24162930","journal-title":"Molecules"},{"issue":"3","key":"5380_CR32","doi-asserted-by":"publisher","first-page":"264","DOI":"10.3390\/molecules21030264","volume":"21","author":"M Pulido-Moran","year":"2016","unstructured":"Pulido-Moran M, Moreno-Fernandez J, Ramirez-Tortosa C, Ramirez-Tortosa M (2016) Curcumin and health. Molecules 21(3):264. https:\/\/doi.org\/10.3390\/molecules21030264","journal-title":"Molecules"},{"issue":"39","key":"5380_CR33","doi-asserted-by":"publisher","first-page":"66680","DOI":"10.18632\/oncotarget.19164","volume":"8","author":"M Gera","year":"2017","unstructured":"Gera M, Sharma N, Ghosh M et al (2017) Nanoformulations of curcumin: an emerging paradigm for improved remedial application. Oncotarget 8(39):66680\u201366698. https:\/\/doi.org\/10.18632\/oncotarget.19164","journal-title":"Oncotarget"},{"issue":"13","key":"5380_CR34","doi-asserted-by":"publisher","first-page":"4045","DOI":"10.3390\/molecules27134045","volume":"27","author":"KS Postolovi\u0107","year":"2022","unstructured":"Postolovi\u0107 KS, Antonijevi\u0107 MD, Ljuji\u0107 B, Mileti\u0107 Kova\u010devi\u0107 M, Gazdi\u0107 Jankovi\u0107 M, Stani\u0107 ZD (2022) pH-responsive hydrogel beads based on alginate, \u03ba-carrageenan and poloxamer for enhanced curcumin, natural bioactive compound, encapsulation and controlled release efficiency. Molecules 27(13):4045. https:\/\/doi.org\/10.3390\/molecules27134045","journal-title":"Molecules"},{"key":"5380_CR35","doi-asserted-by":"publisher","first-page":"4095","DOI":"10.2147\/DDDT.S175763","volume":"12","author":"Q Dai","year":"2018","unstructured":"Dai Q, Zhou D, Xu L, Song X (2018) Curcumin alleviates rheumatoid arthritis-induced inflammation and synovial hyperplasia by targeting mTOR pathway in rats. Drug Des Devel Ther 12:4095\u20134105. https:\/\/doi.org\/10.2147\/DDDT.S175763","journal-title":"Drug Des Devel Ther"},{"issue":"1","key":"5380_CR36","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s10020-022-00432-5","volume":"28","author":"KS El-Said","year":"2022","unstructured":"El-Said KS, Atta A, Mobasher MA, Germoush MO, Mohamed TM, Salem MM (2022) Quercetin mitigates rheumatoid arthritis by inhibiting adenosine deaminase in rats. Mol Med 28(1):24. https:\/\/doi.org\/10.1186\/s10020-022-00432-5","journal-title":"Mol Med"},{"key":"5380_CR37","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.887460","volume":"13","author":"T Zhao","year":"2022","unstructured":"Zhao T, Xie Z, Xi Y, Liu L, Li Z, Qin D (2022) How to model rheumatoid arthritis in animals: from rodents to non-human primates. Front Immunol 13:887460. https:\/\/doi.org\/10.3389\/fimmu.2022.887460","journal-title":"Front Immunol"},{"key":"5380_CR38","first-page":"123","volume-title":"Handbook of methods for oxygen radical research","author":"C Auclair","year":"1985","unstructured":"Auclair C, Voisin E (1985) Nitroblue tetrazolium reduction. In: Greenvvald RA (ed) Handbook of methods for oxygen radical research, 1st edn. CRC Press Une, Boca Raton, pp 123\u2013132","edition":"1"},{"issue":"1\u20132","key":"5380_CR39","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/0022-1759(80)90340-3","volume":"38","author":"E Pick","year":"1980","unstructured":"Pick E, Keisari Y (1980) A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture. J Immunol Methods 38(1\u20132):161\u2013170. https:\/\/doi.org\/10.1016\/0022-1759(80)90340-3","journal-title":"J Immunol Methods"},{"issue":"1","key":"5380_CR40","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-x","volume":"126","author":"LC Green","year":"1982","unstructured":"Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR (1982) Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids. Anal Biochem 126(1):131\u2013138. https:\/\/doi.org\/10.1016\/0003-2697(82)90118-x","journal-title":"Anal Biochem"},{"issue":"5","key":"5380_CR41","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1080\/13813455.2018.1551904","volume":"126","author":"J Bradic","year":"2020","unstructured":"Bradic J, Jeremic N, Petkovic A et al (2020) Cardioprotective effects of Galium verum L. extract against myocardial ischemiareperfusion injury. Arch Physiol Biochem 126(5):408\u2013415. https:\/\/doi.org\/10.1080\/13813455.2018.1551904","journal-title":"Arch Physiol Biochem"},{"key":"5380_CR42","first-page":"83","volume-title":"Red cell metabolism: a manual of biochemical methods","author":"E Beutler","year":"1984","unstructured":"Beutler E (1984) Superoxide dismutase. In: Beutler E (ed) Red cell metabolism: a manual of biochemical methods, 3rd edn. Grune & Stratton, New York, pp 83\u201385","edition":"3"},{"key":"5380_CR43","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/s0076-6879(84)05016-3","volume":"105","author":"H Aebi","year":"1984","unstructured":"Aebi H (1984) Catalase in vitro. Methods Enzymol 105:121\u2013126. https:\/\/doi.org\/10.1016\/s0076-6879(84)05016-3","journal-title":"Methods Enzymol"},{"key":"5380_CR44","first-page":"112","volume-title":"Red cell metabolism: a manual of biochemical methods","author":"E Beutler","year":"1975","unstructured":"Beutler E (1975) Reduced glutathione (GSH). In: Beutler E (ed) Red cell metabolism: a manual of biochemical methods, 2nd edn. Grune & Stratton, New York, pp 112\u2013114","edition":"2"},{"issue":"4","key":"5380_CR45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152925","volume":"11","author":"S Mateen","year":"2016","unstructured":"Mateen S, Moin S, Khan AQ, Zafar A, Fatima N (2016) Increased reactive oxygen species formation and oxidative stress in rheumatoid arthritis. PLoS One 11(4):e0152925. https:\/\/doi.org\/10.1371\/journal.pone.0152925","journal-title":"PLoS One"},{"issue":"14","key":"5380_CR46","doi-asserted-by":"publisher","first-page":"5747","DOI":"10.1002\/jsfa.11372","volume":"101","author":"MEA El-Hack","year":"2021","unstructured":"El-Hack MEA, El-Saadony MT, Swelum AA, Arif M, Ghanima MMA, Shukry M, Noreldin A, Taha AE, El-Tarabily KA (2021) Curcumin, the active substance of turmeric: its effects on health and ways to improve its bioavailability. J Sci Food Agric 101(14):5747\u20135762. https:\/\/doi.org\/10.1002\/jsfa.11372","journal-title":"J Sci Food Agric"},{"issue":"10","key":"5380_CR47","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.3390\/pharmaceutics13101715","volume":"13","author":"R Tabanelli","year":"2021","unstructured":"Tabanelli R, Brogi S, Calderone V (2021) Improving curcumin bioavailability: current strategies and future perspectives. Pharmaceutics 13(10):1715. https:\/\/doi.org\/10.3390\/pharmaceutics13101715","journal-title":"Pharmaceutics"},{"issue":"1\u20132","key":"5380_CR48","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s11010-014-2006-6","volume":"391","author":"M Veselinovic","year":"2014","unstructured":"Veselinovic M, Barudzic N, Vuletic M, Zivkovic V, Tomic-Lucic A, Djuric D, Jakovljevic V (2014) Oxidative stress in rheumatoid arthritis patients: relationship to diseases activity. Mol Cell Biochem 391(1\u20132):225\u201332. https:\/\/doi.org\/10.1007\/s11010-014-2006-6","journal-title":"Mol Cell Biochem"},{"issue":"5","key":"5380_CR49","doi-asserted-by":"publisher","first-page":"546","DOI":"10.4103\/0253-7613.84970","volume":"43","author":"D Banji","year":"2011","unstructured":"Banji D, Pinnapureddy J, Banji OJF, Kumar AR, Reddy KN (2011) Evaluation of the concomitant use of methotrexate and curcumin on Freund\u2019s complete adjuvant-induced arthritis and hematological indices in rats. Indian J Pharmacol 43(5):546\u201350. https:\/\/doi.org\/10.4103\/0253-7613.84970","journal-title":"Indian J Pharmacol"},{"issue":"8","key":"5380_CR50","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10081239","volume":"10","author":"C Longobardi","year":"2021","unstructured":"Longobardi C, Damiano S, Andretta E, Prisco F, Russo V, Pagnini F, Florio S, Ciarcia R (2021) Curcumin modulates nitrosative stress, inflammation, and DNA damage and protects against ochratoxin A-induced hepatotoxicity and nephrotoxicity in rats. Antioxidants 10(8):1239. https:\/\/doi.org\/10.3390\/antiox10081239","journal-title":"Antioxidants"},{"issue":"7","key":"5380_CR51","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26072873","volume":"26","author":"R Bilski","year":"2025","unstructured":"Bilski R, Nuszkiewicz J (2025) Antioxidant therapies as emerging adjuncts in rheumatoid arthritis: targeting oxidative stress to enhance treatment outcomes. Int J Mol Sci 26(7):2873. https:\/\/doi.org\/10.3390\/ijms26072873","journal-title":"Int J Mol Sci"},{"issue":"2","key":"5380_CR52","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3109\/19390211.2015.1008611","volume":"13","author":"Y Panahi","year":"2016","unstructured":"Panahi Y, Alishiri GH, Parvin S, Sahebkar A (2016) Mitigation of systemic oxidative stress by curcuminoids in osteoarthritis: results of a randomized controlled trial. J Diet Suppl 13(2):209\u2013220. https:\/\/doi.org\/10.3109\/19390211.2015.1008611","journal-title":"J Diet Suppl"},{"issue":"4","key":"5380_CR53","doi-asserted-by":"publisher","DOI":"10.3390\/ph16040481","volume":"16","author":"AI Matouk","year":"2023","unstructured":"Matouk AI, Awad EM, El-Tahawy NFG, El-Sheikh AAK, Anter A (2023) Dihydromyricetin modulates Nrf2 and NF-\u03baB crosstalk to alleviate methotrexate-induced lung toxicity. Pharmaceuticals (Basel) 16(4):481. https:\/\/doi.org\/10.3390\/ph16040481","journal-title":"Pharmaceuticals (Basel)"},{"issue":"1\u20132","key":"5380_CR54","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.ejphar.2011.06.006","volume":"668","author":"D Banji","year":"2011","unstructured":"Banji D, Pinnapureddy J, Banji OJF, Saidulu A, Hayath MS (2011) Eur J Pharmacol 668(1\u20132):293\u20138. https:\/\/doi.org\/10.1016\/j.ejphar.2011.06.006","journal-title":"Eur J Pharmacol"},{"issue":"6","key":"5380_CR55","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1007\/s10928-013-9341-1","volume":"40","author":"HK Lon","year":"2013","unstructured":"Lon HK, Liu D, DuBois DC, Almon RR, Jusko WJ (2013) Modeling pharmacokinetics\/pharmacodynamics of abatacept and disease progression in collagen-induced arthritic rats - a population approach. J Pharmacokinet Pharmacodyn 40(6):701\u2013712. https:\/\/doi.org\/10.1007\/s10928-013-9341-1","journal-title":"J Pharmacokinet Pharmacodyn"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-025-05380-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-025-05380-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-025-05380-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T09:25:57Z","timestamp":1771061157000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-025-05380-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,5]]},"references-count":55,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["5380"],"URL":"https:\/\/doi.org\/10.1007\/s11010-025-05380-2","relation":{},"ISSN":["1573-4919"],"issn-type":[{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,5]]},"assertion":[{"value":"24 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Ethical Committee of the Faculty of Medical Sciences, University of Kragujevac for the use of animals in experiments (No. 01-10540\/1). Experiments are conducted in accordance with the guidelines of Good Laboratory Practice.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}