{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:37:03Z","timestamp":1793147823038,"version":"4.5.0"},"reference-count":210,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Social Development Special Fund of Yunnan Province Science and Technology Department","award":["202403AC100017"],"award-info":[{"award-number":["202403AC100017"]}]},{"name":"Project of Xi'an Municipal Health Commission","award":["2024ms03"],"award-info":[{"award-number":["2024ms03"]}]},{"name":"Innovation Capability Support Plan-Medical Research Project of Xi\u2019an Science and Technology Bureau","award":["23YXYJ0001"],"award-info":[{"award-number":["23YXYJ0001"]}]},{"name":"Key Research and Development Project of the Tibet Autonomous Region","award":["XZ202501ZY0044"],"award-info":[{"award-number":["XZ202501ZY0044"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82570479"],"award-info":[{"award-number":["82570479"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"crossref","award":["2025JC-YBMS-880"],"award-info":[{"award-number":["2025JC-YBMS-880"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"DOI":"10.1007\/s11010-025-05401-0","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:33:38Z","timestamp":1760099618000},"page":"81-107","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Yin and Yang of copper in cardiovascular health and disease"],"prefix":"10.1007","volume":"481","author":[{"given":"Jiaoyu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianran","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyan","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"key":"5401_CR1","unstructured":"World Heart Report 2023: Full Report. Available from: https:\/\/world-heart-federation.org\/world-heart-report-2023\/."},{"key":"5401_CR2","first-page":"e78268","volume":"17","author":"HK Krishnamurthy","year":"2025","unstructured":"Krishnamurthy HK, Reddy S, Jayaraman V, Krishna K, Song Q, Wang T, Bei K, Rajasekaran JJ (2025) Profiling the Effect of Micronutrient Levels on Vital Cardiovascular Markers. Cureus 17:e78268","journal-title":"Cureus"},{"key":"5401_CR3","doi-asserted-by":"publisher","first-page":"110173","DOI":"10.1016\/j.cbi.2022.110173","volume":"367","author":"K Jomova","year":"2022","unstructured":"Jomova K, Makova M, Alomar SY, Alwasel SH, Nepovimova E, Kuca K, Rhodes CJ, Valko M (2022) Essential metals in health and disease. Chem Biol Interact 367:110173","journal-title":"Chem Biol Interact"},{"key":"5401_CR4","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1093\/ajcn\/63.5.797","volume":"63","author":"MC Linder","year":"1996","unstructured":"Linder MC, Hazegh-Azam M (1996) Copper biochemistry and molecular biology. Am J Clin Nutr 63:797\u2013811","journal-title":"Am J Clin Nutr"},{"key":"5401_CR5","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1002\/biof.5520100406","volume":"10","author":"JT Saari","year":"1999","unstructured":"Saari JT, Schuschke DA (1999) Cardiovascular effects of dietary copper deficiency. BioFactors 10:359\u2013375","journal-title":"BioFactors"},{"key":"5401_CR6","doi-asserted-by":"publisher","first-page":"122711","DOI":"10.1016\/j.envpol.2023.122711","volume":"340","author":"H Zhao","year":"2024","unstructured":"Zhao H, Mei K, Hu Q, Wu Y, Xu Y, Qinling P, Yu Y, Deng W, Zhu ZY, Liu X (2024) Circulating copper levels and the risk of cardio-cerebrovascular diseases and cardiovascular and all-cause mortality: a systematic review and meta-analysis of longitudinal studies. Environ Pollut 340:122711","journal-title":"Environ Pollut"},{"key":"5401_CR7","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s11325-022-02595-1","volume":"27","author":"N Dong","year":"2023","unstructured":"Dong N, Liu WY (2023) Regulatory mechanism of downregulation of SOD1 expression on cardiomyocyte function. Sleep Breath 27:399\u2013410","journal-title":"Sleep Breath"},{"key":"5401_CR8","doi-asserted-by":"publisher","first-page":"711227","DOI":"10.3389\/fmolb.2021.711227","volume":"8","author":"LM Ruiz","year":"2021","unstructured":"Ruiz LM, Libedinsky A, Elorza AA (2021) Role of Copper on Mitochondrial Function and Metabolism. Front Mol Biosci 8:711227","journal-title":"Front Mol Biosci"},{"key":"5401_CR9","doi-asserted-by":"publisher","first-page":"5418376","DOI":"10.1155\/2022\/5418376","volume":"2022","author":"X Cui","year":"2022","unstructured":"Cui X, Wang Y, Liu H, Shi M, Wang J, Wang Y (2022) The molecular mechanisms of defective copper metabolism in diabetic cardiomyopathy. Oxid Med Cell Longev 2022:5418376","journal-title":"Oxid Med Cell Longev"},{"key":"5401_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.scib.2025.05.019","author":"L Chen","year":"2025","unstructured":"Chen L, Wu Q, Lin C, Song Z, Su Y, Ge C, Wang X, Luo H, Wang R, Wang Y, Min J, Wang F (2025) Integrative analysis of copper dysregulation and cuproptosis in postnatal hematopoiesis. Sci Bull. https:\/\/doi.org\/10.1016\/j.scib.2025.05.019","journal-title":"Sci Bull"},{"key":"5401_CR11","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1161\/CIRCULATIONAHA.104.512988","volume":"112","author":"IS Anand","year":"2005","unstructured":"Anand IS, Kuskowski MA, Rector TS, Florea VG, Glazer RD, Hester A, Chiang YT, Aknay N, Maggioni AP, Opasich C, Latini R, Cohn JN (2005) Anemia and change in hemoglobin over time related to mortality and morbidity in patients with chronic heart failure: results from Val-HeFT. Circulation 112:1121\u20131127","journal-title":"Circulation"},{"key":"5401_CR12","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/jth.14360","volume":"17","author":"JW Weisel","year":"2019","unstructured":"Weisel JW, Litvinov RI (2019) Red blood cells: the forgotten player in hemostasis and thrombosis. J Thromb Haemost 17:271\u2013282","journal-title":"J Thromb Haemost"},{"key":"5401_CR13","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/s41556-021-00822-7","volume":"24","author":"A Das","year":"2022","unstructured":"Das A, Ash D, Fouda AY, Sudhahar V, Kim YM, Hou Y, Hudson FZ, Stansfield BK, Caldwell RB, McMenamin M, Littlejohn R, Su H, Regan MR, Merrill BJ, Poole LB, Kaplan JH, Fukai T, Ushio-Fukai M (2022) Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis. Nat Cell Biol 24:35\u201350","journal-title":"Nat Cell Biol"},{"key":"5401_CR14","doi-asserted-by":"publisher","first-page":"2647","DOI":"10.1097\/CM9.0000000000001772","volume":"134","author":"P Li","year":"2021","unstructured":"Li P, Dong XR, Zhang B, Zhang XT, Liu JZ, Ma DS, Ma L (2021) Molecular mechanism and therapeutic targeting of necrosis, apoptosis, pyroptosis, and autophagy in cardiovascular disease. Chin Med J (Engl) 134:2647\u20132655","journal-title":"Chin Med J (Engl)"},{"key":"5401_CR15","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1152\/physrev.00022.2018","volume":"99","author":"DP Del Re","year":"2019","unstructured":"Del Re DP, Amgalan D, Linkermann A, Liu Q, Kitsis RN (2019) Fundamental mechanisms of regulated cell death and implications for heart disease. Physiol Rev 99:1765\u20131817","journal-title":"Physiol Rev"},{"key":"5401_CR16","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1007\/s12011-016-0685-4","volume":"174","author":"J Wang","year":"2016","unstructured":"Wang J, Chen J, Tang Z, Li Y, Hu L, Pan J (2016) The effects of copper on brain microvascular endothelial cells and claudin via apoptosis and oxidative stress. Biol Trace Elem Res 174:132\u2013141","journal-title":"Biol Trace Elem Res"},{"key":"5401_CR17","first-page":"1825","volume":"50","author":"H Li","year":"2021","unstructured":"Li H, Li X, Cao T, Zhu Q, Liu F, Zhou H (2021) Effect of copper-containing stainless steel on apoptosis of coronary artery smooth muscle cells. Iran J Public Health 50:1825\u20131831","journal-title":"Iran J Public Health"},{"key":"5401_CR18","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/s41420-022-00870-4","volume":"8","author":"R Yin","year":"2022","unstructured":"Yin R, Wang H, Li C, Wang L, Lai S, Yang X, Hong D, Zhang W (2022) Induction of apoptosis and autosis in cardiomyocytes by the combination of homocysteine and copper via NOX-mediated p62 expression. Cell Death Discov 8:75\u201387","journal-title":"Cell Death Discov"},{"key":"5401_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.113329","volume":"234","author":"M Pan","year":"2022","unstructured":"Pan M, Cheng ZW, Huang CG, Ye ZQ, Sun LJ, Chen H, Fu BB, Zhou K, Fang ZR, Wang ZJ, Xiao QZ, Liu XS, Zhu FQ, Gao S (2022) Long-term exposure to copper induces mitochondria-mediated apoptosis in mouse hearts. Ecotoxicol Environ Saf 234:113329","journal-title":"Ecotoxicol Environ Saf"},{"key":"5401_CR20","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1007\/s12265-021-10128-6","volume":"14","author":"Y Xiao","year":"2021","unstructured":"Xiao Y, Song X, Wang T, Meng X, Feng Q, Li K, Kang YJ (2021) Copper preserves vasculature structure and function by protecting endothelial cells from apoptosis in ischemic myocardium. J Cardiovasc Transl Res 14:1146\u20131155","journal-title":"J Cardiovasc Transl Res"},{"issue":"17\u201320","key":"5401_CR21","first-page":"25","volume":"31","author":"L Xu","year":"2013","unstructured":"Xu L, Zhang Y, Yang K, Ren L, Wang Q (2013) Influence of copper-bearing stainless steel on adhesion, proliferation and apoptosis of vascular endothelial cell. Hua Xi Kou Qiang Yi Xue Za Zhi 31(17\u201320):25","journal-title":"Hua Xi Kou Qiang Yi Xue Za Zhi"},{"key":"5401_CR22","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1080\/15548627.2023.2200554","volume":"19","author":"Q Xue","year":"2023","unstructured":"Xue Q, Kang R, Klionsky DJ, Tang D, Liu J, Chen X (2023) Copper metabolism in cell death and autophagy. Autophagy 19:2175\u20132195","journal-title":"Autophagy"},{"key":"5401_CR23","doi-asserted-by":"publisher","first-page":"195","DOI":"10.14348\/molcells.2016.2198","volume":"39","author":"Y Seo","year":"2016","unstructured":"Seo Y, Cho YS, Huh YD, Park H (2016) Copper ion from Cu2O crystal induces AMPK-mediated autophagy via superoxide in endothelial cells. Mol Cells 39:195\u2013203","journal-title":"Mol Cells"},{"key":"5401_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2021.112040","volume":"213","author":"Q Li","year":"2021","unstructured":"Li Q, Liao J, Lei C, Shi J, Zhang H, Han Q, Guo J, Hu L, Li Y, Pan J, Tang Z (2021) Metabolomics analysis reveals the effect of copper on autophagy in myocardia of pigs. Ecotoxicol Environ Saf 213:112040","journal-title":"Ecotoxicol Environ Saf"},{"key":"5401_CR25","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01338-4","volume":"20","author":"Y Fan","year":"2022","unstructured":"Fan Y, Cheng Z, Mao L, Xu G, Li N, Zhang M, Weng P, Zheng L, Dong X, Hu S, Wang B, Qin X, Jiang X, Chen C, Zhang J, Zou Z (2022) PINK1\/TAX1BP1-directed mitophagy attenuates vascular endothelial injury induced by copper oxide nanoparticles. J Nanobiotechnology 20:149\u2013169","journal-title":"J Nanobiotechnology"},{"key":"5401_CR26","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1038\/s41586-023-06017-4","volume":"617","author":"S Solier","year":"2023","unstructured":"Solier S, M\u00fcller S, Ca\u00f1eque T, Versini A, Mansart A, Sindikubwabo F, Baron L, Emam L, Gestraud P, Panto\u0219 GD, Gandon V, Gaillet C, Wu TD, Dingli F, Loew D, Baulande S, Durand S, Sencio V, Robil C, Trottein F, P\u00e9ricat D, N\u00e4ser E, Cougoule C, Meunier E, B\u00e8gue AL, Salmon H, Manel N, Puisieux A, Watson S, Dawson MA, Servant N, Kroemer G, Annane D, Rodriguez R (2023) A druggable copper-signalling pathway that drives inflammation. Nature 617:386\u2013394","journal-title":"Nature"},{"key":"5401_CR27","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41346-y","volume":"14","author":"L Zhang","year":"2023","unstructured":"Zhang L, Yang P, Chen J, Chen Z, Liu Z, Feng G, Sha F, Li Z, Xu Z, Huang Y, Shi X, Li X, Cui J, Zhang C, Fan P, Cui L, Shen Y, Zhou G, Jing H, Ma S (2023) CD44 connects autophagy decline and ageing in the vascular endothelium. Nat Commun 14:5524","journal-title":"Nat Commun"},{"key":"5401_CR28","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1002\/jcp.22709","volume":"227","author":"YH Zheng","year":"2012","unstructured":"Zheng YH, Tian C, Meng Y, Qin YW, Du YH, Du J, Li HH (2012) Osteopontin stimulates autophagy via integrin\/CD44 and p38 MAPK signaling pathways in vascular smooth muscle cells. J Cell Physiol 227:127\u2013135","journal-title":"J Cell Physiol"},{"key":"5401_CR29","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1152\/physrev.00004.2006","volume":"87","author":"S Lutsenko","year":"2007","unstructured":"Lutsenko S, Barnes NL, Bartee MY, Dmitriev OY (2007) Function and regulation of human copper-transporting ATPases. Physiol Rev 87:1011\u20131046","journal-title":"Physiol Rev"},{"key":"5401_CR30","doi-asserted-by":"publisher","first-page":"3091","DOI":"10.1038\/s41467-021-23408-1","volume":"12","author":"D Ash","year":"2021","unstructured":"Ash D, Sudhahar V, Youn SW, Okur MN, Das A, O\u2019Bryan JP, McMenamin M, Hou Y, Kaplan JH, Fukai T, Ushio-Fukai M (2021) The P-type ATPase transporter ATP7A promotes angiogenesis by limiting autophagic degradation of VEGFR2. Nat Commun 12:3091","journal-title":"Nat Commun"},{"key":"5401_CR31","doi-asserted-by":"publisher","first-page":"H1237","DOI":"10.1152\/ajpheart.00559.2015","volume":"309","author":"M Leone","year":"2015","unstructured":"Leone M, Magadum A, Engel FB (2015) Cardiomyocyte proliferation in cardiac development and regeneration: a guide to methodologies and interpretations. Am J Physiol Heart Circ Physiol 309:H1237\u2013H1250","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"5401_CR32","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1258\/ebm.2011.011267","volume":"237","author":"S Li","year":"2012","unstructured":"Li S, Xie H, Li S, Kang YJ (2012) Copper stimulates growth of human umbilical vein endothelial cells in a vascular endothelial growth factor-independent pathway. Exp Biol Med (Maywood) 237:77\u201382","journal-title":"Exp Biol Med (Maywood)"},{"key":"5401_CR33","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1016\/j.biomaterials.2009.10.009","volume":"31","author":"C G\u00e9rard","year":"2010","unstructured":"G\u00e9rard C, Bordeleau LJ, Barralet J, Doillon CJ (2010) The stimulation of angiogenesis and collagen deposition by copper. Biomaterials 31:824\u2013831","journal-title":"Biomaterials"},{"key":"5401_CR34","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1006\/bbrc.1997.7018","volume":"236","author":"F Soncin","year":"1997","unstructured":"Soncin F, Guitton JD, Cartwright T, Badet J (1997) Interaction of human angiogenin with copper modulates angiogenin binding to endothelial cells. Biochem Biophys Res Commun 236:604\u2013610","journal-title":"Biochem Biophys Res Commun"},{"key":"5401_CR35","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1089\/ten.tea.2007.0370","volume":"15","author":"J Barralet","year":"2009","unstructured":"Barralet J, Gbureck U, Habibovic P, Vorndran E, Gerard C, Doillon CJ (2009) Angiogenesis in calcium phosphate scaffolds by inorganic copper ion release. Tissue Eng Part A 15:1601\u20131609","journal-title":"Tissue Eng Part A"},{"key":"5401_CR36","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.yjmcc.2008.03.022","volume":"45","author":"Y Zhou","year":"2008","unstructured":"Zhou Y, Jiang Y, Kang YJ (2008) Copper reverses cardiomyocyte hypertrophy through vascular endothelial growth factor-mediated reduction in the cell size. J Mol Cell Cardiol 45:106\u2013117","journal-title":"J Mol Cell Cardiol"},{"key":"5401_CR37","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/S1357-2725(02)00134-6","volume":"35","author":"PA Sharp","year":"2003","unstructured":"Sharp PA (2003) Ctr1 and its role in body copper homeostasis. Int J Biochem Cell Biol 35:288\u2013291","journal-title":"Int J Biochem Cell Biol"},{"key":"5401_CR38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071982","volume":"8","author":"G Narayanan","year":"2013","unstructured":"Narayanan G, R BS, Vuyyuru H, Muthuvel B, Konerirajapuram Natrajan S (2013) CTR1 silencing inhibits angiogenesis by limiting copper entry into endothelial cells. PLoS ONE 8:e71982","journal-title":"PLoS ONE"},{"key":"5401_CR39","doi-asserted-by":"publisher","first-page":"5357","DOI":"10.1074\/jbc.M113.529313","volume":"289","author":"M Tsuneki","year":"2014","unstructured":"Tsuneki M, Madri JA (2014) CD44 regulation of endothelial cell proliferation and apoptosis via modulation of CD31 and VE-cadherin expression. J Biol Chem 289:5357\u20135370","journal-title":"J Biol Chem"},{"key":"5401_CR40","doi-asserted-by":"publisher","first-page":"14780","DOI":"10.1038\/srep14780","volume":"5","author":"GF Chen","year":"2015","unstructured":"Chen GF, Sudhahar V, Youn SW, Das A, Cho J, Kamiya T, Urao N, McKinney RD, Surenkhuu B, Hamakubo T, Iwanari H, Li S, Christman JW, Shantikumar S, Angelini GD, Emanueli C, Ushio-Fukai M, Fukai T (2015) Copper transport protein antioxidant-1 promotes inflammatory neovascularization via chaperone and transcription factor function. Sci Rep 5:14780","journal-title":"Sci Rep"},{"key":"5401_CR41","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1080\/07853890.2017.1417631","volume":"50","author":"DA Chistiakov","year":"2018","unstructured":"Chistiakov DA, Shkurat TP, Melnichenko AA, Grechko AV, Orekhov AN (2018) The role of mitochondrial dysfunction in cardiovascular disease: a brief review. Ann Med 50:121\u2013127","journal-title":"Ann Med"},{"key":"5401_CR42","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1093\/jn\/122.7.1566","volume":"122","author":"J Davidson","year":"1992","unstructured":"Davidson J, Medeiros DM, Hamlin RL (1992) Cardiac ultrastructural and electrophysiological abnormalities in postweanling copper-restricted and copper-repleted rats in the absence of hypertrophy. J Nutr 122:1566\u20131575","journal-title":"J Nutr"},{"key":"5401_CR43","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1172\/JCI10268","volume":"106","author":"JJ Lehman","year":"2000","unstructured":"Lehman JJ, Barger PM, Kovacs A, Saffitz JE, Medeiros DM, Kelly DP (2000) Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J Clin Invest 106:847\u2013856","journal-title":"J Clin Invest"},{"key":"5401_CR44","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.jnutbio.2008.08.001","volume":"20","author":"DM Medeiros","year":"2009","unstructured":"Medeiros DM, Jiang Y, Klaahsen D, Lin D (2009) Mitochondrial and sarcoplasmic protein changes in hearts from copper-deficient rats: up-regulation of PGC-1alpha transcript and protein as a cause for mitochondrial biogenesis in copper deficiency. J Nutr Biochem 20:823\u2013830","journal-title":"J Nutr Biochem"},{"key":"5401_CR45","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1023\/A:1009274131473","volume":"11","author":"L Rossi","year":"1998","unstructured":"Rossi L, Lippe G, Marchese E, De Martino A, Mavelli I, Rotilio G, Ciriolo MR (1998) Decrease of cytochrome c oxidase protein in heart mitochondria of copper-deficient rats. Biometals 11:207\u2013212","journal-title":"Biometals"},{"key":"5401_CR46","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.jnutbio.2006.03.005","volume":"18","author":"WT Johnson","year":"2007","unstructured":"Johnson WT, Newman SM Jr. (2007) Hearts in adult offspring of copper-deficient dams exhibit decreased cytochrome c oxidase activity, increased mitochondrial hydrogen peroxide generation and enhanced formation of intracellular residual bodies. J Nutr Biochem 18:97\u2013104","journal-title":"J Nutr Biochem"},{"key":"5401_CR47","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1093\/jn\/121.6.815","volume":"121","author":"DM Medeiros","year":"1991","unstructured":"Medeiros DM, Bagby D, Ovecka G, McCormick R (1991) Myofibrillar, mitochondrial and valvular morphological alterations in cardiac hypertrophy among copper-deficient rats. J Nutr 121:815\u2013824","journal-title":"J Nutr"},{"key":"5401_CR48","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1203\/00006450-197005000-00003","volume":"4","author":"JR Goodman","year":"1970","unstructured":"Goodman JR, Warshaw JB, Dallman PR (1970) Cardiac hypertrophy in rats with iron and copper deficiency: quantitative contribution of mitochondrial enlargement. Pediatr Res 4:244\u2013256","journal-title":"Pediatr Res"},{"key":"5401_CR49","doi-asserted-by":"publisher","first-page":"127483","DOI":"10.1016\/j.jtemb.2024.127483","volume":"85","author":"T Wei","year":"2024","unstructured":"Wei T, Wang Q, Chen T, Zhou Z, Li S, Li Z, Zhang D (2024) The possible association of mitochondrial fusion and fission in copper deficiency-induced oxidative damage and mitochondrial dysfunction of the heart. J Trace Elem Med Biol 85:127483","journal-title":"J Trace Elem Med Biol"},{"key":"5401_CR50","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaf130","author":"B Tu","year":"2025","unstructured":"Tu B, Song K, Zhou ZY, Lin LC, Liu ZY, Sun H, Zhou Y, Sha JM, Shi Y, Yang JJ, Zhang Y, Zhao JY, Tao H (2025) Slc31a1 loss depletes mitochondrial copper and promotes cardiac fibrosis. Eur Heart J. https:\/\/doi.org\/10.1093\/eurheartj\/ehaf130","journal-title":"Eur Heart J"},{"key":"5401_CR51","doi-asserted-by":"publisher","first-page":"127549","DOI":"10.1016\/j.jtemb.2024.127549","volume":"86","author":"SM Guerra","year":"2024","unstructured":"Guerra SM, de Fran\u00e7a LC, da Silva KN, Grotto FS, Glaser V (2024) Copper dyshomeostasis and its relationship to AMPK activation, mitochondrial dynamics, and biogenesis of mitochondria: A systematic review of in vivo studies. J Trace Elem Med Biol 86:127549","journal-title":"J Trace Elem Med Biol"},{"key":"5401_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2022.109267","volume":"254","author":"MO Isei","year":"2022","unstructured":"Isei MO, Stevens D, Kamunde C (2022) Copper modulates heart mitochondrial H2O2 emission differently during fatty acid and pyruvate oxidation. Comp Biochem Physiol C Toxicol Pharmacol 254:109267","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"key":"5401_CR53","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1126\/science.abf0529","volume":"375","author":"P Tsvetkov","year":"2022","unstructured":"Tsvetkov P, Coy S, Petrova B, Dreishpoon M, Verma A, Abdusamad M, Rossen J, Joesch-Cohen L, Humeidi R, Spangler RD, Eaton JK, Frenkel E, Kocak M, Corsello SM, Lutsenko S, Kanarek N, Santagata S, Golub TR (2022) Copper induces cell death by targeting lipoylated TCA cycle proteins. Science 375:1254\u20131261","journal-title":"Science"},{"key":"5401_CR54","doi-asserted-by":"crossref","unstructured":"Sudhahar, V., Z. Xiao, A. Das, D. Ash, S. Yadav, C.D. Matier, A.T. Pezacki, B. Chatterjee, O.A. Antipova, S. Vogt, M. McMenamin, S. Kelley, G. Csanyi, J. Lee, H. Jo, C.J. Chang, J. Rao, J.H. Kaplan, M. Ushio-Fukai, and T. Fukai. (2025) Endothelial Cu uptake transporter CTR1 senses sisturbed flow to promote atherosclerosis through cuproptosis. bioRxiv.","DOI":"10.1101\/2025.01.27.634587"},{"key":"5401_CR55","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232112906","author":"MY Henein","year":"2022","unstructured":"Henein MY, Vancheri S, Longo G, Vancheri F (2022) The role of inflammation in cardiovascular disease. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms232112906","journal-title":"Int J Mol Sci"},{"key":"5401_CR56","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1097\/01.shk.0000068318.49350.3a","volume":"20","author":"D Bar-Or","year":"2003","unstructured":"Bar-Or D, Thomas GW, Yukl RL, Rael LT, Shimonkevitz RP, Curtis CG, Winkler JV (2003) Copper stimulates the synthesis and release of interleukin-8 in human endothelial cells: a possible early role in systemic inflammatory responses. Shock 20:154\u2013158","journal-title":"Shock"},{"key":"5401_CR57","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1007\/s10856-015-5454-y","volume":"26","author":"J Li","year":"2015","unstructured":"Li J, Ren L, Zhang S, Ren G, Yang K (2015) Cu-bearing steel reduce inflammation after stent implantation. J Mater Sci Mater Med 26:114\u2013117","journal-title":"J Mater Sci Mater Med"},{"key":"5401_CR58","doi-asserted-by":"publisher","first-page":"2320","DOI":"10.1161\/ATVBAHA.119.313374","volume":"39","author":"V Sudhahar","year":"2019","unstructured":"Sudhahar V, Das A, Horimatsu T, Ash D, Leanhart S, Antipova O, Vogt S, Singla B, Csanyi G, White J, Kaplan JH, Fulton D, Weintraub NL, Kim HW, Ushio-Fukai M, Fukai T (2019) Copper transporter ATP7A (copper-transporting P-type ATPase\/Menkes ATPase) limits vascular inflammation and aortic aneurysm development: role of microRNA-125b. Arterioscler Thromb Vasc Biol 39:2320\u20132337","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"5401_CR59","doi-asserted-by":"publisher","first-page":"764","DOI":"10.3390\/biomedicines10040764","volume":"10","author":"L D\u00edez-Tercero","year":"2022","unstructured":"D\u00edez-Tercero L, Delgado LM, Perez RA (2022) Modulation of macrophage response by copper and magnesium ions in combination with low concentrations of dexamethasone. Biomedicines 10:764\u2013779","journal-title":"Biomedicines"},{"key":"5401_CR60","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.jaci.2022.11.001","volume":"151","author":"A Long","year":"2023","unstructured":"Long A, Kleiner A, Looney RJ (2023) Immune dysregulation. J Allergy Clin Immunol 151:70\u201380","journal-title":"J Allergy Clin Immunol"},{"key":"5401_CR61","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1046\/j.1440-1711.2004.01231.x","volume":"82","author":"D Lominadze","year":"2004","unstructured":"Lominadze D, Saari JT, Percival SS, Schuschke DA (2004) Proinflammatory effects of copper deficiency on neutrophils and lung endothelial cells. Immunol Cell Biol 82:231\u2013238","journal-title":"Immunol Cell Biol"},{"key":"5401_CR62","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1007\/s12011-018-1472-1","volume":"189","author":"HJ Zhao","year":"2019","unstructured":"Zhao HJ, Zhao XH (2019) Modulatory effect of the supplemented copper ion on in vitro activity of bovine lactoferrin to murine splenocytes and RAW264.7 macrophages. Biol Trace Elem Res 189:519\u2013528","journal-title":"Biol Trace Elem Res"},{"key":"5401_CR63","first-page":"103","volume":"5","author":"BR Blakley","year":"1987","unstructured":"Blakley BR, Hamilton DL (1987) The effect of copper deficiency on the immune response in mice. Drug Nutr Interact 5:103\u2013111","journal-title":"Drug Nutr Interact"},{"key":"5401_CR64","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1111\/j.1753-4887.1993.tb03062.x","volume":"51","author":"BL O\u2019Dell","year":"1993","unstructured":"O\u2019Dell BL (1993) Interleukin-2 production is altered by copper deficiency. Nutr Rev 51:307\u2013309","journal-title":"Nutr Rev"},{"key":"5401_CR65","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1093\/jn\/121.5.745","volume":"121","author":"S Bala","year":"1991","unstructured":"Bala S, Failla ML, Lunney JK (1991) Alterations in splenic lymphoid cell subsets and activation antigens in copper-deficient rats. J Nutr 121:745\u2013753","journal-title":"J Nutr"},{"key":"5401_CR66","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114827","volume":"163","author":"H Tian","year":"2023","unstructured":"Tian H, Zhao X, Zhang Y, Xia Z (2023) Abnormalities of glucose and lipid metabolism in myocardial ischemia-reperfusion injury. Biomed Pharmacother 163:114827","journal-title":"Biomed Pharmacother"},{"key":"5401_CR67","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1007\/BF00968080","volume":"9","author":"JC Lai","year":"1984","unstructured":"Lai JC, Blass JP (1984) Neurotoxic effects of copper: inhibition of glycolysis and glycolytic enzymes. Neurochem Res 9:1699\u20131710","journal-title":"Neurochem Res"},{"key":"5401_CR68","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1111\/j.1574-6968.2001.tb10590.x","volume":"197","author":"S Gebhard","year":"2001","unstructured":"Gebhard S, Ronimus RS, Morgan HW (2001) Inhibition of phosphofructokinases by copper(II). FEMS Microbiol Lett 197:105\u2013109","journal-title":"FEMS Microbiol Lett"},{"key":"5401_CR69","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/s41401-021-00647-y","volume":"43","author":"SWS Leung","year":"2022","unstructured":"Leung SWS, Shi Y (2022) The glycolytic process in endothelial cells and its implications. Acta Pharmacol Sin 43:251\u2013259","journal-title":"Acta Pharmacol Sin"},{"key":"5401_CR70","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21113820","author":"JX Tang","year":"2020","unstructured":"Tang JX, Thompson K, Taylor RW, Ol\u00e1hov\u00e1 M (2020) Mitochondrial OXPHOS biogenesis: co-regulation of protein synthesis, import, and assembly pathways. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms21113820","journal-title":"Int J Mol Sci"},{"key":"5401_CR71","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1093\/jn\/124.6.789","volume":"124","author":"JC Chao","year":"1994","unstructured":"Chao JC, Medeiros DM, Davidson J, Shiry L (1994) Low levels of ATP synthase and cytochrome c oxidase subunit peptide from hearts of copper-deficient rats are not altered by the administration of dimethyl sulfoxide. J Nutr 124:789\u2013803","journal-title":"J Nutr"},{"key":"5401_CR72","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1093\/jn\/137.1.14","volume":"137","author":"H Zeng","year":"2007","unstructured":"Zeng H, Saari JT, Johnson WT (2007) Copper deficiency decreases complex IV but not complex I, II, III, or V in the mitochondrial respiratory chain in rat heart. J Nutr 137:14\u201318","journal-title":"J Nutr"},{"key":"5401_CR73","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101674","volume":"37","author":"D Nolfi-Donegan","year":"2020","unstructured":"Nolfi-Donegan D, Braganza A, Shiva S (2020) Mitochondrial electron transport chain: oxidative phosphorylation, oxidant production, and methods of measurement. Redox Biol 37:101674","journal-title":"Redox Biol"},{"key":"5401_CR74","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1111\/brv.12140","volume":"90","author":"A Stincone","year":"2015","unstructured":"Stincone A, Prigione A, Cramer T, Wamelink MM, Campbell K, Cheung E, Olin-Sandoval V, Gr\u00fcning NM, Kr\u00fcger A, Tauqeer Alam M, Keller MA, Breitenbach M, Brindle KM, Rabinowitz JD, Ralser M (2015) The return of metabolism: biochemistry and physiology of the pentose phosphate pathway. Biol Rev Camb Philos Soc 90:927\u2013963","journal-title":"Biol Rev Camb Philos Soc"},{"key":"5401_CR75","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.932154","volume":"13","author":"Q Meng","year":"2022","unstructured":"Meng Q, Zhang Y, Hao S, Sun H, Liu B, Zhou H, Wang Y, Xu ZX (2022) Recent findings in the regulation of G6PD and its role in diseases. Front Pharmacol 13:932154","journal-title":"Front Pharmacol"},{"key":"5401_CR76","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000083489.83704.76","volume":"93","author":"M Jain","year":"2003","unstructured":"Jain M, Brenner DA, Cui L, Lim CC, Wang B, Pimentel DR, Koh S, Sawyer DB, Leopold JA, Handy DE, Loscalzo J, Apstein CS, Liao R (2003) Glucose-6-phosphate dehydrogenase modulates cytosolic redox status and contractile phenotype in adult cardiomyocytes. Circ Res 93:e9","journal-title":"Circ Res"},{"key":"5401_CR77","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1001\/archinte.1967.04410010042005","volume":"120","author":"VF Fairbanks","year":"1967","unstructured":"Fairbanks VF (1967) Copper sulfate-induced hemolytic anemia. Inhibition of glucose-6-phosphate dehydrogenase and other possible etiologic mechanisms. Arch Intern Med 120:428\u2013432","journal-title":"Arch Intern Med"},{"key":"5401_CR78","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.tem.2022.02.001","volume":"33","author":"S Bhargava","year":"2022","unstructured":"Bhargava S, de la Puente-Secades S, Schurgers L, Jankowski J (2022) Lipids and lipoproteins in cardiovascular diseases: a classification. Trends Endocrinol Metab 33:409\u2013423","journal-title":"Trends Endocrinol Metab"},{"key":"5401_CR79","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2006519","volume":"16","author":"H Yang","year":"2018","unstructured":"Yang H, Ralle M, Wolfgang MJ, Dhawan N, Burkhead JL, Rodriguez S, Kaplan JH, Wong GW, Haughey N, Lutsenko S (2018) Copper-dependent amino oxidase 3 governs selection of metabolic fuels in adipocytes. PLoS Biol 16:e2006519","journal-title":"PLoS Biol"},{"key":"5401_CR80","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/0026-0495(90)90011-Z","volume":"39","author":"TP Carr","year":"1990","unstructured":"Carr TP, Lei KY (1990) High-density lipoprotein cholesteryl ester and protein catabolism in hypercholesterolemic rats induced by copper deficiency. Metabolism 39:518\u2013524","journal-title":"Metabolism"},{"key":"5401_CR81","doi-asserted-by":"publisher","first-page":"369","DOI":"10.3181\/00379727-212-44028","volume":"212","author":"JY Wu","year":"1996","unstructured":"Wu JY, Lei KY (1996) Copper deficiency increases total protein and apolipoprotein A-I synthesis in the rat small intestine. Proc Soc Exp Biol Med 212:369\u2013377","journal-title":"Proc Soc Exp Biol Med"},{"key":"5401_CR82","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12263-009-0153-2","volume":"5","author":"A Tosco","year":"2010","unstructured":"Tosco A, Fontanella B, Danise R, Cicatiello L, Grober OM, Ravo M, Weisz A, Marzullo L (2010) Molecular bases of copper and iron deficiency-associated dyslipidemia: a microarray analysis of the rat intestinal transcriptome. Genes Nutr 5:1\u20138","journal-title":"Genes Nutr"},{"key":"5401_CR83","doi-asserted-by":"publisher","first-page":"2178","DOI":"10.1093\/jn\/113.11.2178","volume":"113","author":"KY Lei","year":"1983","unstructured":"Lei KY (1983) Alterations in plasma lipid, lipoprotein and apolipoprotein concentrations in copper-deficient rats. J Nutr 113:2178\u20132183","journal-title":"J Nutr"},{"key":"5401_CR84","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1093\/jn\/122.6.1199","volume":"122","author":"AA al-Othman","year":"1992","unstructured":"al-Othman AA, Rosenstein F, Lei KY (1992) Copper deficiency alters plasma pool size, percent composition and concentration of lipoprotein components in rats. J Nutr 122:1199\u20131204","journal-title":"J Nutr"},{"key":"5401_CR85","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3181\/00379727-204-43640","volume":"204","author":"AA al-Othman","year":"1993","unstructured":"al-Othman AA, Rosenstein F, Lei KY (1993) Copper deficiency increases in vivo hepatic synthesis of fatty acids, triacylglycerols, and phospholipids in rats. Proc Soc Exp Biol Med 204:97\u2013103","journal-title":"Proc Soc Exp Biol Med"},{"key":"5401_CR86","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1016\/0026-0495(84)90096-9","volume":"33","author":"LM Klevay","year":"1984","unstructured":"Klevay LM, Inman L, Johnson LK, Lawler M, Mahalko JR, Milne DB, Lukaski HC, Bolonchuk W, Sandstead HH (1984) Increased cholesterol in plasma in a young man during experimental copper depletion. Metabolism 33:1112\u20131118","journal-title":"Metabolism"},{"key":"5401_CR87","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s10863-007-9101-2","volume":"39","author":"R Linz","year":"2007","unstructured":"Linz R, Lutsenko S (2007) Copper-transporting ATPases ATP7A and ATP7B: cousins, not twins. J Bioenerg Biomembr 39:403\u2013407","journal-title":"J Bioenerg Biomembr"},{"key":"5401_CR88","doi-asserted-by":"publisher","first-page":"8343","DOI":"10.1074\/jbc.M607496200","volume":"282","author":"D Huster","year":"2007","unstructured":"Huster D, Purnat TD, Burkhead JL, Ralle M, Fiehn O, Stuckert F, Olson NE, Teupser D, Lutsenko S (2007) High copper selectively alters lipid metabolism and cell cycle machinery in the mouse model of Wilson disease. J Biol Chem 282:8343\u20138355","journal-title":"J Biol Chem"},{"key":"5401_CR89","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.1007\/s00125-019-4966-2","volume":"62","author":"C Tao","year":"2019","unstructured":"Tao C, Wang Y, Zhao Y, Pan J, Fan Y, Liang X, Cao C, Zhao J, Petris MJ, Li K, Wang Y (2019) Adipocyte-specific disruption of ATPase copper transporting \u03b1 in mice accelerates lipoatrophy. Diabetologia 62:2340\u20132353","journal-title":"Diabetologia"},{"key":"5401_CR90","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1038\/nchembio.2098","volume":"12","author":"L Krishnamoorthy","year":"2016","unstructured":"Krishnamoorthy L, Cotruvo JA Jr, Chan J, Kaluarachchi H, Muchenditsi A, Pendyala VS, Jia S, Aron AT, Ackerman CM, Wal MN, Guan T, Smaga LP, Farhi SL, New EJ, Lutsenko S, Chang CJ (2016) Copper regulates cyclic-AMP-dependent lipolysis. Nat Chem Biol 12:586\u2013592","journal-title":"Nat Chem Biol"},{"key":"5401_CR91","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113188","volume":"142","author":"T Zeng","year":"2024","unstructured":"Zeng T, Lei GL, Yu ML, Zhang TY, Wang ZB, Wang SZ (2024) The role and mechanism of various trace elements in atherosclerosis. Int Immunopharmacol 142:113188","journal-title":"Int Immunopharmacol"},{"key":"5401_CR92","doi-asserted-by":"crossref","unstructured":"Sudhahar, V., Z. Xiao, A. Das, D. Ash, S. Yadav, C.D. Matier, A.T. Pezacki, B. Chatterjee, O.A. Antipova, S. Vogt, M. McMenamin, S. Kelley, G. Csanyi, J. Lee, H. Jo, C.J. Chang, J. Rao, J.H. Kaplan, M. Ushio-Fukai, and T. Fukai (2025) Endothelial Cu Uptake Transporter CTR1 Senses Disturbed Flow to Promote Atherosclerosis through Cuproptosis. bioRxiv.","DOI":"10.1101\/2025.01.27.634587"},{"key":"5401_CR93","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1194\/jlr.M003426","volume":"51","author":"Z Qin","year":"2010","unstructured":"Qin Z, Konaniah ES, Neltner B, Nemenoff RA, Hui DY, Weintraub NL (2010) Participation of ATP7A in macrophage mediated oxidation of LDL. J Lipid Res 51:1471\u20131477","journal-title":"J Lipid Res"},{"key":"5401_CR94","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s43556-023-00131-5","volume":"4","author":"Y Cui","year":"2023","unstructured":"Cui Y, Chen Y, Gan N, Li M, Liao W, Zhou Y, Xiang Q, Gong X, Guo Q, Hu P, Zheng XL, Shang D, Peng J, Tang Z (2023) A novel cuproptosis-related diagnostic gene signature and differential expression validation in atherosclerosis. Mol Biomed 4:21","journal-title":"Mol Biomed"},{"key":"5401_CR95","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1385\/BTER:78:1-3:179","volume":"78","author":"IM Hamilton","year":"2000","unstructured":"Hamilton IM, Gilmore WS, Strain JJ (2000) Marginal copper deficiency and atherosclerosis. Biol Trace Elem Res 78:179\u2013189","journal-title":"Biol Trace Elem Res"},{"key":"5401_CR96","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1139\/H08-091","volume":"33","author":"JC Falcone","year":"2008","unstructured":"Falcone JC, Lominadze D, Johnson WT, Schuschke DA (2008) Endothelial cell-derived nitric oxide mobilization is attenuated in copper-deficient rats. Appl Physiol Nutr Metab 33:1073\u20131078","journal-title":"Appl Physiol Nutr Metab"},{"key":"5401_CR97","doi-asserted-by":"publisher","first-page":"801","DOI":"10.2298\/VSP140417074T","volume":"72","author":"NM Tasi\u0107","year":"2015","unstructured":"Tasi\u0107 NM, Tasi\u0107 D, Ota\u0161evi\u0107 P, Veselinovi\u0107 M, Jakovljevi\u0107 V, Djuri\u0107 D, Radak D (2015) Copper and zinc concentrations in atherosclerotic plaque and serum in relation to lipid metabolism in patients with carotid atherosclerosis. Vojnosanit Pregl 72:801\u2013806","journal-title":"Vojnosanit Pregl"},{"key":"5401_CR98","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.033474","volume":"13","author":"D Zhou","year":"2024","unstructured":"Zhou D, Mao Q, Sun Y, Cheng H, Zhao J, Liu Q, Deng M, Xu S, Zhao X (2024) Association of blood copper with the subclinical carotid atherosclerosis: an observational study. J Am Heart Assoc 13:e033474","journal-title":"J Am Heart Assoc"},{"key":"5401_CR99","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1161\/01.ATV.0000124892.90999.cb","volume":"24","author":"N Stadler","year":"2004","unstructured":"Stadler N, Lindner RA, Davies MJ (2004) Direct detection and quantification of transition metal ions in human atherosclerotic plaques: evidence for the presence of elevated levels of iron and copper. Arterioscler Thromb Vasc Biol 24:949\u2013954","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"5401_CR100","doi-asserted-by":"publisher","first-page":"2662","DOI":"10.1021\/acs.nanolett.4c05348","volume":"25","author":"X Huang","year":"2025","unstructured":"Huang X, Zhou Y, Guo Y, Yan D, Sun P, Cao Y, Chen Y, Peng J (2025) Selenium-doped copper formate nanozymes with antisenescence and oxidative stress reduction for atherosclerosis treatment. Nano Lett 25:2662\u20132669","journal-title":"Nano Lett"},{"key":"5401_CR101","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1161\/CIRCRESAHA.118.313234","volume":"124","author":"E Brandsma","year":"2019","unstructured":"Brandsma E, Kloosterhuis NJ, Koster M, Dekker DC, Gijbels MJJ, van der Velden S, R\u00edos-Morales M, van Faassen MJR, Loreti MG, de Bruin A, Fu J, Kuipers F, Bakker BM, Westerterp M, de Winther MPJ, Hofker MH, van de Sluis B, Koonen DPY (2019) A proinflammatory gut microbiota increases systemic inflammation and accelerates atherosclerosis. Circ Res 124:94\u2013100","journal-title":"Circ Res"},{"key":"5401_CR102","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1111\/bcpt.13778","volume":"131","author":"E Song","year":"2022","unstructured":"Song E, Vu V, Varin TV, Botta A, Marette A, Sweeney G (2022) Copper fabric improves the metabolic profile of obese mice: potential role of the gut microbiota. Basic Clin Pharmacol Toxicol 131:355\u2013363","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"5401_CR103","doi-asserted-by":"publisher","first-page":"1409317","DOI":"10.3389\/fphar.2024.1409317","volume":"15","author":"G Peng","year":"2024","unstructured":"Peng G, Huang Y, Xie G, Tang J (2024) Exploring copper\u2019s role in stroke: progress and treatment approaches. Front Pharmacol 15:1409317","journal-title":"Front Pharmacol"},{"key":"5401_CR104","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1111\/cns.12427","volume":"21","author":"Y Jiang","year":"2015","unstructured":"Jiang Y, Wang LP, Dong XH, Cai J, Jiang GJ, Zhang C, Xie HH (2015) Trace amounts of copper in drinking water aggravate cerebral ischemic injury via impairing endothelial progenitor cells in mice. CNS Neurosci Ther 21:677\u2013680","journal-title":"CNS Neurosci Ther"},{"key":"5401_CR105","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1007\/s12011-021-02742-x","volume":"200","author":"J Xu","year":"2022","unstructured":"Xu J, Xu G, Fang J (2022) Association between serum copper and stroke risk factors in adults: evidence from the national health and nutrition examination survey, 2011\u20132016. Biol Trace Elem Res 200:1089\u20131094","journal-title":"Biol Trace Elem Res"},{"key":"5401_CR106","doi-asserted-by":"publisher","first-page":"409","DOI":"10.3390\/nu14030409","volume":"14","author":"L Yang","year":"2022","unstructured":"Yang L, Chen X, Cheng H, Zhang L (2022) Dietary copper intake and risk of stroke in adults: a case-control study based on national health and nutrition examination survey 2013\u20132018. Nutrients 14:409\u2013412","journal-title":"Nutrients"},{"key":"5401_CR107","doi-asserted-by":"publisher","first-page":"333","DOI":"10.3389\/fneur.2018.00333","volume":"9","author":"R Squitti","year":"2018","unstructured":"Squitti R, Siotto M, Assenza G, Giannantoni NM, Rongioletti M, Zappasodi F, Tecchio F (2018) Prognostic value of serum copper for post-stroke clinical recovery: a pilot study. Front Neurol 9:333\u2013339","journal-title":"Front Neurol"},{"issue":"17","key":"5401_CR108","doi-asserted-by":"publisher","first-page":"2139","DOI":"10.3390\/nu13072139","volume":"13","author":"A Miro\u0144czuk","year":"2021","unstructured":"Miro\u0144czuk A, Kapica-Topczewska K, Socha K, Soroczy\u0144ska J, Jamio\u0142kowski J, Ku\u0142akowska A, Kochanowicz J (2021) Selenium, Copper, Zinc Concentrations and Cu\/Zn, Cu\/Se Molar Ratios in the Serum of Patients with Acute Ischemic Stroke in Northeastern Poland-A New Insight into Stroke Pathophysiology. Nutrients 13(17):2139","journal-title":"Nutrients"},{"key":"5401_CR109","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1161\/HYPERTENSIONAHA.119.14240","volume":"75","author":"FD Fuchs","year":"2020","unstructured":"Fuchs FD, Whelton PK (2020) High blood pressure and cardiovascular disease. Hypertension 75:285\u2013292","journal-title":"Hypertension"},{"key":"5401_CR110","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/0090-6980(88)90121-9","volume":"35","author":"LL Mitchell","year":"1988","unstructured":"Mitchell LL, Allen KG, Mathias MM (1988) Copper deficiency depresses rat aortae superoxide dismutase activity and prostacyclin synthesis. Prostaglandins 35:977\u2013986","journal-title":"Prostaglandins"},{"key":"5401_CR111","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/BF03032673","volume":"29","author":"HF Loyke","year":"1991","unstructured":"Loyke HF (1991) Copper and zinc in experimental hypertension. Biol Trace Elem Res 29:45\u201349","journal-title":"Biol Trace Elem Res"},{"key":"5401_CR112","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1093\/jn\/135.1.92","volume":"135","author":"PG Reeves","year":"2005","unstructured":"Reeves PG, Demars LC, Johnson WT, Lukaski HC (2005) Dietary copper deficiency reduces iron absorption and duodenal enterocyte hephaestin protein in male and female rats. J Nutr 135:92\u201398","journal-title":"J Nutr"},{"key":"5401_CR113","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s12011-010-8650-0","volume":"139","author":"J Suliburska","year":"2011","unstructured":"Suliburska J, Bogda\u0144ski P, Pupek-Musialik D, Krejpcio Z (2011) Dietary intake and serum and hair concentrations of minerals and their relationship with serum lipids and glucose levels in hypertensive and obese patients with insulin resistance. Biol Trace Elem Res 139:137\u2013150","journal-title":"Biol Trace Elem Res"},{"key":"5401_CR114","doi-asserted-by":"crossref","unstructured":"Gokhale, N.H. and J.A. Cowan (2005) Inactivation of human angiotensin converting enzyme by copper peptide complexes containing ATCUN motifs. Chem Commun (Camb). 5916\u20135918.","DOI":"10.1039\/b511081e"},{"key":"5401_CR115","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1161\/HYPERTENSIONAHA.108.116467","volume":"52","author":"Z Qin","year":"2008","unstructured":"Qin Z, Gongora MC, Ozumi K, Itoh S, Akram K, Ushio-Fukai M, Harrison DG, Fukai T (2008) Role of Menkes ATPase in angiotensin II-induced hypertension: a key modulator for extracellular superoxide dismutase function. Hypertension 52:945\u2013951","journal-title":"Hypertension"},{"key":"5401_CR116","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.1007\/s10495-024-02021-9","volume":"29","author":"YF Chen","year":"2024","unstructured":"Chen YF, Qi RQ, Song JW, Wang SY, Dong ZJ, Chen YH, Liu Y, Zhou XY, Li J, Liu XY, Zhong JC (2024) Sirtuin 7 ameliorates cuproptosis, myocardial remodeling and heart dysfunction in hypertension through the modulation of YAP\/ATP7A signaling. Apoptosis 29:2161\u20132182","journal-title":"Apoptosis"},{"key":"5401_CR117","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1007\/s12603-022-1787-7","volume":"26","author":"H Gong","year":"2022","unstructured":"Gong H, Yu Q, Yuan M, Jiang Y, Wang J, Huang P, Zhou J (2022) The relationship between dietary copper intake and telomere length in hypertension. J Nutr Health Aging 26:510\u2013514","journal-title":"J Nutr Health Aging"},{"key":"5401_CR118","first-page":"432","volume":"50","author":"Y Wang","year":"2025","unstructured":"Wang Y, Sun Y, Jie T, Wang M, Zhang S, Yang H, Jian W, Dai D, Xu R, Yue B, Qu X (2025) Association between serum copper-zinc-selenium mixture and multiple health outcomes. Bioact Mater 50:432\u2013442","journal-title":"Bioact Mater"},{"key":"5401_CR119","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.116064","volume":"272","author":"P Liu","year":"2024","unstructured":"Liu P, Liu Y, Cheng J, Xia Y, Yang Y (2024) Copper exposure causes alteration in the intestinal microbiota and metabolites in Takifugu rubripes. Ecotoxicol Environ Saf 272:116064","journal-title":"Ecotoxicol Environ Saf"},{"key":"5401_CR120","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1161\/CIRCULATIONAHA.116.024545","volume":"135","author":"FZ Marques","year":"2017","unstructured":"Marques FZ, Nelson E, Chu PY, Horlock D, Fiedler A, Ziemann M, Tan JK, Kuruppu S, Rajapakse NW, El-Osta A, Mackay CR, Kaye DM (2017) High-fiber diet and acetate supplementation change the gut microbiota and prevent the development of hypertension and heart failure in hypertensive mice. Circulation 135:964\u2013977","journal-title":"Circulation"},{"key":"5401_CR121","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1089963","volume":"10","author":"AK Bajpai","year":"2023","unstructured":"Bajpai AK, Gu Q, Orgil BO, Xu F, Torres-Rojas C, Zhao W, Chen C, Starlard-Davenport A, Jones B, Lebeche D, Towbin JA, Purevjav E, Lu L, Zhang W (2023) Cardiac copper content and its relationship with heart physiology: insights based on quantitative genetic and functional analyses using BXD family mice. Front Cardiovasc Med 10:1089963","journal-title":"Front Cardiovasc Med"},{"key":"5401_CR122","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.jnutbio.2008.06.007","volume":"20","author":"Z Zhou","year":"2009","unstructured":"Zhou Z, Johnson WT, Kang YJ (2009) Regression of copper-deficient heart hypertrophy: reduction in the size of hypertrophic cardiomyocytes. J Nutr Biochem 20:621\u2013628","journal-title":"J Nutr Biochem"},{"key":"5401_CR123","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/BF02783334","volume":"64","author":"S Mao","year":"1998","unstructured":"Mao S, Medeiros DM, Wildman RE (1998) Cardiac hypertrophy in copper-deficient rats is owing to increased mitochondria. Biol Trace Elem Res 64:175\u2013184","journal-title":"Biol Trace Elem Res"},{"key":"5401_CR124","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1007\/s12012-009-9043-5","volume":"9","author":"V Ansteinsson","year":"2009","unstructured":"Ansteinsson V, Refsnes M, Skomedal T, Osnes JB, Schiander I, L\u00e5g M (2009) Zinc- and copper-induced interleukin-6 release in primary cell cultures from rat heart. Cardiovasc Toxicol 9:86\u201394","journal-title":"Cardiovasc Toxicol"},{"key":"5401_CR125","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1084\/jem.20061943","volume":"204","author":"Y Jiang","year":"2007","unstructured":"Jiang Y, Reynolds C, Xiao C, Feng W, Zhou Z, Rodriguez W, Tyagi SC, Eaton JW, Saari JT, Kang YJ (2007) Dietary copper supplementation reverses hypertrophic cardiomyopathy induced by chronic pressure overload in mice. J Exp Med 204:657\u2013666","journal-title":"J Exp Med"},{"key":"5401_CR126","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.cmet.2010.04.003","volume":"11","author":"BE Kim","year":"2010","unstructured":"Kim BE, Turski ML, Nose Y, Casad M, Rockman HA, Thiele DJ (2010) Cardiac copper deficiency activates a systemic signaling mechanism that communicates with the copper acquisition and storage organs. Cell Metab 11:353\u2013363","journal-title":"Cell Metab"},{"key":"5401_CR127","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1385\/BTER:95:1:11","volume":"95","author":"G Topuzoglu","year":"2003","unstructured":"Topuzoglu G, Erbay AR, Karul AB, Yensel N (2003) Concentrations of copper, zinc, and magnesium in sera from patients with idiopathic dilated cardiomyopathy. Biol Trace Elem Res 95:11\u201317","journal-title":"Biol Trace Elem Res"},{"key":"5401_CR128","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/BF02790067","volume":"46","author":"RE Wildman","year":"1994","unstructured":"Wildman RE, Medeiros DM, Jenkins J (1994) Comparative aspects of cardiac ultrastructure, morphometry, and electrocardiography of hearts from rats fed restricted dietary copper and selenium. Biol Trace Elem Res 46:51\u201366","journal-title":"Biol Trace Elem Res"},{"key":"5401_CR129","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.116718","volume":"282","author":"YQ Xia","year":"2024","unstructured":"Xia YQ, Yang Y, Liu Y, Li CH, Liu PF (2024) Investigation of copper-induced intestinal damage and proteome alterations in Takifugu rubripes: potential health risks and environmental toxicology detection. Ecotoxicol Environ Saf 282:116718","journal-title":"Ecotoxicol Environ Saf"},{"key":"5401_CR130","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1038\/s41467-022-29060-7","volume":"13","author":"M Zhao","year":"2022","unstructured":"Zhao M, Wei H, Li C, Zhan R, Liu C, Gao J, Yi Y, Cui X, Shan W, Ji L, Pan B, Cheng S, Song M, Sun H, Jiang H, Cai J, Garcia-Barrio MT, Chen YE, Meng X, Dong E, Wang DW, Zheng L (2022) Gut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy. Nat Commun 13:1757","journal-title":"Nat Commun"},{"key":"5401_CR131","doi-asserted-by":"publisher","first-page":"1527901","DOI":"10.3389\/fphar.2024.1527901","volume":"15","author":"Z Liu","year":"2024","unstructured":"Liu Z, Gan Y, Shen Z, Cai S, Wang X, Li Y, Li X, Fu H, Chen J, Li N (2024) Role of copper homeostasis and cuproptosis in heart failure pathogenesis: implications for therapeutic strategies. Front Pharmacol 15:1527901","journal-title":"Front Pharmacol"},{"key":"5401_CR132","doi-asserted-by":"publisher","first-page":"190","DOI":"10.2174\/187152511797037583","volume":"9","author":"S Abdalla","year":"2011","unstructured":"Abdalla S, Fu X, Elzahwy SS, Klaetschke K, Streichert T, Quitterer U (2011) Up-regulation of the cardiac lipid metabolism at the onset of heart failure. Cardiovasc Hematol Agents Med Chem 9:190\u2013206","journal-title":"Cardiovasc Hematol Agents Med Chem"},{"key":"5401_CR133","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1039\/c9mt00223e","volume":"12","author":"S Zhang","year":"2020","unstructured":"Zhang S, Liu H, Amarsingh GV, Cheung CCH, Wu D, Narayanan U, Zhang L, Cooper GJS (2020) Restoration of myocellular copper-trafficking proteins and mitochondrial copper enzymes repairs cardiac function in rats with diabetes-evoked heart failure. Metallomics 12:259\u2013272","journal-title":"Metallomics"},{"key":"5401_CR134","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1177\/15353702-0322807-06","volume":"228","author":"L Elsherif","year":"2003","unstructured":"Elsherif L, Ortines RV, Saari JT, Kang YJ (2003) Congestive heart failure in copper-deficient mice. Exp Biol Med (Maywood) 228:811\u2013817","journal-title":"Exp Biol Med (Maywood)"},{"key":"5401_CR135","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s12012-008-9021-3","volume":"8","author":"WM Hughes Jr","year":"2008","unstructured":"Hughes WM Jr, Rodriguez WE, Rosenberger D, Chen J, Sen U, Tyagi N, Moshal KS, Vacek T, Kang YJ, Tyagi SC (2008) Role of copper and homocysteine in pressure overload heart failure. Cardiovasc Toxicol 8:137\u2013144","journal-title":"Cardiovasc Toxicol"},{"key":"5401_CR136","first-page":"753","volume":"47","author":"F M\u00e1lek","year":"2001","unstructured":"M\u00e1lek F, Spacek R, Pol\u00e1sek R, Karel L, Stanka P, Zen\u00e1hl\u00edkov\u00e1 M, Jiresov\u00e1 E (2001) Serum copper levels in patients with chronic heart failure associated with systolic left ventricular dysfunction and its relation to the severity of cardiac failure. Vnitr Lek 47:753\u2013756","journal-title":"Vnitr Lek"},{"key":"5401_CR137","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1007\/s00392-014-0735-x","volume":"103","author":"I Alexanian","year":"2014","unstructured":"Alexanian I, Parissis J, Farmakis D, Athanaselis S, Pappas L, Gavrielatos G, Mihas C, Paraskevaidis I, Sideris A, Kremastinos D, Spiliopoulou C, Anastasiou-Nana M, Lekakis J, Filippatos G (2014) Clinical and echocardiographic correlates of serum copper and zinc in acute and chronic heart failure. Clin Res Cardiol 103:938\u2013949","journal-title":"Clin Res Cardiol"},{"key":"5401_CR138","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1016\/j.numecd.2022.05.005","volume":"32","author":"SK Kunutsor","year":"2022","unstructured":"Kunutsor SK, Voutilainen A, Kurl S, Laukkanen JA (2022) Serum copper-to-zinc ratio is associated with heart failure and improves risk prediction in middle-aged and older Caucasian men: A prospective study. Nutr Metab Cardiovasc Dis 32:1924\u20131935","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"5401_CR139","first-page":"216","volume":"6","author":"F Ko\u015far","year":"2006","unstructured":"Ko\u015far F, Sahin I, Ta\u015fkapan C, K\u00fc\u00e7\u00fckbay Z, G\u00fcll\u00fc H, Ta\u015fkapan H, Cehreli S (2006) Trace element status (Se, Zn, Cu) in heart failure. Anadolu Kardiyol Derg 6:216\u2013220","journal-title":"Anadolu Kardiyol Derg"},{"key":"5401_CR140","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.122.009972","volume":"16","author":"KA Romano","year":"2023","unstructured":"Romano KA, Nemet I, Prasad Saha P, Haghikia A, Li XS, Mohan ML, Lovano B, Castel L, Witkowski M, Buffa JA, Sun Y, Li L, Menge CM, Demuth I, K\u00f6nig M, Steinhagen-Thiessen E, DiDonato JA, Deb A, B\u00e4ckhed F, Tang WHW, Naga Prasad SV, Landmesser U, Van Wagoner DR, Hazen SL (2023) Gut microbiota-generated phenylacetylglutamine and heart failure. Circ Heart Fail 16:e009972","journal-title":"Circ Heart Fail"},{"key":"5401_CR141","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01688-x","volume":"9","author":"M Zhang","year":"2024","unstructured":"Zhang M, Liu Q, Meng H, Duan H, Liu X, Wu J, Gao F, Wang S, Tan R, Yuan J (2024) Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets. Signal Transduct Target Ther 9:12","journal-title":"Signal Transduct Target Ther"},{"key":"5401_CR142","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1039\/C5MT00332F","volume":"8","author":"W Zhang","year":"2016","unstructured":"Zhang W, Zhao X, Xiao Y, Chen J, Han P, Zhang J, Fu H, Kang YJ (2016) The association of depressed angiogenic factors with reduced capillary density in the rhesus monkey model of myocardial ischemia. Metallomics 8:654\u2013662","journal-title":"Metallomics"},{"key":"5401_CR143","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1161\/01.RES.69.3.881","volume":"69","author":"SR Powell","year":"1991","unstructured":"Powell SR, Hall D, Shih A (1991) Copper loading of hearts increases postischemic reperfusion injury. Circ Res 69:881\u2013885","journal-title":"Circ Res"},{"key":"5401_CR144","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2023.2209735","volume":"55","author":"Q Guo","year":"2023","unstructured":"Guo Q, Ma M, Yu H, Han Y, Zhang D (2023) Dexmedetomidine enables copper homeostasis in cerebral ischemia\/reperfusion via ferredoxin 1. Ann Med 55:2209735","journal-title":"Ann Med"},{"key":"5401_CR145","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-48227-y","volume":"15","author":"N Chen","year":"2024","unstructured":"Chen N, Guo L, Wang L, Dai S, Zhu X, Wang E (2024) Sleep fragmentation exacerbates myocardial ischemia-reperfusion injury by promoting copper overload in cardiomyocytes. Nat Commun 15:3834","journal-title":"Nat Commun"},{"key":"5401_CR146","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2025.111387","volume":"408","author":"X Liu","year":"2025","unstructured":"Liu X, Liu H, Wang N, Lai S, Qiu C, Gao S, Huang T, Zhang W (2025) The interactive toxic effect of homocysteine and copper on cardiac microvascular endothelial cells during ischemia-reperfusion injury. Chem Biol Interact 408:111387","journal-title":"Chem Biol Interact"},{"key":"5401_CR147","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000138390.81640.54","volume":"110","author":"M Tanaka","year":"2004","unstructured":"Tanaka M, Mokhtari GK, Terry RD, Balsam LB, Lee KH, Kofidis T, Tsao PS, Robbins RC (2004) Overexpression of human copper\/zinc superoxide dismutase (SOD1) suppresses ischemia-reperfusion injury and subsequent development of graft coronary artery disease in murine cardiac grafts. Circulation 110:Ii200-6","journal-title":"Circulation"},{"key":"5401_CR148","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1093\/cvr\/cvad023","volume":"119","author":"J Zhao","year":"2023","unstructured":"Zhao J, Zhang Q, Cheng W, Dai Q, Wei Z, Guo M, Chen F, Qiao S, Hu J, Wang J, Chen H, Bao X, Mu D, Sun X, Xu B, Xie J (2023) Heart-gut microbiota communication determines the severity of cardiac injury after myocardial ischaemia\/reperfusion. Cardiovasc Res 119:1390\u20131402","journal-title":"Cardiovasc Res"},{"key":"5401_CR149","doi-asserted-by":"publisher","first-page":"e2401527","DOI":"10.1002\/advs.202401527","volume":"11","author":"X Hong","year":"2024","unstructured":"Hong X, Tian G, Dai B, Zhou X, Gao Y, Zhu L, Liu H, Zhu Q, Zhang L, Zhu Y, Ren D, Guo C, Nan J, Liu X, Wang J, Ren T (2024) Copper-loaded Milk-Protein Derived Microgel Preserves Cardiac Metabolic Homeostasis After Myocardial Infarction. Adv Sci (Weinh) 11:e2401527","journal-title":"Adv Sci (Weinh)"},{"key":"5401_CR150","doi-asserted-by":"publisher","first-page":"237","DOI":"10.3109\/08958378.2015.1030480","volume":"27","author":"A Chen","year":"2015","unstructured":"Chen A, Li G, Liu Y (2015) Association between copper levels and myocardial infarction: a meta-analysis. Inhal Toxicol 27:237\u2013246","journal-title":"Inhal Toxicol"},{"key":"5401_CR151","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.cca.2007.12.004","volume":"389","author":"TG Kazi","year":"2008","unstructured":"Kazi TG, Afridi HI, Kazi N, Jamali MK, Arain MB, Sarfraz RA, Jalbani N, Ansari R, Shah AQ, Memon AU, Khandhro GA (2008) Distribution of zinc, copper and iron in biological samples of Pakistani myocardial infarction (1st, 2nd and 3rd heart attack) patients and controls. Clin Chim Acta 389:114\u2013119","journal-title":"Clin Chim Acta"},{"key":"5401_CR152","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.pharep.2018.02.023","volume":"70","author":"AK Sharma","year":"2018","unstructured":"Sharma AK, Kumar A, Taneja G, Nagaich U, Deep A, Datusalia AK, Rajput SK (2018) Combined and individual strategy of exercise generated preconditioning and low dose copper nanoparticles serve as superlative approach to ameliorate ISO-induced myocardial infarction in rats. Pharmacol Rep 70:789\u2013795","journal-title":"Pharmacol Rep"},{"key":"5401_CR153","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.mvr.2018.06.003","volume":"120","author":"AK Sharma","year":"2018","unstructured":"Sharma AK, Kumar A, Sahu M, Sharma G, Datusalia AK, Rajput SK (2018) Exercise preconditioning and low dose copper nanoparticles exhibits cardioprotection through targeting GSK-3\u03b2 phosphorylation in ischemia\/reperfusion induced myocardial infarction. Microvasc Res 120:59\u201366","journal-title":"Microvasc Res"},{"key":"5401_CR154","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1177\/1535370220969844","volume":"246","author":"C Li","year":"2021","unstructured":"Li C, Wang T, Xiao Y, Li K, Meng X, James Kang Y (2021) COMMD1 upregulation is involved in copper efflux from ischemic hearts. Exp Biol Med (Maywood) 246:607\u2013616","journal-title":"Exp Biol Med (Maywood)"},{"key":"5401_CR155","doi-asserted-by":"publisher","first-page":"409","DOI":"10.3389\/fcvm.2022.942000","volume":"9","author":"H Wen","year":"2022","unstructured":"Wen H, Niu X, Hu L, Sun N, Zhao R, Wang Q, Li Y (2022) Dietary copper intake and risk of myocardial infarction in US adults: a propensity score-matched analysis. Front Cardiovasc Med 9:409\u2013412","journal-title":"Front Cardiovasc Med"},{"key":"5401_CR156","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.jgg.2021.12.007","volume":"49","author":"C Liu","year":"2022","unstructured":"Liu C, Sun Z, Shali S, Mei Z, Chang S, Mo H, Xu L, Pu Y, Guan H, Chen GC, Qi Q, Quan Z, Qi J, Yao K, Dai Y, Zheng Y, Ge J (2022) The gut microbiome and microbial metabolites in acute myocardial infarction. J Genet Genomics 49:569\u2013578","journal-title":"J Genet Genomics"},{"key":"5401_CR157","unstructured":"Longo DL, F.A., Kasper DL, Hauser SL, Jameson JL, Loscalzo J (2012) Harrison\u2019s Principles of Internal Medicine. New York: McGraw-Hill."},{"key":"5401_CR158","unstructured":"Bender DA, B.K., Weil PA, Kennelly PJ, Murray RK, Rodwell VW (2011) Harper\u2019s Illustrated Biochemistry. New York: McGraw-Hill."},{"key":"5401_CR159","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.clinbiochem.2020.05.002","volume":"82","author":"KL Johnson-Davis","year":"2020","unstructured":"Johnson-Davis KL, Farnsworth C, Law C, Parker R (2020) Method validation for a multi-element panel in serum by inductively coupled plasma mass spectrometry (ICP-MS). Clin Biochem 82:90\u201398","journal-title":"Clin Biochem"},{"key":"5401_CR160","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1177\/0004563218793163","volume":"56","author":"J Jeffery","year":"2019","unstructured":"Jeffery J, Frank AR, Hockridge S, Stosnach H, Costelloe SJ (2019) Method for measurement of serum copper, zinc and selenium using total reflection X-ray fluorescence spectroscopy on the PICOFOX analyser: validation and comparison with atomic absorption spectroscopy and inductively coupled plasma mass spectrometry. Ann Clin Biochem 56:170\u2013178","journal-title":"Ann Clin Biochem"},{"key":"5401_CR161","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s41181-022-00171-2","volume":"7","author":"N AlHokbany","year":"2022","unstructured":"AlHokbany N, AlJammaz I, AlOtaibi B, AlMalki Y, AlJammaz B, Okarvi SM (2022) Development of new copper-64 labeled rhodamine: a potential PET myocardial perfusion imaging agent. EJNMMI Radiopharm Chem 7:19","journal-title":"EJNMMI Radiopharm Chem"},{"key":"5401_CR162","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1073\/pnas.0607238104","volume":"104","author":"L Finney","year":"2007","unstructured":"Finney L, Mandava S, Ursos L, Zhang W, Rodi D, Vogt S, Legnini D, Maser J, Ikpatt F, Olopade OI, Glesne D (2007) X-ray fluorescence microscopy reveals large-scale relocalization and extracellular translocation of cellular copper during angiogenesis. Proc Natl Acad Sci U S A 104:2247\u20132252","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5401_CR163","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1039\/c1mt00033k","volume":"3","author":"Z Qin","year":"2011","unstructured":"Qin Z, Toursarkissian B, Lai B (2011) Synchrotron radiation x-ray fluorescence microscopy reveals a spatial association of copper on elastic laminae in rat aortic media. Metallomics 3:823\u2013828","journal-title":"Metallomics"},{"key":"5401_CR164","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s13619-023-00170-x","volume":"12","author":"Y Chen","year":"2023","unstructured":"Chen Y, Du J, Zheng L, Wang Z, Zhang Z, Wu Z, Zhu X, Xiong JW (2023) Chemical screening links disulfiram with cardiac protection after ischemic injury. Cell Regen 12:25\u201335","journal-title":"Cell Regen"},{"key":"5401_CR165","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12030524","author":"J Lanz","year":"2023","unstructured":"Lanz J, Biniaz-Harris N, Kuvaldina M, Jain S, Lewis K, Fallon BA (2023) Disulfiram: Mechanisms, applications, and challenges. Antibiotics. https:\/\/doi.org\/10.3390\/antibiotics12030524","journal-title":"Antibiotics"},{"key":"5401_CR166","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.atherosclerosis.2012.06.013","volume":"223","author":"H Wei","year":"2012","unstructured":"Wei H, Zhang WJ, McMillen TS, Leboeuf RC, Frei B (2012) Copper chelation by tetrathiomolybdate inhibits vascular inflammation and atherosclerotic lesion development in apolipoprotein E-deficient mice. Atherosclerosis 223:306\u2013313","journal-title":"Atherosclerosis"},{"key":"5401_CR167","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002310","volume":"14","author":"A Dyson","year":"2017","unstructured":"Dyson A, Dal-Pizzol F, Sabbatini G, Lach AB, Galfo F, Dos Santos Cardoso J, Pescador Mendon\u00e7a B, Hargreaves I, Bollen Pinto B, Bromage DI, Martin JF, Moore KP, Feelisch M, Singer M (2017) Ammonium tetrathiomolybdate following ischemia\/reperfusion injury: chemistry, pharmacology, and impact of a new class of sulfide donor in preclinical injury models. PLoS Med 14:e1002310","journal-title":"PLoS Med"},{"key":"5401_CR168","doi-asserted-by":"publisher","first-page":"445","DOI":"10.2460\/ajvr.76.5.445","volume":"76","author":"CM Chan","year":"2015","unstructured":"Chan CM, Langlois DK, Buchweitz JP, Lehner AF, Olivier NB, Herdt TH, Bailie MB, Schall WD (2015) Pharmacologic evaluation of ammonium tetrathiomolybdate after intravenous and oral administration to healthy dogs. Am J Vet Res 76:445\u2013453","journal-title":"Am J Vet Res"},{"key":"5401_CR169","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1124\/mol.106.028605","volume":"70","author":"D Gong","year":"2006","unstructured":"Gong D, Lu J, Chen X, Choong SY, Zhang S, Chan YK, Glyn-Jones S, Gamble GD, Phillips AR, Cooper GJ (2006) Molecular changes evoked by triethylenetetramine treatment in the extracellular matrix of the heart and aorta in diabetic rats. Mol Pharmacol 70:2045\u20132051","journal-title":"Mol Pharmacol"},{"key":"5401_CR170","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1177\/0091270009349379","volume":"50","author":"J Lu","year":"2010","unstructured":"Lu J, Poppitt SD, Othman AA, Sunderland T, Ruggiero K, Willett MS, Diamond LE, Garcia WD, Roesch BG, Cooper GJ (2010) Pharmacokinetics, pharmacodynamics, and metabolism of triethylenetetramine in healthy human participants: an open-label trial. J Clin Pharmacol 50:647\u2013658","journal-title":"J Clin Pharmacol"},{"key":"5401_CR171","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5213532","volume":"2016","author":"M \u0158\u00edha","year":"2016","unstructured":"\u0158\u00edha M, Ha\u0161kov\u00e1 P, Martin J, Filipsk\u00fd T, V\u00e1\u0148ov\u00e1 K, V\u00e1vrov\u00e1 J, Hole\u010dkov\u00e1 M, Homola P, V\u00edtek L, Palicka V, \u0160im\u016fnek T, Mlad\u011bnka P (2016) Protective effects of D-penicillamine on catecholamine-induced myocardial injury. Oxid Med Cell Longev 2016:5213532","journal-title":"Oxid Med Cell Longev"},{"key":"5401_CR172","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1002\/bdd.2510070410","volume":"7","author":"A Ifan","year":"1986","unstructured":"Ifan A, Welling PG (1986) Pharmacokinetics of oral 500-mg penicillamine: effect of antacids on absorption. Biopharm Drug Dispos 7:401\u2013405","journal-title":"Biopharm Drug Dispos"},{"key":"5401_CR173","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/1475-2840-12-28","volume":"12","author":"J Lu","year":"2013","unstructured":"Lu J, Pontr\u00e9 B, Pickup S, Choong SY, Li M, Xu H, Gamble GD, Phillips AR, Cowan BR, Young AA, Cooper GJ (2013) Treatment with a copper-selective chelator causes substantive improvement in cardiac function of diabetic rats with left-ventricular impairment. Cardiovasc Diabetol 12:28\u201341","journal-title":"Cardiovasc Diabetol"},{"key":"5401_CR174","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2021-001803","volume":"9","author":"A Reid","year":"2022","unstructured":"Reid A, Miller C, Farrant JP, Polturi R, Clark D, Ray S, Cooper G, Schmitt M (2022) Copper chelation in patients with hypertrophic cardiomyopathy. Open Heart 9:e001803","journal-title":"Open Heart"},{"key":"5401_CR175","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1136\/heartjnl-2022-322271","volume":"109","author":"J Farrant","year":"2023","unstructured":"Farrant J, Dodd S, Vaughan C, Reid A, Schmitt M, Garratt C, Akhtar M, Mahmod M, Neubauer S, Cooper RM, Prasad SK, Singh A, Valkovi\u010d L, Raman B, Ashkir Z, Clayton D, Baroja O, Duran B, Spowart C, Bedson E, Naish JH, Harrington C, Miller CA (2023) Rationale and design of a randomised trial of trientine in patients with hypertrophic cardiomyopathy. Heart 109:1175\u20131182","journal-title":"Heart"},{"key":"5401_CR176","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.cardfail.2023.10.472","volume":"30","author":"JB James Januzzi","year":"2024","unstructured":"James Januzzi JB, Cleland J, Felker M, Mentz R, Wang Y, Zhang Y, Mou H, Jing Yu, Guo Lu, Li G, Chen X, Zhang J (2024) Effect Of Trientine-hydrochloride In Heart Failure With Lower Left Ventricular Ejection Fraction: The TRACER-HF Trial. J Cardiac Fail 30:314\u2013315","journal-title":"J Cardiac Fail"},{"key":"5401_CR177","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.2169\/internalmedicine.50.5209","volume":"50","author":"M Harada","year":"2011","unstructured":"Harada M, Miyagawa K, Honma Y, Hiura M, Shibata M, Matsuhashi T, Abe S, Harada R, Tabaru A (2011) Excess copper chelating therapy for Wilson disease induces anemia and liver dysfunction. Intern Med 50:1461\u20131464","journal-title":"Intern Med"},{"key":"5401_CR178","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.jtcm.2018.02.006","volume":"38","author":"J Zhang","year":"2018","unstructured":"Zhang J, Li L, Chen H, Yang W (2018) Clinical efficacy and safety of Gandouling plus low-dose D-penicillamine for treatment of Wilson\u2019s disease with neurological symptoms. J Tradit Chin Med 38:89\u201394","journal-title":"J Tradit Chin Med"},{"key":"5401_CR179","doi-asserted-by":"publisher","first-page":"2703","DOI":"10.3390\/ani12192703","volume":"12","author":"S Fang","year":"2022","unstructured":"Fang S, Yang W, Zhang K, Peng C (2022) Gandouling mitigates CuSO4-induced heart injury in rats. Animals (Basel) 12:2703\u20132712","journal-title":"Animals (Basel)"},{"key":"5401_CR180","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2022.972198","volume":"10","author":"VJ Lee","year":"2022","unstructured":"Lee VJ, Heffern MC (2022) Structure-activity assessment of flavonoids as modulators of copper transport. Front Chem 10:972198","journal-title":"Front Chem"},{"key":"5401_CR181","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1139\/cjpp-2016-0653","volume":"95","author":"M Zamanian","year":"2017","unstructured":"Zamanian M, Shamsizadeh A, Esmaeili Nadimi A, Hajizadeh M, Allahtavakoli F, Rahmani M, Kaeidi A, Safari Khalegh H, Allahtavakoli M (2017) Short-term effects of troxerutin (vitamin P4) on muscle fatigue and gene expression of Bcl-2 and Bax in the hepatic tissue of rats. Can J Physiol Pharmacol 95:708\u2013713","journal-title":"Can J Physiol Pharmacol"},{"key":"5401_CR182","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.pharmthera.2013.03.009","volume":"139","author":"GV Halade","year":"2013","unstructured":"Halade GV, Jin YF, Lindsey ML (2013) Matrix metalloproteinase (MMP)-9: a proximal biomarker for cardiac remodeling and a distal biomarker for inflammation. Pharmacol Ther 139:32\u201340","journal-title":"Pharmacol Ther"},{"key":"5401_CR183","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1080\/13880209.2016.1244553","volume":"55","author":"M Zamanian","year":"2017","unstructured":"Zamanian M, Hajizadeh M, Shamsizadeh A, Moemenzadeh M, Amirteimouri M, Elshiekh M, Allahtavakoli M (2017) Effects of naringin on physical fatigue and serum MMP-9 concentration in female rats. Pharm Biol 55:423\u2013427","journal-title":"Pharm Biol"},{"key":"5401_CR184","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1016\/j.amjhyper.2005.05.021","volume":"18","author":"N Reshef","year":"2005","unstructured":"Reshef N, Hayari Y, Goren C, Boaz M, Madar Z, Knobler H (2005) Antihypertensive effect of sweetie fruit in patients with stage I hypertension. Am J Hypertens 18:1360\u20131363","journal-title":"Am J Hypertens"},{"key":"5401_CR185","doi-asserted-by":"publisher","first-page":"684","DOI":"10.5414\/CP204058","volume":"59","author":"H Chung","year":"2021","unstructured":"Chung H, Yoon SH, Cho JY, Yeo HK, Shin D, Park JY (2021) Comparative pharmacokinetics of Theracurmin, a highly bioavailable curcumin, in healthy adult subjects. Int J Clin Pharmacol Ther 59:684\u2013690","journal-title":"Int J Clin Pharmacol Ther"},{"key":"5401_CR186","first-page":"201","volume":"40","author":"I Alwi","year":"2008","unstructured":"Alwi I, Santoso T, Suyono S, Sutrisna B, Suyatna FD, Kresno SB, Ernie S (2008) The effect of curcumin on lipid level in patients with acute coronary syndrome. Acta Med Indones 40:201\u2013210","journal-title":"Acta Med Indones"},{"key":"5401_CR187","doi-asserted-by":"publisher","first-page":"28358","DOI":"10.1038\/s41598-025-09783-5","volume":"15","author":"OM El-Rakabawy","year":"2025","unstructured":"El-Rakabawy OM, Elkholy AA, Mahfouz AA, Abdelsalam MM, El Wakeel LM (2025) Curcumin supplementation improves the clinical outcomes of patients with diabetes and atherosclerotic cardiovascular risk. Sci Rep 15:28358","journal-title":"Sci Rep"},{"key":"5401_CR188","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/978-3-030-73234-9_13","volume":"1328","author":"S Tabaee","year":"2021","unstructured":"Tabaee S, Sahebkar A, Aghamohammadi T, Pakdel M, Dehabeh M, Sobhani R, Alidadi M, Majeed M, Mirhafez SR (2021) The effects of curcumin plus piperine supplementation in patients with acute myocardial infarction: a randomized, double-blind, and placebo-controlled trial. Adv Exp Med Biol 1328:199\u2013211","journal-title":"Adv Exp Med Biol"},{"key":"5401_CR189","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3390\/nu8030167","volume":"8","author":"Y Li","year":"2016","unstructured":"Li Y, Yao J, Han C, Yang J, Chaudhry MT, Wang S, Liu H, Yin Y (2016) Quercetin, inflammation and immunity. Nutrients 8:167","journal-title":"Nutrients"},{"key":"5401_CR190","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.nut.2012.01.019","volume":"29","author":"S Bhaskar","year":"2013","unstructured":"Bhaskar S, Kumar KS, Krishnan K, Antony H (2013) Quercetin alleviates hypercholesterolemic diet induced inflammation during progression and regression of atherosclerosis in rabbits. Nutrition 29:219\u2013229","journal-title":"Nutrition"},{"key":"5401_CR191","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.numecd.2011.08.010","volume":"23","author":"M Pfeuffer","year":"2013","unstructured":"Pfeuffer M, Auinger A, Bley U, Kraus-Stojanowic I, Laue C, Winkler P, R\u00fcfer CE, Frank J, B\u00f6sch-Saadatmandi C, Rimbach G, Schrezenmeir J (2013) Effect of quercetin on traits of the metabolic syndrome, endothelial function and inflammation in men with different APOE isoforms. Nutr Metab Cardiovasc Dis 23:403\u2013409","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"5401_CR192","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1017\/S0007114515002950","volume":"114","author":"V Br\u00fcll","year":"2015","unstructured":"Br\u00fcll V, Burak C, Stoffel-Wagner B, Wolffram S, Nickenig G, M\u00fcller C, Langguth P, Alteheld B, Fimmers R, Naaf S, Zimmermann BF, Stehle P, Egert S (2015) Effects of a quercetin-rich onion skin extract on 24 h ambulatory blood pressure and endothelial function in overweight-to-obese patients with (pre-)hypertension: a randomised double-blinded placebo-controlled cross-over trial. Br J Nutr 114:1263\u20131277","journal-title":"Br J Nutr"},{"key":"5401_CR193","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.hjc.2023.08.004","volume":"76","author":"S Kozhukhov","year":"2024","unstructured":"Kozhukhov S, Parkhomenko A, Lutay Y, Dovganych N (2024) Impact of quercetin in patients with myocardial infarction. A multicenter, randomized, and open-label pilot study. Hellenic J Cardiol 76:68\u201374","journal-title":"Hellenic J Cardiol"},{"key":"5401_CR194","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1080\/13543776.2016.1203419","volume":"26","author":"L Chakrawarti","year":"2016","unstructured":"Chakrawarti L, Agrawal R, Dang S, Gupta S, Gabrani R (2016) Therapeutic effects of EGCG: a patent review. Expert Opin Ther Pat 26:907\u2013916","journal-title":"Expert Opin Ther Pat"},{"key":"5401_CR195","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.nutres.2015.10.012","volume":"36","author":"N Suzuki-Sugihara","year":"2016","unstructured":"Suzuki-Sugihara N, Kishimoto Y, Saita E, Taguchi C, Kobayashi M, Ichitani M, Ukawa Y, Sagesaka YM, Suzuki E, Kondo K (2016) Green tea catechins prevent low-density lipoprotein oxidation via their accumulation in low-density lipoprotein particles in humans. Nutr Res 36:16\u201323","journal-title":"Nutr Res"},{"key":"5401_CR196","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1177\/1535370220962708","volume":"246","author":"S Chatree","year":"2021","unstructured":"Chatree S, Sitticharoon C, Maikaew P, Pongwattanapakin K, Keadkraichaiwat I, Churintaraphan M, Sripong C, Sririwichitchai R, Tapechum S (2021) Epigallocatechin gallate decreases plasma triglyceride, blood pressure, and serum kisspeptin in obese human subjects. Exp Biol Med (Maywood) 246:163\u2013176","journal-title":"Exp Biol Med (Maywood)"},{"key":"5401_CR197","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1111\/cts.12905","volume":"14","author":"S Misaka","year":"2021","unstructured":"Misaka S, Ono Y, Uchida A, Ono T, Abe O, Ogata H, Sato H, Suzuki M, Onoue S, Shikama Y, Shimomura K (2021) Impact of green tea catechin ingestion on the pharmacokinetics of Lisinopril in healthy volunteers. Clin Transl Sci 14:476\u2013480","journal-title":"Clin Transl Sci"},{"key":"5401_CR198","doi-asserted-by":"publisher","first-page":"14050","DOI":"10.1038\/s41598-023-41275-2","volume":"13","author":"XY Wei","year":"2023","unstructured":"Wei XY, Zeng YF, Guo QH, Liu JJ, Yin N, Liu Y, Zeng WJ (2023) Cardioprotective effect of epigallocatechin gallate in myocardial ischemia\/reperfusion injury and myocardial infarction: a meta-analysis in preclinical animal studies. Sci Rep 13:14050","journal-title":"Sci Rep"},{"key":"5401_CR199","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/724763","volume":"2013","author":"D Guzman-Villanueva","year":"2013","unstructured":"Guzman-Villanueva D, El-Sherbiny IM, Herrera-Ruiz D, Smyth HD (2013) Design and in vitro evaluation of a new nano-microparticulate system for enhanced aqueous-phase solubility of curcumin. BioMed Res Int 2013:724763","journal-title":"BioMed Res Int"},{"key":"5401_CR200","first-page":"9632","volume":"61","author":"RK Gangwar","year":"2013","unstructured":"Gangwar RK, Tomar GB, Dhumale VA, Zinjarde S, Sharma RB, Datar S (2013) Curcumin conjugated silica nanoparticles for improving bioavailability and its anticancer applications. J Agric Food Chem 61:9632\u20139637","journal-title":"J Agric Food Chem"},{"key":"5401_CR201","doi-asserted-by":"publisher","first-page":"379","DOI":"10.3109\/10717544.2013.848246","volume":"21","author":"H Li","year":"2014","unstructured":"Li H, Zhang N, Hao Y, Wang Y, Jia S, Zhang H, Zhang Y, Zhang Z (2014) Formulation of curcumin delivery with functionalized single-walled carbon nanotubes: characteristics and anticancer effects in vitro. Drug Deliv 21:379\u2013387","journal-title":"Drug Deliv"},{"key":"5401_CR202","doi-asserted-by":"publisher","first-page":"131","DOI":"10.3109\/10717544.2010.520353","volume":"18","author":"Y Gao","year":"2011","unstructured":"Gao Y, Li Z, Sun M, Guo C, Yu A, Xi Y, Cui J, Lou H, Zhai G (2011) Preparation and characterization of intravenously injectable curcumin nanosuspension. Drug Deliv 18:131\u2013142","journal-title":"Drug Deliv"},{"key":"5401_CR203","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s12011-019-01979-x","volume":"197","author":"X Ma","year":"2020","unstructured":"Ma X, Jiang S, Yan S, Li M, Wang C, Pan Y, Sun C, Jin L, Yao Y, Li B (2020) Association between copper, zinc, iron, and selenium intakes and TC\/HDL-C ratio in US adults. Biol Trace Elem Res 197:43\u201351","journal-title":"Biol Trace Elem Res"},{"key":"5401_CR204","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s12872-021-01880-3","volume":"21","author":"C Liu","year":"2021","unstructured":"Liu C, Liao Y, Zhu Z, Yang L, Zhang Q, Li L (2021) The association between serum copper concentrations and elevated blood pressure in US children and adolescents: National Health and Nutrition Examination Survey 2011\u20132016. BMC Cardiovasc Disord 21:57","journal-title":"BMC Cardiovasc Disord"},{"key":"5401_CR205","first-page":"155","volume":"258","author":"SW Mehta","year":"1989","unstructured":"Mehta SW, Eikum R (1989) Effect of estrogen on serum and tissue levels of copper and zinc. Adv Exp Med Biol 258:155\u2013162","journal-title":"Adv Exp Med Biol"},{"key":"5401_CR206","first-page":"91","volume":"13","author":"M Di Gioacchino","year":"2000","unstructured":"Di Gioacchino M, Forcucci R, Tiboni GM, Kouri S, Di Gioacchino F, Boscolo P (2000) The influence of menopause and habitual smoking upon serum zinc, serum copper and the cardiovascular and immune parameters of women. Int J Immunopathol Pharmacol 13:91\u201397","journal-title":"Int J Immunopathol Pharmacol"},{"key":"5401_CR207","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1038\/s41392-022-01229-y","volume":"7","author":"L Chen","year":"2022","unstructured":"Chen L, Min J, Wang F (2022) Copper homeostasis and cuproptosis in health and disease. Signal Transduct Target Ther 7:378","journal-title":"Signal Transduct Target Ther"},{"key":"5401_CR208","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2025.107739","volume":"216","author":"B Kong","year":"2025","unstructured":"Kong B, Zheng X, Hu Y, Zhao Y, Hai J, Ti Y, Bu P (2025) Sirtuin3 attenuates pressure overload-induced pathological myocardial remodeling by inhibiting cardiomyocyte cuproptosis. Pharmacol Res 216:107739","journal-title":"Pharmacol Res"},{"key":"5401_CR209","doi-asserted-by":"crossref","unstructured":"Klevay, L.M. (2008) Endothelial dysfunction, isoprostanes, and copper deficiency. Hypertension. 52, e27; author reply e28.","DOI":"10.1161\/HYPERTENSIONAHA.108.115758"},{"key":"5401_CR210","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.70035","volume":"240","author":"I Orlov","year":"2025","unstructured":"Orlov I, Lenglet G, Avondo C, Beattie JH, Kamel S, Korichneva I (2025) Copper impedes calcification of human aortic vascular smooth muscle cells through inhibition of osteogenic transdifferentiation and promotion of extracellular matrix stability. J Cell Physiol 240:e70035","journal-title":"J Cell Physiol"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-025-05401-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-025-05401-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-025-05401-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T11:03:06Z","timestamp":1771066986000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-025-05401-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,10]]},"references-count":210,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["5401"],"URL":"https:\/\/doi.org\/10.1007\/s11010-025-05401-0","relation":{},"ISSN":["1573-4919"],"issn-type":[{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,10]]},"assertion":[{"value":"2 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}