{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T19:45:50Z","timestamp":1787600750879,"version":"build-2736575974"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Changzhou Sci&Tech Program","award":["No.CJ20220086"],"award-info":[{"award-number":["No.CJ20220086"]}]},{"name":"Changzhou Health Commission Science and Technology Foundation","award":["No.QN202116"],"award-info":[{"award-number":["No.QN202116"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"DOI":"10.1007\/s11010-025-05453-2","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T09:13:57Z","timestamp":1766394837000},"page":"1029-1044","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["ALKBH5 promotes gastric cancer angiogenesis by stabilizing LncRNA PVT1 and VEGFA RNAs via m6A demethylation"],"prefix":"10.1007","volume":"481","author":[{"given":"Qian","family":"Geng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjian","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqian","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"5453_CR1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 74:229\u2013263. https:\/\/doi.org\/10.3322\/caac.21834","journal-title":"CA Cancer J Clin"},{"key":"5453_CR2","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s10456-024-09913-z","volume":"27","author":"F Yang","year":"2024","unstructured":"Yang F, Lee G, Fan Y (2024) Navigating tumor angiogenesis: therapeutic perspectives and myeloid cell regulation mechanism. Angiogenesis 27:333. https:\/\/doi.org\/10.1007\/s10456-024-09913-z","journal-title":"Angiogenesis"},{"key":"5453_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2024.189079","volume":"1879","author":"P Shaw","year":"2024","unstructured":"Shaw P, Dwivedi SKD, Bhattacharya R, Mukherjee P, Rao G (2024) VEGF signaling: role in angiogenesis and beyond. Biochim Biophys Acta Rev Cancer 1879:189079. https:\/\/doi.org\/10.1016\/j.bbcan.2024.189079","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"5453_CR4","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1016\/j.cell.2019.01.021","volume":"176","author":"RS Apte","year":"2019","unstructured":"Apte RS, Chen DS, Ferrara N (2019) VEGF in signaling and disease: beyond discovery and development. Cell 176:1248\u20131264. https:\/\/doi.org\/10.1016\/j.cell.2019.01.021","journal-title":"Cell"},{"key":"5453_CR5","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02249-0","volume":"10","author":"C Lee","year":"2025","unstructured":"Lee C, Kim MJ, Kumar A, Lee HW, Yang Y, Kim Y (2025) Vascular endothelial growth factor signaling in health and disease: from molecular mechanisms to therapeutic perspectives. Signal Transduct Target Ther 10:170. https:\/\/doi.org\/10.1038\/s41392-025-02249-0","journal-title":"Signal Transduct Target Ther"},{"key":"5453_CR6","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s00432-024-05714-5","volume":"150","author":"Y Kang","year":"2024","unstructured":"Kang Y, Li H, Liu Y, Li Z (2024) Regulation of VEGF-A expression and VEGF-A-targeted therapy in malignant tumors. J Cancer Res Clin Oncol 150:221. https:\/\/doi.org\/10.1007\/s00432-024-05714-5","journal-title":"J Cancer Res Clin Oncol"},{"key":"5453_CR7","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/s41467-023-44309-5","volume":"15","author":"JX Lin","year":"2024","unstructured":"Lin JX, Tang YH, Zheng HL, Ye K, Cai JC, Cai LS, Lin W, Xie JW, Wang JB, Lu J, Chen QY, Cao LL, Zheng CH, Li P, Huang CM (2024) Neoadjuvant camrelizumab and apatinib combined with chemotherapy versus chemotherapy alone for locally advanced gastric cancer: a multicenter randomized phase 2 trial. Nat Commun 15:41. https:\/\/doi.org\/10.1038\/s41467-023-44309-5","journal-title":"Nat Commun"},{"key":"5453_CR8","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2024-009983","volume":"12","author":"G Deng","year":"2024","unstructured":"Deng G, Wang P, Su R, Sun X, Wu Z, Huang Z, Gu L, Yu H, Zhao Z, He Y, Huo M, Zhang C, Yin S (2024) SPI1\u2009+\u2009CD68\u2009+\u2009macrophages as a biomarker for gastric cancer metastasis: a rationale for combined antiangiogenic and immunotherapy strategies. J Immunother Cancer 12:e009983. https:\/\/doi.org\/10.1136\/jitc-2024-009983","journal-title":"J Immunother Cancer"},{"key":"5453_CR9","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1186\/s12943-024-02092-x","volume":"23","author":"S Cousin","year":"2024","unstructured":"Cousin S, Gu\u00e9gan JP, Shitara K, Palmieri LJ, Metges JP, Pernot S, Fukuoka S, Koyama S, Nishikawa H, Bellera CA, Adenis A, Gomez-Roca CA, Cassier PA, Hollebecque A, Cantarel C, Kind M, Soubeyran I, Vanhersecke L, Bessede A, Italiano A (2024) Identification of microenvironment features associated with primary resistance to anti-PD-1\/PD-L1\u2009+\u2009antiangiogenesis in gastric cancer through spatial transcriptomics and plasma proteomics. Mol Cancer 23:197. https:\/\/doi.org\/10.1186\/s12943-024-02092-x","journal-title":"Mol Cancer"},{"key":"5453_CR10","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1186\/s12943-024-02089-6","volume":"23","author":"D Chen","year":"2024","unstructured":"Chen D, Gu X, Nurzat Y, Xu L, Li X, Wu L, Jiao H, Gao P, Zhu X, Yan D, Li S, Xue C (2024) Writers, readers, and erasers RNA modifications and drug resistance in cancer. Mol Cancer 23:178. https:\/\/doi.org\/10.1186\/s12943-024-02089-6","journal-title":"Mol Cancer"},{"key":"5453_CR11","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.715","volume":"5","author":"Y Qu","year":"2024","unstructured":"Qu Y, Gao N, Zhang S, Gao L, He B, Wang C, Gong C, Shi Q, Li Z, Yang S, Xiao Y (2024) Role of N6-methyladenosine RNA modification in cancer. MedComm 5:e715. https:\/\/doi.org\/10.1002\/mco2.715","journal-title":"MedComm"},{"key":"5453_CR12","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.tips.2023.11.002","volume":"45","author":"J Cerneckis","year":"2024","unstructured":"Cerneckis J, Ming GL, Song H, He C, Shi Y (2024) The rise of epitranscriptomics: recent developments and future directions. Trends Pharmacol Sci 45:24\u201338. https:\/\/doi.org\/10.1016\/j.tips.2023.11.002","journal-title":"Trends Pharmacol Sci"},{"key":"5453_CR13","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1016\/j.ymthe.2024.05.035","volume":"32","author":"Y Cun","year":"2024","unstructured":"Cun Y, Guo W, Ma B, Okuno Y, Wang J (2024) Decoding the specificity of m6A RNA methylation and its implication in cancer therapy. Mol Ther 32:2461\u20132469. https:\/\/doi.org\/10.1016\/j.ymthe.2024.05.035","journal-title":"Mol Ther"},{"key":"5453_CR14","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s13045-022-01224-4","volume":"15","author":"J Qu","year":"2022","unstructured":"Qu J, Yan H, Hou Y, Cao W, Liu Y, Zhang E, He J, Cai Z (2022) RNA demethylase ALKBH5 in cancer: from mechanisms to therapeutic potential. J Hematol Oncol 15:8. https:\/\/doi.org\/10.1186\/s13045-022-01224-4","journal-title":"J Hematol Oncol"},{"key":"5453_CR15","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1053\/j.gastro.2023.04.032","volume":"165","author":"J Zhai","year":"2023","unstructured":"Zhai J, Chen H, Wong CC, Peng Y, Gou H, Zhang J, Pan Y, Chen D, Lin Y, Wang S, Kang W, To KF, Chen Z, Nie Y, He HH, Sung JJ, Yu J (2023) ALKBH5 drives immune suppression via targeting AXIN2 to promote colorectal cancer and is a target for boosting immunotherapy. Gastroenterology 165:445\u2013462. https:\/\/doi.org\/10.1053\/j.gastro.2023.04.032","journal-title":"Gastroenterology"},{"key":"5453_CR16","doi-asserted-by":"publisher","first-page":"833","DOI":"10.7150\/thno.77441","volume":"13","author":"R Sun","year":"2023","unstructured":"Sun R, Yuan L, Jiang Y, Wan Y, Ma X, Yang J, Sun G, Zhou S, Wang H, Qiu J, Zhang L, Cheng W (2023) ALKBH5 activates FAK signaling through m6A demethylation in ITGB1 mRNA and enhances tumor-associated lymphangiogenesis and lymph node metastasis in ovarian cancer. Theranostics 13:833\u2013848. https:\/\/doi.org\/10.7150\/thno.77441","journal-title":"Theranostics"},{"key":"5453_CR17","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1038\/s41598-024-51994-9","volume":"14","author":"Y Fan","year":"2024","unstructured":"Fan Y, Yan D, Ma L, Liu X, Luo G, Hu Y, Kou X (2024) ALKBH5 is a prognostic factor and promotes the angiogenesis of glioblastoma. Sci Rep 14:1303. https:\/\/doi.org\/10.1038\/s41598-024-51994-9","journal-title":"Sci Rep"},{"key":"5453_CR18","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.yjmcc.2024.05.013","volume":"194","author":"N Gu","year":"2024","unstructured":"Gu N, Shen Y, He Y, Li C, Xiong W, Hu Y, Qiu Z, Peng F, Han W, Li C, Long X, Zhao R, Zhao Y, Shi B (2024) Loss of m6A demethylase ALKBH5 alleviates hypoxia-induced pulmonary arterial hypertension via inhibiting Cyp1a1 mRNA decay. J Mol Cell Cardiol 194:16\u201331. https:\/\/doi.org\/10.1016\/j.yjmcc.2024.05.013","journal-title":"J Mol Cell Cardiol"},{"key":"5453_CR19","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s12935-022-02770-0","volume":"194","author":"W Shen","year":"2022","unstructured":"Shen W, Pu J, Zuo Z, Gu S, Sun J, Tan B, Wang L, Cheng J, Zuo Y (2022) The RNA demethylase ALKBH5 promotes the progression and angiogenesis of lung cancer by regulating the stability of the LncRNA PVT1. J Mol Cell Cardiol 194:16\u201331. https:\/\/doi.org\/10.1186\/s12935-022-02770-0","journal-title":"J Mol Cell Cardiol"},{"key":"5453_CR20","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s11658-022-00385-x","volume":"27","author":"R Li","year":"2022","unstructured":"Li R, Wang X, Zhu C, Wang K (2022) LncRNA PVT1: a novel oncogene in multiple cancers. Cell Mol Biol Lett 27:84. https:\/\/doi.org\/10.1186\/s11658-022-00385-x","journal-title":"Cell Mol Biol Lett"},{"key":"5453_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2023.155019","volume":"253","author":"MA Hakami","year":"2024","unstructured":"Hakami MA, Hazazi A, Khan FR, Abdulaziz O, Alshaghdali K, Abalkhail A, Nassar SA, Omar BIA, Almarshadi F, Gupta G, Binshaya AS (2024) PVT1 lncRNA in lung cancer: a key player in tumorigenesis and therapeutic opportunities. Pathol Res Pract 253:155019. https:\/\/doi.org\/10.1016\/j.prp.2023.155019","journal-title":"Pathol Res Pract"},{"key":"5453_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2025.103722","volume":"85","author":"J Ma","year":"2025","unstructured":"Ma J, Zhang Y, Sun Z, Guo H, Li X, Cai J, Zhang M, Chen M, Jiang J, Zhang L (2025) LncRNA PVT1 promotes cuproptosis through transcriptional activation of FDX1 in colorectal cancer. Redox Biol 85:103722. https:\/\/doi.org\/10.1016\/j.redox.2025.103722","journal-title":"Redox Biol"},{"key":"5453_CR23","doi-asserted-by":"publisher","first-page":"4135","DOI":"10.1111\/cas.15581","volume":"113","author":"D Fang","year":"2022","unstructured":"Fang D, Ou X, Sun K, Zhou X, Li Y, Shi P, Zhao Z, He Y, Peng J, Xu J (2022) m6A modification-mediated LncRNA TP53TG1 inhibits gastric cancer progression by regulating CIP2A stability. Cancer Sci 113:4135\u20134150. https:\/\/doi.org\/10.1111\/cas.15581","journal-title":"Cancer Sci"},{"key":"5453_CR24","doi-asserted-by":"publisher","first-page":"5493","DOI":"10.1007\/s13277-015-4372-4","volume":"37","author":"X Wu","year":"2016","unstructured":"Wu X, Yang T, Liu X, Guo JN, Xie T, Ding Y, Lin M, Yang H (2016) IL-17 promotes tumor angiogenesis through Stat3 pathway mediated upregulation of VEGF in gastric cancer. Tumour Biol 37:5493\u20135501. https:\/\/doi.org\/10.1007\/s13277-015-4372-4","journal-title":"Tumour Biol"},{"key":"5453_CR25","doi-asserted-by":"publisher","first-page":"3207","DOI":"10.1158\/0008-5472.CAN-23-4062","volume":"84","author":"S Liu","year":"2024","unstructured":"Liu S, Lin C, Lin X, Lin P, He R, Pan X, Lin Y, Ye J, Zhu G (2024) NAT10 phase separation regulates YTHDF1 splicing to promote gastric cancer progression. Cancer Res 84:3207\u20133222. https:\/\/doi.org\/10.1158\/0008-5472.CAN-23-4062","journal-title":"Cancer Res"},{"key":"5453_CR26","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1002\/cac2.12534","volume":"44","author":"J Wang","year":"2024","unstructured":"Wang J, Zhang J, Liu H, Meng L, Gao X, Zhao Y, Wang C, Gao X, Fan A, Cao T, Fan D, Zhao X, Lu Y (2024) N6-methyladenosine reader hnRNPA2B1 recognizes and stabilizes NEAT1 to confer chemoresistance in gastric cancer. Cancer Commun 44:469\u2013490. https:\/\/doi.org\/10.1002\/cac2.12534","journal-title":"Cancer Commun"},{"key":"5453_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.169752","volume":"913","author":"T Liu","year":"2024","unstructured":"Liu T, Feng YL, Wang RY, Yang S, Ge YL, Zhang TY, Li J, Li CY, Ruan Y, Luo B, Liang GY (2024) Long-term MNNG exposure promotes gastric carcinogenesis by activating METTL3\/m6A\/miR1184 axis-mediated epithelial-mesenchymal transition. Sci Total Environ 913:169752. https:\/\/doi.org\/10.1016\/j.scitotenv.2023.169752","journal-title":"Sci Total Environ"},{"key":"5453_CR28","doi-asserted-by":"publisher","first-page":"2338","DOI":"10.1038\/s41388-024-03085-2","volume":"43","author":"Y Zang","year":"2024","unstructured":"Zang Y, Tian Z, Wang D, Li Y, Zhang W, Ma C, Liao Z, Gao W, Qian L, Xu X, Jia J, Liu Z (2024) METTL3-mediated N6-methyladenosine modification of STAT5A promotes gastric cancer progression by regulating KLF4. Oncogene 43:2338\u20132354. https:\/\/doi.org\/10.1038\/s41388-024-03085-2","journal-title":"Oncogene"},{"key":"5453_CR29","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202309712","volume":"11","author":"Y Yu","year":"2024","unstructured":"Yu Y, Yang YL, Chen XY, Chen ZY, Zhu JS, Zhang J (2024) Helicobacter pylori-enhanced hnRNPA2B1 coordinates with PABPC1 to promote non-m6A translation and gastric cancer progression. Adv Sci 11:e2309712. https:\/\/doi.org\/10.1002\/advs.202309712","journal-title":"Adv Sci"},{"key":"5453_CR30","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202410806","volume":"12","author":"D Jang","year":"2025","unstructured":"Jang D, Hwa C, Kim S, Oh J, Shin S, Lee SJ, Kim J, Lee SE, Yang Y, Kim D, Lee S, Jung HR, Oh Y, Kim K, Lee HS, An JY, Cho SY (2025) RNA N6-methyladenosine-binding protein YTHDFs redundantly attenuate cancer immunity by downregulating IFN-\u03b3 signaling in gastric cancer. Adv Sci 12:e2410806. https:\/\/doi.org\/10.1002\/advs.202410806","journal-title":"Adv Sci"},{"key":"5453_CR31","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202307242","volume":"11","author":"J Wen","year":"2024","unstructured":"Wen J, Xue L, Wei Y, Liang J, Jia W, Yong T, Chu L, Li H, Han S, Liao J, Chen Z, Liu Y, Liu Q, Ding Z, Liang H, Gan L, Chen X, Huang Z, Zhang B (2024) YTHDF2 is a therapeutic target for HCC by suppressing immune evasion and angiogenesis through ETV5\/PD-L1\/VEGFA axis. Adv Sci 11:e2307242. https:\/\/doi.org\/10.1002\/advs.202307242","journal-title":"Adv Sci"},{"key":"5453_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.216911","volume":"592","author":"Q Liao","year":"2024","unstructured":"Liao Q, Shi H, Yang J, Ge S, Jia R, Song X, Chai P, Jia R (2024) FTO elicits tumor neovascularization in cancer-associated fibroblasts through eliminating m6A modifications of multiple pro-angiogenic factors. Cancer Lett 592:216911. https:\/\/doi.org\/10.1016\/j.canlet.2024.216911","journal-title":"Cancer Lett"},{"key":"5453_CR33","doi-asserted-by":"publisher","first-page":"2548","DOI":"10.1038\/s41388-024-03099-w","volume":"43","author":"P Ding","year":"2024","unstructured":"Ding P, Wu H, Wu J, Li T, He J, Ju Y, Liu Y, Li F, Deng H, Gu R, Zhang L, Guo H, Tian Y, Yang P, Meng N, Li X, Guo Z, Meng L, Zhao Q (2024) N6-methyladenosine modified circPAK2 promotes lymph node metastasis via targeting IGF2BPs\/VEGFA signaling in gastric cancer. Oncogene 43:2548\u20132563. https:\/\/doi.org\/10.1038\/s41388-024-03099-w","journal-title":"Oncogene"},{"key":"5453_CR34","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1038\/s44321-024-00025-1","volume":"16","author":"X Chen","year":"2024","unstructured":"Chen X, Wang Y, Wang JN, Zhang YC, Zhang YR, Sun RX, Qin B, Dai YX, Zhu HJ, Zhao JX, Zhang WW, Ji JD, Yuan ST, Shen QD, Liu QH (2024) Lactylation-driven FTO targets CDK2 to aggravate microvascular anomalies in diabetic retinopathy. EMBO Mol Med 16:294\u2013318. https:\/\/doi.org\/10.1038\/s44321-024-00025-1","journal-title":"EMBO Mol Med"},{"key":"5453_CR35","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1186\/s12974-024-03279-1","volume":"21","author":"Q Zhou","year":"2024","unstructured":"Zhou Q, Liu X, Lu H, Li N, Meng J, Huang J, Zhang Z, Liu J, Fan W, Li W, Li X, Liu X, Zuo H, Yang P, Hou S (2024) m6A-methylase METTL3 promotes retinal angiogenesis through modulation of metabolic reprogramming in RPE cells. J Neuroinflammation 21:289. https:\/\/doi.org\/10.1186\/s12974-024-03279-1","journal-title":"J Neuroinflammation"},{"key":"5453_CR36","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s12943-023-01791-1","volume":"22","author":"H Fang","year":"2023","unstructured":"Fang H, Sun Q, Zhou J, Zhang H, Song Q, Zhang H, Yu G, Guo Y, Huang C, Mou Y, Jia C, Song Y, Liu A, Song K, Lu C, Tian R, Wei S, Yang D, Chen Y, Li T, Wang K, Yu Y, Lv Y, Mo K, Sun P, Yu X, Song X (2023) m6A methylation reader IGF2BP2 activates endothelial cells to promote angiogenesis and metastasis of lung adenocarcinoma. Mol Cancer 22:99. https:\/\/doi.org\/10.1186\/s12943-023-01791-1","journal-title":"Mol Cancer"},{"key":"5453_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.134690","volume":"473","author":"Q Wang","year":"2024","unstructured":"Wang Q, Huang Y, Jiang M, Tang Y, Wang Q, Bai L, Yu C, Yang X, Ding K, Wang W, Bai J, Chen Y (2024) The demethylase ALKBH5 mediates ZKSCAN3 expression through the m6A modification to activate VEGFA transcription and thus participates in MNNG-induced gastric cancer progression. J Hazard Mater 473:34690. https:\/\/doi.org\/10.1016\/j.jhazmat.2024.134690","journal-title":"J Hazard Mater"},{"key":"5453_CR38","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1186\/s13046-024-03029-4","volume":"43","author":"D Suo","year":"2024","unstructured":"Suo D, Gao X, Chen Q, Zeng T, Zhan J, Li G, Zheng Y, Zhu S, Yun J, Guan XY, Li Y (2024) HSPA4 upregulation induces immune evasion via ALKBH5\/CD58 axis in gastric cancer. J Exp Clin Cancer Res 43:106. https:\/\/doi.org\/10.1186\/s13046-024-03029-4","journal-title":"J Exp Clin Cancer Res"},{"key":"5453_CR39","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1016\/j.cell.2018.03.068","volume":"173","author":"SW Cho","year":"2018","unstructured":"Cho SW, Xu J, Sun R, Mumbach MR, Carter AC, Chen YG, Yost KE, Kim J, He J, Nevins SA, Chin SF, Caldas C, Liu SJ, Horlbeck MA, Lim DA, Weissman JS, Curtis C, Chang HY (2018) Promoter of lncRNA gene PVT1 is a tumor-suppressor DNA boundary element. Cell 173:1398-1412e22. https:\/\/doi.org\/10.1016\/j.cell.2018.03.068","journal-title":"Cell"},{"key":"5453_CR40","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49105-3","volume":"15","author":"H Zhang","year":"2024","unstructured":"Zhang H, Sun Y, Wang Z, Huang X, Tang L, Jiang K, Jin X (2024) ZDHHC20-mediated S-palmitoylation of YTHDF3 stabilizes MYC mRNA to promote pancreatic cancer progression. Nat Commun 15:4642. https:\/\/doi.org\/10.1038\/s41467-024-49105-3","journal-title":"Nat Commun"},{"key":"5453_CR41","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.13003","volume":"76","author":"J Duan","year":"2024","unstructured":"Duan J, Fan D, Chen P, Xiang J, Xie X, Peng Y, Bai J, Li T, Li Y, Song H, Fu W, Zhang T, Xiao Y, Qi X, Hong W, Zhou J, He Y, Wu C, Zeng H, Bai H, Chen T, Yu W, Zhang Q (2024) YTHDF3 regulates the degradation and stability of m6A-enriched transcripts to facilitate the progression of castration-resistant prostate cancer. J Pineal Res 76:e13003. https:\/\/doi.org\/10.1111\/jpi.13003","journal-title":"J Pineal Res"},{"key":"5453_CR42","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1205","volume":"13","author":"Y Fang","year":"2023","unstructured":"Fang Y, Wu X, Gu Y, Shi R, Yu T, Pan Y, Zhang J, Jing X, Ma P, Shu Y (2023) LINC00659 cooperated with ALKBH5 to accelerate gastric cancer progression by stabilising JAK1 mRNA in an m6A-YTHDF2\u2010dependent manner. Clin Transl Med 13:e1205. https:\/\/doi.org\/10.1002\/ctm2.1205","journal-title":"Clin Transl Med"},{"key":"5453_CR43","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s12943-022-01522-y","volume":"21","author":"Y Hu","year":"2022","unstructured":"Hu Y, Gong C, Li Z, Liu J, Chen Y, Huang Y, Luo Q, Wang S, Hou Y, Yang S, Xiao Y (2022) Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification. Mol Cancer 21:34. https:\/\/doi.org\/10.1186\/s12943-022-01522-y","journal-title":"Mol Cancer"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-025-05453-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-025-05453-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-025-05453-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T09:22:24Z","timestamp":1772702544000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-025-05453-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,22]]},"references-count":43,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["5453"],"URL":"https:\/\/doi.org\/10.1007\/s11010-025-05453-2","relation":{},"ISSN":["1573-4919"],"issn-type":[{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,22]]},"assertion":[{"value":"23 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest\u00a0"}},{"value":"The obtain of GC tissue samples and paired adjacent normal tissue samples was approved (Approval number: [2021]KY100-01) by the Ethics Committee of The Second People\u2019s Hospital of Changzhou (Changzhou, China). The animal experiments were approved by the Ethics Committee of Experimental Animal Welfare of Nanjing Medical University (IACUC-1705037).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}