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The Animal Ethics Committee of Fujian Medical University has approved the animal experiments conducted in this study. This study was performed in line with the principles of the Declaration of Helsinki. All experiments were performed in accordance with relevant guidelines and regulations.\u00a0Informed consent was obtained from all individual participants included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and\u00a0consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}