{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:06:15Z","timestamp":1792796775981,"version":"4.5.0"},"reference-count":468,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"DOI":"10.1007\/s11010-026-05542-w","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T12:10:15Z","timestamp":1777291815000},"page":"3215-3249","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The central role of mitochondrial dysfunction in neurodegeneration: implications for therapy"],"prefix":"10.1007","volume":"481","author":[{"given":"Mohamed A.","family":"Raafat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaker","family":"Al-Hasnaawei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayjaa Mohaisen","family":"Mousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malathi","family":"Hanumanthayya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Sahoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Prathiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurjant","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aashna","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"5542_CR1","doi-asserted-by":"crossref","unstructured":"Pathak N, Vimal SK, Tandon I, Agrawal L, Hongyi C, Bhattacharyya S (2021) Neurodegenerative disorders of alzheimer, parkinsonism, amyotrophic lateral sclerosis and multiple sclerosis: an early diagnostic approach for precision treatment. Metab Brain Dis. :1\u201338","DOI":"10.1007\/s11011-021-00800-w"},{"issue":"21","key":"5542_CR2","doi-asserted-by":"publisher","first-page":"11847","DOI":"10.3390\/ijms222111847","volume":"22","author":"A Jurcau","year":"2021","unstructured":"Jurcau A (2021) Insights into the pathogenesis of neurodegenerative diseases: Focus on mitochondrial dysfunction and oxidative stress. Int J Mol Sci 22(21):11847","journal-title":"Int J Mol Sci"},{"key":"5542_CR3","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s12325-019-01148-5","volume":"37","author":"M Rekatsina","year":"2020","unstructured":"Rekatsina M, Paladini A, Piroli A, Zis P, Pergolizzi JV, Varrassi G (2020) Pathophysiology and therapeutic perspectives of oxidative stress and neurodegenerative diseases: a narrative review. Adv therapy 37:113\u2013139","journal-title":"Adv therapy"},{"issue":"7","key":"5542_CR4","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.3390\/ijms18071576","volume":"18","author":"J Szyma\u0144ski","year":"2017","unstructured":"Szyma\u0144ski J, Janikiewicz J, Michalska B, Patalas-Krawczyk P, Perrone M, Zi\u00f3\u0142kowski W et al (2017) Interaction of mitochondria with the endoplasmic reticulum and plasma membrane in calcium homeostasis, lipid trafficking and mitochondrial structure. Int J Mol Sci 18(7):1576","journal-title":"Int J Mol Sci"},{"issue":"5","key":"5542_CR5","doi-asserted-by":"publisher","first-page":"91","DOI":"10.31083\/j.jin2305091","volume":"23","author":"Y Li","year":"2024","unstructured":"Li Y, Li T, Chen T, Li C, Yu W, Xu Y et al (2024) The Role of Microglia with Mitochondrial Dysfunction and Its Therapeutic Prospects in Alzheimer\u2019s Disease. J Integr Neurosci 23(5):91","journal-title":"J Integr Neurosci"},{"issue":"5","key":"5542_CR6","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1111\/jpn.12160","volume":"98","author":"J Lapointe","year":"2014","unstructured":"Lapointe J (2014) Mitochondria as promising targets for nutritional interventions aiming to improve performance and longevity of sows. J Anim Physiol Anim Nutr 98(5):809\u2013821","journal-title":"J Anim Physiol Anim Nutr"},{"issue":"1","key":"5542_CR7","first-page":"2105607","volume":"2019","author":"G Cenini","year":"2019","unstructured":"Cenini G, Lloret A, Cascella R (2019) Oxidative stress in neurodegenerative diseases: from a mitochondrial point of view. Oxidative Med Cell Longev 2019(1):2105607","journal-title":"Oxidative Med Cell Longev"},{"issue":"8","key":"5542_CR8","doi-asserted-by":"publisher","first-page":"647","DOI":"10.3390\/antiox9080647","volume":"9","author":"A Picca","year":"2020","unstructured":"Picca A, Calvani R, Coelho-Junior HJ, Landi F, Bernabei R, Marzetti E (2020) Mitochondrial dysfunction, oxidative stress, and neuroinflammation: Intertwined roads to neurodegeneration. Antioxidants 9(8):647","journal-title":"Antioxidants"},{"key":"5542_CR9","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.expneurol.2018.07.009","volume":"309","author":"MK Jha","year":"2018","unstructured":"Jha MK, Morrison BM (2018) Glia-neuron energy metabolism in health and diseases: new insights into the role of nervous system metabolic transporters. Exp Neurol 309:23\u201331","journal-title":"Exp Neurol"},{"issue":"4","key":"5542_CR10","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1242\/jcs.171017","volume":"130","author":"KH Flippo","year":"2017","unstructured":"Flippo KH, Strack S (2017) Mitochondrial dynamics in neuronal injury, development and plasticity. J Cell Sci 130(4):671\u2013681","journal-title":"J Cell Sci"},{"issue":"1","key":"5542_CR11","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/s41583-021-00535-8","volume":"23","author":"S Li","year":"2022","unstructured":"Li S, Sheng Z-H (2022) Energy matters: presynaptic metabolism and the maintenance of synaptic transmission. Nat Rev Neurosci 23(1):4\u201322","journal-title":"Nat Rev Neurosci"},{"issue":"12","key":"5542_CR12","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.3390\/antiox10121917","volume":"10","author":"Y Zhao","year":"2021","unstructured":"Zhao Y, Liu B, Xu L, Yu S, Fu J, Wang J et al (2021) ROS-induced mtDNA release: the emerging messenger for communication between neurons and innate immune cells during neurodegenerative disorder progression. Antioxidants 10(12):1917","journal-title":"Antioxidants"},{"issue":"4","key":"5542_CR13","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/s40572-022-00371-7","volume":"9","author":"A Reddam","year":"2022","unstructured":"Reddam A, McLarnan S, Kupsco A (2022) Environmental chemical exposures and mitochondrial dysfunction: a review of recent literature. Curr Environ health Rep 9(4):631\u2013649","journal-title":"Curr Environ health Rep"},{"key":"5542_CR14","doi-asserted-by":"publisher","first-page":"177","DOI":"10.3389\/fgene.2017.00177","volume":"8","author":"MP Helley","year":"2017","unstructured":"Helley MP, Pinnell J, Sportelli C, Tieu K (2017) Mitochondria: a common target for genetic mutations and environmental toxicants in Parkinson\u2019s disease. Front Genet 8:177","journal-title":"Front Genet"},{"issue":"1","key":"5542_CR15","first-page":"9757201","volume":"2019","author":"W Fu","year":"2019","unstructured":"Fu W, Liu Y, Yin H (2019) Mitochondrial dynamics: biogenesis, fission, fusion, and mitophagy in the regulation of stem cell behaviors. Stem cells Int 2019(1):9757201","journal-title":"Stem cells Int"},{"issue":"s2","key":"5542_CR16","doi-asserted-by":"publisher","first-page":"S401","DOI":"10.3233\/JAD-2010-100666","volume":"20","author":"RX Santos","year":"2010","unstructured":"Santos RX, Correia SC, Wang X, Perry G, Smith MA, Moreira PI et al (2010) A synergistic dysfunction of mitochondrial fission\/fusion dynamics and mitophagy in Alzheimer\u2019s disease. J Alzheimer\u2019s Disease 20(s2):S401\u2013S12","journal-title":"J Alzheimer\u2019s Disease"},{"key":"5542_CR17","doi-asserted-by":"publisher","first-page":"132931","DOI":"10.1016\/j.neulet.2017.06.050","volume":"710","author":"J van Horssen","year":"2019","unstructured":"van Horssen J, van Schaik P, Witte M (2019) Inflammation and mitochondrial dysfunction: A vicious circle in neurodegenerative disorders? Neurosci Lett 710:132931","journal-title":"Neurosci Lett"},{"key":"5542_CR18","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.mito.2023.09.003","volume":"73","author":"H Verma","year":"2023","unstructured":"Verma H, Gangwar P, Yadav A, Yadav B, Rao R, Kaur S et al (2023) Understanding the neuronal synapse and challenges associated with the mitochondrial dysfunction in mild cognitive impairment and Alzheimer\u2019s disease. Mitochondrion 73:19\u201329","journal-title":"Mitochondrion"},{"issue":"12","key":"5542_CR19","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.1016\/j.drudis.2018.08.001","volume":"23","author":"K Kalani","year":"2018","unstructured":"Kalani K, Yan SF, Yan SS (2018) Mitochondrial permeability transition pore: a potential drug target for neurodegeneration. Drug Discovery Today 23(12):1983\u20131989","journal-title":"Drug Discovery Today"},{"key":"5542_CR20","doi-asserted-by":"crossref","unstructured":"Qi Y, Rajbanshi B, Hao R, Dang Y, Xu C, Lu W et al (2025) The dual role of PGAM5 in inflammation. Exp Mol Med. :1\u201314","DOI":"10.1038\/s12276-025-01391-7"},{"issue":"11","key":"5542_CR21","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.3390\/biom11111669","volume":"11","author":"T Sunanda","year":"2021","unstructured":"Sunanda T, Ray B, Mahalakshmi AM, Bhat A, Rashan L, Rungratanawanich W et al (2021) Mitochondria-endoplasmic reticulum crosstalk in Parkinson\u2019s disease: The role of brain renin angiotensin system components. Biomolecules 11(11):1669","journal-title":"Biomolecules"},{"issue":"12","key":"5542_CR22","doi-asserted-by":"publisher","first-page":"3581","DOI":"10.1016\/j.sjbs.2020.07.030","volume":"27","author":"S Dhanasekaran","year":"2020","unstructured":"Dhanasekaran S, Venugopal D, Al-Dayan N, Ravinayagam V, Mohammed AA (2020) Emerging insights into mitochondria-specific targeting and drug delivering strategies: Recent milestones and therapeutic implications. Saudi J Biol Sci 27(12):3581\u20133592","journal-title":"Saudi J Biol Sci"},{"key":"5542_CR23","doi-asserted-by":"publisher","first-page":"101673","DOI":"10.1016\/j.redox.2020.101673","volume":"36","author":"J Williamson","year":"2020","unstructured":"Williamson J, Hughes CM, Cobley JN, Davison GW (2020) The mitochondria-targeted antioxidant MitoQ, attenuates exercise-induced mitochondrial DNA damage. Redox Biol 36:101673","journal-title":"Redox Biol"},{"issue":"4","key":"5542_CR24","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1111\/febs.13175","volume":"282","author":"JA Villena","year":"2015","unstructured":"Villena JA (2015) New insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyond. FEBS J 282(4):647\u2013672","journal-title":"FEBS J"},{"issue":"12","key":"5542_CR25","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.3390\/antiox13121527","volume":"13","author":"Y Izumi","year":"2024","unstructured":"Izumi Y, Koyama Y (2024) Nrf2-Independent Anti-Inflammatory Effects of Dimethyl Fumarate: Challenges and Prospects in Developing Electrophilic Nrf2 Activators for Neurodegenerative Diseases. Antioxidants 13(12):1527","journal-title":"Antioxidants"},{"key":"5542_CR26","doi-asserted-by":"publisher","first-page":"1264842","DOI":"10.3389\/fphar.2023.1264842","volume":"14","author":"G Bresciani","year":"2023","unstructured":"Bresciani G, Manai F, Davinelli S, Tucci P, Saso L, Amadio M (2023) Novel potential pharmacological applications of dimethyl fumarate\u2014an overview and update. Front Pharmacol 14:1264842","journal-title":"Front Pharmacol"},{"key":"5542_CR27","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1007\/s12551-017-0308-0","volume":"9","author":"SH Suhaili","year":"2017","unstructured":"Suhaili SH, Karimian H, Stellato M, Lee T-H, Aguilar M-I (2017) Mitochondrial outer membrane permeabilization: a focus on the role of mitochondrial membrane structural organization. Biophys Rev 9:443\u2013457","journal-title":"Biophys Rev"},{"issue":"3","key":"5542_CR28","doi-asserted-by":"publisher","first-page":"202","DOI":"10.2174\/1874467212666181127151059","volume":"12","author":"RA Zinovkin","year":"2019","unstructured":"Zinovkin RA, Zamyatnin AA (2019) Mitochondria-targeted drugs. Curr Mol Pharmacol 12(3):202\u2013214","journal-title":"Curr Mol Pharmacol"},{"issue":"9529","key":"5542_CR29","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/S0140-6736(06)68970-8","volume":"368","author":"AH Schapira","year":"2006","unstructured":"Schapira AH (2006) Mitochondrial disease. Lancet 368(9529):70\u201382","journal-title":"Lancet"},{"key":"5542_CR30","doi-asserted-by":"crossref","unstructured":"Bhatti JS, Bhatti GK, Reddy PH (2017) Mitochondrial dysfunction and oxidative stress in metabolic disorders\u2014A step towards mitochondria based therapeutic strategies. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. 1863(5):1066\u20131077","DOI":"10.1016\/j.bbadis.2016.11.010"},{"issue":"6","key":"5542_CR31","doi-asserted-by":"publisher","first-page":"470","DOI":"10.3390\/jpm11060470","volume":"11","author":"AY Spivak","year":"2021","unstructured":"Spivak AY, Nedopekina DA, Gubaidullin RR, Dubinin MV, Belosludtsev KN (2021) Conjugation of natural triterpenic acids with delocalized lipophilic cations: selective targeting cancer cell mitochondria. J personalized Med 11(6):470","journal-title":"J personalized Med"},{"key":"5542_CR32","doi-asserted-by":"crossref","unstructured":"Sousa JS, D\u2019Imprima E, Vonck J (2018) Mitochondrial respiratory chain complexes. Membrane protein complexes: structure and function. :167\u2013227","DOI":"10.1007\/978-981-10-7757-9_7"},{"key":"5542_CR33","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.redox.2015.02.001","volume":"4","author":"RJ Mailloux","year":"2015","unstructured":"Mailloux RJ (2015) Teaching the fundamentals of electron transfer reactions in mitochondria and the production and detection of reactive oxygen species. Redox Biol 4:381\u2013398","journal-title":"Redox Biol"},{"issue":"8","key":"5542_CR34","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.3390\/molecules24081583","volume":"24","author":"A Singh","year":"2019","unstructured":"Singh A, Kukreti R, Saso L, Kukreti S (2019) Oxidative stress: a key modulator in neurodegenerative diseases. Molecules 24(8):1583","journal-title":"Molecules"},{"issue":"24","key":"5542_CR35","doi-asserted-by":"publisher","first-page":"2615","DOI":"10.1101\/gad.229724.113","volume":"27","author":"DJ Pagliarini","year":"2013","unstructured":"Pagliarini DJ, Rutter J (2013) Hallmarks of a new era in mitochondrial biochemistry. Genes Dev 27(24):2615\u20132627","journal-title":"Genes Dev"},{"issue":"1","key":"5542_CR36","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/s41467-019-13668-3","volume":"11","author":"I Mart\u00ednez-Reyes","year":"2020","unstructured":"Mart\u00ednez-Reyes I, Chandel NS (2020) Mitochondrial TCA cycle metabolites control physiology and disease. Nat Commun 11(1):102","journal-title":"Nat Commun"},{"issue":"11","key":"5542_CR37","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/s41580-018-0052-8","volume":"19","author":"C Giorgi","year":"2018","unstructured":"Giorgi C, Marchi S, Pinton P (2018) The machineries, regulation and cellular functions of mitochondrial calcium. Nat Rev Mol Cell Biol 19(11):713\u2013730","journal-title":"Nat Rev Mol Cell Biol"},{"key":"5542_CR38","doi-asserted-by":"crossref","unstructured":"Lill R, Hoffmann B, Molik S, Pierik AJ, Rietzschel N, Stehling O et al (2012) The role of mitochondria in cellular iron\u2013sulfur protein biogenesis and iron metabolism. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 1823(9):1491\u20131508","DOI":"10.1016\/j.bbamcr.2012.05.009"},{"key":"5542_CR39","doi-asserted-by":"crossref","unstructured":"Lill R, Diekert K, Kaut A, Lange H, Pelzer W, Prohl C et al (1999) The essential role of mitochondria in the biogenesis of cellular iron-sulfur proteins","DOI":"10.1515\/BC.1999.147"},{"issue":"5","key":"5542_CR40","doi-asserted-by":"publisher","first-page":"2491","DOI":"10.1021\/acs.chemrev.7b00373","volume":"118","author":"X Huang","year":"2017","unstructured":"Huang X, Groves JT (2017) Oxygen activation and radical transformations in heme proteins and metalloporphyrins. Chem Rev 118(5):2491\u20132553","journal-title":"Chem Rev"},{"key":"5542_CR41","doi-asserted-by":"crossref","unstructured":"Amanullah S, Ghosh C, Dey SG, Dey A (2022) Heme Proteins\u2013Structure and Function. Fundamentals of Porphyrin Chemistry: A 21st Century Approach. ;2:709\u2009\u2013\u200942","DOI":"10.1002\/9781119129301.ch16"},{"key":"5542_CR42","doi-asserted-by":"crossref","unstructured":"Maio N, Rouault TA (2015) Iron\u2013sulfur cluster biogenesis in mammalian cells: new insights into the molecular mechanisms of cluster delivery. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 1853(6):1493\u20131512","DOI":"10.1016\/j.bbamcr.2014.09.009"},{"issue":"4","key":"5542_CR43","doi-asserted-by":"publisher","first-page":"685","DOI":"10.18388\/abp.2006_3296","volume":"53","author":"K Brz\u00f3ska","year":"2006","unstructured":"Brz\u00f3ska K, Meczy\u0144ska S, Kruszewski M (2006) Iron-sulfur cluster proteins: electron transfer and beyond. Acta Biochim Pol 53(4):685\u2013691","journal-title":"Acta Biochim Pol"},{"issue":"8","key":"5542_CR44","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1038\/nchembio807","volume":"2","author":"TA Rouault","year":"2006","unstructured":"Rouault TA (2006) The role of iron regulatory proteins in mammalian iron homeostasis and disease. Nat Chem Biol 2(8):406\u2013414","journal-title":"Nat Chem Biol"},{"issue":"10","key":"5542_CR45","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1097\/00004647-200110000-00001","volume":"21","author":"D Attwell","year":"2001","unstructured":"Attwell D, Laughlin SB (2001) An energy budget for signaling in the grey matter of the brain. J Cereb Blood Flow Metabolism 21(10):1133\u20131145","journal-title":"J Cereb Blood Flow Metabolism"},{"issue":"D1","key":"5542_CR46","doi-asserted-by":"publisher","first-page":"D1541","DOI":"10.1093\/nar\/gkaa1011","volume":"49","author":"S Rath","year":"2021","unstructured":"Rath S, Sharma R, Gupta R, Ast T, Chan C, Durham TJ et al (2021) MitoCarta3. 0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations. Nucleic Acids Res 49(D1):D1541\u2013D7","journal-title":"Nucleic Acids Res"},{"issue":"18","key":"5542_CR47","doi-asserted-by":"publisher","first-page":"3622","DOI":"10.1111\/j.1742-4658.2010.07754.x","volume":"277","author":"NB Pivovarova","year":"2010","unstructured":"Pivovarova NB, Andrews SB (2010) Calcium-dependent mitochondrial function and dysfunction in neurons. FEBS J 277(18):3622\u20133636","journal-title":"FEBS J"},{"issue":"5","key":"5542_CR48","doi-asserted-by":"publisher","first-page":"EMMM202216775","DOI":"10.15252\/emmm.202216775","volume":"15","author":"D Erdinc","year":"2023","unstructured":"Erdinc D, Rodr\u00edguez-Luis A, Fassad MR, Mackenzie S, Watson CM, Valenzuela S et al (2023) Pathological variants in TOP3A cause distinct disorders of mitochondrial and nuclear genome stability. EMBO Mol Med 15(5):EMMM202216775","journal-title":"EMBO Mol Med"},{"key":"5542_CR49","doi-asserted-by":"crossref","unstructured":"Stenton SL, Prokisch H (2020) Genetics of mitochondrial diseases: Identifying mutations to help diagnosis. EBioMedicine. ;56","DOI":"10.1016\/j.ebiom.2020.102784"},{"issue":"2","key":"5542_CR50","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1093\/brain\/awab353","volume":"145","author":"YS Ng","year":"2022","unstructured":"Ng YS, Lax NZ, Blain AP, Erskine D, Baker MR, Polvikoski T et al (2022) Forecasting stroke-like episodes and outcomes in mitochondrial disease. Brain 145(2):542\u2013554","journal-title":"Brain"},{"key":"5542_CR51","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/B978-0-12-821751-1.00015-4","volume":"194","author":"S Rahman","year":"2023","unstructured":"Rahman S (2023) Leigh syndrome. Handb Clin Neurol 194:43\u201363","journal-title":"Handb Clin Neurol"},{"issue":"1","key":"5542_CR52","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/cdd.2015.39","volume":"23","author":"B Oettinghaus","year":"2016","unstructured":"Oettinghaus B, Schulz J, Restelli L, Licci M, Savoia C, Schmidt A et al (2016) Synaptic dysfunction, memory deficits and hippocampal atrophy due to ablation of mitochondrial fission in adult forebrain neurons. Cell Death Differ 23(1):18\u201328","journal-title":"Cell Death Differ"},{"issue":"23","key":"5542_CR53","doi-asserted-by":"publisher","first-page":"5066","DOI":"10.1093\/hmg\/dds350","volume":"21","author":"F Diaz","year":"2012","unstructured":"Diaz F, Garcia S, Padgett KR, Moraes CT (2012) A defect in the mitochondrial complex III, but not complex IV, triggers early ROS-dependent damage in defined brain regions. Hum Mol Genet 21(23):5066\u20135077","journal-title":"Hum Mol Genet"},{"issue":"1","key":"5542_CR54","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/s41467-017-01859-9","volume":"9","author":"O Ignatenko","year":"2018","unstructured":"Ignatenko O, Chilov D, Paetau I, de Miguel E, Jackson CB, Capin G et al (2018) Loss of mtDNA activates astrocytes and leads to spongiotic encephalopathy. Nat Commun 9(1):70","journal-title":"Nat Commun"},{"issue":"20","key":"5542_CR55","doi-asserted-by":"publisher","first-page":"8082","DOI":"10.1523\/JNEUROSCI.21-20-08082.2001","volume":"21","author":"L S\u00f6rensen","year":"2001","unstructured":"S\u00f6rensen L, Ekstrand M, Silva J, Lindqvist E, Xu B, Rustin P et al (2001) Late-onset corticohippocampal neurodepletion attributable to catastrophic failure of oxidative phosphorylation in MILON mice. J Neurosci 21(20):8082\u20138090","journal-title":"J Neurosci"},{"key":"5542_CR56","doi-asserted-by":"publisher","first-page":"e47163","DOI":"10.7554\/eLife.47163","volume":"8","author":"I Bolea","year":"2019","unstructured":"Bolea I, Gella A, Sanz E, Prada-Dacasa P, Menardy F, Bard AM et al (2019) Defined neuronal populations drive fatal phenotype in a mouse model of Leigh syndrome. Elife 8:e47163","journal-title":"Elife"},{"issue":"2","key":"5542_CR57","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1097\/NEN.0b013e318244477d","volume":"71","author":"NZ Lax","year":"2012","unstructured":"Lax NZ, Hepplewhite PD, Reeve AK, Nesbitt V, McFarland R, Jaros E et al (2012) Cerebellar ataxia in patients with mitochondrial DNA disease: a molecular clinicopathological study. J Neuropathology Experimental Neurol 71(2):148\u2013161","journal-title":"J Neuropathology Experimental Neurol"},{"issue":"5","key":"5542_CR58","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1111\/nan.12282","volume":"42","author":"A Chrysostomou","year":"2016","unstructured":"Chrysostomou A, Grady JP, Laude A, Taylor RW, Turnbull DM, Lax NZ (2016) Investigating complex I deficiency in P urkinje cells and synapses in patients with mitochondrial disease. Neuropathol Appl Neurobiol 42(5):477\u2013492","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"7","key":"5542_CR59","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1038\/jcbfm.2012.35","volume":"32","author":"C Howarth","year":"2012","unstructured":"Howarth C, Gleeson P, Attwell D (2012) Updated energy budgets for neural computation in the neocortex and cerebellum. J Cereb Blood Flow Metabolism 32(7):1222\u20131232","journal-title":"J Cereb Blood Flow Metabolism"},{"issue":"5","key":"5542_CR60","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.neuron.2008.05.008","volume":"58","author":"C De Solages","year":"2008","unstructured":"De Solages C, Szapiro G, Brunel N, Hakim V, Isope P, Buisseret P et al (2008) High-frequency organization and synchrony of activity in the purkinje cell layer of the cerebellum. Neuron 58(5):775\u2013788","journal-title":"Neuron"},{"key":"5542_CR61","doi-asserted-by":"crossref","unstructured":"Ekstrand MI, Terzioglu M, Galter D, Zhu S, Hofstetter C, Lindqvist E et al (2007) Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons. Proceedings of the National Academy of Sciences. ;104(4):1325-30","DOI":"10.1073\/pnas.0605208103"},{"issue":"8","key":"5542_CR62","doi-asserted-by":"publisher","first-page":"e71341","DOI":"10.1371\/journal.pone.0071341","volume":"8","author":"X Li","year":"2013","unstructured":"Li X, Redus L, Chen C, Martinez PA, Strong R, Li S et al (2013) Cognitive dysfunction precedes the onset of motor symptoms in the MitoPark mouse model of Parkinson\u2019s disease. PLoS ONE 8(8):e71341","journal-title":"PLoS ONE"},{"key":"5542_CR63","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.nbd.2015.08.005","volume":"90","author":"O Kann","year":"2016","unstructured":"Kann O (2016) The interneuron energy hypothesis: implications for brain disease. Neurobiol Dis 90:75\u201385","journal-title":"Neurobiol Dis"},{"key":"5542_CR64","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.nbd.2016.04.004","volume":"93","author":"M Inan","year":"2016","unstructured":"Inan M, Zhao M, Manuszak M, Karakaya C, Rajadhyaksha AM, Pickel VM et al (2016) Energy deficit in parvalbumin neurons leads to circuit dysfunction, impaired sensory gating and social disability. Neurobiol Dis 93:35\u201346","journal-title":"Neurobiol Dis"},{"issue":"1","key":"5542_CR65","doi-asserted-by":"publisher","first-page":"14329","DOI":"10.1038\/ncomms14329","volume":"8","author":"Y Zhang","year":"2017","unstructured":"Zhang Y, Su SS, Zhao S, Yang Z, Zhong C-Q, Chen X et al (2017) RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome. Nat Commun 8(1):14329","journal-title":"Nat Commun"},{"issue":"2","key":"5542_CR66","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/s41580-019-0173-8","volume":"21","author":"FJ Bock","year":"2020","unstructured":"Bock FJ, Tait SW (2020) Mitochondria as multifaceted regulators of cell death. Nat Rev Mol Cell Biol 21(2):85\u2013100","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"5542_CR67","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1186\/s12974-018-1235-0","volume":"15","author":"YK Dhuriya","year":"2018","unstructured":"Dhuriya YK, Sharma D (2018) Necroptosis: a regulated inflammatory mode of cell death. J Neuroinflamm 15(1):199","journal-title":"J Neuroinflamm"},{"issue":"3","key":"5542_CR68","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1042\/EBC20170104","volume":"62","author":"L Tilokani","year":"2018","unstructured":"Tilokani L, Nagashima S, Paupe V, Prudent J (2018) Mitochondrial dynamics: overview of molecular mechanisms. Essays Biochem 62(3):341\u2013360","journal-title":"Essays Biochem"},{"key":"5542_CR69","doi-asserted-by":"publisher","first-page":"106101","DOI":"10.1016\/j.biocel.2021.106101","volume":"141","author":"IM Hemel","year":"2021","unstructured":"Hemel IM, Sarantidou R, Gerards M (2021) It takes two to tango: The essential role of ER-mitochondrial contact sites in mitochondrial dynamics. Int J Biochem Cell Biol 141:106101","journal-title":"Int J Biochem Cell Biol"},{"issue":"6","key":"5542_CR70","doi-asserted-by":"publisher","first-page":"5785","DOI":"10.3390\/ijms24065785","volume":"24","author":"M Zerihun","year":"2023","unstructured":"Zerihun M, Sukumaran S, Qvit N (2023) The Drp1-mediated mitochondrial fission protein interactome as an emerging core player in mitochondrial dynamics and cardiovascular disease therapy. Int J Mol Sci 24(6):5785","journal-title":"Int J Mol Sci"},{"issue":"1","key":"5542_CR71","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.1038\/s41467-022-29945-7","volume":"13","author":"V Sidarala","year":"2022","unstructured":"Sidarala V, Zhu J, Levi-D\u2019Ancona E, Pearson GL, Reck EC, Walker EM et al (2022) Mitofusin 1 and 2 regulation of mitochondrial DNA content is a critical determinant of glucose homeostasis. Nat Commun 13(1):2340","journal-title":"Nat Commun"},{"issue":"8","key":"5542_CR72","doi-asserted-by":"publisher","first-page":"e99748","DOI":"10.15252\/embj.201899748","volume":"38","author":"R Yu","year":"2019","unstructured":"Yu R, Jin SB, Lendahl U, Nist\u00e9r M, Zhao J (2019) Human Fis1 regulates mitochondrial dynamics through inhibition of the fusion machinery. EMBO J 38(8):e99748","journal-title":"EMBO J"},{"key":"5542_CR73","doi-asserted-by":"publisher","first-page":"660095","DOI":"10.3389\/fendo.2021.660095","volume":"12","author":"UK Ihenacho","year":"2021","unstructured":"Ihenacho UK, Meacham KA, Harwig MC, Widlansky ME, Hill RB (2021) Mitochondrial fission protein 1: emerging roles in organellar form and function in health and disease. Front Endocrinol 12:660095","journal-title":"Front Endocrinol"},{"key":"5542_CR74","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.ceca.2017.05.003","volume":"69","author":"S Marchi","year":"2018","unstructured":"Marchi S, Patergnani S, Missiroli S, Morciano G, Rimessi A, Wieckowski MR et al (2018) Mitochondrial and endoplasmic reticulum calcium homeostasis and cell death. Cell Calcium 69:62\u201372","journal-title":"Cell Calcium"},{"key":"5542_CR75","doi-asserted-by":"publisher","first-page":"111212","DOI":"10.1016\/j.mad.2020.111212","volume":"186","author":"YJ Liu","year":"2020","unstructured":"Liu YJ, McIntyre RL, Janssens GE, Houtkooper RH (2020) Mitochondrial fission and fusion: A dynamic role in aging and potential target for age-related disease. Mech Ageing Dev 186:111212","journal-title":"Mech Ageing Dev"},{"issue":"4","key":"5542_CR76","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1038\/s41418-020-00641-7","volume":"28","author":"J Huang","year":"2021","unstructured":"Huang J, Xie P, Dong Y, An W (2021) Inhibition of Drp1 SUMOylation by ALR protects the liver from ischemia-reperfusion injury. Cell Death Differ 28(4):1174\u20131192","journal-title":"Cell Death Differ"},{"key":"5542_CR77","doi-asserted-by":"crossref","unstructured":"Cohen MM, Tareste D (2018) Recent insights into the structure and function of Mitofusins in mitochondrial fusion. F1000Research. ;7:F1000 Faculty Rev-983.","DOI":"10.12688\/f1000research.16629.1"},{"key":"5542_CR78","doi-asserted-by":"publisher","first-page":"858286","DOI":"10.3389\/fcell.2022.858286","volume":"10","author":"M Zaman","year":"2022","unstructured":"Zaman M, Shutt TE (2022) The role of impaired mitochondrial dynamics in MFN2-mediated pathology. Front cell Dev biology 10:858286","journal-title":"Front cell Dev biology"},{"issue":"9","key":"5542_CR79","doi-asserted-by":"publisher","first-page":"e51954","DOI":"10.15252\/embr.202051954","volume":"22","author":"S Casellas-D\u00edaz","year":"2021","unstructured":"Casellas-D\u00edaz S, Larramona\u2010Arcas R, Riqu\u00e9\u2010Pujol G, Tena\u2010Morraja P, M\u00fcller\u2010S\u00e1nchez C, Segarra\u2010Mondejar M et al (2021) Mfn2 localization in the ER is necessary for its bioenergetic function and neuritic development. EMBO Rep 22(9):e51954","journal-title":"EMBO Rep"},{"key":"5542_CR80","doi-asserted-by":"publisher","first-page":"626117","DOI":"10.3389\/fcell.2021.626117","volume":"9","author":"R Gilkerson","year":"2021","unstructured":"Gilkerson R, De La Torre P, St. Vallier S (2021) Mitochondrial OMA1 and OPA1 as gatekeepers of organellar structure\/function and cellular stress response. Front cell Dev biology 9:626117","journal-title":"Front cell Dev biology"},{"issue":"1","key":"5542_CR81","first-page":"18","volume":"41","author":"S-M Yoo","year":"2018","unstructured":"Yoo S-M, Jung Y-K (2018) A molecular approach to mitophagy and mitochondrial dynamics. Mol Cells 41(1):18\u201326","journal-title":"Mol Cells"},{"issue":"4","key":"5542_CR82","doi-asserted-by":"publisher","first-page":"R170","DOI":"10.1016\/j.cub.2018.01.004","volume":"28","author":"S Pickles","year":"2018","unstructured":"Pickles S, Vigi\u00e9 P, Youle RJ (2018) Mitophagy and quality control mechanisms in mitochondrial maintenance. Curr Biol 28(4):R170\u2013R85","journal-title":"Curr Biol"},{"issue":"1","key":"5542_CR83","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1042\/BJ20140334","volume":"460","author":"A Kazlauskaite","year":"2014","unstructured":"Kazlauskaite A, Kondapalli C, Gourlay R, Campbell DG, Ritorto MS, Hofmann K et al (2014) Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65. Biochem J 460(1):127\u2013141","journal-title":"Biochem J"},{"issue":"2","key":"5542_CR84","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1083\/jcb.201402104","volume":"205","author":"LA Kane","year":"2014","unstructured":"Kane LA, Lazarou M, Fogel AI, Li Y, Yamano K, Sarraf SA et al (2014) PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity. J Cell Biol 205(2):143\u2013153","journal-title":"J Cell Biol"},{"issue":"7565","key":"5542_CR85","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/nature14893","volume":"524","author":"M Lazarou","year":"2015","unstructured":"Lazarou M, Sliter DA, Kane LA, Sarraf SA, Wang C, Burman JL et al (2015) The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy. Nature 524(7565):309\u2013314","journal-title":"Nature"},{"issue":"7","key":"5542_CR86","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1083\/jcb.201007013","volume":"191","author":"A Tanaka","year":"2010","unstructured":"Tanaka A, Cleland MM, Xu S, Narendra DP, Suen D-F, Karbowski M et al (2010) Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin. J Cell Biol 191(7):1367\u20131380","journal-title":"J Cell Biol"},{"issue":"3","key":"5542_CR87","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.molcel.2014.02.034","volume":"54","author":"G Chen","year":"2014","unstructured":"Chen G, Han Z, Feng D, Chen Y, Chen L, Wu H et al (2014) A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy. Mol Cell 54(3):362\u2013377","journal-title":"Mol Cell"},{"issue":"4","key":"5542_CR88","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1080\/15548627.2016.1151580","volume":"12","author":"M Chen","year":"2016","unstructured":"Chen M, Chen Z, Wang Y, Tan Z, Zhu C, Li Y et al (2016) Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy. Autophagy 12(4):689\u2013702","journal-title":"Autophagy"},{"issue":"9","key":"5542_CR89","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1007\/s00018-018-2990-x","volume":"76","author":"PP Praharaj","year":"2019","unstructured":"Praharaj PP, Naik PP, Panigrahi DP, Bhol CS, Mahapatra KK, Patra S et al (2019) Intricate role of mitochondrial lipid in mitophagy and mitochondrial apoptosis: its implication in cancer therapeutics. Cell Mol Life Sci 76(9):1641\u20131652","journal-title":"Cell Mol Life Sci"},{"issue":"9","key":"5542_CR90","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1038\/s41556-018-0176-2","volume":"20","author":"K Palikaras","year":"2018","unstructured":"Palikaras K, Lionaki E, Tavernarakis N (2018) Mechanisms of mitophagy in cellular homeostasis, physiology and pathology. Nat Cell Biol 20(9):1013\u20131022","journal-title":"Nat Cell Biol"},{"key":"5542_CR91","doi-asserted-by":"crossref","unstructured":"Grivennikova VG, Vinogradov AD (2006) Generation of superoxide by the mitochondrial Complex I. Biochimica et Biophysica Acta (BBA)-Bioenergetics. 1757(5\u20136):553\u2013561","DOI":"10.1016\/j.bbabio.2006.03.013"},{"issue":"47","key":"5542_CR92","doi-asserted-by":"publisher","first-page":"49064","DOI":"10.1074\/jbc.M407715200","volume":"279","author":"FL Muller","year":"2004","unstructured":"Muller FL, Liu Y, Van Remmen H (2004) Complex III releases superoxide to both sides of the inner mitochondrial membrane. J Biol Chem 279(47):49064\u201349073","journal-title":"J Biol Chem"},{"issue":"2","key":"5542_CR93","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/ncb2422","volume":"14","author":"L Liu","year":"2012","unstructured":"Liu L, Feng D, Chen G, Chen M, Zheng Q, Song P et al (2012) Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nat Cell Biol 14(2):177\u2013185","journal-title":"Nat Cell Biol"},{"issue":"16","key":"5542_CR94","doi-asserted-by":"publisher","first-page":"9082","DOI":"10.1073\/pnas.97.16.9082","volume":"97","author":"RK Bruick","year":"2000","unstructured":"Bruick RK (2000) Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Proc Natl Acad Sci 97(16):9082\u20139087","journal-title":"Proc Natl Acad Sci"},{"issue":"9","key":"5542_CR95","doi-asserted-by":"publisher","first-page":"2528","DOI":"10.1093\/hmg\/ddv017","volume":"24","author":"F Gao","year":"2015","unstructured":"Gao F, Chen D, Si J, Hu Q, Qin Z, Fang M et al (2015) The mitochondrial protein BNIP3L is the substrate of PARK2 and mediates mitophagy in PINK1\/PARK2 pathway. Hum Mol Genet 24(9):2528\u20132538","journal-title":"Hum Mol Genet"},{"key":"5542_CR96","doi-asserted-by":"crossref","unstructured":"Panigrahi DP, Praharaj PP, Bhol CS, Mahapatra KK, Patra S, Behera BP et al (eds) (2020) The emerging, multifaceted role of mitophagy in cancer and cancer therapeutics. Seminars in cancer biology. Elsevier","DOI":"10.1016\/j.semcancer.2019.07.015"},{"issue":"10","key":"5542_CR97","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1016\/j.freeradbiomed.2010.02.020","volume":"48","author":"G Paradies","year":"2010","unstructured":"Paradies G, Petrosillo G, Paradies V, Ruggiero FM (2010) Oxidative stress, mitochondrial bioenergetics, and cardiolipin in aging. Free Radic Biol Med 48(10):1286\u20131295","journal-title":"Free Radic Biol Med"},{"key":"5542_CR98","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.ceb.2014.09.010","volume":"33","author":"CR Reczek","year":"2015","unstructured":"Reczek CR, Chandel NS (2015) ROS-dependent signal transduction. Curr Opin Cell Biol 33:8\u201313","journal-title":"Curr Opin Cell Biol"},{"issue":"13","key":"5542_CR99","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1089\/ars.2016.6925","volume":"27","author":"X Ren","year":"2017","unstructured":"Ren X, Zou L, Zhang X, Branco V, Wang J, Carvalho C et al (2017) Redox signaling mediated by thioredoxin and glutathione systems in the central nervous system. Antioxid Redox Signal 27(13):989\u20131010","journal-title":"Antioxid Redox Signal"},{"issue":"5","key":"5542_CR100","doi-asserted-by":"publisher","first-page":"749","DOI":"10.4103\/1673-5374.249218","volume":"14","author":"U Shefa","year":"2019","unstructured":"Shefa U, Jeong NY, Song IO, Chung H-J, Kim D, Jung J et al (2019) Mitophagy links oxidative stress conditions and neurodegenerative diseases. Neural Regen Res 14(5):749\u2013756","journal-title":"Neural Regen Res"},{"issue":"10","key":"5542_CR101","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.4161\/auto.21211","volume":"8","author":"Y Wang","year":"2012","unstructured":"Wang Y, Nartiss Y, Steipe B, McQuibban GA, Kim PK (2012) ROS-induced mitochondrial depolarization initiates PARK2\/PARKIN-dependent mitochondrial degradation by autophagy. Autophagy 8(10):1462\u20131476","journal-title":"Autophagy"},{"issue":"10","key":"5542_CR102","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1038\/embor.2012.128","volume":"13","author":"T Shutt","year":"2012","unstructured":"Shutt T, Geoffrion M, Milne R, McBride HM (2012) The intracellular redox state is a core determinant of mitochondrial fusion. EMBO Rep 13(10):909","journal-title":"EMBO Rep"},{"issue":"5675","key":"5542_CR103","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1126\/science.1093891","volume":"304","author":"KK Chung","year":"2004","unstructured":"Chung KK, Thomas B, Li X, Pletnikova O, Troncoso JC, Marsh L et al (2004) S-nitrosylation of parkin regulates ubiquitination and compromises parkin\u2019s protective function. Science 304(5675):1328\u20131331","journal-title":"Science"},{"issue":"8","key":"5542_CR104","doi-asserted-by":"publisher","first-page":"EMMM201910409","DOI":"10.15252\/emmm.201910409","volume":"11","author":"SH Lee","year":"2019","unstructured":"Lee SH, Lee S, Du J, Jain K, Ding M, Kadado AJ et al (2019) Mitochondrial MsrB2 serves as a switch and transducer for mitophagy. EMBO Mol Med 11(8):EMMM201910409","journal-title":"EMBO Mol Med"},{"issue":"15","key":"5542_CR105","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1038\/emboj.2013.125","volume":"32","author":"T Wauer","year":"2013","unstructured":"Wauer T, Komander D (2013) Structure of the human Parkin ligase domain in an autoinhibited state. EMBO J 32(15):2099","journal-title":"EMBO J"},{"key":"5542_CR106","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.freeradbiomed.2015.04.036","volume":"88","author":"AT Dinkova-Kostova","year":"2015","unstructured":"Dinkova-Kostova AT, Abramov AY (2015) The emerging role of Nrf2 in mitochondrial function. Free Radic Biol Med 88:179\u2013188","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"5542_CR107","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.cmet.2018.06.014","volume":"28","author":"T Yamada","year":"2018","unstructured":"Yamada T, Murata D, Adachi Y, Itoh K, Kameoka S, Igarashi A et al (2018) Mitochondrial stasis reveals p62-mediated ubiquitination in parkin-independent mitophagy and mitigates nonalcoholic fatty liver disease. Cell Metabol 28(4):588\u2013604 e5","journal-title":"Cell Metabol"},{"issue":"18","key":"5542_CR108","first-page":"6669","volume":"61","author":"HM Sowter","year":"2001","unstructured":"Sowter HM, Ratcliffe PJ, Watson P, Greenberg AH, Harris AL (2001) HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Cancer Res 61(18):6669\u20136673","journal-title":"Cancer Res"},{"issue":"18","key":"5542_CR109","doi-asserted-by":"publisher","first-page":"2748","DOI":"10.1038\/emboj.2009.210","volume":"28","author":"C Huang","year":"2009","unstructured":"Huang C, Han Y, Wang Y, Sun X, Yan S, Yeh ET et al (2009) SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de\u2010SUMOylation. EMBO J 28(18):2748\u20132762","journal-title":"EMBO J"},{"issue":"9","key":"5542_CR110","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.15252\/embr.201540759","volume":"16","author":"AH Chourasia","year":"2015","unstructured":"Chourasia AH, Tracy K, Frankenberger C, Boland ML, Sharifi MN, Drake LE et al (2015) Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis. EMBO Rep 16(9):1145\u20131163","journal-title":"EMBO Rep"},{"key":"5542_CR111","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.freeradbiomed.2016.04.197","volume":"100","author":"B Osborne","year":"2016","unstructured":"Osborne B, Bentley NL, Montgomery MK, Turner N (2016) The role of mitochondrial sirtuins in health and disease. Free Radic Biol Med 100:164\u2013174","journal-title":"Free Radic Biol Med"},{"key":"5542_CR112","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.freeradbiomed.2013.05.002","volume":"63","author":"AH Tseng","year":"2013","unstructured":"Tseng AH, Shieh S-S, Wang DL (2013) SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage. Free Radic Biol Med 63:222\u2013234","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"5542_CR113","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.tins.2017.01.002","volume":"40","author":"JS Kerr","year":"2017","unstructured":"Kerr JS, Adriaanse BA, Greig NH, Mattson MP, Cader MZ, Bohr VA et al (2017) Mitophagy and Alzheimer\u2019s disease: cellular and molecular mechanisms. Trends Neurosci 40(3):151\u2013166","journal-title":"Trends Neurosci"},{"issue":"3","key":"5542_CR114","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/s41593-018-0332-9","volume":"22","author":"EF Fang","year":"2019","unstructured":"Fang EF, Hou Y, Palikaras K, Adriaanse BA, Kerr JS, Yang B et al (2019) Mitophagy inhibits amyloid-\u03b2 and tau pathology and reverses cognitive deficits in models of Alzheimer\u2019s disease. Nat Neurosci 22(3):401\u2013412","journal-title":"Nat Neurosci"},{"key":"5542_CR115","doi-asserted-by":"publisher","first-page":"617588","DOI":"10.3389\/fnagi.2021.617588","volume":"13","author":"A Misrani","year":"2021","unstructured":"Misrani A, Tabassum S, Yang L (2021) Mitochondrial dysfunction and oxidative stress in Alzheimer\u2019s disease. Front Aging Neurosci 13:617588","journal-title":"Front Aging Neurosci"},{"key":"5542_CR116","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.mito.2023.05.007","volume":"71","author":"T Alqahtani","year":"2023","unstructured":"Alqahtani T, Deore SL, Kide AA, Shende BA, Sharma R, Chakole RD et al (2023) Mitochondrial dysfunction and oxidative stress in Alzheimer\u2019s disease, and Parkinson\u2019s disease, Huntington\u2019s disease and amyotrophic lateral sclerosis-an updated review. Mitochondrion 71:83\u201392","journal-title":"Mitochondrion"},{"issue":"3","key":"5542_CR117","doi-asserted-by":"publisher","first-page":"543","DOI":"10.4103\/1673-5374.320970","volume":"17","author":"Y Ju","year":"2022","unstructured":"Ju Y, Tam KY (2022) Pathological mechanisms and therapeutic strategies for Alzheimer\u2019s disease. Neural Regen Res 17(3):543\u2013549","journal-title":"Neural Regen Res"},{"issue":"5","key":"5542_CR118","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.jalz.2016.09.003","volume":"13","author":"D Mastroeni","year":"2017","unstructured":"Mastroeni D, Khdour OM, Delvaux E, Nolz J, Olsen G, Berchtold N et al (2017) Nuclear but not mitochondrial-encoded oxidative phosphorylation genes are altered in aging, mild cognitive impairment, and Alzheimer\u2019s disease. Alzheimer\u2019s Dement 13(5):510\u2013519","journal-title":"Alzheimer\u2019s Dement"},{"issue":"1\u20134","key":"5542_CR119","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/0169-328X(94)90147-3","volume":"24","author":"K Chandrasekaran","year":"1994","unstructured":"Chandrasekaran K, Giordano T, Brady DR, Stoll J, Martin LJ, Rapoport SI (1994) Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease. Mol Brain Res 24(1\u20134):336\u2013340","journal-title":"Mol Brain Res"},{"issue":"5","key":"5542_CR120","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1097\/00005072-199409000-00010","volume":"53","author":"NA Simonian","year":"1994","unstructured":"Simonian NA, Hyman BT (1994) Functional alterations in Alzheimer\u2019s disease: selective loss of mitochondrial-encoded cytochrome oxidase mRNA in the hippocampal formation. J Neuropathology Experimental Neurol 53(5):508\u2013512","journal-title":"J Neuropathology Experimental Neurol"},{"issue":"2","key":"5542_CR121","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1385\/NMM:5:2:147","volume":"5","author":"M Manczak","year":"2004","unstructured":"Manczak M, Park BS, Jung Y, Reddy PH (2004) Differential expression of oxidative phosphorylation genes in patients with Alzheimer\u2019s disease: implications for early mitochondrial dysfunction and oxidative damage. Neuromol Med 5(2):147\u2013162","journal-title":"Neuromol Med"},{"issue":"1","key":"5542_CR122","doi-asserted-by":"publisher","first-page":"4314025","DOI":"10.1155\/2017\/4314025","volume":"2017","author":"KK Griffiths","year":"2017","unstructured":"Griffiths KK, Levy RJ (2017) Evidence of mitochondrial dysfunction in autism: Biochemical links, genetic-based associations, and non\u2010energy\u2010related mechanisms. Oxidative Med Cell Longev 2017(1):4314025","journal-title":"Oxidative Med Cell Longev"},{"issue":"8","key":"5542_CR123","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1038\/labinvest.3780140","volume":"80","author":"SM de la Monte","year":"2000","unstructured":"de la Monte SM, Luong T, Neely TR, Robinson D, Wands JR (2000) Mitochondrial DNA damage as a mechanism of cell loss in Alzheimer\u2019s disease. Lab Invest 80(8):1323\u20131335","journal-title":"Lab Invest"},{"issue":"5","key":"5542_CR124","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1097\/00001756-199503270-00002","volume":"6","author":"P Chagnon","year":"1995","unstructured":"Chagnon P, B\u00e9tard C, Robitaille Y, Cholette A, Gauvrea D (1995) Distribution of brain cytochrome oxidase activity in various neurodegenerative diseases. NeuroReport 6(5):711\u2013715","journal-title":"NeuroReport"},{"issue":"6","key":"5542_CR125","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1046\/j.1471-4159.1994.63062179.x","volume":"63","author":"EM Mutisya","year":"1994","unstructured":"Mutisya EM, Bowling AC, Beal MF (1994) Cortical cytochrome oxidase activity is reduced in Alzheimer\u2019s disease. J Neurochem 63(6):2179\u20132184","journal-title":"J Neurochem"},{"issue":"6","key":"5542_CR126","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1212\/WNL.44.6.1090","volume":"44","author":"WD Parker Jr","year":"1994","unstructured":"Parker WD Jr, BA JP, Filley CM, Kleinschmidt-DeMasters B (1994) Electron transport chain defects in Alzheimer\u2019s disease brain. Neurology 44(6):1090","journal-title":"Neurology"},{"issue":"3","key":"5542_CR127","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1212\/WNL.45.3.482","volume":"45","author":"WD Parker Jr","year":"1995","unstructured":"Parker WD Jr, Parks JK (1995) Cytochrome c oxidase in Alzheimer\u2019s disease brain: purification and characterization. Neurology 45(3):482\u2013486","journal-title":"Neurology"},{"issue":"24","key":"5542_CR128","doi-asserted-by":"publisher","first-page":"3593","DOI":"10.1016\/S0042-6989(96)00210-6","volume":"37","author":"M Wong-Riley","year":"1997","unstructured":"Wong-Riley M, Antuono P, Ho K-C, Egan R, Hevner R, Liebl W et al (1997) Cytochrome oxidase in Alzheimer\u2019s disease: biochemical, histochemical, and immunohistochemical analyses of the visual and other systems. Vision Res 37(24):3593\u20133608","journal-title":"Vision Res"},{"issue":"1","key":"5542_CR129","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1006\/exnr.1996.0180","volume":"142","author":"K Chandrasekaran","year":"1996","unstructured":"Chandrasekaran K, Hatanp\u00e4\u00e4 K, Brady DR, Rapoport SI (1996) Evidence for physiological down-regulation of brain oxidative phosphorylation in Alzheimer\u2019s disease. Exp Neurol 142(1):80\u201388","journal-title":"Exp Neurol"},{"issue":"1","key":"5542_CR130","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1007\/s12035-012-8300-y","volume":"46","author":"K Leuner","year":"2012","unstructured":"Leuner K, Schulz K, Sch\u00fctt T, Pantel J, Prvulovic D, Rhein V et al (2012) Peripheral mitochondrial dysfunction in Alzheimer\u2019s disease: focus on lymphocytes. Mol Neurobiol 46(1):194\u2013204","journal-title":"Mol Neurobiol"},{"issue":"10","key":"5542_CR131","doi-asserted-by":"publisher","first-page":"793","DOI":"10.18632\/aging.100810","volume":"7","author":"S Maynard","year":"2015","unstructured":"Maynard S, Hejl A-M, Dinh T-ST, Keijzers G, Hansen \u00c5M, Desler C et al (2015) Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer\u2019s disease patients. Aging 7(10):793","journal-title":"Aging"},{"issue":"8","key":"5542_CR132","doi-asserted-by":"publisher","first-page":"930","DOI":"10.2174\/1567205013666160314150856","volume":"13","author":"Z Fisar","year":"2016","unstructured":"Fisar Z, Hroudov\u00e1 J, Hans\u00edkov\u00e1 H, Lelkov\u00e1 P, Wenchich L, Jir\u00e1k R et al (2016) Mitochondrial respiration in the platelets of patients with Alzheimer\u2019s disease. Curr Alzheimer Res 13(8):930\u2013941","journal-title":"Curr Alzheimer Res"},{"issue":"3","key":"5542_CR133","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S0304-3940(97)00738-6","volume":"235","author":"CC Smith","year":"1997","unstructured":"Smith CC (1997) Stimulated release of the \u03b2-amyloid protein of Alzheimer\u2019s disease by normal human platelets. Neurosci Lett 235(3):157\u2013159","journal-title":"Neurosci Lett"},{"issue":"6","key":"5542_CR134","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1007\/s11064-018-2657-x","volume":"44","author":"FA Prestia","year":"2019","unstructured":"Prestia FA, Galeano P, Martino Adami PV, Do Carmo S, Casta\u00f1o EM, Cuello AC et al (2019) Platelets bioenergetics screening reflects the impact of brain A\u03b2 plaque accumulation in a rat model of Alzheimer. Neurochem Res 44(6):1375\u20131386","journal-title":"Neurochem Res"},{"issue":"21","key":"5542_CR135","doi-asserted-by":"publisher","first-page":"3942","DOI":"10.1016\/j.jmb.2018.08.019","volume":"430","author":"SM Bell","year":"2018","unstructured":"Bell SM, Barnes K, Clemmens H, Al-Rafiah AR, Al-Ofi EA, Leech V et al (2018) Ursodeoxycholic acid improves mitochondrial function and redistributes Drp1 in fibroblasts from patients with either sporadic or familial Alzheimer\u2019s disease. J Mol Biol 430(21):3942\u20133953","journal-title":"J Mol Biol"},{"issue":"2","key":"5542_CR136","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3390\/jpm10020032","volume":"10","author":"SM Bell","year":"2020","unstructured":"Bell SM, De Marco M, Barnes K, Shaw PJ, Ferraiuolo L, Blackburn DJ et al (2020) Deficits in mitochondrial spare respiratory capacity contribute to the neuropsychological changes of Alzheimer\u2019s disease. J personalized Med 10(2):32","journal-title":"J personalized Med"},{"key":"5542_CR137","doi-asserted-by":"crossref","unstructured":"Yao J, Irwin RW, Zhao L, Nilsen J, Hamilton RT, Brinton RD (2009) Mitochondrial bioenergetic deficit precedes Alzheimer\u2019s pathology in female mouse model of Alzheimer\u2019s disease. Proceedings of the National Academy of Sciences. ;106(34):14670-5","DOI":"10.1073\/pnas.0903563106"},{"issue":"6","key":"5542_CR138","doi-asserted-by":"publisher","first-page":"3295","DOI":"10.1021\/pr300021e","volume":"11","author":"D Hartl","year":"2012","unstructured":"Hartl D, Schuldt V, Forler S, Zabel C, Klose J, Rohe M (2012) Presymptomatic alterations in energy metabolism and oxidative stress in the APP23 mouse model of Alzheimer disease. J Proteome Res 11(6):3295\u20133304","journal-title":"J Proteome Res"},{"issue":"4","key":"5542_CR139","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.jprot.2010.12.012","volume":"74","author":"JL Chou","year":"2011","unstructured":"Chou JL, Shenoy DV, Thomas N, Choudhary PK, LaFerla FM, Goodman SR et al (2011) Early dysregulation of the mitochondrial proteome in a mouse model of Alzheimer\u2019s disease. J Proteom 74(4):466\u2013479","journal-title":"J Proteom"},{"issue":"47","key":"5542_CR140","doi-asserted-by":"publisher","first-page":"20057","DOI":"10.1073\/pnas.0905529106","volume":"106","author":"V Rhein","year":"2009","unstructured":"Rhein V, Song X, Wiesner A, Ittner LM, Baysang G, Meier F et al (2009) Amyloid-\u03b2 and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer\u2019s disease mice. Proc Natl Acad Sci 106(47):20057\u201320062","journal-title":"Proc Natl Acad Sci"},{"issue":"3\u20134","key":"5542_CR141","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1159\/000113689","volume":"5","author":"A Eckert","year":"2008","unstructured":"Eckert A, Hauptmann S, Scherping I, Rhein V, M\u00fcller-Spahn F, G\u00f6tz J et al (2008) Soluble beta-amyloid leads to mitochondrial defects in amyloid precursor protein and tau transgenic mice. Neurodegenerative Dis 5(3\u20134):157\u2013159","journal-title":"Neurodegenerative Dis"},{"issue":"1","key":"5542_CR142","doi-asserted-by":"publisher","first-page":"9835","DOI":"10.1038\/s41598-017-10233-0","volume":"7","author":"MIG Lopez Sanchez","year":"2017","unstructured":"Lopez Sanchez MIG, Waugh HS, Tsatsanis A, Wong BX, Crowston JG, Duce JA et al (2017) Amyloid precursor protein drives down-regulation of mitochondrial oxidative phosphorylation independent of amyloid beta. Sci Rep 7(1):9835","journal-title":"Sci Rep"},{"issue":"8","key":"5542_CR143","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1096\/fj.00-0561fje","volume":"15","author":"SM Cardoso","year":"2001","unstructured":"Cardoso SM, Santos S, Swerdlow RH, Oliveira CR (2001) Functional mitochondria are required for amyloid \u03b2-mediated neurotoxicity. FASEB J 15(8):1439\u20131441","journal-title":"FASEB J"},{"issue":"2","key":"5542_CR144","doi-asserted-by":"publisher","first-page":"e32737","DOI":"10.1371\/journal.pone.0032737","volume":"7","author":"E Trushina","year":"2012","unstructured":"Trushina E, Nemutlu E, Zhang S, Christensen T, Camp J, Mesa J et al (2012) Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer\u2019s disease. PLoS ONE 7(2):e32737","journal-title":"PLoS ONE"},{"key":"5542_CR145","doi-asserted-by":"crossref","unstructured":"Wang X, Su B, Siedlak SL, Moreira PI, Fujioka H, Wang Y et al (2008) Amyloid-\u03b2 overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission\/fusion proteins. Proceedings of the National Academy of Sciences. ;105(49):19318-23","DOI":"10.1073\/pnas.0804871105"},{"issue":"4","key":"5542_CR146","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1097\/WNR.0000000000000739","volume":"28","author":"L-L Xu","year":"2017","unstructured":"Xu L-L, Shen Y, Wang X, Wei L-F, Wang P, Yang H et al (2017) Mitochondrial dynamics changes with age in an APPsw\/PS1dE9 mouse model of Alzheimer\u2019s disease. NeuroReport 28(4):222\u2013228","journal-title":"NeuroReport"},{"issue":"23","key":"5542_CR147","doi-asserted-by":"publisher","first-page":"4515","DOI":"10.1093\/hmg\/ddr381","volume":"20","author":"MJ Calkins","year":"2011","unstructured":"Calkins MJ, Manczak M, Mao P, Shirendeb U, Reddy PH (2011) Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer\u2019s disease. Hum Mol Genet 20(23):4515\u20134529","journal-title":"Hum Mol Genet"},{"issue":"1","key":"5542_CR148","doi-asserted-by":"publisher","first-page":"24756","DOI":"10.1038\/srep24756","volume":"6","author":"X-C Li","year":"2016","unstructured":"Li X-C, Hu Y, Wang Z-h, Luo Y, Zhang Y, Liu X-P et al (2016) Human wild-type full-length tau accumulation disrupts mitochondrial dynamics and the functions via increasing mitofusins. Sci Rep 6(1):24756","journal-title":"Sci Rep"},{"issue":"16","key":"5542_CR149","doi-asserted-by":"publisher","first-page":"3900","DOI":"10.1038\/sj.emboj.7601253","volume":"25","author":"MJ Barsoum","year":"2006","unstructured":"Barsoum MJ, Yuan H, Gerencser AA, Liot G, Kushnareva Y, Gr\u00e4ber S et al (2006) Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. EMBO J 25(16):3900","journal-title":"EMBO J"},{"issue":"5923","key":"5542_CR150","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1126\/science.1171091","volume":"324","author":"D-H Cho","year":"2009","unstructured":"Cho D-H, Nakamura T, Fang J, Cieplak P, Godzik A, Gu Z et al (2009) S-nitrosylation of Drp1 mediates \u03b2-amyloid-related mitochondrial fission and neuronal injury. Science 324(5923):102\u2013105","journal-title":"Science"},{"issue":"6","key":"5542_CR151","doi-asserted-by":"crossref","first-page":"a011072","DOI":"10.1101\/cshperspect.a011072","volume":"5","author":"AM Van der Bliek","year":"2013","unstructured":"Van der Bliek AM, Shen Q, Kawajiri S (2013) Mechanisms of mitochondrial fission and fusion. Cold Spring Harb Perspect Biol 5(6):a011072","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"8","key":"5542_CR152","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1093\/hmg\/ddy042","volume":"27","author":"M Manczak","year":"2018","unstructured":"Manczak M, Kandimalla R, Yin X, Reddy PH (2018) Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer\u2019s disease. Hum Mol Genet 27(8):1332\u20131342","journal-title":"Hum Mol Genet"},{"issue":"1","key":"5542_CR153","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/j.1365-2990.2009.01030.x","volume":"36","author":"J Simpson","year":"2010","unstructured":"Simpson J, Ince P, Haynes L, Theaker R, Gelsthorpe C, Baxter L et al (2010) Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain. Neuropathol Appl Neurobiol 36(1):25\u201340","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"2","key":"5542_CR154","doi-asserted-by":"publisher","first-page":"195","DOI":"10.3233\/JAD-2007-12210","volume":"12","author":"PI Moreira","year":"2007","unstructured":"Moreira PI, Harris PL, Zhu X, Santos MS, Oliveira CR, Smith MA et al (2007) Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts. J Alzheimer\u2019s Disease 12(2):195\u2013206","journal-title":"J Alzheimer\u2019s Disease"},{"issue":"8","key":"5542_CR155","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1093\/jnen\/60.8.759","volume":"60","author":"A Nunomura","year":"2001","unstructured":"Nunomura A, Perry G, Aliev G, Hirai K, Takeda A, Balraj EK et al (2001) Oxidative damage is the earliest event in Alzheimer disease. J Neuropathology Experimental Neurol 60(8):759\u2013767","journal-title":"J Neuropathology Experimental Neurol"},{"issue":"10","key":"5542_CR156","doi-asserted-by":"publisher","first-page":"2888","DOI":"10.1021\/bi035345j","volume":"43","author":"I Santa-Mar\u00eda","year":"2004","unstructured":"Santa-Mar\u00eda I, Hern\u00e1ndez F, Mart\u00edn CP, Avila J, Moreno FJ (2004) Quinones facilitate the self-assembly of the phosphorylated tubulin binding region of tau into fibrillar polymers. Biochemistry 43(10):2888\u20132897","journal-title":"Biochemistry"},{"issue":"8","key":"5542_CR157","doi-asserted-by":"publisher","first-page":"3270","DOI":"10.1073\/pnas.91.8.3270","volume":"91","author":"K Hensley","year":"1994","unstructured":"Hensley K, Carney J, Mattson M, Aksenova M, Harris M, Wu J et al (1994) A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease. Proc Natl Acad Sci 91(8):3270\u20133274","journal-title":"Proc Natl Acad Sci"},{"issue":"6","key":"5542_CR158","doi-asserted-by":"publisher","first-page":"610","DOI":"10.2174\/1567205013666151221145445","volume":"13","author":"S Beck","year":"2016","unstructured":"Beck S, Mufson JJ, Counts EE (2016) Evidence for mitochondrial UPR gene activation in familial and sporadic Alzheimer\u2019s disease. Curr Alzheimer Res 13(6):610\u2013614","journal-title":"Curr Alzheimer Res"},{"issue":"7684","key":"5542_CR159","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/nature25143","volume":"552","author":"V Sorrentino","year":"2017","unstructured":"Sorrentino V, Romani M, Mouchiroud L, Beck JS, Zhang H, D\u2019Amico D et al (2017) Enhancing mitochondrial proteostasis reduces amyloid-\u03b2 proteotoxicity. Nature 552(7684):187\u2013193","journal-title":"Nature"},{"key":"5542_CR160","doi-asserted-by":"publisher","first-page":"568","DOI":"10.3389\/fncel.2019.00568","volume":"13","author":"Y Shen","year":"2020","unstructured":"Shen Y, Ding M, Xie Z, Liu X, Yang H, Jin S et al (2020) Activation of mitochondrial unfolded protein response in SHSY5Y expressing APP cells and APP\/PS1 mice. Front Cell Neurosci 13:568","journal-title":"Front Cell Neurosci"},{"issue":"2","key":"5542_CR161","doi-asserted-by":"publisher","first-page":"227","DOI":"10.3390\/biomedicines9020227","volume":"9","author":"NS Leal","year":"2021","unstructured":"Leal NS, Martins LM (2021) Mind the Gap: Mitochondria and the Endoplasmic Reticulum in Neurodegenerative Diseases. Biomedicines [Internet] 9(2):227","journal-title":"Biomedicines [Internet]"},{"issue":"11","key":"5542_CR162","first-page":"1399","volume":"11","author":"P Bloomingdale","year":"2022","unstructured":"Bloomingdale P, Karelina T, Ramakrishnan V, Bakshi S, V\u00e9ronneau-Veilleux F, Moye M et al (2022) Hallmarks of neurodegenerative disease: A systems pharmacology perspective. CPT: Pharmacometrics Syst Pharmacol 11(11):1399\u20131429","journal-title":"CPT: Pharmacometrics Syst Pharmacol"},{"key":"5542_CR163","doi-asserted-by":"publisher","first-page":"666737","DOI":"10.3389\/fneur.2021.666737","volume":"12","author":"AN MacMahon Copas","year":"2021","unstructured":"MacMahon Copas AN, McComish SF, Fletcher JM, Caldwell MA (2021) The pathogenesis of Parkinson\u2019s disease: a complex interplay between astrocytes, microglia, and T lymphocytes? Front Neurol 12:666737","journal-title":"Front Neurol"},{"issue":"7886","key":"5542_CR164","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1038\/s41586-021-04059-0","volume":"599","author":"P Gonz\u00e1lez-Rodr\u00edguez","year":"2021","unstructured":"Gonz\u00e1lez-Rodr\u00edguez P, Zampese E, Stout KA, Guzman JN, Ilijic E, Yang B et al (2021) Disruption of mitochondrial complex I induces progressive parkinsonism. Nature 599(7886):650\u2013656","journal-title":"Nature"},{"key":"5542_CR165","doi-asserted-by":"publisher","first-page":"885500","DOI":"10.3389\/fnagi.2022.885500","volume":"14","author":"X-Y Gao","year":"2022","unstructured":"Gao X-Y, Yang T, Gu Y, Sun X-H (2022) Mitochondrial dysfunction in Parkinson\u2019s disease: from mechanistic insights to therapy. Front Aging Neurosci 14:885500","journal-title":"Front Aging Neurosci"},{"issue":"12","key":"5542_CR166","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1038\/81834","volume":"3","author":"R Betarbet","year":"2000","unstructured":"Betarbet R, Sherer TB, MacKenzie G, Garcia-Osuna M, Panov AV, Greenamyre JT (2000) Chronic systemic pesticide exposure reproduces features of Parkinson\u2019s disease. Nat Neurosci 3(12):1301\u20131306","journal-title":"Nat Neurosci"},{"issue":"4587","key":"5542_CR167","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1126\/science.6823561","volume":"219","author":"JW Langston","year":"1983","unstructured":"Langston JW, Ballard P, Tetrud JW, Irwin I (1983) Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219(4587):979\u2013980","journal-title":"Science"},{"key":"5542_CR168","doi-asserted-by":"crossref","unstructured":"Maegawa H, Niwa H (2021) Generation of mitochondrial toxin rodent models of Parkinson\u2019s disease using 6-OHDA, MPTP, and rotenone. Experimental Models of Parkinson\u2019s Disease. Springer, pp 95\u2013110","DOI":"10.1007\/978-1-0716-1495-2_10"},{"issue":"3","key":"5542_CR169","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/s00259-017-3844-8","volume":"45","author":"HS Yoo","year":"2018","unstructured":"Yoo HS, Chung SJ, Chung SJ, Moon H, Oh JS, Kim JS et al (2018) Presynaptic dopamine depletion determines the timing of levodopa-induced dyskinesia onset in Parkinson\u2019s disease. Eur J Nucl Med Mol Imaging 45(3):423\u2013431","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"10291","key":"5542_CR170","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","volume":"397","author":"BR Bloem","year":"2021","unstructured":"Bloem BR, Okun MS, Klein C (2021) Parkinson\u2019s disease. Lancet 397(10291):2284\u20132303","journal-title":"Lancet"},{"issue":"12","key":"5542_CR171","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1007\/s11064-018-2673-x","volume":"43","author":"TQ Melo","year":"2018","unstructured":"Melo TQ, Copray SJ, Ferrari MF (2018) Alpha-synuclein toxicity on protein quality control, mitochondria and endoplasmic reticulum. Neurochem Res 43(12):2212\u20132223","journal-title":"Neurochem Res"},{"issue":"11","key":"5542_CR172","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/s41419-019-2092-1","volume":"10","author":"M Vicario","year":"2019","unstructured":"Vicario M, Cieri D, Vallese F, Catoni C, Barazzuol L, Berto P et al (2019) A split-GFP tool reveals differences in the sub-mitochondrial distribution of wt and mutant alpha-synuclein. Cell Death Dis 10(11):857","journal-title":"Cell Death Dis"},{"issue":"9","key":"5542_CR173","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.3390\/cells8091072","volume":"8","author":"T Cal\u00ec","year":"2019","unstructured":"Cal\u00ec T, Ottolini D, Vicario M, Catoni C, Vallese F, Cieri D et al (2019) splitGFP technology reveals dose-dependent ER-mitochondria interface modulation by \u03b1-synuclein A53T and A30P mutants. Cells 8(9):1072","journal-title":"Cells"},{"issue":"11","key":"5542_CR174","doi-asserted-by":"publisher","first-page":"2932","DOI":"10.1002\/jnr.24952","volume":"99","author":"AG Erustes","year":"2021","unstructured":"Erustes AG, D\u2019Eletto M, Guarache GC, Ureshino RP, Bincoletto C, da Silva Pereira GJ et al (2021) Overexpression of \u03b1-synuclein inhibits mitochondrial Ca2\u2009+\u2009trafficking between the endoplasmic reticulum and mitochondria through MAMs by altering the GRP75\u2013IP3R interaction. J Neurosci Res 99(11):2932\u20132947","journal-title":"J Neurosci Res"},{"issue":"8","key":"5542_CR175","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.molmed.2015.05.004","volume":"21","author":"J-M Taymans","year":"2015","unstructured":"Taymans J-M, Nkiliza A, Chartier-Harlin M-C (2015) Deregulation of protein translation control, a potential game-changing hypothesis for Parkinson\u2019s disease pathogenesis. Trends Mol Med 21(8):466\u2013472","journal-title":"Trends Mol Med"},{"issue":"1","key":"5542_CR176","doi-asserted-by":"publisher","first-page":"17293","DOI":"10.1038\/s41598-020-74195-6","volume":"10","author":"C Gonzalez-Hunt","year":"2020","unstructured":"Gonzalez-Hunt C, Thacker E, Toste C, Boularand S, Deprets S, Dubois L et al (2020) Mitochondrial DNA damage as a potential biomarker of LRRK2 kinase activity in LRRK2 Parkinson\u2019s disease. Sci Rep 10(1):17293","journal-title":"Sci Rep"},{"issue":"8","key":"5542_CR177","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1093\/hmg\/ddt600","volume":"23","author":"K Stafa","year":"2014","unstructured":"Stafa K, Tsika E, Moser R, Musso A, Glauser L, Jones A et al (2014) Functional interaction of Parkinson\u2019s disease-associated LRRK2 with members of the dynamin GTPase superfamily. Hum Mol Genet 23(8):2055\u20132077","journal-title":"Hum Mol Genet"},{"issue":"11","key":"5542_CR178","doi-asserted-by":"publisher","first-page":"783","DOI":"10.3390\/brainsci10110783","volume":"10","author":"Y-R Wu","year":"2020","unstructured":"Wu Y-R, Lin C-H, Chao C-Y, Chang C-W, Chen C-M, Lee-Chen G-J (2020) Rare VPS35 A320V variant in Taiwanese Parkinson\u2019s disease indicates disrupted CI-MPR sorting and impaired mitochondrial morphology. Brain Sci 10(11):783","journal-title":"Brain Sci"},{"issue":"6","key":"5542_CR179","doi-asserted-by":"publisher","first-page":"2014","DOI":"10.1038\/s41418-019-0482-7","volume":"27","author":"W Liu","year":"2020","unstructured":"Liu W, Duan X, Xu L, Shang W, Zhao J, Wang L et al (2020) Chchd2 regulates mitochondrial morphology by modulating the levels of Opa1. Cell Death Differ 27(6):2014\u20132029","journal-title":"Cell Death Differ"},{"issue":"26","key":"5542_CR180","doi-asserted-by":"publisher","first-page":"10300","DOI":"10.1074\/jbc.RA118.006302","volume":"294","author":"F Koyano","year":"2019","unstructured":"Koyano F, Yamano K, Kosako H, Tanaka K, Matsuda N (2019) Parkin recruitment to impaired mitochondria for nonselective ubiquitylation is facilitated by MITOL. J Biol Chem 294(26):10300\u201310314","journal-title":"J Biol Chem"},{"issue":"4","key":"5542_CR181","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.tibs.2020.11.007","volume":"46","author":"AB Malpartida","year":"2021","unstructured":"Malpartida AB, Williamson M, Narendra DP, Wade-Martins R, Ryan BJ (2021) Mitochondrial dysfunction and mitophagy in Parkinson\u2019s disease: from mechanism to therapy. Trends Biochem Sci 46(4):329\u2013343","journal-title":"Trends Biochem Sci"},{"key":"5542_CR182","doi-asserted-by":"publisher","first-page":"e32866","DOI":"10.7554\/eLife.32866","volume":"7","author":"G-L McLelland","year":"2018","unstructured":"McLelland G-L, Goiran T, Yi W, Dorval G, Chen CX, Lauinger ND et al (2018) Mfn2 ubiquitination by PINK1\/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy. elife 7:e32866","journal-title":"elife"},{"key":"5542_CR183","doi-asserted-by":"publisher","first-page":"885500","DOI":"10.3389\/fnagi.2022.885500","volume":"14","author":"XY Gao","year":"2022","unstructured":"Gao XY, Yang T, Gu Y, Sun XH (2022) Mitochondrial Dysfunction in Parkinson\u2019s Disease: From Mechanistic Insights to Therapy. Front Aging Neurosci 14:885500","journal-title":"Front Aging Neurosci"},{"issue":"2","key":"5542_CR184","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.cell.2016.05.039","volume":"166","author":"D Matheoud","year":"2016","unstructured":"Matheoud D, Sugiura A, Bellemare-Pelletier A, Laplante A, Rondeau C, Chemali M et al (2016) Parkinson\u2019s disease-related proteins PINK1 and Parkin repress mitochondrial antigen presentation. Cell 166(2):314\u2013327","journal-title":"Cell"},{"key":"5542_CR185","doi-asserted-by":"publisher","first-page":"116413","DOI":"10.1016\/j.envpol.2020.116413","volume":"272","author":"N Chen","year":"2021","unstructured":"Chen N, Guo Z, Luo Z, Zheng F, Shao W, Yu G et al (2021) Drp1-mediated mitochondrial fission contributes to mitophagy in paraquat-induced neuronal cell damage. Environ Pollut 272:116413","journal-title":"Environ Pollut"},{"issue":"1","key":"5542_CR186","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1038\/nm.3983","volume":"22","author":"W Wang","year":"2016","unstructured":"Wang W, Wang X, Fujioka H, Hoppel C, Whone AL, Caldwell MA et al (2016) Parkinson\u2019s disease\u2013associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes. Nat Med 22(1):54\u201363","journal-title":"Nat Med"},{"issue":"1","key":"5542_CR187","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s00401-017-1704-z","volume":"134","author":"S Paillusson","year":"2017","unstructured":"Paillusson S, Gomez-Suaga P, Stoica R, Little D, Gissen P, Devine MJ et al (2017) \u03b1-Synuclein binds to the ER\u2013mitochondria tethering protein VAPB to disrupt Ca2\u2009+\u2009homeostasis and mitochondrial ATP production. Acta Neuropathol 134(1):129\u2013149","journal-title":"Acta Neuropathol"},{"issue":"1","key":"5542_CR188","doi-asserted-by":"publisher","first-page":"16441","DOI":"10.1038\/s41598-017-16637-2","volume":"7","author":"JF Cooper","year":"2017","unstructured":"Cooper JF, Machiela E, Dues DJ, Spielbauer KK, Senchuk MM, Van Raamsdonk JM (2017) Activation of the mitochondrial unfolded protein response promotes longevity and dopamine neuron survival in Parkinson\u2019s disease models. Sci Rep 7(1):16441","journal-title":"Sci Rep"},{"key":"5542_CR189","doi-asserted-by":"publisher","first-page":"112213","DOI":"10.1016\/j.jep.2019.112213","volume":"247","author":"M Liu","year":"2020","unstructured":"Liu M, Yu S, Wang J, Qiao J, Liu Y, Wang S et al (2020) Ginseng protein protects against mitochondrial dysfunction and neurodegeneration by inducing mitochondrial unfolded protein response in Drosophila melanogaster PINK1 model of Parkinson\u2019s disease. J Ethnopharmacol 247:112213","journal-title":"J Ethnopharmacol"},{"issue":"46","key":"5542_CR190","doi-asserted-by":"publisher","first-page":"11085","DOI":"10.1523\/JNEUROSCI.1294-17.2017","volume":"37","author":"BA Martinez","year":"2017","unstructured":"Martinez BA, Petersen DA, Gaeta AL, Stanley SP, Caldwell GA, Caldwell KA (2017) Dysregulation of the mitochondrial unfolded protein response induces non-apoptotic dopaminergic neurodegeneration in C. elegans models of Parkinson\u2019s disease. J Neurosci 37(46):11085\u201311100","journal-title":"J Neurosci"},{"issue":"2","key":"5542_CR191","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/S1474-4422(19)30287-X","volume":"19","author":"C Blauwendraat","year":"2020","unstructured":"Blauwendraat C, Nalls MA, Singleton AB (2020) The genetic architecture of Parkinson\u2019s disease. Lancet Neurol 19(2):170\u2013178","journal-title":"Lancet Neurol"},{"issue":"2","key":"5542_CR192","doi-asserted-by":"publisher","first-page":"EMBJ2018100875","DOI":"10.15252\/embj.2018100875","volume":"39","author":"T Toyofuku","year":"2020","unstructured":"Toyofuku T, Okamoto Y, Ishikawa T, Sasawatari S, Kumanogoh A (2020) LRRK2 regulates endoplasmic reticulum\u2013mitochondrial tethering through the PERK-mediated ubiquitination pathway. EMBO J 39(2):EMBJ2018100875","journal-title":"EMBO J"},{"issue":"14","key":"5542_CR193","first-page":"2972","volume":"25","author":"CA Gautier","year":"2016","unstructured":"Gautier CA, Erpapazoglou Z, Mouton-Liger F, Muriel MP, Cormier F, Bigou S et al (2016) The endoplasmic reticulum-mitochondria interface is perturbed in PARK2 knockout mice and patients with PARK2 mutations. Hum Mol Genet 25(14):2972\u20132984","journal-title":"Hum Mol Genet"},{"issue":"6","key":"5542_CR194","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.tig.2018.03.001","volume":"34","author":"HP Nguyen","year":"2018","unstructured":"Nguyen HP, Van Broeckhoven C, van der Zee J (2018) ALS genes in the genomic era and their implications for FTD. Trends Genet 34(6):404\u2013423","journal-title":"Trends Genet"},{"issue":"5","key":"5542_CR195","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/S1474-4422(21)00414-2","volume":"21","author":"SA Goutman","year":"2022","unstructured":"Goutman SA, Hardiman O, Al-Chalabi A, Chi\u00f3 A, Savelieff MG, Kiernan MC et al (2022) Emerging insights into the complex genetics and pathophysiology of amyotrophic lateral sclerosis. Lancet Neurol 21(5):465\u2013479","journal-title":"Lancet Neurol"},{"issue":"3","key":"5542_CR196","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.cmet.2021.01.005","volume":"33","author":"T Wang","year":"2021","unstructured":"Wang T, Liu H, Itoh K, Oh S, Zhao L, Murata D et al (2021) C9orf72 regulates energy homeostasis by stabilizing mitochondrial complex I assembly. Cell Metabol 33(3):531\u2013546 e9","journal-title":"Cell Metabol"},{"issue":"3","key":"5542_CR197","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.nbd.2006.01.001","volume":"22","author":"SE Browne","year":"2006","unstructured":"Browne SE, Yang L, DiMauro J-P, Fuller SW, Licata SC, Beal MF (2006) Bioenergetic abnormalities in discrete cerebral motor pathways presage spinal cord pathology in the G93A SOD1 mouse model of ALS. Neurobiol Dis 22(3):599\u2013610","journal-title":"Neurobiol Dis"},{"issue":"3","key":"5542_CR198","first-page":"109","volume":"5","author":"M Babbar","year":"2013","unstructured":"Babbar M, Sheikh MS (2013) Metabolic stress and disorders related to alterations in mitochondrial fission or fusion. Mol Cell Pharmacol 5(3):109","journal-title":"Mol Cell Pharmacol"},{"issue":"9","key":"5542_CR199","doi-asserted-by":"publisher","first-page":"4705","DOI":"10.3390\/ijms22094705","volume":"22","author":"A Wood","year":"2021","unstructured":"Wood A, Gurfinkel Y, Polain N, Lamont W, Lyn Rea S (2021) Molecular mechanisms underlying TDP-43 pathology in cellular and animal models of ALS and FTLD. Int J Mol Sci 22(9):4705","journal-title":"Int J Mol Sci"},{"issue":"1","key":"5542_CR200","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/cns.12655","volume":"23","author":"M Golpich","year":"2017","unstructured":"Golpich M, Amini E, Mohamed Z, Azman Ali R, Mohamed Ibrahim N, Ahmadiani A (2017) Mitochondrial dysfunction and biogenesis in neurodegenerative diseases: pathogenesis and treatment. CNS Neurosci Ther 23(1):5\u201322","journal-title":"CNS Neurosci Ther"},{"issue":"22","key":"5542_CR201","doi-asserted-by":"publisher","first-page":"4529","DOI":"10.1093\/hmg\/ddq383","volume":"19","author":"A Ferri","year":"2010","unstructured":"Ferri A, Fiorenzo P, Nencini M, Cozzolino M, Pesaresi MG, Valle C et al (2010) Glutaredoxin 2 prevents aggregation of mutant SOD1 in mitochondria and abolishes its toxicity. Hum Mol Genet 19(22):4529\u20134542","journal-title":"Hum Mol Genet"},{"issue":"1","key":"5542_CR202","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s40478-018-0564-7","volume":"6","author":"N Sakae","year":"2018","unstructured":"Sakae N, Bieniek KF, Zhang Y-J, Ross K, Gendron TF, Murray ME et al (2018) Poly-GR dipeptide repeat polymers correlate with neurodegeneration and Clinicopathological subtypes in C9ORF72-related brain disease. Acta Neuropathol Commun 6(1):63","journal-title":"Acta Neuropathol Commun"},{"issue":"12","key":"5542_CR203","doi-asserted-by":"publisher","first-page":"6352","DOI":"10.3390\/ijms22126352","volume":"22","author":"E Obrador","year":"2021","unstructured":"Obrador E, Salvador-Palmer R, L\u00f3pez-Blanch R, Jihad-Jebbar A, Vall\u00e9s SL, Estrela JM (2021) The link between oxidative stress, redox status, bioenergetics and mitochondria in the pathophysiology of ALS. Int J Mol Sci 22(12):6352","journal-title":"Int J Mol Sci"},{"issue":"1","key":"5542_CR204","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s40478-016-0316-5","volume":"4","author":"E Onesto","year":"2016","unstructured":"Onesto E, Colombrita C, Gumina V, Borghi MO, Dusi S, Doretti A et al (2016) Gene-specific mitochondria dysfunctions in human TARDBP and C9ORF72 fibroblasts. Acta Neuropathol Commun 4(1):47","journal-title":"Acta Neuropathol Commun"},{"issue":"32","key":"5542_CR205","doi-asserted-by":"publisher","first-page":"10851","DOI":"10.1523\/JNEUROSCI.1630-10.2010","volume":"30","author":"Y-F Xu","year":"2010","unstructured":"Xu Y-F, Gendron TF, Zhang Y-J, Lin W-L, D\u2019Alton S, Sheng H et al (2010) Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice. J Neurosci 30(32):10851\u201310859","journal-title":"J Neurosci"},{"issue":"2","key":"5542_CR206","first-page":"183","volume":"61","author":"J Walczak","year":"2015","unstructured":"Walczak J, Szczepanowska J (2015) Dysfunction of mitochondrial dynamic and distribution in amyotrophic lateral sclerosis. Postepy Biochem 61(2):183\u2013190","journal-title":"Postepy Biochem"},{"key":"5542_CR207","doi-asserted-by":"publisher","first-page":"103396","DOI":"10.1016\/j.mcn.2019.103396","volume":"100","author":"J Gao","year":"2019","unstructured":"Gao J, Wang L, Yan T, Perry G, Wang X (2019) TDP-43 proteinopathy and mitochondrial abnormalities in neurodegeneration. Mol Cell Neurosci 100:103396","journal-title":"Mol Cell Neurosci"},{"key":"5542_CR208","doi-asserted-by":"crossref","unstructured":"Wong YC, Holzbaur EL (2014) Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation. Proceedings of the National Academy of Sciences. ;111(42):E4439-E48","DOI":"10.1073\/pnas.1405752111"},{"issue":"7","key":"5542_CR209","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1080\/15548627.2016.1170257","volume":"12","author":"A Goode","year":"2016","unstructured":"Goode A, Butler K, Long J, Cavey J, Scott D, Shaw B et al (2016) Defective recognition of LC3B by mutant SQSTM1\/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD. Autophagy 12(7):1094\u20131104","journal-title":"Autophagy"},{"key":"5542_CR210","doi-asserted-by":"publisher","first-page":"100301","DOI":"10.1016\/j.ensci.2020.100301","volume":"22","author":"M Nozaki","year":"2021","unstructured":"Nozaki M, Otomo A, Mitsui S, Ono S, Shirakawa R, Chen Y et al (2021) SQSTM1L341V variant that is linked to sporadic ALS exhibits impaired association with MAP1LC3 in cultured cells. Eneurologicalsci 22:100301","journal-title":"Eneurologicalsci"},{"key":"5542_CR211","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3389\/fphys.2020.00063","volume":"11","author":"S Carrera-Juli\u00e1","year":"2020","unstructured":"Carrera-Juli\u00e1 S, Moreno ML, Barrios C, de la Rubia Ort\u00ed JE, Drehmer E (2020) Antioxidant alternatives in the treatment of amyotrophic lateral sclerosis: a comprehensive review. Front Physiol 11:63","journal-title":"Front Physiol"},{"issue":"2","key":"5542_CR212","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1002\/ana.410390210","volume":"39","author":"L Sikl\u00f3s","year":"1996","unstructured":"Sikl\u00f3s L, Engelhardt J, Harati Y, Smith RG, Jo\u00f3 F, Appel SH (1996) Ultrastructural evidence for altered calcium in motor nerve terminals in amyotrophc lateral sclerosis. Ann Neurol 39(2):203\u2013216","journal-title":"Ann Neurol"},{"issue":"9","key":"5542_CR213","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.15252\/embr.201541726","volume":"17","author":"R Stoica","year":"2016","unstructured":"Stoica R, Paillusson S, Gomez-Suaga P, Mitchell JC, Lau DH, Gray EH et al (2016) ALS\/FTD\u2010associated FUS activates GSK\u20103\u03b2 to disrupt the VAPB\u2013PTPIP51 interaction and ER\u2013mitochondria associations. EMBO Rep 17(9):1326\u20131342","journal-title":"EMBO Rep"},{"issue":"9","key":"5542_CR214","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1093\/hmg\/dds011","volume":"21","author":"GM Morotz","year":"2012","unstructured":"Morotz GM, De Vos KJ, Vagnoni A, Ackerley S, Shaw CE, Miller CC (2012) Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria. Hum Mol Genet 21(9):1979\u20131988","journal-title":"Hum Mol Genet"},{"issue":"6","key":"5542_CR215","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/j.neurobiolaging.2008.07.005","volume":"31","author":"G Anagnostou","year":"2010","unstructured":"Anagnostou G, Akbar MT, Paul P, Angelinetta C, Steiner TJ, de Belleroche J (2010) Vesicle associated membrane protein B (VAPB) is decreased in ALS spinal cord. Neurobiol Aging 31(6):969\u2013985","journal-title":"Neurobiol Aging"},{"key":"5542_CR216","doi-asserted-by":"publisher","first-page":"132933","DOI":"10.1016\/j.neulet.2017.06.052","volume":"710","author":"EF Smith","year":"2019","unstructured":"Smith EF, Shaw PJ, De Vos KJ (2019) The role of mitochondria in amyotrophic lateral sclerosis. Neurosci Lett 710:132933","journal-title":"Neurosci Lett"},{"issue":"6","key":"5542_CR217","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1038\/s41593-019-0397-0","volume":"22","author":"SY Choi","year":"2019","unstructured":"Choi SY, Lopez-Gonzalez R, Krishnan G, Phillips HL, Li AN, Seeley WW et al (2019) C9ORF72-ALS\/FTD-associated poly (GR) binds Atp5a1 and compromises mitochondrial function in vivo. Nat Neurosci 22(6):851\u2013862","journal-title":"Nat Neurosci"},{"issue":"1","key":"5542_CR218","doi-asserted-by":"publisher","first-page":"3996","DOI":"10.1038\/ncomms4996","volume":"5","author":"R Stoica","year":"2014","unstructured":"Stoica R, De Vos KJ, Paillusson S, Mueller S, Sancho RM, Lau K-F et al (2014) ER\u2013mitochondria associations are regulated by the VAPB\u2013PTPIP51 interaction and are disrupted by ALS\/FTD-associated TDP-43. Nat Commun 5(1):3996","journal-title":"Nat Commun"},{"issue":"42","key":"5542_CR219","doi-asserted-by":"publisher","first-page":"10633","DOI":"10.1523\/JNEUROSCI.4084-06.2006","volume":"26","author":"M Watabe-Uchida","year":"2006","unstructured":"Watabe-Uchida M, Govek E-E, Van Aelst L (2006) Regulators of Rho GTPases in neuronal development. J Neurosci 26(42):10633\u201310635","journal-title":"J Neurosci"},{"key":"5542_CR220","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.neulet.2013.12.005","volume":"559","author":"Y Ono","year":"2014","unstructured":"Ono Y, Tanaka H, Takata M, Nagahara Y, Noda Y, Tsuruma K et al (2014) SA4503, a sigma-1 receptor agonist, suppresses motor neuron damage in in vitro and in vivo amyotrophic lateral sclerosis models. Neurosci Lett 559:174\u2013178","journal-title":"Neurosci Lett"},{"issue":"5","key":"5542_CR221","doi-asserted-by":"publisher","first-page":"e646","DOI":"10.1038\/cddis.2013.170","volume":"4","author":"A Hyrskyluoto","year":"2013","unstructured":"Hyrskyluoto A, Pulli I, T\u00f6rnqvist K, Huu Ho T, Korhonen L, Lindholm D (2013) Sigma-1 receptor agonist PRE084 is protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-\u03baB pathway. Cell Death Dis 4(5):e646\u2013e","journal-title":"Cell Death Dis"},{"issue":"10","key":"5542_CR222","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1038\/s41582-020-0389-4","volume":"16","author":"SJ Tabrizi","year":"2020","unstructured":"Tabrizi SJ, Flower MD, Ross CA, Wild EJ (2020) Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities. Nat Reviews Neurol 16(10):529\u2013546","journal-title":"Nat Reviews Neurol"},{"issue":"20","key":"5542_CR223","doi-asserted-by":"publisher","first-page":"3919","DOI":"10.1093\/hmg\/ddq306","volume":"19","author":"J Kim","year":"2010","unstructured":"Kim J, Moody JP, Edgerly CK, Bordiuk OL, Cormier K, Smith K et al (2010) Mitochondrial loss, dysfunction and altered dynamics in Huntington\u2019s disease. Hum Mol Genet 19(20):3919\u20133935","journal-title":"Hum Mol Genet"},{"issue":"7","key":"5542_CR224","doi-asserted-by":"publisher","first-page":"a024240","DOI":"10.1101\/cshperspect.a024240","volume":"7","author":"M Jimenez-Sanchez","year":"2017","unstructured":"Jimenez-Sanchez M, Licitra F, Underwood BR, Rubinsztein DC (2017) Huntington\u2019s disease: mechanisms of pathogenesis and therapeutic strategies. Cold Spring Harbor Perspect Med 7(7):a024240","journal-title":"Cold Spring Harbor Perspect Med"},{"issue":"1","key":"5542_CR225","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S1474-4422(10)70245-3","volume":"10","author":"CA Ross","year":"2011","unstructured":"Ross CA, Tabrizi SJ (2011) Huntington\u2019s disease: from molecular pathogenesis to clinical treatment. Lancet Neurol 10(1):83\u201398","journal-title":"Lancet Neurol"},{"issue":"11","key":"5542_CR226","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1089\/ars.2012.4928","volume":"19","author":"F Haun","year":"2013","unstructured":"Haun F, Nakamura T, Shiu AD, Cho D-H, Tsunemi T, Holland EA et al (2013) S-nitrosylation of dynamin-related protein 1 mediates mutant huntingtin-induced mitochondrial fragmentation and neuronal injury in Huntington\u2019s disease. Antioxid Redox Signal 19(11):1173\u20131184","journal-title":"Antioxid Redox Signal"},{"issue":"2","key":"5542_CR227","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1093\/hmg\/ddx394","volume":"27","author":"DE Ehrnhoefer","year":"2018","unstructured":"Ehrnhoefer DE, Southwell AL, Sivasubramanian M, Qiu X, Villanueva EB, Xie Y et al (2018) HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo. Hum Mol Genet 27(2):239\u2013253","journal-title":"Hum Mol Genet"},{"issue":"1","key":"5542_CR228","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1196\/annals.1427.008","volume":"1147","author":"EC Stack","year":"2008","unstructured":"Stack EC, Matson WR, Ferrante RJ (2008) Evidence of oxidant damage in Huntington\u2019s disease: translational strategies using antioxidants. Ann N Y Acad Sci 1147(1):79\u201392","journal-title":"Ann N Y Acad Sci"},{"issue":"5","key":"5542_CR229","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1002\/ana.410410514","volume":"41","author":"SE Browne","year":"1997","unstructured":"Browne SE, Bowling AC, Macgarvey U, Baik MJ, Berger SC, Muquit MM et al (1997) Oxidative damage and metabolic dysfunction in Huntington\u2019s disease: selective vulnerability of the basal ganglia. Annals Neurology: Official J Am Neurol Association Child Neurol Soc 41(5):646\u2013653","journal-title":"Annals Neurology: Official J Am Neurol Association Child Neurol Soc"},{"key":"5542_CR230","doi-asserted-by":"publisher","first-page":"104741","DOI":"10.1016\/j.nbd.2020.104741","volume":"136","author":"M Cherubini","year":"2020","unstructured":"Cherubini M, Lopez-Molina L, Gines S (2020) Mitochondrial fission in Huntington\u2019s disease mouse striatum disrupts ER-mitochondria contacts leading to disturbances in Ca2\u2009+\u2009efflux and Reactive Oxygen Species (ROS) homeostasis. Neurobiol Dis 136:104741","journal-title":"Neurobiol Dis"},{"issue":"25","key":"5542_CR231","doi-asserted-by":"publisher","first-page":"7308","DOI":"10.1093\/hmg\/ddv429","volume":"24","author":"M Manczak","year":"2015","unstructured":"Manczak M, Reddy PH (2015) Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington\u2019s disease. Hum Mol Genet 24(25):7308\u20137325","journal-title":"Hum Mol Genet"},{"issue":"9","key":"5542_CR232","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1093\/hmg\/ddw045","volume":"25","author":"X Yin","year":"2016","unstructured":"Yin X, Manczak M, Reddy PH (2016) Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington\u2019s disease. Hum Mol Genet 25(9):1739\u20131753","journal-title":"Hum Mol Genet"},{"key":"5542_CR233","doi-asserted-by":"crossref","unstructured":"Bioenergetic (2020) deficits in Huntington\u2019s disease iPSC-derived neural cells and rescue with glycolytic metabolites. Human molecular genetics. ;29(11):1757-71","DOI":"10.1093\/hmg\/ddy430"},{"issue":"2","key":"5542_CR234","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1080\/1028415X.2016.1237074","volume":"21","author":"M Orozco-Ibarra","year":"2018","unstructured":"Orozco-Ibarra M, Garc\u00eda-Morales J, Calvo-Silva FJ, Fern\u00e1ndez-Valverde F, Serrano-Garc\u00eda N (2018) Striatal mitochondria response to 3-nitropropionic acid and fish oil treatment. Nutr Neurosci 21(2):132\u2013142","journal-title":"Nutr Neurosci"},{"issue":"7","key":"5542_CR235","doi-asserted-by":"publisher","first-page":"e15851","DOI":"10.15252\/emmm.202215851","volume":"14","author":"C Liu","year":"2022","unstructured":"Liu C, Fu Z, Wu S, Wang X, Zhang S, Chu C et al (2022) Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington\u2019s disease. EMBO Mol Med 14(7):e15851","journal-title":"EMBO Mol Med"},{"issue":"4","key":"5542_CR236","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.1091\/mbc.e05-07-0607","volume":"17","author":"A Benchoua","year":"2006","unstructured":"Benchoua A, Trioulier Y, Zala D, Gaillard M-C, Lefort N, Dufour N et al (2006) Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin. Mol Biol Cell 17(4):1652\u20131663","journal-title":"Mol Biol Cell"},{"issue":"3","key":"5542_CR237","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1111\/jnc.12739","volume":"130","author":"M Muller","year":"2014","unstructured":"Muller M, Leavitt BR (2014) Iron dysregulation in Huntington\u2019s disease. J Neurochem 130(3):328\u2013350","journal-title":"J Neurochem"},{"key":"5542_CR238","doi-asserted-by":"crossref","unstructured":"Fu Z, Liu F, Liu C, Jin B, Jiang Y, Tang M et al (2019) Mutant huntingtin inhibits the mitochondrial unfolded protein response by impairing ABCB10 mRNA stability. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. 1865(6):1428\u20131435","DOI":"10.1016\/j.bbadis.2019.02.015"},{"issue":"7","key":"5542_CR239","doi-asserted-by":"publisher","first-page":"5385","DOI":"10.1007\/s12035-016-0048-3","volume":"54","author":"L Naia","year":"2017","unstructured":"Naia L, Rosenstock TR, Oliveira AM, Oliveira-Sousa SI, Caldeira GL, Carmo C et al (2017) Comparative mitochondrial-based protective effects of resveratrol and nicotinamide in Huntington\u2019s disease models. Mol Neurobiol 54(7):5385\u20135399","journal-title":"Mol Neurobiol"},{"issue":"4","key":"5542_CR240","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1016\/j.bbrc.2016.07.122","volume":"483","author":"L Naia","year":"2017","unstructured":"Naia L, Ferreira IL, Ferreiro E, Rego AC (2017) Mitochondrial Ca2\u2009+\u2009handling in Huntington\u2019s and Alzheimer\u2019s diseases\u2013Role of ER-mitochondria crosstalk. Biochem Biophys Res Commun 483(4):1069\u20131077","journal-title":"Biochem Biophys Res Commun"},{"issue":"9","key":"5542_CR241","doi-asserted-by":"publisher","first-page":"5780","DOI":"10.1074\/jbc.M704704200","volume":"283","author":"D Lim","year":"2008","unstructured":"Lim D, Fedrizzi L, Tartari M, Zuccato C, Cattaneo E, Brini M et al (2008) Calcium homeostasis and mitochondrial dysfunction in striatal neurons of Huntington disease. J Biol Chem 283(9):5780\u20135789","journal-title":"J Biol Chem"},{"issue":"4","key":"5542_CR242","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1016\/j.bbrc.2004.08.035","volume":"322","author":"I Bezprozvanny","year":"2004","unstructured":"Bezprozvanny I, Hayden MR (2004) Deranged neuronal calcium signaling and Huntington disease. Biochem Biophys Res Commun 322(4):1310\u20131317","journal-title":"Biochem Biophys Res Commun"},{"key":"5542_CR243","doi-asserted-by":"publisher","first-page":"132932","DOI":"10.1016\/j.neulet.2017.06.051","volume":"710","author":"D Bargiela","year":"2019","unstructured":"Bargiela D, Chinnery PF (2019) Mitochondria in neuroinflammation\u2013Multiple sclerosis (MS), leber hereditary optic neuropathy (LHON) and LHON-MS. Neurosci Lett 710:132932","journal-title":"Neurosci Lett"},{"issue":"1","key":"5542_CR244","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s12192-019-01049-0","volume":"25","author":"C Pistono","year":"2020","unstructured":"Pistono C, Monti MC, Boiocchi C, Berzolari FG, Osera C, Mallucci G et al (2020) Response to oxidative stress of peripheral blood mononuclear cells from multiple sclerosis patients and healthy controls. Cell Stress Chaperones 25(1):81\u201391","journal-title":"Cell Stress Chaperones"},{"issue":"1","key":"5542_CR245","first-page":"725370","volume":"2015","author":"L Haider","year":"2015","unstructured":"Haider L (2015) Inflammation, iron, energy failure, and oxidative stress in the pathogenesis of multiple sclerosis. Oxidative Med Cell Longev 2015(1):725370","journal-title":"Oxidative Med Cell Longev"},{"key":"5542_CR246","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/bs.ircmb.2016.08.003","volume":"328","author":"S Patergnani","year":"2017","unstructured":"Patergnani S, Fossati V, Bonora M, Giorgi C, Marchi S, Missiroli S et al (2017) Mitochondria in multiple sclerosis: molecular mechanisms of pathogenesis. Int Rev cell Mol biology 328:49\u2013103","journal-title":"Int Rev cell Mol biology"},{"issue":"5","key":"5542_CR247","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1093\/brain\/awp046","volume":"132","author":"DJ Mahad","year":"2009","unstructured":"Mahad DJ, Ziabreva I, Campbell G, Lax N, White K, Hanson PS et al (2009) Mitochondrial changes within axons in multiple sclerosis. Brain 132(5):1161\u20131174","journal-title":"Brain"},{"issue":"11","key":"5542_CR248","doi-asserted-by":"publisher","first-page":"2800","DOI":"10.1093\/brain\/awm236","volume":"130","author":"C Marik","year":"2007","unstructured":"Marik C, Felts PA, Bauer J, Lassmann H, Smith KJ (2007) Lesion genesis in a subset of patients with multiple sclerosis: a role for innate immunity? Brain 130(11):2800\u20132815","journal-title":"Brain"},{"issue":"14","key":"5542_CR249","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1177\/1352458514544537","volume":"20","author":"GR Campbell","year":"2014","unstructured":"Campbell GR, Worrall JT, Mahad DJ (2014) The central role of mitochondria in axonal degeneration in multiple sclerosis. Multiple Scler J 20(14):1806\u20131813","journal-title":"Multiple Scler J"},{"issue":"2","key":"5542_CR250","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s00401-020-02179-x","volume":"140","author":"S Licht-Mayer","year":"2020","unstructured":"Licht-Mayer S, Campbell GR, Canizares M, Mehta AR, Gane AB, McGill K et al (2020) Enhanced axonal response of mitochondria to demyelination offers neuroprotection: implications for multiple sclerosis. Acta Neuropathol 140(2):143\u2013167","journal-title":"Acta Neuropathol"},{"issue":"6","key":"5542_CR251","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1093\/brain\/124.6.1114","volume":"124","author":"B Kornek","year":"2001","unstructured":"Kornek B, Storch MK, Bauer J, Djamshidian A, Weissert R, Wallstroem E et al (2001) Distribution of a calcium channel subunit in dystrophic axons in multiple sclerosis and experimental autoimmune encephalomyelitis. Brain 124(6):1114\u20131124","journal-title":"Brain"},{"issue":"1","key":"5542_CR252","doi-asserted-by":"publisher","first-page":"4071","DOI":"10.1038\/s41467-020-17871-5","volume":"11","author":"KE Carlstr\u00f6m","year":"2020","unstructured":"Carlstr\u00f6m KE, Zhu K, Ewing E, Krabbendam IE, Harris RA, Falc\u00e3o AM et al (2020) Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis. Nat Commun 11(1):4071","journal-title":"Nat Commun"},{"key":"5542_CR253","doi-asserted-by":"crossref","unstructured":"Mao P, Reddy PH (2010) Is multiple sclerosis a mitochondrial disease? Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. 1802(1):66\u201379","DOI":"10.1016\/j.bbadis.2009.07.002"},{"issue":"8","key":"5542_CR254","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1080\/15592294.2020.1735075","volume":"15","author":"NK Singhal","year":"2020","unstructured":"Singhal NK, Sternbach S, Fleming S, Alkhayer K, Shelestak J, Popescu D et al (2020) Betaine restores epigenetic control and supports neuronal mitochondria in the cuprizone mouse model of multiple sclerosis. Epigenetics 15(8):871\u2013886","journal-title":"Epigenetics"},{"issue":"1","key":"5542_CR255","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s12974-016-0788-z","volume":"14","author":"Y Haile","year":"2017","unstructured":"Haile Y, Deng X, Ortiz-Sandoval C, Tahbaz N, Janowicz A, Lu J-Q et al (2017) Rab32 connects ER stress to mitochondrial defects in multiple sclerosis. J Neuroinflamm 14(1):19","journal-title":"J Neuroinflamm"},{"issue":"12","key":"5542_CR256","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.1002\/eji.201948223","volume":"49","author":"S De Biasi","year":"2019","unstructured":"De Biasi S, Simone AM, Bianchini E, Lo Tartaro D, Pecorini S, Nasi M et al (2019) Mitochondrial functionality and metabolism in T cells from progressive multiple sclerosis patients. Eur J Immunol 49(12):2204\u20132221","journal-title":"Eur J Immunol"},{"key":"5542_CR257","doi-asserted-by":"crossref","unstructured":"Mao P, Manczak M, Shirendeb UP, Reddy PH (2013) MitoQ, a mitochondria-targeted antioxidant, delays disease progression and alleviates pathogenesis in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. 1832(12):2322\u20132331","DOI":"10.1016\/j.bbadis.2013.09.005"},{"key":"5542_CR258","doi-asserted-by":"publisher","first-page":"624746","DOI":"10.3389\/fimmu.2021.624746","volume":"12","author":"N Luque-Campos","year":"2021","unstructured":"Luque-Campos N, Bustamante-Barrientos FA, Pradenas C, Garc\u00eda C, Araya MJ, Bohaud C et al (2021) The macrophage response is driven by mesenchymal stem cell-mediated metabolic reprogramming. Front Immunol 12:624746","journal-title":"Front Immunol"},{"key":"5542_CR259","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s00401-020-02179-x","volume":"140","author":"S Licht-Mayer","year":"2020","unstructured":"Licht-Mayer S, Campbell GR, Canizares M, Mehta AR, Gane AB, McGill K et al (2020) Enhanced axonal response of mitochondria to demyelination offers neuroprotection: implications for multiple sclerosis. Acta Neuropathol 140:143\u2013167","journal-title":"Acta Neuropathol"},{"key":"5542_CR260","doi-asserted-by":"publisher","first-page":"2385","DOI":"10.1007\/s11064-013-1151-8","volume":"38","author":"S Li","year":"2013","unstructured":"Li S, Clements R, Sulak M, Gregory R, Freeman E, McDonough J (2013) Decreased NAA in gray matter is correlated with decreased availability of acetate in white matter in postmortem multiple sclerosis cortex. Neurochem Res 38:2385\u20132396","journal-title":"Neurochem Res"},{"issue":"2","key":"5542_CR261","first-page":"37","volume":"8","author":"RM Barcelos IPd, Troxell","year":"2019","unstructured":"Barcelos IPd, Troxell RM, Graves JS (2019) Mitochondrial dysfunction and multiple sclerosis. Biology (Basel) 8(2):37","journal-title":"Biology (Basel)"},{"issue":"3","key":"5542_CR262","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1002\/ana.20736","volume":"59","author":"R Dutta","year":"2006","unstructured":"Dutta R, McDonough J, Yin X, Peterson J, Chang A, Torres T et al (2006) Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients. Ann Neurol 59(3):478\u2013489","journal-title":"Ann Neurol"},{"issue":"7","key":"5542_CR263","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1002\/1873-3468.13013","volume":"592","author":"G Campbell","year":"2018","unstructured":"Campbell G, Mahad DJ (2018) Mitochondrial dysfunction and axon degeneration in progressive multiple sclerosis. FEBS Lett 592(7):1113\u20131121","journal-title":"FEBS Lett"},{"issue":"1","key":"5542_CR264","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s12974-019-1526-0","volume":"16","author":"M Castellazzi","year":"2019","unstructured":"Castellazzi M, Patergnani S, Donadio M, Giorgi C, Bonora M, Fainardi E et al (2019) Correlation between auto\/mitophagic processes and magnetic resonance imaging activity in multiple sclerosis patients. J Neuroinflammation 16(1):131","journal-title":"J Neuroinflammation"},{"issue":"4","key":"5542_CR265","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1042\/BST20170501","volume":"46","author":"R Macdonald","year":"2018","unstructured":"Macdonald R, Barnes K, Hastings C, Mortiboys H (2018) Mitochondrial abnormalities in Parkinson\u2019s disease and Alzheimer\u2019s disease: can mitochondria be targeted therapeutically? Biochem Soc Trans 46(4):891\u2013909","journal-title":"Biochem Soc Trans"},{"issue":"1","key":"5542_CR266","first-page":"8837893","volume":"2020","author":"Q Jiang","year":"2020","unstructured":"Jiang Q, Yin J, Chen J, Ma X, Wu M, Liu G et al (2020) Mitochondria-targeted antioxidants: a step towards disease treatment. Oxidative Med Cell Longev 2020(1):8837893","journal-title":"Oxidative Med Cell Longev"},{"key":"5542_CR267","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.mcn.2019.03.001","volume":"96","author":"DM Oliver","year":"2019","unstructured":"Oliver DM, Reddy PH (2019) Small molecules as therapeutic drugs for Alzheimer\u2019s disease. Mol Cell Neurosci 96:47\u201362","journal-title":"Mol Cell Neurosci"},{"issue":"44","key":"5542_CR268","doi-asserted-by":"publisher","first-page":"15703","DOI":"10.1523\/JNEUROSCI.0552-11.2011","volume":"31","author":"MJ McManus","year":"2011","unstructured":"McManus MJ, Murphy MP, Franklin JL (2011) The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer\u2019s disease. J Neurosci 31(44):15703\u201315715","journal-title":"J Neurosci"},{"key":"5542_CR269","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.freeradbiomed.2014.02.019","volume":"70","author":"E Miquel","year":"2014","unstructured":"Miquel E, Cassina A, Mart\u00ednez-Palma L, Souza JM, Bolatto C, Rodr\u00edguez-Bottero S et al (2014) Neuroprotective effects of the mitochondria-targeted antioxidant MitoQ in a model of inherited amyotrophic lateral sclerosis. Free Radic Biol Med 70:204\u2013213","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"5542_CR270","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1007\/s12325-015-0274-5","volume":"33","author":"A Petrov","year":"2016","unstructured":"Petrov A, Perekhvatova N, Skulachev M, Stein L, Ousler G (2016) SkQ1 ophthalmic solution for dry eye treatment: results of a phase 2 safety and efficacy clinical study in the environment and during challenge in the controlled adverse environment model. Adv therapy 33(1):96\u2013115","journal-title":"Adv therapy"},{"issue":"12","key":"5542_CR271","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1134\/S0006297917120100","volume":"82","author":"V Pavshintsev","year":"2017","unstructured":"Pavshintsev V, Podshivalova L, Frolova O, Belopolskaya M, Averina O, Kushnir E et al (2017) Effects of mitochondrial antioxidant SkQ1 on biochemical and behavioral parameters in a Parkinsonism model in mice. Biochem (Moscow) 82(12):1513\u20131520","journal-title":"Biochem (Moscow)"},{"issue":"11","key":"5542_CR272","doi-asserted-by":"publisher","first-page":"2713","DOI":"10.18632\/aging.101054","volume":"8","author":"NA Stefanova","year":"2016","unstructured":"Stefanova NA, Muraleva NA, Maksimova KY, Rudnitskaya EA, Kiseleva E, Telegina DV et al (2016) An antioxidant specifically targeting mitochondria delays progression of Alzheimer\u2019s disease-like pathology. Aging 8(11):2713","journal-title":"Aging"},{"issue":"6","key":"5542_CR273","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/j.cmet.2014.09.018","volume":"20","author":"M Foretz","year":"2014","unstructured":"Foretz M, Guigas B, Bertrand L, Pollak M, Viollet B (2014) Metformin: from mechanisms of action to therapies. Cell Metabol 20(6):953\u2013966","journal-title":"Cell Metabol"},{"issue":"1","key":"5542_CR274","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s12031-007-9002-1","volume":"34","author":"M-Y El-Mir","year":"2008","unstructured":"El-Mir M-Y, Detaille D, R-Villanueva G, Delgado-Esteban M, Guigas B, Attia S et al (2008) Neuroprotective role of antidiabetic drug metformin against apoptotic cell death in primary cortical neurons. J Mol Neurosci 34(1):77\u201387","journal-title":"J Mol Neurosci"},{"issue":"2","key":"5542_CR275","doi-asserted-by":"publisher","first-page":"501","DOI":"10.3233\/JAD-150493","volume":"51","author":"JA Luchsinger","year":"2016","unstructured":"Luchsinger JA, Perez T, Chang H, Mehta P, Steffener J, Pradabhan G et al (2016) Metformin in amnestic mild cognitive impairment: results of a pilot randomized placebo controlled clinical trial. J Alzheimer\u2019s Disease 51(2):501\u2013514","journal-title":"J Alzheimer\u2019s Disease"},{"key":"5542_CR276","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.neuropharm.2013.08.005","volume":"76","author":"PL McClean","year":"2014","unstructured":"McClean PL, H\u00f6lscher C (2014) Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP\/PS1 mice, a model of Alzheimer\u2019s disease. Neuropharmacology 76:57\u201367","journal-title":"Neuropharmacology"},{"issue":"3","key":"5542_CR277","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s10787-017-0331-6","volume":"25","author":"GA Badawi","year":"2017","unstructured":"Badawi GA, Abd El Fattah MA, Zaki HF, El Sayed MI (2017) Sitagliptin and liraglutide reversed nigrostriatal degeneration of rodent brain in rotenone-induced Parkinson\u2019s disease. Inflammopharmacology 25(3):369\u2013382","journal-title":"Inflammopharmacology"},{"key":"5542_CR278","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.neuroscience.2015.06.054","volume":"303","author":"W Liu","year":"2015","unstructured":"Liu W, Jalewa J, Sharma M, Li G, Li L, H\u00f6lscher C (2015) Neuroprotective effects of lixisenatide and liraglutide in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine mouse model of Parkinson\u2019s disease. Neuroscience 303:42\u201350","journal-title":"Neuroscience"},{"key":"5542_CR279","doi-asserted-by":"publisher","first-page":"198350","DOI":"10.3389\/fnagi.2016.00108","volume":"8","author":"M Gejl","year":"2016","unstructured":"Gejl M, Gjedde A, Egefjord L, M\u00f8ller A, Hansen SB, Vang K et al (2016) In Alzheimer\u2019s disease, 6-month treatment with GLP-1 analog prevents decline of brain glucose metabolism: randomized, placebo-controlled, double-blind clinical trial. Front Aging Neurosci 8:198350","journal-title":"Front Aging Neurosci"},{"issue":"1","key":"5542_CR280","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1093\/brain\/awac309","volume":"146","author":"M Leclerc","year":"2023","unstructured":"Leclerc M, Bourassa P, Tremblay C, Caron V, Sug\u00e8re C, Emond V et al (2023) Cerebrovascular insulin receptors are defective in Alzheimer\u2019s disease. Brain 146(1):75\u201390","journal-title":"Brain"},{"issue":"8","key":"5542_CR281","doi-asserted-by":"publisher","first-page":"eade8137","DOI":"10.1126\/sciadv.ade8137","volume":"9","author":"M Baghdadi","year":"2023","unstructured":"Baghdadi M, Nespital T, Mesaros A, Buschbaum S, Withers DJ, Gr\u00f6nke S et al (2023) Reduced insulin signaling in neurons induces sex-specific health benefits. Sci Adv 9(8):eade8137","journal-title":"Sci Adv"},{"issue":"1","key":"5542_CR282","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/sj.npp.1301193","volume":"32","author":"C Benedict","year":"2007","unstructured":"Benedict C, Hallschmid M, Schmitz K, Schultes B, Ratter F, Fehm HL et al (2007) Intranasal insulin improves memory in humans: superiority of insulin aspart. Neuropsychopharmacology 32(1):239\u2013243","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"5542_CR283","doi-asserted-by":"publisher","first-page":"897","DOI":"10.3233\/JAD-141791","volume":"44","author":"A Claxton","year":"2015","unstructured":"Claxton A, Baker LD, Hanson A, Trittschuh EH, Cholerton B, Morgan A et al (2015) Long-acting intranasal insulin detemir improves cognition for adults with mild cognitive impairment or early-stage Alzheimer\u2019s disease dementia. J Alzheimer\u2019s Disease 44(3):897\u2013906","journal-title":"J Alzheimer\u2019s Disease"},{"issue":"6","key":"5542_CR284","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1212\/01.WNL.0000265401.62434.36","volume":"70","author":"MA Reger","year":"2008","unstructured":"Reger MA, Watson GS, Green PS, Wilkinson CW, Baker LD, Cholerton B et al (2008) Intranasal insulin improves cognition and modulates \u03b2-amyloid in early AD. Neurology 70(6):440\u2013448","journal-title":"Neurology"},{"issue":"4","key":"5542_CR285","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.3233\/JAD-161256","volume":"57","author":"S Craft","year":"2017","unstructured":"Craft S, Claxton A, Baker LD, Hanson AJ, Cholerton B, Trittschuh EH et al (2017) Effects of regular and long-acting insulin on cognition and Alzheimer\u2019s disease biomarkers: a pilot clinical trial. J Alzheimer\u2019s Disease 57(4):1325\u20131334","journal-title":"J Alzheimer\u2019s Disease"},{"issue":"3","key":"5542_CR286","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1530\/JOE-17-0263","volume":"234","author":"P Millar","year":"2017","unstructured":"Millar P, Pathak N, Parthsarathy V, Bjourson AJ, O\u2019Kane M, Pathak V et al (2017) Metabolic and neuroprotective effects of dapagliflozin and liraglutide in diabetic mice. J Endocrinol 234(3):255\u2013267","journal-title":"J Endocrinol"},{"issue":"11","key":"5542_CR287","doi-asserted-by":"publisher","first-page":"2036","DOI":"10.2337\/dc15-2688","volume":"39","author":"G Daniele","year":"2016","unstructured":"Daniele G, Xiong J, Solis-Herrera C, Merovci A, Eldor R, Tripathy D et al (2016) Dapagliflozin enhances fat oxidation and ketone production in patients with type 2 diabetes. Diabetes Care 39(11):2036\u20132041","journal-title":"Diabetes Care"},{"key":"5542_CR288","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.taap.2017.08.005","volume":"333","author":"P Sa-Nguanmoo","year":"2017","unstructured":"Sa-Nguanmoo P, Tanajak P, Kerdphoo S, Jaiwongkam T, Pratchayasakul W, Chattipakorn N et al (2017) SGLT2-inhibitor and DPP-4 inhibitor improve brain function via attenuating mitochondrial dysfunction, insulin resistance, inflammation, and apoptosis in HFD-induced obese rats. Toxicol Appl Pharmcol 333:43\u201350","journal-title":"Toxicol Appl Pharmcol"},{"key":"5542_CR289","doi-asserted-by":"publisher","first-page":"658362","DOI":"10.3389\/fphar.2021.658362","volume":"12","author":"Z Zhang","year":"2021","unstructured":"Zhang Z, Zhang X, Meng L, Gong M, Li J, Shi W et al (2021) Pioglitazone inhibits diabetes-induced atrial mitochondrial oxidative stress and improves mitochondrial biogenesis, dynamics, and function through the PPAR-\u03b3\/PGC-1\u03b1 signaling pathway. Front Pharmacol 12:658362","journal-title":"Front Pharmacol"},{"issue":"02\/03","key":"5542_CR290","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1055\/a-1085-2542","volume":"70","author":"E Seydi","year":"2020","unstructured":"Seydi E, Servati T, Samiei F, Naserzadeh P, Pourahmad J (2020) Toxicity of pioglitazone on mitochondria isolated from brain and heart: An analysis for probable drug-induced neurotoxicity and cardiotoxicity. Drug Res 70(02\/03):112\u2013118","journal-title":"Drug Res"},{"issue":"2","key":"5542_CR291","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1002\/ana.24439","volume":"78","author":"MT Heneka","year":"2015","unstructured":"Heneka MT, Fink A, Doblhammer G (2015) Effect of pioglitazone medication on the incidence of dementia. Ann Neurol 78(2):284\u2013294","journal-title":"Ann Neurol"},{"issue":"17","key":"5542_CR292","doi-asserted-by":"publisher","first-page":"e1799","DOI":"10.1212\/WNL.0000000000207069","volume":"100","author":"J Ha","year":"2023","unstructured":"Ha J, Choi D-W, Kim KJ, Kim KY, Nam CM, Kim E (2023) Pioglitazone use and reduced risk of dementia in patients with diabetes mellitus with a history of ischemic stroke. Neurology 100(17):e1799\u2013e811","journal-title":"Neurology"},{"key":"5542_CR293","doi-asserted-by":"crossref","unstructured":"Walker JA, Nelleman L, Henderson ST, Morimoto B (2020) Clinical development of tricaprilin, a ketogenic drug for Alzheimer\u2019s disease: Human\/Human trials: Other. Alzheimer\u2019s & Dementia. ;16:e038787","DOI":"10.1002\/alz.038787"},{"key":"5542_CR294","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.ejpb.2022.11.022","volume":"182","author":"Z Li","year":"2023","unstructured":"Li Z, Ramirez G, Tang R, Paul CKX, Nair M, Henderson S et al (2023) Modeling digestion, absorption, and ketogenesis after administration of tricaprilin formulations to humans. Eur J Pharm Biopharm 182:41\u201352","journal-title":"Eur J Pharm Biopharm"},{"issue":"2","key":"5542_CR295","doi-asserted-by":"publisher","first-page":"547","DOI":"10.3233\/JAD-191302","volume":"75","author":"ST Henderson","year":"2020","unstructured":"Henderson ST, Morimoto BH, Cummings JL, Farlow MR, Walker J (2020) A placebo-controlled, parallel-group, randomized clinical trial of AC-1204 in mild-to-moderate Alzheimer\u2019s disease. J Alzheimer\u2019s Disease 75(2):547\u2013557","journal-title":"J Alzheimer\u2019s Disease"},{"issue":"suppl1","key":"5542_CR296","doi-asserted-by":"publisher","first-page":"P1857","DOI":"10.1093\/eurheartj\/eht308.P1857","volume":"34","author":"M Kobara","year":"2013","unstructured":"Kobara M, Shiraishi T, Noda K, Ohhigashi M, Toba H, Nakata T (2013) Eicosapentaenoic acid mediates mitochondrial fatty acid composition and fusion protein OPA-1 in associated with preservation of oxidative phosphorylation after myocardial infarction. Eur Heart J 34(suppl1):P1857","journal-title":"Eur Heart J"},{"key":"5542_CR297","doi-asserted-by":"crossref","unstructured":"Boston PF, Bennett A, Horrobin DF, Bennett CN (2004) Ethyl-EPA in Alzheimer\u2019s disease\u2014a pilot study. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA). 71(5):341\u2013346","DOI":"10.1016\/j.plefa.2004.07.001"},{"key":"5542_CR298","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.tifs.2017.06.019","volume":"67","author":"MR de Oliveira","year":"2017","unstructured":"de Oliveira MR, Nabavi SF, Nabavi SM, Jardim FR (2017) Omega-3 polyunsaturated fatty acids and mitochondria, back to the future. Trends Food Sci Technol 67:76\u201392","journal-title":"Trends Food Sci Technol"},{"issue":"3","key":"5542_CR299","doi-asserted-by":"publisher","first-page":"823","DOI":"10.3233\/JAD-132042","volume":"42","author":"Y Freund-Levi","year":"2014","unstructured":"Freund-Levi Y, Vedin I, Hjorth E, Basun H, Fax\u00e9n Irving G, Schultzberg M et al (2014) Effects of supplementation with omega-3 fatty acids on oxidative stress and inflammation in patients with Alzheimer\u2019s disease: the OmegAD study. J Alzheimer\u2019s Disease 42(3):823\u2013831","journal-title":"J Alzheimer\u2019s Disease"},{"issue":"17","key":"5542_CR300","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1001\/jama.2010.1510","volume":"304","author":"JF Quinn","year":"2010","unstructured":"Quinn JF, Raman R, Thomas RG, Yurko-Mauro K, Nelson EB, Van Dyck C et al (2010) Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial. JAMA 304(17):1903\u20131911","journal-title":"JAMA"},{"issue":"3","key":"5542_CR301","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.cmet.2022.02.001","volume":"34","author":"B Brakedal","year":"2022","unstructured":"Brakedal B, D\u00f6lle C, Riemer F, Ma Y, Nido GS, Skeie GO et al (2022) The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson\u2019s disease. Cell Metabol 34(3):396\u2013407 e6","journal-title":"Cell Metabol"},{"key":"5542_CR302","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.parkreldis.2021.11.022","volume":"94","author":"JL Schultz","year":"2022","unstructured":"Schultz JL, Brinker AN, Xu J, Ernst SE, Tayyari F, Rauckhorst AJ et al (2022) A pilot to assess target engagement of terazosin in Parkinson\u2019s disease. Parkinsonism Relat Disord 94:79\u201383","journal-title":"Parkinsonism Relat Disord"},{"issue":"8","key":"5542_CR303","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1089\/ars.2020.8134","volume":"34","author":"G Plascencia-Villa","year":"2021","unstructured":"Plascencia-Villa G, Perry G (2021) Preventive and therapeutic strategies in Alzheimer\u2019s disease: focus on oxidative stress, redox metals, and ferroptosis. Antioxid Redox Signal 34(8):591\u2013610","journal-title":"Antioxid Redox Signal"},{"issue":"22","key":"5542_CR304","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1056\/NEJMoa2209254","volume":"387","author":"D Devos","year":"2022","unstructured":"Devos D, Labreuche J, Rascol O, Corvol J-C, Duhamel A, Guyon Delannoy P et al (2022) Trial of deferiprone in Parkinson\u2019s disease. N Engl J Med 387(22):2045\u20132055","journal-title":"N Engl J Med"},{"issue":"1","key":"5542_CR305","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s13578-022-00805-7","volume":"12","author":"Z Liu","year":"2022","unstructured":"Liu Z, Sun Y, Qi Z, Cao L, Ding S (2022) Mitochondrial transfer\/transplantation: an emerging therapeutic approach for multiple diseases. Cell bioscience 12(1):66","journal-title":"Cell bioscience"},{"issue":"7613","key":"5542_CR306","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/nature18928","volume":"535","author":"K Hayakawa","year":"2016","unstructured":"Hayakawa K, Esposito E, Wang X, Terasaki Y, Liu Y, Xing C et al (2016) Transfer of mitochondria from astrocytes to neurons after stroke. Nature 535(7613):551\u2013555","journal-title":"Nature"},{"issue":"7","key":"5542_CR307","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.7150\/thno.29400","volume":"9","author":"H Li","year":"2019","unstructured":"Li H, Wang C, He T, Zhao T, Chen Y-y, Shen Y-l et al (2019) Mitochondrial transfer from bone marrow mesenchymal stem cells to motor neurons in spinal cord injury rats via gap junction. Theranostics 9(7):2017","journal-title":"Theranostics"},{"issue":"4","key":"5542_CR308","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1177\/0271678X20928147","volume":"41","author":"N Tseng","year":"2021","unstructured":"Tseng N, Lambie SC, Huynh CQ, Sanford B, Patel M, Herson PS et al (2021) Mitochondrial transfer from mesenchymal stem cells improves neuronal metabolism after oxidant injury in vitro: The role of Miro1. J Cereb Blood Flow Metabolism 41(4):761\u2013770","journal-title":"J Cereb Blood Flow Metabolism"},{"key":"5542_CR309","doi-asserted-by":"crossref","unstructured":"Peruzzotti-Jametti L, Bernstock JD, Manferrari G, Rogall R, Fernandez-Vizarra E, Williamson JC et al Neural stem cells traffic functional mitochondria via extracellular vesicles to correct mitochondrial dysfunction in target cells. bioRxiv. 2020:2020.01. 29.923441.","DOI":"10.1101\/2020.01.29.923441"},{"key":"5542_CR310","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40478-018-0644-8","volume":"6","author":"N Boukelmoune","year":"2018","unstructured":"Boukelmoune N, Chiu GS, Kavelaars A, Heijnen CJ (2018) Mitochondrial transfer from mesenchymal stem cells to neural stem cells protects against the neurotoxic effects of cisplatin. Acta Neuropathol Commun 6:1\u201313","journal-title":"Acta Neuropathol Commun"},{"issue":"1","key":"5542_CR311","first-page":"7610414","volume":"2017","author":"A Caicedo","year":"2017","unstructured":"Caicedo A, Aponte PM, Cabrera F, Hidalgo C, Khoury M (2017) Artificial mitochondria transfer: current challenges, advances, and future applications. Stem cells Int 2017(1):7610414","journal-title":"Stem cells Int"},{"key":"5542_CR312","doi-asserted-by":"publisher","first-page":"320","DOI":"10.3389\/fncel.2018.00320","volume":"12","author":"A Dong","year":"2018","unstructured":"Dong A, Liu S, Li Y (2018) Gap junctions in the nervous system: probing functional connections using new imaging approaches. Front Cell Neurosci 12:320","journal-title":"Front Cell Neurosci"},{"issue":"36","key":"5542_CR313","doi-asserted-by":"publisher","first-page":"7001","DOI":"10.1523\/JNEUROSCI.2222-21.2022","volume":"42","author":"R Tashiro","year":"2022","unstructured":"Tashiro R, Bautista-Garrido J, Ozaki D, Sun G, Obertas L, Mobley AS et al (2022) Transplantation of astrocytic mitochondria modulates neuronal antioxidant defense and neuroplasticity and promotes functional recovery after intracerebral hemorrhage. J Neurosci 42(36):7001\u20137014","journal-title":"J Neurosci"},{"key":"5542_CR314","doi-asserted-by":"publisher","first-page":"135940","DOI":"10.1016\/j.neulet.2021.135940","volume":"756","author":"X Li","year":"2021","unstructured":"Li X, Li Y, Zhang Z, Bian Q, Gao Z, Zhang S (2021) Mild hypothermia facilitates mitochondrial transfer from astrocytes to injured neurons during oxygen-glucose deprivation\/reoxygenation. Neurosci Lett 756:135940","journal-title":"Neurosci Lett"},{"key":"5542_CR315","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.jconrel.2022.01.025","volume":"343","author":"T Huang","year":"2022","unstructured":"Huang T, Zhang T, Gao J (2022) Targeted mitochondrial delivery: a therapeutic new era for disease treatment. J Controlled Release 343:89\u2013106","journal-title":"J Controlled Release"},{"key":"5542_CR316","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.trsl.2015.12.003","volume":"170","author":"J-C Chang","year":"2016","unstructured":"Chang J-C, Wu S-L, Liu K-H, Chen Y-H, Chuang C-S, Cheng F-C et al (2016) Allogeneic\/xenogeneic transplantation of peptide-labeled mitochondria in Parkinson\u2019s disease: restoration of mitochondria functions and attenuation of 6-hydroxydopamine\u2013induced neurotoxicity. Translational Res 170:40\u201356 e3","journal-title":"Translational Res"},{"issue":"1","key":"5542_CR317","doi-asserted-by":"publisher","first-page":"10597","DOI":"10.1038\/s41598-021-90094-w","volume":"11","author":"J-C Chang","year":"2021","unstructured":"Chang J-C, Chao Y-C, Chang H-S, Wu Y-L, Chang H-J, Lin Y-S et al (2021) Intranasal delivery of mitochondria for treatment of Parkinson\u2019s Disease model rats lesioned with 6-hydroxydopamine. Sci Rep 11(1):10597","journal-title":"Sci Rep"},{"key":"5542_CR318","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40035-020-00190-6","volume":"9","author":"X-Y Cheng","year":"2020","unstructured":"Cheng X-Y, Biswas S, Li J, Mao C-J, Chechneva O, Chen J et al (2020) Human iPSCs derived astrocytes rescue rotenone-induced mitochondrial dysfunction and dopaminergic neurodegeneration in vitro by donating functional mitochondria. Translational Neurodegeneration 9:1\u201314","journal-title":"Translational Neurodegeneration"},{"issue":"2","key":"5542_CR319","doi-asserted-by":"publisher","first-page":"587","DOI":"10.3233\/JAD-190853","volume":"72","author":"K Nitzan","year":"2019","unstructured":"Nitzan K, Benhamron S, Valitsky M, Kesner EE, Lichtenstein M, Ben-Zvi A et al (2019) Mitochondrial transfer ameliorates cognitive deficits, neuronal loss, and gliosis in Alzheimer\u2019s disease mice. J Alzheimer\u2019s Disease 72(2):587\u2013604","journal-title":"J Alzheimer\u2019s Disease"},{"issue":"4","key":"5542_CR320","doi-asserted-by":"publisher","first-page":"e3001166","DOI":"10.1371\/journal.pbio.3001166","volume":"19","author":"L Peruzzotti-Jametti","year":"2021","unstructured":"Peruzzotti-Jametti L, Bernstock JD, Willis CM, Manferrari G, Rogall R, Fernandez-Vizarra E et al (2021) Neural stem cells traffic functional mitochondria via extracellular vesicles. PLoS Biol 19(4):e3001166","journal-title":"PLoS Biol"},{"key":"5542_CR321","doi-asserted-by":"crossref","unstructured":"Riou A, Broeglin A, Grimm A (2024) Mitochondrial Transplantation in Brain Disorders: Achievements, Methods, and Challenges. Neuroscience & Biobehavioral Reviews. :105971","DOI":"10.1016\/j.neubiorev.2024.105971"},{"key":"5542_CR322","doi-asserted-by":"crossref","unstructured":"Walker M, Levitt MR, Federico EM, Miralles FJ, Levy SH, Lynne Prijoles K et al (2024) Autologous mitochondrial transplant for acute cerebral ischemia: Phase 1 trial results and review. J Cereb Blood Flow Metabolism. :0271678X241305230","DOI":"10.1177\/0271678X241305230"},{"issue":"1","key":"5542_CR323","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s13287-024-03771-8","volume":"15","author":"DF Bodenstein","year":"2024","unstructured":"Bodenstein DF, Siebiger G, Zhao Y, Clasky AJ, Mukkala AN, Beroncal EL et al (2024) Bridging the gap between in vitro and in vivo models: a way forward to clinical translation of mitochondrial transplantation in acute disease states. Stem Cell Res Ther 15(1):157","journal-title":"Stem Cell Res Ther"},{"key":"5542_CR324","doi-asserted-by":"crossref","unstructured":"Wei R, Chen Y, Yang Q, Wang T, He Y, Yin N et al (2025) Nanoenzyme-Anchored Mitofactories Boost Mitochondrial Transplantation to Restore Locomotor Function after Paralysis Following Spinal Cord Injury. ACS Nano","DOI":"10.1021\/acsnano.4c12557"},{"issue":"1","key":"5542_CR325","doi-asserted-by":"publisher","first-page":"1006636","DOI":"10.1155\/2021\/1006636","volume":"2021","author":"Q Xie","year":"2021","unstructured":"Xie Q, Zeng J, Zheng Y, Li T, Ren J, Chen K et al (2021) Mitochondrial transplantation attenuates cerebral ischemia-reperfusion injury: possible involvement of mitochondrial component separation. Oxidative Med Cell Longev 2021(1):1006636","journal-title":"Oxidative Med Cell Longev"},{"key":"5542_CR326","doi-asserted-by":"crossref","unstructured":"Smith RA, Porteous CM, Gane AM, Murphy MP (2003) Delivery of bioactive molecules to mitochondria in vivo. Proceedings of the National Academy of Sciences. ;100(9):5407-12","DOI":"10.1073\/pnas.0931245100"},{"issue":"8","key":"5542_CR327","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1089\/ars.2014.5952","volume":"22","author":"N Apostolova","year":"2015","unstructured":"Apostolova N, Victor VM (2015) Molecular strategies for targeting antioxidants to mitochondria: therapeutic implications. Antioxid Redox Signal 22(8):686\u2013729","journal-title":"Antioxid Redox Signal"},{"issue":"7","key":"5542_CR328","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.biopha.2005.06.005","volume":"59","author":"J Tucker","year":"2005","unstructured":"Tucker J, Townsend D (2005) Alpha-tocopherol: roles in prevention and therapy of human disease. Biomed Pharmacother 59(7):380\u2013387","journal-title":"Biomed Pharmacother"},{"key":"5542_CR329","doi-asserted-by":"publisher","first-page":"206","DOI":"10.3389\/fphar.2015.00206","volume":"6","author":"A Kumar","year":"2015","unstructured":"Kumar A, Singh A (2015) A review on mitochondrial restorative mechanism of antioxidants in Alzheimer\u2019s disease and other neurological conditions. Front Pharmacol 6:206","journal-title":"Front Pharmacol"},{"issue":"36","key":"5542_CR330","doi-asserted-by":"publisher","first-page":"37575","DOI":"10.1074\/jbc.M404003200","volume":"279","author":"A Dhanasekaran","year":"2004","unstructured":"Dhanasekaran A, Kotamraju S, Kalivendi SV, Matsunaga T, Shang T, Keszler A et al (2004) Supplementation of endothelial cells with mitochondria-targeted antioxidants inhibit peroxide-induced mitochondrial iron uptake, oxidative damage, and apoptosis. J Biol Chem 279(36):37575\u201337587","journal-title":"J Biol Chem"},{"issue":"3","key":"5542_CR331","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1046\/j.1432-1327.1999.00543.x","volume":"263","author":"RA Smith","year":"1999","unstructured":"Smith RA, Porteous CM, Coulter CV, Murphy MP (1999) Selective targeting of an antioxidant to mitochondria. Eur J Biochem 263(3):709\u2013716","journal-title":"Eur J Biochem"},{"issue":"13","key":"5542_CR332","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1096\/fj.03-0240fje","volume":"17","author":"ML Jauslin","year":"2003","unstructured":"Jauslin ML, Meier T, Smith RAJ, Murphy PM (2003) Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants. FASEB J 17(13):1\u201310","journal-title":"FASEB J"},{"issue":"7","key":"5542_CR333","doi-asserted-by":"publisher","first-page":"4588","DOI":"10.1074\/jbc.M009093200","volume":"276","author":"GF Kelso","year":"2001","unstructured":"Kelso GF, Porteous CM, Coulter CV, Hughes G, Porteous WK, Ledgerwood EC et al (2001) Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties. J Biol Chem 276(7):4588\u20134596","journal-title":"J Biol Chem"},{"issue":"s2","key":"5542_CR334","doi-asserted-by":"publisher","first-page":"S609","DOI":"10.3233\/JAD-2010-100564","volume":"20","author":"M Manczak","year":"2010","unstructured":"Manczak M, Mao P, Calkins MJ, Cornea A, Reddy AP, Murphy MP et al (2010) Mitochondria-targeted antioxidants protect against amyloid-\u03b2 toxicity in Alzheimer\u2019s disease neurons. J Alzheimer\u2019s Disease 20(s2):S609\u2013S31","journal-title":"J Alzheimer\u2019s Disease"},{"key":"5542_CR335","doi-asserted-by":"crossref","unstructured":"Xi Y, Feng D, Tao K, Wang R, Shi Y, Qin H et al (2018) MitoQ protects dopaminergic neurons in a 6-OHDA induced PD model by enhancing Mfn2-dependent mitochondrial fusion via activation of PGC-1\u03b1. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. 1864(9):2859\u20132870","DOI":"10.1016\/j.bbadis.2018.05.018"},{"issue":"Special","key":"5542_CR336","doi-asserted-by":"publisher","first-page":"548","DOI":"10.3177\/jnsv.38.Special_548","volume":"38","author":"L Ernster","year":"1992","unstructured":"Ernster L, Forsmark P, Nordenbrand K (1992) The mode of action of lipid-soluble antioxidants in biological membranes. Relationship between the effects of ubiquinol and vitamin E as inhibitors of lipid peroxidation in submitochondrial particles. J Nutri Sci Vitaminol 38(Special):548\u2013551","journal-title":"J Nutri Sci Vitaminol"},{"issue":"12","key":"5542_CR337","doi-asserted-by":"publisher","first-page":"4766","DOI":"10.1096\/fj.15-275404","volume":"29","author":"AO Oyewole","year":"2015","unstructured":"Oyewole AO, Birch-Machin MA (2015) Mitochondria\u2010targeted antioxidants. FASEB J 29(12):4766\u20134771","journal-title":"FASEB J"},{"key":"5542_CR338","doi-asserted-by":"crossref","unstructured":"Kagan VE, Serbinova EA, Stoyanovsky D, Khwaja S, Packer L (1994) [33] Assay of ubiquinones and ubiquinols as antioxidants. Methods in enzymology. 234: Elsevier; pp. 343\u2009\u2013\u200954","DOI":"10.1016\/0076-6879(94)34104-4"},{"issue":"1","key":"5542_CR339","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1073\/pnas.90.1.45","volume":"90","author":"KU Ingold","year":"1993","unstructured":"Ingold KU, Bowry VW, Stocker R, Walling C (1993) Autoxidation of lipids and antioxidation by alpha-tocopherol and ubiquinol in homogeneous solution and in aqueous dispersions of lipids: unrecognized consequences of lipid particle size as exemplified by oxidation of human low density lipoprotein. Proc Natl Acad Sci 90(1):45\u201349","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"5542_CR340","first-page":"174","volume":"1832","author":"ME Solesio","year":"2013","unstructured":"Solesio ME, Prime TA, Logan A, Murphy MP, del Mar Arroyo-Jimenez M, Jord\u00e1n J et al (2013) The mitochondria-targeted anti-oxidant MitoQ reduces aspects of mitochondrial fission in the 6-OHDA cell model of Parkinson\u2019s disease. Biochim et Biophys Acta (BBA)-Molecular Basis Disease 1832(1):174\u2013182","journal-title":"Biochim et Biophys Acta (BBA)-Molecular Basis Disease"},{"issue":"11","key":"5542_CR341","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1016\/j.freeradbiomed.2010.08.028","volume":"49","author":"A Ghosh","year":"2010","unstructured":"Ghosh A, Chandran K, Kalivendi SV, Joseph J, Antholine WE, Hillard CJ et al (2010) Neuroprotection by a mitochondria-targeted drug in a Parkinson\u2019s disease model. Free Radic Biol Med 49(11):1674\u20131684","journal-title":"Free Radic Biol Med"},{"issue":"11","key":"5542_CR342","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1002\/mds.23148","volume":"25","author":"BJ Snow","year":"2010","unstructured":"Snow BJ, Rolfe FL, Lockhart MM, Frampton CM, O\u2019Sullivan JD, Fung V et al (2010) A double-blind, placebo\u2010controlled study to assess the mitochondria\u2010targeted antioxidant MitoQ as a disease\u2010modifying therapy in Parkinson\u2019s disease. Mov Disord 25(11):1670\u20131674","journal-title":"Mov Disord"},{"issue":"23","key":"5542_CR343","doi-asserted-by":"publisher","first-page":"7005","DOI":"10.1113\/JP272491","volume":"594","author":"DD Shill","year":"2016","unstructured":"Shill DD, Southern WM, Willingham TB, Lansford KA, McCully KK, Jenkins NT (2016) Mitochondria-specific antioxidant supplementation does not influence endurance exercise training\u2010induced adaptations in circulating angiogenic cells, skeletal muscle oxidative capacity or maximal oxygen uptake. J Physiol 594(23):7005\u20137014","journal-title":"J Physiol"},{"key":"5542_CR344","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.freeradbiomed.2019.11.021","volume":"146","author":"BR Pinho","year":"2020","unstructured":"Pinho BR, Duarte AI, Canas PM, Moreira PI, Murphy MP, Oliveira JM (2020) The interplay between redox signalling and proteostasis in neurodegeneration: In vivo effects of a mitochondria-targeted antioxidant in Huntington\u2019s disease mice. Free Radic Biol Med 146:372\u2013382","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"5542_CR345","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/0003-9861(91)90442-L","volume":"289","author":"JB Mitchell","year":"1991","unstructured":"Mitchell JB, DeGraff W, Kaufman D, Krishna MC, Samuni A, Finkelstein E et al (1991) Inhibition of oxygen-dependent radiation-induced damage by the nitroxide superoxide dismutase mimic, tempol. Arch Biochem Biophys 289(1):62\u201370","journal-title":"Arch Biochem Biophys"},{"key":"5542_CR346","doi-asserted-by":"publisher","first-page":"110330","DOI":"10.1016\/j.cellsig.2022.110330","volume":"94","author":"R Zhang","year":"2022","unstructured":"Zhang R, Liu C, Yang L, Ji T, Zhang N, Dong X et al (2022) NOX2-derived hydrogen peroxide impedes the AMPK\/Akt-mTOR signaling pathway contributing to cell death in neuronal cells. Cell Signal 94:110330","journal-title":"Cell Signal"},{"issue":"8","key":"5542_CR347","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1080\/10715762.2016.1185519","volume":"50","author":"H Kim","year":"2016","unstructured":"Kim H, Kim SH, Cha H, Kim SR, Lee JH, Park J-W (2016) IDH2 deficiency promotes mitochondrial dysfunction and dopaminergic neurotoxicity: implications for Parkinson\u2019s disease. Free Radic Res 50(8):853\u2013860","journal-title":"Free Radic Res"},{"issue":"1","key":"5542_CR348","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.bbrc.2016.07.071","volume":"478","author":"H Hu","year":"2016","unstructured":"Hu H, Li M (2016) Mitochondria-targeted antioxidant mitotempo protects mitochondrial function against amyloid beta toxicity in primary cultured mouse neurons. Biochem Biophys Res Commun 478(1):174\u2013180","journal-title":"Biochem Biophys Res Commun"},{"issue":"15","key":"5542_CR349","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1093\/hmg\/ddab363","volume":"31","author":"F Du","year":"2022","unstructured":"Du F, Yu Q, Kanaan NM, Yan SS (2022) Mitochondrial oxidative stress contributes to the pathological aggregation and accumulation of tau oligomers in Alzheimer\u2019s disease. Hum Mol Genet 31(15):2498\u20132507","journal-title":"Hum Mol Genet"},{"key":"5542_CR350","doi-asserted-by":"publisher","first-page":"963169","DOI":"10.3389\/fncel.2022.963169","volume":"16","author":"M Junghans","year":"2022","unstructured":"Junghans M, John F, Cihankaya H, Schliebs D, Winklhofer KF, Bader V et al (2022) ROS scavengers decrease \u03b3H2ax spots in motor neuronal nuclei of ALS model mice in vitro. Front Cell Neurosci 16:963169","journal-title":"Front Cell Neurosci"},{"issue":"4","key":"5542_CR351","doi-asserted-by":"publisher","first-page":"573","DOI":"10.3390\/antiox10040573","volume":"10","author":"LJ Shinn","year":"2021","unstructured":"Shinn LJ, Lagalwar S (2021) Treating neurodegenerative disease with antioxidants: Efficacy of the bioactive phenol resveratrol and mitochondrial-targeted MitoQ and SkQ. Antioxidants 10(4):573","journal-title":"Antioxidants"},{"key":"5542_CR352","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1134\/S0006297917120100","volume":"82","author":"V Pavshintsev","year":"2017","unstructured":"Pavshintsev V, Podshivalova L, Frolova O, Belopolskaya M, Averina O, Kushnir E et al (2017) Effects of mitochondrial antioxidant SkQ1 on biochemical and behavioral parameters in a Parkinsonism model in mice. Biochem (Moscow) 82:1513\u20131520","journal-title":"Biochem (Moscow)"},{"issue":"3","key":"5542_CR353","doi-asserted-by":"publisher","first-page":"681","DOI":"10.3233\/JAD-131034","volume":"38","author":"NA Stefanova","year":"2013","unstructured":"Stefanova NA, Muraleva NA, Skulachev VP, Kolosova NG (2013) Alzheimer\u2019s disease-like pathology in senescence-accelerated OXYS rats can be partially retarded with mitochondria-targeted antioxidant SkQ1. J Alzheimer\u2019s disease 38(3):681\u2013694","journal-title":"J Alzheimer\u2019s disease"},{"issue":"2","key":"5542_CR354","doi-asserted-by":"publisher","first-page":"315","DOI":"10.18632\/aging.101174","volume":"9","author":"IG Shabalina","year":"2017","unstructured":"Shabalina IG, Vyssokikh MY, Gibanova N, Csikasz RI, Edgar D, Hallden-Waldemarson A et al (2017) Improved health-span and lifespan in mtDNA mutator mice treated with the mitochondrially targeted antioxidant SkQ1. Aging 9(2):315","journal-title":"Aging"},{"key":"5542_CR355","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1007\/s12325-015-0274-5","volume":"33","author":"A Petrov","year":"2016","unstructured":"Petrov A, Perekhvatova N, Skulachev M, Stein L, Ousler G (2016) SkQ1 ophthalmic solution for dry eye treatment: results of a phase 2 safety and efficacy clinical study in the environment and during challenge in the controlled adverse environment model. Adv therapy 33:96\u2013115","journal-title":"Adv therapy"},{"issue":"2","key":"5542_CR356","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.bbadis.2005.10.007","volume":"1762","author":"SS Sheu","year":"2006","unstructured":"Sheu SS, Nauduri D, Anders MW (2006) Targeting antioxidants to mitochondria: a new therapeutic direction. Biochim Biophys Acta 1762(2):256\u2013265","journal-title":"Biochim Biophys Acta"},{"issue":"12","key":"5542_CR357","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1016\/j.bcp.2005.08.022","volume":"70","author":"K Zhao","year":"2005","unstructured":"Zhao K, Luo G, Giannelli S, Szeto HH (2005) Mitochondria-targeted peptide prevents mitochondrial depolarization and apoptosis induced by tert-butyl hydroperoxide in neuronal cell lines. Biochem Pharmacol 70(12):1796\u20131806","journal-title":"Biochem Pharmacol"},{"issue":"10","key":"5542_CR358","doi-asserted-by":"publisher","first-page":"e820","DOI":"10.1038\/cddis.2013.341","volume":"4","author":"Y Noh","year":"2013","unstructured":"Noh Y, Kim K, Shim M, Choi S, Choi S, Ellisman M et al (2013) Inhibition of oxidative stress by coenzyme Q10 increases mitochondrial mass and improves bioenergetic function in optic nerve head astrocytes. Cell Death Dis 4(10):e820\u2013e","journal-title":"Cell Death Dis"},{"issue":"3","key":"5542_CR359","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/j.nbd.2004.10.021","volume":"18","author":"M Somayajulu","year":"2005","unstructured":"Somayajulu M, McCarthy S, Hung M, Sikorska M, Borowy-Borowski H, Pandey S (2005) Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10. Neurobiol Dis 18(3):618\u2013627","journal-title":"Neurobiol Dis"},{"key":"5542_CR360","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12986-019-0418-8","volume":"16","author":"L Hocum Stone","year":"2019","unstructured":"Hocum Stone L, Chappuis E, Wright C, Kelly RF, McFalls EO (2019) CoQ 10 enhances PGC1\u03b1 and increases expression of mitochondrial antioxidant proteins in chronically ischemic swine myocardium. Nutr Metabolism 16:1\u201310","journal-title":"Nutr Metabolism"},{"issue":"16","key":"5542_CR361","doi-asserted-by":"publisher","first-page":"2606","DOI":"10.1089\/ars.2013.5406","volume":"20","author":"G Tian","year":"2014","unstructured":"Tian G, Sawashita J, Kubo H, Nishio S-y, Hashimoto S, Suzuki N et al (2014) Ubiquinol-10 supplementation activates mitochondria functions to decelerate senescence in senescence-accelerated mice. Antioxid Redox Signal 20(16):2606\u20132620","journal-title":"Antioxid Redox Signal"},{"key":"5542_CR362","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s12033-007-0052-y","volume":"37","author":"GP Littarru","year":"2007","unstructured":"Littarru GP, Tiano L (2007) Bioenergetic and antioxidant properties of coenzyme Q 10: recent developments. Mol Biotechnol 37:31\u201337","journal-title":"Mol Biotechnol"},{"issue":"30","key":"5542_CR363","doi-asserted-by":"publisher","first-page":"28220","DOI":"10.1074\/jbc.M302297200","volume":"278","author":"L Papucci","year":"2003","unstructured":"Papucci L, Schiavone N, Witort E, Donnini M, Lapucci A, Tempestini A et al (2003) Coenzyme q10 prevents apoptosis by inhibiting mitochondrial depolarization independently of its free radical scavenging property. J Biol Chem 278(30):28220\u201328228","journal-title":"J Biol Chem"},{"issue":"12","key":"5542_CR364","doi-asserted-by":"publisher","first-page":"2076","DOI":"10.1016\/j.jnutbio.2013.07.008","volume":"24","author":"CB Harris","year":"2013","unstructured":"Harris CB, Chowanadisai W, Mishchuk DO, Satre MA, Slupsky CM, Rucker RB (2013) Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects. J Nutr Biochem 24(12):2076\u20132084","journal-title":"J Nutr Biochem"},{"issue":"1","key":"5542_CR365","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1074\/jbc.M109.030130","volume":"285","author":"W Chowanadisai","year":"2010","unstructured":"Chowanadisai W, Bauerly KA, Tchaparian E, Wong A, Cortopassi GA, Rucker RB (2010) Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1\u03b1 expression. J Biol Chem 285(1):142\u2013152","journal-title":"J Biol Chem"},{"issue":"5","key":"5542_CR366","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1038\/s41401-020-0487-2","volume":"42","author":"Q Cheng","year":"2021","unstructured":"Cheng Q, Chen J, Guo H, Lu J-l, Zhou J, Guo X-y et al (2021) Pyrroloquinoline quinone promotes mitochondrial biogenesis in rotenone-induced Parkinson\u2019s disease model via AMPK activation. Acta Pharmacol Sin 42(5):665\u2013678","journal-title":"Acta Pharmacol Sin"},{"issue":"8","key":"5542_CR367","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.3390\/nu11081881","volume":"11","author":"L Perrone","year":"2019","unstructured":"Perrone L, Squillaro T, Napolitano F, Terracciano C, Sampaolo S, Melone MAB (2019) The autophagy signaling pathway: a potential multifunctional therapeutic target of curcumin in neurological and neuromuscular diseases. Nutrients 11(8):1881","journal-title":"Nutrients"},{"key":"5542_CR368","doi-asserted-by":"publisher","first-page":"2237","DOI":"10.1016\/j.biopha.2018.11.075","volume":"109","author":"N Pannu","year":"2019","unstructured":"Pannu N, Bhatnagar A, Resveratrol (2019) From enhanced biosynthesis and bioavailability to multitargeting chronic diseases. Biomed Pharmacother 109:2237\u20132251","journal-title":"Biomed Pharmacother"},{"key":"5542_CR369","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1007\/s00018-015-2101-1","volume":"73","author":"D Lindholm","year":"2016","unstructured":"Lindholm D, M\u00e4kel\u00e4 J, Di Liberto V, Mudo G, Belluardo N, Eriksson O et al (2016) Current disease modifying approaches to treat Parkinson\u2019s disease. Cell Mol Life Sci 73:1365\u20131379","journal-title":"Cell Mol Life Sci"},{"key":"5542_CR370","doi-asserted-by":"publisher","first-page":"2752","DOI":"10.1007\/s12035-016-9843-0","volume":"54","author":"C Van der Merwe","year":"2017","unstructured":"Van der Merwe C, Van Dyk HC, Engelbrecht L, van der Westhuizen FH, Kinnear C, Loos B et al (2017) Curcumin rescues a PINK1 knock down SH-SY5Y cellular model of Parkinson\u2019s disease from mitochondrial dysfunction and cell death. Mol Neurobiol 54:2752\u20132762","journal-title":"Mol Neurobiol"},{"issue":"2","key":"5542_CR371","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.bcp.2009.03.031","volume":"78","author":"J Wang","year":"2009","unstructured":"Wang J, Du X-X, Jiang H, Xie J-X (2009) Curcumin attenuates 6-hydroxydopamine-induced cytotoxicity by anti-oxidation and nuclear factor-kappaB modulation in MES23. 5 cells. Biochem Pharmacol 78(2):178\u2013183","journal-title":"Biochem Pharmacol"},{"issue":"10","key":"5542_CR372","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1080\/10715760500233113","volume":"39","author":"V Zbarsky","year":"2005","unstructured":"Zbarsky V, Datla KP, Parkar S, Rai DK, Aruoma OI, Dexter DT (2005) Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson\u2019s disease. Free Radic Res 39(10):1119\u20131125","journal-title":"Free Radic Res"},{"issue":"5","key":"5542_CR373","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.phrs.2011.01.004","volume":"63","author":"Z Liu","year":"2011","unstructured":"Liu Z, Yu Y, Li X, Ross CA, Smith WW (2011) Curcumin protects against A53T alpha-synuclein-induced toxicity in a PC12 inducible cell model for Parkinsonism. Pharmacol Res 63(5):439\u2013444","journal-title":"Pharmacol Res"},{"issue":"2","key":"5542_CR374","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.taap.2007.09.002","volume":"226","author":"H Raza","year":"2008","unstructured":"Raza H, John A, Brown EM, Benedict S, Kambal A (2008) Alterations in mitochondrial respiratory functions, redox metabolism and apoptosis by oxidant 4-hydroxynonenal and antioxidants curcumin and melatonin in PC12 cells. Toxicol Appl Pharmcol 226(2):161\u2013168","journal-title":"Toxicol Appl Pharmcol"},{"key":"5542_CR375","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.nbd.2014.03.001","volume":"67","author":"IM Williams","year":"2014","unstructured":"Williams IM, Wallom K-L, Smith DA, Al Eisa N, Smith C, Platt FM (2014) Improved neuroprotection using miglustat, curcumin and ibuprofen as a triple combination therapy in Niemann\u2013Pick disease type C1 mice. Neurobiol Dis 67:9\u201317","journal-title":"Neurobiol Dis"},{"issue":"10","key":"5542_CR376","doi-asserted-by":"publisher","first-page":"2451","DOI":"10.3390\/ijms20102451","volume":"20","author":"M Naoi","year":"2019","unstructured":"Naoi M, Wu Y, Shamoto-Nagai M, Maruyama W (2019) Mitochondria in neuroprotection by phytochemicals: Bioactive polyphenols modulate mitochondrial apoptosis system, function and structure. Int J Mol Sci 20(10):2451","journal-title":"Int J Mol Sci"},{"key":"5542_CR377","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.biocel.2018.02.007","volume":"97","author":"J Teixeira","year":"2018","unstructured":"Teixeira J, Deus CM, Borges F, Oliveira PJ (2018) Mitochondria: Targeting mitochondrial reactive oxygen species with mitochondriotropic polyphenolic-based antioxidants. Int J Biochem Cell Biol 97:98\u2013103","journal-title":"Int J Biochem Cell Biol"},{"key":"5542_CR378","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1042\/bse0470069","volume":"47","author":"FR Jornayvaz","year":"2010","unstructured":"Jornayvaz FR, Shulman GI (2010) Regulation of mitochondrial biogenesis. Essays Biochem 47:69\u201384","journal-title":"Essays Biochem"},{"issue":"12","key":"5542_CR379","doi-asserted-by":"publisher","first-page":"e0144290","DOI":"10.1371\/journal.pone.0144290","volume":"10","author":"N Gueguen","year":"2015","unstructured":"Gueguen N, Desquiret-Dumas V, Leman G, Chupin S, Baron S, Nivet-Antoine V et al (2015) Resveratrol directly binds to mitochondrial complex I and increases oxidative stress in brain mitochondria of aged mice. PLoS ONE 10(12):e0144290","journal-title":"PLoS ONE"},{"issue":"12","key":"5542_CR380","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1111\/bph.13492","volume":"174","author":"N Xia","year":"2017","unstructured":"Xia N, Daiber A, F\u00f6rstermann U, Li H (2017) Antioxidant effects of resveratrol in the cardiovascular system. Br J Pharmacol 174(12):1633\u20131646","journal-title":"Br J Pharmacol"},{"issue":"3","key":"5542_CR381","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1159\/000328516","volume":"19","author":"Y Wu","year":"2011","unstructured":"Wu Y, Li X, Zhu JX, Xie W, Le W, Fan Z et al (2011) Resveratrol-activated AMPK\/SIRT1\/autophagy in cellular models of Parkinson\u2019s disease. Neurosignals 19(3):163\u2013174","journal-title":"Neurosignals"},{"issue":"7","key":"5542_CR382","first-page":"902","volume":"1842","author":"A Ferretta","year":"2014","unstructured":"Ferretta A, Gaballo A, Tanzarella P, Piccoli C, Capitanio N, Nico B et al (2014) Effect of resveratrol on mitochondrial function: implications in parkin-associated familiar Parkinson\u2019s disease. Biochim et Biophys Acta (BBA)-Molecular Basis Disease 1842(7):902\u2013915","journal-title":"Biochim et Biophys Acta (BBA)-Molecular Basis Disease"},{"issue":"1","key":"5542_CR383","first-page":"392169","volume":"2015","author":"E Tellone","year":"2015","unstructured":"Tellone E, Galtieri A, Russo A, Giardina B, Ficarra S (2015) Resveratrol: a focus on several neurodegenerative diseases. Oxidative Med Cell Longev 2015(1):392169","journal-title":"Oxidative Med Cell Longev"},{"key":"5542_CR384","doi-asserted-by":"publisher","first-page":"104612","DOI":"10.1016\/j.neuint.2019.104612","volume":"132","author":"E Angelopoulou","year":"2020","unstructured":"Angelopoulou E, Pyrgelis E-S, Piperi C (2020) Neuroprotective potential of chrysin in Parkinson\u2019s disease: Molecular mechanisms and clinical implications. Neurochem Int 132:104612","journal-title":"Neurochem Int"},{"issue":"3","key":"5542_CR385","first-page":"35","volume":"12","author":"MR Ahmed","year":"2018","unstructured":"Ahmed MR, Shaikh MA, Haq SHIU, Nazir S (2018) Neuroprotective role of chrysin in attenuating loss of dopaminergic neurons and improving motor, learning and memory functions in rats. Int J Health Sci 12(3):35","journal-title":"Int J Health Sci"},{"key":"5542_CR386","doi-asserted-by":"crossref","unstructured":"Joshi G, Johnson A (2012) The Nrf2-ARE pathway: a valuable therapeutic target for the treatment of neurodegenerative diseases. Recent patents on CNS drug discovery. 7(3):218\u2013229","DOI":"10.2174\/157488912803252023"},{"key":"5542_CR387","doi-asserted-by":"crossref","unstructured":"Chen P-C, Vargas MR, Pani AK, Smeyne RJ, Johnson DA, Kan YW et al (2009) Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson\u2019s disease: Critical role for the astrocyte. Proceedings of the National Academy of Sciences. ;106(8):2933-8","DOI":"10.1073\/pnas.0813361106"},{"key":"5542_CR388","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.biopha.2016.09.070","volume":"84","author":"S Thangarajan","year":"2016","unstructured":"Thangarajan S, Ramachandran S, Krishnamurthy P (2016) Chrysin exerts neuroprotective effects against 3-Nitropropionic acid induced behavioral despair\u2014Mitochondrial dysfunction and striatal apoptosis via upregulating Bcl-2 gene and downregulating Bax\u2014Bad genes in male wistar rats. Biomed Pharmacother 84:514\u2013525","journal-title":"Biomed Pharmacother"},{"key":"5542_CR389","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.freeradbiomed.2015.02.030","volume":"84","author":"Z Zhang","year":"2015","unstructured":"Zhang Z, Li G, Szeto SS, Chong CM, Quan Q, Huang C et al (2015) Examining the neuroprotective effects of protocatechuic acid and chrysin on in vitro and in vivo models of Parkinson disease. Free Radic Biol Med 84:331\u2013343","journal-title":"Free Radic Biol Med"},{"issue":"5","key":"5542_CR390","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1159\/000447034","volume":"85","author":"AF Carvalho","year":"2016","unstructured":"Carvalho AF, Sharma MS, Brunoni AR, Vieta E, Fava GA (2016) The safety, tolerability and risks associated with the use of newer generation antidepressant drugs: a critical review of the literature. Psychother Psychosom 85(5):270\u2013288","journal-title":"Psychother Psychosom"},{"key":"5542_CR391","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.brainresbull.2018.09.002","volume":"143","author":"L Micheli","year":"2018","unstructured":"Micheli L, Ceccarelli M, D\u2019Andrea G, Tirone F (2018) Depression and adult neurogenesis: Positive effects of the antidepressant fluoxetine and of physical exercise. Brain Res Bull 143:181\u2013193","journal-title":"Brain Res Bull"},{"key":"5542_CR392","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.3389\/fphys.2019.01088","volume":"10","author":"E Balan","year":"2019","unstructured":"Balan E, Schwalm C, Naslain D, Nielens H, Francaux M, Deldicque L (2019) Regular endurance exercise promotes fission, mitophagy, and oxidative phosphorylation in human skeletal muscle independently of age. Front Physiol 10:1088","journal-title":"Front Physiol"},{"key":"5542_CR393","doi-asserted-by":"publisher","first-page":"112049","DOI":"10.1016\/j.bbr.2019.112049","volume":"372","author":"S-S Park","year":"2019","unstructured":"Park S-S, Park H-S, Kim C-J, Baek S-S, Kim T-W (2019) Exercise attenuates maternal separation-induced mood disorder-like behaviors by enhancing mitochondrial functions and neuroplasticity in the dorsal raphe. Behav Brain Res 372:112049","journal-title":"Behav Brain Res"},{"key":"5542_CR394","doi-asserted-by":"publisher","first-page":"113043","DOI":"10.1016\/j.expneurol.2019.113043","volume":"322","author":"J-H Seo","year":"2019","unstructured":"Seo J-H, Park H-S, Park S-S, Kim C-J, Kim D-H, Kim T-W (2019) Physical exercise ameliorates psychiatric disorders and cognitive dysfunctions by hippocampal mitochondrial function and neuroplasticity in post-traumatic stress disorder. Exp Neurol 322:113043","journal-title":"Exp Neurol"},{"key":"5542_CR395","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.exger.2017.01.013","volume":"90","author":"AM Gusdon","year":"2017","unstructured":"Gusdon AM, Callio J, Distefano G, O\u2019Doherty RM, Goodpaster BH, Coen PM et al (2017) Exercise increases mitochondrial complex I activity and DRP1 expression in the brains of aged mice. Exp Gerontol 90:1\u201313","journal-title":"Exp Gerontol"},{"issue":"1","key":"5542_CR396","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3233\/JAD-190328","volume":"72","author":"R Pang","year":"2019","unstructured":"Pang R, Wang X, Pei F, Zhang W, Shen J, Gao X et al (2019) Regular exercise enhances cognitive function and intracephalic GLUT expression in Alzheimer\u2019s disease model mice. J Alzheimer\u2019s Disease 72(1):83\u201396","journal-title":"J Alzheimer\u2019s Disease"},{"issue":"11","key":"5542_CR397","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1101\/lm.030635.113","volume":"20","author":"AR Patten","year":"2013","unstructured":"Patten AR, Sickmann H, Hryciw BN, Kucharsky T, Parton R, Kernick A et al (2013) Long-term exercise is needed to enhance synaptic plasticity in the hippocampus. Learn Mem 20(11):642\u2013647","journal-title":"Learn Mem"},{"issue":"2","key":"5542_CR398","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.stem.2020.10.019","volume":"28","author":"VS Adusumilli","year":"2021","unstructured":"Adusumilli VS, Walker TL, Overall RW, Klatt GM, Zeidan SA, Zocher S et al (2021) ROS dynamics delineate functional states of hippocampal neural stem cells and link to their activity-dependent exit from quiescence. Cell Stem Cell 28(2):300\u2013314 e6","journal-title":"Cell Stem Cell"},{"key":"5542_CR399","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/s00406-019-01025-w","volume":"269","author":"I Maurus","year":"2019","unstructured":"Maurus I, Hasan A, R\u00f6h A, Takahashi S, Rauchmann B, Keeser D et al (2019) Neurobiological effects of aerobic exercise, with a focus on patients with schizophrenia. Eur Arch Psychiatry Clin NeuroSci 269:499\u2013515","journal-title":"Eur Arch Psychiatry Clin NeuroSci"},{"issue":"11","key":"5542_CR400","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1038\/nrn1767","volume":"6","author":"ZB Andrews","year":"2005","unstructured":"Andrews ZB, Diano S, Horvath TL (2005) Mitochondrial uncoupling proteins in the CNS: in support of function and survival. Nat Rev Neurosci 6(11):829\u2013840","journal-title":"Nat Rev Neurosci"},{"key":"5542_CR401","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.neuroscience.2014.04.027","volume":"271","author":"A Aguiar Jr","year":"2014","unstructured":"Aguiar A Jr, Stragier E, da Luz Scheffer D, Remor A, Oliveira P, Prediger R et al (2014) Effects of exercise on mitochondrial function, neuroplasticity and anxio-depressive behavior of mice. Neuroscience 271:56\u201363","journal-title":"Neuroscience"},{"issue":"12","key":"5542_CR402","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.4161\/auto.7.12.17877","volume":"7","author":"P Grumati","year":"2011","unstructured":"Grumati P, Coletto L, Schiavinato A, Castagnaro S, Bertaggia E, Sandri M et al (2011) Physical exercise stimulates autophagy in normal skeletal muscles but is detrimental for collagen VI-deficient muscles. Autophagy 7(12):1415\u20131423","journal-title":"Autophagy"},{"issue":"4","key":"5542_CR403","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1016\/j.neuroscience.2006.01.062","volume":"139","author":"S Vaynman","year":"2006","unstructured":"Vaynman S, Ying Z, Wu A, Gomez-Pinilla F (2006) Coupling energy metabolism with a mechanism to support brain-derived neurotrophic factor-mediated synaptic plasticity. Neuroscience 139(4):1221\u20131234","journal-title":"Neuroscience"},{"issue":"6","key":"5542_CR404","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1111\/cns.13114","volume":"25","author":"J Huang","year":"2019","unstructured":"Huang J, Wang X, Zhu Y, Li Z, Zhu YT, Wu JC et al (2019) Exercise activates lysosomal function in the brain through AMPK-SIRT1\u2010TFEB pathway. CNS Neurosci Ther 25(6):796\u2013807","journal-title":"CNS Neurosci Ther"},{"issue":"1","key":"5542_CR405","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/aps.2013.144","volume":"35","author":"D Jiang","year":"2014","unstructured":"Jiang D, Chen K, Lu X, Gao H-j, Qin Z-h, Lin F (2014) Exercise ameliorates the detrimental effect of chloroquine on skeletal muscles in mice via restoring autophagy flux. Acta Pharmacol Sin 35(1):135\u2013142","journal-title":"Acta Pharmacol Sin"},{"issue":"3","key":"5542_CR406","doi-asserted-by":"publisher","first-page":"212","DOI":"10.3988\/jcn.2015.11.3.212","volume":"11","author":"T Paillard","year":"2015","unstructured":"Paillard T, Rolland Y, de Souto Barreto P (2015) Protective effects of physical exercise in Alzheimer\u2019s disease and Parkinson\u2019s disease: a narrative review. J Clin Neurol 11(3):212\u2013219","journal-title":"J Clin Neurol"},{"issue":"2","key":"5542_CR407","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.neures.2010.10.004","volume":"69","author":"H-S Um","year":"2011","unstructured":"Um H-S, Kang E-B, Koo J-H, Kim H-T, Kim E-J, Yang C-H et al (2011) Treadmill exercise represses neuronal cell death in an aged transgenic mouse model of Alzheimer\u2019s disease. Neurosci Res 69(2):161\u2013173","journal-title":"Neurosci Res"},{"key":"5542_CR408","doi-asserted-by":"crossref","unstructured":"Forbes D, Forbes SC, Blake CM, Thiessen EJ, Forbes S Exercise programs for people with dementia. Cochrane database Syst reviews. 2015(4).","DOI":"10.1002\/14651858.CD006489.pub4"},{"issue":"1","key":"5542_CR409","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7771\/1932-6246.1154","volume":"8","author":"T Tenbrink","year":"2015","unstructured":"Tenbrink T, Taylor HA (2015) Conceptual transformation and cognitive processes in origami paper folding. J Problem Solving 8(1):1","journal-title":"J Problem Solving"},{"key":"5542_CR410","doi-asserted-by":"publisher","first-page":"46","DOI":"10.3389\/fnhum.2012.00046","volume":"6","author":"M Cotelli","year":"2012","unstructured":"Cotelli M, Manenti R, Zanetti O, Miniussi C (2012) Non-pharmacological intervention for memory decline. Front Hum Neurosci 6:46","journal-title":"Front Hum Neurosci"},{"issue":"1","key":"5542_CR411","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.archger.2012.06.016","volume":"56","author":"J Winchester","year":"2013","unstructured":"Winchester J, Dick M, Gillen D, Reed B, Miller B, Tinklenberg J et al (2013) Walking stabilizes cognitive functioning in Alzheimer\u2019s disease (AD) across one year. Arch Gerontol Geriatr 56(1):96\u2013103","journal-title":"Arch Gerontol Geriatr"},{"issue":"3","key":"5542_CR412","first-page":"242","volume":"2","author":"S Chakrabarti","year":"2011","unstructured":"Chakrabarti S, Munshi S, Banerjee K, Thakurta IG, Sinha M, Bagh MB (2011) Mitochondrial dysfunction during brain aging: role of oxidative stress and modulation by antioxidant supplementation. Aging disease 2(3):242","journal-title":"Aging disease"},{"issue":"10","key":"5542_CR413","doi-asserted-by":"publisher","first-page":"932","DOI":"10.3390\/antiox9100932","volume":"9","author":"N Varghese","year":"2020","unstructured":"Varghese N, Werner S, Grimm A, Eckert A (2020) Dietary mitophagy enhancer: a strategy for healthy brain aging? Antioxidants 9(10):932","journal-title":"Antioxidants"},{"issue":"5","key":"5542_CR414","doi-asserted-by":"publisher","first-page":"488","DOI":"10.3390\/cells8050488","volume":"8","author":"PH Reddy","year":"2019","unstructured":"Reddy PH, Oliver DM (2019) Amyloid beta and phosphorylated tau-induced defective autophagy and mitophagy in Alzheimer\u2019s disease. Cells 8(5):488","journal-title":"Cells"},{"issue":"1","key":"5542_CR415","doi-asserted-by":"publisher","first-page":"150","DOI":"10.3390\/cells9010150","volume":"9","author":"Q Cai","year":"2020","unstructured":"Cai Q, Jeong YY (2020) Mitophagy in Alzheimer\u2019s disease and other age-related neurodegenerative diseases. Cells 9(1):150","journal-title":"Cells"},{"key":"5542_CR416","doi-asserted-by":"crossref","unstructured":"Smith C, Carney JM, Starke-Reed P, Oliver C, Stadtman E, Floyd R et al (1991) Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease. Proceedings of the National Academy of Sciences. ;88(23):10540-3","DOI":"10.1073\/pnas.88.23.10540"},{"issue":"1","key":"5542_CR417","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0165-0173(98)00046-0","volume":"29","author":"DS Cassarino","year":"1999","unstructured":"Cassarino DS, Bennett JP Jr (1999) An evaluation of the role of mitochondria in neurodegenerative diseases: mitochondrial mutations and oxidative pathology, protective nuclear responses, and cell death in neurodegeneration. Brain Res Rev 29(1):1\u201325","journal-title":"Brain Res Rev"},{"issue":"2","key":"5542_CR418","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1159\/000022070","volume":"45","author":"T Pepersack","year":"1999","unstructured":"Pepersack T, Garbusinski J, Robberecht J, Beyer I, Willems D, Fuss M (1999) Clinical relevance of thiamine status amongst hospitalized elderly patients. Gerontology 45(2):96\u2013101","journal-title":"Gerontology"},{"issue":"6","key":"5542_CR419","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1016\/j.clnu.2016.10.018","volume":"36","author":"T Kwok","year":"2017","unstructured":"Kwok T, Lee J, Ma RC, Wong SY, Kung K, Lam A et al (2017) A randomized placebo controlled trial of vitamin B12 supplementation to prevent cognitive decline in older diabetic people with borderline low serum vitamin B12. Clin Nutr 36(6):1509\u20131515","journal-title":"Clin Nutr"},{"issue":"2","key":"5542_CR420","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1093\/ajcn\/84.2.361","volume":"84","author":"SJ Eussen","year":"2006","unstructured":"Eussen SJ, de Groot LC, Joosten LW, Bloo RJ, Clarke R, Ueland PM et al (2006) Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial. Am J Clin Nutr 84(2):361\u2013370","journal-title":"Am J Clin Nutr"},{"key":"5542_CR421","doi-asserted-by":"publisher","first-page":"373","DOI":"10.3389\/fncel.2018.00373","volume":"12","author":"R Hornedo-Ortega","year":"2018","unstructured":"Hornedo-Ortega R, Cerezo AB, De Pablos RM, Krisa S, Richard T, Garc\u00eda-Parrilla MC et al (2018) Phenolic compounds characteristic of the mediterranean diet in mitigating microglia-mediated neuroinflammation. Front Cell Neurosci 12:373","journal-title":"Front Cell Neurosci"},{"issue":"20","key":"5542_CR422","doi-asserted-by":"publisher","first-page":"e1789","DOI":"10.1212\/WNL.0000000000005527","volume":"90","author":"V Berti","year":"2018","unstructured":"Berti V, Walters M, Sterling J, Quinn CG, Logue M, Andrews R et al (2018) Mediterranean diet and 3-year Alzheimer brain biomarker changes in middle-aged adults. Neurology 90(20):e1789\u2013e98","journal-title":"Neurology"},{"key":"5542_CR423","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s13668-013-0041-7","volume":"2","author":"F Sofi","year":"2013","unstructured":"Sofi F, Macchi C, Casini A (2013) Mediterranean diet and minimizing neurodegeneration. Curr Nutr Rep 2:75\u201380","journal-title":"Curr Nutr Rep"},{"key":"5542_CR424","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.nut.2018.10.003","volume":"60","author":"GM Broom","year":"2019","unstructured":"Broom GM, Shaw IC, Rucklidge JJ (2019) The ketogenic diet as a potential treatment and prevention strategy for Alzheimer\u2019s disease. Nutrition 60:118\u2013121","journal-title":"Nutrition"},{"issue":"4","key":"5542_CR425","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1002\/ana.20062","volume":"55","author":"PG Sullivan","year":"2004","unstructured":"Sullivan PG, Rippy NA, Dorenbos K, Concepcion RC, Agarwal AK, Rho JM (2004) The ketogenic diet increases mitochondrial uncoupling protein levels and activity. Ann Neurol 55(4):576\u2013580","journal-title":"Ann Neurol"},{"key":"5542_CR426","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1743-7075-6-31","volume":"6","author":"ST Henderson","year":"2009","unstructured":"Henderson ST, Vogel JL, Barr LJ, Garvin F, Jones JJ, Costantini LC (2009) Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer\u2019s disease: a randomized, double-blind, placebo-controlled, multicenter trial. Nutr metabolism 6:1\u201325","journal-title":"Nutr metabolism"},{"key":"5542_CR427","doi-asserted-by":"crossref","unstructured":"Ohnuma T, Toda A, Kimoto A, Takebayashi Y, Higashiyama R, Tagata Y et al (2016) Benefits of use, and tolerance of, medium-chain triglyceride medical food in the management of Japanese patients with Alzheimer\u2019s disease: a prospective, open-label pilot study. Clin Interv Aging :29\u201336","DOI":"10.2147\/CIA.S95362"},{"key":"5542_CR428","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.ebiom.2019.08.032","volume":"47","author":"R Nagpal","year":"2019","unstructured":"Nagpal R, Neth BJ, Wang S, Craft S, Yadav H (2019) Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer\u2019s disease markers in subjects with mild cognitive impairment. EBioMedicine 47:529\u2013542","journal-title":"EBioMedicine"},{"issue":"4","key":"5542_CR429","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1111\/acel.12088","volume":"12","author":"EM Mercken","year":"2013","unstructured":"Mercken EM, Crosby SD, Lamming DW, JeBailey L, Krzysik-Walker S, Villareal DT et al (2013) Calorie restriction in humans inhibits the PI 3 K\/AKT pathway and induces a younger transcription profile. Aging Cell 12(4):645\u2013651","journal-title":"Aging Cell"},{"key":"5542_CR430","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.exger.2014.03.023","volume":"56","author":"H Khraiwesh","year":"2014","unstructured":"Khraiwesh H, L\u00f3pez-Dom\u00ednguez JA, del R\u00edo LF, Gutierrez-Casado E, L\u00f3pez-Lluch G, Navas P et al (2014) Mitochondrial ultrastructure and markers of dynamics in hepatocytes from aged, calorie restricted mice fed with different dietary fats. Exp Gerontol 56:77\u201388","journal-title":"Exp Gerontol"},{"issue":"1","key":"5542_CR431","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/acel.12527","volume":"16","author":"I Amigo","year":"2017","unstructured":"Amigo I, Menezes-Filho SL, Lu\u00e9vano\u2010Mart\u00ednez LA, Chausse B, Kowaltowski AJ (2017) Caloric restriction increases brain mitochondrial calcium retention capacity and protects against excitotoxicity. Aging Cell 16(1):73\u201381","journal-title":"Aging Cell"},{"issue":"1","key":"5542_CR432","doi-asserted-by":"publisher","first-page":"11445","DOI":"10.1038\/ncomms11445","volume":"7","author":"J Cunha-Santos","year":"2016","unstructured":"Cunha-Santos J, Duarte-Neves J, Carmona V, Guarente L, Pereira de Almeida L, Cavadas C (2016) Caloric restriction blocks neuropathology and motor deficits in Machado\u2013Joseph disease mouse models through SIRT1 pathway. Nat Commun 7(1):11445","journal-title":"Nat Commun"},{"issue":"5","key":"5542_CR433","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1016\/j.cell.2010.10.002","volume":"143","author":"S Someya","year":"2010","unstructured":"Someya S, Yu W, Hallows WC, Xu J, Vann JM, Leeuwenburgh C et al (2010) Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell 143(5):802\u2013812","journal-title":"Cell"},{"issue":"13","key":"5542_CR434","doi-asserted-by":"publisher","first-page":"2140","DOI":"10.3390\/nano12132140","volume":"12","author":"A Waris","year":"2022","unstructured":"Waris A, Ali A, Khan AU, Asim M, Zamel D, Fatima K et al (2022) Applications of various types of nanomaterials for the treatment of neurological disorders. Nanomaterials 12(13):2140","journal-title":"Nanomaterials"},{"key":"5542_CR435","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.jconrel.2015.03.036","volume":"207","author":"L Milane","year":"2015","unstructured":"Milane L, Trivedi M, Singh A, Talekar M, Amiji M (2015) Mitochondrial biology, targets, and drug delivery. J Controlled Release 207:40\u201358","journal-title":"J Controlled Release"},{"issue":"23","key":"5542_CR436","doi-asserted-by":"publisher","first-page":"10630","DOI":"10.1021\/acs.jmedchem.9b00939","volume":"62","author":"Z Zhang","year":"2019","unstructured":"Zhang Z, Yu P, Gou Y, Zhang J, Li S, Cai M et al (2019) Novel brain-tumor-inhibiting copper (II) compound based on a human serum albumin (HSA)-cell penetrating peptide conjugate. J Med Chem 62(23):10630\u201310644","journal-title":"J Med Chem"},{"issue":"1","key":"5542_CR437","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1080\/10717544.2018.1561766","volume":"26","author":"H Wang","year":"2019","unstructured":"Wang H, Sun S, Zhang Y, Wang J, Zhang S, Yao X et al (2019) Improved drug targeting to liver tumor by sorafenib-loaded folate-decorated bovine serum albumin nanoparticles. Drug Delivery 26(1):89\u201397","journal-title":"Drug Delivery"},{"issue":"1","key":"5542_CR438","doi-asserted-by":"publisher","first-page":"29601","DOI":"10.1038\/srep29601","volume":"6","author":"Y Nakano","year":"2016","unstructured":"Nakano Y, Matoba T, Tokutome M, Funamoto D, Katsuki S, Ikeda G et al (2016) Nanoparticle-mediated delivery of irbesartan induces cardioprotection from myocardial ischemia-reperfusion injury by antagonizing monocyte-mediated inflammation. Sci Rep 6(1):29601","journal-title":"Sci Rep"},{"key":"5542_CR439","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.jconrel.2014.03.058","volume":"190","author":"K Kajimoto","year":"2014","unstructured":"Kajimoto K, Sato Y, Nakamura T, Yamada Y, Harashima H (2014) Multifunctional envelope-type nano device for controlled intracellular trafficking and selective targeting in vivo. J Controlled Release 190:593\u2013606","journal-title":"J Controlled Release"},{"key":"5542_CR440","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.addr.2019.02.007","volume":"148","author":"C Vissers","year":"2019","unstructured":"Vissers C, Ming G-l, Song H (2019) Nanoparticle technology and stem cell therapy team up against neurodegenerative disorders. Adv Drug Deliv Rev 148:239\u2013251","journal-title":"Adv Drug Deliv Rev"},{"issue":"1","key":"5542_CR441","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.drudis.2019.09.005","volume":"25","author":"N Kiaie","year":"2020","unstructured":"Kiaie N, Gorabi AM, Penson PE, Watts G, Johnston TP, Banach M et al (2020) A new approach to the diagnosis and treatment of atherosclerosis: the era of the liposome. Drug Discovery Today 25(1):58\u201372","journal-title":"Drug Discovery Today"},{"issue":"14","key":"5542_CR442","doi-asserted-by":"publisher","first-page":"11070","DOI":"10.1039\/C5RA19521G","volume":"6","author":"F Guo","year":"2016","unstructured":"Guo F, Yu M, Wang J, Tan F, Li N (2016) The mitochondria-targeted and IR780-regulated theranosomes for imaging and enhanced photodynamic\/photothermal therapy. RSC Adv 6(14):11070\u201311076","journal-title":"RSC Adv"},{"issue":"8","key":"5542_CR443","doi-asserted-by":"publisher","first-page":"2559","DOI":"10.1021\/nl801908y","volume":"8","author":"SV Boddapati","year":"2008","unstructured":"Boddapati SV, D\u2019Souza GG, Erdogan S, Torchilin VP, Weissig V (2008) Organelle-targeted nanocarriers: specific delivery of liposomal ceramide to mitochondria enhances its cytotoxicity in vitro and in vivo. Nano Lett 8(8):2559\u20132563","journal-title":"Nano Lett"},{"issue":"3","key":"5542_CR444","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.jconrel.2012.01.009","volume":"159","author":"S Biswas","year":"2012","unstructured":"Biswas S, Dodwadkar NS, Deshpande PP, Torchilin VP (2012) Liposomes loaded with paclitaxel and modified with novel triphenylphosphonium-PEG-PE conjugate possess low toxicity, target mitochondria and demonstrate enhanced antitumor effects in vitro and in vivo. J Controlled Release 159(3):393\u2013402","journal-title":"J Controlled Release"},{"issue":"2","key":"5542_CR445","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.bbamem.2007.11.002","volume":"1778","author":"Y Yamada","year":"2008","unstructured":"Yamada Y, Akita H, Kamiya H, Kogure K, Yamamoto T, Shinohara Y et al (2008) MITO-Porter: A liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion. Biochim et Biophys Acta (BBA)-Biomembranes 1778(2):423\u2013432","journal-title":"Biochim et Biophys Acta (BBA)-Biomembranes"},{"issue":"2","key":"5542_CR446","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.bbrc.2010.05.070","volume":"397","author":"Y Yasuzaki","year":"2010","unstructured":"Yasuzaki Y, Yamada Y, Harashima H (2010) Mitochondrial matrix delivery using MITO-Porter, a liposome-based carrier that specifies fusion with mitochondrial membranes. Biochem Biophys Res Commun 397(2):181\u2013186","journal-title":"Biochem Biophys Res Commun"},{"key":"5542_CR447","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.mito.2020.09.008","volume":"55","author":"Y Yamada","year":"2020","unstructured":"Yamada Y, Maruyama M, Kita T, Usami S-i, Kitajiri S-i, Harashima H (2020) The use of a MITO-Porter to deliver exogenous therapeutic RNA to a mitochondrial disease\u2019s cell with a A1555G mutation in the mitochondrial 12S rRNA gene results in an increase in mitochondrial respiratory activity. Mitochondrion 55:134\u2013144","journal-title":"Mitochondrion"},{"issue":"20","key":"5542_CR448","doi-asserted-by":"publisher","first-page":"5919","DOI":"10.1039\/D1NA00427A","volume":"3","author":"Y Takano","year":"2021","unstructured":"Takano Y, Hirata E, Ushijima N, Harashima H, Yamada Y (2021) An effective in vivo mitochondria-targeting nanocarrier combined with a \u03c0-extended porphyrin-type photosensitizer. Nanoscale Adv 3(20):5919\u20135927","journal-title":"Nanoscale Adv"},{"key":"5542_CR449","doi-asserted-by":"crossref","unstructured":"Weissig V (2015) DQAsomes as the prototype of mitochondria-targeted pharmaceutical nanocarriers: Preparation, characterization, and use. Springer","DOI":"10.1007\/978-1-4939-2288-8_1"},{"issue":"7","key":"5542_CR450","doi-asserted-by":"publisher","first-page":"2334","DOI":"10.1021\/mp500003q","volume":"11","author":"S Zupancic","year":"2014","unstructured":"Zupancic S, Kocbek P, Zariwala MG, Renshaw D, Gul MO, Elsaid Z et al (2014) Design and development of novel mitochondrial targeted nanocarriers, DQAsomes for curcumin inhalation. Mol Pharm 11(7):2334\u20132345","journal-title":"Mol Pharm"},{"issue":"1\u20132","key":"5542_CR451","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S0168-3659(03)00297-9","volume":"92","author":"GG D\u2019Souza","year":"2003","unstructured":"D\u2019Souza GG, Rammohan R, Cheng S-M, Torchilin VP, Weissig V (2003) DQAsome-mediated delivery of plasmid DNA toward mitochondria in living cells. J Controlled Release 92(1\u20132):189\u2013197","journal-title":"J Controlled Release"},{"issue":"1","key":"5542_CR452","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/107175400266722","volume":"7","author":"V Weissig","year":"2000","unstructured":"Weissig V, Lizano C, Torchilin VP (2000) Selective DNA release from DQAsome\/DNA complexes at mitochondria-like membranes. Drug Delivery 7(1):1\u20135","journal-title":"Drug Delivery"},{"issue":"5","key":"5542_CR453","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1038\/sj.clpt.6100400","volume":"83","author":"L Zhang","year":"2008","unstructured":"Zhang L, Gu F, Chan J, Wang A, Langer R, Farokhzad O (2008) Nanoparticles in medicine: therapeutic applications and developments. Clin Pharmacol Ther 83(5):761\u2013769","journal-title":"Clin Pharmacol Ther"},{"issue":"11","key":"5542_CR454","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.2174\/092986652111140930171353","volume":"21","author":"Y Tutar","year":"2014","unstructured":"Tutar Y (2014) Editorial (Thematic Issue: Controlled Release and Drug Delivery in Diseases). Protein Pept Lett 21(11):1085\u20131086","journal-title":"Protein Pept Lett"},{"issue":"3","key":"5542_CR455","first-page":"315","volume":"7","author":"RK Pathak","year":"2015","unstructured":"Pathak RK, Kolishetti N, Dhar S (2015) Targeted nanoparticles in mitochondrial medicine. Wiley Interdisciplinary Reviews: Nanomed Nanobiotechnol 7(3):315\u2013329","journal-title":"Wiley Interdisciplinary Reviews: Nanomed Nanobiotechnol"},{"key":"5542_CR456","doi-asserted-by":"crossref","unstructured":"Marrache S, Dhar S (2012) Engineering of blended nanoparticle platform for delivery of mitochondria-acting therapeutics. Proceedings of the National Academy of Sciences. ;109(40):16288-93","DOI":"10.1073\/pnas.1210096109"},{"issue":"2","key":"5542_CR457","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1021\/acs.molpharmaceut.8b01014","volume":"16","author":"M Velichkovska","year":"2018","unstructured":"Velichkovska M, Surnar B, Nair M, Dhar S, Toborek M (2018) Targeted mitochondrial COQ10 delivery attenuates antiretroviral-drug-induced senescence of neural progenitor cells. Mol Pharm 16(2):724\u2013736","journal-title":"Mol Pharm"},{"key":"5542_CR458","doi-asserted-by":"publisher","first-page":"119844","DOI":"10.1016\/j.biomaterials.2020.119844","volume":"238","author":"P Yang","year":"2020","unstructured":"Yang P, Sheng D, Guo Q, Wang P, Xu S, Qian K et al (2020) Neuronal mitochondria-targeted micelles relieving oxidative stress for delayed progression of Alzheimer\u2019s disease. Biomaterials 238:119844","journal-title":"Biomaterials"},{"key":"5542_CR459","doi-asserted-by":"publisher","first-page":"119752","DOI":"10.1016\/j.biomaterials.2019.119752","volume":"232","author":"C Ren","year":"2020","unstructured":"Ren C, Li D, Zhou Q, Hu X (2020) Mitochondria-targeted TPP-MoS2 with dual enzyme activity provides efficient neuroprotection through M1\/M2 microglial polarization in an Alzheimer\u2019s disease model. Biomaterials 232:119752","journal-title":"Biomaterials"},{"issue":"12","key":"5542_CR460","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1111\/j.1348-0421.2004.tb03621.x","volume":"48","author":"A Hoshino","year":"2004","unstructured":"Hoshino A, Fujioka K, Oku T, Nakamura S, Suga M, Yamaguchi Y et al (2004) Quantum dots targeted to the assigned organelle in living cells. Microbiol Immunol 48(12):985\u2013994","journal-title":"Microbiol Immunol"},{"key":"5542_CR461","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cis.2017.02.005","volume":"242","author":"Y Zheng","year":"2017","unstructured":"Zheng Y, Lai L, Liu W, Jiang H, Wang X (2017) Recent advances in biomedical applications of fluorescent gold nanoclusters. Adv Colloid Interface Sci 242:1\u201316","journal-title":"Adv Colloid Interface Sci"},{"key":"5542_CR462","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1007\/s12035-019-01780-w","volume":"57","author":"N dos Santos Tramontin","year":"2020","unstructured":"dos Santos Tramontin N, da Silva S, Arruda R, Ugioni KS, Canteiro PB, de Bem Silveira G et al (2020) Gold nanoparticles treatment reverses brain damage in Alzheimer\u2019s disease model. Mol Neurobiol 57:926\u2013936","journal-title":"Mol Neurobiol"},{"issue":"1","key":"5542_CR463","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1021\/acs.nanolett.9b04216","volume":"20","author":"L Xiao","year":"2019","unstructured":"Xiao L, Wei F, Zhou Y, Anderson GJ, Frazer DM, Lim YC et al (2019) Dihydrolipoic acid\u2013gold nanoclusters regulate microglial polarization and have the potential to alter neurogenesis. Nano Lett 20(1):478\u2013495","journal-title":"Nano Lett"},{"issue":"1","key":"5542_CR464","doi-asserted-by":"publisher","first-page":"502386","DOI":"10.4061\/2011\/502386","volume":"2011","author":"G Thakur","year":"2011","unstructured":"Thakur G, Micic M, Yang Y, Li W, Movia D, Giordani S et al (2011) Conjugated quantum dots inhibit the amyloid \u03b2 (1\u201342) fibrillation process. Int J Alzheimer\u2019s disease 2011(1):502386","journal-title":"Int J Alzheimer\u2019s disease"},{"key":"5542_CR465","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s40820-021-00674-8","volume":"13","author":"Q Liu","year":"2021","unstructured":"Liu Q, Zhang A, Wang R, Zhang Q, Cui D (2021) A review on metal-and metal oxide-based nanozymes: properties, mechanisms, and applications. Nano-micro Lett 13:1\u201353","journal-title":"Nano-micro Lett"},{"issue":"2","key":"5542_CR466","doi-asserted-by":"publisher","first-page":"2860","DOI":"10.1021\/acsnano.5b08045","volume":"10","author":"HJ Kwon","year":"2016","unstructured":"Kwon HJ, Cha M-Y, Kim D, Kim DK, Soh M, Shin K et al (2016) Mitochondria-targeting ceria nanoparticles as antioxidants for Alzheimer\u2019s disease. ACS Nano 10(2):2860\u20132870","journal-title":"ACS Nano"},{"issue":"30","key":"5542_CR467","doi-asserted-by":"publisher","first-page":"9408","DOI":"10.1002\/anie.201805052","volume":"57","author":"HJ Kwon","year":"2018","unstructured":"Kwon HJ, Kim D, Seo K, Kim YG, Han SI, Kang T et al (2018) Ceria Nanoparticle Systems for Selective Scavenging of Mitochondrial, Intracellular, and Extracellular Reactive Oxygen Species in Parkinson\u2019s Disease. Angew Chem Int Ed Engl 57(30):9408\u20139412","journal-title":"Angew Chem Int Ed Engl"},{"key":"5542_CR468","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.biomaterials.2019.01.037","volume":"197","author":"L Zhang","year":"2019","unstructured":"Zhang L, Zhao P, Yue C, Jin Z, Liu Q, Du X et al (2019) Sustained release of bioactive hydrogen by Pd hydride nanoparticles overcomes Alzheimer\u2019s disease. Biomaterials 197:393\u2013404","journal-title":"Biomaterials"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-026-05542-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-026-05542-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-026-05542-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T10:03:00Z","timestamp":1787911380000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-026-05542-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,27]]},"references-count":468,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["5542"],"URL":"https:\/\/doi.org\/10.1007\/s11010-026-05542-w","relation":{},"ISSN":["1573-4919"],"issn-type":[{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,27]]},"assertion":[{"value":"23 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}