{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T09:53:59Z","timestamp":1781776439864,"version":"3.54.5"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Shanghai Association of Integrated Chinese and Western Medicine, Community Medicine and Health Management Research Project Special Fund Project"},{"name":"2022 National Key Research and Development Program of China","award":["2022YFC3600903"],"award-info":[{"award-number":["2022YFC3600903"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"DOI":"10.1007\/s11010-026-05555-5","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:50:29Z","timestamp":1777373429000},"page":"2607-2612","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between obstructive sleep apnea, high-sensitivity c-reactive protein, and mitral annular calcification: a cross-sectional analysis of 200 adults undergoing routine medical evaluation"],"prefix":"10.1007","volume":"481","author":[{"given":"Jinyu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aicheng","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengkai","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"issue":"6","key":"5555_CR1","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1056\/NEJM199208063270602","volume":"327","author":"EJ Benjamin","year":"1992","unstructured":"Benjamin EJ, Plehn JF, D\u2019Agostino RB et al (1992) Mitral annular calcification and the risk of stroke in an elderly cohort. N Engl J Med 327(6):374\u2013379. https:\/\/doi.org\/10.1056\/NEJM199208063270602","journal-title":"N Engl J Med"},{"issue":"17","key":"5555_CR2","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1016\/j.jacc.2015.08.872","volume":"66","author":"Y Abramowitz","year":"2015","unstructured":"Abramowitz Y, Jilaihawi H, Chakravarty T, Mack MJ, Makkar RR (2015) Mitral annulus calcification. J Am Coll Cardiol 66(17):1934\u20131941. https:\/\/doi.org\/10.1016\/j.jacc.2015.08.872","journal-title":"J Am Coll Cardiol"},{"key":"5555_CR3","doi-asserted-by":"publisher","unstructured":"Somers VK, White DP, Amin R, et al (2008) Sleep apnea and cardiovascular disease: an American Heart Association\/american College Of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council On Cardiovascular Nursing. In collaboration with the National Heart, Lung, and Blood Institute National Center on Sleep Disorders Research (National Institutes of Health). Circulation 118(10):1080\u20131111 https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.107.189375","DOI":"10.1161\/CIRCULATIONAHA.107.189375"},{"key":"5555_CR4","doi-asserted-by":"publisher","first-page":"15015","DOI":"10.1038\/nrdp.2015.15","volume":"1","author":"P L\u00e9vy","year":"2015","unstructured":"L\u00e9vy P, Kohler M, McNicholas WT et al (2015) Obstructive sleep apnoea syndrome. Nat Rev Dis Primers 1:15015. https:\/\/doi.org\/10.1038\/nrdp.2015.15","journal-title":"Nat Rev Dis Primers"},{"issue":"21","key":"5555_CR5","doi-asserted-by":"publisher","first-page":"2462","DOI":"10.1161\/01.cir.0000018948.95175.03","volume":"105","author":"AS Shamsuzzaman","year":"2002","unstructured":"Shamsuzzaman AS, Winnicki M, Lanfranchi P et al (2002) Elevated C-reactive protein in patients with obstructive sleep apnea. Circulation 105(21):2462\u20132464. https:\/\/doi.org\/10.1161\/01.cir.0000018948.95175.03","journal-title":"Circulation"},{"issue":"3","key":"5555_CR6","doi-asserted-by":"publisher","first-page":"479","DOI":"10.5664\/jcsm.6506","volume":"13","author":"VK Kapur","year":"2017","unstructured":"Kapur VK, Auckley DH, Chowdhuri S et al (2017) Clinical Practice Guideline for Diagnostic Testing for Adult Obstructive Sleep Apnea: An American Academy of Sleep Medicine Clinical Practice Guideline. J Clin Sleep Med 13(3):479\u2013504. https:\/\/doi.org\/10.5664\/jcsm.6506","journal-title":"J Clin Sleep Med"},{"issue":"18","key":"5555_CR7","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1016\/j.jcin.2023.06.044","volume":"16","author":"ME Guerrero","year":"2023","unstructured":"Guerrero ME, Grayburn P, Smith RL II et al (2023) Diagnosis, Classification, and Management Strategies for Mitral Annular Calcification: A Heart Valve Collaboratory Position Statement. JACC Cardiovasc Interv 16(18):2195\u20132210. https:\/\/doi.org\/10.1016\/j.jcin.2023.06.044","journal-title":"JACC Cardiovasc Interv"},{"issue":"1","key":"5555_CR8","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1038\/s42003-025-08226-1","volume":"8","author":"Z Wang","year":"2025","unstructured":"Wang Z, Wallace DA, Spitzer BW et al (2025) Methylation risk score of C-reactive protein associates sleep health with related health outcomes. Commun Biol 8(1):821. https:\/\/doi.org\/10.1038\/s42003-025-08226-1","journal-title":"Commun Biol"},{"issue":"1","key":"5555_CR9","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1186\/s13643-021-01759-6","volume":"10","author":"M Lu","year":"2021","unstructured":"Lu M, Wang Z, Zhan X, Wei Y (2021) Obstructive sleep apnea increases the risk of cardiovascular damage: a systematic review and meta-analysis of imaging studies. Syst Rev 10(1):212. https:\/\/doi.org\/10.1186\/s13643-021-01759-6","journal-title":"Syst Rev"},{"issue":"4","key":"5555_CR10","doi-asserted-by":"publisher","first-page":"362","DOI":"10.3390\/life11040362","volume":"11","author":"MM Imani","year":"2021","unstructured":"Imani MM, Sadeghi M, Farokhzadeh F et al (2021) Evaluation of blood levels of C-reactive protein marker in obstructive sleep apnea: a systematic review, meta-analysis and meta-regression. Life (Basel) 11(4):362. https:\/\/doi.org\/10.3390\/life11040362","journal-title":"Life (Basel)"},{"issue":"6","key":"5555_CR11","doi-asserted-by":"publisher","first-page":"423","DOI":"10.21037\/acs-2025-mac-12","volume":"14","author":"M Reisinger","year":"2025","unstructured":"Reisinger M, Kachel M, Kanade R et al (2025) Mitral annular calcification: implications on clinical outcomes and interventions. Ann Cardiothorac Surg 14(6):423\u2013437. https:\/\/doi.org\/10.21037\/acs-2025-mac-12","journal-title":"Ann Cardiothorac Surg"},{"issue":"1","key":"5555_CR12","doi-asserted-by":"publisher","first-page":"57","DOI":"10.5664\/jcsm.3360","volume":"10","author":"YL Chen","year":"2014","unstructured":"Chen YL, Liu KH, Lin CC et al (2014) Influence and predicting variables of obstructive sleep apnea on cardiac function and remodeling in patients without congestive heart failure. J Clin Sleep Med 10(1):57\u201364. https:\/\/doi.org\/10.5664\/jcsm.3360","journal-title":"J Clin Sleep Med"},{"key":"5555_CR13","doi-asserted-by":"publisher","first-page":"1168339","DOI":"10.3389\/fcvm.2023.1168339","volume":"10","author":"DM Csiki","year":"2023","unstructured":"Csiki DM, Ababneh H, T\u00f3th A et al (2023) Hypoxia-inducible factor activation promotes osteogenic transition of valve interstitial cells and accelerates aortic valve calcification in a mice model of chronic kidney disease. Front Cardiovasc Med 10:1168339. https:\/\/doi.org\/10.3389\/fcvm.2023.1168339","journal-title":"Front Cardiovasc Med"},{"issue":"10","key":"5555_CR14","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1016\/j.amjcard.2005.11.086","volume":"97","author":"CS Fox","year":"2006","unstructured":"Fox CS, Guo CY, Larson MG et al (2006) Relations of inflammation and novel risk factors to valvular calcification. Am J Cardiol 97(10):1502\u20131505. https:\/\/doi.org\/10.1016\/j.amjcard.2005.11.086","journal-title":"Am J Cardiol"},{"issue":"3","key":"5555_CR15","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/nrcardio.2016.185","volume":"14","author":"N Ruparelia","year":"2017","unstructured":"Ruparelia N, Chai JT, Fisher EA, Choudhury RP (2017) Inflammatory processes in cardiovascular disease: a route to targeted therapies. Nat Rev Cardiol 14(3):133\u2013144. https:\/\/doi.org\/10.1038\/nrcardio.2016.185","journal-title":"Nat Rev Cardiol"},{"issue":"15","key":"5555_CR16","doi-asserted-by":"publisher","first-page":"5445","DOI":"10.18632\/aging.102130","volume":"11","author":"LA Henze","year":"2019","unstructured":"Henze LA, Luong TT, Boehme B et al (2019) Impact of C-reactive protein on osteo-\/chondrogenic transdifferentiation and calcification of vascular smooth muscle cells. Aging 11(15):5445\u20135462. https:\/\/doi.org\/10.18632\/aging.102130","journal-title":"Aging"},{"issue":"10","key":"5555_CR17","doi-asserted-by":"publisher","first-page":"2920","DOI":"10.1681\/ASN.2004100895","volume":"16","author":"JL Reynolds","year":"2005","unstructured":"Reynolds JL, Skepper JN, McNair R et al (2005) Multifunctional roles for serum protein fetuin-a in inhibition of human vascular smooth muscle cell calcification. J Am Soc Nephrol 16(10):2920\u20132930. https:\/\/doi.org\/10.1681\/ASN.2004100895","journal-title":"J Am Soc Nephrol"},{"issue":"7","key":"5555_CR18","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/s41569-019-0169-2","volume":"16","author":"M B\u00e4ck","year":"2019","unstructured":"B\u00e4ck M, Yurdagul A Jr, Tabas I, \u00d6\u00f6rni K, Kovanen PT (2019) Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities. Nat Rev Cardiol 16(7):389\u2013406. https:\/\/doi.org\/10.1038\/s41569-019-0169-2","journal-title":"Nat Rev Cardiol"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-026-05555-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-026-05555-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-026-05555-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T09:02:24Z","timestamp":1781773344000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-026-05555-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":18,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["5555"],"URL":"https:\/\/doi.org\/10.1007\/s11010-026-05555-5","relation":{},"ISSN":["1573-4919"],"issn-type":[{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,28]]},"assertion":[{"value":"10 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was conducted with approval from the Ethics Committee of Shanghai Health and Medical Center (Huadong Sanatorium)[(2026) Lun Yan Pi Hui No.1]. This study was conducted in accordance with the declaration of Helsinki. Written informed consent was obtained from all participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}