{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:52:32Z","timestamp":1791247952649,"version":"4.1.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Key project of the Hunan Provincial Administration of Traditional Chinese Medicine","award":["A2023033 and C20222028"],"award-info":[{"award-number":["A2023033 and C20222028"]}],"id":[{"id":"https:\/\/ror.org\/03x55t826","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Keyao Joint Project of Hunan Natural Science Foundation","award":["2021JJ80063"],"award-info":[{"award-number":["2021JJ80063"]}]},{"name":"Wang Zhuxin National Senior Traditional Pharmacist Inheritance Studio"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"DOI":"10.1007\/s11010-026-05654-3","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T08:31:08Z","timestamp":1784881868000},"page":"4273-4288","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic potential of polygonatum polysaccharides in modulating gut microbiota and alleviating psoriasis-like inflammation in a mouse model"],"prefix":"10.1007","volume":"481","author":[{"given":"Yi","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinglan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuxin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijun","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"issue":"9997","key":"5654_CR1","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/S0140-6736(14)61909-7","volume":"386","author":"WH Boehncke","year":"2015","unstructured":"Boehncke WH, Schon MP, Psoriasis (2015) Lancet 386(9997):983\u2013994","journal-title":"Lancet"},{"issue":"2","key":"5654_CR2","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1111\/jdv.13854","volume":"31","author":"IM Michalek","year":"2017","unstructured":"Michalek IM, Loring B, John SM (2017) A systematic review of worldwide epidemiology of psoriasis. J Eur Acad Dermatol Venereol 31(2):205\u2013212","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"4","key":"5654_CR3","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.rdc.2015.07.006","volume":"41","author":"JL Barnas","year":"2015","unstructured":"Barnas JL, Ritchlin CT (2015) Etiology and Pathogenesis of Psoriatic Arthritis. Rheum Dis Clin North Am 41(4):643\u2013663","journal-title":"Rheum Dis Clin North Am"},{"issue":"4","key":"5654_CR4","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.rdc.2015.07.013","volume":"41","author":"WH Boehncke","year":"2015","unstructured":"Boehncke WH (2015) Etiology and Pathogenesis of Psoriasis. Rheum Dis Clin North Am 41(4):665\u2013675","journal-title":"Rheum Dis Clin North Am"},{"issue":"1","key":"5654_CR5","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/s41419-022-04523-3","volume":"13","author":"X Zhou","year":"2022","unstructured":"Zhou X, Chen Y, Cui L, Shi Y, Guo C (2022) Advances in the pathogenesis of psoriasis: from keratinocyte perspective. Cell Death Dis 13(1):81","journal-title":"Cell Death Dis"},{"key":"5654_CR6","doi-asserted-by":"crossref","unstructured":"Buhas MC, Gavrilas LI, Candrea R, Catinean A, Mocan A, Miere D et al (2022) Gut Microbiota Psoriasis Nutrients 14(14)","DOI":"10.3390\/nu14142970"},{"key":"5654_CR7","doi-asserted-by":"publisher","first-page":"108537","DOI":"10.1016\/j.clim.2020.108537","volume":"218","author":"ST Le","year":"2020","unstructured":"Le ST, Toussi A, Maverakis N, Marusina AI, Barton VR, Merleev AA et al (2020) The cutaneous and intestinal microbiome in psoriatic disease. Clin Immunol 218:108537","journal-title":"Clin Immunol"},{"issue":"11","key":"5654_CR8","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1111\/exd.14016","volume":"28","author":"M Szanto","year":"2019","unstructured":"Szanto M, Dozsa A, Antal D, Szabo K, Kemeny L, Bai P (2019) Targeting the gut-skin axis-Probiotics as new tools for skin disorder management? Exp Dermatol 28(11):1210\u20131218","journal-title":"Exp Dermatol"},{"key":"5654_CR9","doi-asserted-by":"crossref","unstructured":"Sikora M, Stec A, Chrabaszcz M, Knot A, Waskiel-Burnat A, Rakowska A et al (2020) Gut Microbiome Psoriasis: Updated Rev Pathogens (Basel Switzerland) 9(6)","DOI":"10.3390\/pathogens9060463"},{"key":"5654_CR10","doi-asserted-by":"publisher","first-page":"223","DOI":"10.3389\/fcimb.2020.00223","volume":"10","author":"K Bojovic","year":"2020","unstructured":"Bojovic K, Ignjatovic Eth I, Sokovic Bajic S, Vojnovic Milutinovic D, Tomic M, Golic N et al (2020) Gut Microbiota Dysbiosis Associated With Altered Production of Short Chain Fatty Acids in Children With Neurodevelopmental Disorders. Front Cell Infect Microbiol 10:223","journal-title":"Front Cell Infect Microbiol"},{"issue":"1","key":"5654_CR11","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1002\/art.38892","volume":"67","author":"JU Scher","year":"2015","unstructured":"Scher JU, Ubeda C, Artacho A, Attur M, Isaac S, Reddy SM et al (2015) Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease. Arthritis Rheumatol 67(1):128\u2013139","journal-title":"Arthritis Rheumatol"},{"issue":"7","key":"5654_CR12","doi-asserted-by":"publisher","first-page":"e0159539","DOI":"10.1371\/journal.pone.0159539","volume":"11","author":"Z Zakostelska","year":"2016","unstructured":"Zakostelska Z, Malkova J, Klimesova K, Rossmann P, Hornova M, Novosadova I et al (2016) Intestinal Microbiota Promotes Psoriasis-Like Skin Inflammation by Enhancing Th17 Response. PLoS ONE 11(7):e0159539","journal-title":"PLoS ONE"},{"issue":"2","key":"5654_CR13","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1007\/s13671-017-0178-5","volume":"6","author":"D Yan","year":"2017","unstructured":"Yan D, Issa N, Afifi L, Jeon C, Chang HW, Liao W (2017) The Role of the Skin and Gut Microbiome in Psoriatic Disease. Curr Dermatol Rep 6(2):94\u2013103","journal-title":"Curr Dermatol Rep"},{"key":"5654_CR14","doi-asserted-by":"publisher","first-page":"105970","DOI":"10.1016\/j.micpath.2023.105970","volume":"175","author":"C Wen","year":"2023","unstructured":"Wen C, Pan Y, Gao M, Wang J, Huang K, Tu P (2023) Altered gut microbiome composition in nontreated plaque psoriasis patients. Microb Pathog 175:105970","journal-title":"Microb Pathog"},{"key":"5654_CR15","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/j.ijbiomac.2022.12.320","volume":"229","author":"H Gong","year":"2023","unstructured":"Gong H, Gan X, Li Y, Chen J, Xu Y, Shi S et al (2023) Review on the genus Polygonatum polysaccharides: Extraction, purification, structural characteristics and bioactivities. Int J Biol Macromol 229:909\u2013930","journal-title":"Int J Biol Macromol"},{"key":"5654_CR16","doi-asserted-by":"publisher","first-page":"758870","DOI":"10.3389\/fmicb.2021.758870","volume":"12","author":"M Yang","year":"2021","unstructured":"Yang M, Meng F, Gu W, Fu L, Zhang F, Li F et al (2021) Influence of Polysaccharides From Polygonatum kingianum on Short-Chain Fatty Acid Production and Quorum Sensing in Lactobacillus faecis. Front Microbiol 12:758870","journal-title":"Front Microbiol"},{"issue":"17","key":"5654_CR17","doi-asserted-by":"publisher","first-page":"9880","DOI":"10.1021\/acs.jafc.4c00372","volume":"72","author":"T Liu","year":"2024","unstructured":"Liu T, Zhou L, Li X, Song W, Liu Y, Wu S et al (2024) Polygonatum kingianum Polysaccharides Enhance the Preventive Efficacy of Heat-Inactivated Limosilactobacillus reuteri WX-94 against High-Fat-High-Sucrose-Induced Liver Injury and Gut Dysbacteriosis. J Agric Food Chem 72(17):9880\u20139892","journal-title":"J Agric Food Chem"},{"key":"5654_CR18","doi-asserted-by":"publisher","first-page":"992102","DOI":"10.3389\/fnut.2022.992102","volume":"9","author":"LX Li","year":"2022","unstructured":"Li LX, Feng X, Tao MT, Paulsen BS, Huang C, Feng B et al (2022) Benefits of neutral polysaccharide from rhizomes of Polygonatum sibiricum to intestinal function of aged mice. Front Nutr 9:992102","journal-title":"Front Nutr"},{"key":"5654_CR19","doi-asserted-by":"publisher","first-page":"121669","DOI":"10.1016\/j.carbpol.2023.121669","volume":"327","author":"H Gong","year":"2024","unstructured":"Gong H, Gan X, Qin B, Chen J, Zhao Y, Qiu B et al (2024) Structural characteristics of steamed Polygonatum cyrtonema polysaccharide and its bioactivity on colitis via improving the intestinal barrier and modifying the gut microbiota. Carbohydr Polym 327:121669","journal-title":"Carbohydr Polym"},{"issue":"11","key":"5654_CR20","doi-asserted-by":"publisher","first-page":"6974","DOI":"10.1002\/fsn3.3622","volume":"11","author":"JR Liu","year":"2023","unstructured":"Liu JR, Chen BX, Jiang MT, Cui TY, Lv B, Fu ZF et al (2023) Polygonatum odoratum polysaccharide attenuates lipopolysaccharide-induced lung injury in mice by regulating gut microbiota. Food Sci Nutr 11(11):6974\u20136986","journal-title":"Food Sci Nutr"},{"issue":"1","key":"5654_CR21","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/s41392-023-01655-6","volume":"8","author":"J Guo","year":"2023","unstructured":"Guo J, Zhang H, Lin W, Lu L, Su J, Chen X (2023) Signaling pathways and targeted therapies for psoriasis. Signal Transduct Target Ther 8(1):437","journal-title":"Signal Transduct Target Ther"},{"issue":"Pt A","key":"5654_CR22","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.ijbiomac.2017.09.051","volume":"107","author":"N Liu","year":"2018","unstructured":"Liu N, Dong Z, Zhu X, Xu H, Zhao Z (2018) Characterization and protective effect of Polygonatum sibiricum polysaccharide against cyclophosphamide-induced immunosuppression in Balb\/c mice. Int J Biol Macromol 107(Pt A):796\u2013802","journal-title":"Int J Biol Macromol"},{"issue":"1","key":"5654_CR23","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1080\/13880209.2021.1893347","volume":"59","author":"Z Zhang","year":"2021","unstructured":"Zhang Z, Yang B, Huang J, Li W, Yi P, Yi M et al (2021) Identification of the protective effect of Polygonatum sibiricum polysaccharide on d-galactose-induced brain ageing in mice by the systematic characterization of a circular RNA-associated ceRNA network. Pharm Biol 59(1):347\u2013366","journal-title":"Pharm Biol"},{"key":"5654_CR24","doi-asserted-by":"crossref","unstructured":"Guo H, Li M, Liu H (2022) Selenium-Rich Yeast Peptide Fraction Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis in Mice by Inhibiting Inflammation via MAPK and NF-\u03baB Signaling Pathways. Int J Mol Sci 23(4)","DOI":"10.3390\/ijms23042112"},{"issue":"4","key":"5654_CR25","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.it.2012.11.005","volume":"34","author":"MA Lowes","year":"2013","unstructured":"Lowes MA, Russell CB, Martin DA, Towne JE, Krueger JG (2013) The IL-23\/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses. Trends Immunol 34(4):174\u2013181","journal-title":"Trends Immunol"},{"key":"5654_CR26","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3899\/jrheum.200124","volume":"96","author":"LC Coates","year":"2020","unstructured":"Coates LC, Merola JF, Grieb SM, Mease PJ, Callis Duffin K (2020) Methotrexate in Psoriasis and Psoriatic Arthritis. J Rheumatol Suppl 96:31\u201335","journal-title":"J Rheumatol Suppl"},{"issue":"7","key":"5654_CR27","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.ad.2010.04.002","volume":"101","author":"G Carretero","year":"2010","unstructured":"Carretero G, Puig L, Dehesa L, Carrascosa JM, Ribera M, Sanchez-Regana M et al (2010) Guidelines on the Use of Methotrexate in Psoriasis. Actas Dermosifiliogr 101(7):600\u2013613","journal-title":"Actas Dermosifiliogr"},{"issue":"3","key":"5654_CR28","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1007\/s10787-023-01178-0","volume":"31","author":"OY Elkhawaga","year":"2023","unstructured":"Elkhawaga OY, Ellety MM, Mofty SO, Ghanem MS, Mohamed AO (2023) Review of natural compounds for potential psoriasis treatment. Inflammopharmacology 31(3):1183\u20131198","journal-title":"Inflammopharmacology"},{"key":"5654_CR29","doi-asserted-by":"crossref","unstructured":"Lee YG, Jung Y, Choi HK, Lee JI, Lim TG, Lee J (2024) Natural Product-Derived Compounds Targeting Keratinocytes and Molecular Pathways in Psoriasis Therapeutics. Int J Mol Sci 25(11)","DOI":"10.3390\/ijms25116068"},{"issue":"1","key":"5654_CR30","first-page":"60","volume":"158","author":"T Fredriksson","year":"1979","unstructured":"Fredriksson T, Pettersson U (1979) Oral treatment of pustulosis palmo-plantaris with a new retinoid, Ro 10-9359. Dermatologica 158(1):60\u201364","journal-title":"Dermatologica"},{"issue":"11","key":"5654_CR31","doi-asserted-by":"publisher","first-page":"3395","DOI":"10.7150\/ijbs.83141","volume":"19","author":"Y Luo","year":"2023","unstructured":"Luo Y, Pang B, Hao J, Li Q, Qiao P, Zhang C et al (2023) Keratin 17 covalently binds to alpha-enolase and exacerbates proliferation of keratinocytes in psoriasis. Int J Biol Sci 19(11):3395\u20133411","journal-title":"Int J Biol Sci"},{"issue":"7","key":"5654_CR32","doi-asserted-by":"publisher","first-page":"e40797","DOI":"10.1371\/journal.pone.0040797","volume":"7","author":"W Zhang","year":"2012","unstructured":"Zhang W, Dang E, Shi X, Jin L, Feng Z, Hu L et al (2012) The pro-inflammatory cytokine IL-22 up-regulates keratin 17 expression in keratinocytes via STAT3 and ERK1\/2. PLoS ONE 7(7):e40797","journal-title":"PLoS ONE"},{"issue":"1","key":"5654_CR33","doi-asserted-by":"publisher","first-page":"14738","DOI":"10.1038\/s41598-022-18900-7","volume":"12","author":"H Shinno-Hashimoto","year":"2022","unstructured":"Shinno-Hashimoto H, Eguchi A, Sakamoto A, Wan X, Hashimoto Y, Fujita Y et al (2022) Effects of splenectomy on skin inflammation and psoriasis-like phenotype of imiquimod-treated mice. Sci Rep 12(1):14738","journal-title":"Sci Rep"},{"issue":"6","key":"5654_CR34","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1111\/apm.13221","volume":"130","author":"DV Lopez","year":"2022","unstructured":"Lopez DV, Kongsbak-Wismann M (2022) Role of IL-22 in homeostasis and diseases of the skin. APMIS 130(6):314\u2013322","journal-title":"APMIS"},{"key":"5654_CR35","doi-asserted-by":"publisher","first-page":"596086","DOI":"10.3389\/fimmu.2020.596086","volume":"11","author":"M Vecellio","year":"2020","unstructured":"Vecellio M, Hake VX, Davidson C, Carena MC, Wordsworth BP, Selmi C (2020) The IL-17\/IL-23 Axis and Its Genetic Contribution to Psoriatic Arthritis. Front Immunol 11:596086","journal-title":"Front Immunol"},{"issue":"6","key":"5654_CR36","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s11926-007-0075-1","volume":"9","author":"E Fitch","year":"2007","unstructured":"Fitch E, Harper E, Skorcheva I, Kurtz SE, Blauvelt A (2007) Pathophysiology of psoriasis: recent advances on IL-23 and Th17 cytokines. Curr Rheumatol Rep 9(6):461\u2013467","journal-title":"Curr Rheumatol Rep"},{"key":"5654_CR37","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1590\/1678-4162-12583","volume":"74","author":"T Su","year":"2022","unstructured":"Su T, Liu F, Kou C-X, Liu H-B, Xu S-J, Zhang D-Y et al (2022) Caracter\u00edstica da diminui\u00e7\u00e3o da diversidade bacteriana na psor\u00edase. Arquivo Brasileiro de Med Veterin\u00e1ria e Zootecnia 74:767\u2013777","journal-title":"Arquivo Brasileiro de Med Veterin\u00e1ria e Zootecnia"},{"issue":"1","key":"5654_CR38","doi-asserted-by":"publisher","first-page":"11265","DOI":"10.1038\/s41598-021-90480-4","volume":"11","author":"H Shinno-Hashimoto","year":"2021","unstructured":"Shinno-Hashimoto H, Hashimoto Y, Wei Y, Chang L, Fujita Y, Ishima T et al (2021) Abnormal composition of microbiota in the gut and skin of imiquimod-treated mice. Sci Rep 11(1):11265","journal-title":"Sci Rep"},{"issue":"7","key":"5654_CR39","doi-asserted-by":"publisher","first-page":"111191","DOI":"10.1016\/j.celrep.2022.111191","volume":"40","author":"GV Pinget","year":"2022","unstructured":"Pinget GV, Tan JK, Ni D, Taitz J, Daien CI, Mielle J et al (2022) Dysbiosis in imiquimod-induced psoriasis alters gut immunity and exacerbates colitis development. Cell Rep 40(7):111191","journal-title":"Cell Rep"},{"issue":"7","key":"5654_CR40","first-page":"adv00512","volume":"101","author":"T Todberg","year":"2021","unstructured":"Todberg T, Kaiser H, Zachariae C, Egeberg A, Halling AS, Skov L (2021) Characterization of the Oral and Gut Microbiota in Patients with Psoriatic Diseases: A Systematic Review. Acta dermato-venereologica 101(7):adv00512","journal-title":"Acta dermato-venereologica"},{"key":"5654_CR41","doi-asserted-by":"crossref","unstructured":"Chen X, Chen Y, Stanton C, Ross RP, Zhao J, Chen W et al (2023) Dose-Response Efficacy and Mechanisms of Orally Administered Bifidobacterium breve CCFM683 on IMQ-Induced Psoriasis in Mice. Nutrients 15(8)","DOI":"10.3390\/nu15081952"},{"key":"5654_CR42","doi-asserted-by":"publisher","first-page":"571319","DOI":"10.3389\/fimmu.2020.571319","volume":"11","author":"S Yegorov","year":"2020","unstructured":"Yegorov S, Babenko D, Kozhakhmetov S, Akhmaltdinova L, Kadyrova I, Nurgozhina A et al (2020) Psoriasis Is Associated With Elevated Gut IL-1alpha and Intestinal Microbiome Alterations. Front Immunol 11:571319","journal-title":"Front Immunol"},{"key":"5654_CR43","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.3389\/fmicb.2018.01021","volume":"9","author":"IA Rather","year":"2018","unstructured":"Rather IA, Bajpai VK, Huh YS, Han YK, Bhat EA, Lim J et al (2018) Probiotic Lactobacillus sakei proBio-65 Extract Ameliorates the Severity of Imiquimod Induced Psoriasis-Like Skin Inflammation in a Mouse Model. Front Microbiol 9:1021","journal-title":"Front Microbiol"},{"key":"5654_CR44","doi-asserted-by":"publisher","first-page":"1227309","DOI":"10.3389\/fmicb.2023.1227309","volume":"14","author":"X Du","year":"2023","unstructured":"Du X, Yan C, Kong S, Che D, Peng B, Zhu L et al (2023) Successful secukinumab therapy in plaque psoriasis is associated with altered gut microbiota and related functional changes. Front Microbiol 14:1227309","journal-title":"Front Microbiol"},{"issue":"1","key":"5654_CR45","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1038\/s41392-022-01219-0","volume":"8","author":"Q Zhao","year":"2023","unstructured":"Zhao Q, Yu J, Zhou H, Wang X, Zhang C, Hu J et al (2023) Intestinal dysbiosis exacerbates the pathogenesis of psoriasis-like phenotype through changes in fatty acid metabolism. Signal Transduct Target Ther 8(1):40","journal-title":"Signal Transduct Target Ther"},{"issue":"6","key":"5654_CR46","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1111\/bjd.17931","volume":"181","author":"C Hidalgo-Cantabrana","year":"2019","unstructured":"Hidalgo-Cantabrana C, Gomez J, Delgado S, Requena-Lopez S, Queiro-Silva R, Margolles A et al (2019) Gut microbiota dysbiosis in a cohort of patients with psoriasis. Br J Dermatol 181(6):1287\u20131295","journal-title":"Br J Dermatol"},{"issue":"3","key":"5654_CR47","doi-asserted-by":"publisher","first-page":"pbad023","DOI":"10.1093\/pcmedi\/pbad023","volume":"6","author":"N Yu","year":"2023","unstructured":"Yu N, Wang J, Liu Y, Guo Y (2023) Investigating the gut microbiota\u2019s influence on psoriasis and psoriatic arthritis risk: a Mendelian randomization analysis. Precis Clin Med 6(3):pbad023","journal-title":"Precis Clin Med"},{"key":"5654_CR48","doi-asserted-by":"publisher","first-page":"1344963","DOI":"10.3389\/fimmu.2024.1344963","volume":"15","author":"H Zhao","year":"2024","unstructured":"Zhao H, Shang L, Zhang Y, Liang Z, Wang N, Zhang Q et al (2024) IL-17A inhibitors alleviate Psoriasis with concomitant restoration of intestinal\/skin microbiota homeostasis and altered microbiota function. Front Immunol 15:1344963","journal-title":"Front Immunol"},{"key":"5654_CR49","doi-asserted-by":"publisher","first-page":"20134","DOI":"10.1038\/srep20134","volume":"6","author":"L Grine","year":"2016","unstructured":"Grine L, Steeland S, Van Ryckeghem S, Ballegeer M, Lienenklaus S, Weiss S et al (2016) Topical imiquimod yields systemic effects due to unintended oral uptake. Sci Rep 6:20134","journal-title":"Sci Rep"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-026-05654-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-026-05654-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-026-05654-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:04:37Z","timestamp":1791245077000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-026-05654-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,24]]},"references-count":49,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["5654"],"URL":"https:\/\/doi.org\/10.1007\/s11010-026-05654-3","relation":{},"ISSN":["1573-4919"],"issn-type":[{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,24]]},"assertion":[{"value":"8 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were designed, conducted, and reported in accordance with the ARRIVE guidelines and were approved by the Animal Ethics Committee of Hunan University of Chinese Medicine (approval no. 2023-KY-048).","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}}]}}