{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:56:10Z","timestamp":1791186970341,"version":"4.1.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"DOI":"10.1007\/s11010-026-05678-9","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T08:57:34Z","timestamp":1785401854000},"page":"4381-4393","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Schisandrin B alleviates osteoporosis by regulating gut microbiota homeostasis"],"prefix":"10.1007","volume":"481","author":[{"given":"Hongming","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longyang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songlin","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chonghui","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"issue":"1","key":"5678_CR1","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/prd.12422","volume":"89","author":"B Yu","year":"2022","unstructured":"Yu B, Wang CY (2022) Osteoporosis and periodontal diseases - An update on their association and mechanistic links. Periodontol 2000 89(1):99\u2013113","journal-title":"Periodontol 2000"},{"issue":"4","key":"5678_CR2","doi-asserted-by":"publisher","first-page":"159","DOI":"10.11622\/smedj.2021036","volume":"62","author":"EL Yong","year":"2021","unstructured":"Yong EL, Logan S (2021) Menopausal osteoporosis: screening, prevention and treatment. Singap Med J 62(4):159\u2013166","journal-title":"Singap Med J"},{"issue":"4","key":"5678_CR3","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.ecl.2024.08.008","volume":"53","author":"P Subarajan","year":"2024","unstructured":"Subarajan P, Arceo-Mendoza RM, Camacho PM (2024) Postmenopausal osteoporosis: a review of latest guidelines. Endocrinol Metab Clin North Am 53(4):497\u2013512","journal-title":"Endocrinol Metab Clin North Am"},{"key":"5678_CR4","doi-asserted-by":"publisher","DOI":"10.1177\/17455057231176655","volume":"19","author":"U Amin","year":"2023","unstructured":"Amin U, McPartland A, O\u2019Sullivan M, Silke C (2023) An overview of the management of osteoporosis in the aging female population. Womens Health (Lond) 19:17455057231176655","journal-title":"Womens Health (Lond)"},{"key":"5678_CR5","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.965258","volume":"13","author":"W Zhang","year":"2022","unstructured":"Zhang W, Gao R, Rong X, Zhu S, Cui Y, Liu H, Li M (2022) Immunoporosis: role of immune system in the pathophysiology of different types of osteoporosis. Front Endocrinol (Lausanne) 13:965258","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"11","key":"5678_CR6","doi-asserted-by":"publisher","first-page":"2466","DOI":"10.1007\/s11427-023-2346-1","volume":"66","author":"L Fan","year":"2023","unstructured":"Fan L, Xia Y, Wang Y, Han D et al (2023) Gut microbiota bridges dietary nutrients and host immunity. Sci China Life Sci 66(11):2466\u20132514","journal-title":"Sci China Life Sci"},{"issue":"13","key":"5678_CR7","doi-asserted-by":"publisher","first-page":"3509","DOI":"10.1080\/10408398.2020.1867054","volume":"62","author":"Z Ling","year":"2022","unstructured":"Ling Z, Liu X, Cheng Y, Yan X, Wu S (2022) Gut microbiota and aging. Crit Rev Food Sci Nutr 62(13):3509\u20133534","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"7","key":"5678_CR8","doi-asserted-by":"publisher","first-page":"e21740","DOI":"10.1096\/fj.202100451R","volume":"35","author":"L Lu","year":"2021","unstructured":"Lu L, Chen X, Liu Y, Yu X (2021) Gut microbiota and bone metabolism. FASEB J 35(7):e21740","journal-title":"FASEB J"},{"issue":"20","key":"5678_CR9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2306776121","volume":"121","author":"J Chen","year":"2024","unstructured":"Chen J, Liu X, Zou Y, Gong J, Ge Z, Lin X, Zhang W, Huang H, Zhao J, Saw PE, Lu Y, Hu H, Song E (2024) A high-fat diet promotes cancer progression by inducing gut microbiota-mediated leucine production and PMN-MDSC differentiation. Proc Natl Acad Sci U S A 121(20):e2306776121","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"5678_CR10","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1016\/j.cmet.2024.04.004","volume":"36","author":"D Wang","year":"2024","unstructured":"Wang D, Cai J, Pei Q, Yan Z, Zhu F, Zhao Z, Liu R, Guo X, Sun T, Liu J, Tian Y, Liu H, Shao X, Huang J, Hao X, Chang Q, Luo Z, Jing D (2024) Gut microbial alterations in arginine metabolism determine bone mechanical adaptation. Cell Metab 36(6):1252\u20131268e8","journal-title":"Cell Metab"},{"issue":"1","key":"5678_CR11","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2437247","volume":"17","author":"XQ Zheng","year":"2025","unstructured":"Zheng XQ, Wang DB, Jiang YR, Song CL (2025) Gut microbiota and microbial metabolites for osteoporosis. Gut Microbes 17(1):2437247","journal-title":"Gut Microbes"},{"key":"5678_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2023.106930","volume":"196","author":"Z Guan","year":"2023","unstructured":"Guan Z, Xuanqi Z, Zhu J, Yuan W, Jia J, Zhang C, Sun T, Leng H, Jiang C, Xu Y, Song C (2023) Estrogen deficiency induces bone loss through the gut microbiota. Pharmacol Res 196:106930","journal-title":"Pharmacol Res"},{"key":"5678_CR13","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c07332","author":"Y Zheng","year":"2024","unstructured":"Zheng Y, Zhang Z, Fu Z, Fan A, Song N, Wang Q, Fan S, Xu J, Xiang J, Liu X (2024) Oral propolis nanoemulsions modulate gut microbiota to balance bone remodeling for enhanced osteoporosis therapy. ACS Nano. https:\/\/doi.org\/10.1021\/acsnano.4c07332","journal-title":"ACS Nano"},{"issue":"6","key":"5678_CR14","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.14336\/AD.2023.0425","volume":"14","author":"JDH Waldbaum","year":"2023","unstructured":"Waldbaum JDH, Xhumari J, Akinsuyi OS, Arjmandi B, Anton S, Roesch LFW (2023) Association between dysbiosis in the gut microbiota of primary osteoporosis patients and bone loss. Aging Dis 14(6):2081\u20132095","journal-title":"Aging Dis"},{"issue":"1","key":"5678_CR15","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1186\/s12906-022-03713-y","volume":"22","author":"A Gholami","year":"2022","unstructured":"Gholami A, Dabbaghmanesh MH, Ghasemi Y, Koohpeyma F, Talezadeh P, Montazeri-Najafabady N (2022) The ameliorative role of specific probiotic combinations on bone loss in the ovariectomized rat model. BMC Complement Med Ther 22(1):241","journal-title":"BMC Complement Med Ther"},{"issue":"4","key":"5678_CR16","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1111\/jre.13256","volume":"59","author":"RL Lucateli","year":"2024","unstructured":"Lucateli RL, Silva PHF, Salvador SL, Ervolino E, Furlaneto FAC, Marciano MA, Antunes TBM, Del Arco MCG, Tardelli MDC, de Sousa LG, Messora MR (2024) Probiotics enhance alveolar bone microarchitecture, intestinal morphology and estradiol levels in osteoporotic animals. J Periodontal Res 59(4):758\u2013770","journal-title":"J Periodontal Res"},{"issue":"1","key":"5678_CR17","doi-asserted-by":"publisher","first-page":"9689","DOI":"10.1038\/s41598-024-60061-2","volume":"14","author":"F Goudarzi","year":"2024","unstructured":"Goudarzi F, Kiani A, Nami Y, Shahmohammadi A, Mohammadalipour A, Karami A, Haghshenas B (2024) Potential probiotic Lactobacillus delbrueckii subsp. lactis KUMS-Y33 suppresses adipogenesis and promotes osteogenesis in human adipose-derived mesenchymal stem cell. Sci Rep 14(1):9689","journal-title":"Sci Rep"},{"key":"5678_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1528533","volume":"16","author":"Y Fang","year":"2025","unstructured":"Fang Y, Pan J, Wang P, Wang R, Liang S (2025) A comprehensive review of Schisandrin B\u2019s preclinical antitumor activity and mechanistic insights from network pharmacology. Front Pharmacol 16:1528533","journal-title":"Front Pharmacol"},{"key":"5678_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.156672","volume":"141","author":"C Xu","year":"2025","unstructured":"Xu C, Wang H, Wang H, Man J, Deng Y, Li Y, Cheng K, Niu J, Gui H, Fu S, Yang L (2025) Schisandrin B regulates mitochondrial dynamics via AKT1 activation and mitochondrial targeting to ameliorate renal ischemia-reperfusion injury. Phytomedicine 141:156672","journal-title":"Phytomedicine"},{"issue":"2","key":"5678_CR20","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s00232-025-00340-9","volume":"258","author":"F Hu","year":"2025","unstructured":"Hu F, Tong S, Xu H (2025) Schisandrin B improves mitochondrial function and inhibits HT22 cell apoptosis by regulating Sirt3 protein. J Membr Biol 258(2):123\u2013133","journal-title":"J Membr Biol"},{"issue":"1\u20132","key":"5678_CR21","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s00232-023-00299-5","volume":"257","author":"F Hu","year":"2024","unstructured":"Hu F, Hu W, Xu H (2024) Schisandrin B alleviates LPS induced mitochondrial damage in C28I2 cells. J Membr Biol 257(1\u20132):107\u2013114","journal-title":"J Membr Biol"},{"key":"5678_CR22","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.01175","volume":"11","author":"J Wang","year":"2020","unstructured":"Wang J, Fang Z, Song C, Kang H, Guo Q, Dong Y, Zhang Y, Peng R, Guan H, Li F (2020) Schisandrin B inhibits osteoclastogenesis and protects against ovariectomy-induced bone loss. Front Pharmacol 11:1175","journal-title":"Front Pharmacol"},{"issue":"5","key":"5678_CR23","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.5114\/aoms.2020.92873","volume":"19","author":"Y Liang","year":"2020","unstructured":"Liang Y, Li W, Li X, Nan J (2020) Involvement of PI3K\/Akt\/\u03b2-catenin signaling in schisandrin B-mitigated bone deterioration in an experimental rat model of estrogen deficiency. Arch Med Sci 19(5):1520\u20131529","journal-title":"Arch Med Sci"},{"key":"5678_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1497311","volume":"15","author":"P Qi","year":"2024","unstructured":"Qi P, Xie R, Liu H, Zhang Z, Cheng Y, Ma J, Wan K, Xie X (2024) Mechanisms of gut homeostasis regulating Th17\/Treg cell balance in PMOP. Front Immunol 15:1497311","journal-title":"Front Immunol"},{"key":"5678_CR25","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1611932","volume":"16","author":"J Luo","year":"2025","unstructured":"Luo J, Li L, Shi W, Xu K, Shen Y, Dai B (2025) Oxidative stress and inflammation: roles in osteoporosis. Front Immunol 16:1611932","journal-title":"Front Immunol"},{"issue":"4","key":"5678_CR26","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.bbrc.2010.10.103","volume":"402","author":"K Bandow","year":"2010","unstructured":"Bandow K, Maeda A, Kakimoto K, Kusuyama J, Shamoto M, Ohnishi T, Matsuguchi T (2010) Molecular mechanisms of the inhibitory effect of lipopolysaccharide (LPS) on osteoblast differentiation. Biochem Biophys Res Commun 402(4):755\u2013761","journal-title":"Biochem Biophys Res Commun"},{"key":"5678_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2022.152036","volume":"246","author":"Z Lu","year":"2023","unstructured":"Lu Z, Zhang A, Dai Y (2023) CX3CL1 deficiency ameliorates inflammation, apoptosis and accelerates osteogenic differentiation, mineralization in LPS-treated MC3T3-E1 cells via its receptor CX3CR1. Ann Anat 246:152036","journal-title":"Ann Anat"},{"key":"5678_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2025.103025","volume":"96","author":"P Chen","year":"2025","unstructured":"Chen P, Lin J (2025) Bushen Jiangu decoction alleviates osteoporosis by inhibiting MMP2 expression and activation of the MAPK pathway in vitro. Tissue Cell 96:103025","journal-title":"Tissue Cell"},{"issue":"10","key":"5678_CR29","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202600092RR","volume":"40","author":"X Jiang","year":"2026","unstructured":"Jiang X, Jia W, Ma Q, Fan W, Luo S (2026) MMP14 silencing alleviates inflammation-associated bone loss in chronic periodontitis and postmenopausal osteoporosis in association with reduced JAK2\/STAT3 signaling. FASEB J 40(10):e71899","journal-title":"FASEB J"},{"issue":"2","key":"5678_CR30","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.ecl.2021.03.009","volume":"50","author":"RM Arceo-Mendoza","year":"2021","unstructured":"Arceo-Mendoza RM, Camacho PM (2021) Postmenopausal osteoporosis: latest guidelines. Endocrinol Metab Clin North Am 50(2):167\u2013178","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"2","key":"5678_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.108912","volume":"27","author":"M Jin","year":"2024","unstructured":"Jin M, Yi X, Zhu X, Hu W, Wang S, Chen Q, Yang W, Li Y, Li S, Peng Q, Pan M, Gao Y, Xu S, Zhang Y, Zhou S (2024) Schisandrin B promotes hepatic differentiation from human umbilical cord mesenchymal stem cells. iScience 27(2):108912","journal-title":"iScience"},{"key":"5678_CR32","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.733992","volume":"12","author":"P Qiu","year":"2022","unstructured":"Qiu P, Ishimoto T, Fu L, Zhang J, Zhang Z, Liu Y (2022) The gut microbiota in inflammatory bowel disease. Front Cell Infect Microbiol 12:733992","journal-title":"Front Cell Infect Microbiol"},{"key":"5678_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113810","volume":"155","author":"PJ Ma","year":"2022","unstructured":"Ma PJ, Wang MM, Wang Y (2022) Gut microbiota: a new insight into lung diseases. Biomed Pharmacother 155:113810","journal-title":"Biomed Pharmacother"},{"issue":"8","key":"5678_CR34","doi-asserted-by":"publisher","DOI":"10.3390\/nu15081880","volume":"15","author":"DE Radford-Smith","year":"2023","unstructured":"Radford-Smith DE, Anthony DC (2023) Prebiotic and probiotic modulation of the microbiota-gut-brain axis in depression. Nutrients 15(8):1880","journal-title":"Nutrients"},{"key":"5678_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112341","volume":"136","author":"R Feng","year":"2024","unstructured":"Feng R, Wang Q, Yu T, Hu H, Wu G, Duan X, Jiang R, Xu Y, Huang Y (2024) Quercetin ameliorates bone loss in OVX rats by modulating the intestinal flora-SCFAs-inflammatory signaling axis. Int Immunopharmacol 136:112341","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"5678_CR36","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2236749","volume":"15","author":"S Hu","year":"2023","unstructured":"Hu S, Ding Q, Zhang W, Kang M, Ma J, Zhao L (2023) Gut microbial beta-glucuronidase: a vital regulator in female estrogen metabolism. Gut Microbes 15(1):2236749","journal-title":"Gut Microbes"},{"key":"5678_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106355","volume":"182","author":"W Guo","year":"2022","unstructured":"Guo W, Zhang Z, Li L, Liang X, Wu Y, Wang X, Ma H, Cheng J, Zhang A, Tang P, Wang CZ, Wan JY, Yao H, Yuan CS (2022) Gut microbiota induces DNA methylation via SCFAs predisposing obesity-prone individuals to diabetes. Pharmacol Res 182:106355","journal-title":"Pharmacol Res"},{"issue":"1","key":"5678_CR38","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/s41420-025-02633-3","volume":"11","author":"HT Hu","year":"2025","unstructured":"Hu HT, Zhang ZY, Luo Z-, Ti HB, Wu JJ, Nie H, Yuan ZD, Wu X, Zhang KY, Shi SW, Qian YQ, Wang XC, Wu JJ, Li X, Yuan FL (2025) Emerging regulated cell death mechanisms in bone remodeling: decoding ferroptosis, cuproptosis, disulfidptosis, and PANoptosis as therapeutic targets for skeletal disorders. Cell Death Discov 11(1):335","journal-title":"Cell Death Discov"},{"key":"5678_CR39","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S606941","author":"Y Liang","year":"2026","unstructured":"Liang Y, Wang K, Yang C, Huang J, Huang Z, Chen Y (2026) Pathogenesis of osteoarthritis: mechanisms of action of disulfidptosis and targeted therapeutic strategies. Drug Des Devel Ther. https:\/\/doi.org\/10.2147\/DDDT.S606941","journal-title":"Drug Des Devel Ther"},{"issue":"4","key":"5678_CR40","doi-asserted-by":"publisher","DOI":"10.36922\/OR025450032","volume":"1","author":"Y Yang","year":"2025","unstructured":"Yang Y, Wang YB, Yin H et al (2025) Organoids in aging research: decoding mechanisms, accelerating interventions, and bridging translation. Organoid Research 1(4):025450032","journal-title":"Organoid Research"},{"issue":"4","key":"5678_CR41","first-page":"270","volume":"4","author":"S Deng","year":"2023","unstructured":"Deng S, Zhu F, Dai K, Wang J, Liu C (2023) Harvest of functional mesenchymal stem cells derived from in vivo osteo-organoids. Biomater Transl 4(4):270\u2013279","journal-title":"Biomater Transl"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-026-05678-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-026-05678-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-026-05678-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:45:22Z","timestamp":1791186322000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-026-05678-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,30]]},"references-count":41,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["5678"],"URL":"https:\/\/doi.org\/10.1007\/s11010-026-05678-9","relation":{},"ISSN":["1573-4919"],"issn-type":[{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,30]]},"assertion":[{"value":"22 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The animal experimental protocol was approved by the Animal Ethics Committee of Ningbo University (Approval No. 13263) and strictly followed international guidelines for ethical animal research.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}]}}