{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:56:06Z","timestamp":1791186966959,"version":"4.1.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004480","name":"Natural Science Foundation of Shanxi Province","doi-asserted-by":"publisher","award":["202403021212281"],"award-info":[{"award-number":["202403021212281"]}],"id":[{"id":"10.13039\/501100004480","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772914"],"award-info":[{"award-number":["81772914"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2019A1515010963"],"award-info":[{"award-number":["2019A1515010963"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"DOI":"10.1007\/s11010-026-05682-z","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T09:08:04Z","timestamp":1786612084000},"page":"4753-4770","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["LINP1 suppresses radiation-induced cellular senescence in keratinocytes by modulating the mTOR\u2013p53 axis"],"prefix":"10.1007","volume":"481","author":[{"given":"Xiaoting","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minfei","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaru","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"issue":"4420","key":"5682_CR1","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1126\/science.493980","volume":"206","author":"C Morgan","year":"1979","unstructured":"Morgan C (1979) Ionizing radiation study. Science 206(4420):769\u2013769. https:\/\/doi.org\/10.1126\/science.493980","journal-title":"Science"},{"key":"5682_CR2","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/1748-717x-6-32","volume":"6","author":"R Huber","year":"2011","unstructured":"Huber R, Braselmann H, Geinitz H, Jaehnert I, Baumgartner A, Thamm R, Figel M, Molls M, Zitzelsberger H (2011) Chromosomal radiosensitivity and acute radiation side effects after radiotherapy in tumour patients\u2013a follow-up study. Radiat Oncol 6:32. https:\/\/doi.org\/10.1186\/1748-717x-6-32","journal-title":"Radiat Oncol"},{"issue":"20","key":"5682_CR3","doi-asserted-by":"publisher","first-page":"e2203387","DOI":"10.1002\/adhm.202203387","volume":"12","author":"Y Hao","year":"2023","unstructured":"Hao Y, Li H, Guo J, Wang D, Zhang J, Liu J, Yang C, Zhang Y, Li G, Liu J (2023) Bio-inspired antioxidant heparin-mimetic peptide hydrogel for radiation-induced skin injury repair. Adv Healthc Mater 12(20):e2203387. https:\/\/doi.org\/10.1002\/adhm.202203387","journal-title":"Adv Healthc Mater"},{"issue":"1","key":"5682_CR4","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.1038\/s41467-019-10386-8","volume":"10","author":"Z Wang","year":"2019","unstructured":"Wang Z, Chen Z, Jiang Z, Luo P, Liu L, Huang Y, Wang H, Wang Y, Long L, Tan X et al (2019) Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents. Nat Commun 10(1):2538. https:\/\/doi.org\/10.1038\/s41467-019-10386-8","journal-title":"Nat Commun"},{"issue":"6","key":"5682_CR5","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.tcb.2018.02.001","volume":"28","author":"A Hernandez-Segura","year":"2018","unstructured":"Hernandez-Segura A, Nehme J, Demaria M (2018) Hallmarks of cellular senescence. Trends Cell Biol 28(6):436\u2013453. https:\/\/doi.org\/10.1016\/j.tcb.2018.02.001","journal-title":"Trends Cell Biol"},{"issue":"2","key":"5682_CR6","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","volume":"186","author":"C L\u00f3pez-Ot\u00edn","year":"2023","unstructured":"L\u00f3pez-Ot\u00edn C, Blasco MA, Partridge L, Serrano M, Kroemer G (2023) Hallmarks of aging: an expanding universe. Cell 186(2):243\u2013278. https:\/\/doi.org\/10.1016\/j.cell.2022.11.001","journal-title":"Cell"},{"issue":"1","key":"5682_CR7","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1083\/jcb.201708092","volume":"217","author":"D McHugh","year":"2018","unstructured":"McHugh D, Gil J (2018) Senescence and aging: causes, consequences, and therapeutic avenues. J Cell Biol 217(1):65\u201377. https:\/\/doi.org\/10.1083\/jcb.201708092","journal-title":"J Cell Biol"},{"issue":"12","key":"5682_CR8","doi-asserted-by":"publisher","first-page":"2288","DOI":"10.1093\/neuonc\/noae153","volume":"26","author":"N Luo","year":"2024","unstructured":"Luo N, Zhu W, Li X, Fu M, Zhang Y, Yang F, Zhang Y, Chen Z, Zhang Q, Peng B et al (2024) Defective autophagy of pericytes enhances radiation-induced senescence promoting radiation brain injury. Neuro Oncol 26(12):2288\u20132304. https:\/\/doi.org\/10.1093\/neuonc\/noae153","journal-title":"Neuro Oncol"},{"issue":"15","key":"5682_CR9","doi-asserted-by":"publisher","first-page":"e2304609","DOI":"10.1002\/advs.202304609","volume":"11","author":"J Ji","year":"2024","unstructured":"Ji J, Ding K, Cheng B, Zhang X, Luo T, Huang B, Yu H, Chen Y, Xu X, Lin H et al (2024) Radiotherapy-induced astrocyte senescence promotes an immunosuppressive microenvironment in glioblastoma to facilitate tumor regrowth. Adv Sci (Weinh) 11(15):e2304609. https:\/\/doi.org\/10.1002\/advs.202304609","journal-title":"Adv Sci (Weinh)"},{"key":"5682_CR10","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20232136","author":"M Reimann","year":"2024","unstructured":"Reimann M, Lee S, Schmitt CA (2024) Cellular senescence: neither irreversible nor reversible. J Exp Med221(4):e20232136 https:\/\/doi.org\/10.1084\/jem.20232136","journal-title":"J Exp Med"},{"issue":"12","key":"5682_CR11","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1038\/s41580-024-00727-x","volume":"25","author":"B Wang","year":"2024","unstructured":"Wang B, Han J, Elisseeff JH, Demaria M (2024) The senescence-associated secretory phenotype and its physiological and pathological implications. Nat Rev Mol Cell Biol 25(12):958\u2013978. https:\/\/doi.org\/10.1038\/s41580-024-00727-x","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"9","key":"5682_CR12","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1038\/s41419-022-05229-2","volume":"13","author":"L Gong","year":"2022","unstructured":"Gong L, Cui D, Liu D, Shen X, Pan H, Xiong X, Zhao Y (2022) FBXW7 inactivation induces cellular senescence via accumulation of p53. Cell Death Dis 13(9):788. https:\/\/doi.org\/10.1038\/s41419-022-05229-2","journal-title":"Cell Death Dis"},{"key":"5682_CR13","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.semcancer.2024.05.001","volume":"101","author":"Y Huang","year":"2024","unstructured":"Huang Y, Che X, Wang PW, Qu X (2024) p53\/MDM2 signaling pathway in aging, senescence and tumorigenesis. Semin Cancer Biol 101:44\u201357. https:\/\/doi.org\/10.1016\/j.semcancer.2024.05.001","journal-title":"Semin Cancer Biol"},{"key":"5682_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/biom10030420","author":"M Mijit","year":"2020","unstructured":"Mijit M, Caracciolo V, Melillo A, Amicarelli F, Giordano A (2020) Role of p53 in the regulation of cellular senescence. Biomolecules 10(3):420. https:\/\/doi.org\/10.3390\/biom10030420","journal-title":"Biomolecules"},{"issue":"1","key":"5682_CR15","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.cmet.2020.05.002","volume":"32","author":"L Grosse","year":"2020","unstructured":"Grosse L, Wagner N, Emelyanov A, Molina C, Lacas-Gervais S, Wagner KD, Bulavin DV (2020) Defined p16(High) senescent cell types are indispensable for mouse healthspan. Cell Metab 32(1):87\u201399. https:\/\/doi.org\/10.1016\/j.cmet.2020.05.002","journal-title":"Cell Metab"},{"issue":"6","key":"5682_CR16","doi-asserted-by":"publisher","first-page":"151108","DOI":"10.1016\/j.ejcb.2020.151108","volume":"99","author":"NS Mohamad Kamal","year":"2020","unstructured":"Mohamad Kamal NS, Safuan S, Shamsuddin S, Foroozandeh P (2020) Aging of the cells: insight into cellular senescence and detection methods. Eur J Cell Biol 99(6):151108. https:\/\/doi.org\/10.1016\/j.ejcb.2020.151108","journal-title":"Eur J Cell Biol"},{"key":"5682_CR17","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23158390","author":"M Park","year":"2022","unstructured":"Park M, Na J, Kwak SY, Park S, Kim H, Lee SJ, Jang WS, Lee SB, Jang WI, Jang H et al (2022) Zileuton alleviates radiation-induced cutaneous ulcers via inhibition of senescence-associated secretory phenotype in rodents. Int J Mol Sci 23(15):8390. https:\/\/doi.org\/10.3390\/ijms23158390","journal-title":"Int J Mol Sci"},{"issue":"23","key":"5682_CR18","doi-asserted-by":"publisher","first-page":"4394","DOI":"10.1016\/j.cell.2022.10.004","volume":"185","author":"MS Heltberg","year":"2022","unstructured":"Heltberg MS, Lucchetti A, Hsieh FS, Minh Nguyen DP, Chen SH, Jensen MH (2022) Enhanced DNA repair through droplet formation and p53 oscillations. Cell 185(23):4394\u20134408. https:\/\/doi.org\/10.1016\/j.cell.2022.10.004","journal-title":"Cell"},{"issue":"1","key":"5682_CR19","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/nrm3025","volume":"12","author":"R Zoncu","year":"2011","unstructured":"Zoncu R, Efeyan A, Sabatini DM (2011) mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 12(1):21\u201335. https:\/\/doi.org\/10.1038\/nrm3025","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"10","key":"5682_CR20","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1038\/s41388-018-0521-8","volume":"38","author":"SH Jung","year":"2019","unstructured":"Jung SH, Hwang HJ, Kang D, Park HA, Lee HC, Jeong D, Lee K, Park HJ, Ko YG, Lee JS (2019) mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53. Oncogene 38(10):1639\u20131650. https:\/\/doi.org\/10.1038\/s41388-018-0521-8","journal-title":"Oncogene"},{"issue":"5","key":"5682_CR21","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/s41580-023-00694-9","volume":"25","author":"J Ferrer","year":"2024","unstructured":"Ferrer J, Dimitrova N (2024) Transcription regulation by long non-coding RNAs: mechanisms and disease relevance. Nat Rev Mol Cell Biol 25(5):396\u2013415. https:\/\/doi.org\/10.1038\/s41580-023-00694-9","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"6","key":"5682_CR22","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/s41580-021-00447-6","volume":"23","author":"T Nojima","year":"2022","unstructured":"Nojima T, Proudfoot NJ (2022) Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics. Nat Rev Mol Cell Biol 23(6):389\u2013406. https:\/\/doi.org\/10.1038\/s41580-021-00447-6","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"12","key":"5682_CR23","doi-asserted-by":"publisher","first-page":"2252","DOI":"10.1016\/j.molcel.2022.05.027","volume":"82","author":"AB Herman","year":"2022","unstructured":"Herman AB, Tsitsipatis D, Gorospe M (2022) Integrated lncRNA function upon genomic and epigenomic regulation. Mol Cell 82(12):2252\u20132266. https:\/\/doi.org\/10.1016\/j.molcel.2022.05.027","journal-title":"Mol Cell"},{"issue":"6","key":"5682_CR24","doi-asserted-by":"publisher","first-page":"3089","DOI":"10.1093\/nar\/gkaa063","volume":"48","author":"CL Xu","year":"2020","unstructured":"Xu CL, Sang B, Liu GZ, Li JM, Zhang XD, Liu LX, Thorne RF, Wu M (2020) SENEBLOC, a long non-coding RNA suppresses senescence via p53-dependent and independent mechanisms. Nucleic Acids Res 48(6):3089\u20133102. https:\/\/doi.org\/10.1093\/nar\/gkaa063","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"5682_CR25","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1186\/s13046-024-03233-2","volume":"43","author":"J Kallenbach","year":"2024","unstructured":"Kallenbach J, Rasa M, Heidari Horestani M, Atri Roozbahani G, Schindler K, Baniahmad A (2024) The oncogenic lncRNA MIR503HG suppresses cellular senescence counteracting supraphysiological androgen treatment in prostate cancer. J Exp Clin Cancer Res 43(1):321. https:\/\/doi.org\/10.1186\/s13046-024-03233-2","journal-title":"J Exp Clin Cancer Res"},{"issue":"9","key":"5682_CR26","doi-asserted-by":"publisher","first-page":"e1418","DOI":"10.1002\/ctm2.1418","volume":"13","author":"D Chen","year":"2023","unstructured":"Chen D, Wang J, Li Y, Xu C, Fanzheng M, Zhang P, Liu L (2023) LncRNA NEAT1 suppresses cellular senescence in hepatocellular carcinoma via KIF11-dependent repression of CDKN2A. Clin Transl Med 13(9):e1418. https:\/\/doi.org\/10.1002\/ctm2.1418","journal-title":"Clin Transl Med"},{"issue":"1","key":"5682_CR27","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s12951-020-00716-0","volume":"18","author":"L Zhuang","year":"2020","unstructured":"Zhuang L, Xia W, Chen D, Ye Y, Hu T, Li S, Hou M (2020) Exosomal LncRNA-NEAT1 derived from MIF-treated mesenchymal stem cells protected against doxorubicin-induced cardiac senescence through sponging miR-221-3p. J Nanobiotechnol 18(1):157. https:\/\/doi.org\/10.1186\/s12951-020-00716-0","journal-title":"J Nanobiotechnol"},{"key":"5682_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2024.117506","author":"X Cheng","year":"2024","unstructured":"Cheng X, Shihabudeen Haider Ali MS, Baki VB, Moran M, Su H, Sun X (2024) Multifaceted roles of Meg3 in cellular senescence and atherosclerosis. Atherosclerosis 392:117506. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2024.117506","journal-title":"Atherosclerosis"},{"issue":"6","key":"5682_CR29","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1038\/nsmb.3211","volume":"23","author":"Y Zhang","year":"2016","unstructured":"Zhang Y, He Q, Hu Z, Feng Y, Fan L, Tang Z, Yuan J, Shan W, Li C, Hu X et al (2016) Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer. Nat Struct Mol Biol 23(6):522\u2013530. https:\/\/doi.org\/10.1038\/nsmb.3211","journal-title":"Nat Struct Mol Biol"},{"key":"5682_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25063320","author":"CE R\u00fcbe","year":"2024","unstructured":"R\u00fcbe CE, Freyter BM, Tewary G, Roemer K, Hecht M, R\u00fcbe C (2024) Radiation dermatitis: radiation-induced effects on the structural and immunological barrier function of the epidermis. Int J Mol Sci 25(6):3320. https:\/\/doi.org\/10.3390\/ijms25063320","journal-title":"Int J Mol Sci"},{"key":"5682_CR31","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.198692","author":"C Dodson","year":"2026","unstructured":"Dodson C, Bilik SM, DiBartolomeo G, Pachalis H, Siegfried LG, Johnson JAK, Thaller SR, Pastar I, Tomic-Canic M, Griswold AJ et al (2026) A human ex vivo model of radiation-induced skin injury recapitulates p53-driven pro-fibrotic response to radiotherapy. JCI Insight 11(13):e198692. https:\/\/doi.org\/10.1172\/jci.insight.198692","journal-title":"JCI Insight https\/\/"},{"issue":"1","key":"5682_CR32","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1021\/acs.accounts.1c00544","volume":"55","author":"Y Eygeris","year":"2022","unstructured":"Eygeris Y, Gupta M, Kim J, Sahay G (2022) Chemistry of lipid nanoparticles for RNA delivery. Acc Chem Res 55(1):2\u201312. https:\/\/doi.org\/10.1021\/acs.accounts.1c00544","journal-title":"Acc Chem Res"},{"issue":"2","key":"5682_CR33","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.ymthe.2024.01.005","volume":"32","author":"M Moazzam","year":"2024","unstructured":"Moazzam M, Zhang M, Hussain A, Yu X, Huang J, Huang Y (2024) The landscape of nanoparticle-based siRNA delivery and therapeutic development. Mol Ther 32(2):284\u2013312. https:\/\/doi.org\/10.1016\/j.ymthe.2024.01.005","journal-title":"Mol Ther"},{"key":"5682_CR34","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.jconrel.2024.08.030","volume":"375","author":"PS Wei","year":"2024","unstructured":"Wei PS, Thota N, John G, Chang E, Lee S, Wang Y, Ma Z, Tsai YH, Mei KC (2024) Enhancing RNA-lipid nanoparticle delivery: Organ- and cell-specificity and barcoding strategies. J Control Release 375:366\u2013388. https:\/\/doi.org\/10.1016\/j.jconrel.2024.08.030","journal-title":"J Control Release"},{"issue":"20","key":"5682_CR35","doi-asserted-by":"publisher","first-page":"12181","DOI":"10.1021\/acs.chemrev.1c00244","volume":"121","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Sun C, Wang C, Jankovic KE, Dong Y (2021) Lipids and lipid derivatives for RNA delivery. Chem Rev 121(20):12181\u201312277. https:\/\/doi.org\/10.1021\/acs.chemrev.1c00244","journal-title":"Chem Rev"},{"issue":"2","key":"5682_CR36","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1080\/15384047.2017.1394543","volume":"19","author":"Y Liang","year":"2018","unstructured":"Liang Y, Li Y, Song X, Zhang N, Sang Y, Zhang H, Liu Y, Chen B, Zhao W, Wang L et al (2018) Long noncoding RNA LINP1 acts as an oncogene and promotes chemoresistance in breast cancer. Cancer Biol Ther 19(2):120\u2013131. https:\/\/doi.org\/10.1080\/15384047.2017.1394543","journal-title":"Cancer Biol Ther"},{"issue":"1","key":"5682_CR37","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s40164-023-00395-1","volume":"12","author":"X Liang","year":"2023","unstructured":"Liang X, Liu J, Liu X, Jin Y, Xu M, Han Z, Wang K, Zhang C, Zou F, Zhou L (2023) LINP1 represses unfolded protein response by directly inhibiting eIF2\u03b1 phosphorylation to promote cutaneous squamous cell carcinoma. Exp Hematol Oncol 12(1):31. https:\/\/doi.org\/10.1186\/s40164-023-00395-1","journal-title":"Exp Hematol Oncol"},{"key":"5682_CR38","doi-asserted-by":"publisher","first-page":"109536","DOI":"10.1016\/j.cellsig.2020.109536","volume":"68","author":"T Ma","year":"2020","unstructured":"Ma T, Liang Y, Li Y, Song X, Zhang N, Li X, Chen B, Zhao W, Wang L, Yang Q (2020) LncRNA LINP1 confers tamoxifen resistance and negatively regulated by ER signaling in breast cancer. Cell Signal 68:109536. https:\/\/doi.org\/10.1016\/j.cellsig.2020.109536","journal-title":"Cell Signal"},{"issue":"4","key":"5682_CR39","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1002\/hon.2651","volume":"37","author":"J Shi","year":"2019","unstructured":"Shi J, Dai R, Chen Y, Guo H, Han Y, Zhang Y (2019) LncRNA LINP1 regulates acute myeloid leukemia progression via HNF4\u03b1\/AMPK\/WNT5A signaling pathway. Hematol Oncol 37(4):474\u2013482. https:\/\/doi.org\/10.1002\/hon.2651","journal-title":"Hematol Oncol"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-026-05682-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-026-05682-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-026-05682-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:45:17Z","timestamp":1791186317000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-026-05682-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":39,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["5682"],"URL":"https:\/\/doi.org\/10.1007\/s11010-026-05682-z","relation":{},"ISSN":["1573-4919"],"issn-type":[{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,13]]},"assertion":[{"value":"21 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The protocol procedure for foreskin collection was approved by the Ethics Committee of Shanxi Medical University Medical (Approval No. 2025034).","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Human foreskin samples were obtained from surgical discards following routine circumcision, with written informed consent from all donors or their parents. All procedures were conducted in accordance with the Declaration of Helsinki.","order":3,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Declarations"}}]}}