{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:19:38Z","timestamp":1792783178604,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Fujian Provincial Natural Science Foundation","award":["2024J011268"],"award-info":[{"award-number":["2024J011268"]}],"id":[{"id":"https:\/\/ror.org\/04aqat463","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Fuzhou Science and Technology Project","award":["2025-S-020"],"award-info":[{"award-number":["2025-S-020"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"DOI":"10.1007\/s11010-026-05694-9","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T08:10:42Z","timestamp":1786954242000},"page":"4829-4842","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Erastin-sensitive VDAC2 contributes to time-course peritoneal fibrosis via ferroptosis signaling induction"],"prefix":"10.1007","volume":"481","author":[{"given":"Wenfeng","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangping","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"issue":"Suppl 1","key":"5694_CR1","doi-asserted-by":"publisher","first-page":"s37","DOI":"10.1590\/1806-9282.66.S1.37","volume":"66","author":"MCC Andreoli","year":"2020","unstructured":"Andreoli MCC, Totoli C (2020) Peritoneal dialysis. Rev Assoc Med Bras (1992) 66(Suppl 1):s37\u2013s44. https:\/\/doi.org\/10.1590\/1806-9282.66.S1.37","journal-title":"Rev Assoc Med Bras (1992)"},{"key":"5694_CR2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1220450","volume":"14","author":"J Li","year":"2023","unstructured":"Li J, Liu Y, Liu J (2023) A review of research progress on mechanisms of peritoneal fibrosis related to peritoneal dialysis. Front Physiol 14:1220450. https:\/\/doi.org\/10.3389\/fphys.2023.1220450","journal-title":"Front Physiol"},{"key":"5694_CR3","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.607204","volume":"12","author":"M Terri","year":"2021","unstructured":"Terri M, Trionfetti F, Montaldo C, Cordani M, Tripodi M, Lopez-Cabrera M, Strippoli R (2021) Mechanisms of peritoneal fibrosis: focus on immune cells-peritoneal stroma interactions. Front Immunol 12:607204. https:\/\/doi.org\/10.3389\/fimmu.2021.607204","journal-title":"Front Immunol"},{"key":"5694_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2020.109778","volume":"75","author":"MS Balzer","year":"2020","unstructured":"Balzer MS (2020) Molecular pathways in peritoneal fibrosis. Cell Signal 75:109778. https:\/\/doi.org\/10.1016\/j.cellsig.2020.109778","journal-title":"Cell Signal"},{"key":"5694_CR5","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B, Stockwell BR (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149:1060\u20131072. https:\/\/doi.org\/10.1016\/j.cell.2012.03.042","journal-title":"Cell"},{"key":"5694_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.109812","volume":"116","author":"X Huang","year":"2023","unstructured":"Huang X, Song Y, Wei L, Guo J, Xu W, Li M (2023) The emerging roles of ferroptosis in organ fibrosis and its potential therapeutic effect. Int Immunopharmacol 116:109812. https:\/\/doi.org\/10.1016\/j.intimp.2023.109812","journal-title":"Int Immunopharmacol"},{"key":"5694_CR7","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1097\/CM9.0000000000002784","volume":"137","author":"X Qiu","year":"2024","unstructured":"Qiu X, Bi Q, Wu J, Sun Z, Wang W (2024) Role of ferroptosis in fibrosis: From mechanism to potential therapy. Chin Med J (Engl) 137:806\u2013817. https:\/\/doi.org\/10.1097\/CM9.0000000000002784","journal-title":"Chin Med J (Engl)"},{"key":"5694_CR8","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1038\/nature05859","volume":"447","author":"N Yagoda","year":"2007","unstructured":"Yagoda N, von Rechenberg M, Zaganjor E, Bauer AJ, Yang WS, Fridman DJ, Wolpaw AJ, Smukste I, Peltier JM, Boniface JJ, Smith R, Lessnick SL, Sahasrabudhe S, Stockwell BR (2007) RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature 447:864\u20138. https:\/\/doi.org\/10.1038\/nature05859","journal-title":"Nature"},{"key":"5694_CR9","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1111\/j.1523-1755.2004.00491.x","volume":"65","author":"HB Lee","year":"2004","unstructured":"Lee HB, Yu MR, Song JS, Ha H (2004) Reactive oxygen species amplify protein kinase C signaling in high glucose-induced fibronectin expression by human peritoneal mesothelial cells. Kidney Int 65:1170\u20131179. https:\/\/doi.org\/10.1111\/j.1523-1755.2004.00491.x","journal-title":"Kidney Int"},{"key":"5694_CR10","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","volume":"171","author":"BR Stockwell","year":"2017","unstructured":"Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascon S, Hatzios SK, Kagan VE, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat GC, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti FM, Torti SV, Toyokuni S, Woerpel KA, Zhang DD (2017) Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease. Cell 171:273\u2013285. https:\/\/doi.org\/10.1016\/j.cell.2017.09.021","journal-title":"Cell"},{"key":"5694_CR11","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","volume":"22","author":"X Jiang","year":"2021","unstructured":"Jiang X, Stockwell BR, Conrad M (2021) Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol 22:266\u2013282. https:\/\/doi.org\/10.1038\/s41580-020-00324-8","journal-title":"Nat Rev Mol Cell Biol"},{"key":"5694_CR12","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aav5341","author":"M Si","year":"2019","unstructured":"Si M, Wang Q, Li Y, Lin H, Luo D, Zhao W, Dou X, Liu J, Zhang H, Huang Y, Lou T, Hu Z, Peng H (2019) Inhibition of hyperglycolysis in mesothelial cells prevents peritoneal fibrosis. Sci Transl Med. https:\/\/doi.org\/10.1126\/scitranslmed.aav5341","journal-title":"Sci Transl Med"},{"key":"5694_CR13","doi-asserted-by":"publisher","first-page":"101297","DOI":"10.1016\/j.redox.2019.101297","volume":"26","author":"Z Li","year":"2019","unstructured":"Li Z, Jiang L, Chew SH, Hirayama T, Sekido Y, Toyokuni S (2019) Carbonic anhydrase 9 confers resistance to ferroptosis\/apoptosis in malignant mesothelioma under hypoxia. Redox Biol 26:101297. https:\/\/doi.org\/10.1016\/j.redox.2019.101297","journal-title":"Redox Biol"},{"key":"5694_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17243983","author":"T Sato","year":"2025","unstructured":"Sato T, Hasegawa I, Ikeda H, Ohshiro T, Kondo-Ida L, Mukai S, Ohte S, Maeda T, Sekido Y (2025) Epithelioid mesothelioma cells exhibit increased ferroptosis sensitivity compared to non-epithelioid mesothelioma cells. Cancers (Basel). https:\/\/doi.org\/10.3390\/cancers17243983","journal-title":"Cancers (Basel)"},{"key":"5694_CR15","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1177\/1091581815591223","volume":"35","author":"M Yu","year":"2016","unstructured":"Yu M, Chen R, Jia Z, Chen J, Lou J, Tang S, Zhang X (2016) MWCNTs Induce ROS Generation, ERK Phosphorylation, and SOD-2 Expression in Human Mesothelial Cells. Int J Toxicol 35:17\u201326. https:\/\/doi.org\/10.1177\/1091581815591223","journal-title":"Int J Toxicol"},{"key":"5694_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21114158","author":"RB Wilson","year":"2020","unstructured":"Wilson RB, Archid R, Reymond MA (2020) Reprogramming of mesothelial-mesenchymal transition in chronic peritoneal diseases by estrogen receptor modulation and TGF-beta1 inhibition. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms21114158","journal-title":"Int J Mol Sci"},{"key":"5694_CR17","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1186\/s12967-023-04470-3","volume":"21","author":"T Zhao","year":"2023","unstructured":"Zhao T, Sun Z, Lai X, Lu H, Liu L, Li S, Yuan JH, Guo Z (2023) Tamoxifen exerts anti-peritoneal fibrosis effects by inhibiting H19-activated VEGFA transcription. J Transl Med 21:614. https:\/\/doi.org\/10.1186\/s12967-023-04470-3","journal-title":"J Transl Med"},{"key":"5694_CR18","doi-asserted-by":"publisher","DOI":"10.3892\/or.2021.7976","author":"Y Yang","year":"2021","unstructured":"Yang Y, Liu T, Hu C, Xia H, Liu W, Chen J, Wu S, Jiang Y, Xu Y, Liu W, Zhao L (2021) Ferroptosis inducer erastin downregulates androgen receptor and its splice variants in castration\u2011resistant prostate cancer. Oncol Rep. https:\/\/doi.org\/10.3892\/or.2021.7976","journal-title":"Oncol Rep"},{"key":"5694_CR19","doi-asserted-by":"publisher","first-page":"123","DOI":"10.18054\/pb.v125i1-2.25293","volume":"125","author":"E Duman\u010di\u0107","year":"2023","unstructured":"Duman\u010di\u0107 E, Vojta L, Fulgosi H (2023) Beginners guide to sample preparation techniques for transmission electron microscopy. Period Biol 125:123\u2013131","journal-title":"Period Biol"},{"key":"5694_CR20","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2026.1726566","volume":"17","author":"S Chen","year":"2026","unstructured":"Chen S, Cheng Y, Li W, Zhao Y (2026) Ferroptosis: unveiling a transformative perspective in the landscape of autoimmune diseases. Front Immunol 17:1726566. https:\/\/doi.org\/10.3389\/fimmu.2026.1726566","journal-title":"Front Immunol"},{"key":"5694_CR21","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","volume":"11","author":"J Li","year":"2020","unstructured":"Li J, Cao F, Yin HL, Huang ZJ, Lin ZT, Mao N, Sun B, Wang G (2020) Ferroptosis: past, present and future. Cell Death Dis 11:88. https:\/\/doi.org\/10.1038\/s41419-020-2298-2","journal-title":"Cell Death Dis"},{"key":"5694_CR22","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/s41420-022-01297-7","volume":"8","author":"Y Du","year":"2022","unstructured":"Du Y, Guo Z (2022) Recent progress in ferroptosis: inducers and inhibitors. Cell Death Discov 8:501. https:\/\/doi.org\/10.1038\/s41420-022-01297-7","journal-title":"Cell Death Discov"},{"key":"5694_CR23","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1016\/j.bbrc.2016.08.124","volume":"478","author":"H Yuan","year":"2016","unstructured":"Yuan H, Li X, Zhang X, Kang R, Tang D (2016) Identification of ACSL4 as a biomarker and contributor of ferroptosis. Biochem Biophys Res Commun 478:1338\u20131343. https:\/\/doi.org\/10.1016\/j.bbrc.2016.08.124","journal-title":"Biochem Biophys Res Commun"},{"key":"5694_CR24","doi-asserted-by":"publisher","first-page":"2521","DOI":"10.1097\/CM9.0000000000002533","volume":"136","author":"K Ding","year":"2023","unstructured":"Ding K, Liu C, Li L, Yang M, Jiang N, Luo S, Sun L (2023) Acyl-CoA synthase ACSL4: an essential target in ferroptosis and fatty acid metabolism. Chin Med J (Engl) 136:2521\u20132537. https:\/\/doi.org\/10.1097\/CM9.0000000000002533","journal-title":"Chin Med J (Engl)"},{"key":"5694_CR25","doi-asserted-by":"publisher","first-page":"2688","DOI":"10.21037\/tcr-21-2157","volume":"11","author":"N Guo","year":"2022","unstructured":"Guo N (2022) Identification of ACSL4 as a biomarker and contributor of ferroptosis in clear cell renal cell carcinoma. Transl Cancer Res 11:2688\u20132699. https:\/\/doi.org\/10.21037\/tcr-21-2157","journal-title":"Transl Cancer Res"},{"key":"5694_CR26","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.amjms.2023.04.024","volume":"366","author":"Z Sun","year":"2023","unstructured":"Sun Z, Zou X, Bao M, Huang Z, Lou Y, Zhang Y, Huang P (2023) Role of ferroptosis in fibrosis diseases. Am J Med Sci 366:87\u201395. https:\/\/doi.org\/10.1016\/j.amjms.2023.04.024","journal-title":"Am J Med Sci"},{"key":"5694_CR27","doi-asserted-by":"publisher","first-page":"2862","DOI":"10.1111\/bph.15952","volume":"180","author":"M Hao","year":"2023","unstructured":"Hao M, Han X, Yao Z, Zhang H, Zhao M, Peng M, Wang K, Shan Q, Sang X, Wu X, Wang L, Lv Q, Yang Q, Bao Y, Kuang H, Zhang H, Cao G (2023) The pathogenesis of organ fibrosis: Focus on necroptosis. Br J Pharmacol 180:2862\u20132879. https:\/\/doi.org\/10.1111\/bph.15952","journal-title":"Br J Pharmacol"},{"key":"5694_CR28","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/s41419-021-04137-1","volume":"12","author":"B Zhang","year":"2021","unstructured":"Zhang B, Chen X, Ru F, Gan Y, Li B, Xia W, Dai G, He Y, Chen Z (2021) Liproxstatin-1 attenuates unilateral ureteral obstruction-induced renal fibrosis by inhibiting renal tubular epithelial cells ferroptosis. Cell Death Dis 12:843. https:\/\/doi.org\/10.1038\/s41419-021-04137-1","journal-title":"Cell Death Dis"},{"key":"5694_CR29","doi-asserted-by":"publisher","first-page":"102509","DOI":"10.1016\/j.redox.2022.102509","volume":"57","author":"Z Pei","year":"2022","unstructured":"Pei Z, Qin Y, Fu X, Yang F, Huo F, Liang X, Wang S, Cui H, Lin P, Zhou G, Yan J, Wu J, Chen ZN, Zhu P (2022) Inhibition of ferroptosis and iron accumulation alleviates pulmonary fibrosis in a bleomycin model. Redox Biol 57:102509. https:\/\/doi.org\/10.1016\/j.redox.2022.102509","journal-title":"Redox Biol"},{"key":"5694_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2024.116845","volume":"484","author":"Q Yuan","year":"2024","unstructured":"Yuan Q, Fang Y, Guo J, Zhang Z, Liao J, Kuang J (2024) Therapeutic potential and mechanisms of Rifaximin in ameliorating iron overload-induced ferroptosis and liver fibrosis in vivo and in vitro. Toxicol Appl Pharmacol 484:116845. https:\/\/doi.org\/10.1016\/j.taap.2024.116845","journal-title":"Toxicol Appl Pharmacol"},{"key":"5694_CR31","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.freeradbiomed.2022.01.020","volume":"181","author":"Z Zhang","year":"2022","unstructured":"Zhang Z, Tang J, Song J, Xie M, Liu Y, Dong Z, Liu X, Li X, Zhang M, Chen Y, Shi H, Zhong J (2022) Elabela alleviates ferroptosis, myocardial remodeling, fibrosis and heart dysfunction in hypertensive mice by modulating the IL-6\/STAT3\/GPX4 signaling. Free Radic Biol Med 181:130\u2013142. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2022.01.020","journal-title":"Free Radic Biol Med"},{"key":"5694_CR32","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1056\/NEJMoa020809","volume":"348","author":"M Yanez-Mo","year":"2003","unstructured":"Yanez-Mo M, Lara-Pezzi E, Selgas R, Ramirez-Huesca M, Dominguez-Jimenez C, Jimenez-Heffernan JA, Aguilera A, Sanchez-Tomero JA, Bajo MA, Alvarez V, Castro MA, del Peso G, Cirujeda A, Gamallo C, Sanchez-Madrid F, Lopez-Cabrera M (2003) Peritoneal dialysis and epithelial-to-mesenchymal transition of mesothelial cells. N Engl J Med 348:403\u201313. https:\/\/doi.org\/10.1056\/NEJMoa020809","journal-title":"N Engl J Med"},{"key":"5694_CR33","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/263285","volume":"2013","author":"J Loureiro","year":"2013","unstructured":"Loureiro J, Gonzalez-Mateo G, Jimenez-Heffernan J, Selgas R, Lopez-Cabrera M, Aguilera Peralta A (2013) Are the mesothelial-to-mesenchymal transition, sclerotic peritonitis syndromes, and encapsulating peritoneal sclerosis part of the same process? Int J Nephrol 2013:263285. https:\/\/doi.org\/10.1155\/2013\/263285","journal-title":"Int J Nephrol"},{"key":"5694_CR34","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002598","author":"G Del Peso","year":"2008","unstructured":"Del Peso G, Jimenez-Heffernan JA, Bajo MA, Aroeira LS, Aguilera A, Fernandez-Perpen A, Cirugeda A, Castro MJ, de Gracia R, Sanchez-Villanueva R, Sanchez-Tomero JA, Lopez-Cabrera M, Selgas R (2008) Epithelial-to-mesenchymal transition of mesothelial cells is an early event during peritoneal dialysis and is associated with high peritoneal transport. Kidney Int Suppl:S. https:\/\/doi.org\/10.1038\/sj.ki.5002598","journal-title":"Kidney Int Suppl:S"},{"key":"5694_CR35","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1681\/ASN.2006111292","volume":"18","author":"LS Aroeira","year":"2007","unstructured":"Aroeira LS, Aguilera A, Sanchez-Tomero JA, Bajo MA, del Peso G, Jimenez-Heffernan JA, Selgas R, Lopez-Cabrera M (2007) Epithelial to mesenchymal transition and peritoneal membrane failure in peritoneal dialysis patients: pathologic significance and potential therapeutic interventions. J Am Soc Nephrol 18:2004\u201313. https:\/\/doi.org\/10.1681\/ASN.2006111292","journal-title":"J Am Soc Nephrol"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-026-05694-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-026-05694-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-026-05694-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:45:26Z","timestamp":1791186326000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-026-05694-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,17]]},"references-count":35,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["5694"],"URL":"https:\/\/doi.org\/10.1007\/s11010-026-05694-9","relation":{},"ISSN":["1573-4919"],"issn-type":[{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,17]]},"assertion":[{"value":"27 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of Fuzhou Cold-Spring Biology Co.,LTD (Approval number: IACUCBWS-2025043003) and conducted in accordance with relevant guidelines and regulations.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}]}}