{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:55:50Z","timestamp":1791186950224,"version":"4.1.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Anhui Provincial Health Science and Technology Project","award":["AHWJ2024BAi30011"],"award-info":[{"award-number":["AHWJ2024BAi30011"]}]},{"name":"Clinical and Translational Research Project of Anhui Province","award":["202427b10020062"],"award-info":[{"award-number":["202427b10020062"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"DOI":"10.1007\/s11010-026-05702-y","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T09:18:12Z","timestamp":1787217492000},"page":"4887-4899","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["ADAMDEC-1 promotes atherosclerosis progression by interacting with ACTN4 and modulating the PTEN-PI3K\/AKT signaling axis"],"prefix":"10.1007","volume":"481","author":[{"given":"Yanmei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengwei","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianxin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"issue":"5","key":"5702_CR1","doi-asserted-by":"publisher","first-page":"5683","DOI":"10.1021\/acsomega.3c08147","volume":"9","author":"KX Hao","year":"2024","unstructured":"Hao KX et al (2024) Comparative activities of three compounds from Citrus aurantium L. var. amara Engl. to improve oxidized low-density lipoprotein-induced lipid deposition. ACS Omega 9(5):5683\u20135694","journal-title":"ACS Omega"},{"issue":"7855","key":"5702_CR2","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/s41586-021-03392-8","volume":"592","author":"P Libby","year":"2021","unstructured":"Libby P (2021) The changing landscape of atherosclerosis. Nature 592(7855):524\u2013533","journal-title":"Nature"},{"key":"5702_CR3","doi-asserted-by":"publisher","first-page":"5141","DOI":"10.2147\/JIR.S375759","volume":"15","author":"M Ma","year":"2022","unstructured":"Ma M et al (2022) Relationship between monocyte-to-lymphocyte ratio as well as other leukocyte-derived ratios and carotid plaques in patients with coronary heart disease: a RCSCD-TCM study. J Inflamm Res 15:5141\u20135156","journal-title":"J Inflamm Res"},{"issue":"D1","key":"5702_CR4","doi-asserted-by":"publisher","first-page":"D1348","DOI":"10.1093\/nar\/gkae848","volume":"53","author":"Q Qian","year":"2025","unstructured":"Qian Q et al (2025) CVD Atlas: a multi-omics database of cardiovascular disease. Nucleic Acids Res 53(D1):D1348-d1355","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"5702_CR5","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1161\/ATVBAHA.116.308682","volume":"37","author":"A Nicolaou","year":"2017","unstructured":"Nicolaou A et al (2017) Adam17 deficiency promotes atherosclerosis by enhanced TNFR2 signaling in mice. Arterioscler Thromb Vasc Biol 37(2):247\u2013257","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"5702_CR6","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.atherosclerosis.2019.03.008","volume":"286","author":"D Schick","year":"2019","unstructured":"Schick D et al (2019) Elevated expression of the metalloproteinase ADAM8 associates with vascular diseases in mice and humans. Atherosclerosis 286:163\u2013171","journal-title":"Atherosclerosis"},{"key":"5702_CR7","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.atherosclerosis.2019.02.002","volume":"283","author":"SM Zhang","year":"2019","unstructured":"Zhang SM et al (2019) A disintegrin and metalloprotease 22 accelerates neointima formation by activating ERK signaling. Atherosclerosis 283:92\u201399","journal-title":"Atherosclerosis"},{"issue":"13","key":"5702_CR8","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1093\/cvr\/cvy167","volume":"114","author":"X Yang","year":"2018","unstructured":"Yang X et al (2018) A disintegrin and metalloproteinase 15-mediated glycocalyx shedding contributes to vascular leakage during inflammation. Cardiovasc Res 114(13):1752\u20131763","journal-title":"Cardiovasc Res"},{"issue":"8","key":"5702_CR9","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1161\/CIRCRESAHA.123.322737","volume":"133","author":"MA Sharifi","year":"2023","unstructured":"Sharifi MA et al (2023) ADAMTS-7 modulates atherosclerotic plaque formation by degradation of TIMP-1. Circ Res 133(8):674\u2013686","journal-title":"Circ Res"},{"issue":"1","key":"5702_CR10","doi-asserted-by":"publisher","DOI":"10.1007\/s10142-023-01278-8","volume":"24","author":"X Wang","year":"2023","unstructured":"Wang X et al (2023) Knockdown of ADAMDEC1 ameliorates ox-LDL-induced endothelial cell injury and atherosclerosis progression. Funct Integr Genomics 24(1):1","journal-title":"Funct Integr Genomics"},{"issue":"1","key":"5702_CR11","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1080\/13880209.2021.2010775","volume":"60","author":"L Luo","year":"2022","unstructured":"Luo L et al (2022) Myristicin regulates proliferation and apoptosis in oxidized low-density lipoprotein-stimulated human vascular smooth muscle cells and human umbilical vein endothelial cells by regulating the PI3K\/Akt\/NF-\u03baB signalling pathway. Pharm Biol 60(1):56\u201364","journal-title":"Pharm Biol"},{"key":"5702_CR12","unstructured":"12. World Health Organization cardiovascular disease risk charts: revised models to estimate risk in 21 global regions. Lancet Glob Health, 2019. 7(10): p. e1332-e1345."},{"key":"5702_CR13","doi-asserted-by":"publisher","DOI":"10.1111\/eci.70167","author":"GO Gir\u00f3n","year":"2026","unstructured":"Gir\u00f3n GO et al (2026) Atherogenic dyslipidaemia and residual cardiovascular risk: understanding the link to heart disease. Eur J Clin Invest. https:\/\/doi.org\/10.1111\/eci.70167","journal-title":"Eur J Clin Invest"},{"issue":"2","key":"5702_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2023.113629","volume":"429","author":"Y Jia","year":"2023","unstructured":"Jia Y et al (2023) ADAMDEC1 induces EMT and promotes colorectal cancer cells metastasis by enhancing Wnt\/\u03b2-catenin signaling via negative modulation of GSK-3\u03b2. Exp Cell Res 429(2):113629","journal-title":"Exp Cell Res"},{"issue":"11","key":"5702_CR15","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1158\/2159-8290.CD-18-1308","volume":"9","author":"A Jimenez-Pascual","year":"2019","unstructured":"Jimenez-Pascual A et al (2019) ADAMDEC1 maintains a growth factor signaling loop in cancer stem cells. Cancer Discov 9(11):1574\u20131589","journal-title":"Cancer Discov"},{"issue":"12","key":"5702_CR16","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1093\/ecco-jcc\/jjw111","volume":"10","author":"NR O\u2019Shea","year":"2016","unstructured":"O\u2019Shea NR et al (2016) Critical role of the disintegrin metalloprotease ADAM-like Decysin-1 [ADAMDEC1] for intestinal immunity and inflammation. J Crohns Colitis 10(12):1417\u20131427","journal-title":"J Crohns Colitis"},{"issue":"1","key":"5702_CR17","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1080\/19420862.2017.1395541","volume":"10","author":"J Lund","year":"2018","unstructured":"Lund J et al (2018) Monoclonal antibodies targeting the disintegrin-like domain of ADAMDEC1 modulates the proteolytic activity and enables quantification of ADAMDEC1 protein in human plasma. MAbs 10(1):118\u2013128","journal-title":"MAbs"},{"issue":"11","key":"5702_CR18","doi-asserted-by":"publisher","first-page":"3636","DOI":"10.1111\/cas.16313","volume":"115","author":"H Nagata","year":"2024","unstructured":"Nagata H et al (2024) ACTN4 is associated with the malignant potential of thymic epithelial tumors through the \u03b2-catenin\/Slug pathway. Cancer Sci 115(11):3636\u20133647","journal-title":"Cancer Sci"},{"key":"5702_CR19","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.258581","author":"A Barai","year":"2021","unstructured":"Barai A et al (2021) \u03b1-Actinin-4 drives invasiveness by regulating myosin IIB expression and myosin IIA localization. J Cell Sci. https:\/\/doi.org\/10.1242\/jcs.258581","journal-title":"J Cell Sci"},{"issue":"4","key":"5702_CR20","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1007\/s13105-019-00700-9","volume":"75","author":"J Zhao","year":"2019","unstructured":"Zhao J et al (2019) Dysregulated expression of ACTN4 contributes to endothelial cell injury via the activation of the p38-MAPK\/p53 apoptosis pathway in preeclampsia. J Physiol Biochem 75(4):475\u2013487","journal-title":"J Physiol Biochem"},{"issue":"12","key":"5702_CR21","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1177\/1947601911407325","volume":"1","author":"MM Georgescu","year":"2010","unstructured":"Georgescu MM (2010) PTEN tumor suppressor network in PI3K-Akt pathway control. Genes Cancer 1(12):1170\u20137","journal-title":"Genes Cancer"},{"key":"5702_CR22","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.97228","author":"KS Moulton","year":"2018","unstructured":"Moulton KS et al (2018) PTEN deficiency promotes pathological vascular remodeling of human coronary arteries. JCI Insight. https:\/\/doi.org\/10.1172\/jci.insight.97228","journal-title":"JCI Insight"},{"issue":"1","key":"5702_CR23","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/s41401-025-01650-3","volume":"47","author":"JY Feng","year":"2026","unstructured":"Feng JY et al (2026) SOCS1 depletion drives osteosarcoma stemness and chemoresistance by suppressing ACTN4 degradation. Acta Pharmacol Sin 47(1):255\u2013271","journal-title":"Acta Pharmacol Sin"},{"issue":"15","key":"5702_CR24","doi-asserted-by":"publisher","first-page":"2736","DOI":"10.1038\/s41388-018-0621-5","volume":"38","author":"J Zhu","year":"2019","unstructured":"Zhu J et al (2019) Targeting TRIM3 deletion-induced tumor-associated lymphangiogenesis prohibits lymphatic metastasis in esophageal squamous cell carcinoma. Oncogene 38(15):2736\u20132749","journal-title":"Oncogene"},{"issue":"1","key":"5702_CR25","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.atherosclerosis.2009.12.006","volume":"210","author":"KA Volcik","year":"2010","unstructured":"Volcik KA et al (2010) MMP2 genetic variation is associated with measures of fibrous cap thickness: the Atherosclerosis Risk in Communities Carotid MRI Study. Atherosclerosis 210(1):188\u201393","journal-title":"Atherosclerosis"},{"key":"5702_CR26","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3872367","volume":"2020","author":"T Li","year":"2020","unstructured":"Li T et al (2020) The role of matrix metalloproteinase-9 in atherosclerotic plaque instability. Mediators Inflamm 2020:3872367","journal-title":"Mediators Inflamm"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-026-05702-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-026-05702-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-026-05702-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:45:28Z","timestamp":1791186328000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-026-05702-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,20]]},"references-count":26,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["5702"],"URL":"https:\/\/doi.org\/10.1007\/s11010-026-05702-y","relation":{},"ISSN":["1573-4919"],"issn-type":[{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,20]]},"assertion":[{"value":"1 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experiments were executed in strict adherence to the guidelines delineated in the Guide for the Care and Use of Laboratory Animals and received approval from the Animal Ethics Committee of Anhui Medical University (Approve number: LLSC202321). All participants signed informed consent forms, and conducted in strict accordance with the principles of the Declaration of Helsinki. The study protocol was approved by the Ethics Committee of the Second Affiliated Hospital of Anhui Medical University (Approval No.: YX2024-136).","order":2,"name":"Ethics","label":"Ethical approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}}]}}