{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T08:39:51Z","timestamp":1792571991693,"version":"4.5.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Internal Grant Agency of the Faculty of Medicine, Palacky University Olomouc","award":["IGA_LF_2026_009"],"award-info":[{"award-number":["IGA_LF_2026_009"]}]},{"name":"National Science Centre, Poland","award":["2020\/39\/I\/ST5\/00569"],"award-info":[{"award-number":["2020\/39\/I\/ST5\/00569"]}]},{"name":"Grant Agency of the Czech Republic","award":["21-45449L"],"award-info":[{"award-number":["21-45449L"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"DOI":"10.1007\/s11010-026-05728-2","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T08:41:07Z","timestamp":1788856867000},"page":"5355-5371","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In vitro evaluation of hydroxyapatite, \u03b2-tricalcium phosphate, graphene oxide and zinc oxide for osteochondral regeneration under inflammatory conditions"],"prefix":"10.1007","volume":"481","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4035-5543","authenticated-orcid":false,"given":"Roman","family":"Novotn\u00fd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1153-8677","authenticated-orcid":false,"given":"Izabella","family":"Rajzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9344-3569","authenticated-orcid":false,"given":"Jana","family":"Frankov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"5728_CR1","doi-asserted-by":"publisher","first-page":"30097","DOI":"10.1021\/acsomega.4c04789","volume":"9","author":"R Novotn\u00e1","year":"2024","unstructured":"Novotn\u00e1 R, Frankov\u00e1 J (2024) Materials suitable for osteochondral regeneration. ACS Omega 9:30097\u201330108. https:\/\/doi.org\/10.1021\/acsomega.4c04789","journal-title":"ACS Omega"},{"key":"5728_CR2","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.bioactmat.2023.04.016","volume":"27","author":"R Chen","year":"2023","unstructured":"Chen R, Pye JS, Li J et al (2023) Multiphasic scaffolds for the repair of osteochondral defects: Outcomes of preclinical studies. Bioact Mater 27:505\u2013545. https:\/\/doi.org\/10.1016\/j.bioactmat.2023.04.016","journal-title":"Bioact Mater"},{"key":"5728_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2024.111874","volume":"592","author":"K Campbell","year":"2024","unstructured":"Campbell K, Naire S, Kuiper JH (2024) A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation. J Theor Biol 592:111874. https:\/\/doi.org\/10.1016\/j.jtbi.2024.111874","journal-title":"J Theor Biol"},{"key":"5728_CR4","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1186\/s13018-025-06179-z","volume":"20","author":"BK Yilmaz","year":"2025","unstructured":"Yilmaz BK, Kaga S, Kaga E et al (2025) Evaluation of the efficacy of a double-layered and single-layered synthetic scaffold for the treatment of knee osteochondral defects - an experimental study. J Orthop Surg 20:744. https:\/\/doi.org\/10.1186\/s13018-025-06179-z","journal-title":"J Orthop Surg"},{"key":"5728_CR5","doi-asserted-by":"publisher","first-page":"6841","DOI":"10.1002\/jcb.27953","volume":"120","author":"T Zhang","year":"2019","unstructured":"Zhang T, Yao Y (2019) Effects of inflammatory cytokines on bone\/cartilage repair. J Cell Biochem 120:6841\u20136850. https:\/\/doi.org\/10.1002\/jcb.27953","journal-title":"J Cell Biochem"},{"key":"5728_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116786","volume":"234","author":"E-S Mehana","year":"2019","unstructured":"Mehana E-S, Khafaga AF, El-Blehi SS (2019) The role of matrix metalloproteinases in osteoarthritis pathogenesis: an updated review. Life Sci 234:116786. https:\/\/doi.org\/10.1016\/j.lfs.2019.116786","journal-title":"Life Sci"},{"key":"5728_CR7","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1016\/j.joca.2015.08.015","volume":"23","author":"J Lieberthal","year":"2015","unstructured":"Lieberthal J, Sambamurthy N, Scanzello CR (2015) Inflammation in joint injury and post-traumatic osteoarthritis. Osteoarthritis Cartilage 23:1825\u20131834. https:\/\/doi.org\/10.1016\/j.joca.2015.08.015","journal-title":"Osteoarthritis Cartilage"},{"key":"5728_CR8","doi-asserted-by":"publisher","first-page":"1754693","DOI":"10.3389\/fmed.2025.1754693","volume":"12","author":"B Liu","year":"2026","unstructured":"Liu B, Zhang M, Gao L, Yang H (2026) Targeting inflammation-metabolism crosstalk: current status and challenges of novel therapeutic strategies for osteoarthritis. Front Med 12:1754693. https:\/\/doi.org\/10.3389\/fmed.2025.1754693","journal-title":"Front Med"},{"key":"5728_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14248829","volume":"14","author":"YE Bulum","year":"2025","unstructured":"Bulum YE, Kara AB, Karata\u015f ME et al (2025) Prognostic role of lesion morphology in patellar osteochondral fixation: influence of localization and size on functional and pain outcomes. J Clin Med 14:8829. https:\/\/doi.org\/10.3390\/jcm14248829","journal-title":"J Clin Med"},{"key":"5728_CR10","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1177\/10711007251393253","volume":"47","author":"A Sabaghzadeh","year":"2026","unstructured":"Sabaghzadeh A, Zarei H, Jafari Kafiabadi M et al (2026) Osteochondral Autograft Transplant (Mosaicplasty) Without Debriding the Recipient Site in Osteochondral Lesions of the Talus: Clinical Outcomes of a Prospective Study. Foot Ankle Int 47:184\u2013193. https:\/\/doi.org\/10.1177\/10711007251393253","journal-title":"Foot Ankle Int"},{"key":"5728_CR11","doi-asserted-by":"publisher","DOI":"10.1002\/biot.202400699","volume":"20","author":"Z Wang","year":"2025","unstructured":"Wang Z, Xu J, Zhu J et al (2025) Osteochondral tissue engineering: scaffold materials, fabrication techniques and applications. Biotechnol J 20:e202400699. https:\/\/doi.org\/10.1002\/biot.202400699","journal-title":"Biotechnol J"},{"key":"5728_CR12","doi-asserted-by":"publisher","DOI":"10.3390\/polym18050614","volume":"18","author":"Y Tong","year":"2026","unstructured":"Tong Y, Cai Y, Wu Y et al (2026) From design to application: advanced cellulose scaffolds for engineered tissue regeneration. Polymers 18:614. https:\/\/doi.org\/10.3390\/polym18050614","journal-title":"Polymers"},{"key":"5728_CR13","doi-asserted-by":"publisher","first-page":"e03186","DOI":"10.1002\/adhm.202503186","volume":"15","author":"K Loukelis","year":"2026","unstructured":"Loukelis K, Kontogianni G, Arango-Ospina M et al (2026) 3D Bioprinted Constructs Enriched with Zinc\u2010Doped Bioactive Glass Promote Antibacterial Activity and Osteochondral Tissue Regeneration. Adv Healthc Mater 15:e03186. https:\/\/doi.org\/10.1002\/adhm.202503186","journal-title":"Adv Healthc Mater"},{"key":"5728_CR14","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2026.2638414","author":"\u015eB Yeni","year":"2026","unstructured":"Yeni \u015eB, Erarslan A, Ahlatc\u0131o\u011flu \u00d6zerol E (2026) Electrically active biomaterials for osteochondral tissue engineering: a review. J Biomater Sci Polym Ed. https:\/\/doi.org\/10.1080\/09205063.2026.2638414","journal-title":"J Biomater Sci Polym Ed"},{"key":"5728_CR15","doi-asserted-by":"publisher","DOI":"10.20517\/microstructures.2023.84","author":"Q-P Jia","year":"2024","unstructured":"Jia Q-P, Li Q, Boucetta H et al (2024) Biomimetic-smart materials for osteochondral regeneration and repair. Microstructures. https:\/\/doi.org\/10.20517\/microstructures.2023.84","journal-title":"Microstructures"},{"key":"5728_CR16","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.bioactmat.2022.12.015","volume":"24","author":"C Li","year":"2023","unstructured":"Li C, Sun F, Tian J et al (2023) Continuously released Zn2\u2009+\u2009in 3D-printed PLGA\/\u03b2-TCP\/Zn scaffolds for bone defect repair by improving osteoinductive and anti-inflammatory properties. Bioact Mater 24:361\u2013375. https:\/\/doi.org\/10.1016\/j.bioactmat.2022.12.015","journal-title":"Bioact Mater"},{"key":"5728_CR17","doi-asserted-by":"publisher","DOI":"10.1002\/bmm2.70034","volume":"4","author":"L Cui","year":"2026","unstructured":"Cui L, Huang H, Zheng Y et al (2026) Programmatic regulation of macrophage polarization by HAp@MXene nanocomposites to promote bone repair. BMEMat 4:e70034. https:\/\/doi.org\/10.1002\/bmm2.70034","journal-title":"BMEMat"},{"key":"5728_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.149311","volume":"484","author":"Y Jin","year":"2024","unstructured":"Jin Y, Shu M, Liu Z et al (2024) Bio-functional immunomodulatory europium-doped hydroxyapatite nanorods for osteochondral repair via CDH5-RAS-RAF-MEK-ERK-CSF1 axis. Chem Eng J 484:149311. https:\/\/doi.org\/10.1016\/j.cej.2024.149311","journal-title":"Chem Eng J"},{"key":"5728_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.132416","volume":"270","author":"Y Xie","year":"2024","unstructured":"Xie Y, Wang Z, Liu L et al (2024) Fucoidan-hybrid hydroxyapatite nanoparticles promote the osteogenic differentiation of human periodontal ligament stem cells under inflammatory condition. Int J Biol Macromol 270:132416. https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.132416","journal-title":"Int J Biol Macromol"},{"key":"5728_CR20","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1186\/s13018-024-05202-z","volume":"19","author":"X Liu","year":"2024","unstructured":"Liu X, Chen R, Cui G et al (2024) Exosomes derived from platelet-rich plasma present a novel potential in repairing knee articular cartilage defect combined with cyclic peptide-modified \u03b2-TCP scaffold. J Orthop Surg 19:718. https:\/\/doi.org\/10.1186\/s13018-024-05202-z","journal-title":"J Orthop Surg"},{"key":"5728_CR21","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29143263","volume":"29","author":"JI Castro","year":"2024","unstructured":"Castro JI, Payan-Valero A, Valencia-Llano C-H et al (2024) Graphene oxide nanosheets for bone tissue regeneration. Molecules 29:3263. https:\/\/doi.org\/10.3390\/molecules29143263","journal-title":"Molecules"},{"key":"5728_CR22","doi-asserted-by":"publisher","first-page":"616","DOI":"10.3390\/ph18050616","volume":"18","author":"MA Sauce-Guevara","year":"2025","unstructured":"Sauce-Guevara MA, Garc\u00eda-Schejtman SD, Alarcon EI et al (2025) Development and Characterization of an Injectable Alginate\/Chitosan Composite Hydrogel Reinforced with Cyclic-RGD Functionalized Graphene Oxide for Potential Tissue Regeneration Applications. Pharmaceuticals 18:616. https:\/\/doi.org\/10.3390\/ph18050616","journal-title":"Pharmaceuticals"},{"key":"5728_CR23","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.4014\/jmb.2402.02055","volume":"34","author":"H Huang","year":"2024","unstructured":"Huang H, Han R, Huang P-P et al (2024) Preparation and Performance Evaluation of a Zinc Oxide-Graphene Oxideloaded Chitosan-Based Thermosensitive Gel. J Microbiol Biotechnol 34:1229\u20131238. https:\/\/doi.org\/10.4014\/jmb.2402.02055","journal-title":"J Microbiol Biotechnol"},{"key":"5728_CR24","doi-asserted-by":"publisher","DOI":"10.3390\/nano11082046","volume":"11","author":"H-S Hung","year":"2021","unstructured":"Hung H-S, Kung M-L, Chen F-C et al (2021) Nanogold-carried graphene oxide: anti-inflammation and increased differentiation capacity of mesenchymal stem cells. Nanomaterials (Basel, Switzerland) 11:2046. https:\/\/doi.org\/10.3390\/nano11082046","journal-title":"Nanomaterials (Basel, Switzerland)"},{"key":"5728_CR25","doi-asserted-by":"publisher","first-page":"5653","DOI":"10.1039\/D3NR06033K","volume":"16","author":"L Ogene","year":"2024","unstructured":"Ogene L, Woods S, Hetmanski J et al (2024) Graphene oxide activates canonical TGF\u03b2 signalling in a human chondrocyte cell line via increased plasma membrane tension. Nanoscale 16:5653\u20135664. https:\/\/doi.org\/10.1039\/D3NR06033K","journal-title":"Nanoscale"},{"key":"5728_CR26","doi-asserted-by":"publisher","DOI":"10.3390\/nu17132069","volume":"17","author":"AF Amhare","year":"2025","unstructured":"Amhare AF, Liu H, Qiao L et al (2025) Elemental influence: the emerging role of zinc, copper, and selenium in osteoarthritis. Nutrients 17:2069. https:\/\/doi.org\/10.3390\/nu17132069","journal-title":"Nutrients"},{"key":"5728_CR27","volume-title":"ISO 10993-5:2009. Biological evaluation of medical devices \u2014 Part 5: Tests for in vitro cytotoxicity","author":"International Organization for Standardization","year":"2009","unstructured":"International Organization for Standardization (2009) ISO 10993-5:2009. Biological evaluation of medical devices \u2014 Part 5: Tests for in vitro cytotoxicity. ISO, Geneva, Switzerland"},{"key":"5728_CR28","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1302\/2058-5241.4.180102","volume":"4","author":"S Donell","year":"2019","unstructured":"Donell S (2019) Subchondral bone remodelling in osteoarthritis. EFORT Open Rev 4:221\u2013229. https:\/\/doi.org\/10.1302\/2058-5241.4.180102","journal-title":"EFORT Open Rev"},{"key":"5728_CR29","doi-asserted-by":"publisher","first-page":"1201019","DOI":"10.3389\/fragi.2023.1201019","volume":"4","author":"A Tonutti","year":"2023","unstructured":"Tonutti A, Granata V, Marrella V et al (2023) The role of WNT and IL-1 signaling in osteoarthritis: therapeutic implications for platelet-rich plasma therapy. Front Aging 4:1201019. https:\/\/doi.org\/10.3389\/fragi.2023.1201019","journal-title":"Front Aging"},{"key":"5728_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/biology14030250","volume":"14","author":"E Steemers","year":"2025","unstructured":"Steemers E, Talbi WMI, Hogervorst JMA et al (2025) IL-1 receptor antagonist anakinra inhibits the effect of IL-1\u03b2- mediated osteoclast formation by periodontal ligament fibroblasts. Biology (Basel) 14:250. https:\/\/doi.org\/10.3390\/biology14030250","journal-title":"Biology (Basel)"},{"key":"5728_CR31","doi-asserted-by":"publisher","first-page":"324","DOI":"10.4103\/jomfp.jomfp_304_24","volume":"29","author":"S Swetha","year":"2025","unstructured":"Swetha S, Rao GN, Mahalakshmi V, Sathya R (2025) Alkaline phosphatase and acid phosphatase in health and disease \u2013 A systematic review. J Oral Maxillofac Pathol 29:324\u2013334. https:\/\/doi.org\/10.4103\/jomfp.jomfp_304_24","journal-title":"J Oral Maxillofac Pathol"},{"issue":"1","key":"5728_CR32","doi-asserted-by":"publisher","first-page":"14472","DOI":"10.1038\/s41598-023-40835-w","volume":"13","author":"OS Yevlashevskaya","year":"2023","unstructured":"Yevlashevskaya OS, Scheven BA, Walmsley AD, Shelton RM (2023) Differing responses of osteogenic cell lines to \u03b2-glycerophosphate. Sci Rep 13:14472. https:\/\/doi.org\/10.1038\/s41598-023-40835-w","journal-title":"Sci Rep"},{"key":"5728_CR33","doi-asserted-by":"publisher","DOI":"10.3390\/nu16234012","volume":"16","author":"E Balogh","year":"2024","unstructured":"Balogh E, T\u00f3th A, Csiki DM, Jeney V (2024) Zinc ameliorates high Pi and Ca-mediated osteogenic differentiation of mesenchymal stem cells. Nutrients 16:4012. https:\/\/doi.org\/10.3390\/nu16234012","journal-title":"Nutrients"},{"key":"5728_CR34","doi-asserted-by":"publisher","DOI":"10.3390\/cells13242046","volume":"13","author":"H-J Lee","year":"2024","unstructured":"Lee H-J, Kim D-Y, Noh HJ et al (2024) Elevated IL-6 expression in autologous adipose-derived stem cells regulates RANKL mediated inflammation in osteoarthritis. Cells (Basel) 13:2046. https:\/\/doi.org\/10.3390\/cells13242046","journal-title":"Cells (Basel)"},{"key":"5728_CR35","doi-asserted-by":"publisher","first-page":"2681","DOI":"10.1093\/rheumatology\/keaa248","volume":"59","author":"R Wiegertjes","year":"2020","unstructured":"Wiegertjes R, Van De Loo FAJ, Blaney Davidson EN (2020) A roadmap to target interleukin-6 in osteoarthritis. Rheumatology 59:2681\u20132694. https:\/\/doi.org\/10.1093\/rheumatology\/keaa248","journal-title":"Rheumatology"},{"key":"5728_CR36","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2025.2501880","volume":"16","author":"SP Hiruthyaswamy","year":"2025","unstructured":"Hiruthyaswamy SP, Bose A, Upadhyay A et al (2025) Molecular signaling pathways in osteoarthritis and biomaterials for cartilage regeneration: a review. Bioengineered (Austin) 16:2501880. https:\/\/doi.org\/10.1080\/21655979.2025.2501880","journal-title":"Bioengineered (Austin)"},{"key":"5728_CR37","doi-asserted-by":"publisher","DOI":"10.3390\/ijms262411858","volume":"26","author":"S Cheng","year":"2025","unstructured":"Cheng S, Liu H, Yang X et al (2025) Transcriptomics and metabolomics insights into the dysregulation of chondrocyte differentiation induced by T-2 toxin. Int J Mol Sci 26:11858. https:\/\/doi.org\/10.3390\/ijms262411858","journal-title":"Int J Mol Sci"},{"key":"5728_CR38","doi-asserted-by":"publisher","first-page":"110805","DOI":"10.1016\/j.compositesb.2023.110805","volume":"262","author":"Q Liu","year":"2023","unstructured":"Liu Q, Peng X, Liu X et al (2023) Advances in the application of bone morphogenetic proteins and their derived peptides in bone defect repair. Compos Part B Eng 262:110805. https:\/\/doi.org\/10.1016\/j.compositesb.2023.110805","journal-title":"Compos Part B Eng"},{"key":"5728_CR39","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-025-05622-y","volume":"82","author":"T-Y Ha","year":"2025","unstructured":"Ha T-Y, Chan S-W, Wang Z et al (2025) SOX9 haploinsufficiency reveals SOX9-Noggin interaction in BMP-SMAD signaling pathway in chondrogenesis. Cell Mol Life Sci 82:99. https:\/\/doi.org\/10.1007\/s00018-025-05622-y","journal-title":"Cell Mol Life Sci"},{"key":"5728_CR40","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1042\/CS20150622","volume":"130","author":"S-Y Chien","year":"2016","unstructured":"Chien S-Y, Huang C-Y, Tsai C-H et al (2016) Interleukin-1\u03b2 induces fibroblast growth factor 2 expression and subsequently promotes endothelial progenitor cell angiogenesis in chondrocytes. Clin Sci 130:667\u2013681. https:\/\/doi.org\/10.1042\/CS20150622","journal-title":"Clin Sci"},{"key":"5728_CR41","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1698404","volume":"16","author":"C Zhou","year":"2026","unstructured":"Zhou C, Hu X, Jing Y et al (2026) Bidirectional crosstalk between the bone extracellular matrix and lysosomes in bone remodeling and osteoporosis. Front Endocrinol 16:1698404. https:\/\/doi.org\/10.3389\/fendo.2025.1698404","journal-title":"Front Endocrinol"},{"key":"5728_CR42","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2025.1661846","volume":"13","author":"S St\u00fccker","year":"2025","unstructured":"St\u00fccker S, Rellmann Y, Schulte S, Dreier R (2025) ER-resident proteins are key players in cartilage and bone homeostasis. Front Cell Dev Biol 13:1661846. https:\/\/doi.org\/10.3389\/fcell.2025.1661846","journal-title":"Front Cell Dev Biol"},{"key":"5728_CR43","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1007\/s10753-023-01840-3","volume":"46","author":"P Zhang","year":"2023","unstructured":"Zhang P, Xiao J, Luo C et al (2023) The Effect of JAK Inhibitor Tofacitinib on Chondrocyte Autophagy. Inflammation 46:1764\u20131776. https:\/\/doi.org\/10.1007\/s10753-023-01840-3","journal-title":"Inflammation"},{"key":"5728_CR44","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1495613","volume":"16","author":"KWY Smith","year":"2025","unstructured":"Smith KWY, Fung SL, Wu H-F et al (2025) Developing an in vitro osteochondral micro-physiological system for modeling cartilage-bone crosstalk in arthritis. Front Immunol 16:1495613. https:\/\/doi.org\/10.3389\/fimmu.2025.1495613","journal-title":"Front Immunol"},{"key":"5728_CR45","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.jor.2023.02.014","volume":"38","author":"S Singh","year":"2023","unstructured":"Singh S, Jindal D, Khanna R (2023) Can serum MMP-3 diagnose early knee osteoarthritis? J Orthop 38:42\u201346. https:\/\/doi.org\/10.1016\/j.jor.2023.02.014","journal-title":"J Orthop"},{"key":"5728_CR46","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202500467","volume":"26","author":"C Roy","year":"2026","unstructured":"Roy C, Sharma A, Chakraborty J et al (2026) Exploring the role of cartilage hypertrophy in osteoarthritis progression: a structural and biochemical analysis of glycosaminoglycan loss and ECM integrity. Macromol Biosci 26:e00467. https:\/\/doi.org\/10.1002\/mabi.202500467","journal-title":"Macromol Biosci"},{"key":"5728_CR47","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.62347\/JWGW7377","volume":"14","author":"T Han","year":"2024","unstructured":"Han T (2024) Collagen type X expression and chondrocyte hypertrophic differentiation during OA and OS development. Am J Cancer Res 14:1784\u20131801. https:\/\/doi.org\/10.62347\/JWGW7377","journal-title":"Am J Cancer Res"},{"key":"5728_CR48","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1080\/10409230290771546","volume":"37","author":"PE Van Den Steen","year":"2002","unstructured":"Van Den Steen PE, Dubois B, Nelissen I et al (2002) Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9). Crit Rev Biochem Mol Biol 37:375\u2013536. https:\/\/doi.org\/10.1080\/10409230290771546","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"5728_CR49","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-58122-9","volume":"16","author":"J Xiong","year":"2025","unstructured":"Xiong J, Ma R, Xie K et al (2025) Recapitulation of endochondral ossification by hPSC-derived SOX9+ sclerotomal progenitors. Nat Commun 16:2781. https:\/\/doi.org\/10.1038\/s41467-025-58122-9","journal-title":"Nat Commun"},{"key":"5728_CR50","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1161\/CIRCRESAHA.123.323365","volume":"134","author":"M Faleeva","year":"2024","unstructured":"Faleeva M, Ahmad S, Theofilatos K et al (2024) Sox9 Accelerates Vascular Aging by Regulating Extracellular Matrix Composition and Stiffness. Circ Res 134:307\u2013324. https:\/\/doi.org\/10.1161\/CIRCRESAHA.123.323365","journal-title":"Circ Res"},{"key":"5728_CR51","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1016\/j.ymthe.2024.06.016","volume":"32","author":"L Zhao","year":"2024","unstructured":"Zhao L, Lai Y, Jiao H et al (2024) CRISPR-mediated Sox9 activation and RelA inhibition enhance cell therapy for osteoarthritis. Mol Ther 32:2549\u20132562. https:\/\/doi.org\/10.1016\/j.ymthe.2024.06.016","journal-title":"Mol Ther"},{"key":"5728_CR52","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/978-981-10-3233-2_6","volume-title":"RUNX Proteins in Development and Cancer","author":"T Komori","year":"2017","unstructured":"Komori T (2017) Roles of Runx2 in Skeletal Development. In: Groner Y, Ito Y, Liu P (eds) RUNX Proteins in Development and Cancer. Springer Singapore, Singapore, pp 83\u201393"},{"key":"5728_CR53","doi-asserted-by":"publisher","DOI":"10.3390\/biom14111392","volume":"14","author":"K Azarkina","year":"2024","unstructured":"Azarkina K, Gromova E, Malashicheva A (2024) A friend among strangers\u201d or the ambiguous roles of Runx2. Biomolecules 14:1392. https:\/\/doi.org\/10.3390\/biom14111392","journal-title":"Biomolecules"},{"key":"5728_CR54","first-page":"3743","volume":"24","author":"C Pautke","year":"2004","unstructured":"Pautke C, Schieker M, Tischer T et al (2004) Characterization of osteosarcoma cell lines MG-63, Saos-2 and U-2 OS in comparison to human osteoblasts. Anticancer Res 24:3743\u20133748","journal-title":"Anticancer Res"},{"key":"5728_CR55","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.joca.2005.04.004","volume":"13","author":"M Gebauer","year":"2005","unstructured":"Gebauer M, Saas J, Sohler F et al (2005) Comparison of the chondrosarcoma cell line SW1353 with primary human adult articular chondrocytes with regard to their gene expression profile and reactivity to IL-1\u03b2. Osteoarthritis Cartilage 13:697\u2013708. https:\/\/doi.org\/10.1016\/j.joca.2005.04.004","journal-title":"Osteoarthritis Cartilage"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-026-05728-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-026-05728-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-026-05728-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T07:55:47Z","timestamp":1792569347000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-026-05728-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,8]]},"references-count":55,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["5728"],"URL":"https:\/\/doi.org\/10.1007\/s11010-026-05728-2","relation":{},"ISSN":["1573-4919"],"issn-type":[{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,8]]},"assertion":[{"value":"23 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}