{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T08:39:49Z","timestamp":1792571989346,"version":"4.5.0"},"reference-count":101,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2019-04885"],"award-info":[{"award-number":["RGPIN-2019-04885"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2021-02969"],"award-info":[{"award-number":["RGPIN-2021-02969"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","award":["37105"],"award-info":[{"award-number":["37105"]}],"id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"DOI":"10.1007\/s11010-026-05750-4","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:43:36Z","timestamp":1790232216000},"page":"5621-5645","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phytoestrogens and related microbial metabolites remodel aberrant prostate transcriptomic profiles generated upon exposure to oxidative stress"],"prefix":"10.1007","volume":"481","author":[{"given":"Jiaxi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arian","family":"Abolhassani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cayla","family":"Boycott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Tello-Palencia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Papierska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maidinai","family":"Sabier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David D.","family":"Kitts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Stefanska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"5750_CR1","doi-asserted-by":"publisher","first-page":"485","DOI":"10.3322\/caac.70028","volume":"75","author":"TB Kratzer","year":"2025","unstructured":"Kratzer TB, Mazzitelli N, Star J, Dahut WL, Jemal A, Siegel RL (2025) Prostate cancer statistics, 2025. CA Cancer J Clin 75:485\u2013497. https:\/\/doi.org\/10.3322\/caac.70028","journal-title":"CA Cancer J Clin"},{"key":"5750_CR2","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1007\/s12672-025-02245-4","volume":"16","author":"Y Song","year":"2025","unstructured":"Song Y, Hou Z, Zhu L, Chen Y, Li J (2025) Oxidative stress as a catalyst in prostate cancer progression: unraveling molecular mechanisms and exploring therapeutic interventions. Discov Oncol 16:457. https:\/\/doi.org\/10.1007\/s12672-025-02245-4","journal-title":"Discov Oncol"},{"key":"5750_CR3","doi-asserted-by":"publisher","first-page":"119","DOI":"10.4149\/neo_2015_015","volume":"62","author":"K Szewczyk-Golec","year":"2015","unstructured":"Szewczyk-Golec K, Tyloch J, Czuczejko J (2015) Antioxidant defense system in prostate adenocarcinoma and benign prostate hyperplasia of elderly patients. Neoplasma 62:119\u2013123. https:\/\/doi.org\/10.4149\/neo_2015_015","journal-title":"Neoplasma"},{"key":"5750_CR4","doi-asserted-by":"publisher","first-page":"1428911","DOI":"10.3389\/fnut.2024.1428911","volume":"11","author":"Y Huang","year":"2024","unstructured":"Huang Y, Wang W, Jin J (2024) Association between polyphenol subclasses and prostate cancer: a systematic review and meta-analysis of observational studies. Front Nutr 11:1428911. https:\/\/doi.org\/10.3389\/fnut.2024.1428911","journal-title":"Front Nutr"},{"key":"5750_CR5","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.820969","volume":"13","author":"YX Goh","year":"2022","unstructured":"Goh YX, Jalil J, Lam KW, Husain K, Premakumar CM (2022) Genistein: a review on its anti-inflammatory properties. Front Pharmacol 13:820969. https:\/\/doi.org\/10.3389\/fphar.2022.820969","journal-title":"Front Pharmacol"},{"key":"5750_CR6","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1323377","volume":"14","author":"P Liu","year":"2023","unstructured":"Liu P, Tang W, Xiang K, Li G (2023) Pterostilbene in the treatment of inflammatory and oncological diseases. Front Pharmacol 14:1323377. https:\/\/doi.org\/10.3389\/fphar.2023.1323377","journal-title":"Front Pharmacol"},{"key":"5750_CR7","doi-asserted-by":"publisher","DOI":"10.3390\/nu15234856","volume":"15","author":"H Van der Eecken","year":"2023","unstructured":"Van der Eecken H, Joniau S, Berghen C, Rans K, De Meerleer G (2023) The use of soy isoflavones in the treatment of prostate cancer: a focus on the cellular effects. Nutrients 15:4856. https:\/\/doi.org\/10.3390\/nu15234856","journal-title":"Nutrients"},{"key":"5750_CR8","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14080904","volume":"14","author":"K Zhang","year":"2025","unstructured":"Zhang K, Wang J, Xu B (2025) Critical review on molecular mechanisms for genistein\u2019s beneficial effects on health through oxidative stress reduction. Antioxidants 14:904. https:\/\/doi.org\/10.3390\/antiox14080904","journal-title":"Antioxidants"},{"key":"5750_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27196316","volume":"27","author":"S Nagarajan","year":"2022","unstructured":"Nagarajan S, Mohandas S, Ganesan K, Xu B, Ramkumar KM (2022) New insights into dietary pterostilbene: sources, metabolism, and health promotion effects. Molecules 27:6316. https:\/\/doi.org\/10.3390\/molecules27196316","journal-title":"Molecules"},{"key":"5750_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114606","volume":"162","author":"AB Jena","year":"2023","unstructured":"Jena AB, Samal RR, Bhol NK, Duttaroy AK (2023) Cellular red-ox system in health and disease: the latest update. Biomed Pharmacother 162:114606. https:\/\/doi.org\/10.1016\/j.biopha.2023.114606","journal-title":"Biomed Pharmacother"},{"key":"5750_CR11","doi-asserted-by":"publisher","first-page":"3379","DOI":"10.7150\/ijbs.106219","volume":"21","author":"Z Xi","year":"2025","unstructured":"Xi Z, Liu M, Jiang X, Feng J, Dai R, Nik Nabil WN, Sun X, Chen J, Ren H, Zhang J, Dong Q, Yuan M, Li Y, Xu H (2025) Pterostilbene induces apoptosis in awakening quiescent prostate cancer cells by upregulating C\/EBP-beta-mediated SOD2 transcription. Int J Biol Sci 21:3379\u20133396. https:\/\/doi.org\/10.7150\/ijbs.106219","journal-title":"Int J Biol Sci"},{"key":"5750_CR12","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1158\/1940-6207.CAPR-21-0242","volume":"15","author":"R Hemani","year":"2022","unstructured":"Hemani R, Patel I, Inamdar N, Campanelli G, Donovan V, Kumar A, Levenson AS (2022) Dietary pterostilbene for MTA1-targeted interception in high-risk premalignant prostate cancer. Cancer Prev Res (Phila) 15:87\u2013100. https:\/\/doi.org\/10.1158\/1940-6207.CAPR-21-0242","journal-title":"Cancer Prev Res (Phila)"},{"key":"5750_CR13","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1039\/d5fo04237b","volume":"17","author":"HY Tsai","year":"2026","unstructured":"Tsai HY, Liu ZL, Kuan CY, Ho CT, Chen YK (2026) 3\u2019-Hydroxypterostilbene suppresses prostate cancer via apoptosis and autophagy in vitro and potent tumor growth inhibition in vivo. Food Funct 17:1018\u20131031. https:\/\/doi.org\/10.1039\/d5fo04237b","journal-title":"Food Funct"},{"key":"5750_CR14","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-9-4","volume":"9","author":"TD Lund","year":"2011","unstructured":"Lund TD, Blake C, Bu L, Hamaker AN, Lephart ED (2011) Equol an isoflavonoid: potential for improved prostate health, in vitro and in vivo evidence. Reprod Biol Endocrinol 9:4. https:\/\/doi.org\/10.1186\/1477-7827-9-4","journal-title":"Reprod Biol Endocrinol"},{"key":"5750_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24061155","volume":"24","author":"V Jarosova","year":"2019","unstructured":"Jarosova V, Vesely O, Marsik P, Jaimes JD, Smejkal K, Kloucek P, Havlik J (2019) Metabolism of stilbenoids by human faecal microbiota. Molecules 24:1155. https:\/\/doi.org\/10.3390\/molecules24061155","journal-title":"Molecules"},{"key":"5750_CR16","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1002\/mnfr.201500989","volume":"60","author":"Y Sun","year":"2016","unstructured":"Sun Y, Wu X, Cai X, Song M, Zheng J, Pan C, Qiu P, Zhang L, Zhou S, Tang Z, Xiao H (2016) Identification of pinostilbene as a major colonic metabolite of pterostilbene and its inhibitory effects on colon cancer cells. Mol Nutr Food Res 60:1924\u20131932. https:\/\/doi.org\/10.1002\/mnfr.201500989","journal-title":"Mol Nutr Food Res"},{"key":"5750_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-43561-5","volume":"13","author":"WS Shin","year":"2023","unstructured":"Shin WS, Han SH, Jo KW, Cho Y, Kim KT (2023) Pinostilbene inhibits full-length and splice variant of androgen receptor in prostate cancer. Sci Rep 13:16663. https:\/\/doi.org\/10.1038\/s41598-023-43561-5","journal-title":"Sci Rep"},{"key":"5750_CR18","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/594656","volume":"2015","author":"ED Lephart","year":"2015","unstructured":"Lephart ED (2015) Modulation of aromatase by phytoestrogens. Enzyme Res 2015:594656. https:\/\/doi.org\/10.1155\/2015\/594656","journal-title":"Enzyme Res"},{"key":"5750_CR19","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2025.2473770","volume":"20","author":"Y Ma","year":"2025","unstructured":"Ma Y, Boycott C, Zhang J, Gomilar R, Yang T, Stefanska B (2025) SIRT1\/DNMT3B-mediated epigenetic gene silencing in response to phytoestrogens in mammary epithelial cells. Epigenetics 20:2473770. https:\/\/doi.org\/10.1080\/15592294.2025.2473770","journal-title":"Epigenetics"},{"key":"5750_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2021.108815","volume":"98","author":"M Beetch","year":"2021","unstructured":"Beetch M, Boycott C, Harandi-Zadeh S, Yang T, Martin BJE, Dixon-McDougall T, Ren K, Gacad A, Dupuis JH, Ullmer M, Lubecka K, Yada RY, Brown CJ, Howe LJ, Stefanska B (2021) Pterostilbene leads to DNMT3B-mediated DNA methylation and silencing of OCT1-targeted oncogenes in breast cancer cells. J Nutr Biochem 98:108815. https:\/\/doi.org\/10.1016\/j.jnutbio.2021.108815","journal-title":"J Nutr Biochem"},{"key":"5750_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102948","volume":"68","author":"K Mu","year":"2023","unstructured":"Mu K, Kitts DD (2023) Intestinal polyphenol antioxidant activity involves redox signaling mechanisms facilitated by aquaporin activity. Redox Biol 68:102948. https:\/\/doi.org\/10.1016\/j.redox.2023.102948","journal-title":"Redox Biol"},{"key":"5750_CR22","doi-asserted-by":"publisher","first-page":"3022","DOI":"10.1021\/acs.jafc.2c08830","volume":"71","author":"K Mu","year":"2023","unstructured":"Mu K, Kitts DD (2023) Hydrogen peroxide produced from selective phenolic acids in cell culture underlies Caco-2 changes in cell proliferation parameters. J Agric Food Chem 71:3022\u20133032. https:\/\/doi.org\/10.1021\/acs.jafc.2c08830","journal-title":"J Agric Food Chem"},{"key":"5750_CR23","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1080\/15592294.2022.2069386","volume":"17","author":"C Boycott","year":"2022","unstructured":"Boycott C, Beetch M, Yang T, Lubecka K, Ma Y, Zhang J, Kurzava Kendall L, Ullmer M, Ramsey BS, Torregrosa-Allen S, Elzey BD, Cox A, Lanman NA, Hui A, Villanueva N, de Conti A, Huan T, Pogribny I, Stefanska B (2022) Epigenetic aberrations of gene expression in a rat model of hepatocellular carcinoma. Epigenetics 17:1513\u20131534. https:\/\/doi.org\/10.1080\/15592294.2022.2069386","journal-title":"Epigenetics"},{"key":"5750_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ab.2014.08.027","volume":"467","author":"B Rivero-Guti\u00e9rrez","year":"2014","unstructured":"Rivero-Guti\u00e9rrez B, Anzola A, Mart\u00ednez-Augustin O, de Medina FS (2014) Stain-free detection as loading control alternative to Ponceau and housekeeping protein immunodetection in Western blotting. Anal Biochem 467:1\u20133. https:\/\/doi.org\/10.1016\/j.ab.2014.08.027","journal-title":"Anal Biochem"},{"key":"5750_CR25","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/nmeth.4197","volume":"14","author":"R Patro","year":"2017","unstructured":"Patro R, Duggal G, Love MI, Irizarry RA, Kingsford C (2017) Salmon provides fast and bias-aware quantification of transcript expression. Nat Methods 14:417\u2013419. https:\/\/doi.org\/10.1038\/nmeth.4197","journal-title":"Nat Methods"},{"key":"5750_CR26","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.70217","author":"C Boycott","year":"2025","unstructured":"Boycott C, Beetch M, Lubecka-Gajewska K, Ramsey BS, Torregrosa-Allen S, Elzey BD, Cox A, Lanman NA, de Conti A, Li M, Ferruzzi M, Pogribny I, Stefanska B (2025) AMPK-dependent epigenetic regulation of metabolism mediates the anti-cancer action of pterostilbene in hepatocellular carcinoma. Mol Nutr Food Res. https:\/\/doi.org\/10.1002\/mnfr.70217","journal-title":"Mol Nutr Food Res"},{"key":"5750_CR27","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S (2014) Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol 15:550. https:\/\/doi.org\/10.1186\/s13059-014-0550-8","journal-title":"Genome Biol"},{"key":"5750_CR28","doi-asserted-by":"publisher","first-page":"2628","DOI":"10.1093\/bioinformatics\/btz931","volume":"36","author":"SX Ge","year":"2020","unstructured":"Ge SX, Jung D, Yao R (2020) ShinyGO: a graphical gene-set enrichment tool for animals and plants. Bioinformatics 36:2628\u20132629. https:\/\/doi.org\/10.1093\/bioinformatics\/btz931","journal-title":"Bioinformatics"},{"key":"5750_CR29","doi-asserted-by":"publisher","DOI":"10.3390\/cells7100156","volume":"7","author":"N Di Marzo","year":"2018","unstructured":"Di Marzo N, Chisci E, Giovannoni R (2018) The role of hydrogen peroxide in redox-dependent signaling: homeostatic and pathological responses in mammalian cells. Cells 7:156. https:\/\/doi.org\/10.3390\/cells7100156","journal-title":"Cells"},{"key":"5750_CR30","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4358292","author":"F Martignano","year":"2016","unstructured":"Martignano F, Gurioli G, Salvi S, Calistri D, Costantini M, Gunelli R, De Giorgi U, Foca F, Casadio V (2016) GSTP1 methylation and protein expression in prostate cancer: diagnostic implications. Dis Markers. https:\/\/doi.org\/10.1155\/2016\/4358292","journal-title":"Dis Markers"},{"key":"5750_CR31","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/s41392-024-01757-9","volume":"9","author":"Q Guo","year":"2024","unstructured":"Guo Q, Jin Y, Chen X, Ye X, Shen X, Lin M, Zeng C, Zhou T, Zhang J (2024) NF-kappaB in biology and targeted therapy: new insights and translational implications. Signal Transduct Target Ther 9:53. https:\/\/doi.org\/10.1038\/s41392-024-01757-9","journal-title":"Signal Transduct Target Ther"},{"key":"5750_CR32","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.freeradbiomed.2019.01.028","volume":"134","author":"KJA Davies","year":"2019","unstructured":"Davies KJA, Forman HJ (2019) Does Bach1 & c-Myc dependent redox dysregulation of Nrf2 & adaptive homeostasis decrease cancer risk in ageing? Free Radic Biol Med 134:708\u2013714. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2019.01.028","journal-title":"Free Radic Biol Med"},{"key":"5750_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101553","volume":"34","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Park J, Han SJ, Yang SY, Yoon HJ, Park I, Woo HA, Lee SR (2020) Redox regulation of tumor suppressor PTEN in cell signaling. Redox Biol 34:101553. https:\/\/doi.org\/10.1016\/j.redox.2020.101553","journal-title":"Redox Biol"},{"key":"5750_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217214","volume":"602","author":"Q He","year":"2024","unstructured":"He Q, Zhang Y, Li W, Chen S, Xiong J, Zhao R, Yuan K, Hu Q, Liu S, Gao G, Bedford MT, Tang DG, Xu B, Zou C, Zhang D (2024) Inhibition of PRMT5 moderately suppresses prostate cancer growth in vivo but enhances its response to immunotherapy. Cancer Lett 602:217214. https:\/\/doi.org\/10.1016\/j.canlet.2024.217214","journal-title":"Cancer Lett"},{"key":"5750_CR35","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrurol.2017.167","volume":"15","author":"KS Sfanos","year":"2018","unstructured":"Sfanos KS, Yegnasubramanian S, Nelson WG, De Marzo AM (2018) The inflammatory microenvironment and microbiome in prostate cancer development. Nat Rev Urol 15:11\u201324. https:\/\/doi.org\/10.1038\/nrurol.2017.167","journal-title":"Nat Rev Urol"},{"key":"5750_CR36","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1038\/s41416-021-01435-5","volume":"125","author":"F Ahmad","year":"2021","unstructured":"Ahmad F, Cherukuri MK, Choyke PL (2021) Metabolic reprogramming in prostate cancer. Br J Cancer 125:1185\u20131196. https:\/\/doi.org\/10.1038\/s41416-021-01435-5","journal-title":"Br J Cancer"},{"key":"5750_CR37","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13020183","volume":"13","author":"UR Wanjari","year":"2023","unstructured":"Wanjari UR, Mukherjee AG, Gopalakrishnan AV, Murali R, Dey A, Vellingiri B, Ganesan R (2023) Role of metabolism and metabolic pathways in prostate cancer. Metabolites 13:183","journal-title":"Metabolites"},{"key":"5750_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10715762.2019.1702656","volume":"54","author":"GBN Chainy","year":"2020","unstructured":"Chainy GBN, Sahoo DK (2020) Hormones and oxidative stress: an overview. Free Radic Res 54:1\u201326. https:\/\/doi.org\/10.1080\/10715762.2019.1702656","journal-title":"Free Radic Res"},{"key":"5750_CR39","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/978-981-15-0602-4_9","volume-title":"Autophagy: biology and diseases: basic science","author":"Q Gao","year":"2019","unstructured":"Gao Q (2019) Oxidative stress and autophagy. In: Qin Z-H (ed) Autophagy: biology and diseases: basic science. Springer Singapore, Singapore, pp 179\u2013198"},{"key":"5750_CR40","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1002\/pros.23100","volume":"76","author":"P Vital","year":"2016","unstructured":"Vital P, Castro P, Ittmann M (2016) Oxidative stress promotes benign prostatic hyperplasia. Prostate 76:58\u201367. https:\/\/doi.org\/10.1002\/pros.23100","journal-title":"Prostate"},{"key":"5750_CR41","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1038\/nrurol.2017.144","volume":"14","author":"V Murillo-Garz\u00f3n","year":"2017","unstructured":"Murillo-Garz\u00f3n V, Kypta R (2017) WNT signalling in prostate cancer. Nat Rev Urol 14:683\u2013696. https:\/\/doi.org\/10.1038\/nrurol.2017.144","journal-title":"Nat Rev Urol"},{"key":"5750_CR42","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-025-01042-y","author":"Z Liu","year":"2025","unstructured":"Liu Z, Peng Q, Wang Y, Chiu PK, Teoh JY, Wang R, Liu X, Wu D, Ng CF (2025) Neuroscience in prostate cancer. Prostate Cancer Prostatic Dis. https:\/\/doi.org\/10.1038\/s41391-025-01042-y","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"5750_CR43","doi-asserted-by":"publisher","first-page":"eadx0027","DOI":"10.1126\/scitranslmed.adx0027","volume":"17","author":"R D\u2019Oliveira Albanus","year":"2025","unstructured":"D\u2019Oliveira Albanus R, Finan GM, Brase L, Sweeney N, Kim TY, Chen S, Ryoo Y, Park J, Guo Q, Iyer AK, Acquarone M, You SF, Novotny BC, Mace EM, Ribeiro Pereira PM, Morris JC, Holtzman DM, McDade E, Farlow M, Chhatwal JP, Benitez BA, Piccio L, Perrin RJ, Sutherland GT, Ma Q, Karch CM, Kim DY, Tanzi RE, Fu H, Harari O, Kim TW (2025) Systematic analysis of cellular cross-talk reveals a role for SEMA6D-TREM2 regulating microglial function in Alzheimer\u2019s disease. Sci Transl Med 17:eadx0027. https:\/\/doi.org\/10.1126\/scitranslmed.adx0027","journal-title":"Sci Transl Med"},{"key":"5750_CR44","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s13046-015-0278-7","volume":"35","author":"L Belkacemi","year":"2016","unstructured":"Belkacemi L, Zhang SX (2016) Anti-tumor effects of pigment epithelium-derived factor (PEDF): implication for cancer therapy. A mini-review. J Exp Clin Cancer Res 35:4. https:\/\/doi.org\/10.1186\/s13046-015-0278-7","journal-title":"J Exp Clin Cancer Res"},{"key":"5750_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.115637","volume":"44","author":"CN Como","year":"2025","unstructured":"Como CN, O\u2019Rourke R, Winkler C, Mitchell D, Tran L, Lorberbaum D, Sussel L, Franco S, Siegenthaler J (2025) Meningeal-derived retinoic acid regulates neurogenesis via suppression of Notch and Sox2. Cell Rep 44:115637. https:\/\/doi.org\/10.1016\/j.celrep.2025.115637","journal-title":"Cell Rep"},{"key":"5750_CR46","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.stemcr.2014.01.001","volume":"2","author":"JK Rane","year":"2014","unstructured":"Rane JK, Droop AP, Pellacani D, Polson ES, Simms MS, Collins AT, Caves LS, Maitland NJ (2014) Conserved two-step regulatory mechanism of human epithelial differentiation. Stem Cell Reports 2:180\u2013188. https:\/\/doi.org\/10.1016\/j.stemcr.2014.01.001","journal-title":"Stem Cell Reports"},{"key":"5750_CR47","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20071626","volume":"20","author":"M Jimenez-Martinez","year":"2019","unstructured":"Jimenez-Martinez M, Stamatakis K, Fresno M (2019) The dual-specificity phosphatase 10 (DUSP10): its role in cancer, inflammation, and immunity. Int J Mol Sci 20:1626. https:\/\/doi.org\/10.3390\/ijms20071626","journal-title":"Int J Mol Sci"},{"key":"5750_CR48","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2024.1402996","volume":"18","author":"Y Wu","year":"2024","unstructured":"Wu Y, Wang Y, Lu Y, Yan J, Zhao H, Yang R, Pan J (2024) Research advances in huntingtin-associated protein 1 and its application prospects in diseases. Front Neurosci 18:1402996. https:\/\/doi.org\/10.3389\/fnins.2024.1402996","journal-title":"Front Neurosci"},{"key":"5750_CR49","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-023-05579-0","volume":"150","author":"J Stein","year":"2024","unstructured":"Stein J, Krappe E, Kremer A, Cronauer MV, Essler M, Cox A, Klumper N, Krausewitz P, Ellinger J, Ritter M, Kristiansen G, Majores M (2024) Expression of the microtubule-associated protein 2 (MAP2) as a potential independent prognostic marker in prostate cancer. J Cancer Res Clin Oncol 150:76. https:\/\/doi.org\/10.1007\/s00432-023-05579-0","journal-title":"J Cancer Res Clin Oncol"},{"key":"5750_CR50","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.bbi.2017.05.006","volume":"65","author":"A Borsini","year":"2017","unstructured":"Borsini A, Alboni S, Horowitz MA, Tojo LM, Cannazza G, Su KP, Pariante CM, Zunszain PA (2017) Rescue of IL-1beta-induced reduction of human neurogenesis by omega-3 fatty acids and antidepressants. Brain Behav Immun 65:230\u2013238. https:\/\/doi.org\/10.1016\/j.bbi.2017.05.006","journal-title":"Brain Behav Immun"},{"key":"5750_CR51","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01617-3","volume":"7","author":"C Everaert","year":"2017","unstructured":"Everaert C, Luypaert M, Maag JLV, Cheng QX, Dinger ME, Hellemans J, Mestdagh P (2017) Benchmarking of RNA-sequencing analysis workflows using whole-transcriptome RT-qPCR expression data. Sci Rep 7:1559. https:\/\/doi.org\/10.1038\/s41598-017-01617-3","journal-title":"Sci Rep"},{"key":"5750_CR52","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10894","volume":"7","author":"S Nobrega-Pereira","year":"2016","unstructured":"Nobrega-Pereira S, Fernandez-Marcos PJ, Brioche T, Gomez-Cabrera MC, Salvador-Pascual A, Flores JM, Vina J, Serrano M (2016) G6PD protects from oxidative damage and improves healthspan in mice. Nat Commun 7:10894. https:\/\/doi.org\/10.1038\/ncomms10894","journal-title":"Nat Commun"},{"key":"5750_CR53","doi-asserted-by":"publisher","first-page":"15771","DOI":"10.1074\/jbc.M112.448886","volume":"288","author":"T Ward","year":"2013","unstructured":"Ward T, Wang M, Liu X, Wang Z, Xia P, Chu Y, Wang X, Liu L, Jiang K, Yu H, Yan M, Wang J, Hill DL, Huang Y, Zhu T, Yao X (2013) Regulation of a dynamic interaction between two microtubule-binding proteins, EB1 and TIP150, by the mitotic p300\/CBP-associated factor (PCAF) orchestrates kinetochore microtubule plasticity and chromosome stability during mitosis. J Biol Chem 288:15771\u201315785. https:\/\/doi.org\/10.1074\/jbc.M112.448886","journal-title":"J Biol Chem"},{"key":"5750_CR54","doi-asserted-by":"publisher","DOI":"10.3390\/biom14010013","volume":"14","author":"Z Xiong","year":"2024","unstructured":"Xiong Z, Chen P, Yuan M, Yao L, Wang Z, Liu P, Jiang Y (2024) Integrated bioinformatics and validation reveal IFI27 and its related molecules as potential identifying genes in liver cirrhosis. Biomolecules 14:13","journal-title":"Biomolecules"},{"key":"5750_CR55","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1089\/jir.2014.0168","volume":"35","author":"M Bawadekar","year":"2015","unstructured":"Bawadekar M, De Andrea M, Lo Cigno I, Baldanzi G, Caneparo V, Graziani A, Landolfo S, Gariglio M (2015) The extracellular IFI16 protein propagates inflammation in endothelial cells via p38 MAPK and NF-\u03baB p65 activation. J Interferon Cytokine Res 35:441\u2013453. https:\/\/doi.org\/10.1089\/jir.2014.0168","journal-title":"J Interferon Cytokine Res"},{"key":"5750_CR56","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1038\/ejhg.2012.281","volume":"21","author":"Y Chen","year":"2013","unstructured":"Chen Y, Li J, Yu X, Li S, Zhang X, Mo Z, Hu Y (2013) APC gene hypermethylation and prostate cancer: a systematic review and meta-analysis. Eur J Hum Genet 21:929\u2013935. https:\/\/doi.org\/10.1038\/ejhg.2012.281","journal-title":"Eur J Hum Genet"},{"key":"5750_CR57","doi-asserted-by":"publisher","first-page":"eads1556","DOI":"10.1126\/sciimmunol.ads1556","volume":"10","author":"P Ramalingam","year":"2025","unstructured":"Ramalingam P, Gutkin MC, Poulos MG, Winiarski A, Smith A, Carter C, Doughty C, Tillery T, Redmond D, Freire AG, Butler JM (2025) Suppression of thrombospondin-1-mediated inflammaging prolongs hematopoietic health span. Sci Immunol 10:eads1556. https:\/\/doi.org\/10.1126\/sciimmunol.ads1556","journal-title":"Sci Immunol"},{"key":"5750_CR58","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.593245","volume":"10","author":"US Rajapaksa","year":"2020","unstructured":"Rajapaksa US, Jin C, Dong T (2020) Malignancy and IFITM3: friend or foe? Front Oncol 10:593245. https:\/\/doi.org\/10.3389\/fonc.2020.593245","journal-title":"Front Oncol"},{"key":"5750_CR59","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.biocel.2017.05.017","volume":"89","author":"G-P Voulgaridou","year":"2017","unstructured":"Voulgaridou G-P, Tsochantaridis I, Mantso T, Franco R, Panayiotidis MI, Pappa A (2017) Human aldehyde dehydrogenase 3A1 (ALDH3A1) exhibits chaperone-like function. Int J Biochem Cell Biol 89:16\u201324. https:\/\/doi.org\/10.1016\/j.biocel.2017.05.017","journal-title":"Int J Biochem Cell Biol"},{"key":"5750_CR60","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.trecan.2023.09.001","volume":"10","author":"S Nagelli","year":"2024","unstructured":"Nagelli S, Westermarck J (2024) CIP2A coordinates phosphosignaling, mitosis, and the DNA damage response. Trends Cancer 10:52\u201364. https:\/\/doi.org\/10.1016\/j.trecan.2023.09.001","journal-title":"Trends Cancer"},{"key":"5750_CR61","doi-asserted-by":"publisher","first-page":"7856","DOI":"10.1074\/jbc.M512655200","volume":"281","author":"W Yan","year":"2006","unstructured":"Yan W, Chen X (2006) GPX2, a direct target of p63, inhibits oxidative stress-induced apoptosis in a p53-dependent manner *. J Biol Chem 281:7856\u20137862. https:\/\/doi.org\/10.1074\/jbc.M512655200","journal-title":"J Biol Chem"},{"key":"5750_CR62","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7067623","author":"Q Huang","year":"2022","unstructured":"Huang Q, Peng M, Gu Y, Wu J, Zhan Y, Deng Z, Chen S, Yang R, Chen J, Xie J (2022) Metabolism-related gene TXNRD1 regulates inflammation and oxidative stress induced by cigarette smoke through the Nrf2\/HO-1 pathway in the small airway epithelium. Oxid Med Cell Longev. https:\/\/doi.org\/10.1155\/2022\/7067623","journal-title":"Oxid Med Cell Longev"},{"key":"5750_CR63","doi-asserted-by":"publisher","first-page":"2543","DOI":"10.1210\/en.2019-00283","volume":"160","author":"T Kim","year":"2019","unstructured":"Kim T, Li D, Terasaka T, Nicholas DA, Knight VS, Yang JJ, Lawson MA (2019) SRXN1 is necessary for resolution of GnRH-induced oxidative stress and induction of gonadotropin gene expression. Endocrinology 160:2543\u20132555. https:\/\/doi.org\/10.1210\/en.2019-00283","journal-title":"Endocrinology"},{"key":"5750_CR64","doi-asserted-by":"publisher","DOI":"10.3390\/nu13072210","volume":"13","author":"MPA Baldassarre","year":"2021","unstructured":"Baldassarre MPA, Di Tomo P, Centorame G, Pandolfi A, Di Pietro N, Consoli A, Formoso G (2021) Myoinositol reduces inflammation and oxidative stress in human endothelial cells exposed in vivo to chronic hyperglycemia. Nutrients 13:2210. https:\/\/doi.org\/10.3390\/nu13072210","journal-title":"Nutrients"},{"key":"5750_CR65","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2023.216527","volume":"582","author":"X Lei","year":"2024","unstructured":"Lei X, Liao R, Chen X, Wang Z, Cao Q, Bai L, Ma C, Deng X, Ma Y, Wu X, Li J, Dai Z, Dong C (2024) IMPA2 promotes basal-like breast cancer aggressiveness by a MYC-mediated positive feedback loop. Cancer Lett 582:216527. https:\/\/doi.org\/10.1016\/j.canlet.2023.216527","journal-title":"Cancer Lett"},{"key":"5750_CR66","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-62430-5","volume":"16","author":"A Lluch","year":"2025","unstructured":"Lluch A, Latorre J, Espadas I, Oliveras-Canellas N, Moreno-Navarrete JM, Caballano-Infantes E, Sarker G, Malvido NF, Garrido-Gil P, Labandeira-Garcia JL, Nakaya N, Mora S, Chicano E, Lopez-Alcala J, Malagon MM, Martin-Montalvo A, Zhang B, Zhou Y, Domingos AI, Lopez M, Porschke J, Gomez-Serrano M, Szymanski W, Graumann J, Tomarev SI, Gonzalez-Garcia I, Fernandez-Real JM, Ortega FJ (2025) Defective olfactomedin-2 connects adipocyte dysfunction to obesity. Nat Commun 16:7154. https:\/\/doi.org\/10.1038\/s41467-025-62430-5","journal-title":"Nat Commun"},{"key":"5750_CR67","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.717917","volume":"11","author":"S Ma","year":"2021","unstructured":"Ma S, Duan L, Dong H, Ma X, Guo X, Liu J, Li G, Yu Y, Xu Y, Yuan G, Zhao X, Tian G, Zhai S, Pan Y, Zhang Y (2021) OLFML2A downregulation inhibits glioma proliferation through suppression of Wnt\/beta-catenin signaling. Front Oncol 11:717917. https:\/\/doi.org\/10.3389\/fonc.2021.717917","journal-title":"Front Oncol"},{"key":"5750_CR68","doi-asserted-by":"publisher","first-page":"8869510","DOI":"10.1155\/2024\/8869510","volume":"2024","author":"Z Jiang","year":"2024","unstructured":"Jiang Z, Zhou W, Tian X, Zou P, Li N, Zhang C, Li Y, Liu G (2024) A Protective role of canonical Wnt\/beta-catenin pathway in pathogenic bacteria-induced inflammatory responses. Mediators Inflamm 2024:8869510. https:\/\/doi.org\/10.1155\/2024\/8869510","journal-title":"Mediators Inflamm"},{"key":"5750_CR69","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.urolonc.2024.05.002","volume":"42","author":"S Zhu","year":"2024","unstructured":"Zhu S, He J, Yin L, Zhou J, Lian J, Ren Y, Zhang X, Yuan J, Wang G, Li X (2024) Matrix metalloproteinases targeting in prostate cancer. Urol Oncol 42:275\u2013287. https:\/\/doi.org\/10.1016\/j.urolonc.2024.05.002","journal-title":"Urol Oncol"},{"key":"5750_CR70","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-94072-0","volume":"11","author":"V Pecce","year":"2021","unstructured":"Pecce V, Verrienti A, Fiscon G, Sponziello M, Conte F, Abballe L, Durante C, Farina L, Filetti S, Paci P (2021) The role of FOSL1 in stem-like cell reprogramming processes. Sci Rep 11:14677. https:\/\/doi.org\/10.1038\/s41598-021-94072-0","journal-title":"Sci Rep"},{"key":"5750_CR71","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1517174","volume":"16","author":"M Cheng","year":"2025","unstructured":"Cheng M, Ding F, Li L, Dai C, Sun X, Xu J, Chen F, Li M, Li X (2025) Exploring the role of curcumin in mitigating oxidative stress to alleviate lipid metabolism disorders. Front Pharmacol 16:1517174. https:\/\/doi.org\/10.3389\/fphar.2025.1517174","journal-title":"Front Pharmacol"},{"key":"5750_CR72","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/s41392-020-00222-7","volume":"5","author":"Y Xie","year":"2020","unstructured":"Xie Y, Su N, Yang J, Tan Q, Huang S, Jin M, Ni Z, Zhang B, Zhang D, Luo F, Chen H, Sun X, Feng JQ, Qi H, Chen L (2020) FGF\/FGFR signaling in health and disease. Signal Transduct Target Ther 5:181. https:\/\/doi.org\/10.1038\/s41392-020-00222-7","journal-title":"Signal Transduct Target Ther"},{"key":"5750_CR73","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1016\/j.jid.2024.08.022","volume":"145","author":"G Cuesta-Margolles","year":"2025","unstructured":"Cuesta-Margolles G, Schlecht-Louf G, Bachelerie F (2025) ACKR3 in skin homeostasis, an overlooked player in the CXCR4\/CXCL12 axis. J Invest Dermatol 145:1039\u20131049. https:\/\/doi.org\/10.1016\/j.jid.2024.08.022","journal-title":"J Invest Dermatol"},{"key":"5750_CR74","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.fob.2012.05.001","volume":"2","author":"M Freitas","year":"2012","unstructured":"Freitas M, Baldeiras I, Proen\u00e7a T, Alves V, Mota Pinto A, Sarmento-Ribeiro A (2012) Oxidative stress adaptation in aggressive prostate cancer may be counteracted by the reduction of glutathione reductase. FEBS Open Bio 2:119\u2013128. https:\/\/doi.org\/10.1016\/j.fob.2012.05.001","journal-title":"FEBS Open Bio"},{"key":"5750_CR75","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13111340","volume":"13","author":"MAF Hussein","year":"2024","unstructured":"Hussein MAF, Lismont C, Costa CF, Li H, Claessens F, Fransen M (2024) Characterization of the peroxisomal proteome and redox balance in human prostate cancer cell lines. Antioxidants (Basel) 13:1340","journal-title":"Antioxidants (Basel)"},{"key":"5750_CR76","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115523","volume":"211","author":"N Li","year":"2023","unstructured":"Li N, Lin G, Zhang H, Sun J, Gui M, Liu Y, Li W, Zhan Z, Li Y, Pan S, Liu J, Tang J (2023) Lyn attenuates sepsis-associated acute kidney injury by inhibition of phospho-STAT3 and apoptosis. Biochem Pharmacol 211:115523. https:\/\/doi.org\/10.1016\/j.bcp.2023.115523","journal-title":"Biochem Pharmacol"},{"key":"5750_CR77","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.molcel.2021.01.033","volume":"81","author":"R Mukherjee","year":"2021","unstructured":"Mukherjee R, Vanaja KG, Boyer JA, Gadal S, Solomon H, Chandarlapaty S, Levchenko A, Rosen N (2021) Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis. Mol Cell 81:708-723 e5. https:\/\/doi.org\/10.1016\/j.molcel.2021.01.033","journal-title":"Mol Cell"},{"key":"5750_CR78","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2023-006890","author":"Z Wang","year":"2023","unstructured":"Wang Z, Li R, Hou N, Zhang J, Wang T, Fan P, Ji C, Zhang B, Liu L, Wang Y, Kong J, Yao Q, Duan J, Zhao G, Ling R, Zhang J (2023) PRMT5 reduces immunotherapy efficacy in triple-negative breast cancer by methylating KEAP1 and inhibiting ferroptosis. J Immunother Cancer. https:\/\/doi.org\/10.1136\/jitc-2023-006890","journal-title":"J Immunother Cancer"},{"key":"5750_CR79","doi-asserted-by":"publisher","first-page":"13516","DOI":"10.1073\/pnas.1311784110","volume":"110","author":"H Wei","year":"2013","unstructured":"Wei H, Wang B, Miyagi M, She Y, Gopalan B, Huang DB, Ghosh G, Stark GR, Lu T (2013) PRMT5 dimethylates R30 of the p65 subunit to activate NF-kappaB. Proc Natl Acad Sci U S A 110:13516\u201313521. https:\/\/doi.org\/10.1073\/pnas.1311784110","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5750_CR80","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/onc.2016.199","volume":"36","author":"YK Banasavadi-Siddegowda","year":"2017","unstructured":"Banasavadi-Siddegowda YK, Russell L, Frair E, Karkhanis VA, Relation T, Yoo JY, Zhang J, Sif S, Imitola J, Baiocchi R, Kaur B (2017) PRMT5-PTEN molecular pathway regulates senescence and self-renewal of primary glioblastoma neurosphere cells. Oncogene 36:263\u2013274. https:\/\/doi.org\/10.1038\/onc.2016.199","journal-title":"Oncogene"},{"key":"5750_CR81","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10030492","volume":"10","author":"E Obrador","year":"2021","unstructured":"Obrador E, Salvador-Palmer R, Jihad-Jebbar A, L\u00f3pez-Blanch R, Dellinger TH, Dellinger RW, Estrela JM (2021) Pterostilbene in cancer therapy. Antioxidants 10:492","journal-title":"Antioxidants"},{"key":"5750_CR82","doi-asserted-by":"publisher","DOI":"10.3390\/pr10020415","volume":"10","author":"M Sohel","year":"2022","unstructured":"Sohel M, Biswas P, Al Amin M, Hossain MA, Sultana H, Dey D, Aktar S, Setu A, Khan MS, Paul P, Islam MN, Rahman MA, Kim B, Al Mamun A (2022) Genistein, a potential phytochemical against breast cancer treatment-insight into the molecular mechanisms. Processes 10:415","journal-title":"Processes"},{"key":"5750_CR83","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics17091219","volume":"17","author":"I Conesa","year":"2025","unstructured":"Conesa I, Navarro-Orcajada S, Vidal-Sanchez FJ, Torralba-Anton E, Carrion-Espinosa M, Matencio A, Lopez-Nicolas JM (2025) Pinostilbene as a potential cytotoxic agent in cancer cell lines: improvement of solubility and stability by cyclodextrin encapsulation. Pharmaceutics 17:1219. https:\/\/doi.org\/10.3390\/pharmaceutics17091219","journal-title":"Pharmaceutics"},{"key":"5750_CR84","doi-asserted-by":"publisher","first-page":"12360","DOI":"10.3390\/ijms232012360","volume":"23","author":"MA Pawlicka","year":"2022","unstructured":"Pawlicka MA, Zmorzynski S, Popek-Marciniec S, Filip AA (2022) The effects of genistein at different concentrations on MCF-7 breast cancer cells and BJ dermal fibroblasts. Int J Mol Sci 23:12360. https:\/\/doi.org\/10.3390\/ijms232012360","journal-title":"Int J Mol Sci"},{"key":"5750_CR85","doi-asserted-by":"publisher","first-page":"1362s","DOI":"10.1093\/jn\/131.4.1362S","volume":"131","author":"KD Setchell","year":"2001","unstructured":"Setchell KD, Brown NM, Desai P, Zimmer-Nechemias L, Wolfe BE, Brashear WT, Kirschner AS, Cassidy A, Heubi JE (2001) Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements. J Nutr 131:1362s-s1375. https:\/\/doi.org\/10.1093\/jn\/131.4.1362S","journal-title":"J Nutr"},{"key":"5750_CR86","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.2174\/187152012803833107","volume":"12","author":"Z Yang","year":"2012","unstructured":"Yang Z, Kulkarni K, Zhu W, Hu M (2012) Bioavailability and pharmacokinetics of genistein: mechanistic studies on its ADME. Anticancer Agents Med Chem 12:1264\u20131280. https:\/\/doi.org\/10.2174\/187152012803833107","journal-title":"Anticancer Agents Med Chem"},{"key":"5750_CR87","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25215166","volume":"25","author":"Y Liu","year":"2020","unstructured":"Liu Y, You Y, Lu J, Chen X, Yang Z (2020) Recent advances in synthesis, bioactivity, and pharmacokinetics of pterostilbene, an important analog of resveratrol. Molecules 25:5166","journal-title":"Molecules"},{"key":"5750_CR88","doi-asserted-by":"publisher","first-page":"2122","DOI":"10.1002\/mnfr.201400244","volume":"58","author":"M Azzolini","year":"2014","unstructured":"Azzolini M, La Spina M, Mattarei A, Paradisi C, Zoratti M, Biasutto L (2014) Pharmacokinetics and tissue distribution of pterostilbene in the rat. Mol Nutr Food Res 58:2122\u20132132. https:\/\/doi.org\/10.1002\/mnfr.201400244","journal-title":"Mol Nutr Food Res"},{"key":"5750_CR89","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2021.131051","volume":"370","author":"V Agull\u00f3","year":"2022","unstructured":"Agull\u00f3 V, Garc\u00eda-Viguera C, Dom\u00ednguez-Perles R (2022) The use of alternative sweeteners (sucralose and stevia) in healthy soft-drink beverages, enhances the bioavailability of polyphenols relative to the classical caloric sucrose. Food Chem 370:131051. https:\/\/doi.org\/10.1016\/j.foodchem.2021.131051","journal-title":"Food Chem"},{"key":"5750_CR90","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/1386078","author":"X Yao","year":"2021","unstructured":"Yao X, Mei Y, Mao W (2021) Quercetin improves mitochondrial function and inflammation in H2O2-induced oxidative stress damage in the gastric mucosal epithelial cell by regulating the PI3K\/AKT signaling pathway. Evid Based Complement Alternat Med. https:\/\/doi.org\/10.1155\/2021\/1386078","journal-title":"Evid Based Complement Alternat Med"},{"key":"5750_CR91","doi-asserted-by":"publisher","first-page":"103","DOI":"10.2147\/JIR.S61471","volume":"7","author":"E Pomari","year":"2014","unstructured":"Pomari E, Stefanon B, Colitti M (2014) Effect of plant extracts on H2O2-induced inflammatory gene expression in macrophages. J Inflamm Res 7:103\u2013112. https:\/\/doi.org\/10.2147\/JIR.S61471","journal-title":"J Inflamm Res"},{"key":"5750_CR92","doi-asserted-by":"publisher","first-page":"3559","DOI":"10.3892\/mmr.2016.5690","volume":"14","author":"YL Wang","year":"2016","unstructured":"Wang YL, Sun GY, Zhang Y, He JJ, Zheng S, Lin JN (2016) Tormentic acid inhibits H2O2-induced oxidative stress and inflammation in rat vascular smooth muscle cells via inhibition of the NF-kappaB signaling pathway. Mol Med Rep 14:3559\u20133564. https:\/\/doi.org\/10.3892\/mmr.2016.5690","journal-title":"Mol Med Rep"},{"key":"5750_CR93","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202400662","volume":"68","author":"MA Tello-Palencia","year":"2024","unstructured":"Tello-Palencia MA, Yang T, Sularz O, Demers LE, Ma Y, Boycott C, Zhang HA, Lubecka-Gajewska K, Kumar S, Ramsey BS, Torregrosa-Allen S, Elzey BD, Lanman NA, Korthauer K, Stefanska B (2024) Pterostilbene targets hallmarks of aging in the gene expression landscape in blood of healthy rats. Mol Nutr Food Res 68:2400662. https:\/\/doi.org\/10.1002\/mnfr.202400662","journal-title":"Mol Nutr Food Res"},{"key":"5750_CR94","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.mito.2016.05.005","volume":"29","author":"MR de Oliveira","year":"2016","unstructured":"de Oliveira MR (2016) Evidence for genistein as a mitochondriotropic molecule. Mitochondrion 29:35\u201344. https:\/\/doi.org\/10.1016\/j.mito.2016.05.005","journal-title":"Mitochondrion"},{"key":"5750_CR95","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.jsbmb.2015.04.018","volume":"152","author":"AM Mahmoud","year":"2015","unstructured":"Mahmoud AM, Al-alem U, Ali MM, Bosland MC (2015) Genistein increases estrogen receptor beta expression in prostate cancer via reducing its promoter methylation. J Steroid Biochem Mol Biol 152:62\u201375. https:\/\/doi.org\/10.1016\/j.jsbmb.2015.04.018","journal-title":"J Steroid Biochem Mol Biol"},{"key":"5750_CR96","doi-asserted-by":"publisher","first-page":"41988","DOI":"10.18632\/oncotarget.16716","volume":"8","author":"EX Xue","year":"2017","unstructured":"Xue EX, Lin JP, Zhang Y, Sheng SR, Liu HX, Zhou YL, Xu H (2017) Pterostilbene inhibits inflammation and ROS production in chondrocytes by activating Nrf2 pathway. Oncotarget 8:41988\u201342000. https:\/\/doi.org\/10.18632\/oncotarget.16716","journal-title":"Oncotarget"},{"key":"5750_CR97","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/459165","volume":"2014","author":"DM Riche","year":"2014","unstructured":"Riche DM, Riche KD, Blackshear CT, McEwen CL, Sherman JJ, Wofford MR, Griswold ME (2014) Pterostilbene on metabolic parameters: a randomized, double-blind, and placebo-controlled trial. Evid Based Complement Alternat Med 2014:459165. https:\/\/doi.org\/10.1155\/2014\/459165","journal-title":"Evid Based Complement Alternat Med"},{"key":"5750_CR98","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1111\/nure.12044","volume":"71","author":"GP Nagaraju","year":"2013","unstructured":"Nagaraju GP, Zafar SF, El-Rayes BF (2013) Pleiotropic effects of genistein in metabolic, inflammatory, and malignant diseases. Nutr Rev 71:562\u2013572. https:\/\/doi.org\/10.1111\/nure.12044","journal-title":"Nutr Rev"},{"key":"5750_CR99","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201801386","volume":"63","author":"M Beetch","year":"2019","unstructured":"Beetch M, Lubecka K, Shen K, Flower K, Harandi-Zadeh S, Suderman M, Flanagan JM, Stefanska B (2019) Stilbenoid-mediated epigenetic activation of semaphorin 3A in breast cancer cells involves changes in dynamic interactions of DNA with DNMT3A and NF1C transcription factor. Mol Nutr Food Res 63:e1801386. https:\/\/doi.org\/10.1002\/mnfr.201801386","journal-title":"Mol Nutr Food Res"},{"key":"5750_CR100","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1001\/jamainternmed.2013.6536","volume":"173","author":"EL Richman","year":"2013","unstructured":"Richman EL, Kenfield SA, Chavarro JE, Stampfer MJ, Giovannucci EL, Willett WC, Chan JM (2013) Fat intake after diagnosis and risk of lethal prostate cancer and all-cause mortality. JAMA Intern Med 173:1318\u20131326. https:\/\/doi.org\/10.1001\/jamainternmed.2013.6536","journal-title":"JAMA Intern Med"},{"key":"5750_CR101","doi-asserted-by":"publisher","DOI":"10.1186\/s12940-021-00779-y","volume":"20","author":"E Salamanca-Fern\u00e1ndez","year":"2021","unstructured":"Salamanca-Fern\u00e1ndez E, Rodr\u00edguez-Barranco M, Amiano P, Delfrade J, Chirlaque MD, Colorado S, Guevara M, Jimenez A, Arrebola JP, Vela F, Olea N, Agudo A, S\u00e1nchez M-J (2021) Bisphenol-A exposure and risk of breast and prostate cancer in the Spanish European Prospective Investigation into Cancer and Nutrition study. Environ Health 20:88. https:\/\/doi.org\/10.1186\/s12940-021-00779-y","journal-title":"Environ Health"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-026-05750-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-026-05750-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-026-05750-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T07:55:39Z","timestamp":1792569339000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-026-05750-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,24]]},"references-count":101,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["5750"],"URL":"https:\/\/doi.org\/10.1007\/s11010-026-05750-4","relation":{},"ISSN":["1573-4919"],"issn-type":[{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,24]]},"assertion":[{"value":"2 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The Authors declare no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}