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The animal experimental protocol was approved by the Laboratory Animal Ethics Committee of Wenzhou Medical University (Approval No. wydw2023-0348). All animal procedures were conducted in compliance with the ARRIVE guidelines and the National Institutes of Health Guide for the Care and Use of Laboratory Animals. The animal facility license number was SYXK (Zhe) 2020-0014, and the animals (male C57BL\/6 mice, 8\u2011week\u2011old) were sourced from Vital River Laboratory Animal Technology Co., Ltd. (Production License: SCXK (Zhe) 2019-0001). All efforts were made to minimize animal suffering, and euthanasia was performed by isoflurane overdose followed by cervical dislocation. All animal experiments were designed in accordance with the principles of Replacement, Reduction, and Refinement. The chow-fed CYP2U1\n                      +\n                      group served as the within-experiment control, which allowed all four conditions to be compared within a single cohort and avoided the need for a separate control cohort.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable. This study does not involve human participants, human data, or human biological material.","order":3,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable. This manuscript does not contain any individual person\u2019s data in any form (including individual details, images, or videos).","order":4,"name":"Ethics","label":"Consent to publication","group":{"name":"EthicsHeading","label":"Declarations"}}]}}