{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:55:38Z","timestamp":1778979338381,"version":"3.51.4"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2012,5,18]],"date-time":"2012-05-18T00:00:00Z","timestamp":1337299200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1007\/s11011-012-9314-x","type":"journal-article","created":{"date-parts":[[2012,5,17]],"date-time":"2012-05-17T17:09:27Z","timestamp":1337274567000},"page":"551-557","source":"Crossref","is-referenced-by-count":28,"title":["Regional reduction in gray and white matter volume in brains of cirrhotic patients: voxel-based analysis of MRI"],"prefix":"10.1007","volume":"27","author":[{"given":"Motoh","family":"Iwasa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rumi","family":"Mifuji-Moroka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Moroka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinao","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiko","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esteban C.","family":"Gabazza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Takei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,5,18]]},"reference":[{"key":"9314_CR1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.20290","volume":"40","author":"B Ahl","year":"2004","unstructured":"Ahl B, Weissenborn K, van den Hoff J, Fischer-Wasels D, K\u00f6stler H, Hecker H, Burchert W (2004) Regional differences in cerebral blood flow and cerebral ammonia metabolism in patients with cirrhosis. Hepatology 40:73\u201379","journal-title":"Hepatology"},{"key":"9314_CR2","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neuroimage.2007.07.007","volume":"38","author":"J Ashburner","year":"2007","unstructured":"Ashburner J (2007) A first diffeomorphic image registration algorithm. NeuroImage 38:95\u2013113","journal-title":"NeuroImage"},{"key":"9314_CR3","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/ajg.2009.7","volume":"104","author":"JS Bajaj","year":"2009","unstructured":"Bajaj JS, Hafeezullah M, Zadvornova Y, Martin E, Schubert CM, Gibson DP, Hoffmann RG, Sanyal AJ, Heuman DM, Hammeke TA, Saeian K (2009) The effect of fatigue on driving skills in patients with hepatic encephalopathy. Am J Gastroenterol 104:898\u2013905","journal-title":"Am J Gastroenterol"},{"key":"9314_CR4","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1006\/nimg.2001.0848","volume":"14","author":"JC Baron","year":"2001","unstructured":"Baron JC, Ch\u00e9telat G, Desgranges B, Perchey G, Landeau B, de la Sayette V, Eustache F (2001) In vivo mapping of gray matter loss with voxel-based morphometry in mild Alzheimer\u2019s disease. NeuroImage 14:298\u2013309","journal-title":"NeuroImage"},{"key":"9314_CR5","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00259-007-0586-z","volume":"35","author":"C Boy","year":"2008","unstructured":"Boy C, Meyer PT, Kircheis G, Holschbach MH, Herzog H, Elmenhorst D, Kaiser HJ, Coenen HH, Haussinger D, Zilles K, Bauer A (2008) Cerebral A1 adenosine receptors (A1AR) in liver cirrhosis. Eur J Nucl Med Mol Imaging 35:589\u2013597","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"9314_CR6","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1053\/jhep.2002.31250","volume":"35","author":"P Ferenci","year":"2002","unstructured":"Ferenci P, Lockwood A, Mullen K, Tarter R, Weissenborn K, Blei AT (2002) Hepatic encephalopathy\u2013definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998. Hepatology 35:716\u2013721","journal-title":"Hepatology"},{"key":"9314_CR7","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.jhep.2010.12.008","volume":"55","author":"M Guevara","year":"2011","unstructured":"Guevara M, Baccaro ME, G\u00f3mez-Ans\u00f3n B, Frisoni G, Testa C, Torre A, Molinuevo JL, Rami L, Pereira G, Sotil EU, C\u00f3rdoba J, Arroyo V, Gin\u00e8s P (2011) Cerebral magnetic resonance imaging reveals marked abnormalities of brain tissue density in patients with cirrhosis without overt hepatic encephalopathy. J Hepatol 55:564\u2013573","journal-title":"J Hepatol"},{"key":"9314_CR8","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1046\/j.1460-9568.1998.00329.x","volume":"10","author":"C Hermenegildo","year":"1998","unstructured":"Hermenegildo C, Montoliu C, Llansola M, Mu\u00f1oz MD, Gaztelu JM, Mi\u00f1ana MD, Felipo V (1998) Chronic hyperammonemia impairs the glutamate-nitric oxide-cyclic GMP pathway in cerebellar neurons in culture and in the rat in vivo. Eur J Neurosci 10:3201\u20133209","journal-title":"Eur J Neurosci"},{"key":"9314_CR9","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s11011-005-2472-3","volume":"20","author":"M Iwasa","year":"2005","unstructured":"Iwasa M, Matsumura K, Nakagawa Y, Yamamoto M, Tanaka H, Horiike S, Ikoma J, Kaito M, Takeda K, Adachi Y (2005) Evaluation of cingulate gyrus blood flow in patients with liver cirrhosis. Metab Brain Dis 20:7\u201317","journal-title":"Metab Brain Dis"},{"key":"9314_CR10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.hepres.2004.07.001","volume":"30","author":"A Kato","year":"2004","unstructured":"Kato A, Kato M, Ishii H, Ichimiya Y, Suzuki K, Kawasaki H, Yamamoto SI, Kumashiro R, Yamamoto K, Kawamura N, Hayashi N, Matsuzaki S, Terano A, Okita K, Watanabe A (2004) Development of quantitative neuropsychological tests for diagnosis of subclinical hepatic encephalopathy in liver cirrhosis patients and establishment of diagnostic criteria-multicenter collaborative study in Japanese. Hepatol Res 30:71\u201378","journal-title":"Hepatol Res"},{"key":"9314_CR11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S1665-2681(19)31785-5","volume":"8","author":"A Lemberg","year":"2009","unstructured":"Lemberg A, Fern\u00e1ndez MA (2009) Hepatic encephalopathy, ammonia, glutamate, glutamine and oxidative stress. Ann Hepatol 8:95\u2013102","journal-title":"Ann Hepatol"},{"key":"9314_CR12","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1002\/hep.1840180508","volume":"18","author":"AH Lockwood","year":"1993","unstructured":"Lockwood AH, Murphy BW, Donnelly KZ, Mahl TC, Perini S (1993) Positron-emission tomographic localization of abnormalities of brain metabolism in patients with minimal hepatic encephalopathy. Hepatology 18:1061\u20131068","journal-title":"Hepatology"},{"key":"9314_CR13","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00234-004-1298-8","volume":"47","author":"S Mechtcheriakov","year":"2005","unstructured":"Mechtcheriakov S, Schocke M, Kugener A, Graziadei IW, Mattedi M, Hinterhuber H, Vogel W, Marksteiner J (2005) Chemical shift magnetic resonance spectroscopy of cingulate grey matter in patients with minimal hepatic encephalopathy. Neuroradiology 47:27\u201334","journal-title":"Neuroradiology"},{"key":"9314_CR14","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1111\/j.1478-3231.2011.02598.x","volume":"31","author":"F Moscucci","year":"2011","unstructured":"Moscucci F, Nardelli S, Pentassuglio I, Pasquale C, Ridola L, Merli M, Riggio O (2011) Previous overt hepatic encephalopathy rather than minimal hepatic encephalopathy impairs health-related quality of life in cirrhotic patients. Liver Int 31:1505\u20131510","journal-title":"Liver Int"},{"key":"9314_CR15","doi-asserted-by":"crossref","first-page":"326","DOI":"10.2337\/diabetes.55.02.06.db05-0520","volume":"55","author":"G Musen","year":"2006","unstructured":"Musen G, Lyoo IK, Sparks CR, Weinger K, Hwang J, Ryan CM, Jimerson DC, Hennen J, Renshaw PF, Jacobson AM (2006) Effects of type 1 diabetes on gray matter density as measured by voxel-based morphometry. Diabetes 55:326\u2013333","journal-title":"Diabetes"},{"key":"9314_CR16","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF02985102","volume":"18","author":"Y Nakagawa","year":"2004","unstructured":"Nakagawa Y, Matsumura K, Iwasa M, Kaito M, Adachi Y, Takeda K (2004) Single photon emission computed tomography and statistical parametric mapping analysis in cirrhotic patients with and without minimal hepatic encephalopathy. Ann Nucl Med 18:123\u2013129","journal-title":"Ann Nucl Med"},{"key":"9314_CR17","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.jhep.2005.09.019","volume":"44","author":"JH Nguyen","year":"2006","unstructured":"Nguyen JH, Yamamoto S, Steers J, Sevlever D, Lin W, Shimojima N, Castanedes-Casey M, Genco P, Golde T, Richelson E, Dickson D, McKinney M, Eckman CB (2006) Matrix metalloproteinase-9 contributes to brain extravasation and edema in fulminant hepatic failure mice. J Hepatol 44:1105\u20131114","journal-title":"J Hepatol"},{"key":"9314_CR18","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1023\/A:1020688925901","volume":"13","author":"MD Norenberg","year":"1998","unstructured":"Norenberg MD (1998) Astroglial dysfunction in hepatic encephalopathy. Metab Brain Dis 13:319\u2013335","journal-title":"Metab Brain Dis"},{"key":"9314_CR19","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1016\/j.neuroimage.2009.10.068","volume":"49","author":"JM Pereira","year":"2010","unstructured":"Pereira JM, Xiong L, Acosta-Cabronero J, Pengas G, Williams GB, Nestor PJ (2010) Registration accuracy for VBM studies varies according to region and degenerative disease grouping. NeuroImage 49:2205\u20132215","journal-title":"NeuroImage"},{"key":"9314_CR20","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1053\/j.gastro.2010.03.040","volume":"139","author":"R Rodrigo","year":"2010","unstructured":"Rodrigo R, Cauli O, Gomez-Pinedo U, Agusti A, Hernandez-Rabaza V, Garcia-Verdugo JM, Felipo V (2010) Hyperammonemia induces neuroinflammation that contributes to cognitive impairment in rats with hepatic encephalopathy. Gastroenterology 139:675\u2013684","journal-title":"Gastroenterology"},{"key":"9314_CR21","first-page":"1137","volume":"22","author":"A Rovira","year":"2001","unstructured":"Rovira A, Griv\u00e9 E, Pedraza S, Rovira A, Alonso J (2001) Magnetization transfer ratio values and proton MR spectroscopy of normal-appearing cerebral white matter in patients with liver cirrhosis. Am J Neuroradiol 22:1137\u20131142","journal-title":"Am J Neuroradiol"},{"key":"9314_CR22","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.3174\/ajnr.A1139","volume":"29","author":"A Rovira","year":"2008","unstructured":"Rovira A, Alonso J, C\u00f3rdoba J (2008) MR imaging findings in hepatic encephalopathy. Am J Neuroradiol 29:1612\u20131621","journal-title":"Am J Neuroradiol"},{"key":"9314_CR23","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1053\/jhep.2003.50477","volume":"38","author":"NJ Shah","year":"2003","unstructured":"Shah NJ, Neeb H, Zaitsev M, Steinhoff S, Kircheis G, Amunts K, H\u00e4ussinger D, Zilles K (2003) Quantitative T1 mapping of hepatic encephalopathy using magnetic resonance imaging. Hepatology 38:1219\u20131226","journal-title":"Hepatology"},{"key":"9314_CR24","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1471-4159.2012.07669.x","volume":"121","author":"M Skowro\u0144ska","year":"2012","unstructured":"Skowro\u0144ska M, Zieli\u0144ska M, W\u00f3jcik-Stanaszek L, Ruszkiewicz J, Milatovic D, Aschner M, Albrecht J (2012) Ammonia increases paracellular permeability of rat brain endothelial cells by a mechanism encompassing oxidative\/nitrosative stress and activation of matrix metalloproteinases. J Neurochem 121:125\u2013134","journal-title":"J Neurochem"},{"key":"9314_CR25","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1111\/j.1572-0241.2008.01788.x","volume":"103","author":"R Sugimoto","year":"2008","unstructured":"Sugimoto R, Iwasa M, Maeda M, Urawa N, Tanaka H, Fujita N, Kobayashi Y, Takeda K, Kaito M, Takei Y (2008) Value of the apparent diffusion coefficient for quantification of low-grade hepatic encephalopathy. Am J Gastroenterol 103:1413\u20131420","journal-title":"Am J Gastroenterol"},{"key":"9314_CR26","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.3174\/ajnr.A2200","volume":"31","author":"R Takahashi","year":"2010","unstructured":"Takahashi R, Ishii K, Miyamoto N, Yoshikawa T, Shimada K, Ohkawa S, Kakigi T, Yokoyama K (2010) Measurement of gray and white matter atrophy in dementia with Lewy bodies using diffeomorphic anatomic registration through exponentiated lie algebra: a comparison with conventional voxel-based morphometry. Am J Neuroradiol 31:1873\u20131878","journal-title":"Am J Neuroradiol"},{"key":"9314_CR27","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1023\/A:1011654210096","volume":"16","author":"K Weissenborn","year":"2001","unstructured":"Weissenborn K, Heidenreich S, Ennen J, R\u00fcckert N, Hecker H (2001) Attention deficits in minimal hepatic encephalopathy. Metab Brain Dis 16:13\u201319","journal-title":"Metab Brain Dis"},{"key":"9314_CR28","doi-asserted-by":"crossref","first-page":"9039","DOI":"10.1073\/pnas.1530467100","volume":"100","author":"H Yamasue","year":"2003","unstructured":"Yamasue H, Kasai K, Iwanami A, Ohtani T, Yamada H, Abe O, Kuroki N, Fukuda R, Tochigi M, Furukawa S, Sadamatsu M, Sasaki T, Aoki S, Ohtomo K, Asukai N, Kato N (2003) Voxel-based analysis of MRI reveals anterior cingulate gray-matter volume reduction in posttraumatic stress disorder due to terrorism. Proc Natl Acad Sci U S A 100:9039\u20139043","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-012-9314-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11011-012-9314-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-012-9314-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T20:57:55Z","timestamp":1561755475000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11011-012-9314-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,18]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["9314"],"URL":"https:\/\/doi.org\/10.1007\/s11011-012-9314-x","relation":{},"ISSN":["0885-7490","1573-7365"],"issn-type":[{"value":"0885-7490","type":"print"},{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,18]]}}}