{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T17:57:35Z","timestamp":1649181455082},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2012,7,27]],"date-time":"2012-07-27T00:00:00Z","timestamp":1343347200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1007\/s11011-012-9331-9","type":"journal-article","created":{"date-parts":[[2012,7,26]],"date-time":"2012-07-26T02:10:02Z","timestamp":1343268602000},"page":"453-458","source":"Crossref","is-referenced-by-count":6,"title":["Inhibition of acetylcholinesterase activity in brain and behavioral analysis in adult rats after chronic administration of fenproporex"],"prefix":"10.1007","volume":"27","author":[{"given":"Gislaine T.","family":"Rezin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giselli","family":"Scaini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela K.","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariane R.","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinara L.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa S.","family":"Constantino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro F.","family":"Deroza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando V.","family":"Ghedim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samira S.","family":"Valvassori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilson R.","family":"Resende","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o","family":"Quevedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra I.","family":"Zugno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio L.","family":"Streck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,7,27]]},"reference":[{"key":"9331_CR1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0166-2236(92)90100-M","volume":"15","author":"ME Appleyard","year":"1992","unstructured":"Appleyard ME (1992) Secreted acetylcholinesterase: non-classical aspects of a classical enzyme. Trends Neurosci 15:485\u2013490","journal-title":"Trends Neurosci"},{"key":"9331_CR2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2174\/1567205054367838","volume":"2","author":"CG Ballard","year":"2005","unstructured":"Ballard CG, Greig NH, Guillozet-Bongaarts AL, Enz A, Darvesh S (2005) Cholinesterases: Roles in the brain during health and disease. Curr Alzheimer Res 2:307\u2013318","journal-title":"Curr Alzheimer Res"},{"key":"9331_CR3","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1126\/science.7046051","volume":"217","author":"RT Bartus","year":"1982","unstructured":"Bartus RT, Dean RL, Beer B, Lippa AS (1982) The cholinergic hypothesis of geriatric memory dysfunction. Science 217:408\u2013414","journal-title":"Science"},{"key":"9331_CR4","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0074-7742(06)78007-2","volume":"78","author":"JA Berman","year":"2007","unstructured":"Berman JA, Talmage DA, Role LW (2007) Cholinergic Circuits and signaling in the pathophysiology of Schizophrenia. Int Rev Neurobiol 78:193\u2013223","journal-title":"Int Rev Neurobiol"},{"key":"9331_CR5","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/35007544","volume":"404","author":"GA Bray","year":"2000","unstructured":"Bray GA, Tartaglia LA (2000) Medicinal strategies in the treatment of obesity. Nature 404:672\u2013677","journal-title":"Nature"},{"key":"9331_CR6","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/jat\/23.3.187","volume":"23","author":"JT Cody","year":"1999","unstructured":"Cody JT, Valtier S, Stillman S (1999) Amphetamine and fenproporex levels following multidose administration of fenproporex. J Anal Toxicol 23:187\u2013194","journal-title":"J Anal Toxicol"},{"key":"9331_CR7","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1139\/y86-122","volume":"64","author":"RT Coutts","year":"1986","unstructured":"Coutts RT, Nazarali AJ, Baker GB, Pasutto FM (1986) Metabolism and disposition of N-(2-cyanoethyl)-amphetamine (fenproporex) and amphetamine: study in the rat brain. Can J Physiol Pharmacol 64:724\u2013728","journal-title":"Can J Physiol Pharmacol"},{"key":"9331_CR8","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.tins.2006.01.003","volume":"29","author":"SJ Cragg","year":"2006","unstructured":"Cragg SJ (2006) Meaningful silences: How dopamine listens to the ACh pause. Trends Neurosci 29:125\u2013131","journal-title":"Trends Neurosci"},{"key":"9331_CR9","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1006\/phrs.2000.0678","volume":"42","author":"A Das","year":"2000","unstructured":"Das A, Kapoor K, Sayeepriyadarshini AT, Dikshit M, Palit G, Nath C (2000) Immobilization stress-induced changes in acetylcholinesterase activity and cognitive function in mice. Pharmacol Res 42:213\u2013217","journal-title":"Pharmacol Res"},{"key":"9331_CR10","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","volume":"7","author":"GI Ellman","year":"1961","unstructured":"Ellman GI, Courtney KD, Andres V Jr, Feather-Stone RM (1961) A New and Rapid Colorimetric Determination of Acetylcholinesterase Activity. Biochem Pharmacol 7:88\u201395","journal-title":"Biochem Pharmacol"},{"key":"9331_CR11","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fnmol.2012.00030","volume":"5","author":"A Gilboa-Geffen","year":"2012","unstructured":"Gilboa-Geffen A, Hartmann G, Soreq H (2012) Stressing hematopoiesis and immunity: an acetylcholinesterase window into nervous and immune system interactions. Front Mol Neurosci 5:30. doi: 10.3389\/fnmol.2012.00030","journal-title":"Front Mol Neurosci"},{"key":"9331_CR12","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.pneurobio.2004.09.006","volume":"74","author":"C Gotti","year":"2004","unstructured":"Gotti C, Clementi F (2004) Neuronal nicotinic receptors: From structure to pathology. Prog Neurobiol 74:363\u2013396","journal-title":"Prog Neurobiol"},{"key":"9331_CR13","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1046\/j.1432-1327.1999.00693.x","volume":"264","author":"D Grisaru","year":"1999","unstructured":"Grisaru D, Sternfeld M, Eldor A, Glick D, Soreq H (1999) Structural roles of acetylcholinesterase variants in biology and pathology. Eur J Biochem 264:672\u2013686","journal-title":"Eur J Biochem"},{"key":"9331_CR14","doi-asserted-by":"crossref","first-page":"506","DOI":"10.2174\/092986709787315568","volume":"16","author":"T Gurevich-Panigrahi","year":"2009","unstructured":"Gurevich-Panigrahi T, Panigrahi S, Wiechec E, Los M (2009) Obesity: Pathophysiology and Clinical Management. Curr Med Chem 16:506\u2013521","journal-title":"Curr Med Chem"},{"key":"9331_CR15","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0891-0618(01)00101-6","volume":"22","author":"TM Hyde","year":"2001","unstructured":"Hyde TM, Crook JM (2001) Cholinergic systems and schizophrenia: Primary pathology or epiphenomena? J Chem Neuroanat 22:53\u201363","journal-title":"J Chem Neuroanat"},{"key":"9331_CR16","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0891-5849(94)00115-Z","volume":"18","author":"A Klegeris","year":"1995","unstructured":"Klegeris A, Korkina LG, Greenfield SA (1995) A possible interaction between acetylcholinesterase and dopamine molecules during autoxidation of the amine. Free Radic Biol Med 18:223\u2013230","journal-title":"Free Radic Biol Med"},{"key":"9331_CR17","doi-asserted-by":"crossref","unstructured":"Kleijn J, Wiskerke J, Cremers TI, Schoffelmeer AN, Westerink BH, Pattij T (2012) Effects of amphetamine on dopamine release in the rat nucleus accumbens shell region depend on cannabinoid CB1 receptor activation. Neurochem Int. Mar 10. [Epub ahead of print]","DOI":"10.1016\/j.neuint.2012.03.002"},{"key":"9331_CR18","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0378-4347(99)00497-1","volume":"738","author":"T Kraemer","year":"2000","unstructured":"Kraemer T, Theis GA, Weber AA, Maurer HH (2000) Studies on the metabolism and toxicological detection of the amphetamine-like anorectic fenproporex in human urine by gas chromatography-mass spectrometry and fluorescence polarization immunoassay. J Chromatogr B 738:107\u2013118","journal-title":"J Chromatogr B"},{"key":"9331_CR19","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1046\/j.1471-4159.1997.68052032.x","volume":"68","author":"R Kuczenski","year":"1997","unstructured":"Kuczenski R, Segal DS (1997) Effects of methylphenidate on extracellular dopamine, serotonin, and norepinephrine: Comparison with amphetamine. J Neurochem 68:2032\u20132037","journal-title":"J Neurochem"},{"key":"9331_CR20","first-page":"876","volume":"296","author":"R Kuczenski","year":"2001","unstructured":"Kuczenski R, Segal DS (2001) Locomotor effects of acute and repeated threshold doses of amphetamine and methylphenidate: Relative roles of dopamine and norepinephrine. J Pharmacol Exper Ther 296:876\u2013883","journal-title":"J Pharmacol Exper Ther"},{"key":"9331_CR21","doi-asserted-by":"crossref","first-page":"7264","DOI":"10.1523\/JNEUROSCI.22-16-07264.2002","volume":"22","author":"R Kuczenski","year":"2002","unstructured":"Kuczenski R, Segal DS (2002) Exposure of adolescent rats to oral methylphenidate: Preferential effects on extracellular norepinephrine and absence of sensitization and cross-sensitization to methamphetamine. J Neurosci 22:7264\u20137271","journal-title":"J Neurosci"},{"key":"9331_CR22","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1212\/WNL.52.4.691","volume":"52","author":"DE Kuhl","year":"1999","unstructured":"Kuhl DE, Koeppe RA, Minoshima S, Snyder SE, Ficaro EP, Foster NL, Frey KA, Kilbourn MR (1999) In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer\u2019s disease. Neurology 52:691\u2013699","journal-title":"Neurology"},{"key":"9331_CR23","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1523\/JNEUROSCI.19-04-01484.1999","volume":"19","author":"MJ LaVoie","year":"1999","unstructured":"LaVoie MJ, Hastings TG (1999) Dopamine quinone formation and protein modification associated with the striatal neurotoxicity of methamphetamine: evidence against a role for extracellular dopamine. J Neurosci 19:1484\u20131491","journal-title":"J Neurosci"},{"key":"9331_CR24","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1006\/taap.1999.8693","volume":"158","author":"J Liu","year":"1999","unstructured":"Liu J, Olivier K, Pope CN (1999) Comparative neurochemical effects of repeated methyl parathion or chlorpyrifos exposures in neonatal and adult rats. Toxicol Appl Pharmacol 158:186\u2013196","journal-title":"Toxicol Appl Pharmacol"},{"key":"9331_CR25","doi-asserted-by":"crossref","unstructured":"Lowry OH, Rosebough NG, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265\u2013275","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"9331_CR26","first-page":"1025","volume":"29","author":"R Mattei","year":"1996","unstructured":"Mattei R, Carlini EA (1996) Acomparative study of the anorectic and behavioral effects of fenproporex on male and female rats. Braz J Med Biol Res 29:1025\u20131030","journal-title":"Braz J Med Biol Res"},{"key":"9331_CR27","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0079-6123(03)45004-8","volume":"145","author":"MM Mesulam","year":"2004","unstructured":"Mesulam MM (2004) The cholinergic innervation of the human cerebral cortex. Progr Brain Res 145:67\u201378","journal-title":"Progr Brain Res"},{"key":"9331_CR28","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1006\/taap.1996.0003","volume":"136","author":"D Milatovic","year":"1996","unstructured":"Milatovic D, Dettbarn WD (1996) Modification of acetylcholinesterase during adaptation to chronic, subacute paraoxon application in rat. Toxicol Appl Pharmacol 136:20\u201328","journal-title":"Toxicol Appl Pharmacol"},{"key":"9331_CR29","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1006\/taap.1997.8354","volume":"149","author":"VC Moser","year":"1998","unstructured":"Moser VC, Padilla S (1998) Age- and gender-related differences in the time course of behavioral and biochemical effects produced by oral chlorpyrifos in rats. Toxicol Appl Pharmacol 149:107\u2013119","journal-title":"Toxicol Appl Pharmacol"},{"key":"9331_CR30","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/oby.2007.14","volume":"16","author":"N Moussavi","year":"2008","unstructured":"Moussavi N, Gavino V, Receveur O (2008) Could the Quality of Dietary Fat, and Not Just Its Quantity, Be Related to Risk of Obesity? Obesity 16:7\u201315","journal-title":"Obesity"},{"key":"9331_CR31","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.2174\/092986707782023217","volume":"14","author":"A Musial","year":"2007","unstructured":"Musial A, Bajda M, Malawska B (2007) Recent developments in cholinesterases inhibitors for Alzheimer\u2019s disease treatment. Curr Med Chem 14:2654\u20132679","journal-title":"Curr Med Chem"},{"key":"9331_CR32","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s002590050369","volume":"26","author":"H Namba","year":"1999","unstructured":"Namba H, Iyo M, Fukushi K, Shinotoh H, Nagatsuka S, Suhara T, Sudo Y, Suzuki K, Irie T (1999) Human cerebral acetylcholinesterase activity measured with positron emission tomography: procedure, normal values and effect of age. Eur J Nucl Med 26:135\u2013143","journal-title":"Eur J Nucl Med"},{"key":"9331_CR33","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1046\/j.1471-4159.2001.00179.x","volume":"76","author":"G Page","year":"2001","unstructured":"Page G, Peeters M, Najimi M, Maloteaux JM, Hermans E (2001) Modulation of the neuronal dopamine transporter activity by the metabotropic glutamate receptor mGluR5 in rat striatal synaptosomes through phosphorylation mediated processes. J Neurochem 76:1282\u20131290","journal-title":"J Neurochem"},{"key":"9331_CR34","doi-asserted-by":"crossref","unstructured":"Rezin GT, Jeremias IC, Ferreira GK, Cardoso MR, Morais MO, Gomes LM, Martinello OB, Valvassori SS, Quevedo J, Streck EL (2011) Brain energy metabolism is activated after acute and chronic administration of fenproporex in young rats. Int J Dev Neurosci 29:937\u2013942","DOI":"10.1016\/j.ijdevneu.2011.06.007"},{"key":"9331_CR35","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0165-0173(86)90002-0","volume":"11","author":"TE Robinson","year":"1986","unstructured":"Robinson TE, Becker JB (1986) Enduring changes in brain and behavior produced by chronic amphetamine administration: a review and evaluation of animal models of amphetamine psychosis. Brain Res Rev 11:157\u2013198","journal-title":"Brain Res Rev"},{"key":"9331_CR36","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1006\/nlme.1999.3910","volume":"72","author":"R Roesler","year":"1999","unstructured":"Roesler R, Vianna MR, De-Paris F, J Q (1999) Memory-enhancing treatments do not reverse the impairment of inhibitory avoidance retention induced by NMDA receptor blockade. Neurobiol Learn Mem 72:252\u2013258","journal-title":"Neurobiol Learn Mem"},{"key":"9331_CR37","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nrn1588","volume":"6","author":"M Sarter","year":"2005","unstructured":"Sarter M, Parikh V (2005) Choline transporters, cholinergic transmission and cognition. Nat Rev Neurosci 6:48\u201356","journal-title":"Nat Rev Neurosci"},{"key":"9331_CR38","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1023\/A:1007500424392","volume":"25","author":"MRC Schetinger","year":"2000","unstructured":"Schetinger MRC, Porto NM, Moretto MB, Morsch VM, Rocha JBT, Vieira V, Moro F, Neis RT, Bittencourt S, Bonacorso HG, Zanatta N (2000) New benzodiazepines alter acetylcholinesterase and ATP-Dase activities. Neurochem Res 25:949\u2013955","journal-title":"Neurochem Res"},{"key":"9331_CR39","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.coph.2005.01.014","volume":"5","author":"I Silman","year":"2005","unstructured":"Silman I, Sussman JL (2005) Acetylcholinesterase: \u2018classical\u2019 and \u2018non-classical\u2019 functions and pharmacology. Curr Opin Pharmacol 5:293\u2013302","journal-title":"Curr Opin Pharmacol"},{"key":"9331_CR40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0074-7742(05)64001-9","volume":"64","author":"J Smythies","year":"2005","unstructured":"Smythies J (2005) Section I: The cholinergic system. Int Rev Neurobiol 64:1\u2013122","journal-title":"Int Rev Neurobiol"},{"key":"9331_CR41","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1073\/pnas.86.4.1398","volume":"86","author":"MB Spina","year":"1989","unstructured":"Spina MB, Cohen G (1989) Dopamine turnover and glutathione oxidation: implications for Parkinson disease. Proc Natl Acad Sci USA 86:1398\u20131400","journal-title":"Proc Natl Acad Sci USA"},{"key":"9331_CR42","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0079-6123(03)45013-9","volume":"145","author":"M Steriade","year":"2004","unstructured":"Steriade M (2004) Acetylcholine systems and rhythmic activities during the waking\u2013sleep cycle. Prog Brain Res 145:179\u2013196","journal-title":"Prog Brain Res"},{"issue":"31","key":"9331_CR43","doi-asserted-by":"crossref","first-page":"11282","DOI":"10.1523\/JNEUROSCI.1810-11.2011","volume":"31","author":"MT Tse","year":"2011","unstructured":"Tse MT, Cantor A, Floresco SB (2011) Repeated amphetamine exposure disrupts dopaminergic modulation of amygdala-prefrontal circuitry and cognitive\/emotional functioning. J Neurosci 31(31):11282\u201394","journal-title":"J Neurosci"},{"key":"9331_CR44","unstructured":"United Nations International Narcotics Control Board (UNINCB). Report of the International Narcotics Control Board for 2007 (E\/INCB\/2007\/1). Available at: http:\/\/www.incb.org\/incb\/annual-report-2007.html ."},{"key":"9331_CR45","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1523\/JNEUROSCI.21-02-j0001.2001","volume":"2","author":"ND Volkow","year":"2001","unstructured":"Volkow ND, Wang G, Fowler JS, Logan J, Gerasimov M, Maynard L (2001) Therapeutic doses of oral methylphenidate significantly increases extracellular dopamine in the human brain. J Neurosci 2:121\u2013125","journal-title":"J Neurosci"},{"key":"9331_CR46","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.coph.2004.12.002","volume":"5","author":"S Wonnacott","year":"2005","unstructured":"Wonnacott S, Sidhpura N, Balfour DJ (2005) Nicotine: From molecular mechanisms to behavior. Curr Opin Pharmacol 5:53\u201359","journal-title":"Curr Opin Pharmacol"},{"key":"9331_CR47","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/0301-0082(91)90006-M","volume":"37","author":"N Woolf","year":"1991","unstructured":"Woolf N (1991) Cholinergic systems in mammalian brain and spinal cord. Prog Neurobiol 37:475\u2013524","journal-title":"Prog Neurobiol"},{"key":"9331_CR48","doi-asserted-by":"crossref","unstructured":"Zheng Q, Olivie, K, Won YK, Pope CN (2000) Comparative cholinergic neurotoxicity of oral chlorpyrifos exposures in preweanling and adult rats. Toxicol Sci 55:124\u2013132","DOI":"10.1093\/toxsci\/55.1.124"},{"key":"9331_CR49","doi-asserted-by":"crossref","first-page":"393","DOI":"10.2174\/187152708786927877","volume":"7","author":"J Zhu","year":"2008","unstructured":"Zhu J, Reith ME (2008) Role of the dopamine transporter in the action of psychostimulants, nicotine, and other drugs of abuse. CNS Neurol Disord Drug Targets 7:393\u2013409","journal-title":"CNS Neurol Disord Drug Targets"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-012-9331-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11011-012-9331-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-012-9331-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,23]],"date-time":"2022-01-23T01:07:08Z","timestamp":1642900028000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11011-012-9331-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,27]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["9331"],"URL":"https:\/\/doi.org\/10.1007\/s11011-012-9331-9","relation":{},"ISSN":["0885-7490","1573-7365"],"issn-type":[{"value":"0885-7490","type":"print"},{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,27]]}}}