{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:59:51Z","timestamp":1793314791445,"version":"4.5.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T00:00:00Z","timestamp":1384300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1007\/s11011-013-9446-7","type":"journal-article","created":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T21:28:00Z","timestamp":1384205280000},"page":"483-493","source":"Crossref","is-referenced-by-count":22,"title":["Glia activation and its role in oxidative stress"],"prefix":"10.1007","volume":"29","author":[{"given":"Olalekan Michael","family":"Ogundele","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adams Olalekan","family":"Omoaghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duyilemi Chris","family":"Ajonijebu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abiodun Ayodele","family":"Ojo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Temitope Deborah","family":"Fabiyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olayemi Joseph","family":"Olajide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah Tolulope","family":"Falode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip Adeyemi","family":"Adeniyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,11,13]]},"reference":[{"key":"9446_CR1","doi-asserted-by":"crossref","unstructured":"B\u00e9raud D, Hathaway HA, Trecki J, Chasovskikh S, Johnson DA, Johnson JA, Federoff HJ, Shimoji M, Mhyre TR, Maguire-Zeiss KA (2012) Microglial activation and antioxidant responses induced by the Parkinson\u2019s disease protein \u03b1-Synuclein. J Neuroimmune Pharmacol 8(1):94\u2013117","DOI":"10.1007\/s11481-012-9401-0"},{"key":"9446_CR2","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.2741\/4167","volume":"18","author":"B Campanini","year":"2013","unstructured":"Campanini B, Spyrakis F, Peracchi A, Mozzarelli A (2013) Serine racemase: a key player in neuron activity and in neuropathologies. Front Biosci 18:1112\u201328","journal-title":"Front Biosci"},{"issue":"581","key":"9446_CR3","first-page":"221","volume":"2007","author":"L Chunyan","year":"2007","unstructured":"Chunyan L, Pradeep KT, William EA (2007) Differences in Spike train variability in rat vasopressin and oxytocin neuronsand their relationship to synaptic activity. J Physiol 2007(581):221\u2013240","journal-title":"J Physiol"},{"issue":"4","key":"9446_CR4","doi-asserted-by":"crossref","first-page":"303","DOI":"10.2174\/157015912804499465","volume":"10","author":"A Contestabile","year":"2012","unstructured":"Contestabile A, Monti B, Polazzi E (2012) Neuronal-glial interactions define the role of nitric oxide in neural functional processes. Curr Neuropharmacol 10(4):303\u201310","journal-title":"Curr Neuropharmacol"},{"key":"9446_CR5","doi-asserted-by":"crossref","unstructured":"Devos SL, Miller TM (2013) Direct intraventricular delivery of drugs to the rodent central nervous system. J Vis Exp (75):e50326. doi: 10.3791\/50326","DOI":"10.3791\/50326"},{"key":"9446_CR6","doi-asserted-by":"crossref","unstructured":"Eid T, Tu N, Lee TS, Lai JC (2013) Regulation of astrocyte glutamine synthetase in epilepsy. Neurochem Int. doi: 10.1016\/j.neuint.2013.06.008","DOI":"10.1016\/j.neuint.2013.06.008"},{"issue":"1","key":"9446_CR7","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2174\/1874609811306010007","volume":"6","author":"FL Episcopo","year":"2013","unstructured":"Episcopo FL, Tirolo C, Testa N, Caniglia S, Morale MC, Marchetti B (2013) Reactive astrocytes are key players in nigrostriatal dopaminergic neurorepair in the mptp mouse model of Parkinson\u2019s disease: focus on endogenous neurorestoration. Curr Aging Sci 6(1):45\u201355","journal-title":"Curr Aging Sci"},{"issue":"18","key":"9446_CR8","doi-asserted-by":"crossref","first-page":"7742","DOI":"10.1523\/JNEUROSCI.3275-12.2013","volume":"33","author":"M Geissler","year":"2013","unstructured":"Geissler M, Gottschling C, Aguado A, Rauch U, Wetzel CH, Hatt H, Faissner A (2013) Primary hippocampal neurons, which lack four crucial extracellular matrix molecules, display abnormalities of synaptic structure and function and severe deficits in perineuronal net formation. J Neurosci 33(18):7742\u20137755. doi: 10.1523\/JNEUROSCI.3275-12.2013","journal-title":"J Neurosci"},{"issue":"7","key":"9446_CR9","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.jpain.2013.02.003","volume":"14","author":"J Hui","year":"2013","unstructured":"Hui J, Zhang ZJ, Zhang X, Shen Y, Gao YJ (2013) Repetitive hyperbaric oxygen treatment attenuates complete Freund\u2019s adjuvant-induced pain and reduces glia-mediated neuroinflammation in the spinal cord. J Pain 14(7):747\u201358","journal-title":"J Pain"},{"key":"9446_CR10","doi-asserted-by":"crossref","unstructured":"Jungenitz T, Radic T, Jedlicka P, Schwarzacher SW (2013) High-frequency stimulation induces gradual immediate early gene expression in maturing adult-generated hippocampal granule cells. Cereb Cortex. doi: 10.1093\/cercor\/bht035","DOI":"10.1093\/cercor\/bht035"},{"issue":"1","key":"9446_CR11","first-page":"23","volume":"143","author":"LI Khozha\u012d","year":"2013","unstructured":"Khozha\u012d LI, Otellin VA (2013) Reactive microglial changes in rat neocortex and hippocampus after exposure to acute perinatal hypoxia. Morfologiia 143(1):23\u20137","journal-title":"Morfologiia"},{"key":"9446_CR12","first-page":"OL1780","volume":"Suppl.58","author":"JH Kim","year":"2012","unstructured":"Kim JH, Choi JS, Lee BH (2012) PI3K\/Akt and MAPK pathways evoke activation of FoxO transcription factor to undergo neuronal apoptosis in brain of the silkworm Bombyx mori (Lepidoptera: Bombycidae). Cell Mol Biol (Noisy-le-grand) Suppl.58:OL1780\u2013OL1785","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"9446_CR13","doi-asserted-by":"crossref","unstructured":"Knolhoff AM, Nautiyal KM, Nemes P, Kalachikov S, Morozova I, Silver R, Sweedler JV (2013) Combining small-volume metabolomic and transcriptomic approaches for assessing brain chemistry. Anal Chem 85(6):3136\u201343. doi: 10.1021\/ac3032959","DOI":"10.1021\/ac3032959"},{"issue":"7","key":"9446_CR14","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/nn.3139","volume":"15","author":"P Knuckles","year":"2012","unstructured":"Knuckles P, Vogt MA, Lugert S, Milo M, Chong MM, Hautbergue GM, Wilson SA, Littman DR, Taylor V (2012) Drosha regulates neurogenesis by controlling neurogenin 2 expression independent of microRNAs. Nat Neurosci 15(7):962\u20139. doi: 10.1038\/nn.3139","journal-title":"Nat Neurosci"},{"issue":"22","key":"9446_CR15","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.lfs.2013.04.005","volume":"92","author":"JM Madeira","year":"2013","unstructured":"Madeira JM, Renschler CJ, Mueller B, Hashioka S, Gibson DL, Klegeris A (2013) Novel protective properties of auranofin: inhibition of human astrocyte cytotoxic secretions and direct neuroprotection. Life Sci 92(22):1072\u201380. doi: 10.1016\/j.lfs.2013.04.005","journal-title":"Life Sci"},{"key":"9446_CR16","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.1749-6632.1996.tb34449.x","volume":"777","author":"PJ Magistretti","year":"1996","unstructured":"Magistretti PJ, Pellerin L (1996) Cellular mechanisms of brain energy metabolism. Relevance to functional brain imaging and to neurodegenerative disorders. Ann N Y Acad Sci 777:380\u2013387, Issue Bio artificial Organs: Science, Medicine, and Technology","journal-title":"Ann N Y Acad Sci"},{"issue":"18","key":"9446_CR17","doi-asserted-by":"crossref","first-page":"7985","DOI":"10.1523\/JNEUROSCI.5874-12.2013","volume":"33","author":"D May","year":"2013","unstructured":"May D, Tress O, Seifert G, Willecke K (2013) Connexin47 protein phosphorylation and stability in oligodendrocytes depend on expression of Connexin43 protein in astrocytes. J Neurosci 33(18):7985\u201396. doi: 10.1523\/JNEUROSCI.5874-12.2013","journal-title":"J Neurosci"},{"key":"9446_CR18","doi-asserted-by":"crossref","unstructured":"Morte MI, Carreira BP, Machado V, Carmo A, Nunes-Correia I, Carvalho CM, Ara\u00fajo IM (2013) Evaluation of proliferation of neural stem cells in vitro and in vivo. Curr Protoc Stem Cell Biol. 2:Unit2D.14. doi: 10.1002\/9780470151808.sc02d14s24","DOI":"10.1002\/9780470151808.sc02d14s24"},{"issue":"5","key":"9446_CR19","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1111\/j.1528-1167.2012.03463.x","volume":"53","author":"BL Murphy","year":"2012","unstructured":"Murphy BL, Hofacer RD, Faulkner CN, Loepke AW, Danzer SC (2012) Abnormalities of granule cell dendritic structure are a prominent feature of the intrahippocampal kainic acid model of epilepsy despite reduced postinjury neurogenesis. Epilepsia 53(5):908\u201321. doi: 10.1111\/j.1528-1167.2012.03463.x","journal-title":"Epilepsia"},{"issue":"17","key":"9446_CR20","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.1523\/JNEUROSCI.0587-12.2012","volume":"32","author":"AA Mutso","year":"2012","unstructured":"Mutso AA, Radzicki D, Baliki MN, Huang L, Banisadr G, Centeno MV, Radulovic J, Martina M, Miller RJ, Apkarian AV (2012) Abnormalities in hippocampal functioning with persistent pain. J Neurosci 32(17):5747\u201356. doi: 10.1523\/JNEUROSCI.0587-12.2012","journal-title":"J Neurosci"},{"issue":"4","key":"9446_CR21","doi-asserted-by":"crossref","first-page":"e18303","DOI":"10.1371\/journal.pone.0018303","volume":"6","author":"I Nazarenko","year":"2011","unstructured":"Nazarenko I, Hedr\u00e9n A, Sj\u00f6din H, Orrego A, Andrae J, Afink GB, Nist\u00e9r M, Lindstr\u00f6m MS (2011) Brain abnormalities and glioma-like lesions in mice overexpressing the long isoform of PDGF-A in astrocytic cells. PLoS One 6(4):e18303","journal-title":"PLoS One"},{"issue":"21","key":"9446_CR22","doi-asserted-by":"crossref","first-page":"8714","DOI":"10.1073\/pnas.1218856110","volume":"110","author":"AM Nikolakopoulou","year":"2013","unstructured":"Nikolakopoulou AM, Dutta R, Chen Z, Miller RH, Trapp BD (2013) Activated microglia enhance neurogenesis via trypsinogen secretion. Proc Natl Acad Sci U S A 110(21):8714\u20139. doi: 10.1073\/pnas.1218856110","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9446_CR23","doi-asserted-by":"crossref","unstructured":"Oliva I, Fern\u00e1ndez M, Mart\u00edn ED (2013) Dopamine release regulation by astrocytes during cerebral ischemia. Neurobiol Dis. 58:231\u201341. doi: 10.1016\/j.nbd.2013.06.007","DOI":"10.1016\/j.nbd.2013.06.007"},{"key":"9446_CR24","first-page":"17","volume":"7","author":"JV Perederiy","year":"2013","unstructured":"Perederiy JV, Westbrook GL (2013) Structural plasticity in the dentate gyrus- revisiting a classic injury model. Front Neural Circ 7:17","journal-title":"Front Neural Circ"},{"key":"9446_CR25","doi-asserted-by":"crossref","unstructured":"Poluch S, Juliano SL (2013) Fine-tuning of neurogenesis is essential for the evolutionary expansion of the cerebral cortex. Cereb Cortex. doi: 10.1093\/cercor\/bht232","DOI":"10.1093\/cercor\/bht232"},{"key":"9446_CR26","doi-asserted-by":"crossref","unstructured":"Robins SC, Stewart I, McNay DE, Taylor V, Giachino C, Goetz M, Ninkovic J, Briancon N, Maratos-Flier E, Flier JS, Kokoeva MV, Placzek M (2013) \u0391-Tantacytes of the adult hypothalamic third ventricle includes distinct populations of FGF-responsive neural progenitors. Nature Communications 4, Article number: 2049, doi: 10.1038\/ncomms3049","DOI":"10.1038\/ncomms3049"},{"issue":"15","key":"9446_CR27","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1039\/c3lc50249j","volume":"13","author":"M Shi","year":"2013","unstructured":"Shi M, Majumdar D, Gao Y, Brewer BM, Goodwin CR, McLean JA, Li D, Webb DJ (2013) Glia co-culture with neurons in microfluidic platforms promotes the formation and stabilization of synaptic contacts. Lab Chip 13(15):3008\u201321. doi: 10.1039\/c3lc50249j","journal-title":"Lab Chip"},{"key":"9446_CR28","doi-asserted-by":"crossref","unstructured":"Skaper SD, Facci L, Giusti P (2013) Glia and mast cells as targets for palmitoylethanolamide, an anti-inflammatory and neuroprotective lipid mediator. Mol Neurobiol 48(2):340\u201352. doi: 10.1007\/s12035-013-8487-6","DOI":"10.1007\/s12035-013-8487-6"},{"key":"9446_CR29","doi-asserted-by":"crossref","unstructured":"Sykora P, Wilson DM 3rd, Bohr VA (2013) Base excision repair in the mammalian brain: implication for age related neurodegeneration. Mech Ageing Dev. doi: 10.1016\/j.mad.2013.04.005","DOI":"10.1016\/j.mad.2013.04.005"},{"key":"9446_CR30","doi-asserted-by":"crossref","unstructured":"Terazawa R, Akimoto N, Kato T, Itoh T, Fujita Y, Hamada N, Deguchi T, Iinuma M, Noda M, Nozawa Y, Ito M (2013) A kavalactone derivative inhibits lipopolysaccharide-stimulated iNOS induction and NO production through activation of Nrf2 signaling in BV2 microglial cells. Pharmacol Res. 71:34\u201343. doi: 10.1016\/j.phrs.2013.02.002","DOI":"10.1016\/j.phrs.2013.02.002"},{"key":"9446_CR31","doi-asserted-by":"crossref","unstructured":"Wang Y, Liu HK, Sch\u00fctz G (2013) Role of the nuclear receptor Tailless in adult neural stem cells. Mech Dev. doi: 10.1016\/j.mod.2013.02.001","DOI":"10.1016\/j.mod.2013.02.001"},{"issue":"1","key":"9446_CR32","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1746-1596-8-27","volume":"8","author":"Y Xiong","year":"2013","unstructured":"Xiong Y, Bai Y, Leong N, Laughlin TS, Rothberg PG, Xu H, Nong L, Zhao J, Dong Y, Li T (2013) Immunohistochemical detection of mutations in the epidermal growth factor receptor gene in lung adenocarcinomas using mutation-specific antibodies. Diagn Pathol 8(1):27\u20131","journal-title":"Diagn Pathol"},{"issue":"2","key":"9446_CR33","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.expneurol.2004.12.021","volume":"192","author":"Y Xu","year":"2013","unstructured":"Xu Y, Tamamaki N, Noda T, Kimura K, Itokazu Y, Matsumoto N, Dezawa M, Ide C (2013) Neurogenesis in the ependymal layer of the adult rat 3rd ventricle. Exp Neurol 192(2):251\u201364","journal-title":"Exp Neurol"},{"key":"9446_CR34","doi-asserted-by":"crossref","unstructured":"Zabel MK, Kirsch WM (2013) From development to dysfunction: Microglia and the complement cascade in CNS homeostasis. Ageing Res Rev. 12(3):749\u201356. doi: 10.1016\/j.arr.2013.02.001","DOI":"10.1016\/j.arr.2013.02.001"},{"key":"9446_CR35","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.neuroscience.2012.07.056","volume":"224","author":"ZZ Zhang","year":"2012","unstructured":"Zhang ZZ, Gong YY, Shi YH, Zhang W, Qin XH, Wu XW (2012) Valproate promotes survival of retinal ganglion cells in a rat model of optic nerve crush. Neuroscience 224:282\u201393. doi: 10.1016\/j.neuroscience.2012.07.056","journal-title":"Neuroscience"},{"key":"9446_CR36","doi-asserted-by":"crossref","unstructured":"Zhang HY, Wang ND, Song N, Xu HM, Shi LM, Jiang H, Xie JX (2013) 6-Hydroxydopamine promotes iron traffic in primary cultured astrocytes. Biometals. 26(5):705\u201314. doi: 10.1007\/s10534-013-9647-x","DOI":"10.1007\/s10534-013-9647-x"},{"key":"9446_CR37","doi-asserted-by":"crossref","unstructured":"Zhou Y, Xu Q, Li D, Zhao L, Wang Y, Liu M, Gu X, Liu Y (2012) Early neurogenesis during caudal spinal cord regeneration in adult Gekko japonicus. J Mol Histol. 44(3):291\u20137. doi: 10.1007\/s10735-012-9466-3","DOI":"10.1007\/s10735-012-9466-3"},{"issue":"52","key":"9446_CR38","doi-asserted-by":"crossref","first-page":"21522","DOI":"10.1073\/pnas.1216913110","volume":"109","author":"Y Zou","year":"2012","unstructured":"Zou Y, Corniola R, Leu D, Khan A, Sahbaie P, Chakraborti A, Clark DJ, Fike JR, Huang TT (2012) Extracellular superoxide dismutase is important for hippocampal neurogenesis and preservation of cognitive functions after irradiation. Proc Natl Acad Sci U S A 109(52):21522\u20137. doi: 10.1073\/pnas.1216913110","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-013-9446-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11011-013-9446-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-013-9446-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T22:21:58Z","timestamp":1559341318000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11011-013-9446-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,13]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["9446"],"URL":"https:\/\/doi.org\/10.1007\/s11011-013-9446-7","relation":{},"ISSN":["0885-7490","1573-7365"],"issn-type":[{"value":"0885-7490","type":"print"},{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,13]]}}}