{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:14:38Z","timestamp":1790644478595,"version":"4.1.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T00:00:00Z","timestamp":1416528000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1007\/s11011-014-9630-4","type":"journal-article","created":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T06:16:02Z","timestamp":1416550562000},"page":"739-746","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Low-grade chronic inflammation induces behavioral stereotypy in rats"],"prefix":"10.1007","volume":"30","author":[{"given":"Oytun","family":"Erba\u015f","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00fcseyin Serdar","family":"Akseki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00fcseyin","family":"Aktu\u011f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek","family":"Ta\u015fk\u0131ran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,11,21]]},"reference":[{"key":"9630_CR1","author":"D Aksoy","year":"2014","unstructured":"Aksoy D, Solmaz V, Ta\u015fk\u0131ran D, Erba\u015f O (2014) The association between seizure predisposition and inflammation in a rat model of fatty liver disease. Neurol Sci. doi: 10.1007\/s10072-014-1778-5","journal-title":"Neurol Sci"},{"key":"9630_CR2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jep.2004.10.003","volume":"97","author":"S Amos","year":"2005","unstructured":"Amos S, Abbah J, Chindo B, Edmond I, Binda L, Adzu B et al (2005) Neuropharmacological effects of the aqueous extract of Nauclea latifolia root bark in rats and mice. J Ethnopharmacol 97:53\u201357","journal-title":"J Ethnopharmacol"},{"key":"9630_CR3","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.jhep.2008.01.035","volume":"48","author":"I Bergheim","year":"2008","unstructured":"Bergheim I, Weber S, Vos M, Kramer S, Volynets V, Kaserouni S et al (2008) Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: role of endotoxin. J Hepatol 48:983\u2013992","journal-title":"J Hepatol"},{"key":"9630_CR4","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/1741-7015-11-200","volume":"11","author":"M Berk","year":"2013","unstructured":"Berk M, Williams LJ, Jacka FN, O\u2019Neil A, Pasco JA, Moylan et al (2013) So depression is an inflammatory disease, but where does the inflammation come from? BMC Med 11:200. doi: 10.1186\/1741-7015-11-20","journal-title":"BMC Med"},{"key":"9630_CR5","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254","journal-title":"Anal Biochem"},{"key":"9630_CR6","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1017\/S1461145709000315","volume":"12","author":"C Bresee","year":"2009","unstructured":"Bresee C, Rapaport MH (2009) Persistently increased serum soluble interleukin-2 receptors in continuously ill patients with schizophrenia. Int J Neuropsychopharmacol 12:861\u2013865","journal-title":"Int J Neuropsychopharmacol"},{"key":"9630_CR7","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jad.2008.12.001","volume":"116","author":"E Brietzke","year":"2009","unstructured":"Brietzke E, Stertz L, Fernandes BS, Kauer-Sant\u2019anna M, Mascarenhas M, Escosteguy Vargas A et al (2009) Comparison of cytokine levels in depressed, manic and euthymic patients with bipolar disorder. J Affect Disord 116:214\u2013217","journal-title":"J Affect Disord"},{"key":"9630_CR8","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1053\/jhep.2001.29628","volume":"34","author":"J Crespo","year":"2001","unstructured":"Crespo J, Cay\u00f3n A, Fern\u00e1ndez-Gil P, Hern\u00e1ndez-Guerra M, Mayorga M, Dom\u00ednguez-D\u00edez A, Fern\u00e1ndez-Escalante JC, Pons-Romero F (2001) Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients. Hepatology 34:1158\u20131163","journal-title":"Hepatology"},{"key":"9630_CR9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1749-6632.2008.03974.x","volume":"1153","author":"EG Araujo De","year":"2009","unstructured":"De Araujo EG, Da Silva GM, Dos Santos AA (2009) Neuronal cell survival: the role of interleukins. Ann N Y Acad Sci 1153:57\u201364","journal-title":"Ann N Y Acad Sci"},{"key":"9630_CR10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.4196\/kjpp.2009.13.2.71","volume":"13","author":"SM Dong","year":"2009","unstructured":"Dong SM, Kim YG, Heo J, Ji MK, Cho JW, Kwak BS (2009) YKP1447, A novel potential atypical antipsychotic agent. Korean J Physiol Pharmacol 13:71\u201378","journal-title":"Korean J Physiol Pharmacol"},{"key":"9630_CR11","doi-asserted-by":"crossref","unstructured":"Emanuela F, Grazia M, Marco de R, Maria Paola L, Giorgio F, Marco B (2012) Inflammation as a link between obesity and metabolic syndrome. J Nutr Metab 476380 doi: 10.1155\/2012\/476380","DOI":"10.1155\/2012\/476380"},{"key":"9630_CR12","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jss.2013.08.001","volume":"186","author":"O Erbas","year":"2014","unstructured":"Erbas O, Taskiran D (2014) Sepsis-induced changes in behavioral stereotypy in rats; involvement of TNF-\u03b1, oxidative stress and dopamine turnover. J Surg Res 186:262\u2013268","journal-title":"J Surg Res"},{"issue":"2","key":"9630_CR13","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.lfs.2014.03.035","volume":"103","author":"O Erba\u015f","year":"2014","unstructured":"Erba\u015f O, Solmaz V, Aksoy D, Yava\u015fo\u011flu A, Sa\u011fcan M, Ta\u015fk\u0131ran D (2014) Cholecalciferol (vitamin D 3) improves cognitive dysfunction and reduces inflammation in a rat fatty liver model of metabolic syndrome. Life Sci 103(2):68\u201372","journal-title":"Life Sci"},{"key":"9630_CR14","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1053\/j.gastro.2007.08.077","volume":"133","author":"A Fraser","year":"2007","unstructured":"Fraser A, Longnecker MP, Lawlor DA (2007) Prevalence of elevated alanine aminotransferase among US adolescents and associated factors: NHANES 1999\u20132004. Gastroenterology 133:1814\u20131820","journal-title":"Gastroenterology"},{"key":"9630_CR15","doi-asserted-by":"crossref","unstructured":"Hanisch UK, Quirion R (1995) Interleukin-2 as a neuroregulatory cytokine. Brain Res Brain Res Rev 21(3):246\u2013284","DOI":"10.1016\/0165-0173(95)00015-1"},{"key":"9630_CR16","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1172\/JCI117936","volume":"95","author":"GS Hotamisligil","year":"1995","unstructured":"Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM (1995) Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 95:2409\u20132415","journal-title":"J Clin Invest"},{"key":"9630_CR17","first-page":"46","volume":"40","author":"JM Hui","year":"2004","unstructured":"Hui JM, Hodge A, Farrell GC, Kench JG, Kriketos A, George J (2004) Beyond insulin resistance in NASH: TNF-alpha or adiponectin? Hepatology 40:46\u201354","journal-title":"Hepatology"},{"key":"9630_CR18","doi-asserted-by":"crossref","first-page":"s64","DOI":"10.1192\/bjp.184.47.s64","volume":"47","author":"D Kohen","year":"2004","unstructured":"Kohen D (2004) Diabetes mellitus and schizophrenia: historical perspective. Br J Psychiatry 47:s64\u2013s66","journal-title":"Br J Psychiatry"},{"key":"9630_CR19","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1080\/07315724.2008.10719744","volume":"27","author":"M Manco","year":"2008","unstructured":"Manco M, Bottazzo G, DeVito R, Marcellini M, Mingrone G, Nobili V (2008) Nonalcoholic fatty liver disease in children. J Am Coll Nutr 27:667\u2013676","journal-title":"J Am Coll Nutr"},{"key":"9630_CR20","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1016\/S0024-3205(99)00139-3","volume":"64","author":"KS Mark","year":"1999","unstructured":"Mark KS, Miller DW (1999) Increased permeability of primary cultured brain microvessel endothelial cell monolayers following TNF alpha exposure. Life Sci 64:1941\u20131953","journal-title":"Life Sci"},{"key":"9630_CR21","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.neubiorev.2008.10.005","volume":"33","author":"J McAfoose","year":"2009","unstructured":"McAfoose J, Baune BT (2009) Evidence for a cytokine model of cognitive function. Neurosci Biobehav Rev 33:355\u2013366","journal-title":"Neurosci Biobehav Rev"},{"key":"9630_CR22","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1038\/tp.2011.37","volume":"1","author":"DP McKernan","year":"2011","unstructured":"McKernan DP, Dennison U, Gaszner G, Cryan JF, Dinan TG (2011) Enhanced peripheral toll-like receptor responses in psychosis: further evidence of a pro-inflammatory phenotype. Transl Psychiatry 1:e36. doi: 10.1038\/tp.2011.37","journal-title":"Transl Psychiatry"},{"key":"9630_CR23","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.biopsych.2011.04.013","volume":"70","author":"BJ Miller","year":"2011","unstructured":"Miller BJ, Buckley P, Seabolt W, Mellor A, Kirkpatrick B (2011) Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects. Biol Psychiatry 70:663\u2013671","journal-title":"Biol Psychiatry"},{"key":"9630_CR24","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1440-1819.2009.01945.x","volume":"63","author":"A Monji","year":"2009","unstructured":"Monji A, Kato T, Kanba S (2009) Cytokines and schizophrenia: microglia hypothesis of schizophrenia. Psychiatry Clin Neurosci 63:257\u2013265","journal-title":"Psychiatry Clin Neurosci"},{"key":"9630_CR25","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.pnpbp.2011.12.002","volume":"42","author":"A Monji","year":"2013","unstructured":"Monji A, Kato TA, Mizoguchi Y, Horikawa H, Seki Y, Kasai M et al (2013) Neuroinflammation in schizophrenia especially focused on the role of microglia. Prog Neuropsychopharmacol Biol Psychiatry 42:115\u2013121","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"9630_CR26","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1254\/jphs.09292SC","volume":"112","author":"T Nishioku","year":"2010","unstructured":"Nishioku T, Matsumoto J, Dohgu S, Sumi N, Miyao K, Takata F et al (2010) Tumor necrosis factor-alpha mediates the blood\u2013brain barrier dysfunction induced by activated microglia in mouse brain microvascular endothelial cells. J Pharmacol Sci 112:251\u2013254","journal-title":"J Pharmacol Sci"},{"key":"9630_CR27","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.jhep.2008.02.011","volume":"48","author":"X Ouyang","year":"2008","unstructured":"Ouyang X, Cirillo P, Sautin Y, McCall S, Bruchette JL, Diehl AM et al (2008) Fructose consumption as a risk factor for non-alcoholic fatty liver disease. J Hepatol 48:993\u2013999","journal-title":"J Hepatol"},{"key":"9630_CR28","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1006\/exnr.2002.7871","volume":"174","author":"W Pan","year":"2002","unstructured":"Pan W, Kastin AJ (2002) TNF-\u03b1 transport across the blood\u2013brain barrier is abolished in receptor knockout mice. Exp Neurol 174:193\u2013200","journal-title":"Exp Neurol"},{"key":"9630_CR29","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.biopsych.2007.09.024","volume":"63","author":"S Potvin","year":"2008","unstructured":"Potvin S, Stip E, Sepehry AA, Gendron A, Bah R, Kouassi E (2008) Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review. Biol Psychiatry 63:801\u2013808","journal-title":"Biol Psychiatry"},{"key":"9630_CR30","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/glia.20467","volume":"55","author":"L Qin","year":"2007","unstructured":"Qin L, Wu X, Block ML, Liu Y, Breese GR, Hong JS (2007) Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia 55:453\u2013462","journal-title":"Glia"},{"key":"9630_CR31","doi-asserted-by":"crossref","first-page":"e64473","DOI":"10.1371\/journal.pone.0064473","volume":"8","author":"JS Rankin","year":"2013","unstructured":"Rankin JS, Zalcman SS, Zhu Y, Siegel A (2013) Short- and long-term effects of interleukin-2 treatment on the sensitivity of periadolescent female mice to interleukin-2 and dopamine uptake inhibitor. PLoS One 8:e64473","journal-title":"PLoS One"},{"key":"9630_CR32","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/sj.bjp.0702350","volume":"126","author":"C Reavill","year":"1999","unstructured":"Reavill C, Kettle A, Holland V, Riley G, Blackburn TP (1999) Attenuation of haloperidol induced catalepsy by a 5-HT2C-receptor antagonist. Br J Pharmacol 126:572\u2013574","journal-title":"Br J Pharmacol"},{"key":"9630_CR33","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-Hern\u00e1ndez H, Simental-Mend\u00eda LE, Rodr\u00edguez-Ram\u00edrez G, Reyes-Romero MA (2013) Obesity and inflammation: epidemiology, risk factors, and markers of inflammation. Int J Endocrinol 678159 doi: 10.1155\/2013\/678159","DOI":"10.1155\/2013\/678159"},{"key":"9630_CR34","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1054\/mehy.2000.1203","volume":"56","author":"MJ Schwarz","year":"2001","unstructured":"Schwarz MJ, M\u00fcller N, Riedel M, Ackenheil M (2001) The Th2-hypothesis of schizophrenia: a strategy to identify a subgroup of schizophrenia caused by immune mechanisms. Med Hypotheses 56:483\u2013486","journal-title":"Med Hypotheses"},{"key":"9630_CR35","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0306-9877(95)90062-4","volume":"45","author":"RS Smith","year":"1995","unstructured":"Smith RS, Maes M (1995) The macrophage-T-lymphocyte theory of schizophrenia: Additional evidence. Med Hypotheses 45:135\u2013141","journal-title":"Med Hypotheses"},{"key":"9630_CR36","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.biopsych.2008.10.018","volume":"65","author":"XQ Song","year":"2009","unstructured":"Song XQ, Lv LX, Li WQ, Hao YH, Zhao JP (2009) The interaction of nuclear factor-kappa B and cytokines is associated with schizophrenia. Biol Psychiatry 65:481\u2013488","journal-title":"Biol Psychiatry"},{"key":"9630_CR37","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1002\/hep.23122","volume":"50","author":"A Spruss","year":"2009","unstructured":"Spruss A, Kanuri G, Wagnerberger S (2009) Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice. Hepatology 50:1094\u20131104","journal-title":"Hepatology"},{"key":"9630_CR38","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1210\/er.2008-0009","volume":"29","author":"N Stefan","year":"2008","unstructured":"Stefan N, Kantartzis K, H\u00e4ring HU (2008) Causes and metabolic consequences of fatty liver. Endocr Rev 29:939\u2013960","journal-title":"Endocr Rev"},{"key":"9630_CR39","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1093\/jn\/138.8.1452","volume":"138","author":"S Thuy","year":"2008","unstructured":"Thuy S, Ladurner R, Volynets V, Wagner S, Strahl S, Konigsrainer A et al (2008) Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake. J Nutr 138:1452\u20131455","journal-title":"J Nutr"},{"key":"9630_CR40","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1002\/hep.1840060503","volume":"6","author":"H Tsukamoto","year":"1986","unstructured":"Tsukamoto H, Towner SJ, Ciofalo LM, French SW (1986) Ethanol-induced liver fibrosis in rats fed high fat diet. Hepatology 6:814\u2013822","journal-title":"Hepatology"},{"key":"9630_CR41","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1053\/gast.2002.31065","volume":"122","author":"L Valenti","year":"2002","unstructured":"Valenti L, Fracanzani AL, Dongiovanni P, Santorelli G, Branchi A, Taioli E, Fiorelli G, Fargion S (2002) Tumor necrosis factor alpha promoter polymorphisms and insulin resistance in nonalcoholic fatty liver disease. Gastroenterology 122:274\u2013280","journal-title":"Gastroenterology"},{"key":"9630_CR42","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0006-8993(01)02056-X","volume":"894","author":"JH Ye","year":"2001","unstructured":"Ye JH, Tao L, Zalcman SS (2001) Interleukin-2 modulates N-methyl-D-aspartate receptors of native mesolimbic neurons. Brain Res 894:241\u2013248","journal-title":"Brain Res"},{"key":"9630_CR43","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0006-8993(02)02740-3","volume":"944","author":"SS Zalcman","year":"2002","unstructured":"Zalcman SS (2002) Interleukin-2-induced increases in climbing behavior: inhibition by dopamine D-1 and D-2 receptor antagonists. Brain Res 944:157\u2013164","journal-title":"Brain Res"},{"issue":"1\u20132","key":"9630_CR44","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/0006-8993(94)90006-X","volume":"643","author":"S Zalcman","year":"1994","unstructured":"Zalcman S, Green-Johnson JM, Murray L, Nance DM, Dyck D, Anisman H, Greenberg AH (1994) Cytokine-specific central monoamine alterations induced by interleukin-1, \u22122 and \u22126. Brain Res 643(1\u20132):40\u201349","journal-title":"Brain Res"},{"key":"9630_CR45","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0006-8993(98)00904-4","volume":"811","author":"S Zalcman","year":"1998","unstructured":"Zalcman S, Murray L, Dyck DG, Greenberg AH, Nance DM (1998) Interleukin-2 and \u22126 induce behavioral-activating effects in mice. Brain Res 811:111\u2013121","journal-title":"Brain Res"},{"key":"9630_CR46","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0920-9964(01)00296-1","volume":"57","author":"XY Zhang","year":"2002","unstructured":"Zhang XY, Zhou DF, Zhang PY, Wu GY, Cao LY, Shen YC (2002) Elevated interleukin-2, interleukin-6 and interleukin-8 serum levels in neuroleptic-free schizophrenia: association with psychopathology. Schizophr Res 57:247\u2013258","journal-title":"Schizophr Res"},{"key":"9630_CR47","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1111\/j.1440-1746.2009.06144.x","volume":"25","author":"YJ Zhou","year":"2010","unstructured":"Zhou YJ, Li YY, Nie YQ, Yang H, Zhan Q, Huang J, Shi SL, Lai XB, Huang HL (2010) Influence of polygenetic polymorphisms on the susceptibility to non-alcoholic fatty liver disease of Chinese people. J Gastroenterol Hepatol 25:772\u2013777","journal-title":"J Gastroenterol Hepatol"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-014-9630-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11011-014-9630-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-014-9630-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T13:19:04Z","timestamp":1566047944000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11011-014-9630-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,21]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["9630"],"URL":"https:\/\/doi.org\/10.1007\/s11011-014-9630-4","relation":{},"ISSN":["0885-7490","1573-7365"],"issn-type":[{"value":"0885-7490","type":"print"},{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,21]]}}}