{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:21:57Z","timestamp":1773289317428,"version":"3.50.1"},"reference-count":127,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,9,23]],"date-time":"2015-09-23T00:00:00Z","timestamp":1442966400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1007\/s11011-015-9727-4","type":"journal-article","created":{"date-parts":[[2015,9,23]],"date-time":"2015-09-23T06:27:14Z","timestamp":1442989634000},"page":"135-156","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Molecular mechanisms of D-cycloserine in facilitating fear extinction: insights from RNAseq"],"prefix":"10.1007","volume":"31","author":[{"given":"Stefanie","family":"Malan-M\u00fcller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorren","family":"Fairbairn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willie M. U.","family":"Daniels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahjoubeh Jalali Sefid","family":"Dashti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward J.","family":"Oakeley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Altorfer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Kidd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soraya","family":"Seedat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junaid","family":"Gamieldien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00eean Megan Joanna","family":"Hemmings","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,9,23]]},"reference":[{"key":"9727_CR1","doi-asserted-by":"crossref","unstructured":"Anagnostaras SG, Gale GD, Fanselow MS (2001) Hippocampus and contextual fear conditioning: Recent controversies and advances. Hippocampus 11:8\u201317","DOI":"10.1002\/1098-1063(2001)11:1<8::AID-HIPO1015>3.0.CO;2-7"},{"key":"9727_CR2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jpsychores.2006.07.030","volume":"62","author":"L Arranz","year":"2007","unstructured":"Arranz L, Guayerbas N, De la FM (2007) Impairment of several immune functions in anxious women. J Psychosom Res 62:1\u20138","journal-title":"J Psychosom Res"},{"key":"9727_CR3","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.neubiorev.2004.03.004","volume":"28","author":"DM Bannerman","year":"2004","unstructured":"Bannerman DM, Rawlins JN, McHugh SB, Deacon RM, Yee BK, Bast T, Zhang WN, Pothuizen HH, Feldon J (2004) Regional dissociations within the hippocampus\u2013memory and anxiety. Neurosci Biobehav Rev 28:273\u2013283","journal-title":"Neurosci Biobehav Rev"},{"key":"9727_CR4","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.conb.2005.10.005","volume":"15","author":"M Barad","year":"2005","unstructured":"Barad M (2005) Fear extinction in rodents: basic insight to clinical promise. Curr Opin Neurobiol 15:710\u2013715","journal-title":"Curr Opin Neurobiol"},{"key":"9727_CR5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11064-010-0252-x","volume":"36","author":"HO Besedovsky","year":"2011","unstructured":"Besedovsky HO, del Rey A (2011) Central and peripheral cytokines mediate immune-brain connectivity. Neurochem Res 36:1\u20136","journal-title":"Neurochem Res"},{"key":"9727_CR6","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0887-6185(90)90015-2","volume":"4","author":"EB Blanchard","year":"1990","unstructured":"Blanchard EB (1990) Elevated basal levels of cardiovascular responses in Vietnam veterans with PTSD: a health problem in the making? J Anxiety Disord 4:233\u2013237","journal-title":"J Anxiety Disord"},{"key":"9727_CR7","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.annepidem.2005.03.009","volume":"16","author":"JA Boscarino","year":"2006","unstructured":"Boscarino JA (2006) Posttraumatic stress disorder and mortality among U.S. Army veterans 30 years after military service. Ann Epidemiol 16:248\u2013256","journal-title":"Ann Epidemiol"},{"key":"9727_CR8","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1097\/PSY.0b013e31817bccaf","volume":"70","author":"JA Boscarino","year":"2008","unstructured":"Boscarino JA (2008) A prospective study of PTSD and early-age heart disease mortality among Vietnam veterans: implications for surveillance and prevention. Psychosom Med 70:668\u2013676","journal-title":"Psychosom Med"},{"key":"9727_CR9","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.2337\/dc10-0296","volume":"33","author":"EJ Boyko","year":"2010","unstructured":"Boyko EJ, Jacobson IG, Smith B, Ryan MA, Hooper TI, Amoroso PJ, Gackstetter GD, Barrett-Connor E, Smith TC (2010) Risk of diabetes in U.S. military service members in relation to combat deployment and mental health. Diabetes Care 33:1771\u20131777","journal-title":"Diabetes Care"},{"key":"9727_CR10","author":"MS Breen","year":"2015","unstructured":"Breen MS, Maihofer AX, Glatt SJ, Tylee DS, Chandler SD, Tsuang MT, Risbrough VB, Baker DG, O\u2019Connor DT, Nievergelt CM, Woelk CH (2015) Gene networks specific for innate immunity define post-traumatic stress disorder. Mol Psychiatry. doi: 10.1038\/mp.2015.9","journal-title":"Mol Psychiatry"},{"key":"9727_CR11","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1097\/00006842-200107000-00011","volume":"63","author":"TC Buckley","year":"2001","unstructured":"Buckley TC, Kaloupek DG (2001) A meta-analytic examination of basal cardiovascular activity in posttraumatic stress disorder. Psychosom Med 63:585\u2013594","journal-title":"Psychosom Med"},{"key":"9727_CR12","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jaging.2013.03.002","volume":"27","author":"DP Burnes","year":"2013","unstructured":"Burnes DP, Burnette D (2013) Broadening the etiological discourse on Alzheimer\u2019s disease to include trauma and posttraumatic stress disorder as psychosocial risk factors. J Aging Stud 27:218\u2013224","journal-title":"J Aging Stud"},{"issue":"1","key":"9727_CR13","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.biopsych.2009.02.020","volume":"66","author":"D Carroll","year":"2009","unstructured":"Carroll D, Phillips AC, Thomas GN, Gale CR, Deary I, Batty GD (2009) Generalized anxiety disorder is associated with metabolic syndrome in the Vietnam experience study. Biol Psychiatry 66(1):91\u201393","journal-title":"Biol Psychiatry"},{"key":"9727_CR14","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0166-4328(96)00160-X","volume":"85","author":"F Chaouloff","year":"1997","unstructured":"Chaouloff F, Durand M, Mormede P (1997) Anxiety- and activity-related effects of diazepam and chlordiazepoxide in the rat light\/dark and dark\/light tests. Behav Brain Res 85:27\u201335","journal-title":"Behav Brain Res"},{"key":"9727_CR15","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/nrendo.2009.106","volume":"5","author":"GP Chrousos","year":"2009","unstructured":"Chrousos GP (2009) Stress and disorders of the stress system. Nat Rev Endocrinol 5:374\u2013381","journal-title":"Nat Rev Endocrinol"},{"key":"9727_CR16","doi-asserted-by":"crossref","unstructured":"Chu VT, Gottardo R, Raftery AE, Bumgarner RE, Yeung KY (2008) MeV+R: using MeV as a graphical user interface for\u00a0bioconductor applications in microarray analysis. Genome Biol 9:R118","DOI":"10.1186\/gb-2008-9-7-r118"},{"key":"9727_CR17","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1038\/nprot.2007.324","volume":"2","author":"MS Cline","year":"2007","unstructured":"Cline MS, Smoot M, Cerami E, Kuchinsky A, Landys N, Workman C, Christmas R, vila-Campilo I, Creech M, Gross B, Hanspers K, Isserlin R, Kelley R, Killcoyne S, Lotia S, Maere S, Morris J, Ono K, Pavlovic V, Pico AR, Vailaya A, Wang PL, Adler A, Conklin BR, Hood L, Kuiper M, Sander C, Schmulevich I, Schwikowski B, Warner GJ, Ideker T, Bader GD (2007) Integration of biological networks and gene expression data using Cytoscape. Nat Protoc 2:2366\u20132382","journal-title":"Nat Protoc"},{"key":"9727_CR18","doi-asserted-by":"crossref","unstructured":"Cohen H, Zohar J, Matar M (2003) The relevance of differential response to trauma in an animal model of posttraumatic stress disorder. Biol Psychiatry 53: 463\u2013473","DOI":"10.1016\/S0006-3223(02)01909-1"},{"key":"9727_CR19","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1097\/00001756-199707070-00004","volume":"8","author":"A Coogan","year":"1997","unstructured":"Coogan A, O\u2019Connor JJ (1997) Inhibition of NMDA receptor-mediated synaptic transmission in the rat dentate gyrus in vitro by IL-1 beta. Neuroreport 8:2107\u20132110","journal-title":"Neuroreport"},{"key":"9727_CR20","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature01322","volume":"420","author":"LM Coussens","year":"2002","unstructured":"Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420:860\u2013867","journal-title":"Nature"},{"key":"9727_CR21","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1176\/ajp.115.11.1025","volume":"115","author":"GE Crane","year":"1959","unstructured":"Crane GE (1959) Cycloserine as an antidepressant agent. Am J Psychiatry 115:1025\u20131026","journal-title":"Am J Psychiatry"},{"key":"9727_CR22","doi-asserted-by":"crossref","first-page":"D1104","DOI":"10.1093\/nar\/gks994","volume":"41","author":"AP Davis","year":"2013","unstructured":"Davis AP, Murphy CG, Johnson R, Lay JM, Lennon-Hopkins K, Saraceni-Richards C, Sciaky D, King BL, Rosenstein MC, Wiegers TC, Mattingly CJ (2013) The comparative toxicogenomics database: update 2013. Nucleic Acids Res 41:D1104\u2013D1114","journal-title":"Nucleic Acids Res"},{"key":"9727_CR23","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.biopsych.2012.02.033","volume":"71","author":"RA Kleine de","year":"2012","unstructured":"de Kleine RA, Hendriks GJ, Kusters WJ, Broekman TG, van Minnen A (2012) A randomized placebo-controlled trial of D-cycloserine to enhance exposure therapy for posttraumatic stress disorder. Biol Psychiatry 71:962\u2013968","journal-title":"Biol Psychiatry"},{"key":"9727_CR24","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s10880-012-9305-4","volume":"20","author":"EA Dedert","year":"2013","unstructured":"Dedert EA, Harper LA, Calhoun PS, Dennis MF, Beckham JC (2013) The impact of race on metabolic disease risk factors in women with and without posttraumatic stress disorder. J Clin Psychol Med Settings 20:46\u201355","journal-title":"J Clin Psychol Med Settings"},{"key":"9727_CR25","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1006\/brbi.1997.0508","volume":"11","author":"FS Dhabhar","year":"1997","unstructured":"Dhabhar FS, Mcewen BS (1997) Acute stress enhances while chronic stress suppresses cell-mediated immunity in vivo: a potential role for leukocyte trafficking. Brain Behav Immun 11:286\u2013306","journal-title":"Brain Behav Immun"},{"key":"9727_CR26","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11920-011-0240-0","volume":"14","author":"LE Egede","year":"2012","unstructured":"Egede LE, Dismuke CE (2012) Serious psychological distress and diabetes: a review of the literature. Curr Psychiatry Rep 14:15\u201322","journal-title":"Curr Psychiatry Rep"},{"key":"9727_CR27","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.4049\/jimmunol.181.3.1737","volume":"181","author":"IJ Elenkov","year":"2008","unstructured":"Elenkov IJ, Kvetnansky R, Hashiramoto A, Bakalov VK, Link AA, Zachman K, Crane M, Jezova D, Rovensky J, Dimitrov MA, Gold PW, Bonini S, Fleisher T, Chrousos GP, Wilder RL (2008) Low- versus high-baseline epinephrine output shapes opposite innate cytokine profiles: presence of Lewis- and Fischer-like neurohormonal immune phenotypes in humans? J Immunol 181:1737\u20131745","journal-title":"J Immunol"},{"key":"9727_CR28","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1023\/A:1007781909213","volume":"13","author":"EB Foa","year":"2000","unstructured":"Foa EB, Tolin DF (2000) Comparison of the PTSD symptom scale-interview version and the clinician-administered PTSD scale. J Trauma Stress 13:181\u2013191","journal-title":"J Trauma Stress"},{"key":"9727_CR29","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1207\/s15324796abm1201_3","volume":"12","author":"M Fredrikson","year":"1990","unstructured":"Fredrikson M, Matthews KA (1990) Cardiovascular responses to behavioural stress and hypertension: a meta-analytic review. Ann Behav Med 12:30\u201339","journal-title":"Ann Behav Med"},{"key":"9727_CR30","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0301-0511(76)90021-1","volume":"4","author":"M Fredrikson","year":"1976","unstructured":"Fredrikson M, Hugdahl K, Ohman A (1976) Electrodermal conditioning to potentially phobic stimuli in male and female subjects. Biol Psychol 4:305\u2013314","journal-title":"Biol Psychol"},{"key":"9727_CR31","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1101\/lm.528007","volume":"14","author":"A Gabriele","year":"2007","unstructured":"Gabriele A, Packard MG (2007) D-Cycloserine enhances memory consolidation of hippocampus-dependent latent extinction. Learn Mem 14:468\u2013471","journal-title":"Learn Mem"},{"key":"9727_CR32","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0162-3109(00)80302-1","volume":"49","author":"P Gasque","year":"2000","unstructured":"Gasque P, Dean YD, McGreal EP, VanBeek J, Morgan BP (2000) Complement components of the innate immune system in health and disease in the CNS. Immunopharmacology 49:171\u2013186","journal-title":"Immunopharmacology"},{"key":"9727_CR33","first-page":"421","volume-title":"Encyclopedia of stress","author":"A Georgiades","year":"2000","unstructured":"Georgiades A, Fredrikson M (2000) Hyperreactivity (cardiovascular). In: Fink G (ed) Encyclopedia of stress. Academic, San Diego, pp 421\u2013425"},{"key":"9727_CR34","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1176\/appi.ajp.158.8.1227","volume":"158","author":"TD Geracioti","year":"2001","unstructured":"Geracioti TD, Baker DG, Ekhator NN, West SA, Hill KK, Bruce AB, Schmidt D et al (2001) CSF norepinephrine concentrations in posttraumatic stress disorder. Am J Psychiatry 158:1227\u20131230","journal-title":"Am J Psychiatry"},{"key":"9727_CR35","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1001\/archpsyc.64.1.76","volume":"64","author":"E Geuze","year":"2007","unstructured":"Geuze E, Westenberg HG, Jochims A, de Kloet CS, Bohus M, Vermetten E, Schmahl C (2007) Altered pain processing in veterans with posttraumatic stress disorder. Arch Gen Psychiatry 64:76\u201385","journal-title":"Arch Gen Psychiatry"},{"key":"9727_CR36","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.jpsychires.2007.06.007","volume":"42","author":"E Geuze","year":"2008","unstructured":"Geuze E, Vermetten E, Ruf M, de Kloet CS, Westenberg HG (2008) Neural correlates of associative learning and memory in veterans with posttraumatic stress disorder. J Psychiatr Res 42:659\u2013669","journal-title":"J Psychiatr Res"},{"issue":"6982","key":"9727_CR37","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nature02426","volume":"428","author":"RA Gibbs","year":"2004","unstructured":"Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE et al (2004) Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature 428(6982):493\u2013521","journal-title":"Nature"},{"issue":"5","key":"9727_CR38","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1261\/rna.1947110","volume":"16","author":"A Git","year":"2010","unstructured":"Git A, Dvinge H, Salmon-Divon M, Osborne M, Kutter C, Hadfield J, Bertone P, Caldas C (2010) Systematic comparison of microarray profiling, real-time PCR, and next-generation sequencing technologies for measuring differential microRNA expression. RNA 16(5):991\u20131006","journal-title":"RNA"},{"key":"9727_CR39","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/ajmg.b.32167","volume":"162B","author":"SJ Glatt","year":"2013","unstructured":"Glatt SJ, Tylee DS, Chandler SD, Pazol J, Nievergelt CM, Woelk CH, Baker DG, Lohr JB, Kremen WS, Litz BT, Tsuang MT (2013) Blood-based gene-expression predictors of PTSD risk and resilience among deployed marines: a pilot study. Am J Med Genet B Neuropsychiatr Genet 162B:313\u2013326","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"9727_CR40","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.biopsych.2007.11.011","volume":"63","author":"AJ Guastella","year":"2008","unstructured":"Guastella AJ, Richardson R, Lovibond PF, Rapee RM, Gaston JE, Mitchell P, Dadds MR (2008) A randomized controlled trial of D-cycloserine enhancement of exposure therapy for social anxiety disorder. Biol Psychiatry 63:544\u2013549","journal-title":"Biol Psychiatry"},{"key":"9727_CR41","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1017\/S1461145712000910","volume":"16","author":"U Heresco-Levy","year":"2013","unstructured":"Heresco-Levy U, Gelfin G, Bloch B, Levin R, Edelman S, Javitt DC, Kremer I (2013) A randomized add-on trial of high-dose D-cycloserine for treatment-resistant depression. Int J Neuropsychopharmacol 16:501\u2013506","journal-title":"Int J Neuropsychopharmacol"},{"key":"9727_CR42","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1001\/archpsyc.63.3.298","volume":"63","author":"SG Hofmann","year":"2006","unstructured":"Hofmann SG, Meuret AE, Smits JA, Simon NM, Pollack MH, Eisenmenger K, Shiekh M, Otto MW (2006) Augmentation of exposure therapy with D-cycloserine for social anxiety disorder. Arch Gen Psychiatry 63:298\u2013304","journal-title":"Arch Gen Psychiatry"},{"key":"9727_CR43","doi-asserted-by":"crossref","unstructured":"Holahan MR and White NM (2002) Conditioned memory modulation, freezing, and avoidance as measures of amygdala-mediated conditioned fear. Neurobiol Learn Mem 77:250\u2013275","DOI":"10.1006\/nlme.2001.4012"},{"key":"9727_CR44","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.tips.2003.09.011","volume":"24","author":"A Holmes","year":"2003","unstructured":"Holmes A, Heilig M, Rupniak NM, Steckler T, Griebel G (2003) Neuropeptide systems as novel therapeutic targets for depression and anxiety disorders. Trends Pharmacol Sci 24:580\u2013588","journal-title":"Trends Pharmacol Sci"},{"key":"9727_CR45","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.annepidem.2005.03.004","volume":"16","author":"HK Kang","year":"2006","unstructured":"Kang HK, Bullman TA, Taylor JW (2006) Risk of selected cardiovascular diseases and posttraumatic stress disorder among former World War II prisoners of war. Ann Epidemiol 16:381\u2013386","journal-title":"Ann Epidemiol"},{"key":"9727_CR46","first-page":"23","volume":"58","author":"D Karlovic","year":"2004","unstructured":"Karlovic D, Martinac M, Buljan D, Zoricic Z (2004) Relationship between serum lipid concentrations and posttraumatic stress disorder symptoms in soldiers with combat experiences. Acta Med Okayama 58:23\u201327","journal-title":"Acta Med Okayama"},{"key":"9727_CR47","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4088\/JCP.09m05347blu","volume":"71","author":"S Kasper","year":"2010","unstructured":"Kasper S, Hajak G, Wulff K, Hoogendijk WJ, Montejo AL, Smeraldi E, Rybakowski JK, Quera-Salva MA, Wirz-Justice AM, Picarel-Blanchot F, Bayle FJ (2010) Efficacy of the novel antidepressant agomelatine on the circadian rest-activity cycle and depressive and anxiety symptoms in patients with major depressive disorder: a randomized, double-blind comparison with sertraline. J Clin Psychiatry 71:109\u2013120","journal-title":"J Clin Psychiatry"},{"issue":"Suppl 5","key":"9727_CR48","first-page":"4","volume":"61","author":"RC Kessler","year":"2000","unstructured":"Kessler RC (2000) Posttraumatic stress disorder: the burden to the individual and to society. J Clin Psychiatry 61(Suppl 5):4\u201312","journal-title":"J Clin Psychiatry"},{"key":"9727_CR49","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1001\/archpsyc.62.6.617","volume":"62","author":"RC Kessler","year":"2005","unstructured":"Kessler RC, Chiu WT, Demler O, Merikangas KR, Walters EE (2005) Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62:617\u2013627","journal-title":"Arch Gen Psychiatry"},{"key":"9727_CR50","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1017\/S1461145709009924","volume":"12","author":"RA Khairova","year":"2009","unstructured":"Khairova RA, Hado-Vieira R, Du J, Manji HK (2009) A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder. Int J Neuropsychopharmacol 12:561\u2013578","journal-title":"Int J Neuropsychopharmacol"},{"key":"9727_CR51","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1126\/science.1585183","volume":"256","author":"JJ Kim","year":"1992","unstructured":"Kim JJ, Fanselow MS (1992) Modality-specific retrograde amnesia of fear. Science 256:675\u2013677","journal-title":"Science"},{"key":"9727_CR52","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.immuni.2009.09.009","volume":"31","author":"D Kioussis","year":"2009","unstructured":"Kioussis D, Pachnis V (2009) Immune and nervous systems: more than just a superficial similarity? Immunity 31:705\u2013710","journal-title":"Immunity"},{"key":"9727_CR53","doi-asserted-by":"crossref","first-page":"10825","DOI":"10.1073\/pnas.152112399","volume":"99","author":"KG Kjelstrup","year":"2002","unstructured":"Kjelstrup KG, Tuvnes FA, Steffenach HA, Murison R, Moser EI, Moser MB (2002) Reduced fear expression after lesions of the ventral hippocampus. Proc Natl Acad Sci U S A 99:10825\u201310830","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9727_CR54","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0361-9230(03)00095-9","volume":"61","author":"B Kornek","year":"2003","unstructured":"Kornek B, Lassmann H (2003) Neuropathology of multiple sclerosis-new concepts. Brain Res Bull 61:321\u2013326","journal-title":"Brain Res Bull"},{"key":"9727_CR55","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/BF02884448","volume":"20","author":"LD Kubzansky","year":"1998","unstructured":"Kubzansky LD, Kawachi I, Weiss ST, Sparrow D (1998) Anxiety and coronary heart disease: a synthesis of epidemiological, psychological, and experimental evidence. Ann Behav Med 20:47\u201358","journal-title":"Ann Behav Med"},{"key":"9727_CR56","doi-asserted-by":"crossref","unstructured":"Kubzansky LD, Koenen K, Jones C, Eaton WW (2009) A prospective study of post-traumatic stress disorder symptoms and coronary heart disease in women. Health Psychol 28(1): 125\u201330","DOI":"10.1037\/0278-6133.28.1.125"},{"key":"9727_CR57","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jneuroim.2010.07.004","volume":"229","author":"M Kuijpers","year":"2010","unstructured":"Kuijpers M, van Gassen KL, de Graan PN, Gruol D (2010) Chronic exposure to the chemokine CCL3 enhances neuronal network activity in rat hippocampal cultures. J Neuroimmunol 229:73\u201380","journal-title":"J Neuroimmunol"},{"key":"9727_CR58","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2174\/156720511794604598","volume":"8","author":"AP Kulkarni","year":"2011","unstructured":"Kulkarni AP, Govender DA, Kotwal GJ, Kellaway LA (2011) Modulation of anxiety behavior by intranasally administered vaccinia virus complement control protein and curcumin in a mouse model of Alzheimer\u2019s disease. Curr Alzheimer Res 8:95\u2013113","journal-title":"Curr Alzheimer Res"},{"key":"9727_CR59","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1001\/archinte.164.17.1873","volume":"164","author":"M Kumari","year":"2004","unstructured":"Kumari M, Head J, Marmot M (2004) Prospective study of social and other risk factors for incidence of type 2 diabetes in the Whitehall II study. Arch Intern Med 164:1873\u20131880","journal-title":"Arch Intern Med"},{"key":"9727_CR60","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.biopsych.2006.12.020","volume":"62","author":"MG Kushner","year":"2007","unstructured":"Kushner MG, Kim SW, Donahue C, Thuras P, Adson D, Kotlyar M, McCabe J, Peterson J, Foa EB (2007) D-cycloserine augmented exposure therapy for obsessive-compulsive disorder. Biol Psychiatry 62:835\u2013838","journal-title":"Biol Psychiatry"},{"key":"9727_CR61","doi-asserted-by":"crossref","unstructured":"Le Grev\u00e8s GM, Le GP, Nyberg F (2005) Age-related effects of IGF-1 on the NMDA-, GH- and IGF-1-receptor mRNA transcripts in the rat hippocampus. Brain Res Bull 65:369\u2013374","DOI":"10.1016\/j.brainresbull.2005.01.012"},{"key":"9727_CR62","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1037\/0735-7044.117.2.341","volume":"117","author":"L Ledgerwood","year":"2003","unstructured":"Ledgerwood L, Richardson R, Cranney J (2003) Effects of D-cycloserine on extinction of conditioned freezing. Behav Neurosci 117:341\u2013349","journal-title":"Behav Neurosci"},{"key":"9727_CR63","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.biopsych.2005.01.023","volume":"57","author":"L Ledgerwood","year":"2005","unstructured":"Ledgerwood L, Richardson R, Cranney J (2005) D-cycloserine facilitates extinction of learned fear: effects on reacquisition and generalized extinction. Biol Psychiatry 57:841\u2013847","journal-title":"Biol Psychiatry"},{"key":"9727_CR64","doi-asserted-by":"crossref","unstructured":"Lewitus GM, Cohen H, Schwartz M (2008) Reducing post-traumatic anxiety by immunization.\u00a0Brain\u00a0Behav Immun 22(7):1108\u20131114","DOI":"10.1016\/j.bbi.2008.05.002"},{"key":"9727_CR65","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.jpsychores.2012.12.011","volume":"74","author":"K Lukaschek","year":"2013","unstructured":"Lukaschek K, Baumert J, Kruse J, Emeny RT, Lacruz ME, Huth C, Thorand B, Holle R, Rathmann W, Meisinger C, Ladwig KH (2013) Relationship between posttraumatic stress disorder and type 2 diabetes in a population-based cross-sectional study with 2970 participants. J Psychosom Res 74:340\u2013345","journal-title":"J Psychosom Res"},{"key":"9727_CR66","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jad.2007.08.013","volume":"107","author":"DB Maia","year":"2008","unstructured":"Maia DB, Marmar CR, Mendlowicz MV, Metzler T, Nobrega A, Peres MC, Coutinho ES, Volchan E, Figueira I (2008) Abnormal serum lipid profile in Brazilian police officers with post-traumatic stress disorder. J Affect Disord 107:259\u2013263","journal-title":"J Affect Disord"},{"key":"9727_CR67","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0091-3057(01)00691-8","volume":"71","author":"P Malmberg-Aiello","year":"2002","unstructured":"Malmberg-Aiello P, Ipponi A, Bartolini A, Schunack W (2002) Mouse light\/dark box test reveals anxiogenic-like effects by activation of histamine H1 receptors. Pharmacol Biochem Behav 71:313\u2013318","journal-title":"Pharmacol Biochem Behav"},{"key":"9727_CR68","doi-asserted-by":"crossref","first-page":"8892","DOI":"10.1523\/JNEUROSCI.0365-06.2006","volume":"26","author":"SC Mao","year":"2006","unstructured":"Mao SC, Hsiao YH, Gean PW (2006) Extinction training in conjunction with a partial agonist of the glycine site on the NMDA receptor erases memory trace. J Neurosci 26:8892\u20138899","journal-title":"J Neurosci"},{"key":"9727_CR69","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1038\/npp.2008.30","volume":"33","author":"SC Mao","year":"2008","unstructured":"Mao SC, Lin HC, Gean PW (2008) Augmentation of fear extinction by D-cycloserine is blocked by proteasome inhibitors. Neuropsychopharmacology 33:3085\u20133095","journal-title":"Neuropsychopharmacology"},{"key":"9727_CR70","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0166-4328(99)00188-6","volume":"110","author":"S Maren","year":"2000","unstructured":"Maren S, Holt W (2000) The hippocampus and contextual memory retrieval in Pavlovian conditioning. Behav Brain Res 110:97\u2013108","journal-title":"Behav Brain Res"},{"key":"9727_CR71","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.neubiorev.2008.10.005","volume":"33","author":"J McAfoose","year":"2009","unstructured":"McAfoose J, Baune BT (2009) Evidence for a cytokine model of cognitive function. Neurosci Biobehav Rev 33:355\u2013366","journal-title":"Neurosci Biobehav Rev"},{"issue":"Suppl 1","key":"9727_CR72","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.parkreldis.2004.01.005","volume":"10","author":"PL McGeer","year":"2004","unstructured":"McGeer PL, McGeer EG (2004) Inflammation and neurodegeneration in Parkinson\u2019s disease. Parkinsonism Relat Disord 10(Suppl 1):S3\u2013S7","journal-title":"Parkinsonism Relat Disord"},{"key":"9727_CR73","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1037\/0735-7044.118.1.63","volume":"118","author":"SB McHugh","year":"2004","unstructured":"McHugh SB, Deacon RM, Rawlins JN, Bannerman DM (2004) Amygdala and ventral hippocampus contribute differentially to mechanisms of fear and anxiety. Behav Neurosci 118:63\u201378","journal-title":"Behav Neurosci"},{"key":"9727_CR74","doi-asserted-by":"crossref","unstructured":"Miller AH, Maletic V, Raison CL (2009) Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry 65:732\u2013741","DOI":"10.1016\/j.biopsych.2008.11.029"},{"key":"9727_CR75","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1111\/j.1471-4159.2010.06849.x","volume":"114","author":"E Molina-Holgado","year":"2010","unstructured":"Molina-Holgado E, Molina-Holgado F (2010) Mending the broken brain: neuroimmune interactions in neurogenesis. J Neurochem 114:1277\u20131290","journal-title":"J Neurochem"},{"key":"9727_CR76","author":"R Monteiro","year":"2010","unstructured":"Monteiro R, Azevedo I (2010) Chronic inflammation in obesity and the metabolic syndrome. Mediat Inflamm. doi: 10.1155\/2010\/289645","journal-title":"Mediat Inflamm"},{"key":"9727_CR77","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2337\/diacare.23.2.197","volume":"23","author":"JM Mooy","year":"2000","unstructured":"Mooy JM, de Vries H, Grootenhuis PA, Bouter LM, Heine RJ (2000) Major stressful life events in relation to prevalence of undetected type 2 diabetes: the Hoorn Study. Diabetes Care 23:197\u2013201","journal-title":"Diabetes Care"},{"key":"9727_CR78","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1159\/000241443","volume":"39","author":"B Morris","year":"1981","unstructured":"Morris B, Morris R, Kenyon CJ (1981) Effect of adrenalectomy on the transmission of IgG in young rats. Biol Neonate 39:239\u2013245","journal-title":"Biol Neonate"},{"key":"9727_CR79","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/297681a0","volume":"297","author":"RG Morris","year":"1982","unstructured":"Morris RG, Garrud P, Rawlins JN, O\u2019Keefe J (1982) Place navigation impaired in rats with hippocampal lesions. Nature 297:681\u2013683","journal-title":"Nature"},{"key":"9727_CR80","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/npp.2010.88","volume":"36","author":"KM Myers","year":"2011","unstructured":"Myers KM, Carlezon WA Jr, Davis M (2011) Glutamate receptors in extinction and extinction-based therapies for psychiatric illness. Neuropsychopharmacology 36:274\u2013293","journal-title":"Neuropsychopharmacology"},{"key":"9727_CR81","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.bbi.2010.12.001","volume":"25","author":"TC Neylan","year":"2011","unstructured":"Neylan TC, Sun B, Rempel H, Ross J, Lenoci M, O\u2019Donovan A, Pulliam L (2011) Suppressed monocyte gene expression profile in men versus women with PTSD. Brain Behav Immun 25:524\u2013531","journal-title":"Brain Behav Immun"},{"key":"9727_CR82","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/0006-8993(93)90468-3","volume":"613","author":"MS Oitzl","year":"1993","unstructured":"Oitzl MS, van Oers H, Schobitz B, de Kloet ER (1993) Interleukin-1 beta, but not interleukin-6, impairs spatial navigation learning. Brain Res 613:160\u2013163","journal-title":"Brain Res"},{"key":"9727_CR83","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.biopsych.2009.07.036","volume":"67","author":"MW Otto","year":"2010","unstructured":"Otto MW, Tolin DF, Simon NM, Pearlson GD, Basden S, Meunier SA, Hofmann SG, Eisenmenger K, Krystal JH, Pollack MH (2010) Efficacy of d-cycloserine for enhancing response to cognitive-behavior therapy for panic disorder. Biol Psychiatry 67:365\u2013370","journal-title":"Biol Psychiatry"},{"key":"9727_CR84","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.biopsych.2006.03.042","volume":"60","author":"MP Paulus","year":"2006","unstructured":"Paulus MP, Stein MB (2006) An insular view of anxiety. Biol Psychiatry 60:383\u2013387","journal-title":"Biol Psychiatry"},{"key":"9727_CR85","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00213-013-3020-1","volume":"228","author":"J Philbert","year":"2013","unstructured":"Philbert J, Belzung C, Griebel G (2013) The CRF(1) receptor antagonist SSR125543 prevents stress-induced cognitive deficit associated with hippocampal dysfunction: comparison with paroxetine and D-cycloserine. Psychopharmacology (Berl) 228:97\u2013107","journal-title":"Psychopharmacology (Berl)"},{"key":"9727_CR86","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1532-5415.2011.03788.x","volume":"60","author":"RH Pietrzak","year":"2012","unstructured":"Pietrzak RH, Goldstein RB, Southwick SM, Grant BF (2012) Physical health conditions associated with posttraumatic stress disorder in U.S. older adults: results from wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions. J Am Geriatr Soc 60:296\u2013303","journal-title":"J Am Geriatr Soc"},{"key":"9727_CR87","first-page":"457","volume":"5","author":"M Pitk\u00e4nen","year":"1995","unstructured":"Pitk\u00e4nen M, Sirvi J, MacDonald E, Niemi S, Ekonsalo T, Riekkinen P (1995) The effects of D-cycloserine and MK-801 on the performance of rats in two spatial learning and memory tasks. Eur Neuropsychopharmacol 5:457\u2013463","journal-title":"Eur Neuropsychopharmacol"},{"key":"9727_CR88","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S0893-133X(02)00371-8","volume":"27","author":"D Polese","year":"2002","unstructured":"Polese D, de Serpis AA, Ambesi-Impiombato A, Muscettola G, de Bartolomeis A (2002) Homer 1a gene expression modulation by antipsychotic drugs: involvement of the glutamate metabotropic system and effects of D-cycloserine. Neuropsychopharmacology 27:906\u2013913","journal-title":"Neuropsychopharmacology"},{"key":"9727_CR89","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/sj.npp.1301555","volume":"33","author":"GJ Quirk","year":"2008","unstructured":"Quirk GJ, Mueller D (2008) Neural mechanisms of extinction learning and retrieval. Neuropsychopharmacology 33:56\u201372","journal-title":"Neuropsychopharmacology"},{"key":"9727_CR90","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s11126-009-9096-4","volume":"80","author":"SU Qureshi","year":"2009","unstructured":"Qureshi SU, Pyne JM, Magruder KM, Schulz PE, Kunik ME (2009) The link between post-traumatic stress disorder and physical comorbidities: a systematic review. Psychiatry Q 80:87\u201397","journal-title":"Psychiatry Q"},{"key":"9727_CR91","doi-asserted-by":"crossref","unstructured":"Raikkonen K, Matthews KA, Kuller LH (2002) The relationship between psychological risk attributes and the metabolic syndrome in healthy women: antecedent or consequence?\u00a0Metabolism 51:1573\u20131577","DOI":"10.1053\/meta.2002.36301"},{"key":"9727_CR92","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.immuni.2009.09.010","volume":"31","author":"RM Ransohoff","year":"2009","unstructured":"Ransohoff RM (2009) Chemokines and chemokine receptors: standing at the crossroads of immunobiology and neurobiology. Immunity 31:711\u2013721","journal-title":"Immunity"},{"key":"9727_CR93","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1001\/archpsyc.61.11.1136","volume":"61","author":"KJ Ressler","year":"2004","unstructured":"Ressler KJ, Rothbaum BO, Tannenbaum L, Anderson P, Graap K, Zimand E, Hodges L, Davis M (2004) Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear. Arch Gen Psychiatry 61:1136\u20131144","journal-title":"Arch Gen Psychiatry"},{"key":"9727_CR94","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1023\/B:JOTS.0000004077.22408.cf","volume":"16","author":"PP Schnurr","year":"2003","unstructured":"Schnurr PP, Lunney CA, Sengupta A, Waelde LC (2003) A descriptive analysis of PTSD chronicity in Vietnam veterans. J Trauma Stress 16:545\u2013553","journal-title":"J Trauma Stress"},{"key":"9727_CR95","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/mp.2010.31","volume":"15","author":"M Schwartz","year":"2010","unstructured":"Schwartz M, Shechter R (2010) Protective autoimmunity functions by intracranial immunosurveillance to support the mind: The missing link between health and disease. Mol Psychiatry 15:342\u2013354","journal-title":"Mol Psychiatry"},{"key":"9727_CR96","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/S0022-510X(98)00086-0","volume":"157","author":"F Sellebjerg","year":"1998","unstructured":"Sellebjerg F, Jaliashvili I, Christiansen M, Garred P (1998) Intrathecal activation of the complement system and disability in multiple sclerosis. J Neurol Sci 157:168\u2013174","journal-title":"J Neurol Sci"},{"key":"9727_CR97","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0166-4328(96)00170-2","volume":"72","author":"HS Sharma","year":"1995","unstructured":"Sharma HS, Westman J, Navarro JC, Dey PK, Nyberg F (1995) Probable involvement of serotonin in the increased permeability of the blood-brain barrier by forced swimming. An experimental study using Evans blue and 131I-sodium tracers in the rat. Behav Brain Res 72:189\u2013196","journal-title":"Behav Brain Res"},{"key":"9727_CR98","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.jpsychires.2006.07.017","volume":"41","author":"A Siegmund","year":"2007","unstructured":"Siegmund A, Wotjak CT (2007) A mouse model of posttraumatic stress disorder that distinguishes between conditioned and sensitised fear. J Psychiatr Res 41:848\u2013860","journal-title":"J Psychiatr Res"},{"key":"9727_CR99","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0361-9230(97)00335-3","volume":"45","author":"I Skultetyova","year":"1998","unstructured":"Skultetyova I, Tokarev D, Jezova D (1998) Stress-induced increase in blood-brain barrier permeability in control and monosodium glutamate-treated rats. Brain Res Bull 45:175\u2013178","journal-title":"Brain Res Bull"},{"key":"9727_CR100","author":"JA Smits","year":"2013","unstructured":"Smits JA, Rosenfield D, Otto MW, Marques L, Davis ML, Meuret AE, Simon NM, Pollack MH, Hofmann SG (2013) D-cycloserine enhancement of exposure therapy for social anxiety disorder depends on the success of exposure sessions. J Psychiatr Res. doi: 10.1016\/j.jpsychires.2013.06.020","journal-title":"J Psychiatr Res"},{"key":"9727_CR101","first-page":"685","volume":"43","author":"V Solter","year":"2002","unstructured":"Solter V, Thaller V, Karlovic D, Crnkovic D (2002) Elevated serum lipids in veterans with combat-related chronic posttraumatic stress disorder. Croat Med J 43:685\u2013689","journal-title":"Croat Med J"},{"key":"9727_CR102","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jneuroim.2009.01.010","volume":"208","author":"S Spulber","year":"2009","unstructured":"Spulber S, Mateos L, Oprica M, Cedazo-Minguez A, Bartfai T, Winblad B, Schultzberg M (2009) Impaired long term memory consolidation in transgenic mice overexpressing the human soluble form of IL-1ra in the brain. J Neuroimmunol 208:46\u201353","journal-title":"J Neuroimmunol"},{"key":"9727_CR103","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.bbi.2007.03.011","volume":"21","author":"A Steptoe","year":"2007","unstructured":"Steptoe A, Hamer M, Chida Y (2007) The effects of acute psychological stress on circulating inflammatory factors in humans: a review and meta-analysis. Brain Behav Immun 21:901\u2013912","journal-title":"Brain Behav Immun"},{"key":"9727_CR104","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.biopsych.2010.07.015","volume":"68","author":"EA Storch","year":"2010","unstructured":"Storch EA, Murphy TK, Goodman WK, Geffken GR, Lewin AB, Henin A, Micco JA, Sprich S, Wilhelm S, Bengtson M, Geller DA (2010) A preliminary study of D-cycloserine augmentation of cognitive-behavioral therapy in pediatric obsessive-compulsive disorder. Biol Psychiatry 68:1073\u20131076","journal-title":"Biol Psychiatry"},{"key":"9727_CR105","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00005-010-0089-7","volume":"58","author":"Y Su","year":"2010","unstructured":"Su Y, Zhang K, Schluesener HJ (2010) Antimicrobial peptides in the brain. Arch Immunol Ther Exp (Warsz) 58:365\u2013377","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"9727_CR106","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/hipo.10043","volume":"13","author":"G Szapiro","year":"2003","unstructured":"Szapiro G, Vianna MR, McGaugh JL, Medina JH, Izquierdo I (2003) The role of NMDA glutamate receptors, PKA, MAPK, and CAMKII in the hippocampus in extinction of conditioned fear. Hippocampus 13:53\u201358","journal-title":"Hippocampus"},{"key":"9727_CR107","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1189\/jlb.0608385","volume":"85","author":"BR Tambuyzer","year":"2009","unstructured":"Tambuyzer BR, Ponsaerts P, Nouwen EJ (2009) Microglia: gatekeepers of central nervous system immunology. J Leukoc Biol 85:352\u2013370","journal-title":"J Leukoc Biol"},{"key":"9727_CR108","doi-asserted-by":"crossref","unstructured":"Thompson KL, Pine PS, Rosenzweig BA, Turpaz Y, Retief J (2007) Characterization of the effect of sample quality on high density oligonucleotide microarray data using progressively degraded rat liver RNA. BMC Biotechnol 7:57","DOI":"10.1186\/1472-6750-7-57"},{"key":"9727_CR109","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/bioinformatics\/btp120","volume":"25","author":"C Trapnell","year":"2009","unstructured":"Trapnell C, Pachter L, Salzberg SL (2009) TopHat: discovering splice junctions with RNA-Seq. Bioinformatics 25:1105\u20131111","journal-title":"Bioinformatics"},{"key":"9727_CR110","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nprot.2012.016","volume":"7","author":"C Trapnell","year":"2012","unstructured":"Trapnell C, Roberts A, Goff L, Pertea G, Kim D, Kelley DR, Pimentel H, Salzberg SL, Rinn JL, Pachter L (2012) Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks. Nat Protoc 7:562\u2013578","journal-title":"Nat Protoc"},{"key":"9727_CR111","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1176\/ajp.156.3.467","volume":"156","author":"GE Tsai","year":"1999","unstructured":"Tsai GE, Falk WE, Gunther J, Coyle JT (1999) Improved cognition in Alzheimer\u2019s disease with short-term D-cycloserine treatment. Am J Psychiatry 156:467\u2013469","journal-title":"Am J Psychiatry"},{"key":"9727_CR112","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.biocel.2004.07.009","volume":"37","author":"EE Tuppo","year":"2005","unstructured":"Tuppo EE, Arias HR (2005) The role of inflammation in Alzheimer\u2019s disease. Int J Biochem Cell Biol 37:289\u2013305","journal-title":"Int J Biochem Cell Biol"},{"key":"9727_CR113","author":"JH Turner","year":"2013","unstructured":"Turner JH, Neylan TC, Schiller NB, Li Y, Cohen BE (2013) Objective evidence of myocardial ischemia in patients with posttraumatic stress disorder. Biol Psychiatry. doi: 10.1016\/j.biopsych.2013.07.012","journal-title":"Biol Psychiatry"},{"key":"9727_CR114","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1600-0447.2010.01565.x","volume":"122","author":"AK Reedt Dortland van","year":"2010","unstructured":"van Reedt Dortland AK, Giltay EJ, van Veen T, Zitman FG, Penninx BW (2010) Metabolic syndrome abnormalities are associated with severity of anxiety and depression and with tricyclic antidepressant use. Acta Psychiatr Scand 122:30\u201339","journal-title":"Acta Psychiatr Scand"},{"key":"9727_CR115","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.neuint.2010.02.002","volume":"57","author":"A Verkhratsky","year":"2010","unstructured":"Verkhratsky A (2010) Physiology of neuronal-glial networking. Neurochem Int 57:332\u2013343","journal-title":"Neurochem Int"},{"key":"9727_CR116","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1523\/JNEUROSCI.22-06-02343.2002","volume":"22","author":"DL Walker","year":"2002","unstructured":"Walker DL, Ressler KJ, Lu KT, Davis M (2002) Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats. J Neurosci 22:2343\u20132351","journal-title":"J Neurosci"},{"key":"9727_CR117","doi-asserted-by":"crossref","first-page":"513","DOI":"10.5694\/j.1326-5377.1993.tb138003.x","volume":"159","author":"IP Watson","year":"1993","unstructured":"Watson IP, Muller HK, Jones IH, Bradley AJ (1993) Cell-mediated immunity in combat veterans with post-traumatic stress disorder. Med J Aust 159:513\u2013516","journal-title":"Med J Aust"},{"key":"9727_CR118","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jpsychires.2008.03.011","volume":"43","author":"NS Werner","year":"2009","unstructured":"Werner NS, Meindl T, Engel RR, Rosner R, Riedel M, Reiser M, Fast K (2009) Hippocampal function during associative learning in patients with posttraumatic stress disorder. J Psychiatr Res 43:309\u2013318","journal-title":"J Psychiatr Res"},{"key":"9727_CR119","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1176\/appi.ajp.2007.07050776","volume":"165","author":"S Wilhelm","year":"2008","unstructured":"Wilhelm S, Buhlmann U, Tolin DF, Meunier SA, Pearlson GD, Reese HE, Cannistraro P, Jenike MA, Rauch SL (2008) Augmentation of behavior therapy with D-cycloserine for obsessive-compulsive disorder. Am J Psychiatry 165:335\u2013341","journal-title":"Am J Psychiatry"},{"key":"9727_CR120","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1073\/pnas.97.1.325","volume":"97","author":"ML Wong","year":"2000","unstructured":"Wong ML, Kling MA, Munson PJ, Listwak S, Licinio J, Prolo P, Karp B et al (2000) Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: relation to hypercortisolism and corticotropin-releasing hormone. Proc Natl Acad Sci U S A 97:325\u2013330","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9727_CR121","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/BF00427222","volume":"84","author":"T Yamada","year":"1992","unstructured":"Yamada T, McGeer PL, McGeer EG (1992) Lewy bodies in Parkinson\u2019s disease are recognized by antibodies to complement proteins. Acta Neuropathol 84:100\u2013104","journal-title":"Acta Neuropathol"},{"key":"9727_CR122","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1038\/sj.npp.1301605","volume":"33","author":"S Yamamoto","year":"2008","unstructured":"Yamamoto S, Morinobu S, Fuchikami M, Kurata A, Kozuru T, Yamawaki S (2008) Effects of single prolonged stress and D-cycloserine on contextual fear extinction and hippocampal NMDA receptor expression in a rat model of PTSD. Neuropsychopharmacology 33:2108\u20132116","journal-title":"Neuropsychopharmacology"},{"key":"9727_CR123","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.neuroscience.2005.04.003","volume":"134","author":"YL Yang","year":"2005","unstructured":"Yang YL, Lu KT (2005) Facilitation of conditioned fear extinction by d-cycloserine is mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase cascades and requires de novo protein synthesis in basolateral nucleus of amygdala. Neuroscience 134:247\u2013260","journal-title":"Neuroscience"},{"key":"9727_CR124","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.biopsych.2009.02.034","volume":"66","author":"R Yehuda","year":"2009","unstructured":"Yehuda R, Cai G, Golier JA, Sarapas C, Galea S, Ising M, Rein T, Schmeidler J, Muller-Myhsok B, Holsboer F, Buxbaum JD (2009) Gene expression patterns associated with posttraumatic stress disorder following exposure to the World Trade Center attacks. Biol Psychiatry 66:708\u2013711","journal-title":"Biol Psychiatry"},{"key":"9727_CR125","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.bbi.2010.10.015","volume":"25","author":"R Yirmiya","year":"2011","unstructured":"Yirmiya R, Goshen I (2011) Immune modulation of learning, memory, neural plasticity and neurogenesis. Brain Behav Immun 25:181\u2013213","journal-title":"Brain Behav Immun"},{"key":"9727_CR126","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1037\/0735-7044.108.1.19","volume":"108","author":"SL Young","year":"1994","unstructured":"Young SL, Bohenek DL, Fanselow MS (1994) NMDA processes mediate anterograde amnesia of contextual fear conditioning induced by hippocampal damage: immunization against amnesia by context preexposure. Behav Neurosci 108:19\u201329","journal-title":"Behav Neurosci"},{"key":"9727_CR127","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sj.mp.4001905","volume":"12","author":"J Zieker","year":"2007","unstructured":"Zieker J, Zieker D, Jatzko A, Dietzsch J, Nieselt K, Schmitt A, Bertsch T, Fassbender K, Spanagel R, Northoff H, Gebicke-Haerter PJ (2007) Differential gene expression in peripheral blood of patients suffering from post-traumatic stress disorder. Mol Psychiatry 12:1","journal-title":"Mol Psychiatry"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-015-9727-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11011-015-9727-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-015-9727-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T09:12:23Z","timestamp":1718097143000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11011-015-9727-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,23]]},"references-count":127,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["9727"],"URL":"https:\/\/doi.org\/10.1007\/s11011-015-9727-4","relation":{},"ISSN":["0885-7490","1573-7365"],"issn-type":[{"value":"0885-7490","type":"print"},{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,23]]}}}