{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:57:21Z","timestamp":1792015041423,"version":"4.4.0"},"reference-count":115,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T00:00:00Z","timestamp":1459728000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1007\/s11011-016-9822-1","type":"journal-article","created":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T01:28:02Z","timestamp":1459733282000},"page":"749-759","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["The known and missing links between Toxoplasma gondii and schizophrenia"],"prefix":"10.1007","volume":"31","author":[{"given":"Hany M.","family":"Elsheikha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietrich","family":"B\u00fcsselberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Quan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,4,4]]},"reference":[{"issue":"1\u20132","key":"9822_CR1","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.brainresrev.2010.09.008","volume":"66","author":"M Bentivoglio","year":"2011","unstructured":"Bentivoglio M, Mariotti R, Bertini G (2011) Neuroinflammation and brain infections: historical context and current perspectives. Brain Res Rev 66(1\u20132):152\u2013173","journal-title":"Brain Res Rev"},{"key":"9822_CR2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0028925","volume":"6","author":"M Berenreiterov\u00e1","year":"2011","unstructured":"Berenreiterov\u00e1 M, Flegr J, Kub\u011bna AA, N\u011bmec P (2011) The distribution of Toxoplasma gondii cysts in the brain of a mouse with latent toxoplasmosis: implications for the behavioral manipulation hypothesis. PLoS One 6, e28925","journal-title":"PLoS One"},{"key":"9822_CR3","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1600-0447.2007.01058.x","volume":"434","author":"M Berk","year":"2007","unstructured":"Berk M, Dodd S, Kauer-Sant\u2019anna M, Malhi GS, Bourin M, Kapczinski F, Norman T (2007) Dopamine dysregulation syndrome: implications for a dopamine hypothesis of bipolar disorder. Acta Psychiatr Scand Suppl 434:41\u201349","journal-title":"Acta Psychiatr Scand Suppl"},{"key":"9822_CR4","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/j.neuropharm.2011.08.010","volume":"62","author":"S Berretta","year":"2012","unstructured":"Berretta S (2012) Extracellular matrix abnormalities in schizophrenia. Neuropharmacology 62:1584\u20131597","journal-title":"Neuropharmacology"},{"key":"9822_CR5","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/schbul\/sbt006","volume":"39","author":"R Bhadra","year":"2013","unstructured":"Bhadra R, Cobb DA, Weiss LM, Khan IA (2013) Psychiatric disorders in toxoplasma seropositive patients-The CD8 connection. Schizophr Bull 39:485\u2013489","journal-title":"Schizophr Bull"},{"key":"9822_CR6","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/pim.12173","volume":"37","author":"N Blanchard","year":"2015","unstructured":"Blanchard N, Dunay IR, Schluter D (2015) Persistence of Toxoplasma gondii in the central nervous system: a fine-tuned balance between the parasite, the brain and the immune system. Parasite Immunol 37:150\u2013158","journal-title":"Parasite Immunol"},{"issue":"3","key":"9822_CR7","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/j.neuropharm.2010.12.027","volume":"62","author":"NJ Bradshaw","year":"2012","unstructured":"Bradshaw NJ, Porteous DJ (2012) DISC1-binding proteins in neural development, signalling and schizophrenia. Neuropharmacology 62(3):1230\u20131241","journal-title":"Neuropharmacology"},{"key":"9822_CR8","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.neuron.2008.06.028","volume":"59","author":"BG Brinkmann","year":"2008","unstructured":"Brinkmann BG, Agarwal A, Sereda MW, Garratt AN, M\u00fcller T, Wende H, Stassart RM, Nawaz S, Humml C, Velanac V, Radyushkin K, Goebbels S, Fischer TM, Franklin RJ, Lai C, Ehrenreich H, Birchmeier C, Schwab MH, Nave KA (2008) Neuregulin-1\/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system. Neuron 59:581\u2013595","journal-title":"Neuron"},{"key":"9822_CR9","first-page":"47","volume":"5","author":"R Brisch","year":"2014","unstructured":"Brisch R, Saniotis A, Wolf R, Bielau H, Bernstein HG, Steiner J, Bogerts B, Braun K, Jankowski Z, Kumaratilake J, Henneberg M, Gos T (2014) The role of dopamine in schizophrenia from a neurobiological and evolutionary perspective: old fashioned, but still in vogue. Front Psychiatr 5:47","journal-title":"Front Psychiatr"},{"issue":"6","key":"9822_CR10","doi-asserted-by":"crossref","first-page":"e01428","DOI":"10.1128\/mBio.01428-15","volume":"6","author":"JM Brooks","year":"2015","unstructured":"Brooks JM, Carrillo GL, Su J, Lindsay DS, Fox MA, Blader IJ (2015) Toxoplasma gondii infections alter GABAergic synapses and signaling in the central nervous system. MBio 6(6):e01428\u201315","journal-title":"MBio"},{"key":"9822_CR11","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1176\/appi.ajp.2009.09030361","volume":"167","author":"AS Brown","year":"2010","unstructured":"Brown AS, Derkits EJ (2010) Prenatal infection and schizophrenia: a review of epidemiologic and translational studies. Am J Psychiatry 167:261\u2013280","journal-title":"Am J Psychiatry"},{"key":"9822_CR12","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/9780470751251.ch13","volume":"289","author":"A Buonanno","year":"2008","unstructured":"Buonanno A, Kwon OB, Yan L, Gonzalez C, Longart M, Hoffman D, Vullhorst D (2008) Neuregulins and neuronal plasticity: possible relevance in schizophrenia. Novartis Found Symp 289:165\u2013177","journal-title":"Novartis Found Symp"},{"key":"9822_CR13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.schres.2006.05.023","volume":"86","author":"CJ Carter","year":"2006","unstructured":"Carter CJ (2006) Schizophrenia susceptibility genes converge on interlinked pathways related to glutamatergic transmission and long-term potentiation, oxidative stress and oligodendrocyte viability. Schizophr Res 86:1\u201314","journal-title":"Schizophr Res"},{"key":"9822_CR14","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1093\/schbul\/sbm007","volume":"33","author":"CJ Carter","year":"2007","unstructured":"Carter CJ (2007) eIF2B and oligodendrocyte survival: where nature and nurture meet in bipolar disorder and schizophrenia? Schizophr Bull 33:1343\u20131353","journal-title":"Schizophr Bull"},{"issue":"6","key":"9822_CR15","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1093\/schbul\/sbn054","volume":"35","author":"CJ Carter","year":"2009","unstructured":"Carter CJ (2009) Schizophrenia susceptibility genes directly implicated in the life cycles of pathogens: cytomegalovirus, influenza, herpes simplex, rubella, and Toxoplasma gondii. Schizophr Bull 35(6):1163\u20131182","journal-title":"Schizophr Bull"},{"key":"9822_CR16","doi-asserted-by":"crossref","DOI":"10.1042\/AN20100027","volume":"3","author":"RT Clark","year":"2011","unstructured":"Clark RT, Nance JP, Noor S, Wilson EH (2011) T-cell production of matrix metalloproteinases and inhibition of parasite clearance by TIMP-1 during chronic Toxoplasma infection in the brain. ASN Neuro 3, e00049","journal-title":"ASN Neuro"},{"key":"9822_CR17","doi-asserted-by":"crossref","unstructured":"da Silva RC, Langoni H (2009) Toxoplasma gondii: host-parasite interaction and behavior manipulation. Parasitol Res 105(4):893\u2013898","DOI":"10.1007\/s00436-009-1526-6"},{"key":"9822_CR18","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.schres.2007.03.022","volume":"93","author":"F Dickerson","year":"2007","unstructured":"Dickerson F, Stallings C, Origoni A, Boronow J, Yolken R (2007) C-reactive protein is associated with the severity of cognitive impairment but not of psychiatric symptoms in individuals with schizophrenia. Schizophr Res 93:261\u2013265","journal-title":"Schizophr Res"},{"key":"9822_CR19","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.schres.2012.10.041","volume":"143","author":"F Dickerson","year":"2013","unstructured":"Dickerson F, Stallings C, Origoni A, Vaughan C, Khushalani S, Yang S, Yolken R (2013) C-reactive protein is elevated in schizophrenia. Schizophr Res 143:198\u2013202","journal-title":"Schizophr Res"},{"issue":"3","key":"9822_CR20","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jinf.2005.10.029","volume":"53","author":"S Eren","year":"2006","unstructured":"Eren S, Bayam G, Erg\u00f6n\u00fcl O, Celikba\u015f A, Pazvanto\u011flu O, Baykam N, Dokuzo\u011fuz B, Dilbaz N (2006) Cognitive and emotional changes in neurobrucellosis. J Infect 53(3):184\u2013189","journal-title":"J Infect"},{"key":"9822_CR21","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.bbi.2013.11.012","volume":"37","author":"AK Evans","year":"2014","unstructured":"Evans AK, Strassmann PS, Lee IP, Sapolsky RM (2014) Patterns of Toxoplasma gondii cyst distribution in the forebrain associate with individual variation in predator odor avoidance and anxiety-related behavior in male Long-Evans rats. Brain Behav Immun 37:122\u2013133","journal-title":"Brain Behav Immun"},{"key":"9822_CR22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jns.2015.02.028","volume":"351","author":"S Fabiani","year":"2015","unstructured":"Fabiani S, Pinto B, Bonuccelli U, Bruschi F (2015) Neurobiological studies on the relationship between toxoplasmosis and neuropsychiatric diseases. J Neurol Sci 351:3\u20138","journal-title":"J Neurol Sci"},{"issue":"2","key":"9822_CR23","doi-asserted-by":"crossref","first-page":"105","DOI":"10.14411\/fp.2010.013","volume":"57","author":"A Fekadu","year":"2010","unstructured":"Fekadu A, Shibre T, Cleare AJ (2010) Toxoplasmosis as a cause for behaviour disorders\u2014overview of evidence and mechanisms. Folia Parasitol (Praha) 57(2):105\u2013113","journal-title":"Folia Parasitol (Praha)"},{"issue":"3","key":"9822_CR24","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/schbul\/sbl074","volume":"33","author":"J Flegr","year":"2007","unstructured":"Flegr J (2007) Effects of Toxoplasma on human behavior. Schizophr Bull 33(3):757\u2013760","journal-title":"Schizophr Bull"},{"key":"9822_CR25","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1242\/jeb.073635","volume":"216","author":"J Flegr","year":"2013","unstructured":"Flegr J (2013) Influence of latent Toxoplasma infection on human personality, physiology and morphology: pros and cons of the Toxoplasma\u2013human model in studying the manipulation hypothesis. J Exp Biol 216:127\u2013133","journal-title":"J Exp Biol"},{"issue":"3","key":"9822_CR26","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0301-0511(03)00075-9","volume":"63","author":"J Flegr","year":"2003","unstructured":"Flegr J, Preiss M, Klose J, Havl\u00edcek J, Vit\u00e1kov\u00e1 M, Kodym P (2003) Decreased level of psychobiological factor novelty seeking and lower intelligence in men latently infected with the protozoan parasite Toxoplasma gondii Dopamine, a missing link between schizophrenia and toxoplasmosis? Biol Psychol 63(3):253\u2013268","journal-title":"Biol Psychol"},{"key":"9822_CR27","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1017\/S0031182007004064","volume":"135","author":"J Flegr","year":"2008","unstructured":"Flegr J, Lindova J, Kodym P (2008) Sex-dependent toxoplasmosis-associated differences in testosterone concentration in humans. Parasitology 135:427\u2013431","journal-title":"Parasitology"},{"key":"9822_CR28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001389","volume":"5","author":"J Flegr","year":"2011","unstructured":"Flegr J, Lenochova P, Hodny Z, Vondrova M (2011) Fatal attraction phenomenon in humans: cat odour attractiveness increased for Toxoplasma-infected men while decreased for infected women. PLoS Negl Trop Dis 5, e1389","journal-title":"PLoS Negl Trop Dis"},{"key":"9822_CR29","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/sj.mp.4001337","volume":"8","author":"SW Flynn","year":"2003","unstructured":"Flynn SW, Lang DJ, Mackay AL, Goghari V, Vavasour IM, Whittall KP, Smith GN, Arango V, Mann JJ, Dwork AJ, Falkai P, Honer WG (2003) Abnormalities of myelination in schizophrenia detected in vivo with MRI, and post-mortem with analysis of oligodendrocyte proteins. Mol Psychiatry 8:811\u2013820","journal-title":"Mol Psychiatry"},{"issue":"12","key":"9822_CR30","volume":"8","author":"JM Fuks","year":"2012","unstructured":"Fuks JM, Arrighi RBG, Weidner JM, Kumar Mendu S, Jin Z, Wallin RP, Rethi B, Birnir B, Barragan A (2012) GABAergic signaling is linked to a hypermigratory phenotype in dendritic cells infected by Toxoplasma gondii. PLoS Pathog 8(12), e1003051","journal-title":"PLoS Pathog"},{"key":"9822_CR31","doi-asserted-by":"crossref","unstructured":"Gao HM, Zhou H, Hong JS (2014) Oxidative stress, neuroinflammation, and neurodegeneration. In Neuroinflammation and Neurodegeneration, Springer: 81\u2013104","DOI":"10.1007\/978-1-4939-1071-7_5"},{"key":"9822_CR32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0004801","volume":"4","author":"EA Gaskell","year":"2009","unstructured":"Gaskell EA, Smith JE, Pinney JW, Westhead DR, McConkey GA (2009) A unique dual activity amino acid hydroxylase in Toxoplasma gondii. PLoS One 4, e4801","journal-title":"PLoS One"},{"issue":"1","key":"9822_CR33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exppara.2012.10.005","volume":"133","author":"J Gatkowska","year":"2013","unstructured":"Gatkowska J, Wieczorek M, Dziadek B, Dzitko K, Dlugonska H (2013) Sex-dependent neurotransmitter level changes in brains of Toxoplasma gondii infected mice. Exp Parasitol 133(1):1\u20137","journal-title":"Exp Parasitol"},{"key":"9822_CR34","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/jcp.22783","volume":"227","author":"AK Ghosh","year":"2012","unstructured":"Ghosh AK, Vaughan DE (2012) PAI-1 in tissue fibrosis. J Cell Physiol 227:493\u2013507","journal-title":"J Cell Physiol"},{"key":"9822_CR35","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.exppara.2011.08.016","volume":"129","author":"KC Glaser","year":"2011","unstructured":"Glaser KC, Hagos B, Molestina RE (2011) Effects of Toxoplasma gondii genotype and absence of host MAL\/Myd88 on the temporal regulation of gene expression in infected microglial cells. Exp Parasitol 129:409\u2013413","journal-title":"Exp Parasitol"},{"key":"9822_CR36","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/YCO.0000000000000152","volume":"28","author":"DC Goff","year":"2015","unstructured":"Goff DC (2015) Drug development in schizophrenia: are glutamatergic targets still worth aiming at? Curr Opin Psychiatr 28:207\u2013215","journal-title":"Curr Opin Psychiatr"},{"issue":"2","key":"9822_CR37","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1645\/GE-1331.1","volume":"94","author":"DG Goodwin","year":"2008","unstructured":"Goodwin DG, Strobl J, Mitchell SM, Zajac AM, Lindsay DS (2008) Evaluation of the mood-stabilizing agent valproic acid as a preventative for toxoplasmosis in mice and activity against tissue cysts in mice. J Parasitol 94(2):555\u2013557","journal-title":"J Parasitol"},{"issue":"1","key":"9822_CR38","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1645\/GE-2536.1","volume":"97","author":"DG Goodwin","year":"2011","unstructured":"Goodwin DG, Strobl JS, Lindsay DS (2011) Evaluation of five antischizophrenic agents against Toxoplasma gondii in human cell cultures. J Parasitol 97(1):148\u2013151","journal-title":"J Parasitol"},{"key":"9822_CR39","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/978-1-4615-0135-0_16","volume":"527","author":"P Guidetti","year":"2003","unstructured":"Guidetti P, Schwarcz R (2003) 3-Hydroxykynurenine and quinolinate: pathogenic synergism in early grade Huntington\u2019s disease? Adv Exp Med Biol 527:137\u2013145","journal-title":"Adv Exp Med Biol"},{"key":"9822_CR40","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/glia.20090","volume":"49","author":"GJ Guillemin","year":"2005","unstructured":"Guillemin GJ, Smythe G, Takikawa O, Brew BJ (2005) Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons. Glia 49:15\u201323","journal-title":"Glia"},{"key":"9822_CR41","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1159\/000089622","volume":"2","author":"GJ Guillemin","year":"2006","unstructured":"Guillemin GJ, Meininger V, Brew BJ (2006) Implications for the kynurenine pathway and quinolinic acid in amyotrophic lateral sclerosis. Neurodegener Dis 2:166\u2013176","journal-title":"Neurodegener Dis"},{"issue":"2","key":"9822_CR42","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jmb.2009.10.072","volume":"395","author":"Q Guo","year":"2010","unstructured":"Guo Q, Manolopoulou M, Bian Y, Schilling AB, Tang WJ (2010) Molecular basis for the recognition and cleavages of IGF-II, TGF-alpha, and amylin by human insulin-degrading enzyme. J Mol Biol 395(2):430\u2013443","journal-title":"J Mol Biol"},{"key":"9822_CR43","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.euroneuro.2011.08.008","volume":"21","author":"A Gustavsson","year":"2011","unstructured":"Gustavsson A, Svensson M, Jacobi F, Allgulander C, Alonso J, Beghi E, Dodel R, Ekman M, Faravelli C, Fratiglioni L, Gannon B, Jones DH, Jennum P, Jordanova A, J\u00f6nsson L, Karampampa K, Knapp M, Kobelt G, Kurth T, Lieb R, Linde M, Ljungcrantz C, Maercker A, Melin B, Moscarelli M, Musayev A, Norwood F, Preisig M, Pugliatti M, Rehm J, Salvador-Carulla L, Schlehofer B, Simon R, Steinhausen HC, Stovner LJ, Vallat JM, Van den Bergh P, van Os J, Vos P, Xu W, Wittchen HU, J\u00f6nsson B, Olesen J, CDBE2010Study Group (2011) Cost of disorders of the brain in Europe 2010. Eur Neuropsychopharmacol 21:718\u2013779","journal-title":"Eur Neuropsychopharmacol"},{"issue":"2","key":"9822_CR44","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1600-0854.2011.01308.x","volume":"13","author":"BE Hajagos","year":"2012","unstructured":"Hajagos BE, Turetzky JM, Peng ED, Cheng SJ, Ryan CM, Souda P, Whitelegge JP, Lebrun M, Dubremetz JF, Bradley PJ (2012) Molecular dissection of novel trafficking and processing of the Toxoplasma gondii rhoptry metalloprotease toxolysin-1. Traffic 13(2):292\u2013304","journal-title":"Traffic"},{"issue":"7","key":"9822_CR45","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1096\/fj.03-0764fje","volume":"18","author":"A Hans","year":"2004","unstructured":"Hans A, Bajramovic JJ, Syan S, Perret E, Dunia I, Brahic M, Gonzalez-Dunia D (2004) Persistent, noncytolytic infection of neurons by Borna disease virus interferes with ERK 1\/2 signaling and abrogates BDNF-induced synaptogenesis. FASEB J 18(7):863\u2013865","journal-title":"FASEB J"},{"key":"9822_CR46","doi-asserted-by":"crossref","first-page":"6114","DOI":"10.1111\/mec.12888","volume":"23","author":"SA Hari Dass","year":"2014","unstructured":"Hari Dass SA, Vyas A (2014) Toxoplasma gondii infection reduces predator aversion in rats through epigenetic modulation in the host medial amygdala. Mol Ecol 23:6114\u20136122","journal-title":"Mol Ecol"},{"key":"9822_CR47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035516","volume":"7","author":"F Haroon","year":"2012","unstructured":"Haroon F, H\u00e4ndel U, Angenstein F, Goldschmidt J, Kreutzmann P, Lison H, Fischer KD, Scheich H, Wetzel W, Schl\u00fcter D, Budinger E (2012) Toxoplasma gondii actively inhibits neuronal function in chronically infected mice. PLoS One 7, e35516","journal-title":"PLoS One"},{"key":"9822_CR48","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/brain\/122.4.593","volume":"122","author":"PJ Harrison","year":"1999","unstructured":"Harrison PJ (1999) The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain 122:593\u2013624","journal-title":"Brain"},{"key":"9822_CR49","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1093\/schbul\/sbm010","volume":"33","author":"D Hinze-Selch","year":"2007","unstructured":"Hinze-Selch D, D\u00e4ubener W, Eggert L, Erdag S, Stoltenberg R, Wilms S (2007) A controlled prospective study of toxoplasma gondii infection in individuals with schizophrenia: beyond seroprevalence. Schizophr Bull 33:782\u2013788","journal-title":"Schizophr Bull"},{"key":"9822_CR50","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/acps.12031","volume":"127","author":"D Holub","year":"2013","unstructured":"Holub D, Flegr J, Dragomireck\u00e1 E, Rodriguez M, Preiss M, Nov\u00e1k T, \u010cerm\u00e1k J, Hor\u00e1\u010dek J, Kodym P, Libiger J, H\u00f6schl C, Motlov\u00e1 LB (2013) Differences in onset of disease and severity of psychopathology between toxoplasmosis-related and toxoplasmosis-unrelated schizophrenia. Acta Psychiatr Scand 127:227\u2013238","journal-title":"Acta Psychiatr Scand"},{"key":"9822_CR51","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3109\/15622975.2011.573809","volume":"13","author":"J Horacek","year":"2012","unstructured":"Horacek J, Flegr J, Tintera J, Verebova K, Spaniel F, Novak T, Brunovsky M, Bubenikova-Valesova V, Holub D, Palenicek T, H\u00f6schl C (2012) Latent toxoplasmosis reduces gray matter density in schizophrenia but not in controls: voxel-based-morphometry (VBM) study. World J Biol Psychiatry 13:501\u2013509","journal-title":"World J Biol Psychiatry"},{"key":"9822_CR52","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1177\/0269881114563634","volume":"29","author":"O Howes","year":"2015","unstructured":"Howes O, McCutcheon R, Stone J (2015) Glutamate and dopamine in schizophrenia: an update for the 21st century. J Psychopharmacol 29:97\u2013115","journal-title":"J Psychopharmacol"},{"key":"9822_CR53","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/nrmicro2858","volume":"10","author":"CA Hunter","year":"2012","unstructured":"Hunter CA, Sibley LD (2012) Modulation of innate immunity by Toxoplasma gondii virulence effectors. Nat Rev Microbiol 10:766\u2013778","journal-title":"Nat Rev Microbiol"},{"key":"9822_CR54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0075246","volume":"8","author":"WM Ingram","year":"2013","unstructured":"Ingram WM, Goodrich LM, Robey EA, Eisen MB (2013) Mice infected with low-virulence strains of Toxoplasma gondii lose their innate aversion to cat urine, even after extensive parasite clearance. PLoS One 8, e75246","journal-title":"PLoS One"},{"issue":"3","key":"9822_CR55","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1086\/499312","volume":"193","author":"MR Jones","year":"2006","unstructured":"Jones MR, Quinton LJ, Simms BT, Lupa MM, Kogan MS, Mizgerd JP (2006) Roles of interleukin-6 in activation of STAT proteins and recruitment of neutrophils during Escherichia coli pneumonia. J Infect Dis 193(3):360\u2013369","journal-title":"J Infect Dis"},{"issue":"3","key":"9822_CR56","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0920-9964(02)00357-2","volume":"62","author":"L Jones-Brando","year":"2003","unstructured":"Jones-Brando L, Torrey EF, Yolken R (2003) Drugs used in the treatment of schizophrenia and bipolar disorder inhibit the replication of Toxoplasma gondii. Schizophr Res 62(3):237\u2013244","journal-title":"Schizophr Res"},{"issue":"3","key":"9822_CR57","volume":"7","author":"BK Jung","year":"2012","unstructured":"Jung BK, Pyo KH, Shin KY, Hwang YS, Lim H, Lee SJ, Moon JH, Lee SH, Suh YH, Chai JY, Shin EH (2012) Toxoplasma gondii infection in the brain inhibits neuronal degeneration and learning and memory impairments in a murine model of Alzheimer\u2019s disease. PLoS ONE 7(3), e33312","journal-title":"PLoS ONE"},{"issue":"7","key":"9822_CR58","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1176\/appi.ps.51.7.903","volume":"51","author":"SC Kalichman","year":"2000","unstructured":"Kalichman SC, Heckman T, Kochman A, Sikkema K, Bergholte J (2000) Depression and thoughts of suicide among middle-aged and older persons living with HIV-AIDS. Psychiatr Serv 51(7):903\u2013907","journal-title":"Psychiatr Serv"},{"key":"9822_CR59","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4137\/IJTR.S16800","volume":"7","author":"ME Kegel","year":"2014","unstructured":"Kegel ME, Bhat M, Skogh E, Samuelsson M, Lundberg K, Dahl ML, Sellgren C, Schwieler L, Engberg G, Schuppe-Koistinen I, Erhardt S (2014) Imbalanced kynurenine pathway in schizophrenia. Int J Tryptophan Res 7:15\u201322","journal-title":"Int J Tryptophan Res"},{"key":"9822_CR60","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/schbul\/19.2.261","volume":"19","author":"KS Kendler","year":"1993","unstructured":"Kendler KS, Diehl SR (1993) The genetics of schizophrenia: a current, genetic-epidemiologic perspective. Schizophr Bull 19:261\u2013284","journal-title":"Schizophr Bull"},{"key":"9822_CR61","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1007\/s00259-003-1245-7","volume":"30","author":"CH Kim","year":"2003","unstructured":"Kim CH, Koo MS, Cheon KA, Ryu YH, Lee JD, Lee HS (2003) Dopamine transporter density of basal ganglia assessed with [123I] IPT SPET in obsessive\u2013compulsive disorder. Eur J Nucl Med Mol Imaging 30:1637\u20131643","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"9822_CR62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/WAD.0b013e3181f73bc2","volume":"25","author":"OY Kusbeci","year":"2011","unstructured":"Kusbeci OY, Miman O, Yaman M, Aktepe OC, Yazar S (2011) Could Toxoplasma gondii have any role in Alzheimer disease? Alzheimer Dis Assoc Disord 25:1\u20133","journal-title":"Alzheimer Dis Assoc Disord"},{"issue":"2","key":"9822_CR63","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.neubiorev.2011.12.005","volume":"36","author":"B Leonard","year":"2012","unstructured":"Leonard B, Maes M (2012) Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression. Neurosci Biobehav Rev 36(2):764\u2013785","journal-title":"Neurosci Biobehav Rev"},{"issue":"6","key":"9822_CR64","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.4049\/jimmunol.177.6.3644","volume":"177","author":"H Li","year":"2006","unstructured":"Li H, Gang Z, Yuling H, Luokun X, Jie X, Hao L et al (2006) Different neurotropic pathogens elicit neurotoxic CCR9- or neurosupportive CXCR3-expressing microglia. J Immunol 177(6):3644\u20133656","journal-title":"J Immunol"},{"key":"9822_CR65","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/mec.12042","volume":"22","author":"A Lim","year":"2013","unstructured":"Lim A, Kumar V, Hari Dass SA, Vyas A (2013) Toxoplasma gondii infection enhances testicular steroidogenesis in rats. Mol Ecol 22:102\u2013110","journal-title":"Mol Ecol"},{"issue":"2","key":"9822_CR66","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/ng1071","volume":"33","author":"KE Lohmueller","year":"2003","unstructured":"Lohmueller KE, Pearce CL, Pike M, Lander ES, Hirschhorn JN (2003) Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet 33(2):177\u2013182","journal-title":"Nat Genet"},{"key":"9822_CR67","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.nbd.2003.12.015","volume":"15","author":"CL Miller","year":"2004","unstructured":"Miller CL, Llenos IC, Dulay JR, Barillo MM, Yolken RH, Weis S (2004) Expression of the kynurenine pathway enzyme tryptophan 2,3-dioxygenase is increased in the frontal cortex of individuals with schizophrenia. Neurobiol Dis 15:618\u2013629","journal-title":"Neurobiol Dis"},{"key":"9822_CR68","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ijpara.2008.08.002","volume":"39","author":"CM Miller","year":"2009","unstructured":"Miller CM, Boulter NR, Ikin RJ, Smith NC (2009) The immunobiology of the innate response to Toxoplasma gondii. Int J Parasitol 39:23\u201339","journal-title":"Int J Parasitol"},{"key":"9822_CR69","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.biopsych.2011.04.013","volume":"70","author":"BJ Miller","year":"2011","unstructured":"Miller BJ, Buckley P, Seabolt W, Mellor A, Kirkpatrick B (2011) Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects. Biol Psychiatry 70:663\u2013671","journal-title":"Biol Psychiatry"},{"key":"9822_CR70","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.neulet.2010.03.057","volume":"475","author":"O Miman","year":"2010","unstructured":"Miman O, Kusbeci OY, Aktepe OC, Cetinkaya Z (2010) The probable relation between Toxoplasma gondii and Parkinson\u2019s disease. Neurosci Lett 475:129\u2013131","journal-title":"Neurosci Lett"},{"key":"9822_CR71","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1242\/dmm.009928","volume":"6","author":"R Mitra","year":"2013","unstructured":"Mitra R, Sapolsky RM, Vyas A (2013) Toxoplasma gondii infection induces dendritic retraction in basolateral amygdala accompanied by reduced corticosterone secretion. Dis Model Mech 6:516\u2013520","journal-title":"Dis Model Mech"},{"key":"9822_CR72","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/S0140-6736(04)16412-X","volume":"363","author":"JG Montoya","year":"2004","unstructured":"Montoya JG, Liesenfeld O (2004) Toxoplasmosis. Lancet 363:1965\u20131976","journal-title":"Lancet"},{"issue":"3","key":"9822_CR73","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1093\/schbul\/sbm009","volume":"33","author":"PB Mortensen","year":"2007","unstructured":"Mortensen PB, N\u00f8rgaard-Pedersen B, Waltoft BL, S\u00f8rensen TL, Hougaard D, Yolken RH (2007) Early infections of Toxoplasma gondii and the later development of schizophrenia. Schizophr Bull 33(3):741\u2013744","journal-title":"Schizophr Bull"},{"key":"9822_CR74","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1111\/j.1460-9568.2009.06946.x","volume":"30","author":"X Mou","year":"2009","unstructured":"Mou X, Peterson CB, Prosser RA (2009) Tissue-type plasminogen activator-plasmin-BDNF modulate glutamate-induced phase-shifts of the mouse suprachiasmatic circadian clock in vitro. Eur J Neurosci 30:1451\u20131460","journal-title":"Eur J Neurosci"},{"key":"9822_CR75","doi-asserted-by":"crossref","unstructured":"Notarangelo FM, Wilson EH, Horning KJ, Thomas MA, Harris TH, Fang Q, Hunter CA, Schwarcz R (2014) Evaluation of kynurenine pathway metabolism in Toxoplasma gondii-infected mice: implications for schizophrenia. Schizophr Res 152:261\u2013267","DOI":"10.1016\/j.schres.2013.11.011"},{"key":"9822_CR77","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.tips.2011.08.003","volume":"32","author":"KK Ogden","year":"2011","unstructured":"Ogden KK, Traynelis SF (2011) New advances in NMDA receptor pharmacology. Trends Pharmacol Sci 32:726\u2013733","journal-title":"Trends Pharmacol Sci"},{"key":"9822_CR78","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.biopsych.2006.09.012","volume":"62","author":"P Okulski","year":"2007","unstructured":"Okulski P, Jay TM, Jaworski J, Duniec K, Dzwonek J, Konopacki FA, Wilczynski GM, S\u00e1nchez-Capelo A, Mallet J, Kaczmarek L (2007) TIMP-1 abolishes MMP-9-dependent long-lasting long-term potentiation in the prefrontal cortex. Biol Psychiatry 62:359\u2013362","journal-title":"Biol Psychiatry"},{"key":"9822_CR79","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jpsychires.2015.10.002","volume":"72","author":"O Okusaga","year":"2016","unstructured":"Okusaga O, Duncan E, Langenberg P, Brundin L, Fuchs D, Groer MW, Giegling I, Stearns-Yoder KA, Hartmann AM, Konte B, Friedl M, Brenner LA, Lowry CA, Rujescu D, Postolache TT (2016) Combined Toxoplasma gondii seropositivity and high blood kynurenine - Linked with nonfatal suicidal self-directed violence in patients with schizophrenia. J Psychiatr Res 72:74\u201381","journal-title":"J Psychiatr Res"},{"issue":"3","key":"9822_CR80","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/pim.12157","volume":"37","author":"A Parlog","year":"2015","unstructured":"Parlog A, Schl\u00fcter D, Dunay IR (2015) Toxoplasma gondii-induced neuronal alterations. Parasite Immunol 37(3):159\u2013710","journal-title":"Parasite Immunol"},{"issue":"3","key":"9822_CR81","doi-asserted-by":"crossref","first-page":"R98","DOI":"10.1016\/j.cub.2015.12.020","volume":"26","author":"C Poirotte","year":"2016","unstructured":"Poirotte C, Kappeler PM, Ngoubangoye B, Bourgeois S, Moussodji M, Charpentier MJ (2016) Morbid attraction to leopard urine in Toxoplasma-infected chimpanzees. Curr Biol 26(3):R98\u20139","journal-title":"Curr Biol"},{"key":"9822_CR82","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.rasd.2009.09.007","volume":"4","author":"J Prandota","year":"2010","unstructured":"Prandota J (2010) Neuropathological changes and clinical features of autism spectrum disorder participants are similar to that reported in congenital and chronic cerebral toxoplasmosis in humans and mice. Res Autism Spect Disord 4:103\u2013118","journal-title":"Res Autism Spect Disord"},{"issue":"9","key":"9822_CR83","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0023866","volume":"6","author":"E Prandovszky","year":"2011","unstructured":"Prandovszky E, Gaskell E, Martin H, Dubey JP, Webster JP, McConkey GA (2011) The neurotropic parasite Toxoplasma gondii increases dopamine metabolism. PLoS One 6(9), e23866","journal-title":"PLoS One"},{"key":"9822_CR84","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0002-9440(10)61191-1","volume":"167","author":"C Rozenfeld","year":"2005","unstructured":"Rozenfeld C, Martinez R, Seabra S, Sant\u2019anna C, Gon\u00e7alves JG, Bozza M, Moura-Neto V, De Souza W (2005) Toxoplasma gondii prevents neuron degeneration by interferon-gamma-activated microglia in a mechanism involving inhibition of inducible nitric oxide synthase and transforming growth factor-beta1 production by infected microglia. Am J Pathol 167:1021\u20131031","journal-title":"Am J Pathol"},{"issue":"5806","key":"9822_CR85","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1126\/science.1133690","volume":"314","author":"JP Saeij","year":"2006","unstructured":"Saeij JP, Boyle JP, Coller S, Taylor S, Sibley LD, Brooke-Powell ET, Ajioka JW, Boothroyd JC (2006) Polymorphic secreted kinases are key virulence factors in toxoplasmosis. Science 314(5806):1780\u20131783","journal-title":"Science"},{"key":"9822_CR86","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1093\/schbul\/sbm030","volume":"33","author":"R Schwarcz","year":"2007","unstructured":"Schwarcz R, Hunter CA (2007) Toxoplasma gondii and schizophrenia: linkage through astrocyte-derived kynurenic acid? Schizophr Bull 33:652\u2013653","journal-title":"Schizophr Bull"},{"key":"9822_CR87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/jpet.102.034439","volume":"303","author":"R Schwarcz","year":"2002","unstructured":"Schwarcz R, Pellicciari R (2002) Manipulation of brain kynurenines: glial targets, neuronal effects, and clinical opportunities. J Pharmacol Exp Ther 303:1\u201310","journal-title":"J Pharmacol Exp Ther"},{"key":"9822_CR88","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0006-3223(01)01078-2","volume":"50","author":"R Schwarcz","year":"2001","unstructured":"Schwarcz R, Rassoulpour A, Wu HQ, Medoff D, Tamminga CA, Roberts RC (2001) Increased cortical kynurenate content in schizophrenia. Biol Psychiatry 50:521\u2013530","journal-title":"Biol Psychiatry"},{"issue":"3","key":"9822_CR89","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2190\/0KUX-JE1J-HV6K-3R9J","volume":"35","author":"UB Semiz","year":"2005","unstructured":"Semiz UB, Turhan V, Basoglu C, Oner O, Ebrinc S, Cetin M (2005) Leptospirosis presenting with mania and psychosis: four consecutive cases seen in a military hospital in Turkey. Int J Psychiatry Med 35(3):299\u2013305","journal-title":"Int J Psychiatry Med"},{"issue":"Pt 5","key":"9822_CR90","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1017\/S0031182006000886","volume":"133","author":"A Skallov\u00e1","year":"2006","unstructured":"Skallov\u00e1 A, Kodym P, Frynta D, Flegr J (2006) The role of dopamine in Toxoplasma-induced behavioural alterations in mice: an ethological and ethopharmacological study. Parasitology 133(Pt 5):525\u2013535","journal-title":"Parasitology"},{"issue":"2","key":"9822_CR91","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/00034983.1985.11811902","volume":"79","author":"HH Stibbs","year":"1985","unstructured":"Stibbs HH (1985) Changes in brain concentrations of catecholamines and indoleamines in Toxoplasma gondii infected mice. Ann Trop Med Parasitol 79(2):153\u2013157","journal-title":"Ann Trop Med Parasitol"},{"issue":"6","key":"9822_CR92","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1645\/GE-2760.1","volume":"98","author":"JS Strobl","year":"2012","unstructured":"Strobl JS, Goodwin DG, Rzigalinski BA, Lindsay DS (2012) Dopamine stimulates propagation of Toxoplasma gondii tachyzoites in human fibroblast and primary neonatal rat astrocyte cell cultures. J Parasitol 98(6):1296\u20131299","journal-title":"J Parasitol"},{"key":"9822_CR93","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1001\/archpsyc.60.12.1187","volume":"60","author":"PF Sullivan","year":"2003","unstructured":"Sullivan PF, Kendler KS, Neale MC (2003) Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch Gen Psychiatry 60:1187\u20131192","journal-title":"Arch Gen Psychiatry"},{"issue":"1","key":"9822_CR94","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1471-4159.2007.04670.x","volume":"103","author":"GY Sun","year":"2007","unstructured":"Sun GY, Horrocks LA, Farooqui AA (2007) The roles of NADPH oxidase and phospholipases A2 in oxidative and inflammatory responses in neurodegenerative diseases. J Neurochem 103(1):1\u201316","journal-title":"J Neurochem"},{"issue":"3","key":"9822_CR95","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/acps.12423","volume":"132","author":"AL Sutterland","year":"2015","unstructured":"Sutterland AL, Fond G, Kuin A, Koeter MWJ, Lutter R, vanGool T, Yolken R, Szoke A, Leboyer M, deHaan L (2015) Beyond the association. Toxoplasma gondii in schizophrenia, bipolar disorder, and addiction: systematic review and meta-analysis. Acta Psychiatr Scand 132(3):161\u201379","journal-title":"Acta Psychiatr Scand"},{"key":"9822_CR96","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.psychres.2011.07.006","volume":"189","author":"J Suvisaari","year":"2011","unstructured":"Suvisaari J, Loo BM, Saarni SE, Haukka J, Per\u00e4l\u00e4 J, Saarni SI, Vierti\u00f6 S, Partti K, L\u00f6nnqvist J, Jula A (2011) Inflammation in psychotic disorders: a population-based study. Psychiatry Res 189:305\u2013311","journal-title":"Psychiatry Res"},{"key":"9822_CR97","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ijpara.2004.10.020","volume":"35","author":"Y Suzuki","year":"2005","unstructured":"Suzuki Y, Claflin J, Wang X, Lengi A, Kikuchi T (2005) Microglia and macrophages as innate producers of interferon-gamma in the brain following infection with Toxoplasma gondii. Int J Parasitol 35:83\u201390","journal-title":"Int J Parasitol"},{"key":"9822_CR98","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1542\/peds.113.4.907","volume":"113","author":"SE Swedo","year":"2004","unstructured":"Swedo SE, Leonard HL, Rapoport JL (2004) The pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS) subgroup: separating fact from fiction. Pediatrics 113:907\u2013111","journal-title":"Pediatrics"},{"issue":"1","key":"9822_CR99","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.psychres.2011.05.029","volume":"198","author":"W Taboas","year":"2012","unstructured":"Taboas W, McKay D, Taylor S (2012) Does Toxoplasma gondii play a role in obsessive-compulsive disorder? Psychiatry Res 198(1):176\u2013177","journal-title":"Psychiatry Res"},{"key":"9822_CR100","first-page":"2200","volume":"118","author":"HY Tan","year":"2008","unstructured":"Tan HY, Nicodemus KK, Chen Q, Li Z, Brooke JK, Honea R, Kolachana BS, Straub RE, Meyer-Lindenberg A, Sei Y, Mattay VS, Callicott JH, Weinberger DR (2008) Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humans. J Clin Invest 118:2200\u20132208","journal-title":"J Clin Invest"},{"key":"9822_CR101","doi-asserted-by":"crossref","unstructured":"Tomasik J, Schultz TL, Kluge W, Yolken RH, Bahn S, Carruthers VB (2015) Shared immune and repair markers during experimental Toxoplasma chronic brain infection and schizophrenia. Schizophr Bull","DOI":"10.1093\/schbul\/sbv134"},{"key":"9822_CR102","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.biopsych.2008.04.025","volume":"64","author":"BN Berckel Van","year":"2008","unstructured":"Van Berckel BN, Bossong MG, Boellaard R, Kloet R, Schuitemaker A, Caspers E, Luurtsema G, Windhorst AD, Cahn W, Lammertsma AA, Kahn RS (2008) Microglia activation in recent-onset schizophrenia: a quantitative (R)-[11C]PK11195 positron emission tomography study. Biol Psychiatry 64:820\u2013822","journal-title":"Biol Psychiatry"},{"key":"9822_CR103","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0140-6736(09)60995-8","volume":"374","author":"J Os Van","year":"2009","unstructured":"Van Os J, Kapur S (2009) Schizophrenia. Lancet 374:635\u2013645","journal-title":"Lancet"},{"key":"9822_CR104","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1742-2094-11-85","volume":"11","author":"AR Vasconcelos","year":"2014","unstructured":"Vasconcelos AR, Yshii LM, Viel TA, Buck HS, Mattson MP, Scavone C, Kawamoto EM (2014) Intermittent fasting attenuates lipopolysaccharide-induced neuroinflammation and memory impairment. J Neuroinflammation 11:85","journal-title":"J Neuroinflammation"},{"issue":"6","key":"9822_CR105","first-page":"749","volume":"8","author":"P Vega","year":"2004","unstructured":"Vega P, Sweetland A, Acha J, Castillo H, Guerra D, Smith Fawzi MC, Shin S (2004) Psychiatric issues in the management of patients with multidrug-resistant tuberculosis. Int J Tuberc Lung Dis 8(6):749\u2013759","journal-title":"Int J Tuberc Lung Dis"},{"key":"9822_CR106","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1467-789X.2012.01031.x","volume":"14","author":"ND Volkow","year":"2013","unstructured":"Volkow ND, Wang GJ, Tomasi D, Baler RD (2013) Obesity and addiction: neurobiological overlaps. Obes Rev 14:2\u201318","journal-title":"Obes Rev"},{"key":"9822_CR107","doi-asserted-by":"crossref","first-page":"6442","DOI":"10.1073\/pnas.0608310104","volume":"104","author":"A Vyas","year":"2007","unstructured":"Vyas A, Kim KS, Giacomini N, Boothroyd JC, Sapolsky RM (2007) Behvioral changes induced by Toxoplasma infection of rodents are highly specific to aversion of cat odors. Proc Natl Acad Sci U S A 104:6442\u20136447","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9822_CR108","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1089\/jir.2006.0154","volume":"27","author":"X Wang","year":"2007","unstructured":"Wang X, Michie SA, Xu B, Suzuki Y (2007) Importance of IFN-gamma-mediated expression of endothelial VCAM-1 on recruitment of CD8+ T cells into the brain during chronic infection with Toxoplasma gondii. J Interferon Cytokine Res 27:329\u2013338","journal-title":"J Interferon Cytokine Res"},{"issue":"1589","key":"9822_CR109","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1098\/rspb.2005.3413","volume":"273","author":"JP Webster","year":"2006","unstructured":"Webster JP, Lamberton PH, Donnelly CA, Torrey EF (2006) Parasites as causative agents of human affective disorders? The impact of anti-psychotic, mood-stabilizer and anti-parasite medication on Toxoplasma gondii\u2019s ability to alter host behaviour. Proc Biol Sci 273(1589):1023\u20131030","journal-title":"Proc Biol Sci"},{"key":"9822_CR110","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1136\/jnnp.70.3.419","volume":"70","author":"B Widner","year":"2001","unstructured":"Widner B, Fuchs D, Leblhuber F, Sperner-Unterweger B (2001) Does disturbed homocysteine and folate metabolism in depression result from enhanced oxidative stress? J Neurol Neurosurg Psychiatry 70:419","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"9822_CR111","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.immuni.2008.12.013","volume":"30","author":"EH Wilson","year":"2009","unstructured":"Wilson EH, Harris TH, Mrass P, John B, Tait ED, Wu GF, Pepper M, Wherry EJ, Dzierzinski F, Roos D, Haydon PG, Laufer TM, Weninger W, Hunter CA (2009) Behavior of parasite-specific effector CD8+ T cells in the brain and visualization of a kinesis-associated system of reticular fibers. Immunity 30:300\u2013311","journal-title":"Immunity"},{"issue":"12","key":"9822_CR112","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1007\/s00702-013-1064-3","volume":"120","author":"J Xiao","year":"2013","unstructured":"Xiao J, Li Y, Jones-Brando L, Yolken RH (2013) Abnormalities of neurotransmitter and neuropeptide systems in human neuroepithelioma cells infected by three Toxoplasma strains. J Neural Transm (Vienna) 120(12):1631\u20131639","journal-title":"J Neural Transm (Vienna)"},{"issue":"3","key":"9822_CR113","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s12639-013-0382-6","volume":"39","author":"KH Zghair","year":"2015","unstructured":"Zghair KH, AL-Qadhi BN, Mahmood SH (2015) The effect of toxoplasmosis on the level of some sex hormones in males blood donors in Baghdad. J Parasit Dis 39(3):393\u2013400","journal-title":"J Parasit Dis"},{"issue":"10","key":"9822_CR114","volume":"10","author":"CX Zhou","year":"2015","unstructured":"Zhou CX, Zhou DH, Elsheikha HM, Liu GX, Suo X, Zhu XQ (2015) Global metabolomic profiling of mice brains following experimental infection with the cyst-forming Toxoplasma gondii. PLoS One 10(10), e0139635","journal-title":"PLoS One"},{"key":"9822_CR115","doi-asserted-by":"crossref","first-page":"19557","DOI":"10.1038\/srep19557","volume":"6","author":"CX Zhou","year":"2016","unstructured":"Zhou CX, Zhou DH, Elsheikha HM, Zhao Y, Suo X, Zhu XQ (2016) Metabolomic profiling of mice serum during toxoplasmosis progression using liquid chromatography-mass spectrometry. Sci Rep 6:19557","journal-title":"Sci Rep"},{"key":"9822_CR116","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.bpa.2010.11.001","volume":"24","author":"E Zindler","year":"2010","unstructured":"Zindler E, Zipp F (2010) Neuronal injury in chronic CNS inflammation. Best Pract Res Clin Anaesthesiol 24:551\u2013562","journal-title":"Best Pract Res Clin Anaesthesiol"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-016-9822-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11011-016-9822-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-016-9822-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T13:01:11Z","timestamp":1718456471000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11011-016-9822-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,4]]},"references-count":115,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["9822"],"URL":"https:\/\/doi.org\/10.1007\/s11011-016-9822-1","relation":{},"ISSN":["0885-7490","1573-7365"],"issn-type":[{"value":"0885-7490","type":"print"},{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,4]]}}}