{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T17:58:48Z","timestamp":1784224728036,"version":"3.55.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T00:00:00Z","timestamp":1465516800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Polish Ministry of Science and Higher Education","award":["IP 2014 043373"],"award-info":[{"award-number":["IP 2014 043373"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1007\/s11011-016-9852-8","type":"journal-article","created":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T01:48:10Z","timestamp":1465523290000},"page":"1095-1104","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Antidepressant-like activity of sildenafil following acute and subchronic treatment in the forced swim test in mice: effects of restraint stress and monoamine depletion"],"prefix":"10.1007","volume":"31","author":[{"given":"Katarzyna","family":"Soca\u0142a","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Nieoczym","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz","family":"Pier\u00f3g","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Szuster-Ciesielska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u017cbieta","family":"Wyska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Wla\u017a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,6,10]]},"reference":[{"key":"9852_CR1","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.bbr.2005.11.023","volume":"168","author":"RC Almeida","year":"2006","unstructured":"Almeida RC, Felisbino CS, Lopez MG, Rodrigues AL, Gabilan NH (2006) Evidence for the involvement of L-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of memantine in mice. Behav Brain Res 168:318\u2013322","journal-title":"Behav Brain Res"},{"key":"9852_CR2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.physbeh.2013.05.012","volume":"118","author":"OV Bogdanova","year":"2013","unstructured":"Bogdanova OV, Kanekar S, D'Anci KE, Renshaw PF (2013) Factors influencing behavior in the forced swim test. Physiol Behav 118:227\u2013239","journal-title":"Physiol Behav"},{"key":"9852_CR3","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s00702-007-0806-5","volume":"115","author":"CB Brink","year":"2008","unstructured":"Brink CB, Clapton JD, Eagar BE, Harvey BH (2008) Appearance of antidepressant-like effect by sildenafil in rats after central muscarinic receptor blockade: evidence from behavioural and neuro-receptor studies. J Neural Transm 115:117\u2013125","journal-title":"J Neural Transm"},{"key":"9852_CR4","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ejphar.2008.08.033","volume":"598","author":"PS Brocardo","year":"2008","unstructured":"Brocardo PS, Budni J, Lobato KR, Kaster MP, Rodrigues AL (2008) Antidepressant-like effect of folic acid: involvement of NMDA receptors and L-arginine-nitric oxide-cyclic guanosine monophosphate pathway. Eur J Pharmacol 598:37\u201342","journal-title":"Eur J Pharmacol"},{"key":"9852_CR5","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.bbr.2013.07.004","volume":"253","author":"H Dadomo","year":"2013","unstructured":"Dadomo H, Parmigiani S, Nicolini Y, Freschini S, Gioiosa L, Patrelli TS, Palanza P, Volpi R (2013) Repeated and chronic administration of Vardenafil or sildenafil differentially affects emotional and socio-sexual behavior in mice. Behav Brain Res 253:103\u2013112","journal-title":"Behav Brain Res"},{"key":"9852_CR6","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ejphar.2007.04.028","volume":"568","author":"A Dhir","year":"2007","unstructured":"Dhir A, Kulkarni SK (2007) Involvement of nitric oxide (NO) signaling pathway in the antidepressant action of bupropion, a dopamine reuptake inhibitor. Eur J Pharmacol 568:177\u2013185","journal-title":"Eur J Pharmacol"},{"key":"9852_CR7","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.niox.2011.02.002","volume":"24","author":"A Dhir","year":"2011","unstructured":"Dhir A, Kulkarni SK (2011) Nitric oxide and major depression. Nitric Oxide 24:125\u2013131","journal-title":"Nitric Oxide"},{"key":"9852_CR8","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.bbr.2015.03.064","volume":"287","author":"U Doboszewska","year":"2015","unstructured":"Doboszewska U, Szewczyk B, Sowa-Kucma M, Mlyniec K, Rafalo A, Ostachowicz B, Lankosz M, Nowak G (2015) Antidepressant activity of fluoxetine in the zinc deficiency model in rats involves the NMDA receptor complex. Behav Brain Res 287:323\u2013330","journal-title":"Behav Brain Res"},{"key":"9852_CR9","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0079-6123(08)60060-6","volume":"53","author":"E Endroczi","year":"1980","unstructured":"Endroczi E (1980) ACTH-like peptides, pituitary-adrenocortical function and avoidance behavior. Prog Brain Res 53:111\u2013121","journal-title":"Prog Brain Res"},{"key":"9852_CR10","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s002130000560","volume":"153","author":"AM Gardier","year":"2001","unstructured":"Gardier AM, Bourin M (2001) Appropriate use of \"knockout\" mice as models of depression or models of testing the efficacy of antidepressants. Psychopharmacology 153:393\u2013394","journal-title":"Psychopharmacology"},{"key":"9852_CR11","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.euroneuro.2007.07.011","volume":"18","author":"M Ghasemi","year":"2008","unstructured":"Ghasemi M, Sadeghipour H, Mosleh A, Sadeghipour HR, Mani AR, Dehpour AR (2008) Nitric oxide involvement in the antidepressant-like effects of acute lithium administration in the mouse forced swimming test. Eur Neuropsychopharmacol 18:323\u2013332","journal-title":"Eur Neuropsychopharmacol"},{"key":"9852_CR12","volume":"4","author":"M Guo","year":"2014","unstructured":"Guo M, Lu XY (2014) Leptin receptor deficiency confers resistance to behavioral effects of fluoxetine and desipramine via separable substrates. Transl Psychiatry 4:e486","journal-title":"Transl Psychiatry"},{"key":"9852_CR13","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.physbeh.2004.09.005","volume":"83","author":"AK Hotchkiss","year":"2005","unstructured":"Hotchkiss AK, Pyter LM, Gatien ML, Wen JC, Milman HA, Nelson RJ (2005) Aggressive behavior increases after termination of chronic sildenafil treatment in mice. Physiol Behav 83:683\u2013688","journal-title":"Physiol Behav"},{"key":"9852_CR14","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.lfs.2011.07.005","volume":"89","author":"B Karakoyun","year":"2011","unstructured":"Karakoyun B, Uslu U, Ercan F, Aydin MS, Yuksel M, Ogunc AV, Alican I (2011) The effect of phosphodiesterase-5 inhibition by sildenafil citrate on inflammation and apoptosis in rat experimental colitis. Life Sci 89:402\u2013407","journal-title":"Life Sci"},{"key":"9852_CR15","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1017\/S1461145705005316","volume":"8","author":"MP Kaster","year":"2005","unstructured":"Kaster MP, Rosa AO, Santos AR, Rodrigues AL (2005) Involvement of nitric oxide-cGMP pathway in the antidepressant-like effects of adenosine in the forced swimming test. Int J Neuropsychopharmacol 8:601\u2013606","journal-title":"Int J Neuropsychopharmacol"},{"key":"9852_CR16","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/j.1743-6109.2012.03000.x","volume":"10","author":"C Kyratsas","year":"2013","unstructured":"Kyratsas C, Dalla C, Anderzhanova E, Polissidis A, Kokras N, Konstantinides K, Papadopoulou-Daifoti Z (2013) Experimental evidence for sildenafil's action in the central nervous system: dopamine and serotonin changes in the medial preoptic area and nucleus accumbens during sexual arousal. J Sex Med 10:719\u2013729","journal-title":"J Sex Med"},{"key":"9852_CR17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.neuroscience.2011.11.001","volume":"200","author":"H Matsushita","year":"2012","unstructured":"Matsushita H, Matsuzaki M, Han XJ, Nishiki TI, Ohmori I, Michiue H, Matsui H, Tomizawa K (2012) Antidepressant-like effect of sildenafil through oxytocin-dependent cyclic AMP response element-binding protein phosphorylation. Neuroscience 200:13\u201318","journal-title":"Neuroscience"},{"key":"9852_CR18","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.pharmthera.2005.11.006","volume":"110","author":"MJ Millan","year":"2006","unstructured":"Millan MJ (2006) Multi-target strategies for the improved treatment of depressive states: conceptual foundations and neuronal substrates, drug discovery and therapeutic application. Pharmacol Ther 110:135\u2013370","journal-title":"Pharmacol Ther"},{"key":"9852_CR19","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0361-9230(03)00104-7","volume":"61","author":"G Nowak","year":"2003","unstructured":"Nowak G, Szewczyk B, Wiero\u0144ska JM, Bra\u0144ski P, Palucha A, Pilc A, Sadlik K, Piekoszewski W (2003) Antidepressant-like effects of acute and chronic treatment with zinc in forced swim test and olfactory bulbectomy model in rats. Brain Res Bull 61:159\u2013164","journal-title":"Brain Res Bull"},{"issue":"Suppl 10","key":"9852_CR20","first-page":"20","volume":"64","author":"HG Nurnberg","year":"2003","unstructured":"Nurnberg HG, Hensley PL (2003) Sildenafil citrate for the management of antidepressant-associated erectile dysfunction. J Clin Psychol 64(Suppl 10):20\u201325","journal-title":"J Clin Psychol"},{"key":"9852_CR21","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0090-4295(02)01691-6","volume":"60","author":"HG Nurnberg","year":"2002","unstructured":"Nurnberg HG, Seidman SN, Gelenberg AJ, Fava M, Rosen R, Shabsigh R (2002) Depression, antidepressant therapies, and erectile dysfunction: clinical trials of sildenafil citrate (Viagra) in treated and untreated patients with depression. Urology 60:58\u201366","journal-title":"Urology"},{"key":"9852_CR22","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00213-004-2048-7","volume":"177","author":"B Petit-Demouliere","year":"2005","unstructured":"Petit-Demouliere B, Chenu F, Bourin M (2005) Forced swimming test in mice: a review of antidepressant activity. Psychopharmacology 177:245\u2013255","journal-title":"Psychopharmacology"},{"key":"9852_CR23","first-page":"746","volume":"58","author":"E Poleszak","year":"2006","unstructured":"Poleszak E, Wla\u017a P, K\u0119dzierska E, Nieoczym D, Wyska E, Szymura-Oleksiak J, Fidecka S, Radziwo\u0144-Zaleska M, Nowak G (2006) Immobility stress induces depression-like behavior in the forced swim test in mice: effect of magnesium and imipramine. Pharmacol Rep 58:746\u2013752","journal-title":"Pharmacol Rep"},{"key":"9852_CR24","first-page":"327","volume":"229","author":"RD Porsolt","year":"1977","unstructured":"Porsolt RD, Bertin A, Jalfre M (1977) Behavioral despair in mice: a primary screening test for antidepressants. Arch Int Pharmacodyn Ther 229:327\u2013336","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"9852_CR25","doi-asserted-by":"crossref","first-page":"321460","DOI":"10.1155\/2013\/321460","volume":"2013","author":"C Raposo","year":"2013","unstructured":"Raposo C, Nunes AK, Luna RL, Araujo SM, Cruz-Hofling MA, Peixoto CA (2013) Sildenafil (Viagra) protective effects on neuroinflammation: the role of iNOS\/NO system in an inflammatory demyelination model. Mediat Inflamm 2013:321460","journal-title":"Mediat Inflamm"},{"key":"9852_CR26","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1080\/10532528.2002.10559802","volume":"13","author":"RC Rosen","year":"2002","unstructured":"Rosen RC, McKenna KE (2002) PDE-5 inhibition and sexual response: pharmacological mechanisms and clinical outcomes. Annu Rev Sex Res 13:36\u201388","journal-title":"Annu Rev Sex Res"},{"key":"9852_CR27","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.pbb.2007.09.015","volume":"88","author":"L Savegnago","year":"2008","unstructured":"Savegnago L, Jesse CR, Pinto LG, Rocha JB, Barancelli DA, Nogueira CW, Zeni G (2008) Diphenyl diselenide exerts antidepressant-like and anxiolytic-like effects in mice: involvement of L-arginine-nitric oxide-soluble guanylate cyclase pathway in its antidepressant-like action. Pharmacol Biochem Behav 88:418\u2013426","journal-title":"Pharmacol Biochem Behav"},{"key":"9852_CR28","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1176\/appi.ajp.158.10.1623","volume":"158","author":"SN Seidman","year":"2001","unstructured":"Seidman SN, Roose SP, Menza MA, Shabsigh R, Rosen RC (2001) Treatment of erectile dysfunction in men with depressive symptoms: results of a placebo-controlled trial with sildenafil citrate. Am J Psychiatry 158:1623\u20131630","journal-title":"Am J Psychiatry"},{"key":"9852_CR29","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S1734-1140(12)70922-2","volume":"64","author":"K Soca\u0142a","year":"2012","unstructured":"Soca\u0142a K, Nieoczym D, Poleszak E, Wla\u017a P (2012b) Influence of the phosphodiesterase type 5 inhibitor, sildenafil, on antidepressant-like activity of magnesium in the forced swim test in mice. Pharmacol Rep 64:205\u2013211","journal-title":"Pharmacol Rep"},{"key":"9852_CR30","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.pnpbp.2012.02.013","volume":"38","author":"K Soca\u0142a","year":"2012","unstructured":"Soca\u0142a K, Nieoczym D, Wyska E, Poleszak E, Wla\u017a P (2012a) Sildenafil, a phosphodiesterase type 5 inhibitor, enhances the activity of two atypical antidepressant drugs, mianserin and tianeptine, in the forced swim test in mice. Prog Neuro-Psychopharmacol Biol Psychiatry 38:121\u2013126","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"9852_CR31","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s00702-011-0756-9","volume":"119","author":"K Soca\u0142a","year":"2012","unstructured":"Soca\u0142a K, Nieoczym D, Wyska E, Poleszak E, Wla\u017a P (2012c) Sildenafil, a phosphodiesterase type 5 inhibitor, enhances the antidepressant activity of amitriptyline but not desipramine, in the forced swim test in mice. J Neural Transm 119:645\u2013652","journal-title":"J Neural Transm"},{"key":"9852_CR32","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/S1734-1140(12)70922-2","volume":"64","author":"K Soca\u0142a","year":"2012","unstructured":"Soca\u0142a K, Nieoczym D, Wyska E, Poleszak E, Wla\u017a P (2012d) Sildenafil, a phosphodiesterase type 5 inhibitor, reduces antidepressant-like activity of paroxetine in the forced swim test in mice. Pharmacol Rep 64:1259\u20131266","journal-title":"Pharmacol Rep"},{"key":"9852_CR33","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1002\/bmc.3459","volume":"29","author":"B Strach","year":"2015","unstructured":"Strach B, Wyska E, Pociecha K, Krupa A, Jachowicz R (2015) Sensitive and precise HPLC method with back-extraction clean-up step for the determination of sildenafil in rat plasma and its application to a pharmacokinetic study. Biomed Chromatogr 29:1559\u20131566","journal-title":"Biomed Chromatogr"},{"key":"9852_CR34","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/gbb.12208","volume":"14","author":"M Sturm","year":"2015","unstructured":"Sturm M, Becker A, Schroeder A, Bilkei-Gorzo A, Zimmer A (2015) Effect of chronic corticosterone application on depression-like behavior in C57BL\/6\u00a0N and C57BL\/6\u00a0J mice. Genes Brain Behav 14:292\u2013300","journal-title":"Genes Brain Behav"},{"key":"9852_CR35","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s00213-005-0302-2","volume":"185","author":"P Tahsili-Fahadan","year":"2006","unstructured":"Tahsili-Fahadan P, Yahyavi-Firouz-Abadi N, Orandi AH, Esmaeili B, Basseda Z, Dehpour AR (2006) Rewarding properties of sildenafil citrate in mice: role of the nitric oxide-cyclic GMP pathway. Psychopharmacology 185:201\u2013207","journal-title":"Psychopharmacology"},{"key":"9852_CR36","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.neuroscience.2014.03.025","volume":"268","author":"VS Tomaz","year":"2014","unstructured":"Tomaz VS, Cordeiro RC, Costa AM, de Lucena DF, Nobre Junior HV, de Sousa FC, Vasconcelos SM, Vale ML, Quevedo J, Macedo D (2014) Antidepressant-like effect of nitric oxide synthase inhibitors and sildenafil against lipopolysaccharide-induced depressive-like behavior in mice. Neuroscience 268:236\u2013246","journal-title":"Neuroscience"},{"key":"9852_CR37","first-page":"150","volume":"59","author":"S Uthayathas","year":"2007","unstructured":"Uthayathas S, Karuppagounder SS, Thrash BM, Parameshwaran K, Suppiramaniam V, Dhanasekaran M (2007) Versatile effects of sildenafil: recent pharmacological applications. Pharmacol Rep 59:150\u2013163","journal-title":"Pharmacol Rep"},{"key":"9852_CR38","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s11011-014-9533-4","volume":"29","author":"C Wang","year":"2014","unstructured":"Wang C, Zhang J, Lu Y, Lin P, Pan T, Zhao X, Liu A, Wang Q, Zhou W, Zhang HT (2014) Antidepressant-like effects of the phosphodiesterase-4 inhibitor etazolate and phosphodiesterase-5 inhibitor sildenafil via cyclic AMP or cyclic GMP signaling in mice. Metab Brain Dis 29:673\u2013682","journal-title":"Metab Brain Dis"},{"key":"9852_CR39","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.euroneuro.2010.07.011","volume":"20","author":"AD Zomkowski","year":"2010","unstructured":"Zomkowski AD, Engel D, Gabilan NH, Rodrigues AL (2010) Involvement of NMDA receptors and l-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effects of escitalopram in the forced swimming test. Eur Neuropsychopharmacol 20:793\u2013801","journal-title":"Eur Neuropsychopharmacol"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-016-9852-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11011-016-9852-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-016-9852-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T21:14:50Z","timestamp":1748985290000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11011-016-9852-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,10]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["9852"],"URL":"https:\/\/doi.org\/10.1007\/s11011-016-9852-8","relation":{},"ISSN":["0885-7490","1573-7365"],"issn-type":[{"value":"0885-7490","type":"print"},{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,10]]}}}