{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T15:55:42Z","timestamp":1768319742195,"version":"3.49.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2016,7,13]],"date-time":"2016-07-13T00:00:00Z","timestamp":1468368000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1007\/s11011-016-9870-6","type":"journal-article","created":{"date-parts":[[2016,7,13]],"date-time":"2016-07-13T00:51:09Z","timestamp":1468371069000},"page":"1419-1426","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Altered urinary porphyrins and mercury exposure as biomarkers for autism severity in Egyptian children with autism spectrum disorder"],"prefix":"10.1007","volume":"31","author":[{"given":"Eman M.","family":"Khaled","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagwa A.","family":"Meguid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2632-3935","authenticated-orcid":false,"given":"Geir","family":"Bj\u00f8rklund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amr","family":"Gouda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed H.","family":"Bahary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adel","family":"Hashish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nermin M.","family":"Sallam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Chirumbolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona A.","family":"El-Bana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,7,13]]},"reference":[{"key":"9870_CR1","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1744-9081-10-14","volume":"10","author":"A Alabdali","year":"2014","unstructured":"Alabdali A, Al-Ayadhi L, El-Ansary A (2014) A key role for an impaired detoxification mechanism in the etiology and severity of autism spectrum disorders. Behav Brain Funct 10:14. doi: 10.1186\/1744-9081-10-14","journal-title":"Behav Brain Funct"},{"key":"9870_CR2","first-page":"27","volume":"64","author":"A Albizzati","year":"2012","unstructured":"Albizzati A, Mor\u00e8 L, Di Candia D, Saccani M, Lenti C (2012) Normal concentrations of heavy metals in autistic spectrum disorders. Minerva Pediatr 64:27\u201331","journal-title":"Minerva Pediatr"},{"key":"9870_CR3","volume-title":"Diagnostic and statistical manual of mental disorders: DSM-IV-TR.","author":"APA - American Psychiatric Association","year":"2000","unstructured":"APA - American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders: DSM-IV-TR. American Psychiatric Association, Washington, DC"},{"key":"9870_CR4","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1080\/15287390802271723","volume":"71","author":"DW Austin","year":"2008","unstructured":"Austin DW, Shandley K (2008) An investigation of porphyrinuria in Australian children with autism. J Toxicol Environ Health A 71:1349\u20131351","journal-title":"J Toxicol Environ Health A"},{"key":"9870_CR5","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.gde.2009.04.004","volume":"19","author":"BR Bill","year":"2009","unstructured":"Bill BR, Geschwind DH (2009) Genetic advances in autism: heterogeneity and convergence on shared pathways. Curr Opin Genet Dev 19:271\u2013278","journal-title":"Curr Opin Genet Dev"},{"key":"9870_CR6","first-page":"948","volume":"111","author":"G Bj\u00f8rklund","year":"1991","unstructured":"Bj\u00f8rklund G (1991) Mercury in the dental office. Risk evaluation of the occupational environment in dental care (in Norwegian). Tidsskr Nor Laegeforen 111:948\u2013951","journal-title":"Tidsskr Nor Laegeforen"},{"key":"9870_CR7","doi-asserted-by":"crossref","first-page":"225","DOI":"10.55782\/ane-2013-1932","volume":"73","author":"G Bj\u00f8rklund","year":"2013","unstructured":"Bj\u00f8rklund G (2013) The role of zinc and copper in autism spectrum disorders. Acta Neurobiol Exp (Wars) 73:225\u2013236","journal-title":"Acta Neurobiol Exp (Wars)"},{"key":"9870_CR8","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1124\/mol.110.069831","volume":"79","author":"T Chernova","year":"2011","unstructured":"Chernova T, Steinert JR, Richards P, Mistry R, Challiss RA, Jukes-Jones R, Cain K, Smith AG, Forsythe ID (2011) Early failure of N-methyl-D-aspartate receptors and deficient spine formation induced by reduction of regulatory heme in neurons. Mol Pharmacol 79:844\u2013854. doi: 10.1124\/mol.110.069831","journal-title":"Mol Pharmacol"},{"key":"9870_CR9","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/bmc.656","volume":"20","author":"M Danton","year":"2006","unstructured":"Danton M, Lim CK (2006) Porphyrin profiles in blood, urine and faeces by HPLC\/electrospray ionization tandem mass spectrometry. Biomed Chromatogr 20:612\u2013621","journal-title":"Biomed Chromatogr"},{"key":"9870_CR10","first-page":"47","volume":"30","author":"TA Deisher","year":"2015","unstructured":"Deisher TA, Doan NV, Koyama K, Bwabye S (2015) Epidemiologic and Molecular Relationship Between Vaccine Manufacture and Autism Spectrum Disorder Prevalence. Issues Law Med 30:47\u201370","journal-title":"Issues Law Med"},{"key":"9870_CR11","doi-asserted-by":"crossref","unstructured":"Dickerson AS, Rahbar MH, Han I, Bakian AV, Bilder DA, Harrington RA, Pettygrove S, Durkin M, Kirby RS, Wingate MS, Tian LH, Zahorodny WM, Pearson DA, Moy\u00e9 LA 3rd, Baio J (2015) Autism spectrum disorder prevalence and proximity to industrial facilities releasing arsenic, lead or mercury. Sci Total Environ 536:245\u2013251.","DOI":"10.1016\/j.scitotenv.2015.07.024"},{"key":"9870_CR12","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s11011-015-9745-2","volume":"31","author":"I Endreffy","year":"2016","unstructured":"Endreffy I, Bj\u00f8rklund G, Dics\u0151 F, Urbina MA, Endreffy E (2016) Acid glycosaminoglycan (aGAG) excretion is increased in children with autism spectrum disorder, and it can be controlled by diet. Metab Brain Dis 31:273\u2013278","journal-title":"Metab Brain Dis"},{"key":"9870_CR13","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1177\/1362361305053255","volume":"9","author":"A Fido","year":"2005","unstructured":"Fido A, Al-Saad S (2005) Toxic trace elements in the hair of children with autism. Autism 9:290\u2013298","journal-title":"Autism"},{"key":"9870_CR14","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/BF03033334","volume":"10","author":"DA Geier","year":"2006","unstructured":"Geier DA, Geier MR (2006) A prospective assessment of porphyrins in autistic disorders: a potential marker for heavy metal exposure. Neurotox Res 10:57\u201364","journal-title":"Neurotox Res"},{"key":"9870_CR15","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1080\/15287390701457712","volume":"70","author":"DA Geier","year":"2007","unstructured":"Geier DA, Geier MR (2007) A prospective study of mercury toxicity biomarkers in autistic spectrum disorders. J Toxicol Environ Health A 70:1723\u20131730","journal-title":"J Toxicol Environ Health A"},{"key":"9870_CR16","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1586\/14737159.8.6.671","volume":"8","author":"DA Geier","year":"2008","unstructured":"Geier DA, Geier MR (2008) Autism spectrum disorder-associated biomarkers for case evaluation and management by clinical geneticists. Expert Rev Mol Diagn 8:671\u2013674","journal-title":"Expert Rev Mol Diagn"},{"key":"9870_CR17","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1080\/15287390903232475","volume":"72","author":"DA Geier","year":"2009","unstructured":"Geier DA, Kern JK, Geier MR (2009a) A prospective blinded evaluation of urinary porphyrins verses the clinical severity of autism spectrum disorders. J Toxicol Environ Health A 72:1585\u20131591","journal-title":"J Toxicol Environ Health A"},{"key":"9870_CR18","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jns.2008.08.021","volume":"280","author":"DA Geier","year":"2009","unstructured":"Geier DA, Kern JK, Garver CR, Adams JB, Audhya T, Nataf R, Geier MR (2009c) Biomarkers of environmental toxicity and susceptibility in autism. J Neurol Sci 280:101\u2013108","journal-title":"J Neurol Sci"},{"key":"9870_CR19","doi-asserted-by":"crossref","first-page":"189","DOI":"10.55782\/ane-2009-1744","volume":"69","author":"DA Geier","year":"2009","unstructured":"Geier DA, Kern JK, Geier MR (2009b) A prospective study of prenatal mercury exposure from maternal dental amalgams and autism severity. Acta Neurobiol Exp (Wars) 69:189\u2013197","journal-title":"Acta Neurobiol Exp (Wars)"},{"key":"9870_CR20","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/ca.22717","volume":"29","author":"F Jumah","year":"2016","unstructured":"Jumah F, Ghannam M, Adeeb N, Tubbs RS (2016) Neuroanatomical variation in autism spectrum disorder: A comprehensive review. Clin Anat 29:454\u2013465","journal-title":"Clin Anat"},{"key":"9870_CR21","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s10534-010-9349-6","volume":"23","author":"JK Kern","year":"2010","unstructured":"Kern JK, Geier DA, Adams JB, Geier MR (2010) A biomarker of mercury body-burden correlated with diagnostic domain specific clinical symptoms of autism spectrum disorder. Biometals 23:1043\u20131051","journal-title":"Biometals"},{"key":"9870_CR22","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1080\/02772248.2010.508609","volume":"93","author":"JK Kern","year":"2011","unstructured":"Kern JK, Geier DA, Ayzac F, Adams JB, Mehta JA, Geier MR (2011a) Toxicity biomarkers among US children compared to a similar cohort in France: a blinded study measuring urinary porphyrins. Toxicol Environ Chem 93:396\u2013405","journal-title":"Toxicol Environ Chem"},{"key":"9870_CR23","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1442-200X.2010.03196.x","volume":"53","author":"JK Kern","year":"2011","unstructured":"Kern JK, Geier DA, Adams JB, Mehta JA, Grannemann BD, Geier MR (2011b) Toxicity biomarkers in autism spectrum disorder: a blinded study of urinary porphyrins. Pediatr Int 53:147\u2013153","journal-title":"Pediatr Int"},{"key":"9870_CR24","first-page":"537","volume":"35","author":"JK Kern","year":"2014","unstructured":"Kern JK, Geier DA, Bj\u00f8rklund G, King PG, Homme KG, Haley BE, Sykes LK, Geier MR (2014) Evidence supporting a link between dental amalgams and chronic illness, fatigue, depression, anxiety, and suicide. Neuro Endocrinol Lett 35:537\u2013552","journal-title":"Neuro Endocrinol Lett"},{"key":"9870_CR25","doi-asserted-by":"publisher","DOI":"10.1007\/s11948-015-9713-6","author":"JK Kern","year":"2015","unstructured":"Kern JK, Geier DA, Deth RC, Sykes LK, Hooker BS, Love JM, Bj\u00f8rklund G, Chaigneau CG, Haley BE, Geier MR (2015) Systematic assessment of research on autism spectrum disorder and mercury reveals conflicts of interest and the need for transparency in autism research. Sci Eng Ethics. doi: 10.1007\/s11948-015-9713-6","journal-title":"Sci Eng Ethics"},{"key":"9870_CR26","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s12011-010-8766-2","volume":"142","author":"MD Lakshmi Priya","year":"2011","unstructured":"Lakshmi Priya MD, Geetha A (2011) Level of trace elements (copper, zinc, magnesium and selenium) and toxic elements (lead and mercury) in the hair and nail of children with autism. Biol Trace Elem Res 142:148\u2013158","journal-title":"Biol Trace Elem Res"},{"key":"9870_CR27","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/brain\/awg014","volume":"126","author":"TI Lidsky","year":"2003","unstructured":"Lidsky TI, Schneider JS (2003) Lead neurotoxicity in children: basic mechanisms and clinical correlates. Brain 126:5\u201319","journal-title":"Brain"},{"key":"9870_CR28","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1093\/ije\/dyt282","volume":"43","author":"K Lyall","year":"2014","unstructured":"Lyall K, Schmidt RJ, Hertz-Picciotto I (2014) Maternal life style and environmental risk factors for autism spectrum disorders. Int J Epidemiol 43:443\u2013464","journal-title":"Int J Epidemiol"},{"key":"9870_CR29","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s12011-014-0121-6","volume":"163","author":"M Macedoni-Luk\u0161i\u010d","year":"2015","unstructured":"Macedoni-Luk\u0161i\u010d M, Gosar D, Bj\u00f8rklund G, Ora\u017eem J, Kodri\u010d J, Le\u0161nik-Musek P, Zupan\u010di\u010d M, France-\u0160tiglic A, Se\u0161ek-Bri\u0161ki A, Neubauer D, Osredkar J (2015) Levels of metals in the blood and specific porphyrins in the urine in children with autism spectrum disorders. Biol Trace Elem Res 163:2\u201310","journal-title":"Biol Trace Elem Res"},{"key":"9870_CR30","first-page":"206","volume":"7","author":"FM Metwally","year":"2015","unstructured":"Metwally FM, Abdelraoof ER, Rashad H, Hasheesh A, Elsedfy ZB, Gebril O, Meguid NA (2015) Toxic effect of some heavy metals in Egyptian autistic children. Int J Pharm Clin Res 7:206\u2013211","journal-title":"Int J Pharm Clin Res"},{"key":"9870_CR31","first-page":"1","volume":"2015","author":"GH Mortazavi","year":"2015","unstructured":"Mortazavi GH, Haghani M, Rastegarian N, Zarei S, Mortazavi SMJ (2015) Increased release of mercury from dental amalgam fillings due to maternal exposure to electromagnetic fields as a possible mechanism for the high rates of autism in the offspring: introducing a hypothesis. J Biomed Phys Eng 2015:1\u20136","journal-title":"J Biomed Phys Eng"},{"key":"9870_CR32","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-015-9784-8","author":"GA Mostafa","year":"2016","unstructured":"Mostafa GA, Bj\u00f8rklund G, Urbina MA, Al-Ayadhi LY (2016a) The levels of blood mercury and inflammatory-related neuropeptides in the serum are correlated in children with autism spectrum disorder. Metab Brain Dis. doi: 10.1007\/s11011-015-9784-8","journal-title":"Metab Brain Dis"},{"key":"9870_CR33","doi-asserted-by":"publisher","unstructured":"Mostafa GA, Bj\u00f8rklund G, Urbina MA, Al-Ayadhi LY (2016b) The positive association between elevated blood lead levels and brain-specific autoantibodies in autistic children from low lead-polluted areas. Metab Brain Dis. doi: 10.1007\/s11011-016-9836-8","DOI":"10.1007\/s11011-016-9836-8"},{"key":"9870_CR34","doi-asserted-by":"publisher","unstructured":"Mutter J (2011) Is dental amalgam safe for humans? The opinion of the scientific committee of the European Commission. J Occup Med Toxicol 6(2). doi: 10.1186\/1745-6673-6-2","DOI":"10.1186\/1745-6673-6-2"},{"key":"9870_CR35","first-page":"439","volume":"26","author":"J Mutter","year":"2005","unstructured":"Mutter J, Naumann J, Schneider R, Walach H, Haley B (2005) Mercury and autism: accelerating evidence? Neuro Endocrinol Lett 26:439\u2013446","journal-title":"Neuro Endocrinol Lett"},{"key":"9870_CR36","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.taap.2006.04.008","volume":"214","author":"R Nataf","year":"2006","unstructured":"Nataf R, Skorupka C, Amet L, Lam A, Springbett A, Lathe R (2006) Porphyrinuria in childhood autistic disorder: implications for environmental toxicity. Toxicol Appl Pharmacol 214:99\u2013108","journal-title":"Toxicol Appl Pharmacol"},{"key":"9870_CR37","unstructured":"Owley T, Leventhal BL, Cook EH (2003) Childhood disorders: The autism spectrum disorders. In: Tasman A, Kay J, Lieberman JA (eds). Psychiatry, 2nd ed. Wiley, Chichester, pp. 757\u2013770"},{"key":"9870_CR38","unstructured":"Pendergrass JC, Haley BE, Vimy MJ, Winfield SA, Lorscheider FL (1997) Mercury vapor inhalation inhibits binding of GTP to tubulin in rat brain: similarity to a molecular lesion in Alzheimer diseased brain. Neurotoxicology 18:315\u2013324"},{"key":"9870_CR39","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.taap.2013.12.011","volume":"274","author":"JP Rooney","year":"2013","unstructured":"Rooney JP (2013) The retention time of inorganic mercury in the brain - a systematic review of the evidence. Toxicol Appl Pharmacol 274:425\u2013435","journal-title":"Toxicol Appl Pharmacol"},{"key":"9870_CR40","doi-asserted-by":"crossref","unstructured":"Rutter M, Le CA, Lord C (2003) Autism Diagnostic Interview-Revised (ADI-R). Western Psychological Services, Los Angeles","DOI":"10.1037\/t18128-000"},{"key":"9870_CR41","unstructured":"Schopler E, Reichler RJ, Rochen-Renner B (1998) The Childhood Autism Rating Scale (CARS). Western Psychological Services, Los Angels"},{"key":"9870_CR42","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.chroma.2007.01.071","volume":"1145","author":"G Stoev","year":"2007","unstructured":"Stoev G, Stoyanov A, Shopova M, Dachev K (2007) Identification of porphyrin modified photosensitizer porfimer sodium and its precursors by high performance liquid chromatography and mass spectrometry. J Chromatogr A 1145:141\u2013148","journal-title":"J Chromatogr A"},{"key":"9870_CR43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trac.2004.08.011","volume":"24","author":"J Wang","year":"2005","unstructured":"Wang J, Hansen HE (2005) Trends and perspectives of flow injection\/ sequential injection on-line sample-pretreatment schemes coupled to ETAAS. Trends Anal Chem 24:1\u20138","journal-title":"Trends Anal Chem"},{"key":"9870_CR44","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3109\/1354750X.2011.598564","volume":"16","author":"L Wang","year":"2011","unstructured":"Wang L, Angley MT, Gerber JP, Sorich MJ (2011) A review of candidate urinary biomarkers for autism spectrum disorder. Biomarkers 16:537\u2013552","journal-title":"Biomarkers"},{"key":"9870_CR45","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1111\/ejn.13028","volume":"42","author":"CT Wong","year":"2015","unstructured":"Wong CT, Wais J, Crawford DA (2015) Prenatal exposure to common environmental factors affects brain lipids and increases risk of developing autism spectrum disorders. Eur J Neurosci 42:2742\u20132760","journal-title":"Eur J Neurosci"},{"key":"9870_CR46","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.taap.2004.12.016","volume":"206","author":"JS Woods","year":"2005","unstructured":"Woods JS, Echeverria D, Heyer NJ, Simmonds PL, Wilkerson J, Farin FM (2005) The association between genetic polymorphisms of coproporphyrinogen oxidase and an atypical porphyrinogenic response to mercury exposure in humans. Toxicol Appl Pharmacol 206:113\u2013120","journal-title":"Toxicol Appl Pharmacol"},{"key":"9870_CR47","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.etap.2014.10.005","volume":"38","author":"HA Yassa","year":"2014","unstructured":"Yassa HA (2014) Autism: a form of lead and mercury toxicity. Environ Toxicol Pharmacol 38:1016\u20131024","journal-title":"Environ Toxicol Pharmacol"},{"key":"9870_CR48","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.neuro.2014.06.007","volume":"44","author":"K Yoshimasu","year":"2014","unstructured":"Yoshimasu K, Kiyohara C, Takemura S, Nakai K (2014) A meta-analysis of the evidence on the impact of prenatal and early infancy exposures to mercury on autism and attention deficit\/hyperactivity disorder in the childhood. Neurotoxicology 44:121\u2013131","journal-title":"Neurotoxicology"},{"key":"9870_CR49","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1080\/15287391003614000","volume":"73","author":"SI Youn","year":"2010","unstructured":"Youn SI, Jin SH, Kim SH, Lim S (2010) Porphyrinuria in Korean children with autism: correlation with oxidative stress. J Toxicol Environ Health A 73:701\u2013710","journal-title":"J Toxicol Environ Health A"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-016-9870-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11011-016-9870-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-016-9870-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-016-9870-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T06:03:13Z","timestamp":1718690593000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11011-016-9870-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,13]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["9870"],"URL":"https:\/\/doi.org\/10.1007\/s11011-016-9870-6","relation":{},"ISSN":["0885-7490","1573-7365"],"issn-type":[{"value":"0885-7490","type":"print"},{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,13]]}}}