{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:30:20Z","timestamp":1788406220675,"version":"build-2803163510"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T00:00:00Z","timestamp":1499385600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1007\/s11011-017-0065-6","type":"journal-article","created":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T16:47:22Z","timestamp":1499446042000},"page":"1785-1790","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Decreased brain serotonin turnover rate following administration of Sharbat-e-Ahmed Shah produces antidepressant and anxiolytic effect in rats"],"prefix":"10.1007","volume":"32","author":[{"given":"Muhammad","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisha","family":"Azmat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,7,7]]},"reference":[{"issue":"1","key":"65_CR1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.4081\/jphia.2010.e7","volume":"1","author":"O Alibrahim","year":"2010","unstructured":"Alibrahim O, Al-Sadat N, Elawad N (2010) Gender and risk of depression in Saudi Arabia, a systematic review and meta-analysis. Journal of Public Health in Africa 1(1):22\u201325","journal-title":"Journal of Public Health in Africa"},{"issue":"1","key":"65_CR2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jtcme.2016.02.003","volume":"7","author":"A Amalraj","year":"2016","unstructured":"Amalraj A, Gopi S (2016) Medicinal properties of Terminalia Arjuna (Roxb.) Wight & Arn.: a review. Journal of Traditional and Complementary Medicine 7(1):65\u201378","journal-title":"Journal of Traditional and Complementary Medicine"},{"issue":"8","key":"65_CR3","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1177\/1403494811424611","volume":"39","author":"I Andersen","year":"2011","unstructured":"Andersen I, Thielen K, Bech P, Nygaard E, Diderichsen F (2011) Increasing prevalence of depression from 2000 to 2006. Scand J Public Health 39(8):857\u2013863","journal-title":"Scand J Public Health"},{"issue":"7","key":"65_CR4","first-page":"30","volume":"3","author":"K Ashwani","year":"2012","unstructured":"Ashwani K, Sapna R, Somiya S, Niketa (2012) Recent review on plant molecular biology, phytophysiology, phytochemictry and Ethonopharmacology of Cuscuta reflexa Roxb. A wonderful parasitic plant. IRJP 3(7):30\u201338","journal-title":"IRJP"},{"key":"65_CR5","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1192\/bjp.179.4.308","volume":"179","author":"JL Ayuso-Mateos","year":"2001","unstructured":"Ayuso-Mateos JL, Vazquez-Barquero JL, Dowrick C, Lehtinen V, Dalgard OS, Casey P, Wilkinson C, Lasa L, Page H, Dunn G, Wilkinson G (2001) ODIN group: depressive disorders in Europe: prevalence figures from the ODIN study. Br J Psychiatry 179:308\u2013316","journal-title":"Br J Psychiatry"},{"issue":"1","key":"65_CR6","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1001\/archgenpsychiatry.2007.11","volume":"65","author":"DA Barton","year":"2008","unstructured":"Barton DA, Esler MD, Dawood T, Lambert EA, Haikerwal D, Brenchley C, Socratous F, Hastings J, Guo L, Wiesner G, Kaye DM, Bayles R, Schlaich MP, Lambert GW (2008) Elevated brain serotonin turnover in patients with depression: effect of genotype and therapy. Arch Gen Psychiatry 65(1):38\u201346","journal-title":"Arch Gen Psychiatry"},{"key":"65_CR7","doi-asserted-by":"crossref","first-page":"334","DOI":"10.3109\/15622975.2013.804195","volume":"14","author":"M Bauer","year":"2013","unstructured":"Bauer M, Pfennig A, Severus E, Whybrow PC, Angst J, M\u00f6ller HJ (2013) On behalf of the task force on unipolar depressive disorders. World Federation of Societies of biological Psychiatry (WFSBP) guidelines for biological treatment of unipolar depressive disorders, part 1: update 2013 on the acute and continuation treatment of unipolar depressive disorders. World J Biol Psychiatry 14:334\u2013385","journal-title":"World J Biol Psychiatry"},{"issue":"2","key":"65_CR8","first-page":"209","volume":"26","author":"DM Benjumea","year":"2016","unstructured":"Benjumea DM, G\u00f3mez-Betancur IC, V\u00e1squez J, Alzate F, Garc\u00eda-Silva A, Fontenla JA (2016) Neuropharmacological effects of the ethanolic extract of Sida acuta. Rev Bras 26(2):209\u2013215","journal-title":"Rev Bras"},{"issue":"1","key":"65_CR9","first-page":"657","volume":"2","author":"SP Borole","year":"2011","unstructured":"Borole SP, Oswal RJ, Antre RV, Kshirsagar SS, Bagul YR (2011) Evaluation of anti-epileptic activity of Cuscuta reflexa Roxb. Res J Pharm Biol and Chem Sci 2(1):657\u2013663","journal-title":"Res J Pharm Biol and Chem Sci"},{"key":"65_CR10","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1590\/S0100-879X2000000200004","volume":"33","author":"JB Calixto","year":"2000","unstructured":"Calixto JB (2000) Efficacy, safety, quality control, marketing and regulatory guidelines for herbal medicines (phytotherapeutic agents). Braz J Med Biol Res 33:179\u2013189","journal-title":"Braz J Med Biol Res"},{"issue":"4","key":"65_CR11","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0163-8343(94)90006-X","volume":"16","author":"JC Coyne","year":"1994","unstructured":"Coyne JC, Fechner-Bates S, Schwenk TL (1994) Prevalence, nature, and comorbidity of depressive disorders in primary care. Gen Hosp Psychiatry 16(4):267\u2013276","journal-title":"Gen Hosp Psychiatry"},{"key":"65_CR12","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0091-3057(80)90067-2","volume":"13","author":"J Crawley","year":"1980","unstructured":"Crawley J, Goodwin FK (1980) Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines. Pharmacol Biochem and Behav 13:167\u2013170","journal-title":"Pharmacol Biochem and Behav"},{"issue":"4","key":"65_CR13","first-page":"764","volume":"2","author":"J Debnath","year":"2010","unstructured":"Debnath J, Sharma UR, Kumar B, Chauhan NS (2010) Anticonvulsant activity of ethanolic extract of fruits of Terminalia chebula on experimental animals. Int J Drug Dev & Res 2(4):764\u2013768","journal-title":"Int J Drug Dev & Res"},{"issue":"1","key":"65_CR14","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2174\/187152707779940835","volume":"6","author":"NA DeMartinis","year":"2007","unstructured":"DeMartinis NA, Winokur A (2007) Effects of psychiatric medications on sleep and sleep disorders. CNS Neurol Disord Drug Targets 6(1):17\u201329","journal-title":"CNS Neurol Disord Drug Targets"},{"issue":"4","key":"65_CR15","first-page":"353","volume":"4","author":"M Eerike","year":"2013","unstructured":"Eerike M, Uma Maheswari N (2013) Antidepressant activity of Ethanolic extract of Nymphaea alba flower in albino mice. Int J Pharm Bio Sci 4(4):353\u2013357","journal-title":"Int J Pharm Bio Sci"},{"key":"65_CR16","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.physbeh.2014.05.032","volume":"135","author":"A Ennaceur","year":"2013","unstructured":"Ennaceur A (2013) Tests of unconditioned anxiety \u2014 pitfalls and disappointments. Physiol and Behav 135:55\u201371","journal-title":"Physiol and Behav"},{"issue":"12","key":"65_CR17","doi-asserted-by":"crossref","first-page":"6","DOI":"10.5812\/ircmj.17511","volume":"16","author":"Z Feyzabadi","year":"2014","unstructured":"Feyzabadi Z, Jafari F, Kamali SH, Ashayeri H, Aval SB, Esfahani MM, Sadeghpour O (2014) Efficacy of Viola odorata in treatment of chronic insomnia. Iran Red Crescent Med J 16(12):6","journal-title":"Iran Red Crescent Med J"},{"issue":"2","key":"65_CR18","first-page":"3","volume":"8","author":"S Flamerzi","year":"2010","unstructured":"Flamerzi S, Al-Emadi N, Kuwari MGA, Ghanim IM, Ahmad A (2010) Prevalence and determinants of depression among primary health care attendees in Qatar 2008. Middle East Journal of Family Medicine 8(2):3\u20137","journal-title":"Middle East Journal of Family Medicine"},{"issue":"2","key":"65_CR19","volume":"2","author":"AAM Gadit","year":"2007","unstructured":"Gadit AAM, Mugford G (2007) Prevalence of depression among households in three capital cities of Pakistan: need to revise the mental health policy. PLoS One 2(2):e209","journal-title":"PLoS One"},{"key":"65_CR20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0165-0327(98)00053-6","volume":"50","author":"A Ghadirian","year":"1998","unstructured":"Ghadirian A, Murphy BEP, Gendron MJ (1998) Efficacy of light versus tryptophan therapy in seasonal affective. J Affect Disord 50:23\u201327","journal-title":"J Affect Disord"},{"key":"65_CR21","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0378-8741(99)00198-1","volume":"71","author":"AH Gilani","year":"2000","unstructured":"Gilani AH, Aziz N, Khan MA, Shaheen F, Jabeen Q, Siddiqui BS (2000) Ethnopharmacological evaluation of the anticonvulsant, sedative and antispasmodic activities of Lavandula stoechas L. J Ethnopharmacol 71:161\u2013167","journal-title":"J Ethnopharmacol"},{"issue":"7","key":"65_CR22","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0165-6147(03)00164-0","volume":"24","author":"A Gorji","year":"2003","unstructured":"Gorji A (2003) Pharmacological treatment of headache using traditional persian medicine. Trends Pharmacol Sci 24(7):331\u2013334","journal-title":"Trends Pharmacol Sci"},{"key":"65_CR23","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1097\/00001756-199409080-00025","volume":"5","author":"DJ Haleem","year":"1994","unstructured":"Haleem DJ, Parveen T (1994) Brain regional serotonin synthesis following adaptation to repeated restraint. Neuroreport 5:1785\u20131788","journal-title":"Neuroreport"},{"key":"65_CR24","first-page":"9","volume":"11","author":"DJ Haleem","year":"1998","unstructured":"Haleem DJ, Haider S, Yasmeen A, Perveen T (1998) The neurochemical profile of long term oral administration of moclobemide. Pak J Pharm Sci 11:9\u201314","journal-title":"Pak J Pharm Sci"},{"issue":"1601","key":"65_CR25","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1098\/rstb.2012.0109","volume":"367","author":"JPR Jacobsen","year":"2012","unstructured":"Jacobsen JPR, Medvedev IO, Caron MG (2012) The 5-HT deficiency theory of depression: perspectives from a naturalistic 5-HT deficiency model, the tryptophan hydroxylase 2Arg439His knockin mouse. Philos Trans R Soc B: Biol Sci 367(1601):2444\u20132459","journal-title":"Philos Trans R Soc B: Biol Sci"},{"issue":"6","key":"65_CR26","first-page":"295","volume":"3","author":"M Ledochowski","year":"1998","unstructured":"Ledochowski M, Sperner-Unterweger B, Widner B, Fuchs D (1998) Fructose malabsorption is associated with early signs of mental depression. Eur J Med Res 3(6):295\u2013298","journal-title":"Eur J Med Res"},{"issue":"4","key":"65_CR27","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1080\/003655201300051135","volume":"36","author":"M Ledochowski","year":"2001","unstructured":"Ledochowski M, Widner B, Murr C, Sperner-Unterweger B, Fuchs D (2001) Fructose malabsorption is associated with decreased plasma tryptophan. Scand J Gastroenterol 36(4):367\u2013371","journal-title":"Scand J Gastroenterol"},{"key":"65_CR28","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/sj.npp.1300406","volume":"29","author":"F Lopez-Rodriguez","year":"2004","unstructured":"Lopez-Rodriguez F, Kim J, Poland RE (2004) Total sleep deprivation decreases immobility in the forced-swim test. Neuropsycho Phamacolo 29:1105\u20131111","journal-title":"Neuropsycho Phamacolo"},{"issue":"2","key":"65_CR29","first-page":"68","volume":"21","author":"FK Luni","year":"2009","unstructured":"Luni FK, Ansari B, Jawad A, Dawson A, Baig SM (2009) Prevalence of depression and anxiety in a village in Sindh. J Ayub Med Coll Abbottabad 21(2):68\u201372","journal-title":"J Ayub Med Coll Abbottabad"},{"key":"65_CR30","first-page":"556","volume":"27","author":"A Mannan","year":"1989","unstructured":"Mannan A, Khan RA, Asif M (1989) Pharmacodynamic studies on Polypodium vulgare (Linn.) Ind J Exp Bio 27:556\u2013560","journal-title":"Ind J Exp Bio"},{"issue":"7","key":"65_CR31","first-page":"125","volume":"2","author":"A Monadi","year":"2013","unstructured":"Monadi A, Rezaie A (2013) Evaluation of sedative and pre-anesthetic effects of Viola odorata Linn. Extract compared with diazepam in rats. Bull Env Pharmacol Life Sci 2(7):125\u2013131","journal-title":"Bull Env Pharmacol Life Sci"},{"key":"65_CR32","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1104\/pp.75.1.138","volume":"75","author":"TM Murphy","year":"1984","unstructured":"Murphy TM (1984) Effect of sulfhydryl reagents on K+ efflux from rose cells relationship to ultraviolet-stimulated efflux. Plant Physiol 75:138\u2013141","journal-title":"Plant Physiol"},{"key":"65_CR33","unstructured":"National Institute of Health Guidelines for Care and Use of Laboratory Animals in Biomedical Research (2010) Guide for the Care and Use of Laboratory Animals. Prepublication draft, 8th edn. The national Academies Press, Washington, D.C., p 6:47"},{"issue":"2s","key":"65_CR34","first-page":"S112","volume":"40","author":"M Pahuja","year":"2008","unstructured":"Pahuja M, Mehla J, Reeta KH, Tripathi VK, Gupta YK (2008) Screening of selected Indian plants for their antiepileptic potential in PTZ and MES induced seizures in rats. Indian J Pharmacol 40(2s):S112\u2013S142","journal-title":"Indian J Pharmacol"},{"issue":"1","key":"65_CR35","first-page":"20","volume":"45","author":"T Perveen","year":"2012","unstructured":"Perveen T, Haider S, Nudrat AZ, Ahmed W, Zehra BZ, Begum S (2012) Effect of herbal combination on biochemical and behavioral responses in rats. Pak J Biochem Mol Biol 45(1):20\u201322","journal-title":"Pak J Biochem Mol Biol"},{"key":"65_CR36","first-page":"327","volume":"229","author":"RD Porsolt","year":"1977","unstructured":"Porsolt RD, Bertin A, Jalfre M (1977) Behavioral despair in mice: a primary screening test for antidepressants. Arch Int de Pharmacodyn et de Therapie 229:327\u2013336","journal-title":"Arch Int de Pharmacodyn et de Therapie"},{"key":"65_CR37","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0014-2999(03)01272-X","volume":"463","author":"L Prut","year":"2003","unstructured":"Prut L, Belzung C (2003) The open field as a paradigm measure the effect of drugs on anxiety-like behaviours: a review. Eur J Pharmacol 463:3\u201333","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"65_CR38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/0253-7176.70510","volume":"32","author":"MS Reddy","year":"2010","unstructured":"Reddy MS (2010) Depression: the disorder and the burden. Indian J Psychol Med 32(1):1\u20132","journal-title":"Indian J Psychol Med"},{"issue":"1","key":"65_CR39","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1590\/S0100-879X1999000100015","volume":"32","author":"MB Ruarte","year":"1999","unstructured":"Ruarte MB, Alvarez EO (1999) Behavioral profiles displayed by rats in an elevated asymmetric plus-maze: effects of diazepam. Braz J Med Biol Res 32(1):99\u2013106","journal-title":"Braz J Med Biol Res"},{"key":"65_CR40","doi-asserted-by":"crossref","first-page":"185","DOI":"10.4103\/0257-7941.107354","volume":"31","author":"S Sarahroodi","year":"2012","unstructured":"Sarahroodi S, Esmaeili S, Mikaili P, Hemmati Z, Saberi Y (2012) The effects of green Ocimum basilicum hydroalcoholic extract on retention and retrieval of memory in mice. Ancient Sci 31:185\u2013189","journal-title":"Ancient Sci"},{"issue":"4","key":"65_CR41","first-page":"295","volume":"14","author":"MN Shafei","year":"2011","unstructured":"Shafei MN, Saberi Z, Amini S (2011) Pharmacological effects of Rosa Damascena. Iran J Basic Med Sci 14(4):295\u2013307","journal-title":"Iran J Basic Med Sci"},{"key":"65_CR42","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0079-6123(08)62153-6","volume":"122","author":"DS Sobel","year":"2000","unstructured":"Sobel DS (2000) Chapter 28: the cost-effectiveness of mind-body medicine interventions. In Mayer, E.A.; Saper, C.B. Prog Brain Res 122:393\u2013412","journal-title":"Prog Brain Res"},{"issue":"10","key":"65_CR43","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1007\/s00018-007-6530-3","volume":"64","author":"D Stenberg","year":"2007","unstructured":"Stenberg D (2007) Neuroanatomy and neurochemistry of sleep. Cell Mol Life Sci 64(10):1187\u20131204","journal-title":"Cell Mol Life Sci"},{"key":"65_CR44","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/chromsci\/46.2.169","volume":"46","author":"K Tekes","year":"2008","unstructured":"Tekes K (2008) HPLC determination of serotonin and its metabolites from human platelet-rich plasma; shift to 5-Hydroxytryptophol formation following alcohol consumption. J Chromatogr Sci 46:167\u2013173","journal-title":"J Chromatogr Sci"},{"issue":"12","key":"65_CR45","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.4088\/JCP.v67n1205","volume":"67","author":"N Vakili","year":"2006","unstructured":"Vakili N, Gorji A (2006) Psychiatry and psychology in medieval Persia. J Clin Psychiatry 67(12):1862\u20131869","journal-title":"J Clin Psychiatry"},{"issue":"7","key":"65_CR46","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/mp.2011.9","volume":"16","author":"EL Donkelaar Van","year":"2011","unstructured":"Van Donkelaar EL, Blokland A, Ferrington L, Steinbusch HW, Prickaerts J (2011) Mechanism of acute tryptophan depletion: is it only serotonin? Mol Psychiatry 16(7):695\u2013713","journal-title":"Mol Psychiatry"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11011-017-0065-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-017-0065-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-017-0065-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,11,11]],"date-time":"2017-11-11T03:10:48Z","timestamp":1510369848000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11011-017-0065-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,7]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["65"],"URL":"https:\/\/doi.org\/10.1007\/s11011-017-0065-6","relation":{},"ISSN":["0885-7490","1573-7365"],"issn-type":[{"value":"0885-7490","type":"print"},{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,7]]}}}