{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:46:01Z","timestamp":1790858761608,"version":"4.1.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T00:00:00Z","timestamp":1501718400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1007\/s11011-017-0073-6","type":"journal-article","created":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T06:34:16Z","timestamp":1501742056000},"page":"1889-1900","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Asparagine Synthetase deficiency-report of a novel mutation and review of literature"],"prefix":"10.1007","volume":"32","author":[{"given":"Neerja","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal Vishnu","family":"Tewari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitika","family":"Langeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallavi","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Punit","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vedam","family":"Ramprasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakthivel","family":"Murugan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reema","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manisha","family":"Jana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhulika","family":"Kabra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,3]]},"reference":[{"key":"73_CR1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/8904_2014_405","volume":"22","author":"M Alfadhel","year":"2015","unstructured":"Alfadhel M, Alrifai MT, Trujillano D, Alshaalan H, Al Othaim A, Al Rasheed S, Assiri H, Alqahtani AA, Alaamery M, Rolfs A, Eyaid W (2015) Asparagine Synthetase deficiency: new inborn errors of metabolism. JIMD Rep 22:11\u201316","journal-title":"JIMD Rep"},{"key":"73_CR2","doi-asserted-by":"crossref","unstructured":"Back SA, Plawner LL (2012) Congenital malformations of the central nervous system. In: Gleason CA, Devaskar SU (ed) Avery\u2019s diseases of the newborn, 9th edn. Philadelphia, pp 864\u2013866","DOI":"10.1016\/B978-1-4377-0134-0.10060-5"},{"key":"73_CR3","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1002\/jcc.20292","volume":"26","author":"JL Banks","year":"2005","unstructured":"Banks JL, Beard HS, Cao Y, Cho AE, Damm W, Farid R, Felts AK, Halgren TA, Mainz DT, Maple JR, Murphy R, Philipp DM, Repasky MP, Zhang LY, Berne BJ, Friesner RA, Gallicchio E, Levy RM (2005) Integrated modeling program, applied chemical theory (IMPACT). J Comput Chem 26:1752\u20131780","journal-title":"J Comput Chem"},{"issue":"10","key":"73_CR4","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1111\/dmcn.13141","volume":"58","author":"C Barba","year":"2016","unstructured":"Barba C, Darra F, Cusmai R, Procopio E, Dionisi Vici C, Keldermans L, Vuillaumier-Barrot S, Lefeber DJ, Guerrini R, CDG Group (2016) Congenital disorders of glycosylation presenting as epileptic encephalopathy with migrating partial seizures in infancy. Dev Med Child Neurol 58(10):1085\u20131091","journal-title":"Dev Med Child Neurol"},{"issue":"3","key":"73_CR5","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s11011-014-9618-0","volume":"30","author":"S Ben-Salem","year":"2015","unstructured":"Ben-Salem S, Gleeson JG, Al-Shamsi AM, Islam B, Hertecant J, Ali BR, Al-Gazali L (2015) Asparagine synthetase deficiency detected by whole exome sequencing causes congenital microcephaly, epileptic encephalopathy and psychomotor delay. Metab Brain Dis 30(3):687\u2013694","journal-title":"Metab Brain Dis"},{"key":"73_CR6","doi-asserted-by":"crossref","unstructured":"Bowers KJ, Edmond Chow, Huafeng Xu, Ron O. Dror, Michael P. Eastwood, Brent A. Gregersen, John L. Klepeis, Istvan Kolossvary, Mark A. Moraes, Federico D. Sacerdoti, John K. Salmon, Yibing Shan, David E. Shaw (2006) Scalable Algorithms for Molecular Dynamics Simulations on Commodity Clusters. Proceedings of the 2006 ACM\/IEEE Conference on Supercomputing (SC06)","DOI":"10.1109\/SC.2006.54"},{"issue":"5","key":"73_CR7","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1136\/jmedgenet-2014-102952","volume":"52","author":"JM Capo-Chichi","year":"2015","unstructured":"Capo-Chichi JM, Boissel S, Brustein E, Pickles S, Fallet-Bianco C, Nassif C, Patry L, Dobrzeniecka S, Liao M, Labuda D, Samuels ME, Hamdan FF, VandeVelde C, Rouleau GA, Drapeau P, Michaud JL (2015) Disruption of CLPB is associated with congenital microcephaly, severe encephalopathy and 3-methylglutaconic aciduria. J Med Genet 52(5):303\u2013311","journal-title":"J Med Genet"},{"key":"73_CR8","doi-asserted-by":"crossref","unstructured":"Cederbaum S, Berry GT (2012) Inborn errors of carbohydrate, ammonia, amino acid and organic acid metabolism. In: Gleason CA, Devaskar SU (ed) Avery\u2019s diseases of the newborn, 9th edn. Philadelphia, pp 215\u2013257","DOI":"10.1016\/B978-1-4377-0134-0.10022-8"},{"key":"73_CR9","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.pediatrneurol.2014.10.028","volume":"52","author":"P Curatolo","year":"2015","unstructured":"Curatolo P (2015) Mechanistic target of rapamycin (mTOR) in tuberous sclerosis complex associated epilepsy. Pediatr Neurol 52:281\u2013289","journal-title":"Pediatr Neurol"},{"key":"73_CR10","volume-title":"Molecular modeling program package","author":"Discovery Studio 2.0","year":"2006","unstructured":"Discovery Studio 2.0 (2006) Molecular modeling program package. Accelrys Software Inc, San Diego"},{"key":"73_CR11","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/S0076-6879(97)77022-8","volume":"277","author":"D Eisenberg","year":"1997","unstructured":"Eisenberg D, Luthy R, Bowie JU (1997) VERIFY3D: assessment of protein models with three-dimensional profiles. Methods Enzymol 277:396\u2013404","journal-title":"Methods Enzymol"},{"issue":"3","key":"73_CR12","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s10545-016-9921-5","volume":"39","author":"AW El-Hattab","year":"2016","unstructured":"El-Hattab AW, Shaheen R, Hertecant J, Galadari HI, Albaqawi BS, Nabil A, Alkuraya FS (2016) On the phenotypic spectrum of serine biosynthesis defects. J Inherit Metab Dis 39(3):373\u2013381","journal-title":"J Inherit Metab Dis"},{"key":"73_CR13","doi-asserted-by":"crossref","first-page":"D514","DOI":"10.1093\/nar\/gki033","volume":"33","author":"A Hamosh","year":"2005","unstructured":"Hamosh A et al (2005) Online Mendelian inheritance in man (OMIM), a knowledgebase of human genes and genetic disorders. Nucleic Acids Res 33:D514\u2013D517","journal-title":"Nucleic Acids Res"},{"key":"73_CR14","doi-asserted-by":"crossref","unstructured":"Hawkins RA, O\u2019Kane RL, Simpson IA, Vina JR (2006) Structure of the blood\u2013brain barrier and its role in the transport of amino acids. J Nutr 136(1 Suppl):218S-226S","DOI":"10.1093\/jn\/136.1.218S"},{"key":"73_CR15","unstructured":"Kinsman SL, Johnston MV (2016) Congenital anomalies of the central nervous system. In: Kliegman RM, Behrman RE, Stanton BF, St Geme JW, Schor NF (ed) Nelson textbook of pediatrics, 20th, edn. Philadelphia, pp 2802\u20132817"},{"key":"73_CR16","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1002\/ajmg.a.31757","volume":"143A","author":"DA Kline","year":"2007","unstructured":"Kline DA, Krantz ID, Sommer A, Kliewer M, Jackson LG et al (2007) Cornelia de Lange syndrome: clinical review, diagnostic and scoring systems, and anticipatory guidance. Am J Med Genet A 143A:1287\u20131296","journal-title":"Am J Med Genet A"},{"issue":"10","key":"73_CR17","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1586\/ern.11.135","volume":"11","author":"A Kohlschutter","year":"2011","unstructured":"Kohlschutter A, Eichler F (2011) Childhood leukodystrophies: a clinical perspective. Expert Rev Neurother 11(10):1485\u20131496","journal-title":"Expert Rev Neurother"},{"issue":"D1","key":"73_CR18","doi-asserted-by":"crossref","first-page":"D862","DOI":"10.1093\/nar\/gkv1222","volume":"44","author":"MJ Landrum","year":"2015","unstructured":"Landrum MJ et al (2015) ClinVar: public archive of interpretations of clinically relevant variants. Nucleic Acids Res 44(D1):D862\u2013D868","journal-title":"Nucleic Acids Res"},{"key":"73_CR19","doi-asserted-by":"crossref","first-page":"16146","DOI":"10.1021\/bi9915768","volume":"38","author":"TM Larsen","year":"1999","unstructured":"Larsen TM, Boehlein SK, Schuster SM, Richards NG, Thoden JB, Holden HM, Rayment I (1999) Three-dimensional structure of Escherichia Coli asparagine synthetase B: a short journey from substrate to product. Biochemistry 38:16146\u201316157","journal-title":"Biochemistry"},{"key":"73_CR20","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","volume":"26","author":"RA Laskowski","year":"1993","unstructured":"Laskowski RA, MacArthur MW, Moss DS, Thornton JM (1993) PROCHECK: a program to check the steriochemical quality of protein structures. J Appl Crystallogr 26:283\u2013291","journal-title":"J Appl Crystallogr"},{"key":"73_CR21","doi-asserted-by":"crossref","unstructured":"Lek M et al (2016) Analysis of Protein-Coding Genetic Variation in 60,706 Humans. Nature 536.7616:285\u2013291","DOI":"10.1038\/nature19057"},{"issue":"5","key":"73_CR22","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/bioinformatics\/btp698","volume":"26","author":"H Li","year":"2010","unstructured":"Li H, Durbin R (2010) Fast and accurate long-read alignment with burrows-wheeler transform. Bioinformatics 26(5):589\u2013595","journal-title":"Bioinformatics"},{"issue":"16","key":"73_CR23","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","volume":"25","author":"H Li","year":"2009","unstructured":"Li H et al (2009) The sequence alignment\/map format and SAM tools. Bioinformatics (Oxford, England) 25(16):2078\u20132079","journal-title":"Bioinformatics (Oxford, England)"},{"issue":"9","key":"73_CR24","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1101\/gr.107524.110","volume":"20","author":"A McKenna","year":"2010","unstructured":"McKenna A et al (2010) The genome analysis toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res 20(9):1297\u20131303","journal-title":"Genome Res"},{"issue":"16","key":"73_CR25","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1093\/bioinformatics\/btq330","volume":"26","author":"W McLaren","year":"2010","unstructured":"McLaren W et al (2010) Deriving the consequences of genomic variants with the Ensembl API and SNP effect predictor. Bioinformatics 26(16):2069\u20132070","journal-title":"Bioinformatics"},{"key":"73_CR26","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1136\/jmg.25.11.750","volume":"25","author":"P Merlob","year":"1988","unstructured":"Merlob P, Steier D, Reisner SH (1988) Autosomal dominant isolated (\u2018uncomplicated\u2019) microcephaly. J Med Genet 25:750\u2013753","journal-title":"J Med Genet"},{"issue":"D1","key":"73_CR27","doi-asserted-by":"crossref","first-page":"D64","DOI":"10.1093\/nar\/gks1048","volume":"41","author":"LR Meyer","year":"2012","unstructured":"Meyer LR et al (2012) The UCSC genome browser database: extensions and updates 2013. Nucleic Acids Res 41(D1):D64\u2013D69","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"73_CR28","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1093\/bioinformatics\/btq028","volume":"26","author":"A Mottaz","year":"2010","unstructured":"Mottaz A et al (2010) Easy retrieval of single amino-acid polymorphisms and phenotype information using SwissVar. Bioinformatics 26(6):851\u2013852","journal-title":"Bioinformatics"},{"key":"73_CR29","doi-asserted-by":"crossref","unstructured":"Nagasaki M, Yasuda J, Katsuoka F, Nariai N, Kojima K, Kawai Y, Yamaguchi-Kabata Y, Yokozawa J, Danjoh I, Saito S, Sato Y, Mimori T, Tsuda K, Saito R, Pan X, Nishikawa S, Ito S, Kuroki Y, Tanabe O, Fuse N, Kuriyama S, Kiyomoto H, Hozawa A, Minegishi N, Engel JD, Kinoshita K, Kure S, Yaegashi N, Tsuboi A, Nagami F, Kawame H, Tomita H, Tsuji I, Nakaya J, Sugawara J, Suzuki K, Kikuya M, Abe M, Nakaya N, Osumi N, Yamashita R, Ogishima S, Takai T, Tominaga T, Taki Y, Suzuki Y, Yamamoto M (2015) Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals. Nat Commun 6:8018","DOI":"10.1038\/ncomms9018"},{"issue":"3","key":"73_CR30","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ymgme.2015.08.007","volume":"116","author":"EE Palmer","year":"2015","unstructured":"Palmer EE, Hayner J, Sachdev R, Cardamone M, Kandula T, Morris P, Dias KR, Tao J, Miller D, Zhu Y, Macintosh R, Dinger ME, Cowley MJ, Buckley MF, Roscioli T, Bye A, Kilberg MS, Kirk EP (2015) Asparagine Synthetase deficiency causes reduced proliferation of cells under conditions of limited asparagine. Mol Genet Metab 116(3):178\u2013186","journal-title":"Mol Genet Metab"},{"key":"73_CR31","unstructured":"Rezvani I, Rezvani GA (2016) Metabolic disorders. In: Kliegman RM, Behrman RE, Stanton BF, St Geme JW, Schor NF (ed) Nelson textbook of pediatrics, 20th edn. Philadelphia, pp 634\u2013736"},{"issue":"2","key":"73_CR32","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.neuron.2013.08.013","volume":"80","author":"EK Ruzzo","year":"2013","unstructured":"Ruzzo EK, Capo-Chichi JM, Ben-Zeev B, Chitayat D, Mao H, Pappas AL, Hitomi Y, Lu YF, Yao X, Hamdan FF, Pelak K, Reznik-Wolf H, Bar-Joseph I, Oz-Levi D, Lev D, Lerman-Sagie T, Leshinsky-Silver E, Anikster Y, Ben-Asher E, Olender T, Colleaux L, D\u00e9carie JC, Blaser S, Banwell B, Joshi RB, He XP, Patry L, Silver RJ, Dobrzeniecka S, Islam MS, Hasnat A, Samuels ME, Aryal DK, Rodriguiz RM, Jiang Y, Wetsel WC, McNamara JO, Rouleau GA, Silver DL, Lancet D, Pras E, Mitchell GA, Michaud JL, Goldstein DB (2013) Deficiency of asparagine synthetase causes congenital microcephaly and a progressive form of encephalopathy. Neuron 80(2):429\u2013441","journal-title":"Neuron"},{"key":"73_CR33","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1006\/jmbi.1993.1626","volume":"234","author":"A Sali","year":"1993","unstructured":"Sali A, Blundell TL (1993) Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol 234:779\u2013815","journal-title":"J Mol Biol"},{"key":"73_CR34","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s12883-016-0633-0","volume":"16","author":"MZ Seidahmed","year":"2016","unstructured":"Seidahmed MZ, Salih MA, Abdulbasit OB, Samadi A, Al Hussien K, Miqdad AM, Biary MS, Alazami AM, Alorainy IA, Kabiraj MM, Shaheen R, Alkuraya FS (2016) Hyperekplexia, microcephaly and simplified gyral pattern caused by novel ASNS mutations, case report. BMC Neurol 16:105. doi: 10.1186\/s12883-016-0633-0","journal-title":"BMC Neurol"},{"key":"73_CR35","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/ng.526","volume":"42","author":"J Shen","year":"2010","unstructured":"Shen J, Gilmore EC, Marshall CA, Haddadin M, Reynolds JJ, Eyaid W, Bodell A, Barry B, Gleason D, Allen K, Ganesh VS, Chang BS, Grix A, Hill RS, Topcu M, Caldecott KW, Barkovich AJ, Walsh CA (2010) Mutations in PNKP cause microcephaly, seizures and defects in DNA repair. (letter). Nat Genet 42:245\u2013249","journal-title":"Nat Genet"},{"issue":"6","key":"73_CR36","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/humu.10212","volume":"21","author":"PD Stenson","year":"2003","unstructured":"Stenson PD et al (2003) Human gene mutation database (HGMD): 2003 update. Hum Mutat 21(6):577\u2013581","journal-title":"Hum Mutat"},{"key":"73_CR37","doi-asserted-by":"publisher","unstructured":"Sun J, McGillivray AJ, Pinner J, Yan Z, Liu F, Bratkovic D, Thompson E, Wei X, Jiang H, Asan, Chopra M (2016). Diaphragmatic Eventration in sisters with asparagine Synthetase deficiency: a novel homozygous ASNS mutation and expanded phenotype. JIMD Rep\u00a0\u200b34:1-9.\u00a0\u200bdoi: 10.1007\/8904_2016_3","DOI":"10.1007\/8904_2016_3"},{"key":"73_CR38","unstructured":"Sutton VR, Van den Veyver IB, Aicardi Syndrome (2006) In: Pagon RA, Adam MP, Ardinger HH et al (eds) GeneReviews\u00ae [internet]. Seattle (WA): University of Washington, Seattle; 1993\u20132017. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1381\/"},{"issue":"7571","key":"73_CR39","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature15393","volume":"526","author":"The 1000 Genomes Project Consortium","year":"2015","unstructured":"The 1000 Genomes Project Consortium (2015) A global reference for human genetic variation. Nature 526(7571):68\u201374","journal-title":"Nature"},{"key":"73_CR40","doi-asserted-by":"publisher","unstructured":"Verity C, Firth H, and Constant CF (2003) Congenital abnormalities of the central nervous system. J NeurolNeurosurg Psychiatry 74(Suppl I):i3-i8. doi: 10.1136\/jnnp.74.suppl_1.i3","DOI":"10.1136\/jnnp.74.suppl_1.i3"},{"key":"73_CR41","unstructured":"Verloes A, Drunat S, Gressens P et al (2009) Primary autosomal recessive Microcephalies and Seckel syndrome Spectrum disorders. In: Pagon RA, Adam MP, Ardinger HH et al (eds) GeneReviews\u00ae [Internet]. University of Washington, Seattle; 1993\u20132017 Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK9587\/"},{"issue":"D1","key":"73_CR42","doi-asserted-by":"crossref","first-page":"D1001","DOI":"10.1093\/nar\/gkt1229","volume":"42","author":"D Welter","year":"2013","unstructured":"Welter D et al (2013) The NHGRI GWAS catalog, a curated resource of SNP-trait associations. Nucleic Acids Res 42(D1):D1001\u2013D1006","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"73_CR43","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.braindev.2016.09.010","volume":"39","author":"T Yamamoto","year":"2016","unstructured":"Yamamoto T, Endo W, Ohnishi H, Kubota K, Kawamoto N, Inui T, Imamura A, Takanashi JI, Shiina M, Saitsu H, Ogata K, Matsumoto N, Haginoya K, Fukao T (2016) The first report of Japanese patients with asparagine synthetase deficiency. Brain Dev 39(3):236\u2013242. doi: 10.1016\/j.braindev.2016.09.010","journal-title":"Brain Dev"}],"updated-by":[{"DOI":"10.1007\/s11011-017-0102-5","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T00:00:00Z","timestamp":1504569600000}}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11011-017-0073-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-017-0073-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-017-0073-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T00:11:22Z","timestamp":1569975082000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11011-017-0073-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,3]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["73"],"URL":"https:\/\/doi.org\/10.1007\/s11011-017-0073-6","relation":{"erratum":[{"id-type":"doi","id":"10.1007\/s11011-017-0102-5","asserted-by":"object"}]},"ISSN":["0885-7490","1573-7365"],"issn-type":[{"value":"0885-7490","type":"print"},{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,3]]}}}