{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T18:59:13Z","timestamp":1777143553017,"version":"3.51.4"},"reference-count":123,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,1,6]],"date-time":"2018-01-06T00:00:00Z","timestamp":1515196800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"National Natural Science Foundation of China (CN)","award":["81302852"],"award-info":[{"award-number":["81302852"]}]},{"name":"National Natural Science Foundation of China (CN)","award":["81541028"],"award-info":[{"award-number":["81541028"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1007\/s11011-017-0178-y","type":"journal-article","created":{"date-parts":[[2018,1,6]],"date-time":"2018-01-06T20:38:43Z","timestamp":1515271123000},"page":"647-660","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["The role of tryptophan metabolism in postpartum depression"],"prefix":"10.1007","volume":"33","author":[{"given":"Kai-Ming","family":"Duan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Hui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sai-Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZhengDong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YingYong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HeYa","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,1,6]]},"reference":[{"issue":"9","key":"178_CR1","first-page":"1203","volume":"42","author":"N Adachi","year":"1990","unstructured":"Adachi N, Ogasawara T, Nishijima M (1990) Tryptophan etabolism during the perinatal period. Nihon Sanka Fujinka Gakkai Zasshi 42(9):1203\u20131210","journal-title":"Nihon Sanka Fujinka Gakkai Zasshi"},{"issue":"4","key":"178_CR2","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00737-013-0349-8","volume":"16","author":"A Alvim-Soares","year":"2013","unstructured":"Alvim-Soares A, Miranda D, Campos SB, Figueira P, Romano-Silva MA, Correa H (2013) Postpartum depression symptoms associated with val158met comt polymorphism. Arch Womens Ment Health 16(4):339\u2013340","journal-title":"Arch Womens Ment Health"},{"key":"178_CR3","doi-asserted-by":"crossref","unstructured":"Anderson, G (2018) Linking the biological underpinnings of depression: Role of mitochondria interactions with melatonin, inflammation, sirtuins, tryptophan catabolites, DNA repair and oxidative and nitrosative stress, with consequences for classification and cognition. Prog Neuropsychopharmacol Biol Psychiatry 80(Pt C):255\u2013266","DOI":"10.1016\/j.pnpbp.2017.04.022"},{"key":"178_CR4","doi-asserted-by":"crossref","unstructured":"Anderson G, Maes M (2017a) How Immune-inflammatory processes link CNS and psychiatric disorders: Classification and Treatment Implications. CNS Neurol Disord Drug Targets 16(3):266\u2013278","DOI":"10.2174\/1871527315666161122144659"},{"key":"178_CR5","doi-asserted-by":"crossref","first-page":"117864691769173","DOI":"10.1177\/1178646917691738","volume":"10","author":"G Anderson","year":"2017","unstructured":"Anderson G, Maes M (2017b) Interactions of Tryptophan and Its Catabolites With Melatonin and the Alpha 7 Nicotinic Receptor in Central Nervous System and Psychiatric Disorders: Role of the Aryl Hydrocarbon Receptor and Direct Mitochondria Regulation. Int J Tryptophan Res 10:1178646917691738","journal-title":"Int J Tryptophan Res"},{"issue":"23","key":"178_CR6","doi-asserted-by":"crossref","first-page":"3812","DOI":"10.2174\/13816128113196660738","volume":"20","author":"G Anderson","year":"2014","unstructured":"Anderson G, Maes M (2014) Oxidative\/nitrosative stress and immuno-inflammatory pathways in depression: treatment implications. Curr Pharm Des 20(23):3812\u20133847","journal-title":"Curr Pharm Des"},{"issue":"2","key":"178_CR7","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/acps.12182","volume":"29","author":"G Anderson","year":"2014","unstructured":"Anderson G, Berk M, Maes M (2014) Biological phenotypes underpin the physio-somatic symptoms of somatization, depression, and chronic fatigue syndrome. Acta Psychiatr Scand 29(2):83\u201397","journal-title":"Acta Psychiatr Scand"},{"issue":"9","key":"178_CR8","doi-asserted-by":"crossref","first-page":"277","DOI":"10.2147\/NDT.S25320","volume":"9","author":"G Anderson","year":"2013","unstructured":"Anderson G, Maes M (2013) Postpartum depression: psychoneuroimmunological underpinnings and treatment. Neuropsychiatr Dis Treat 9(9):277\u2013287","journal-title":"Neuropsychiatr Dis Treat"},{"issue":"8","key":"178_CR9","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1080\/00016340600697652","volume":"85","author":"L Andersson","year":"2006","unstructured":"Andersson L, Sundstr\u00f6m-Poromaa I, Wulff M, \u00c5str\u00f6m M, Bixo M (2006) Depression and anxiety during pregnancy and six months postpartum: a follow-up study. Acta Obstet Gynecol Scand 85(8):937\u2013944","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"7354","key":"178_CR10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nature10130","volume":"475","author":"AE Autry","year":"2011","unstructured":"Autry AE, Adachi M, Nosyreva E, Na ES, Los MF, Cheng PF et al (2011) Nmda receptor blockade at rest triggers rapid behavioural antidepressant responses. Nature 475(7354):91\u201395","journal-title":"Nature"},{"issue":"5","key":"178_CR11","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20150197","volume":"35","author":"AA Badawy","year":"2015","unstructured":"Badawy AA (2015) Tryptophan metabolism, disposition and utilization in pregnancy. Biosci Rep 35(5):e00261","journal-title":"Biosci Rep"},{"issue":"4","key":"178_CR12","doi-asserted-by":"crossref","first-page":"249","DOI":"10.5468\/ogs.2014.57.4.249","volume":"57","author":"AA Badawy","year":"2014","unstructured":"Badawy AA (2014) The tryptophan utilization concept in pregnancy. Obstet Gynecol Sci 57(4):249\u2013259","journal-title":"Obstet Gynecol Sci"},{"issue":"1","key":"178_CR13","first-page":"369","volume":"255","author":"AA Badawy","year":"1988","unstructured":"Badawy AA (1988) Effects of pregnancy on tryptophan metabolism and disposition in the rat. Biochem J 255(1):369\u2013372","journal-title":"Biochem J"},{"issue":"3","key":"178_CR14","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.psyneuen.2005.10.001","volume":"31","author":"KM Ba\u00eflara","year":"2006","unstructured":"Ba\u00eflara KM, Henry C, Lestage J, Launay JM, Parrot F, Swendsen J et al (2006) Decreased brain tryptophan availability as a partial determinant of post-partum blues. Psychoneuroendocrinology 31(3):407\u2013413","journal-title":"Psychoneuroendocrinology"},{"issue":"2","key":"178_CR15","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0098-2997(83)90005-5","volume":"6","author":"DA Bender","year":"1983","unstructured":"Bender DA (1983) Biochemistry of tryptophan in health and disease. Mol Asp Med 6(2):101\u2013197","journal-title":"Mol Asp Med"},{"issue":"2","key":"178_CR16","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.yfrne.2009.04.003","volume":"30","author":"CL Bethea","year":"2009","unstructured":"Bethea CL, Reddy AP, Tokuyama Y, Henderson JA, Lima FB (2009) Protective actions of ovarian hormones in the serotonin system of macaques. Front Neuroendocrinol 30(2):212\u2013238","journal-title":"Front Neuroendocrinol"},{"issue":"1\u20132","key":"178_CR17","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jad.2008.07.008","volume":"115","author":"F Boufidou","year":"2009","unstructured":"Boufidou F, Lambrinoudaki I, Argeitis J, Zervas IM, Pliatsika P, Leonardou AA et al (2009) Csf and plasma cytokines at delivery and postpartum mood disturbances. J Affect Disord 115(1\u20132):287\u2013292","journal-title":"J Affect Disord"},{"issue":"2\u20133","key":"178_CR18","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.psychres.2015.03.031","volume":"227","author":"KAL Bradley","year":"2015","unstructured":"Bradley KAL, Case JAC, Khan O, Ricart T, Hanna A, Alonso CM et al (2015) The role of the kynurenine pathway in suicidality in adolescent major depressive disorder. Psychiatry Res 227(2\u20133):206\u2013212","journal-title":"Psychiatry Res"},{"issue":"2","key":"178_CR19","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0306-4522(00)00277-3","volume":"100","author":"A Catalani","year":"2000","unstructured":"Catalani A, Casolini P, Scaccianoce S, Patacchioli FR, Spinozzi P, Angelucci L (2000) Maternal corticosterone during lactation permanently affects brain corticosteroid receptors, stress response and behaviour in rat progeny. Neuroscience 100(2):319\u2013325","journal-title":"Neuroscience"},{"issue":"4","key":"178_CR20","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1517\/14728222.2011.553603","volume":"15","author":"K Chopra","year":"2011","unstructured":"Chopra K, Kumar B, Kuhad A (2011) Pathobiological targets of depression. Expert Opin Ther Targets 15(4):379\u2013400","journal-title":"Expert Opin Ther Targets"},{"issue":"93","key":"178_CR21","first-page":"1294","volume":"2009","author":"M Craig","year":"2009","unstructured":"Craig M, Howard LM (2009) Postnatal depression. Clin Evid 2009(93):1294\u20131296","journal-title":"Clin Evid"},{"issue":"3","key":"178_CR22","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.psychres.2011.03.012","volume":"188","author":"S Claes","year":"2011","unstructured":"Claes S, Myint AM, Domschke K, Del-Favero J, Entrich K, Engelborghs S et al (2011) The kynurenine pathway in major depression: haplotype analysis of three related functional candidate genes. Psychiatry Res 188(3):355\u2013360","journal-title":"Psychiatry Res"},{"issue":"8","key":"178_CR23","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.pt.2012.05.008","volume":"28","author":"V Combes","year":"2012","unstructured":"Combes V, Guillemin GJ, Chan-Ling T, Hunt NH, Grau GER (2012) The crossroads of neuroinflammation in infectious diseases: endothelial cells and astrocytes. Trends Parasitol 28(8):311\u2013319","journal-title":"Trends Parasitol"},{"key":"178_CR24","doi-asserted-by":"crossref","unstructured":"Connor TJ, Starr N, O'Sullivan JB, Harkin A (2008) Induction of indolamine 2,3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: a role for ifn-\u03b3?. Neurosci Lett 441(1):29\u201334","DOI":"10.1016\/j.neulet.2008.06.007"},{"key":"178_CR25","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1192\/bjp.111.470.105","volume":"111","author":"A Coppen","year":"1965","unstructured":"Coppen A, Shaw DM, Malleson A (1965) Changes in 5-hydroxytryptophan metabolism in depression. Br J Psychiatry 111:105\u2013107","journal-title":"Br J Psychiatry"},{"issue":"3","key":"178_CR26","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1177\/0269881111434622","volume":"26","author":"JA Cutler","year":"2012","unstructured":"Cutler JA, Rush AJ, Mcmahon FJ, Laje G (2012) Common genetic variation in the indoleamine-2,3-dioxygenase genes and antidepressant treatment outcome in major depressive disorder. J Psychopharmacol 26(3):360\u2013367","journal-title":"J Psychopharmacol"},{"issue":"7","key":"178_CR27","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.pnpbp.2009.07.013","volume":"33","author":"B Doornbos","year":"2009","unstructured":"Doornbos B, Dijck-Brouwer DAJ, Kema IP, Tanke MAC, Goor SAV, Muskiet FAJ et al (2009) The development of peripartum depressive symptoms is associated with gene polymorphisms of maoa, 5-htt and comt. Prog Neuro-Psychopharmacol Biol Psychiatry 33(7):1250\u20131254","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"issue":"9\u201310","key":"178_CR28","first-page":"15","volume":"10","author":"SY El-Ibiary","year":"2013","unstructured":"El-Ibiary SY, Hamilton SP, Abel R, Erdman CA, Robertson PA, Finley PR (2013) A pilot study evaluating genetic and environmental factors for postpartum depression. Innov Clin Neurosci 10(9\u201310):15\u201322","journal-title":"Innov Clin Neurosci"},{"issue":"1","key":"178_CR29","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1017\/S0033291798007685","volume":"29","author":"MA Ellenbogen","year":"1999","unstructured":"Ellenbogen MA, Young SN, Dean P, Palmour RM, Benkelfat C (1999) Acute tryptophan depletion in healthy young women with a family history of major affective disorder. Psychol Med 29(1):35\u201346","journal-title":"Psychol Med"},{"issue":"1","key":"178_CR30","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1080\/01612840802498268","volume":"30","author":"I Engqvist","year":"2009","unstructured":"Engqvist I, Ferszt G, \u00c5hlin A, Nilsson K (2009) Psychiatric nurses' descriptions of women with postpartum psychosis and nurses' responses\u2014an exploratory study in sweden. Issues Ment Health Nurs 30(1):23\u201330","journal-title":"Issues Ment Health Nurs"},{"issue":"5","key":"178_CR31","doi-asserted-by":"crossref","first-page":"e425","DOI":"10.1542\/peds.112.5.e425","volume":"112","author":"CN Epperson","year":"2003","unstructured":"Epperson CN, Jatlow PI, Czarkowski K, Anderson GM (2003) Maternal fluoxetine treatment in the postpartum period: effects on platelet serotonin and plasma drug levels in breastfeeding mother-infant pairs. Pediatrics 112(5):e425\u2013e425","journal-title":"Pediatrics"},{"key":"178_CR32","unstructured":"Erhardt S, Schwieler L, Imbeault S, Engberg G (2016) The kynurenine pathway in schizophrenia and bipolar disorder. Neuropharmacology 112(Pt B):297\u2013306"},{"issue":"4","key":"178_CR33","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1177\/0890334416662241","volume":"32","author":"V Fallon","year":"2016","unstructured":"Fallon V, Groves R, Halford JC, Bennett KM, Harrold JA (2016) Postpartum anxiety and infant-feeding outcomes. J Hum Lact 32(4):740\u2013758","journal-title":"J Hum Lact"},{"key":"178_CR34","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jad.2014.10.016","volume":"172","author":"FP Figueiredo","year":"2015","unstructured":"Figueiredo FP, Parada AP, Araujo LFD, Silva WA Jr, Del-Ben CM (2015) The influence of genetic factors on peripartum depression: a systematic review. J Affect Disord 172:265\u2013273","journal-title":"J Affect Disord"},{"key":"178_CR35","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jad.2016.04.002","volume":"200","author":"X Gao","year":"2016","unstructured":"Gao X, Jing W, Hong Y, Yan C, Cheng R (2016) Serum bdnf concentration after delivery is associated with development of postpartum depression: a 3-month follow up study. J Affect Disord 200:25\u201330","journal-title":"J Affect Disord"},{"issue":"5","key":"178_CR36","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1192\/bjp.148.5.567","volume":"148","author":"PR Gard","year":"1986","unstructured":"Gard PR, Handley SL, Parsons AD, Waldron G (1986) A multivariate investigation of postpartum mood disturbance. Br J Psychiatry J Ment Sci 148(5):567\u2013575","journal-title":"Br J Psychiatry J Ment Sci"},{"issue":"119","key":"178_CR37","first-page":"1","volume":"119","author":"BN Gaynes","year":"2005","unstructured":"Gaynes BN, Gavin N, Meltzerbrody S, Lohr KN, Swinson T, Gartlehner G et al (2005) Perinatal depression: prevalence, screening accuracy, and screening outcomes. Evid Rep Technol Assess 119(119):1\u20138","journal-title":"Evid Rep Technol Assess"},{"issue":"6","key":"178_CR38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1461145713001673","volume":"17","author":"SM Gibney","year":"2014","unstructured":"Gibney SM, Fagan EM, Waldron AM, O'Byrne J, Connor TJ, Harkin A (2014) Inhibition of stress-induced hepatic tryptophan 2,3-dioxygenase exhibits antidepressant activity in an animal model of depressive behaviour. Int J Neuropsychopharmacol 17(6):1\u201312","journal-title":"Int J Neuropsychopharmacol"},{"issue":"3","key":"178_CR39","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.bbi.2012.11.010","volume":"28","author":"SM Gibney","year":"2013","unstructured":"Gibney SM, Mcguinness B, Prendergast C, Harkin A, Connor TJ (2013) Poly i:c-induced activation of the immune response is accompanied by depression and anxiety-like behaviours, kynurenine pathway activation and reduced bdnf expression. Brain Behav Immun 28(3):170\u2013181","journal-title":"Brain Behav Immun"},{"issue":"8","key":"178_CR40","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.bbi.2010.06.015","volume":"24","author":"LC Gleeson","year":"2010","unstructured":"Gleeson LC, Ryan KJ, Griffin \u00c9W, Connor TJ, Harkin A (2010) The \u03b2 2 -adrenoceptor agonist clenbuterol elicits neuroprotective, anti-inflammatory and neurotrophic actions in the kainic acid model of excitotoxicity. Brain Behav Immun 24(8):1354\u20131361","journal-title":"Brain Behav Immun"},{"issue":"1","key":"178_CR41","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1124\/pr.110.003053","volume":"64","author":"SM Goebel-Goody","year":"2012","unstructured":"Goebel-Goody SM, Baum M, Paspalas CD, Fernandez SM, Carty NC, Kurup P et al (2012) Therapeutic implications for striatal-enriched protein tyrosine phosphatase (step) in neuropsychiatric disorders. Pharmacol Rev 64(1):65\u201387","journal-title":"Pharmacol Rev"},{"issue":"24","key":"178_CR42","doi-asserted-by":"crossref","first-page":"7266","DOI":"10.1021\/bi992997s","volume":"39","author":"LE Goldstein","year":"2000","unstructured":"Goldstein LE, Leopold MC, Huang X, Atwood CS, Saunders AJ, Hartshorn M et al (2000) 3-hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction. Biochemistry 39(24):7266\u20137275","journal-title":"Biochemistry"},{"issue":"3","key":"178_CR43","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00018-009-0166-4","volume":"67","author":"Q Han","year":"2010","unstructured":"Han Q, Cai T, Tagle DA, Li J (2010) Han q, cai t, tagle da, li j. structure, expression, and function of kynurenine aminotransferases in human and rodent brains. cell mol life sci 67: 353-368. Cell Mol Life Sci 67(3):353\u2013368","journal-title":"Cell Mol Life Sci"},{"issue":"6078","key":"178_CR44","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1136\/bmj.2.6078.18","volume":"2","author":"SL Handley","year":"1977","unstructured":"Handley SL, Dunn TL, Baker JM, Cockshott C, Gould S (1977) Mood changes in puerperium, and plasma tryptophan and cortisol concentrations. Br Med J 2(6078):18\u201320","journal-title":"Br Med J"},{"issue":"4","key":"178_CR45","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/BF01252130","volume":"49","author":"T Hedner","year":"1980","unstructured":"Hedner T, Lundborg P (1980) Serotoninergic development in the postnatal rat brain. J Neural Transm 49(4):257\u2013279","journal-title":"J Neural Transm"},{"issue":"8","key":"178_CR46","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.1073\/pnas.0912531107","volume":"107","author":"SW Jang","year":"2010","unstructured":"Jang SW, Liu X, Pradoldej S, Tosini G, Chang Q, Iuvone PM et al (2010) N-acetylserotonin activates TrkB receptor in a circadian rhythm. Proc Natl Acad Sci U S A 107(8):3876\u20133881","journal-title":"Proc Natl Acad Sci U S A"},{"key":"178_CR47","doi-asserted-by":"crossref","unstructured":"Jo WK, Zhang Y, Emrich HM, Dietrich DE (2015) Glia in the cytokine-mediated onset of depression: fine tuning the immune response. Front Cell Neurosci 9(8):268","DOI":"10.3389\/fncel.2015.00268"},{"issue":"2","key":"178_CR48","first-page":"223","volume":"99","author":"A Josefsson","year":"2002","unstructured":"Josefsson A, Angelsi\u00f6\u00f6 L, Berg G, Ekstr\u00f6m CM, Gunnervik C, Nordin C et al (2002) Obstetric, somatic, and demographic risk factors for postpartum depressive symptoms. Obstet Gynecol 99(2):223\u2013228","journal-title":"Obstet Gynecol"},{"issue":"3","key":"178_CR49","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1034\/j.1600-0412.2001.080003251.x","volume":"80","author":"A Josefsson","year":"2001","unstructured":"Josefsson A, Berg G, Nordin C, Sydsj\u00f6 G (2001) Prevalence of depressive symptoms in late pregnancy and postpartum. Acta Obstet Gynecol Scand 80(3):251\u2013255","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"Suppl 2","key":"178_CR50","first-page":"5","volume":"7","author":"LIJ Jr","year":"1992","unstructured":"Jr LIJ (1992) Serotonin and psychiatric disorders. Int Clin Psychopharmacol 7(Suppl 2):5\u201311","journal-title":"Int Clin Psychopharmacol"},{"issue":"2","key":"178_CR51","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.euroneuro.2006.02.006","volume":"17","author":"V Kaura","year":"2007","unstructured":"Kaura V, Ingram CD, Gartside SE, Young AH, Judge SJ (2007) The progesterone metabolite allopregnanolone potentiates gaba a, receptor-mediated inhibition of 5-ht neuronal activity. Eur Neuropsychopharmacol 17(2):108\u2013115","journal-title":"Eur Neuropsychopharmacol"},{"issue":"9","key":"178_CR52","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1517\/14656566.2014.911842","volume":"15","author":"DR Kim","year":"2014","unstructured":"Kim DR, Epperson CN, Weiss AR, Wisner KL (2014) Pharmacotherapy of postpartum depression: an update. Expert Opin Pharmacother 15(9):1223\u20131234","journal-title":"Expert Opin Pharmacother"},{"issue":"2\u20133","key":"178_CR53","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jad.2004.12.013","volume":"86","author":"C Kohl","year":"2005","unstructured":"Kohl C, Walch T, Huber R, Kemmler G, Neurauter G, Fuchs D et al (2005) Measurement of tryptophan, kynurenine and neopterin in women with and without postpartum blues. J Affect Disord 86(2\u20133):135\u2013142","journal-title":"J Affect Disord"},{"issue":"15","key":"178_CR54","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.2174\/092986711795656108","volume":"18","author":"S Lancellotti","year":"2011","unstructured":"Lancellotti S, Novarese L, De CR (2011) Biochemical properties of indoleamine 2,3-dioxygenase: from structure to optimized design of inhibitors. Curr Med Chem 18(15):2205\u20132214","journal-title":"Curr Med Chem"},{"issue":"1","key":"178_CR55","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.bbr.2010.02.014","volume":"210","author":"A Laugeray","year":"2010","unstructured":"Laugeray A, Launay JM, Callebert J, Surget A, Belzung C, Barone PR (2010) Peripheral and cerebral metabolic abnormalities of the tryptophan\u2013kynurenine pathway in a murine model of major depression. Behav Brain Res 210(1):84\u201391","journal-title":"Behav Brain Res"},{"issue":"7","key":"178_CR56","doi-asserted-by":"crossref","first-page":"e66996","DOI":"10.1371\/journal.pone.0066996","volume":"8","author":"H Lee","year":"2013","unstructured":"Lee H, Ohno M, Ohta S, Mikami T (2013) Regular moderate or intense exercise prevents depression-like behavior without change of hippocampal tryptophan content in chronically tryptophan-deficient and stressed mice. PLoS One 8(7):e66996","journal-title":"PLoS One"},{"issue":"9","key":"178_CR57","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1016\/j.jada.2009.06.368","volume":"109","author":"BM Leung","year":"2009","unstructured":"Leung BM, Kaplan BJ (2009) Perinatal depression: prevalence, risks, and the nutrition link--a review of the literature. J Am Diet Assoc 109(9):1566\u20131575","journal-title":"J Am Diet Assoc"},{"issue":"1","key":"178_CR58","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1742-1241.1974.tb09108.x","volume":"28","author":"DO Lewis","year":"1974","unstructured":"Lewis DO (1974) The pharmacodynamics of depression and its relation to therapy. Br J Clin Pract 28(1):21\u201327","journal-title":"Br J Clin Pract"},{"issue":"23","key":"178_CR59","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1177\/019394590102300603","volume":"23","author":"MC Logsdon","year":"2001","unstructured":"Logsdon MC, Usui W (2001) Psychosocial predictors of postpartum depression in diverse groups of women. West J Nurs Res 23(23):563\u2013574","journal-title":"West J Nurs Res"},{"issue":"3","key":"178_CR60","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.psyneuen.2005.09.003","volume":"31","author":"M Lommatzsch","year":"2006","unstructured":"Lommatzsch M, Hornych K, Zingler C, Schuff-Werner P, H\u00f6ppner J, Virchow JC (2006) Maternal serum concentrations of bdnf and depression in the perinatal period. Psychoneuroendocrinology 31(3):388\u2013394","journal-title":"Psychoneuroendocrinology"},{"key":"178_CR61","doi-asserted-by":"crossref","unstructured":"Lovelace MD, Varney B, Sundaram G, Lennon MJ, Chai KL, Jacobs K, et al (2017) Recent evidence for an expanded role of the kynurenine pathway of tryptophan metabolism in neurological diseases. Neuropharmacology 112(Pt B):373\u2013388","DOI":"10.1016\/j.neuropharm.2016.03.024"},{"issue":"1\u20133","key":"178_CR62","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/BF01345273","volume":"14","author":"J Luthman","year":"1998","unstructured":"Luthman J, Rades\u00e4ter AC, Oberg C (1998) Effects of the 3-hydroxyanthranilic acid analogue ncr-631 on anoxia-, il-1 beta- and lps-induced hippocampal pyramidal cell loss in vitro. Amino Acids 14(1\u20133):263\u2013269","journal-title":"Amino Acids"},{"issue":"6","key":"178_CR63","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s00737-009-0088-z","volume":"12","author":"YMJ Lin","year":"2009","unstructured":"Lin YMJ, Ko HC, Chang FM, Yeh TL, Sun HS (2009) Population-specific functional variant of the tph2 gene 2755c>a polymorphism contributes risk association to major depression and anxiety in chinese peripartum women. Arch Womens Ment Health 12(6):401\u2013408","journal-title":"Arch Womens Ment Health"},{"key":"178_CR64","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.semcdb.2015.03.002","volume":"40","author":"DC Maddison","year":"2015","unstructured":"Maddison DC, Giorgini F (2015) The kynurenine pathway and neurodegenerative disease. Semin Cell Dev Biol 40:134\u2013141","journal-title":"Semin Cell Dev Biol"},{"key":"178_CR65","doi-asserted-by":"crossref","unstructured":"Maes M, Verkerk R, Bonaccorso S, Ombelet W, Bosmans E, Scharp\u00e9 S (2002) Depressive and anxiety symptoms in the early puerperium are related to increased degradation of tryptophan into kynurenine, a phenomenon which is related to immune activation. Life Sci 71(16):1837","DOI":"10.1016\/S0024-3205(02)01853-2"},{"issue":"5","key":"178_CR66","first-page":"854","volume":"125","author":"PK Mallikarjun","year":"2005","unstructured":"Mallikarjun PK, Oyebode F (2005) Prevention of postnatal depression. J R Soc Promot Heal 125(5):854","journal-title":"J R Soc Promot Heal"},{"issue":"4","key":"178_CR67","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s00737-010-0162-6","volume":"13","author":"R Mann","year":"2010","unstructured":"Mann R, Gilbody S, Adamson J (2010) Prevalence and incidence of postnatal depression: what can systematic reviews tell us? Arch Womens Ment Health 13(4):295\u2013305","journal-title":"Arch Womens Ment Health"},{"issue":"6","key":"178_CR68","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1001\/jama.287.6.762","volume":"287","author":"LJ Miller","year":"2002","unstructured":"Miller LJ (2002) Postpartum depression. JAMA 287(6):762\u2013765","journal-title":"JAMA"},{"issue":"3","key":"178_CR69","doi-asserted-by":"crossref","first-page":"e03581","DOI":"10.7554\/eLife.03581","volume":"3","author":"OH Miller","year":"2014","unstructured":"Miller OH, Yang L, Wang CC, Hargroder EA, Zhang Y, Delpire E et al (2014) Glun2b-containing nmda receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine. Elife Sci 3(3):e03581","journal-title":"Elife Sci"},{"issue":"3","key":"178_CR70","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.jocn.2013.08.020","volume":"21","author":"X Mo","year":"2013","unstructured":"Mo X, Pi L, Yang J, Xiang Z, Tang A (2013) Serum indoleamine 2,3-dioxygenase and kynurenine aminotransferase enzyme activity in patients with ischemic stroke. J Clin Neurosci 21(3):482\u2013486","journal-title":"J Clin Neurosci"},{"issue":"3","key":"178_CR71","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.fertnstert.2007.03.059","volume":"89","author":"EL Moses-Kolko","year":"2008","unstructured":"Moses-Kolko EL, Wisner KL, Price JC, Berga SL, Drevets WC, Hanusa BH et al (2008) Serotonin 1a receptor reductions in postpartum depression: a positron emission tomography study. Fertil Steril 89(3):685\u2013692","journal-title":"Fertil Steril"},{"issue":"21","key":"178_CR72","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1159\/000356540","volume":"21","author":"N M\u00fcller","year":"2014","unstructured":"M\u00fcller N (2014) Immunology of major depression. Neuroimmunomodulation 21(21):123\u2013130","journal-title":"Neuroimmunomodulation"},{"issue":"1433","key":"178_CR73","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.pnpbp.2013.08.008","volume":"48","author":"AM Myint","year":"2014","unstructured":"Myint AM, Kim YK (2014) Network beyond ido in psychiatric disorders: revisiting neurodegeneration hypothesis. Prog Neuro-Psychopharmacol Biol Psychiatry 48(1433):304\u2013313","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"178_CR74","doi-asserted-by":"crossref","unstructured":"Myint AM, Schwarz MJ, M\u00fcller N (2012) The role of the kynurenine metabolism in major depression. J Neural Transm 119(2):245\u2013251","DOI":"10.1007\/s00702-011-0741-3"},{"issue":"20","key":"178_CR75","doi-asserted-by":"crossref","first-page":"8189","DOI":"10.1073\/pnas.1014129108","volume":"108","author":"C Mitchell","year":"2011","unstructured":"Mitchell C, Notterman D, Brooks-Gunn J, Hobcraft J, Garfinkel I, Jaeger K et al (2011) Role of mother's genes and environment in postpartum depression. Proc Natl Acad Sci 108(20):8189\u20138193","journal-title":"Proc Natl Acad Sci"},{"issue":"3","key":"178_CR76","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2174\/1567202054368326","volume":"2","author":"H N\u00e9meth","year":"2005","unstructured":"N\u00e9meth H, Toldi J, V\u00e9csei L (2005) Role of kynurenines in the central and peripheral nervous systems. Curr Neurovasc Res 2(3):249\u2013260","journal-title":"Curr Neurovasc Res"},{"issue":"5","key":"178_CR77","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.jpsychires.2004.01.011","volume":"38","author":"JD Newport","year":"2004","unstructured":"Newport JD, Owens MJ, Knight DL et al (2004) Alterations in platelet serotonin transporter binding in women with postpartum onset major depression. J Psychiatr Res 38(5):467\u2013473","journal-title":"J Psychiatr Res"},{"issue":"7","key":"178_CR78","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1039\/C5FO00407A","volume":"6","author":"AB Nongonierma","year":"2015","unstructured":"Nongonierma AB, Fitzgerald RJ (2015) Milk proteins as a source of tryptophan-containing bioactive peptides. Food Funct 6(7):2115\u20132127","journal-title":"Food Funct"},{"issue":"9","key":"178_CR79","doi-asserted-by":"crossref","first-page":"906","DOI":"10.4088\/JCP.13r08908","volume":"75","author":"S Ogawa","year":"2014","unstructured":"Ogawa S, Fujii T, Koga N, Hori H, Teraishi T, Hattori K, Noda T, Higuchi T, Motohashi N, Kunugi H (2014) Plasma l-tryptophan concentration in major depressive disorder: new data and meta-analysis. J Clin Psychiatry 75(9):906\u2013915","journal-title":"J Clin Psychiatry"},{"issue":"4","key":"178_CR80","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1590\/S0100-879X2008000400012","volume":"41","author":"RM Oliveira","year":"2008","unstructured":"Oliveira RM, Guimar\u00e3es FS, Deakin JF (2008) Expression of neuronal nitric oxide synthase in the hippocampal formation in affective disorders. Braz J Med Biol Res 41(4):333\u2013341","journal-title":"Braz J Med Biol Res"},{"key":"178_CR81","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bbr.2014.07.027","volume":"277","author":"SM O\u2019Mahony","year":"2015","unstructured":"O\u2019Mahony SM, Clarke G, Borre YE, Dinan TG, Cryan JF (2015) Serotonin, tryptophan metabolism and the brain-gut-microbiome axis. Behav Brain Res 277:32\u201348","journal-title":"Behav Brain Res"},{"issue":"4","key":"178_CR82","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1111\/j.1471-4159.2008.05241.x","volume":"105","author":"R Owe-Young","year":"2008","unstructured":"Owe-Young R, Webster NL, Mukhtar M, Pomerantz RJ, Smythe G, Walker D et al (2008) Kynurenine pathway metabolism in human blood\u2013brain\u2013barrier cells: implications for immune tolerance & neurotoxicity. J Neurochem 105(4):1346\u20131357","journal-title":"J Neurochem"},{"issue":"5","key":"178_CR83","doi-asserted-by":"crossref","first-page":"514","DOI":"10.2174\/1389450111314050002","volume":"14","author":"G Oxenkrug","year":"2013","unstructured":"Oxenkrug G (2013) Serotonin \u2013 kynurenine hypothesis of depression: historical overview and recent developments. Curr Drug Targets 14(5):514\u2013521","journal-title":"Curr Drug Targets"},{"issue":"1","key":"178_CR84","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00702-010-0475-7","volume":"118","author":"GF Oxenkrug","year":"2011","unstructured":"Oxenkrug GF (2011) Interferon-gamma-inducible kynurenines\/pteridines inflammation cascade: implications for aging and aging-associated psychiatric and medical disorders. J Neural Transm 118(1):75\u201385","journal-title":"J Neural Transm"},{"issue":"1","key":"178_CR85","first-page":"56","volume":"47","author":"GF Oxenkrug","year":"2010","unstructured":"Oxenkrug GF (2010) Tryptophan kynurenine metabolism as a common mediator of genetic and environmental impacts in major depressive disorder: the serotonin hypothesis revisited 40 years later. Isr J Psychiatry Relat Sci 47(1):56\u201363","journal-title":"Isr J Psychiatry Relat Sci"},{"issue":"1","key":"178_CR86","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1196\/annals.1403.003","volume":"1122","author":"GF Oxenkrug","year":"2007","unstructured":"Oxenkrug GF (2007) Genetic and hormonal regulation of tryptophan\u2013kynurenine metabolism. Ann N Y Acad Sci 1122(1):35\u201349","journal-title":"Ann N Y Acad Sci"},{"key":"178_CR87","first-page":"116","volume":"6","author":"JM Parrott","year":"2014","unstructured":"Parrott JM, O\u2019Connor JC (2014) Kynurenine 3-monooxygenase: an influential mediator of neuropathology. Front Psych 6:116","journal-title":"Front Psych"},{"issue":"5","key":"178_CR88","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/S0027-9684(15)31300-6","volume":"100","author":"K Paul","year":"2008","unstructured":"Paul K, Boutain D, Agnew K, Thomas J, Hitti J (2008) The relationship between racial identity, income, stress and c-reactive protein among parous women: implications for preterm birth disparity research. J Natl Med Assoc 100(5):540\u2013546","journal-title":"J Natl Med Assoc"},{"key":"178_CR89","doi-asserted-by":"crossref","unstructured":"Qin X, Liu JY, Wang T, Pashley DH, Al-Hashim AH, Abdelsayed R, et al (2017) Role of indoleamine 2,3-dioxygenase in an inflammatory model of murine gingiva. J Periodontal Res 52(1):107\u2013113","DOI":"10.1111\/jre.12374"},{"issue":"5","key":"178_CR90","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.psyneuen.2014.03.013","volume":"45","author":"J Quak","year":"2014","unstructured":"Quak J, Doornbos B, Roest AM, Duivis HE, Vogelzangs N, Nolen WA et al (2014) Does tryptophan degradation along the kynurenine pathway mediate the association between pro-inflammatory immune activity and depressive symptoms? Psychoneuroendocrinology 45(5):202\u2013210","journal-title":"Psychoneuroendocrinology"},{"issue":"2","key":"178_CR91","first-page":"125","volume":"5","author":"VDM Rc","year":"2000","unstructured":"Rc VDM, Fekkes D (2000) Serotonin and amino acids: partners in delirium pathophysiology? Semin Clin Neuropsychiatry 5(2):125\u2013131","journal-title":"Semin Clin Neuropsychiatry"},{"issue":"4","key":"178_CR92","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1007\/s12035-016-9877-3","volume":"54","author":"C Roomruangwong","year":"2017","unstructured":"Roomruangwong C, Kanchanatawan B, Sirivichayakul S, Anderson G, Carvalho AF, Duleu S et al (2017) Iga\/igm responses to tryptophan and tryptophan catabolites (trycats) are differently associated with prenatal depression, physio-somatic symptoms at the end of term and premenstrual syndrome. Mol Neurobiol 54(4):3038\u20133049","journal-title":"Mol Neurobiol"},{"issue":"45","key":"178_CR93","doi-asserted-by":"crossref","first-page":"19502","DOI":"10.1073\/pnas.1008178107","volume":"107","author":"A Roth","year":"2010","unstructured":"Roth A, Griffin DE (2010) Hypoxia abrogates antichlamydial properties of ifn-y in human fallopian tube cells in vitro and ex vivo. Proc Natl Acad Sci U S A 107(45):19502\u201319507","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"178_CR94","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/npp.2014.190","volume":"40","author":"J Sacher","year":"2015","unstructured":"Sacher J, Rekkas PV, Wilson AA, Houle S, Romano L, Hamidi J et al (2015) Relationship of monoamine oxidase-A distribution volume to postpartum depression and postpartum crying. Neuropsychopharmacology 40(2):429\u2013435","journal-title":"Neuropsychopharmacology"},{"issue":"9","key":"178_CR95","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1097\/NEN.0000000000000107","volume":"73","author":"TP Schnieder","year":"2014","unstructured":"Schnieder TP, Trencevska I, Rosoklija G, Stankov A, Mann JJ, Smiley J et al (2014) Microglia of prefrontal white matter in suicide. J Neuropathol Exp Neurol 73(9):880\u2013890","journal-title":"J Neuropathol Exp Neurol"},{"issue":"72","key":"178_CR96","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0024-3205(02)02304-4","volume":"72","author":"K Schrocksnadel","year":"2003","unstructured":"Schrocksnadel K, Widner B, Bergant A, Neurauter G, Schennach H, Schrocksnadel H et al (2003a) Longitudinal study of tryptophan degradation during and after pregnancy. Life Sci 72(72):785\u2013793","journal-title":"Life Sci"},{"key":"178_CR97","doi-asserted-by":"crossref","unstructured":"Schr\u00f6cksnadel K, Widner B, Neurauter G, Fuchs D, Schr\u00f6cksnadel H, Bergant A (2003b) Tryptophan Degradation During And After Gestation. Developments in Tryptophan and Serotonin Metabolism. Springer US 527:77\u201383","DOI":"10.1007\/978-1-4615-0135-0_8"},{"issue":"7","key":"178_CR98","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrn3257","volume":"13","author":"R Schwarcz","year":"2012","unstructured":"Schwarcz R, Bruno JP, Muchowski PJ, Wu HQ (2012) Kynurenines in the mammalian brain: when physiology meets pathology. Nat Rev Neurosci 13(7):465\u2013477","journal-title":"Nat Rev Neurosci"},{"issue":"2","key":"178_CR99","first-page":"167","volume":"1","author":"DA Scrandis","year":"2008","unstructured":"Scrandis DA, Langenberg P, Tonelli LH, Sheikh TM, Manogura AC, Alberico LA et al (2008) Prepartum depressive symptoms correlate positively with c-reactive protein levels and negatively with tryptophan levels: a preliminary report. Int J Child Health Hum Dev 1(2):167\u2013174","journal-title":"Int J Child Health Hum Dev"},{"issue":"6","key":"178_CR100","first-page":"230","volume":"5","author":"P Sedlmayr","year":"2014","unstructured":"Sedlmayr P, Blaschitz A, Stocker R (2014) The role of placental tryptophan catabolism. Front Immunol 5(6):230","journal-title":"Front Immunol"},{"issue":"6","key":"178_CR101","doi-asserted-by":"crossref","first-page":"659","DOI":"10.2217\/WHE.12.55","volume":"8","author":"A Skalkidou","year":"2012","unstructured":"Skalkidou A, Hellgren C, Comasco E, Sylv\u00e9n S, Poromaa IS (2012) Biological aspects of postpartum depression. Women Health 8(6):659\u2013672","journal-title":"Women Health"},{"key":"178_CR102","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fncel.2015.00082","volume":"9","author":"J \u015alusarczyk","year":"2015","unstructured":"\u015alusarczyk J, Trojan E, G\u0142ombik K, Budziszewska B, Kubera M, Laso\u0144 W et al (2015) Prenatal stress is a vulnerability factor for altered morphology and biological activity of microglia cells. Front Cell Neurosci 9:82","journal-title":"Front Cell Neurosci"},{"issue":"3","key":"178_CR103","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1017\/S0924270800035432","volume":"12","author":"S Sobczak","year":"2000","unstructured":"Sobczak S, Honig A, Riedel WJ (2000) Acute tryptophan depletion in bipolar disorders; literature review and directives for further research. Acta Neuropsych 12(3):69\u201372","journal-title":"Acta Neuropsych"},{"issue":"1\u20132","key":"178_CR104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jns.2012.08.005","volume":"323","author":"L Tan","year":"2012","unstructured":"Tan L, Yu JT, Tan L (2012) The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerations. J Neurol Sci 323(1\u20132):1\u20138","journal-title":"J Neurol Sci"},{"issue":"5","key":"178_CR105","first-page":"338","volume":"5","author":"J Tang","year":"2015","unstructured":"Tang J, Xue W, Xia B, Li R, Tao W, Chen C et al (2015) Involvement of normalized nmda receptor and mtor-related signaling in rapid antidepressant effects of yueju and ketamine on chronically stressed mice. Sci Rep 5(5):338\u2013341","journal-title":"Sci Rep"},{"issue":"6","key":"178_CR106","doi-asserted-by":"crossref","first-page":"791","DOI":"10.2174\/187152710793237430","volume":"9","author":"MA Thevandavakkam","year":"2010","unstructured":"Thevandavakkam MA, Schwarcz R, Muchowski PJ, Giorgini F (2010) Targeting kynurenine 3-monooxygenase (kmo): implications for therapy in huntington's disease. CNS Neurol Disord Drug Targets 9(6):791\u2013800","journal-title":"CNS Neurol Disord Drug Targets"},{"issue":"2","key":"178_CR107","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1651-2227.1979.tb04989.x","volume":"68","author":"MD Tricklebank","year":"1979","unstructured":"Tricklebank MD, Pickard FJ, Souza SWD (1979) Free and bound tryptophan in human plasma during the perinatal period. Acta Paediatr Scand 68(2):199\u2013204","journal-title":"Acta Paediatr Scand"},{"key":"178_CR108","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jad.2015.09.064","volume":"189","author":"C Veen","year":"2016","unstructured":"Veen C, Myint AM, Burgerhout KM, Schwarz MJ, Sch\u00fctze G, Kushner SA et al (2016) Tryptophan pathway alterations in the postpartum period and in acute postpartum psychosis and depression. J Affect Disord 189:298\u2013305","journal-title":"J Affect Disord"},{"issue":"1","key":"178_CR109","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.psc.2015.10.002","volume":"39","author":"MF Wald","year":"2016","unstructured":"Wald MF, Muzyk AJ, Clark D (2016) Bipolar depression: pregnancy, postpartum, and lactation. Psychiatr Clin N Am 39(1):57\u201374","journal-title":"Psychiatr Clin N Am"},{"issue":"5","key":"178_CR110","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.neuron.2011.09.023","volume":"72","author":"CC Wang","year":"2011","unstructured":"Wang CC, Held RG, Chang SC, Yang L, Delpire E, Ghosh A et al (2011) A critical role for glun2b-containing nmda receptors in cortical development and function. Neuron 72(5):789\u2013805","journal-title":"Neuron"},{"issue":"4","key":"178_CR111","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/03009734.2015.1060281","volume":"120","author":"N Wang","year":"2015","unstructured":"Wang N, Yu HY, Shen XF, Gao ZQ, Yang C, Yang JJ et al (2015) The rapid antidepressant effect of ketamine in rats is associated with down-regulation of pro-inflammatory cytokines in the hippocampus. Ups J Med Sci 120(4):1\u20138","journal-title":"Ups J Med Sci"},{"issue":"1","key":"178_CR112","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1523\/JNEUROSCI.3561-14.2015","volume":"35","author":"MD Weber","year":"2015","unstructured":"Weber MD, Frank MG, Tracey KJ, Watkins LR, Maier SF (2015) Stress induces the danger-associated molecular pattern HMGB-1 in the hippocampus of male Sprague Dawley rats: a priming stimulus of microglia and the NLRP3 inflammasome. J Neurosci 35(1):316\u2013324","journal-title":"J Neurosci"},{"issue":"2013","key":"178_CR113","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.bbi.2012.12.018","volume":"29","author":"K Weigelt","year":"2013","unstructured":"Weigelt K, Bergink V, Burgerhout KM, Pescatori M, Wijkhuijs A, Drexhage HA (2013) Down-regulation of inflammation-protective micrornas 146a and 212 in monocytes of patients with postpartum psychosis. Brain Behav Immun 29(2013):147\u2013155","journal-title":"Brain Behav Immun"},{"issue":"6","key":"178_CR114","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/sj.mp.4001600","volume":"10","author":"MC Wichers","year":"2005","unstructured":"Wichers MC, Koek GH, Robaeys G, Verkerk R, Scharp\u00e9 S, Maes M (2005) Ido and interferon-alpha-induced depressive symptoms: a shift in hypothesis from tryptophan depletion to neurotoxicity. Mol Psychiatry 10(6):538\u2013544","journal-title":"Mol Psychiatry"},{"issue":"1","key":"178_CR115","first-page":"11","volume":"29","author":"MC Wichers","year":"2004","unstructured":"Wichers MC, Maes M (2004) The role of indoleamine 2,3-dioxygenase (ido) in the pathophysiology of interferon-alpha-induced depression. J Psychiatry Neurosci 29(1):11\u201317","journal-title":"J Psychiatry Neurosci"},{"issue":"9","key":"178_CR116","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1176\/ajp.153.9.1132","volume":"153","author":"KL Wisner","year":"1996","unstructured":"Wisner KL, Perel JM, Findling RL (1996) Antidepressant treatment during breast-feeding. Am J Psychiatr 153(9):1132\u20131137","journal-title":"Am J Psychiatr"},{"issue":"1","key":"178_CR117","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1742-2094-11-1","volume":"11","author":"W Xie","year":"2014","unstructured":"Xie W, Cai L, Yu Y, Gao L, Xiao L, He Q et al (2014) Activation of brain indoleamine 2,3-dioxygenase contributes to epilepsy-associated depressive-like behavior in rats with chronic temporal lobe epilepsy. J Neuroinflammation 11(1):1\u201310","journal-title":"J Neuroinflammation"},{"issue":"7","key":"178_CR118","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1055\/s-0034-1393704","volume":"63","author":"SQ Yi","year":"2015","unstructured":"Yi SQ, Yang M, Duan KM (2015) Immune-mediated metabolic kynurenine pathways are involved in the postoperative cognitive dysfunction after cardiopulmonary bypass. Thorac Cardiovasc Surg 63(7):618\u2013623","journal-title":"Thorac Cardiovasc Surg"},{"issue":"2","key":"178_CR119","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0006-3223(94)91201-7","volume":"35","author":"LT Young","year":"1994","unstructured":"Young LT, Warsh JJ, Kish SJ, Shannak K, Hornykeiwicz O (1994) Reduced brain 5-ht and elevated ne turnover and metabolites in bipolar affective disorder \u2606. Biol Psychiatry 35(2):121\u2013127","journal-title":"Biol Psychiatry"},{"issue":"1","key":"178_CR120","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/jop.12224","volume":"44","author":"Z Zhang","year":"2015","unstructured":"Zhang Z, Han Y, Song J, Luo R, Jin X, Mu D et al (2015) Interferon-\u03b3 regulates the function of mesenchymal stem cells from oral lichen planus via indoleamine 2,3-dioxygenase activity. J Oral Pathol Med 44(1):15\u201327","journal-title":"J Oral Pathol Med"},{"key":"178_CR121","doi-asserted-by":"crossref","unstructured":"Zhang S, Hong J, Zhang T, Wu J, Chen L (2017) Activation of sigma-1 receptor alleviates postpartum estrogen withdrawal-induced \u201cdepression\u201d through restoring hippocampal nnos-no-creb activities in mice. Mol Neurobiol 54(4):3017","DOI":"10.1007\/s12035-016-9872-8"},{"key":"178_CR122","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.nbd.2014.04.008","volume":"68","author":"Q Zhao","year":"2014","unstructured":"Zhao Q, Cheng P, Wu X, Chen Y, Wang C, You Z (2014) Maternal sleep deprivation inhibits hippocampal neurogenesis associated with inflammatory response in young offspring rats. Neurobiol Dis 68:57\u201365","journal-title":"Neurobiol Dis"},{"issue":"37","key":"178_CR123","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/npp.2011.277","volume":"37","author":"PA Zunszain","year":"2012","unstructured":"Zunszain PA, Anacker C, Cattaneo A, Choudhury S, Musaelyan K, Myint AM, Thuret S, Price J, Pariante CM (2012) Interleukin-1\u03b2: a new regulator of the kynurenine pathway affecting human hippocampal neurogenesis. Neuropsychopharmacology 37(37):939\u2013949","journal-title":"Neuropsychopharmacology"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11011-017-0178-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-017-0178-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-017-0178-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T12:34:36Z","timestamp":1693398876000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11011-017-0178-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,6]]},"references-count":123,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["178"],"URL":"https:\/\/doi.org\/10.1007\/s11011-017-0178-y","relation":{},"ISSN":["0885-7490","1573-7365"],"issn-type":[{"value":"0885-7490","type":"print"},{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,6]]}}}