{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:28:03Z","timestamp":1793147283780,"version":"4.5.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T00:00:00Z","timestamp":1523318400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017A030313448"],"award-info":[{"award-number":["2017A030313448"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703731"],"award-info":[{"award-number":["81703731"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010226","name":"Educational Commission of Guangdong Province","doi-asserted-by":"crossref","award":["2016KQNCX086"],"award-info":[{"award-number":["2016KQNCX086"]}],"id":[{"id":"10.13039\/501100010226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s11011-018-0216-4","type":"journal-article","created":{"date-parts":[[2018,4,9]],"date-time":"2018-04-09T21:56:41Z","timestamp":1523311001000},"page":"1175-1185","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Anxiolytic-like effects of paeoniflorin in an animal model of post traumatic stress disorder"],"prefix":"10.1007","volume":"33","author":[{"given":"Zhi-Kun","family":"Qiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Li","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Hong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Meng","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Hai","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Sheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,4,10]]},"reference":[{"key":"216_CR1","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1046\/j.1365-2826.2001.00676.x","volume":"13","author":"SF Akana","year":"2001","unstructured":"Akana SF, Chu A, Soriano L, Dallman MF (2001) Corticosterone exerts site-specific and state-dependent effects in prefrontal cortex and amygdala on regulation of adrenocorticotropic hormone, insulin and fat depots. J Neuroendocrinol 13:625\u2013637","journal-title":"J Neuroendocrinol"},{"key":"216_CR2","doi-asserted-by":"publisher","unstructured":"Akiki TJ, Averill CL, Wrocklage KM, Schweinsburg B, Scott JC, Martini B et al (2017) The association of PTSD symptom severity with localized hippocampus and amygdala abnormalities. Chron Stress (Thousand Oaks). \n                    https:\/\/doi.org\/10.1177\/2470547017724069","DOI":"10.1177\/2470547017724069"},{"key":"216_CR3","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.euroneuro.2015.12.021","volume":"26","author":"Y Bentefour","year":"2016","unstructured":"Bentefour Y, Rakibi Y, Bennis M, Ba-M'hamed S, Garcia R (2016) Paroxetine treatment, following behavioral suppression of PTSD-like symptoms in mice, prevents relapse by activating the infralimbic cortex. Eur Neuropsychopharmacol 26:195\u2013207","journal-title":"Eur Neuropsychopharmacol"},{"key":"216_CR4","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.jagp.2014.12.003","volume":"24","author":"MH Beristianos","year":"2016","unstructured":"Beristianos MH, Yaffe K, Cohen B, Byers AL (2016) PTSD and risk of incident cardiovascular disease in aging veterans. Am J Geriatr Psychiatry 24:192\u2013200","journal-title":"Am J Geriatr Psychiatry"},{"key":"216_CR5","doi-asserted-by":"crossref","unstructured":"de Kloet CS, Vermetten E, Rademaker AR, Geuze E, Westenberg HG (2012) Neuroendocrine and immune responses to a cognitive stress challenge in veterans with and without PTSD. Eur J Psychotraumatol 3","DOI":"10.3402\/ejpt.v3i0.16206"},{"key":"216_CR6","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.bbr.2013.09.014","volume":"256","author":"AL Eagle","year":"2013","unstructured":"Eagle AL, Fitzpatrick CJ, Perrine SA (2013) Single prolonged stress impairs social and object novelty recognition in rats. Behav Brain Res 256:591\u2013597","journal-title":"Behav Brain Res"},{"key":"216_CR7","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1037\/ccp0000080","volume":"84","author":"A Echiverri-Cohen","year":"2016","unstructured":"Echiverri-Cohen A, Zoellner LA, Gallop R, Feeny N, Jaeger J, Bedard-Gilligan M (2016) Changes in temporal attention inhibition following prolonged exposure and sertraline in the treatment of PTSD. J Consult Clin Psychol 84:415\u2013426","journal-title":"J Consult Clin Psychol"},{"key":"216_CR8","first-page":"315","volume":"4","author":"S Eskandarian","year":"2013","unstructured":"Eskandarian S, Vafaei AA, Vaezi GH, Taherian F, Kashefi A, Rashidy-Pour A (2013) Effects of systemic administration of oxytocin on contextual fear extinction in a rat model of post-traumatic stress disorder. Basic Clin Neurosci 4:315\u2013322","journal-title":"Basic Clin Neurosci"},{"key":"216_CR9","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1016\/j.euroneuro.2015.02.004","volume":"25","author":"D Fenchel","year":"2015","unstructured":"Fenchel D, Levkovitz Y, Vainer E, Kaplan Z, Zohar J, Cohen H (2015) Beyond the HPA-axis: the role of the gonadal steroid hormone receptors in modulating stress-related responses in an animal model of PTSD. Eur Neuropsychopharmacol 25:944\u2013957","journal-title":"Eur Neuropsychopharmacol"},{"key":"216_CR10","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.neuropharm.2011.08.049","volume":"62","author":"SP Fernandez","year":"2012","unstructured":"Fernandez SP, Gaspar P (2012) Investigating anxiety and depressive-like phenotypes in genetic mouse models of serotonin depletion. Neuropharmacology 62:144\u2013154","journal-title":"Neuropharmacology"},{"key":"216_CR11","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s00213-014-3635-x","volume":"232","author":"SA George","year":"2015","unstructured":"George SA, Rodriguez-Santiago M, Riley J, Rodriguez E, Liberzon I (2015) The effect of chronic phenytoin administration on single prolonged stress induced extinction retention deficits and glucocorticoid upregulation in the rat medial prefrontal cortex. Psychopharmacology 232:47\u201356","journal-title":"Psychopharmacology"},{"key":"216_CR12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069340","volume":"8","author":"F Han","year":"2013","unstructured":"Han F, Yan S, Shi Y (2013) Single-prolonged stress induces endoplasmic reticulum-dependent apoptosis in the hippocampus in a rat model of post-traumatic stress disorder. PLoS One 8:e69340","journal-title":"PLoS One"},{"key":"216_CR13","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.mbs.2015.08.004","volume":"268","author":"N Hosseinichimeh","year":"2015","unstructured":"Hosseinichimeh N, Rahmandad H, Wittenborn AK (2015) Modeling the hypothalamus-pituitary-adrenal axis: a review and extension. Math Biosci 268:52\u201365","journal-title":"Math Biosci"},{"key":"216_CR14","first-page":"5103","volume":"8","author":"H Huang","year":"2015","unstructured":"Huang H, Zhao J, Jiang L, Xie Y, Xia Y, Lv R (2015) Paeoniflorin improves menopause depression in ovariectomized rats under chronic unpredictable mild stress. Int J Clin Exp Med 8:5103\u20135011","journal-title":"Int J Clin Exp Med"},{"key":"216_CR15","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1177\/0269881116645298","volume":"30","author":"ZL Jin","year":"2016","unstructured":"Jin ZL, Liu JX, Liu X, Zhang LM, Ran YH, Zheng YY et al (2016) Anxiolytic effects of GLYX-13 in animal models of posttraumatic stress disorder-like behavior. Psychopharmacol 30:913\u2013921","journal-title":"Psychopharmacol"},{"key":"216_CR16","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1111\/ejn.12860","volume":"41","author":"CY Kao","year":"2015","unstructured":"Kao CY, Stalla G, Stalla J, Wotjak CT, Anderzhanova E (2015) Norepinephrine and corticosterone in the medial prefrontal cortex and hippocampus predict PTSD-like symptoms in mice. Eur J Neurosci 41:1139\u20131148","journal-title":"Eur J Neurosci"},{"key":"216_CR17","doi-asserted-by":"publisher","first-page":"459","DOI":"10.3325\/cmj.2008.4.459","volume":"49","author":"D Kozaric-Kovacic","year":"2008","unstructured":"Kozaric-Kovacic D (2008) Psychopharmacotherapy of posttraumatic stress disorder. Croat Med J 49:459\u2013475","journal-title":"Croat Med J"},{"key":"216_CR18","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.neuropharm.2013.07.005","volume":"75","author":"S Krishnamurthy","year":"2013","unstructured":"Krishnamurthy S, Garabadu D, Joy KP (2013) Risperidone ameliorates post-traumatic stress disorder-like symptoms in modified stress re-stress model. Neuropharmacology 75:62\u201377","journal-title":"Neuropharmacology"},{"key":"216_CR19","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.euroneuro.2014.11.012","volume":"25","author":"Y Levkovitz","year":"2015","unstructured":"Levkovitz Y, Fenchel D, Kaplan Z, Zohar J, Cohen H (2015) Early post-stressor intervention with minocycline, a second-generation tetracycline, attenuates post-traumatic stress response in an animal model of PTSD. Eur Neuropsychopharmacol 25:124\u2013132","journal-title":"Eur Neuropsychopharmacol"},{"key":"216_CR20","doi-asserted-by":"publisher","first-page":"2404","DOI":"10.1038\/npp.2009.66","volume":"34","author":"YF Li","year":"2009","unstructured":"Li YF, Huang Y, Amsdell SL, Xiao L, O'Donnell JM, Zhang HT (2009) Antidepressant- and anxiolytic-like effects of the phosphodiesterase-4 inhibitor rolipram on behavior depend on cyclic AMP response element binding protein-mediated neurogenesis in the hippocampus. Neuropsychopharmacology 34:2404\u20132419","journal-title":"Neuropsychopharmacology"},{"key":"216_CR21","doi-asserted-by":"publisher","first-page":"285","DOI":"10.5114\/fn.2014.45569","volume":"52","author":"J Li","year":"2014","unstructured":"Li J, Ji X, Zhang J, Shi G, Zhu X, Wang K (2014) Paeoniflorin attenuates A\u03b225-35-induced neurotoxicity in PC12 cells by preventing mitochondrial dysfunction. Folia Neuropathol 52:285\u2013290","journal-title":"Folia Neuropathol"},{"key":"216_CR22","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1016\/j.euroneuro.2016.06.004","volume":"26","author":"CC Lin","year":"2016","unstructured":"Lin CC, Tung CS, Lin PH, Huang CL, Liu YP (2016a) Traumatic stress causes distinctive effects on fear circuit catecholamines and the fear extinction profile in a rodent model of posttraumatic stress disorder. Eur Neuropsychopharmacol 26:1484\u20131495","journal-title":"Eur Neuropsychopharmacol"},{"key":"216_CR23","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1007\/s00213-015-4194-5","volume":"233","author":"CC Lin","year":"2016","unstructured":"Lin CC, Tung CS, Liu YP (2016b) Escitalopram reversed the traumatic stress-induced depressed and anxiety-like symptoms but not the deficits of fear memory. Psychopharmacology 233:1135\u20131146","journal-title":"Psychopharmacology"},{"key":"216_CR24","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1038\/npp.2015.190","volume":"41","author":"A MacNamara","year":"2016","unstructured":"MacNamara A, Rabinak CA, Kennedy AE, Fitzgerald DA, Liberzon I, Stein MB et al (2016) Emotion regulatory brain function and SSRI treatment in PTSD: neural correlates and predictors of change. Neuropsychopharmacology 41:611\u2013618","journal-title":"Neuropsychopharmacology"},{"key":"216_CR25","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.jep.2008.07.008","volume":"119","author":"QQ Mao","year":"2008","unstructured":"Mao QQ, Ip SP, Tsai SH, Che CT (2008) Antidepressant-like effect of peony glycosides in mice. J Ethnopharmacol 119:272\u2013275","journal-title":"J Ethnopharmacol"},{"key":"216_CR26","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/j.biopsych.2013.03.024","volume":"74","author":"JM McKlveen","year":"2013","unstructured":"McKlveen JM, Myers B, Flak JN, Bundzikova J, Solomon MB, Seroogy KB et al (2013) Role of prefrontal cortex glucocorticoid receptors in stress and emotion. Biol Psychiatry 74:672\u2013679","journal-title":"Biol Psychiatry"},{"key":"216_CR27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0101450","volume":"9","author":"YL Miao","year":"2014","unstructured":"Miao YL, Guo WZ, Shi WZ, Fang WW, Liu Y, Liu J et al (2014) Midazolam ameliorates the behavior deficits of a rat posttraumatic stress disorder model through dual 18 kDa translocator protein and central benzodiazepine receptor and neurosteroidogenesis. PLoS One 9:e101450","journal-title":"PLoS One"},{"key":"216_CR28","doi-asserted-by":"publisher","first-page":"5608","DOI":"10.2174\/138161212803530817","volume":"18","author":"C Muhtz","year":"2012","unstructured":"Muhtz C, Wiedemann K, Kellner M (2012) Panicogens in patients with Post-Traumatic Stress Disorder (PTSD). Curr Pharm Des 18:5608\u20135618","journal-title":"Curr Pharm Des"},{"key":"216_CR29","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1007\/s10529-013-1192-8","volume":"35","author":"KN Nam","year":"2013","unstructured":"Nam KN, Yae CG, Hong JW, Cho DH, Lee JH, Lee EH (2013) Paeoniflorin, a monoterpene glycoside, attenuates lipopolysaccharide-induced neuronal injury and brain microglial inflammatory response. Biotechnol Lett 35:1183\u20131189","journal-title":"Biotechnol Lett"},{"key":"216_CR30","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1037\/0735-7044.106.1.62","volume":"106","author":"MS Oitzl","year":"1992","unstructured":"Oitzl MS, de Kloet ER (1992) Selective corticosteroid antagonists modulate specific aspects of spatial orientation learning. Behav Neurosci 106:62\u201371","journal-title":"Behav Neurosci"},{"key":"216_CR31","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jad.2017.05.022","volume":"219","author":"TQ Oliveira","year":"2017","unstructured":"Oliveira TQ, Sousa CNS, Vasconcelos GS, de Sousa LC, de Oliveira AA, Patroc\u00ednio CFV et al (2017) Brain antioxidant effect of mirtazapine and reversal of sedation by its combination with alpha-lipoic acid in a model of depression induced by corticosterone. J Affect Disord 219:49\u201357","journal-title":"J Affect Disord"},{"key":"216_CR32","doi-asserted-by":"publisher","first-page":"135","DOI":"10.4149\/endo_2014_03_135","volume":"48","author":"K Ondicova","year":"2014","unstructured":"Ondicova K, Kvetnansky R, Mravec B (2014) Deafferentation of the hypothalamic paraventricular nucleus (PVN) exaggerates the sympathoadrenal system activity in stressed rats. Endocr Regul 48:135\u2013143","journal-title":"Endocr Regul"},{"key":"216_CR33","doi-asserted-by":"publisher","first-page":"pt6","DOI":"10.1126\/scisignal.2003327","volume":"5","author":"P Pervanidou","year":"2012","unstructured":"Pervanidou P, Chrousos GP (2012) Posttraumatic stress disorder in children and adolescents: neuroendocrine perspectives. Sci Signal 5:pt6. \n                    https:\/\/doi.org\/10.1126\/scisignal.2003327","journal-title":"Sci Signal"},{"key":"216_CR34","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.3892\/etm.2013.925","volume":"5","author":"F Qiu","year":"2013","unstructured":"Qiu F, Zhong X, Mao Q, Huang Z (2013) The antidepressant-like effects of paeoniflorin in mouse models. Exp Ther Med 5:1113\u20131116","journal-title":"Exp Ther Med"},{"key":"216_CR35","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1007\/s11011-016-9853-7","volume":"31","author":"ZK Qiu","year":"2016","unstructured":"Qiu ZK, Liu CH, Gao ZW, He JL, Liu X, Wei QL et al (2016) The inulin-type oligosaccharides extract from morinda officinalis, a traditional Chinese herb, ameliorated behavioral deficits in an animal model of post-traumatic stress disorder. Metab Brain Dis 31:1143\u20131149","journal-title":"Metab Brain Dis"},{"key":"216_CR36","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.psyneuen.2016.08.015","volume":"74","author":"C Raineki","year":"2016","unstructured":"Raineki C, Chew L, Mok P, Ellis L, Weinberg J (2016) Short- and long-term effects of stress during adolescence on emotionality and HPA function of animals exposed to alcohol prenatally. Psychoneuroendocrinology 74:13\u201323","journal-title":"Psychoneuroendocrinology"},{"key":"216_CR37","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.jpsychires.2015.10.006","volume":"71","author":"AM Reid","year":"2015","unstructured":"Reid AM, McNamara JP, Murphy TK, Guzick AG, Storch EA, Goodman WK et al (2015) Side-effects of SSRIs disrupt multimodal treatment for pediatric OCD in a randomized-controlled trial. J Psychiatr Res 71:140\u2013147","journal-title":"J Psychiatr Res"},{"key":"216_CR38","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1038\/nn766","volume":"4","author":"B Roozendaal","year":"2001","unstructured":"Roozendaal B, Phillips RG, Power AE, Brooke SM, Sapolsky RM, McGaugh JL (2001) Memory retrieval impairment induced by hippocampal CA3 lesions is blocked by adrenocortical suppression. Nat Neurosci 4:1169\u20131171","journal-title":"Nat Neurosci"},{"key":"216_CR39","first-page":"1","volume":"29","author":"CJ Santos","year":"2016","unstructured":"Santos CJ, Ferreira AV, Oliveira AL, Oliveira MC, Gomes JS, Aguiar DC (2016) Carbohydrate-enriched diet predispose to anxiety and depression-like behavior after stress in mice. Nutr Neurosci 29:1\u20137","journal-title":"Nutr Neurosci"},{"key":"216_CR40","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1530\/JOE-13-0027","volume":"218","author":"N Uschold-Schmidt","year":"2013","unstructured":"Uschold-Schmidt N, Peterlik D, F\u00fcchsl AM, Reber SO (2013) HPA axis changes during the initial phase of psychosocial stressor exposure in male mice. J Endocrinol 218:193\u2013203","journal-title":"J Endocrinol"},{"key":"216_CR41","doi-asserted-by":"publisher","unstructured":"van Rooij SJH, Stevens JS, Ely TD, Hinrichs R, Michopoulos V, Winters SJ, Ogbonmwan YE (2017) The role of the hippocampus in predicting future posttraumatic stress disorder symptoms in recently traumatized civilians. Biol Psychiatry. \n                    https:\/\/doi.org\/10.1016\/j.biopsych.2017.09.005","DOI":"10.1016\/j.biopsych.2017.09.005"},{"key":"216_CR42","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1016\/j.pnpbp.2009.07.031","volume":"33","author":"HN Wang","year":"2009","unstructured":"Wang HN, Peng Y, Tan QR, Wang HH, Chen YC, Zhang RG et al (2009) Free and Easy Wanderer Plus (FEWP), a polyherbal preparation, ameliorates PTSD-like behavior and cognitive impairments in stressed rats. Prog Neuro-Psychopharmacol Biol Psychiatry 33:1458\u20131463","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"216_CR43","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.3109\/13880209.2014.880490","volume":"52","author":"QS Wang","year":"2014","unstructured":"Wang QS, Gao T, Cui YL, Gao LN, Jiang HL (2014) Comparative studies of paeoniflorin and albiflorin from Paeonia lactiflora on anti-inflammatory activities. Pharm Biol 52:1189\u20131195","journal-title":"Pharm Biol"},{"key":"216_CR44","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jep.2015.12.029","volume":"179","author":"YL Wang","year":"2016","unstructured":"Wang YL, Wang JX, Hu XX, Chen L, Qiu ZK, Zhao N et al (2016) Antidepressant-like effects of albiflorin extracted from Radix paeoniae Alba. J Ethnopharmacol 179:9\u201315","journal-title":"J Ethnopharmacol"},{"key":"216_CR45","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1007\/s10495-017-1371-5","volume":"22","author":"L Wen","year":"2017","unstructured":"Wen L, Xiao B, Shi Y, Han F (2017) PERK signalling pathway mediates single prolonged stress-induced dysfunction of medial prefrontal cortex neurons. Apoptosis 22:753\u2013768","journal-title":"Apoptosis"},{"key":"216_CR46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089104","volume":"9","author":"CB Wilson","year":"2014","unstructured":"Wilson CB, Ebenezer PJ, McLaughlin LD, Francis J (2014) Predator exposure\/psychosocial stress animal model of post-traumatic stress disorder modulates neurotransmitters in the rat hippocampus and prefrontal cortex. PLoS One 9:e89104","journal-title":"PLoS One"},{"key":"216_CR47","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.euroneuro.2012.06.001","volume":"23","author":"R Xue","year":"2013","unstructured":"Xue R, Jin ZL, Chen HX, Yuan L, He XH, Zhang YP et al (2013) Antidepressant-like effects of 071031B, a novel serotonin and norepinephrine reuptake inhibitor. Eur Neuropsychopharmacol 23:728\u2013741","journal-title":"Eur Neuropsychopharmacol"},{"key":"216_CR48","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1055\/s-2001-18364","volume":"67","author":"J Ye","year":"2001","unstructured":"Ye J, Duan H, Yang X, Yan W, Zheng X (2001) Anti-thrombosis effect of paeoniflorin: evaluated in a photochemical reaction thrombosis model in vivo. Planta Med 67:766\u2013767","journal-title":"Planta Med"},{"key":"216_CR49","doi-asserted-by":"publisher","first-page":"20140048","DOI":"10.1098\/rsfs.2014.0048","volume":"4","author":"R Yehuda","year":"2014","unstructured":"Yehuda R, Pratchett LC, Elmes MW, Lehrner A, Daskalakis NP, Koch E et al (2014) Glucocorticoid-related predictors and correlates of post-traumatic stress disorder treatment response in combat veterans. Interface Focus 4:20140048","journal-title":"Interface Focus"},{"key":"216_CR50","doi-asserted-by":"publisher","first-page":"26524","DOI":"10.3402\/ejpt.v5.26524","volume":"5","author":"YH Zhang","year":"2014","unstructured":"Zhang YH (2014) The treatment and research for posttraumatic stress disorder with Chinese medicine. Eur J Psychotraumatol 5:26524","journal-title":"Eur J Psychotraumatol"},{"key":"216_CR51","first-page":"623753","volume":"2012","author":"LM Zhang","year":"2012","unstructured":"Zhang LM, Yao JZ, Li Y, Li K, Chen HX, Zhang YZ et al (2012) Anxiolytic effects of flavonoids in animal models of posttraumatic stress disorder. Evid Based Complement Alternat Med 2012:623753","journal-title":"Evid Based Complement Alternat Med"},{"key":"216_CR52","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1017\/S1461145714000479","volume":"17","author":"LM Zhang","year":"2014","unstructured":"Zhang LM, Qiu ZK, Zhao N, Chen HX, Liu YQ, Xu JP et al (2014) Anxiolytic-like effects of YL-IPA08, a potent ligand for the translocator protein (18 kDa) in animal models of post-traumatic stress disorder. Int J Neuropsychopharmacol 17:1659\u20131669","journal-title":"Int J Neuropsychopharmacol"},{"key":"216_CR53","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.ejphar.2007.12.005","volume":"581","author":"Y Zhao","year":"2008","unstructured":"Zhao Y, Ma R, Shen J, Su H, Xing D, Du L (2008) A mouse model of depression induced by repeated corticosterone injections. Eur J Pharmacol 581:113\u2013120","journal-title":"Eur J Pharmacol"},{"key":"216_CR54","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1267\/ahc.08013","volume":"41","author":"D Zhe","year":"2008","unstructured":"Zhe D, Fang H, Yuxiu S (2008) Expressions of hippocampal mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) in the single-prolonged stress-rats. Acta Histochem Cytochem 41:89\u201395","journal-title":"Acta Histochem Cytochem"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11011-018-0216-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-018-0216-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-018-0216-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T19:53:46Z","timestamp":1554839626000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11011-018-0216-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,10]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["216"],"URL":"https:\/\/doi.org\/10.1007\/s11011-018-0216-4","relation":{},"ISSN":["0885-7490","1573-7365"],"issn-type":[{"value":"0885-7490","type":"print"},{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,10]]},"assertion":[{"value":"4 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors have declared that no competing interests exist.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}