{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T14:30:13Z","timestamp":1785594613922,"version":"3.56.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T00:00:00Z","timestamp":1529539200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Department of Bio-Technology (DBT), Govt. of India, New Delhi","award":["BT\/361\/NE\/TBP\/2012"],"award-info":[{"award-number":["BT\/361\/NE\/TBP\/2012"]}]},{"name":"University Grants Commission (UGC), New Delhi","award":["[F.17-7(J)\/2004(SA-1)]"],"award-info":[{"award-number":["[F.17-7(J)\/2004(SA-1)]"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1007\/s11011-018-0268-5","type":"journal-article","created":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T01:00:56Z","timestamp":1529542856000},"page":"1617-1624","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Methylenetetrahydrofolate reductase C677T variant and hyperhomocysteinemia in subarachnoid hemorrhage patients from India"],"prefix":"10.1007","volume":"33","author":[{"given":"Mohit","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Goudihalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanchan","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivashanmugam","family":"Dhandapani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajat","family":"Sandhir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,6,21]]},"reference":[{"key":"268_CR1","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s10143-017-0843-y","volume":"41","author":"A Aggarwal","year":"2018","unstructured":"Aggarwal A, Dhandapani S, Praneeth K et al (2018) Comparative evaluation of H&H and WFNS grading scales with modified H&H (sans systemic disease): A study on 1000 patients with subarachnoid hemorrhage. Neurosurg Rev 41:241\u2013247. https:\/\/doi.org\/10.1007\/s10143-017-0843-y","journal-title":"Neurosurg Rev"},{"key":"268_CR2","doi-asserted-by":"publisher","first-page":"631","DOI":"10.4103\/0028-3886.57821","volume":"57","author":"N Al-Allawi","year":"2009","unstructured":"Al-Allawi N, Avo A, Jubrael J (2009) Methylenetetrahydrofolate reductase C677T polymorphism in Iraqi patients with ischemic stroke. Neurol India 57:631. https:\/\/doi.org\/10.4103\/0028-3886.57821","journal-title":"Neurol India"},{"key":"268_CR3","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1111\/j.1468-1331.2004.00938.x","volume":"12","author":"RV Alluri","year":"2005","unstructured":"Alluri RV, Mohan V, Komandur S et al (2005) MTHFR C677T gene mutation as a risk factor for arterial stroke: a hospital based study. Eur J Neurol 12:40\u201344. https:\/\/doi.org\/10.1111\/j.1468-1331.2004.00938.x","journal-title":"Eur J Neurol"},{"issue":"4","key":"268_CR4","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1093\/ajcn\/79.4.619","volume":"79","author":"Emile K Amouzou","year":"2004","unstructured":"Amouzou EK, Chabi NW, Adjalla CE et al (2004) High prevalence of hyperhomocysteinemia related to folate deficiency and the 677C>T mutation of the gene encoding methylenetetrahydrofolate reductase in coastal West Africa. Am J Clin Nutr 79:619\u2013624","journal-title":"The American Journal of Clinical Nutrition"},{"key":"268_CR5","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.yexmp.2004.04.006","volume":"77","author":"T Angeline","year":"2004","unstructured":"Angeline T, Jeyaraj N, Granito S, Tsongalis GJ (2004) Prevalence of MTHFR gene polymorphisms (C677T and A1298C) among Tamilians. Exp Mol Pathol 77:85\u201388. https:\/\/doi.org\/10.1016\/j.yexmp.2004.04.006","journal-title":"Exp Mol Pathol"},{"key":"268_CR6","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s10038-006-0098-x","volume":"52","author":"I Banerjee","year":"2007","unstructured":"Banerjee I, Gupta V, Ganesh S (2007) Association of gene polymorphism with genetic susceptibility to stroke in Asian populations: a meta-analysis. J Hum Genet 52:205\u2013219. https:\/\/doi.org\/10.1007\/s10038-006-0098-x","journal-title":"J Hum Genet"},{"issue":"Suppl","key":"268_CR7","doi-asserted-by":"publisher","first-page":"128","DOI":"10.2176\/nmc.38.suppl_128","volume":"38","author":"SN Bhagwati","year":"1998","unstructured":"Bhagwati SN (1998) Incidence of subarachnoid hemorrhage from aneurysmal rupture in India. Neurol Med Chir 38(Suppl):128\u2013130","journal-title":"Neurol Med Chir"},{"key":"268_CR8","doi-asserted-by":"publisher","first-page":"149","DOI":"10.2310\/6670.2007.00031","volume":"15","author":"S Bhargava","year":"2007","unstructured":"Bhargava S, Parakh R, Manocha A et al (2007) Prevalence of Hyperhomocysteinemia in Vascular Disease: Comparative Study of Thrombotic Venous Disease Vis-\u00e8-Vis Occlusive Arterial Disease. Vascular 15:149\u2013153. https:\/\/doi.org\/10.2310\/6670.2007.00031","journal-title":"Vascular"},{"key":"268_CR9","doi-asserted-by":"publisher","first-page":"57","DOI":"10.4103\/1793-5482.92159","volume":"6","author":"AR Bhat","year":"2011","unstructured":"Bhat AR, Afzalwani M, Kirmani AR (2011) Subarachnoid hemorrhage in Kashmir: Causes, risk factors, and outcome. Asian J Neurosurg 6:57\u201371. https:\/\/doi.org\/10.4103\/1793-5482.92159","journal-title":"Asian J Neurosurg"},{"key":"268_CR10","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.jstrokecerebrovasdis.2008.09.014","volume":"18","author":"A Biswas","year":"2009","unstructured":"Biswas A, Ranjan R, Meena A et al (2009) Homocystine Levels, Polymorphisms and the Risk of Ischemic Stroke in Young Asian Indians. J Stroke Cerebrovasc Dis 18:103\u2013110. https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2008.09.014","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"268_CR11","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1007\/s11239-012-0856-x","volume":"36","author":"F Cacciapuoti","year":"2013","unstructured":"Cacciapuoti F (2013) Lowering homocysteine levels with folic acid and B-vitamins do not reduce early atherosclerosis, but could interfere with cognitive decline and Alzheimer\u2019s disease. J Thromb Thrombolysis 36:258\u2013262. https:\/\/doi.org\/10.1007\/s11239-012-0856-x","journal-title":"J Thromb Thrombolysis"},{"key":"268_CR12","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1161\/01.STR.0000169946.31639.af","volume":"36","author":"S Cronin","year":"2005","unstructured":"Cronin S, Furie KL, Kelly PJ (2005) Dose-Related Association of MTHFR 677T Allele With Risk of Ischemic Stroke: Evidence From a Cumulative Meta-Analysis. Stroke 36:1581\u20131587. https:\/\/doi.org\/10.1161\/01.STR.0000169946.31639.af","journal-title":"Stroke"},{"issue":"11","key":"268_CR13","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1089\/gtmb.2011.0024","volume":"15","author":"Seetha Dayakar","year":"2011","unstructured":"Dayakar S, Goud KI, Reddy TPK et al (2011) Sequence Variation of the Methylene Tetrahydrofolate Reductase Gene (677C>T and 1298A>C) and Traditional Risk Factors in a South Indian Population. Gen Test Mol Biomarkers 15:765\u2013769. https:\/\/doi.org\/10.1089\/gtmb.2011.0024","journal-title":"Genetic Testing and Molecular Biomarkers"},{"key":"268_CR14","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S0973-0508(10)80007-3","volume":"7","author":"SS Dhandapani","year":"2010","unstructured":"Dhandapani SS, Manju D, Vivekanandhan S et al (2010) Prospective longitudinal study of biochemical changes in critically ill patients with severe traumatic brain injury: Factors associated and outcome at 6 months. Indian J Neurotrauma 7:23\u201327. https:\/\/doi.org\/10.1016\/S0973-0508(10)80007-3","journal-title":"Indian J Neurotrauma"},{"issue":"Suppl 21","key":"268_CR15","doi-asserted-by":"publisher","first-page":"S543","DOI":"10.4103\/2152-7806.168067","volume":"6","author":"S Dhandapani","year":"2015","unstructured":"Dhandapani S, Aggarwal A, Srinivasan A et al (2015a) Serum lipid profile spectrum and delayed cerebral ischemia following subarachnoid hemorrhage: Is there a relation?. Surgical neurology international. 2015 6(Suppl 21):S543. https:\/\/doi.org\/10.4103\/2152-7806.168067","journal-title":"2015"},{"key":"268_CR16","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s00701-014-2297-0","volume":"157","author":"S Dhandapani","year":"2015","unstructured":"Dhandapani S, Goudihalli S, Mukherjee KK et al (2015b) Prospective study of the correlation between admission plasma homocysteine levels and neurological outcome following subarachnoid hemorrhage: A case for the reverse epidemiology paradox? Acta Neurochir 157:399\u2013407. https:\/\/doi.org\/10.1007\/s00701-014-2297-0","journal-title":"Acta Neurochir"},{"key":"268_CR17","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s10143-017-0880-6","volume":"41","author":"S Dhandapani","year":"2018","unstructured":"Dhandapani S, Bajaj A, Gendle C et al (2018) Independent impact of plasma homocysteine levels on neurological outcome following head injury. Neurosurg Rev 41:513\u2013517. https:\/\/doi.org\/10.1007\/s10143-017-0880-6","journal-title":"Neurosurg Rev"},{"key":"268_CR18","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1046\/j.0022-3042.2001.00676.x","volume":"80","author":"W Duan","year":"2002","unstructured":"Duan W, Ladenheim B, Cutler RG et al (2002) Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson\u2019s disease. J Neurochem 80:101\u2013110","journal-title":"J Neurochem"},{"key":"268_CR19","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-14-6","volume":"14","author":"P Ganguly","year":"2015","unstructured":"Ganguly P, Alam SF (2015) Role of homocysteine in the development of cardiovascular disease. Nutr J 14:6. https:\/\/doi.org\/10.1186\/1475-2891-14-6","journal-title":"Nutr J"},{"key":"268_CR20","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1172\/JCI10588","volume":"107","author":"MA Hofmann","year":"2001","unstructured":"Hofmann MA, Lalla E, Lu Y et al (2001) Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model. J Clin Invest 107:675\u2013683. https:\/\/doi.org\/10.1172\/JCI10588","journal-title":"J Clin Invest"},{"key":"268_CR21","first-page":"S39","volume":"17","author":"MM Hoque","year":"2008","unstructured":"Hoque MM, Rahman MZ, Rahman MR (2008) Role of homocysteine in cerebrovascular disease. Mymensingh Medical Journal\u00a0: MMJ 17:S39\u2013S42","journal-title":"Mymensingh Medical Journal\u00a0: MMJ"},{"key":"268_CR22","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1080\/00207454.2016.1183126","volume":"127","author":"S Jiang","year":"2017","unstructured":"Jiang S, Li J, Zhang Y et al (2017) Methylenetetrahydrofolate reductase C677T polymorphism, hypertension and risk of stroke: a prospective, nested case-control study. Int J Neurosci 127:253\u2013260. https:\/\/doi.org\/10.1080\/00207454.2016.1183126","journal-title":"Int J Neurosci"},{"key":"268_CR23","doi-asserted-by":"publisher","first-page":"260","DOI":"10.4103\/0028-3886.27148","volume":"54","author":"J Kalita","year":"2006","unstructured":"Kalita J, Srivastava R, Bansal V et al (2006) Methylenetetrahydrofolate reductase gene polymorphism in Indian stroke patients. Neurol India 54:260\u2013263. https:\/\/doi.org\/10.4103\/0028-3886.27148","journal-title":"Neurol India"},{"key":"268_CR24","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/0026-0495(88)90076-5","volume":"37","author":"SS Kang","year":"1988","unstructured":"Kang SS, Wong PW, Zhou JM et al (1988) Thermolabile methylenetetrahydrofolate reductase in patients with coronary artery disease. Metab Clin Exp 37:611\u2013613","journal-title":"Metab Clin Exp"},{"key":"268_CR25","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1089\/gtmb.2012.0295","volume":"17","author":"S Kang","year":"2013","unstructured":"Kang S, Zhao X, Liu L et al (2013) Association of the C677T polymorphism in the MTHFR gene with hemorrhagic stroke: a meta-analysis. Gen Test Mol Biomarkers 17:412\u2013417. https:\/\/doi.org\/10.1089\/gtmb.2012.0295","journal-title":"Gen Test Mol Biomarkers"},{"key":"268_CR26","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1007\/s10038-005-0313-1","volume":"50","author":"J Kumar","year":"2005","unstructured":"Kumar J, Das SK, Sharma P et al (2005) Homocysteine levels are associated with MTHFR A1298C polymorphism in Indian population. J Hum Genet 50:655\u2013663. https:\/\/doi.org\/10.1007\/s10038-005-0313-1","journal-title":"J Hum Genet"},{"key":"268_CR27","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1002\/biof.1354","volume":"43","author":"M Kumar","year":"2017","unstructured":"Kumar M, Modi M, Sandhir R (2017) Hydrogen sulfide attenuates homocysteine-induced cognitive deficits and neurochemical alterations by improving endogenous hydrogen sulfide levels. BioFactors 43:434\u2013450. https:\/\/doi.org\/10.1002\/biof.1354","journal-title":"BioFactors"},{"key":"268_CR28","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1161\/01.STR.0000086753.00555.0D","volume":"34","author":"Z Li","year":"2003","unstructured":"Li Z, Sun L, Zhang H et al (2003) Elevated Plasma Homocysteine Was Associated With Hemorrhagic and Ischemic Stroke, but Methylenetetrahydrofolate Reductase Gene C677T Polymorphism Was a Risk Factor for Thrombotic Stroke: A Multicenter Case-Control Study in China. Stroke 34:2085\u20132090. https:\/\/doi.org\/10.1161\/01.STR.0000086753.00555.0D","journal-title":"Stroke"},{"key":"268_CR29","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1080\/01616412.2017.1297340","volume":"39","author":"S Liu","year":"2017","unstructured":"Liu S, Wu Y, Liu X et al (2017) Lack of association between MTHFR A1298C variant and Alzheimer\u2019s disease: evidence from a systematic review and cumulative meta-analysis. Neurol Res 39:426\u2013434. https:\/\/doi.org\/10.1080\/01616412.2017.1297340","journal-title":"Neurol Res"},{"key":"268_CR30","doi-asserted-by":"publisher","first-page":"4161","DOI":"10.4238\/2015.April.27.31","volume":"14","author":"Q-Q Lv","year":"2015","unstructured":"Lv Q-Q, Lu J, Sun H, Zhang J-S (2015) Association of methylenetetrahydrofolate reductase (MTHFR) gene polymorphism with ischemic stroke in the Eastern Chinese Han population. Genet Mol Res 14:4161\u20134168. https:\/\/doi.org\/10.4238\/2015.April.27.31","journal-title":"Genet Mol Res"},{"issue":"5","key":"268_CR31","doi-asserted-by":"publisher","first-page":"1003.e1-1003.e8","DOI":"10.1016\/j.neurobiolaging.2011.09.018","volume":"33","author":"Nasim Mansoori","year":"2012","unstructured":"Mansoori N, Tripathi M, Luthra K, et al (2012) MTHFR (677 and 1298) and IL-6-174 G\/C genes in pathogenesis of Alzheimer\u2019s and vascular dementia and their epistatic interaction. Neurobiol Aging 33:1003.e1\u20131001003.e8. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2011.09.018","journal-title":"Neurobiology of Aging"},{"key":"268_CR32","first-page":"297-301-2","volume":"53","author":"M Modi","year":"2005","unstructured":"Modi M, Prabhakar S, Majumdar S et al (2005) Hyperhomocysteinemia as a risk factor for ischemic stroke: an Indian scenario. Neurol India 53:297-301-2","journal-title":"Neurol India"},{"key":"268_CR33","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1111\/j.1468-1331.2008.02308.x","volume":"15","author":"KT Moe","year":"2008","unstructured":"Moe KT, Woon FP, De Silva DA et al (2008) Association of acute ischemic stroke with the MTHFR C677T polymorphism but not with NOS3 gene polymorphisms in a Singapore population. Eur J Neurol 15:1309\u20131314. https:\/\/doi.org\/10.1111\/j.1468-1331.2008.02308.x","journal-title":"Eur J Neurol"},{"key":"268_CR34","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1161\/01.ATV.18.9.1465","volume":"18","author":"H Morita","year":"1998","unstructured":"Morita H, Kurihara H, Tsubaki S et al (1998) Methylenetetrahydrofolate reductase gene polymorphism and ischemic stroke in Japanese. Arterioscler Thromb Vasc Biol 18:1465\u20131469","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"268_CR35","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1111\/andr.12351","volume":"5","author":"R Najafipour","year":"2017","unstructured":"Najafipour R, Moghbelinejad S, Aleyasin A, Jalilvand A (2017) Effect of B9 and B12 vitamin intake on semen parameters and fertility of men with MTHFR polymorphisms. Andrology 5:704\u2013710. https:\/\/doi.org\/10.1111\/andr.12351","journal-title":"Andrology"},{"key":"268_CR36","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1016\/j.clinbiochem.2009.04.015","volume":"42","author":"PA Norambuena","year":"2009","unstructured":"Norambuena PA, Copeland JA, K\u0159enkov\u00e1 P et al (2009) Diagnostic method validation: High resolution melting (HRM) of small amplicons genotyping for the most common variants in the MTHFR gene. Clin Biochem 42:1308\u20131316. https:\/\/doi.org\/10.1016\/j.clinbiochem.2009.04.015","journal-title":"Clin Biochem"},{"key":"268_CR37","first-page":"48-50-2","volume":"54","author":"I Panigrahi","year":"2006","unstructured":"Panigrahi I, Chatterjee T, Biswas A et al (2006) Role of MTHFR C677T polymorphism in ischemic stroke. Neurol India 54:48-50-2","journal-title":"Neurol India"},{"key":"268_CR38","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s12291-015-0512-2","volume":"31","author":"V Rai","year":"2016","unstructured":"Rai V (2016a) Folate Pathway Gene Methylenetetrahydrofolate Reductase C677T Polymorphism and Alzheimer Disease Risk in Asian Population. Indian J Clin Biochem 31:245\u2013252. https:\/\/doi.org\/10.1007\/s12291-015-0512-2","journal-title":"Indian J Clin Biochem"},{"key":"268_CR39","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1007\/s11011-016-9815-0","volume":"31","author":"V Rai","year":"2016","unstructured":"Rai V (2016b) Association of methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism with autism: evidence of genetic susceptibility. Metab Brain Dis 31:727\u2013735. https:\/\/doi.org\/10.1007\/s11011-016-9815-0","journal-title":"Metab Brain Dis"},{"issue":"3","key":"268_CR40","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.bpsc.2016.09.005","volume":"2","author":"Florence F. Roussotte","year":"2017","unstructured":"Roussotte FF, Hua X, Narr KL et al (2017) Archival Report The C677T Variant in MTHFR Modulates Associations Between Brain Integrity, Mood, and Cognitive Functioning in Old Age. Biol Psychiatry. https:\/\/doi.org\/10.1016\/j.bpsc.2016.09.005","journal-title":"Biological Psychiatry: Cognitive Neuroscience and Neuroimaging"},{"issue":"1","key":"268_CR41","doi-asserted-by":"publisher","first-page":"pdb.prot4455","DOI":"10.1101\/pdb.prot4455","volume":"2006","author":"Joseph Sambrook","year":"2006","unstructured":"Sambrook J, Russell DW (2006) Purification of nucleic acids by extraction with phenol:chloroform. CSH Protocols 2006. https:\/\/doi.org\/10.1101\/pdb.prot4455","journal-title":"Cold Spring Harbor Protocols"},{"key":"268_CR42","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1002\/ajhb.20682","volume":"20","author":"KN Saraswathy","year":"2008","unstructured":"Saraswathy KN, Mukhopadhyay R, Sinha E et al (2008) MTHFR C677T polymorphisms among the Ahirs and Jats of Haryana (India). Am J Hum Biol 20:116\u2013117. https:\/\/doi.org\/10.1002\/ajhb.20682","journal-title":"Am J Hum Biol"},{"key":"268_CR43","doi-asserted-by":"crossref","first-page":"119","DOI":"10.18388\/abp.2008_3161","volume":"55","author":"W Sawu\u0142a","year":"2008","unstructured":"Sawu\u0142a W, Banecka-Majkutewicz Z, Kadzi\u0144ski L et al (2008) Improved HPLC method for total plasma homocysteine detection and quantification. Acta Biochim Pol 55:119\u2013125","journal-title":"Acta Biochim Pol"},{"key":"268_CR44","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.reprotox.2017.07.001","volume":"72","author":"D Serapinas","year":"2017","unstructured":"Serapinas D, Boreikaite E, Bartkeviciute A et al (2017) The importance of folate, vitamins B6 and B12 for the lowering of homocysteine concentrations for patients with recurrent pregnancy loss and MTHFR mutations. Reprod Toxicol 72:159\u2013163. https:\/\/doi.org\/10.1016\/j.reprotox.2017.07.001","journal-title":"Reprod Toxicol"},{"issue":"10","key":"268_CR45","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.3390\/ijms17101733","volume":"17","author":"Henrieta \u0160kovierov\u00e1","year":"2016","unstructured":"\u0160kovierov\u00e1 H, Vidomanov\u00e1 E, Mahmood S, et al (2016) The Molecular and Cellular Effect of Homocysteine Metabolism Imbalance on Human Health. Int J Mol Sci 17. https:\/\/doi.org\/10.3390\/ijms17101733","journal-title":"International Journal of Molecular Sciences"},{"key":"268_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0012244","volume":"5","author":"AD Smith","year":"2010","unstructured":"Smith AD, Smith SM, de Jager CA et al (2010) Homocysteine-lowering by b vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: A randomized controlled trial. PLoS One 5:1\u201310. https:\/\/doi.org\/10.1371\/journal.pone.0012244","journal-title":"PLoS One"},{"key":"268_CR47","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1590\/S1415-47572010005000026","volume":"33","author":"R Tripathi","year":"2010","unstructured":"Tripathi R, Tewari S, Singh PK, Agarwal S (2010) Association of homocysteine and methylene tetrahydrofolate reductase (MTHFR C677T) gene polymorphism with coronary artery disease (CAD) in the population of North India. Genet Mol Biol 33:224\u2013228. https:\/\/doi.org\/10.1590\/S1415-47572010005000026","journal-title":"Genet Mol Biol"},{"key":"268_CR48","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/S0140-6736(07)60153-6","volume":"369","author":"J Gijn van","year":"2007","unstructured":"van Gijn J, Kerr RS, Rinkel GJE et al (2007) Subarachnoid haemorrhage. Lancet (London, England) 369:306\u2013318. https:\/\/doi.org\/10.1016\/S0140-6736(07)60153-6","journal-title":"Lancet (London, England)"},{"issue":"8","key":"268_CR49","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1136\/jmg.40.8.619","volume":"40","author":"B Wilcken","year":"2003","unstructured":"Wilcken B, Bamforth F, Li Z et al (2003) Geographical and ethnic variation of the 677C>T allele of 5,10 methylenetetrahydrofolate reductase (MTHFR): findings from over 7000 newborns from 16 areas world wide. J Med Genet 40:619\u2013625. https:\/\/doi.org\/10.1136\/jmg.40.8.619","journal-title":"Journal of Medical Genetics"},{"key":"268_CR50","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.ajp.2016.02.002","volume":"20","author":"U Yadav","year":"2016","unstructured":"Yadav U, Kumar P, Gupta S, Rai V (2016) Role of MTHFR C677T gene polymorphism in the susceptibility of schizophrenia: An updated meta-analysis. Asian J Psychiatr 20:41\u201351. https:\/\/doi.org\/10.1016\/j.ajp.2016.02.002","journal-title":"Asian J Psychiatr"},{"key":"268_CR51","doi-asserted-by":"publisher","first-page":"3268","DOI":"10.12659\/MSM.900010","volume":"22","author":"E-S Yao","year":"2016","unstructured":"Yao E-S, Tang Y, Xie M-J et al (2016) Elevated Homocysteine Level Related to Poor Outcome After Thrombolysis in Acute Ischemic Stroke. Med Sci Monit 22:3268\u20133273","journal-title":"Med Sci Monit"},{"key":"268_CR52","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1161\/STROKEAHA.116.015324","volume":"48","author":"M Zhao","year":"2017","unstructured":"Zhao M, Wang X, He M et al (2017) Homocysteine and Stroke Risk. Stroke 48:1183\u20131190. https:\/\/doi.org\/10.1161\/STROKEAHA.116.015324","journal-title":"Stroke"},{"key":"268_CR53","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.11.005","volume":"24","author":"F Zhou","year":"2015","unstructured":"Zhou F, chen B, Chen C et al (2015) Elevated Homocysteine Levels Contribute to Larger Hematoma Volume in Patients with Intracerebral Hemorrhage. J Stroke Cerebrovasc Dis 24:784\u2013788. https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2014.11.005","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"268_CR54","doi-asserted-by":"publisher","first-page":"213","DOI":"10.2174\/092986710790149774","volume":"17","author":"S Zoccolella","year":"2010","unstructured":"Zoccolella S, dell\u2019Aquila C, Specchio LM et al (2010) Elevated homocysteine levels in Parkinson\u2019s Disease: is there anything besides L-dopa treatment? Curr Med Chem 17:213\u2013221","journal-title":"Curr Med Chem"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11011-018-0268-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-018-0268-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-018-0268-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T02:30:29Z","timestamp":1604457029000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11011-018-0268-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,21]]},"references-count":54,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["268"],"URL":"https:\/\/doi.org\/10.1007\/s11011-018-0268-5","relation":{},"ISSN":["0885-7490","1573-7365"],"issn-type":[{"value":"0885-7490","type":"print"},{"value":"1573-7365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,21]]},"assertion":[{"value":"5 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All experiments were accordance with the ethical standards and were approved by the Institutional Ethics Committee of PGIMER (NK\/872\/M.Ch.\/542).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors state no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}